Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TK1 Gene

protein-coding   GIFtS: 70
GCID: GC17M076170

Thymidine Kinase 1, Soluble

  See TK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Thymidine Kinase 1, Soluble1 2
EC 2.7.1.213 8
TK22
Thymidine Kinase 1 Soluble Isoform2
Thymidine Kinase, Cytosolic2
Thymidine Kinase-12

External Ids:    HGNC: 118301   Entrez Gene: 70832   Ensembl: ENSG000001679007   OMIM: 1883005   UniProtKB: P041833   

Export aliases for TK1 gene to outside databases

Previous GC identifers: GC17M075994 GC17M079157 GC17M076631 GC17M076767 GC17M073681 GC17M071594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TK1 Gene:
TK1 (thymidine kinase 1, soluble) is a protein-coding gene. Diseases associated with TK1 include hypochondroplasia, and dubin-johnson syndrome. GO annotations related to this gene include thymidine kinase activity and identical protein binding.

Gene Wiki entry for TK1 (Thymidine kinase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TK1 gene promoter:
         Sp1   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTK1 promoter sequence
   Search Chromatin IP Primers for TK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2-q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q23.2-q25.3

TK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076170:  view genomic region     (about GC identifiers)

Start:
76,170,160 bp from pter      End:
76,183,314 bp from pter
Size:
13,155 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KITH_HUMAN, P04183 (See protein sequence)
Recommended Name: Thymidine kinase, cytosolic  
Size: 234 amino acids; 25469 Da
Subunit: Homotetramer
Miscellaneous: Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of
the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very
low in resting cells
4 PDB 3D structures from and Proteopedia for TK1:
1W4R (3D)        1XBT (3D)        2ORV (3D)        2WVJ (3D)    
Secondary accessions: B2RC58 Q969V0 Q9UMG9

Explore the universe of human proteins at neXtProt for TK1: NX_P04183

Explore proteomics data for TK1 at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-13 in mitosis1
  • Ubiquitination2 at Lys220
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TK1 (P04183) (see all 8)
     RGQIQVI  DIVEFCE  KLTAVCM  KYAKDTRY 


    See TK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003249.3  
    ENSEMBL proteins: 
     ENSP00000301634   ENSP00000468425   ENSP00000468556   ENSP00000467121   ENSP00000468278  
     ENSP00000384981  
    Reactome Protein details: P04183

    TK1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TK1 (Thymidine Kinase 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TK1
    OriGene Protein Over-expression Lysate for TK1
    OriGene MassSpec for TK1
    OriGene Custom Protein Services for TK1
    GenScript Custom Purified and Recombinant Proteins Services for TK1
    Novus Biologicals TK1 Proteins
    Novus Biologicals TK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TK1
    Cloud-Clone Corp. Proteins for TK1

     
    Search eBioscience for Proteins for TK1 

     
    antibodies-online proteins for TK1 (83 products) 

     
    antibodies-online peptides for TK1

    TK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TK1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TK1  (TK)
    OriGene Antibodies for TK1
    OriGene Custom Antibody Services for TK1
    Novus Biologicals TK1 Antibodies
    Abcam antibodies for TK1 (Q9QNF7, P04183)
    Cloud-Clone Corp. Antibodies for TK1
    ThermoFisher Antibody for TK1
    antibodies-online antibodies for TK1 (55 products) 

    TK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TK1
    Cloud-Clone Corp. CLIAs for TK1
    Search eBioscience for ELISAs for TK1 
    antibodies-online kits for TK1 (24 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR001267 Thymidine_kinase
     IPR027417 P-loop_NTPase
     IPR020633 Thymidine_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P04183

    ProtoNet protein and cluster: P04183

    1 Blocks protein domain: IPB001267 Thymidine kinase

    UniProtKB/Swiss-Prot: KITH_HUMAN, P04183
    Similarity: Belongs to the thymidine kinase family


    Find genes that share domains with TK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KITH_HUMAN, P04183
    Catalytic activity: ATP + thymidine = ADP + thymidine 5'-phosphate

         Genatlas biochemistry entry for TK1:
    thymidine kinase 1,pyrimidine salvage pathway,soluble,putative up-regulated c-Myc target gene,

         Enzyme Number (IUBMB): EC 2.7.1.211 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004797thymidine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IDA17407781
    GO:0019206nucleoside kinase activity EXP--
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with TK1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TK1:
     Increased mitotic index  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tk1):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  normal 
     renal/urinary system  reproductive system  respiratory system 

    Find genes that share phenotypes with TK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tk1tm1Vnd for TK1

       genOway: Develop your customized and physiologically relevant rodent model for TK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TK1:
    hsa-mir-103a-3p (MIRT048356), hsa-mir-186-3p (MIRT038616), hsa-mir-26b-5p (MIRT029423), hsa-mir-193b-3p (MIRT016357)

