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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TK1 Gene

protein-coding   GIFtS: 67
GCID: GC17M076170

thymidine kinase 1, soluble
 Explore 41 diseases affiliated with
TK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TK1    

Aliases
for TK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thymidine Kinase 1, Soluble1 2
EC 2.7.1.213 8
TK22
Thymidine Kinase 1 Soluble Isoform2
Thymidine Kinase, Cytosolic2
Thymidine Kinase-12

External Ids:    HGNC: 118301   Entrez Gene: 70832   Ensembl: ENSG000001679007   OMIM: 1883005   UniProtKB: P041833   

Export aliases for TK1 gene to outside databases

Previous GC identifers: GC17M075994 GC17M079157 GC17M076631 GC17M076767 GC17M073681 GC17M071594


Summaries
for TK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for TK1 (Thymidine kinase 1)


Genomic Views
for TK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TK1 gene promoter:
         Sp1   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2-q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q23.2-q25.3

TK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076170:  view genomic region     (about GC identifiers)

Start:
 76,170,160 bp from pter      End:
 76,183,314 bp from pter
Size:
 13,155 bases      Orientation:
 minus strand

Proteins
for TK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KITH_HUMAN, P04183 (See protein sequence)
Recommended Name: Thymidine kinase, cytosolic  
Size: 234 amino acids; 25469 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
Miscellaneous: Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the
cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in
resting cells
4 PDB 3D structures from and Proteopedia for TK1:
1W4R (3D)        1XBT (3D)        2ORV (3D)        2WVJ (3D)    
Secondary accessions: B2RC58 Q969V0 Q9UMG9

Explore the universe of human proteins at neXtProt for TK1: NX_P04183

Post-translational modifications:

  • Phosphorylated on Ser-13 in mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04183

    • 4/8 DME Specific Peptides for TK1 (P04183) (see all 8)
     RGQIQVI  DIVEFCE  KLTAVCM  KYAKDTRY 

    TK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003249.3  
    ENSEMBL proteins: 
     ENSP00000301634   ENSP00000468425   ENSP00000468556   ENSP00000467121   ENSP00000468278  
     ENSP00000384981  
    Reactome Protein details: P04183
    Human Recombinant Protein Products: 
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    Novus Biologicals TK1 Proteins
    Novus Biologicals TK1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TK1
    Uscn Proteins for TK1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    TK1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TK1

    Protein Domains /
    Families
    for TK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TK1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001267 Thymidine_kinase
     IPR020633 Thymidine_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P04183

    ProtoNet protein and cluster: P04183

    1 Blocks protein family: IPB001267 Thymidine kinase

    UniProtKB/Swiss-Prot: KITH_HUMAN, P04183
    Similarity: Belongs to the thymidine kinase family


    Function
    for TK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KITH_HUMAN, P04183
    Catalytic activity: ATP + thymidine = ADP + thymidine 5'-phosphate

         Genatlas biochemistry entry for TK1:
    thymidine kinase 1,pyrimidine salvage pathway,soluble,putative up-regulated c-Myc target gene,

    Enzyme Number (IUBMB): EC 2.7.1.211 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TK1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TK1:
    hsa-miR-4271 hsa-miR-3185
    SwitchGear 3'UTR luciferase reporter plasmid: TK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TK1 (see all 7)
    OriGene shRNA RFP: TK1
    OriGene siRNA: TK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TK1

    Clone
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    Search LifeMap BioReagents cell lines for TK1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004797thymidine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IDA17407781
    GO:0019206nucleoside kinase activity EXP--


    TK1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TK1:
     Increased mitotic index  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Tk1tm1Vnd for TK1
         13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tk1):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  normal 
     renal/urinary system  reproductive system  respiratory system 

    TK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pyrimidine metabolism
    		Pyrimidine metabolism1.00
    		salvage pathways of pyrimidine deoxyribonucleotides0.15
    		Pyrimidine salvage reactions0.38
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Fluoropyrimidine Activity
    		Fluoropyrimidine Activity1.00
    		Fluoropyrimidine Pathway, Pharmacokinetics0.73
    4Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00
    5Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    		Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TK1
        Glucose / Energy Metabolism

    4 BioSystems Pathways for TK1 
        Fluoropyrimidine Activity
    E2F transcription factor network
    Validated targets of C-MYC transcriptional activation
    salvage pathways of pyrimidine deoxyribonucleotides

    4        Reactome Pathways for TK1
        Metabolism of nucleotides
    Metabolism
    Pyrimidine salvage reactions
    Pyrimidine metabolism

    2 PharmGKB Pathways for TK1
        Fluoropyrimidine Pathway, Pharmacokinetics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    3         Kegg Pathways  (Kegg details for TK1):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways


