TK2 Gene
protein-coding GIFtS: 62
GCID: GC16M066542
|
|
thymidine kinase 2, mitochondrial
| |
Aliases
for TK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thymidine Kinase 2, Mitochondrial1 2 | | MTDPS22 5 | | MTTK2 | | Mt-TK3 | | EC 2.7.1.213 | | Mt-TK3 |
Export aliases for TK2 gene to outside databasesPrevious GC identifers: GC16M057239 GC16M066921 GC16M066280 GC16M066320 GC16M065102 GC16M066543 GC16M052417 GC16M066505 GC16M066506 |
Summaries
for TK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TK2:
This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, anddeoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis.Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternatesplicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, soare not localized to mitochondria. (provided by RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: KITM_HUMAN, O00142Function: Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Alsophosphorylates anti-viral and anti-cancer nucleoside analogs
|
Genomic Views
for TK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TK2 gene promoter:
HOXA3 Hand1 MyoD Nkx2-5 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for TK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22-q23.1 Ensembl cytogenetic band: 16q21 HGNC cytogenetic band: 16q22-q23.1TK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M066542: view genomic region
(about GC identifiers)
Start:
|
66,541,906 bp from pter |
End:
|
66,586,447 bp from pter |
Size:
|
44,542 bases |
Orientation:
|
minus strand |
|
Proteins
for TK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KITM_HUMAN, O00142 (See
protein sequence)Recommended Name: Thymidine kinase 2, mitochondrial precursor Size: 265 amino acids; 31005 Da
Subunit: Monomer
Subcellular location: Mitochondrion
Secondary accessions: B4DGJ7 B7ZAB1 E9PH08 O15238Alternative splicing: 4 isoforms: O00142-1 O00142-2 O00142-3 O00142-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TK2: NX_O00142
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00142
TK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001166114.1 NP_001166115.1 NP_001166116.1 NP_001258863.1 NP_001258864.1 NP_001258979.1 NP_004605.4
ENSEMBL proteins: ENSP00000462721 ENSP00000414334 ENSP00000433770 ENSP00000435312 ENSP00000457959 ENSP00000438143 ENSP00000455187 ENSP00000434594 ENSP00000464313 ENSP00000407469 ENSP00000463560 ENSP00000462341 ENSP00000463326 ENSP00000299697 ENSP00000440898 Reactome Protein details: O00142
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TK2 for ontologies About GeneDecksing
TK2 Antibody Products:
Assay Products for TK2: |
Protein
Domains /
Families
for TK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TK2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O00142ProtoNet protein and cluster: O00142 1 Blocks protein family: IPB002624 Deoxynucleoside kinase
UniProtKB/Swiss-Prot: KITM_HUMAN, O00142Similarity: Belongs to the DCK/DGK family |
Function
for TK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KITM_HUMAN, O00142Function: Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Alsophosphorylates anti-viral and anti-cancer nucleoside analogsCatalytic activity: ATP + thymidine = ADP + thymidine 5'-phosphate Genatlas biochemistry entry for TK2:thymidine kinase 2,pyrimidine salvage pathway,mitochondrial,involved in the activation of chemotherapeutic nucleosideanalogues
Enzyme Number (IUBMB): EC 2.7.1.211
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TK2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TK2 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): TK2 (NM_173174) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TK2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004137 | deoxycytidine kinase activity |
IEA | -- | | GO:0004797 | thymidine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016301 | kinase activity |
-- | -- | | GO:0016773 | phosphotransferase activity, alcohol group as acceptor |
IEA | -- |
TK2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TK2:
Animal Models:
Mouse knock-out Tk2tm1Anka for TK2
11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tk2):
TK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G1/S-Specific Transcription | | | 2 | Pyrimidine metabolism | | | 3 | G1/S Transition | | | 4 | Cell Cycle | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TK2
5/11 
Reactome Pathways for TK2 (see all 11)
3 
Kegg Pathways (Kegg details for TK2):
TK2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/17 Interacting proteins for TK2 (O001423 ENSP000002996974) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006139 | nucleobase-containing compound metabolic process |