    Block miRNA regulation of human, mouse, rat TK1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TK1:
    hsa-miR-4271 hsa-miR-3185
    SwitchGear 3'UTR luciferase reporter plasmidTK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TK1
    Predesigned siRNA for gene silencing in human, mouse, rat TK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TK1

    Clone
    Products:
         
    OriGene clones in human, mouse for TK1 (see all 6)
    OriGene ORF clones in mouse, rat for TK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TK1 (NM_005990)
    Sino Biological Human cDNA Clone for TK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TK1
    Addgene plasmids for TK1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KITH_HUMAN, P04183: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TK1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Pyrimidine metabolism0.33
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    Pyrimidine salvage reactions0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    pyrimidine deoxyribonucleosides salvage0.00
    4Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    5Purine metabolism (KEGG)
    Pyrimidine metabolism0.38


    Find genes that share SuperPaths with TK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TK1
        Glucose / Energy Metabolism

    5 BioSystems Pathways for TK1
        Fluoropyrimidine Activity
    E2F transcription factor network
    Validated targets of C-MYC transcriptional activation
    pyrimidine deoxyribonucleosides salvage
    superpathway of pyrimidine deoxyribonucleoside salvage


    1 Reactome Pathway for TK1
        Pyrimidine salvage reactions

    2 PharmGKB Pathways for TK1
        Fluoropyrimidine Pathway, Pharmacokinetics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for TK1):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TK1
    Interactions:

        GeneGlobe Interaction Network for TK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TK1 (P041831, 2, 3 ENSP000003016344) via UniProtKB, MINT, STRING, and/or I2D (see all 216)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDAH2O958652, 3MINT-8273257 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8273257 I2D: score=2 
    ENSG00000225635O958652, 3MINT-8273257 I2D: score=2 
    ENSG00000226634O958652, 3MINT-8273257 I2D: score=2 
    ENSG00000227317O958652, 3MINT-8273257 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006139nucleobase-containing compound metabolic process TAS3335503
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006260DNA replication IEA--
    GO:0009157deoxyribonucleoside monophosphate biosynthetic process TAS3335503

    Find genes that share ontologies with TK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TK1 (KITH)

    7 HMDB Compounds for TK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Deoxyuridine1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)951-78-0--
    Thymidine1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (see all 17)50-89-5--
    Thymidine 3',5'-cyclic monophosphate3',5'-Cyclic TMP (see all 14)6453-60-7--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    4 DrugBank Compounds for TK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Trifluridine-- 70-00-8enzymesubstrate15571283 14719131 20372850 14719072
    Dithioerythritol-- 6892-68-8target--17139284 17016423
    Thymidine-5'-Triphosphate-- --target--17139284 17016423
    ZidovudineAzidothymidine (see all 3)30516-87-1enzymesubstrate2430286

    Selected Novoseek inferred chemical compound relationships for TK1 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 91 491 17913703 (5), 8340387 (4), 7572355 (4), 15342416 (4) (see all 99)
    deoxycytidine 89.5 63 2025274 (2), 15628745 (2), 1359886 (2), 10478487 (2) (see all 34)
    aztmp 86.2 2 11708900 (1), 15247154 (1)
    dttp 85 30 17913703 (5), 17227951 (3), 16103219 (3), 17065087 (2) (see all 12)
    deoxynucleoside 84.9 7 12535661 (1), 15628745 (1), 9756765 (1)
    3'-fluoro-3'-deoxythymidine 84.7 21 15093811 (6), 18265975 (4), 14660729 (3), 11929696 (1)
    ivfru 81.8 2 15982576 (1), 9203847 (1)
    ara-t 76.7 5 16630572 (1), 1359886 (1), 18265975 (1)
    nucleoside 75.2 14 2026611 (1), 12960196 (1), 16336273 (1), 9701500 (1) (see all 10)
    o-carborane 74.3 2 15342416 (1)



    Find genes that share compounds with TK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TK1 gene: 
    NM_003258.4  

    Unigene Cluster for TK1:

    Thymidine kinase 1, soluble
    Hs.515122  [show with all ESTs]
    Unigene Representative Sequence: BM458046
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301634(uc002juw.2) ENST00000588734 ENST00000590862 ENST00000590430
    ENST00000586613 ENST00000592126 ENST00000405273
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TK1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TK1:
    hsa-miR-4271 hsa-miR-3185
    SwitchGear 3'UTR luciferase reporter plasmidTK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TK1
    Predesigned siRNA for gene silencing in human, mouse, rat TK1
    Clone
    Products:
         