    TK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/199 Interacting proteins for TK1 (P041832, 3 ENSP000003016344) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044062, 3, ENSP000002292394MINT-63364 MINT-8273466 I2D: score=5 STRING: ENSP00000229239
    TP53P046372, 3, ENSP000002693054MINT-63365 MINT-8274236 I2D: score=5 STRING: ENSP00000269305
    APLP1P516932, 3MINT-63366 MINT-8272916 I2D: score=5 
    C14orf1Q9UKR52, 3MINT-8273004 MINT-63378 I2D: score=5 
    CCDC90BQ9GZT62, 3MINT-8273081 MINT-63375 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006139nucleobase-containing compound metabolic process TAS3335503
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006260DNA replication IEA--
    GO:0009165nucleotide biosynthetic process EXP--


    TK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TK1

    7 HMDB Compounds for TK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Deoxyuridine1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)951-78-0--
    Thymidine1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (see all 17)50-89-5--
    Thymidine 3',5'-cyclic monophosphate3',5'-Cyclic TMP (see all 14)6453-60-7--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    3 DrugBank Compounds for TK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Trifluridine-- 70-00-8enzymesubstrate15571283 14719131 20372850 14719072
    Dithioerythritol-- 6892-68-8target--17139284 17016423
    Thymidine-5'-Triphosphate-- --target--17139284 17016423

    10/37 Novoseek chemical compound relationships for TK1 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 91 491 17913703 (5), 8340387 (4), 7572355 (4), 15342416 (4) (see all 99)
    deoxycytidine 89.5 63 2025274 (2), 15628745 (2), 1359886 (2), 10478487 (2) (see all 34)
    aztmp 86.2 2 11708900 (1), 15247154 (1)
    dttp 85 30 17913703 (5), 17227951 (3), 16103219 (3), 17065087 (2) (see all 12)
    deoxynucleoside 84.9 7 12535661 (1), 15628745 (1), 9756765 (1)
    3'-fluoro-3'-deoxythymidine 84.7 21 15093811 (6), 18265975 (4), 14660729 (3), 11929696 (1)
    ivfru 81.8 2 15982576 (1), 9203847 (1)
    ara-t 76.7 5 16630572 (1), 1359886 (1), 18265975 (1)
    nucleoside 75.2 14 2026611 (1), 12960196 (1), 16336273 (1), 9701500 (1) (see all 10)
    o-carborane 74.3 2 15342416 (1)

    Search CenterWatch for drugs/clinical trials and news about TK1 / KITH 

    Transcripts
    for TK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TK1 gene: 
    NM_003258.4  

    Unigene Cluster for TK1:

    Thymidine kinase 1, soluble
    Hs.515122  [show with all ESTs]
    Unigene Representative Sequence: BM458046
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301634(uc002juw.2) ENST00000588734 ENST00000590862 ENST00000590430
    ENST00000586613 ENST00000592126 ENST00000405273

    miRNA
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    hsa-miR-4271 hsa-miR-3185
    SwitchGear 3'UTR luciferase reporter plasmid: TK1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB451268.1 AB451395.1 AK314950.1 BC006484.1 BC007872.2 BT006941.1 K02581.1 

    16 DOTS entries:

    DT.97855468  DT.100881281  DT.95147130  DT.100881257  DT.100678090  DT.100881262  DT.100881277  DT.100881274 
    DT.92456218  DT.100881276  DT.120920453  DT.100881264  DT.92456215  DT.95272934  DT.95272935  DT.95272939 

    24/540 AceView cDNA sequences (see all 540):

    BE744544 AW475077 BE275574 BU625692 BM558243 AI925578 CR598176 BE315181 
    CR601356 BQ689821 BU553460 BU165575 BM811592 BM553434 BI521093 AA351658 
    BM753118 BM549917 BU500421 CR611771 CR622637 BX385047 CR591037 CR620254 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                -               
    SP2:                                                
    SP3:              -                                 


    ECgene alternative splicing isoforms for TK1

    Expression
    for TK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCCTCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TK1

    SOURCE GeneReport for Unigene cluster: Hs.515122
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TK1

    Orthologs
    for TK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TK1 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tk11 , 5 thymidine kinase 11, 5 84.26(n)1
    87.55(a)1    		   11 (82.96 cM)5
    218771  NM_009387.21  NP_033413.21 
     1178155265 
    chicken
    (Gallus gallus)    		 Aves TK11 thymidine kinase 1, soluble 74.62(n)
    76.58(a)    		   395719  NM_204898.1  NP_990229.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C3VAL3_ANOCA6
    		 Thymidine kinase (EC 2.7.1.21)
    		 76(a)
    		 1 ↔ 1
    		 2(102295323-102303328)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.171792 Transcribed sequence with moderate similarity to protein more 75.62(n)    142004923 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi19b062 wufi19b06 77.84(n)   327590  BC044148.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y43C5A.53
    thk-11    		 Thymidine kinases3
    Protein THK-11    		 46(a)3
    49.32(n)1
    47.45(a)1    		   IV(10279839-10281741)3
    1779131  NM_069485.31  NP_501886.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G230701 Thymidine kinase 53.1(n)
    50.58(a)    		   832371  NM_122213.4  NP_568426.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    		 thymidine kinase, putative, expressed
    		 25(a)
    		 1 ↔ 1
    		 3(735181-738880)