TAS | 9079672 | | GO:0006206 | pyrimidine nucleobase metabolic process |
TAS | -- | | GO:0006260 | DNA replication |
-- | -- | | GO:0006264 | mitochondrial DNA replication |
IEA | -- | | GO:0009262 | deoxyribonucleotide metabolic process |
IEA | -- |
TK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TK2 for compounds About GeneDecksing
 Browse Tocris compounds for TK2
3 DrugBank Compounds for TK2 About this table
10/27 Novoseek chemical compound relationships for TK2 gene (see all 27) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| deoxycytidine |
90.8 |
43 |
15628745 (2), 1359886 (2), 9461577 (2), 9079672 (2) (see all 24) |
| deoxynucleoside |
89.4 |
4 |
12535661 (1), 15628745 (1), 17181158 (1) |
| ara-t |
88.9 |
7 |
16630572 (1), 1359886 (1), 17324575 (1), 17181158 (1) |
| deoxyguanosine |
85.7 |
21 |
11687801 (2), 12535661 (1), 15748706 (1), 12391347 (1) (see all 17) |
| thymidine |
85.1 |
135 |
10799656 (4), 19154348 (3), 17181158 (3), 11687801 (2) (see all 71) |
| fiau |
82.4 |
4 |
8726039 (3), 18459168 (1) |
| deoxyribonucleotide |
75.9 |
5 |
12391347 (1), 15921863 (1), 19815440 (1), 12873860 (1) |
| deoxyuridine |
74.7 |
6 |
11687801 (1), 2026611 (1), 10799656 (1), 11023833 (1) (see all 5) |
| pyrimidine nucleoside |
72.9 |
3 |
20391188 (1), 12213066 (1), 9461577 (1) |
| dttp |
72.2 |
17 |
19154348 (3), 1597187 (2), 18498354 (1) |
Search CenterWatch for drugs/clinical trials and news about TK2 / KITM
|
Transcripts
for TK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TK2 gene (7 alternative transcripts): NM_001172643.1 NM_001172644.1 NM_001172645.1 NM_001271934.1 NM_001271935.1 NM_001272050.1 NM_004614.4 Unigene Cluster for TK2: Thymidine kinase 2, mitochondrial Hs.512619 [show with all ESTs]Unigene Representative Sequence: NR_07352018/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000561905 ENST00000451102 ENST00000527800 ENST00000527284 ENST00000568170
ENST00000567357 ENST00000545043 ENST00000562552 ENST00000564917 ENST00000525974
ENST00000563099 ENST00000569718 ENST00000417693 ENST00000563369 ENST00000564792
ENST00000563478 ENST00000562484 ENST00000565729
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TK2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TK2 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): TK2 (NM_173174) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TK2 |
Additional cDNA sequence: AB472397.1 AF521891.1 AK026021.1 AK026041.1 AK294627.1 AK295808.1 AK302976.1 AK303590.1 AK316226.1 BC040667.1 BC113928.1 BC134344.1 BC142970.1 NR_073520.1 NR_073521.1 U77088.1 U80628.1 Y10498.3 12 DOTS entries: DT.92423746 DT.311105 DT.120724962 DT.100754974 DT.95189094 DT.40281428 DT.120725007 DT.97843928 DT.99968707 DT.100754973 DT.120724996 DT.100700090 24/177 AceView cDNA sequences (see all 177): BM994809 AW073496 CA442140 BQ718597 CA427803 BF448278 BQ000997 AI253095 AI337559 CA438732 AI459294 BP345193 AI954613 AW451763 AI333341 BQ021280 AI417654 BQ772312 AI431926 BM993629 D52159 AW268891 CR617510 BQ942713
GeneLoc Exon Structure
|
Expression
for TK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TK2
SOURCE GeneReport for Unigene cluster: Hs.512619
UniProtKB/Swiss-Prot: KITM_HUMAN, O00142Tissue specificity: Predominantly expressed in liver, pancreas, muscle, and brain
SABiosciences Custom PCR Arrays for TK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TK2 |
Orthologs
for TK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TK2 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TK21 |
thymidine kinase 2, mitochondrial |
73.42(n)
74.85(a) |
|
427551 NM_001031460.1 NP_001026631.1 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
78(a)74(a) |
1 ↔ many1 ↔ many |
GL343295.1(44433-49727) GL344789.1(10759-15428) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3982762 |
putative deoxyribonucleoside kinase |
75.15(n) |
|
AF250861.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.184012 |
Transcribed sequence with weak similarity to protein more |
77.69(n) |
|
CK028655.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dnk1 , 3 |
nucleoside diphosphate phosphorylation
deoxynucleoside more3
deoxyribonucleoside kinase1 |
44(a)3
49.53(n)1
45.75(a)1 |
|
91E23
422731 NM_079675.21 NP_524399.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G720406 |
P-loop containing nucleoside triphosphate hydrolas... |
13(a) |
1 → many |
1(27111894-27114342) |
rice
(Oryza sativa) |
Liliopsida |
---- |
deoxynucleoside kinase family, putative, expressed...deoxynucleoside kinase family, putative, expressed... |
14(a)13(a) |
many ↔ manymany ↔ many |
1(37913714-37917955) 5(21050026-21054839) |
ENSEMBL Gene Tree for TK2 (if available)