    OriGene clones in human, mouse for TK1 (see all 6)
    OriGene ORF clones in mouse, rat for TK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TK1 (NM_005990)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TK1
    Addgene plasmids for TK1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TK1
    OriGene qSTAR qPCR primer pairs in human, mouse for TK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TK1
      QuantiTect SYBR Green Assays in human, mouse, rat TK1
      QuantiFast Probe-based Assays in human, mouse, rat TK1

    Additional mRNA sequence: 

    AB451268.1 AB451395.1 AK314950.1 BC006484.1 BC007872.2 BT006941.1 K02581.1 

    16 DOTS entries:

    DT.97855468  DT.100881281  DT.95147130  DT.100881257  DT.100678090  DT.100881262  DT.100881277  DT.100881274 
    DT.92456218  DT.100881276  DT.120920453  DT.100881264  DT.92456215  DT.95272934  DT.95272935  DT.95272939 

    Selected AceView cDNA sequences (see all 540):

    BM756246 BM463332 BE275574 AW475077 BE396358 BE315181 CR596456 BG387955 
    BE792985 CR622637 CR624049 BE513902 BG677928 BU186396 AA878071 CR615052 
    BU183377 CR599432 BQ691579 CR590511 AA351658 CR607869 BM552819 BM751768 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                -               
    SP2:                                                
    SP3:              -                                 


    ECgene alternative splicing isoforms for TK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCTCCTC
    TK1 Expression
    About this image


    TK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
    TK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515122
        Custom PCR Arrays for TK1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TK1
    OriGene qSTAR qPCR primer pairs in human, mouse for TK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TK1
    QuantiTect SYBR Green Assays in human, mouse, rat TK1
    QuantiFast Probe-based Assays in human, mouse, rat TK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TK1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tk11 , 5 thymidine kinase 11, 5 84.26(n)1
    87.55(a)1
      11 (82.96 cM)5
    218771  NM_009387.21  NP_033413.21 
     1178155265 
    chicken
    (Gallus gallus)
    Aves TK11 thymidine kinase 1, soluble 74.62(n)
    76.58(a)
      395719  NM_204898.1  NP_990229.1 
    lizard
    (Anolis carolinensis)
    Reptilia TK16
    thymidine kinase 1, soluble
    76(a)
    1 ↔ 1
    2(102294901-102303328)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171792 Transcribed sequence with moderate similarity to protein more 75.62(n)    142004923 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi19b062 wufi19b06 77.84(n)   327590  BC044148.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y43C5A.53
    thk-11
    Thymidine kinases3
    thk-11
    46(a)3
    48.99(n)1
    46.97(a)1
      IV(10279839-10281741)3
    1779131  NM_001268548.11  NP_001255477.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G230701 AT5G23070 53.1(n)
    50.58(a)
      832371  NM_122213.4  NP_568426.1 


    ENSEMBL Gene Tree for TK1 (if available)
    TreeFam Gene Tree for TK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TK1 (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733774091,2
    C,F--76169665(+) TTTTGT/CCCTGA 1 -- int13Minor allele frequency- C:0.05WA NA 240
    rs122324761,2
    C,F,H--76169771(+) CTACAG/AAAAGA 1 -- int119Minor allele frequency- A:0.19NS EA NA WA CSA 2344
    rs1487790421,2
    --76169808(+) GCCTGC/TAATCC 1 -- int10--------
    rs20103711,2
    C,F,A,H--76169863(-) GGTCTT/CGAACT 1 -- int111Minor allele frequency- C:0.45NA EA EU WA CSA 448
    rs1132893191,2
    C,F--76169894(+) AACTCG/ATCTCT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1139498631,2
    C,F--76169895(+) ACTCGG/TCTCTA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1402823291,2
    --76169950(+) ATATCA/GGCTAC 1 -- int10--------
    rs1439918431,2
    --76169968(+) GCTGAC/TGGGGG 1 -- int10--------
    rs601548911,2
    C--76170071(+) AAAAG-/AAAAAA 1 -- int10--------
    rs1905717641,2
    --76170234(+) CCACAC/TTTGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TK1 (76170160 - 76183314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3277n71CNV Loss21882294
    nsv908860CNV Loss21882294
    nsv470607CNV Loss18288195
    dgv3279n71CNV Loss21882294
    dgv3278n71CNV Loss21882294
    nsv524306CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TK1
    DNA2.0 Custom Variant and Variant Library Synthesis for TK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 188300    OMIM disorders: --

    4 diseases for TK1:    
    About MalaCards
    hypochondroplasia    dubin-johnson syndrome    thanatophoric dysplasia    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for TK1:
    Hypochondroplasia