    ENSEMBL Gene Tree for TK1 (if available)
    TreeFam Gene Tree for TK1 (if available) 

    Paralogs
    for TK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/332 NCBI SNPs in TK1 are shown (see all 332)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs733774091,2
    		C,--76169665(+) TTTTGT/CCCTGA 1 -- int13Minor allele frequency- C:0.05WA NA 240
    rs122324761,2
    		C,F,H,--76169771(+) CTACAG/AAAAGA 1 -- int119Minor allele frequency- A:0.19NS EA NA WA CSA 2344
    rs1487790421,2
    		--76169808(+) GCCTGC/TAATCC 1 -- int10--------
    rs20103711,2
    		C,F,A,H,--76169863(-) GGTCTT/CGAACT 1 -- int111Minor allele frequency- C:0.45NA EA EU WA CSA 448
    rs1132893191,2
    		--76169894(+) AACTCG/ATCTCT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1139498631,2
    		C,--76169895(+) ACTCGG/TCTCTA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1402823291,2
    		--76169950(+) ATATCA/GGCTAC 1 -- int10--------
    rs1439918431,2
    		--76169968(+) GCTGAC/TGGGGG 1 -- int10--------
    rs601548911,2
    		C,--76170071(+) AAAAG-/AAAAAA 1 -- int10--------
    rs1905717641,2
    		--76170234(+) CCACAC/TTTGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TK1 (76170160 - 76183314 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TK1
         1 CNV: 30027

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    Disorders / Diseases
    for TK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TK1 for disorders           About GeneDecksing

    OMIM gene information: 188300    OMIM disorders: --

    20/41 diseases for TK1 (see all 41):    About MalaCards
    dubin-johnson syndrome    non-small cell lung carcinoma    non-hodgkin lymphoma    thanatophoric dysplasia
    herpes simplex    b-cell lymphomas    hypochondroplasia    hodgkin's lymphoma
    papillary thyroid carcinoma    achondroplasia    chronic lymphocytic leukemia    epithelial ovarian cancer
    lymphocytic leukemia    hepatitis b    lung carcinoma    carcinoma
    squamous cell carcinoma    thyroid carcinoma    hepatocellular carcinoma    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for TK1:
    Hypochondroplasia

    10/24 Novoseek disease relationships for TK1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 49.7 16 15982576 (2), 16595506 (1), 11392548 (1), 17228266 (1) (see all 14)
    leukemia lymphocytic chronic 40.2 3 7967713 (1), 7660896 (1)
    tumors 37.2 67 1433372 (5), 20450760 (3), 19654105 (3), 15809747 (3) (see all 31)
    nsclc 27.7 8 16969512 (1), 15583816 (1), 20372850 (1), 15809747 (1) (see all 5)
    cancer 27 15 20372850 (3), 11289224 (2), 16391869 (1), 15375544 (1) (see all 13)
    hydatidiform mole 24.1 1 15733390 (1)
    lung carcinoma 22.6 3 16969512 (1), 20479645 (1), 20372850 (1), 17707801 (1)
    brain tumors 22.2 1 18431473 (1)
    breast cancer 16.3 13 11270425 (3), 12449723 (2), 7705935 (1), 1433372 (1) (see all 8)
    osteosarcoma 14.2 3 16630572 (1), 10226527 (1), 15982576 (1)

    Human Genome Epidemiology (HuGE) Navigator: TK1 (5 documents)

    Export disorders for TK1 gene to outside databases

    Publications
    for TK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TK1 gene, integrated from 9 sources (see all 256):
    (articles sorted by number of sources associating them with TK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Immunohistochemical characterization of pyrimidine sy nthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer. (PubMed id 20372850)1, 7, 9 Shintani M....Kamoshida S. (2010)
    2. Structures of thymidine kinase 1 of human and mycoplasmic origin. (PubMed id 15611477)1, 2, 9 Welin M....Eklund H. (2004)
    3. Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. (PubMed id 9575153)1, 2, 9 Chang Z.F.... Chi L.M. (1998)
    4. Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. (PubMed id 17407781)1, 2, 9 Segura-Pena D....Lavie A. (2007)
    5. Structure of a type II thymidine kinase with bound dTTP. (PubMed id 15733844)1, 2, 9 Birringer M.S....Scapozza L. (2005)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model. (PubMed id 14719072)1, 7 Emura T....Kitazato K. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Sequence, structure and promoter characterization of the human thymidine kinase gene. (PubMed id 3301530)1, 2 Flemington E....Deininger P.L. (1987)
    10. Genetic analysis of the human thymidine kinase gene promoter. (PubMed id 3785218)1, 2 Kreidberg J.A. and Kelly T.J. (1986)

    External Searches for TK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7083 HGNC: 11830 AceView: TK1 Ensembl:ENSG00000167900 euGenes: HUgn7083
    ECgene: TK1 Kegg: 7083 H-InvDB: TK1

    Other Databases showing TK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TK1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TK1 gene:
    Search GeneIP for patents involving TK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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