TreeFam Gene Tree for TK2 (if available) |
Paralogs
for TK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TK2 gene
- DCK2 DGUOK2
2 SIMAP similar genes for TK2 using alignment to 13 protein entries: KITM_HUMAN (see all proteins):DGUOK DCK
TK2 for paralogs About GeneDecksing
|
Genomic Variants
for TK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TK2 (66541906 - 66586447 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TK2: --
Human Gene Mutation Database (HGMD): TK2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TK2 |
|
Disorders
/ Diseases
for TK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TK2 for disorders About GeneDecksing
OMIM gene information: 188250
OMIM disorders: 609560
UniProtKB/Swiss-Prot: KITM_HUMAN, O00142
Defects in TK2 are a cause of mitochondrial DNA depletion syndrome type 2 (MTDPS2) [MIM:609560]. A disordercharacterized primarily by childhood onset of muscle weakness associated with depletion of mtDNA in skeletal muscle.There is wide clinical variability; some patients have onset in infancy and show a rapidly progressive course withearly death due to respiratory failure, whereas others have later onset of a slowly progressive myopathy
20/24  diseases for TK2 (see all 24): About MalaCardsmitochondrial dna depletion syndrome mitochondrial dna depletion syndrome 2 (myopathic type) mitochondrial dna depletion myopathy spinal muscular atrophy
muscular atrophy mitochondrial encephalomyopathy encephalomyopathy spinocerebellar ataxia
myopathy acute myeloid leukemia respiratory failure myeloid leukemia
osteosarcoma hepatitis b ataxia neurodegeneration
lung carcinoma cardiomyopathy leukemia hepatitis
1 disease from the University of Copenhagen DISEASES database for TK2:Mitochondrial encephalomyopathy 9 Novoseek disease relationships for TK2 gene About this table
Genetic Association Database (GAD): TK2
Human Genome Epidemiology (HuGE) Navigator: TK2 (7 documents)
Export disorders for TK2 gene to outside databases
|
Publications
for TK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TK2 gene, integrated from 9 sources (see all 111):
(articles sorted by number of sources associating them with TK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mitochondrial myopathy of childhood associated with mitochondrial DNA depletion and a homozygous mutation (T77M) in the TK2 gene. (PubMed id 12873860)1, 4, 9 Mancuso M....DiMauro S. (2003)
- Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes. (PubMed id 15639197)1, 2, 9 Wang L....Eriksson S. (2005)
- Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA. (PubMed id 12391347)1, 2, 9 Mancuso M.... Vu T.H. (2002)
- Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. (PubMed id 11687801)1, 2, 9 Saada A.... Elpeleg O. (2001)
- Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates. (PubMed id 9989599)1, 2, 9 Wang L.... Eriksson S. (1999)
- Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2. (PubMed id 9079672)1, 2, 9 Johansson M. and Karlsson A. (1997)
- Novel mutations in the thymidine kinase 2 gene (TK2) associated with fatal mitochondrial myopathy and mitochondrial DNA depletion. (PubMed id 15907288)1, 2, 9 Tulinius M.... Oldfors A. (2005)
- Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts. (PubMed id 19154348)1, 9 Frangini M....Bianchi V. (2009)
- Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy. (PubMed id 12493767)1, 9 Wang L....Eriksson S. (2003)
- The role of mitochondrial dNTP levels in cells with reduced TK2 activity. (PubMed id 17065084)1, 9 Desler C....Rasmussen L.J. (2006)
|
External Searches for TK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TK2 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for TK2 | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TK2 |
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About This Section
| Patent Information for TK2 gene:
Search GeneIP for patents involving TK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TK2 | | | OriGene Protein Over-expression Lysate for TK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TK2 | | OriGene 3'-UTR Clone for TK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TK2 | | OriGene Custom Protein Services for TK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TK2 |
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| | | | Search Tocris compounds for TK2 |
| |  |  |  |  | | | | | | Recombinant Protein for TK2 |
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 | | | TK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TK2 |
|  |  |  | | | | ThermoFisher Antibodies for TK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TK2 |
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