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Aliases for TK1 Gene

Aliases for TK1 Gene

  • Thymidine Kinase 1, Soluble 2 3
  • EC 2.7.1.21 4 64
  • Thymidine Kinase 1 Soluble Isoform 3
  • Thymidine Kinase, Cytosolic 3
  • Thymidine Kinase-1 3
  • TK2 3

External Ids for TK1 Gene

Summaries for TK1 Gene

GeneCards Summary for TK1 Gene

TK1 (Thymidine Kinase 1, Soluble) is a Protein Coding gene. Diseases associated with TK1 include colorectal cancer and thanatophoric dysplasia, type i. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding and thymidine kinase activity.

Gene Wiki entry for TK1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TK1 Gene

Genomics for TK1 Gene

Genomic Location for TK1 Gene

Start:
78,174,075 bp from pter
End:
78,187,233 bp from pter
Size:
13,159 bases
Orientation:
Minus strand

Genomic View for TK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TK1 Gene

Regulatory Elements for TK1 Gene

Transcription factor binding sites by QIAGEN in the TK1 gene promoter:

Proteins for TK1 Gene

  • Protein details for TK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04183-KITH_HUMAN
    Recommended name:
    Thymidine kinase, cytosolic
    Protein Accession:
    P04183
    Secondary Accessions:
    • B2RC58
    • Q969V0
    • Q9UMG9

    Protein attributes for TK1 Gene

    Size:
    234 amino acids
    Molecular mass:
    25469 Da
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells

    Three dimensional structures from OCA and Proteopedia for TK1 Gene

neXtProt entry for TK1 Gene

Proteomics data for TK1 Gene at MOPED

Selected DME Specific Peptides for TK1 Gene

Post-translational modifications for TK1 Gene

Other Protein References for TK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TK1 Gene

Protein Domains for TK1 Gene

UniProtKB/Swiss-Prot:

KITH_HUMAN
Family:
  • Belongs to the thymidine kinase family.:
    • P04183
genes like me logo Genes that share domains with TK1: view

No data available for Gene Families for TK1 Gene

Function for TK1 Gene

Molecular function for TK1 Gene

GENATLAS Biochemistry: thymidine kinase 1,pyrimidine salvage pathway,soluble,putative up-regulated c-Myc target gene,
UniProtKB/Swiss-Prot CatalyticActivity: ATP + thymidine = ADP + thymidine 5-phosphate

Enzyme Numbers (IUBMB) for TK1 Gene

Gene Ontology (GO) - Molecular Function for TK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004797 thymidine kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0008270 zinc ion binding IDA 17407781
GO:0019206 nucleoside kinase activity EXP --
genes like me logo Genes that share ontologies with TK1: view
genes like me logo Genes that share phenotypes with TK1: view

Animal Models for TK1 Gene

MGI Knock Outs for TK1:

miRNA for TK1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for TK1 Gene

Localization for TK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TK1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TK1 Gene COMPARTMENTS Subcellular localization image for TK1 gene
Compartment Confidence
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TK1: view

Pathways for TK1 Gene

genes like me logo Genes that share pathways with TK1: view

Gene Ontology (GO) - Biological Process for TK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 3335503
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process TAS 3335503
GO:0009165 nucleotide biosynthetic process EXP --
genes like me logo Genes that share ontologies with TK1: view

Compounds for TK1 Gene

(7) HMDB Compounds for TK1 Gene

Compound Synonyms Cas Number PubMed IDs
5-Thymidylic acid
  • 2'-Deoxythymidine 5'-monophosphate
365-07-1
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Deoxyuridine
  • 1-(2-Deoxy-D-erythro-pentofuranosyl)uracil
951-78-0
dUMP
  • 2'-Deoxy-5'-uridylate
964-26-1

(4) Drugbank Compounds for TK1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dithioerythritol
6892-68-8 target
Thymidine-5'-Triphosphate
target
Trifluridine
70-00-8 enzyme substrate
Zidovudine
  • Azidothymidine
30516-87-1 enzyme substrate

(37) Novoseek inferred chemical compound relationships for TK1 Gene

Compound -log(P) Hits PubMed IDs
thymidine 91 182
deoxycytidine 89.5 41
aztmp 86.2 2
dttp 85 22
deoxynucleoside 84.9 3
genes like me logo Genes that share compounds with TK1: view