    Find genes that share disorders with TK1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TK1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 49.7 16 15982576 (2), 16595506 (1), 11392548 (1), 17228266 (1) (see all 14)
    leukemia lymphocytic chronic 40.2 3 7967713 (1), 7660896 (1)
    tumors 37.2 67 1433372 (5), 20450760 (3), 19654105 (3), 15809747 (3) (see all 31)
    nsclc 27.7 8 16969512 (1), 15583816 (1), 20372850 (1), 15809747 (1) (see all 5)
    cancer 27 15 20372850 (3), 11289224 (2), 16391869 (1), 15375544 (1) (see all 13)
    hydatidiform mole 24.1 1 15733390 (1)
    lung carcinoma 22.6 3 16969512 (1), 20479645 (1), 20372850 (1), 17707801 (1)
    brain tumors 22.2 1 18431473 (1)
    breast cancer 16.3 13 11270425 (3), 12449723 (2), 7705935 (1), 1433372 (1) (see all 8)
    osteosarcoma 14.2 3 16630572 (1), 10226527 (1), 15982576 (1)

    Genetic Association Database (GAD): TK1
    Human Genome Epidemiology (HuGE) Navigator: TK1 (5 documents)

    Export disorders for TK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TK1 gene, integrated from 10 sources (see all 269):
    (articles sorted by number of sources associating them with TK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer. (PubMed id 20372850)1, 7, 9 Shintani M....Kamoshida S. (Oncol. Rep. 2010)
    2. Structures of thymidine kinase 1 of human and mycoplasmic origin. (PubMed id 15611477)1, 2, 9 Welin M.... Eklund H. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. (PubMed id 9575153)1, 2, 9 Chang Z.F.... Chi L.M. (J. Biol. Chem. 1998)
    4. Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. (PubMed id 17407781)1, 2, 9 Segura-Pena D.... Lavie A. (J. Mol. Biol. 2007)
    5. Structure of a type II thymidine kinase with bound dTTP. (PubMed id 15733844)1, 2, 9 Birringer M.S....Scapozza L. (FEBS Lett. 2005)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model. (PubMed id 14719072)1, 7 Emura T....Kitazato K. (Oncol. Rep. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Sequence, structure and promoter characterization of the human thymidine kinase gene. (PubMed id 3301530)1, 2 Flemington E....Deininger P.L. (Gene 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7083 HGNC: 11830 AceView: TK1 Ensembl:ENSG00000167900 euGenes: HUgn7083
    ECgene: TK1 Kegg: 7083 H-InvDB: TK1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TK1 gene:
    Search GeneIP for patents involving TK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TK1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TK1 (Thymidine Kinase 1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TK1   OriGene RNAi products in human, mouse, rat for TK1  
     OriGene qPCR primer pairs and template standards for TK1   OriGene Protein Over-expression Lysate for TK1  
     OriGene MassSpec for TK1   OriGene clones in human, mouse for TK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TK1   OriGene Purified Protein for TK1  
     OriGene ORF clones in mouse, rat for TK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TK1   OriGene Custom Protein Services for TK1  

     
     
     Block miRNA regulation of human, mouse, rat TK1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TK1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TK1 Predesigned siRNA for gene silencing in human, mouse, rat TK1
     QuantiFast Probe-based Assays in human, mouse, rat TK1 QuantiTect SYBR Green Assays in human, mouse, rat TK1
     Custom PCR Arrays for TK1 Search Chromatin IP Primers for TK1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TK1  GeneGlobe Interaction Network for TK1
     Regulatory tfbs in TK1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TK1 GenScript cDNA clones with any tag delivered in your preferred vector for TK1
     GenScript Custom Assay Services for TK1 GenScript Custom overexpressing Cell Line Services for TK1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TK1  (TK)

     Search Tocris compounds for TK1 (KITH)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TK1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TK1 antibodies
     TK1 proteins
     TK1 lysates
     Antibodies for TK1
     See all of Abcam's Antibodies, Kits and Proteins for TK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TK1
     Proteins for TK1
     Antibodies for TK1
     ELISAs for TK1
     CLIAs for TK1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TK1
     SwitchGear 3'UTR luciferase reporter plasmids for TK1
     SwitchGear Promoter luciferase reporter plasmids for TK1
     ThermoFisher Antibody for TK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TK1
     Browse compounds at ApexBio
     Addgene plasmids for TK1
      Search eBioscience for proteins for TK1
      Search eBioscience for elisas for TK1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TK1
     antibodies-online antibodies for TK1 (55 products)
     antibodies-online kits for TK1 (24 products)
     antibodies-online peptides for TK1
     antibodies-online proteins for TK1 (83 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TK1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4