Transcripts for TK1 Gene

Unigene Clusters for TK1 Gene

Thymidine kinase 1, soluble:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2:
SP3: -

Relevant External Links for TK1 Gene

GeneLoc Exon Structure for
TK1
ECgene alternative splicing isoforms for
TK1

Expression for TK1 Gene

mRNA expression in normal human tissues for TK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TK1 Gene

SOURCE GeneReport for Unigene cluster for TK1 Gene Hs.515122

genes like me logo Genes that share expressions with TK1: view

Orthologs for TK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TK1 36
  • 99.15 (n)
  • 100 (a)
TK1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TK1 36
  • 87.04 (n)
  • 89.32 (a)
TK1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TK1 36
  • 87.75 (n)
  • 91.88 (a)
TK1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tk1 36
  • 84.26 (n)
  • 87.55 (a)
Tk1 16
Tk1 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TK1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tk1 36
  • 83.91 (n)
  • 88.36 (a)
chicken
(Gallus gallus)
Aves TK1 36
  • 74.62 (n)
  • 76.58 (a)
TK1 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TK1 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17179 36
tk1 36
  • 71.64 (n)
  • 79.1 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9394 36
zebrafish
(Danio rerio)
Actinopterygii LOC100537847 36
  • 67.11 (n)
  • 69.6 (a)
tk1 37
  • 68 (a)
OneToOne
wufi19b06 36
worm
(Caenorhabditis elegans)
Secernentea thk-1 36
  • 48.99 (n)
  • 46.97 (a)
thk-1 37
  • 36 (a)
OneToOne
Y43C5A.5 38
  • 46 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23070 36
  • 53.1 (n)
  • 50.58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1817 36
Species with no ortholog for TK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TK1 Gene

ENSEMBL:
Gene Tree for TK1 (if available)
TreeFam:
Gene Tree for TK1 (if available)

Paralogs for TK1 Gene

No data available for Paralogs for TK1 Gene

Variants for TK1 Gene

Sequence variations from dbSNP and Humsavar for TK1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs735170 -- 78,178,398(-) ACCCC(A/G)GGCAA intron-variant
rs762541 -- 78,179,007(-) AGCCT(A/G)TAGGA intron-variant
rs762542 -- 78,178,518(-) GAAGC(C/T)CAGCC intron-variant
rs762543 -- 78,178,394(-) CGGGC(A/G)AGACA intron-variant
rs1052931 -- 78,174,666(-) GTCGG(A/G)AGGCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TK1 Gene

Variant ID Type Subtype PubMed ID
nsv908860 CNV Loss 21882294
dgv3277n71 CNV Loss 21882294
dgv3278n71 CNV Loss 21882294
nsv470607 CNV Loss 18288195
dgv3279n71 CNV Loss 21882294
nsv524306 CNV Gain 19592680

Relevant External Links for TK1 Gene

HapMap Linkage Disequilibrium report
TK1

Disorders for TK1 Gene

(1) University of Copenhagen DISEASES for TK1 Gene

(24) Novoseek inferred disease relationships for TK1 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 49.7 15
leukemia lymphocytic chronic 40.2 2
tumors 37.2 45
nsclc 27.7 5
cancer 27 16

Relevant External Links for TK1

Genetic Association Database (GAD)
TK1
Human Genome Epidemiology (HuGE) Navigator
TK1
genes like me logo Genes that share disorders with TK1: view

No data available for UniProtKB/Swiss-Prot for TK1 Gene

Publications for TK1 Gene

  1. Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. (PMID: 9575153) Chang Z.F. … Chi L.M. (J. Biol. Chem. 1998) 3 4 23
  2. Structures of thymidine kinase 1 of human and mycoplasmic origin. (PMID: 15611477) Welin M. … Eklund H. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  3. Structure of a type II thymidine kinase with bound dTTP. (PMID: 15733844) Birringer M.S. … Scapozza L. (FEBS Lett. 2005) 3 4 23
  4. Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. (PMID: 17407781) Segura-Pena D. … Lavie A. (J. Mol. Biol. 2007) 3 4 23
  5. Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer. (PMID: 20372850) Shintani M. … Kamoshida S. (Oncol. Rep. 2010) 3 23 25

Products for TK1 Gene

  • Addgene plasmids for TK1

Sources for TK1 Gene

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