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Aliases for TJP3 Gene

Aliases for TJP3 Gene

  • Tight Junction Protein 3 2 3 4
  • ZO3 3 4 6
  • Zonula Occludens Protein 3 3 4
  • Zona Occludens Protein 3 3 4
  • Tight Junction Protein 3 (Zona Occludens 3) 3
  • Tight Junction Protein ZO-3 3
  • Zona Occludens 3 2
  • ZO-3 3

External Ids for TJP3 Gene

Previous GeneCards Identifiers for TJP3 Gene

  • GC19P003820
  • GC19P003648
  • GC19P003679
  • GC19P003659
  • GC19P003493

Summaries for TJP3 Gene

Entrez Gene Summary for TJP3 Gene

  • The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]

GeneCards Summary for TJP3 Gene

TJP3 (Tight Junction Protein 3) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Adhesion. An important paralog of this gene is TJP2.

Gene Wiki entry for TJP3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TJP3 Gene

Genomics for TJP3 Gene

Genomic Location for TJP3 Gene

3,708,109 bp from pter
3,750,813 bp from pter
42,705 bases
Plus strand

Genomic View for TJP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TJP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TJP3 Gene

Proteins for TJP3 Gene

  • Protein details for TJP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tight junction protein ZO-3
    Protein Accession:
    Secondary Accessions:
    • A6NFP3
    • B3KR73
    • B3KXZ0
    • B4E2W6
    • F5H2X0
    • F5H4S9
    • K7EK22
    • Q32N01

    Protein attributes for TJP3 Gene

    919 amino acids
    Molecular mass:
    101397 Da
    Quaternary structure:
    • Interacts with occludin, claudins and ZO-1. Interacts with INADL (By similarity). Interacts with UBN1. Interacts with FASLG.
    • Sequence=AAC72274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW69293.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TJP3 Gene

    Alternative splice isoforms for TJP3 Gene


neXtProt entry for TJP3 Gene

Proteomics data for TJP3 Gene at MOPED

Post-translational modifications for TJP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TJP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TJP3 (ZO3)

No data available for DME Specific Peptides for TJP3 Gene

Domains for TJP3 Gene

Suggested Antigen Peptide Sequences for TJP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95049
  • Contains 1 guanylate kinase-like domain.
  • Contains 3 PDZ (DHR) domains.
  • Contains 1 SH3 domain.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with TJP3: view

No data available for Gene Families for TJP3 Gene

Function for TJP3 Gene

Molecular function for TJP3 Gene

GENATLAS Biochemistry:
tight junction (zona occludens 3) protein ZO-3

Gene Ontology (GO) - Molecular Function for TJP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18823282
genes like me logo Genes that share ontologies with TJP3: view

Phenotypes for TJP3 Gene

genes like me logo Genes that share phenotypes with TJP3: view

Animal Model Products

miRNA for TJP3 Gene

miRTarBase miRNAs that target TJP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TJP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TJP3 Gene

Localization for TJP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TJP3 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction.

Subcellular locations from

Jensen Localization Image for TJP3 Gene COMPARTMENTS Subcellular localization image for TJP3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TJP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18823282
GO:0005654 nucleoplasm IDA --
GO:0005923 bicellular tight junction IDA 18823282
GO:0016324 apical plasma membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with TJP3: view

Pathways for TJP3 Gene

genes like me logo Genes that share pathways with TJP3: view

Pathways by source for TJP3 Gene

2 Cell Signaling Technology pathways for TJP3 Gene
1 KEGG pathway for TJP3 Gene
2 GeneGo (Thomson Reuters) pathways for TJP3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TJP3 Gene

Gene Ontology (GO) - Biological Process for TJP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000045 regulation of G1/S transition of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with TJP3: view

Compounds for TJP3 Gene

(2) Novoseek inferred chemical compound relationships for TJP3 Gene

Compound -log(P) Hits PubMed IDs
guanylate 39.3 2
calcium 16.9 1
genes like me logo Genes that share compounds with TJP3: view

Transcripts for TJP3 Gene

Unigene Clusters for TJP3 Gene

Tight junction protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TJP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TJP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
SP1: - - -
SP2: - - -
SP3: - - - - -
SP5: - -
SP6: - - -

ExUns: 20b ^ 21 ^ 22

Relevant External Links for TJP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TJP3 Gene

mRNA expression in normal human tissues for TJP3 Gene

mRNA differential expression in normal tissues according to GTEx for TJP3 Gene

This gene is overexpressed in Colon - Transverse (11.3), Esophagus - Mucosa (5.7), Small Intestine - Terminal Ileum (5.0), and Stomach (4.5).

Protein differential expression in normal tissues for TJP3 Gene

This gene is overexpressed in Salivary gland (18.3), Urine (9.2), Rectum (8.9), Lung (7.5), and Pancreas (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TJP3 Gene

SOURCE GeneReport for Unigene cluster for TJP3 Gene Hs.25527

genes like me logo Genes that share expressions with TJP3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for TJP3 Gene

Orthologs for TJP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TJP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TJP3 35
  • 84.41 (n)
  • 84.99 (a)
ZO3 36
  • 85 (a)
(Canis familiaris)
Mammalia TJP3 35
  • 84.39 (n)
  • 85.59 (a)
TJP3 36
  • 75 (a)
(Mus musculus)
Mammalia Tjp3 35
  • 80.02 (n)
  • 82.89 (a)
Tjp3 36
  • 82 (a)
(Pan troglodytes)
Mammalia TJP3 35
  • 98.71 (n)
  • 99.35 (a)
TJP3 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Tjp3 35
  • 79.87 (n)
  • 83.09 (a)
(Monodelphis domestica)
Mammalia TJP3 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves TJP3 35
  • 67.11 (n)
  • 63.42 (a)
TJP3 36
  • 50 (a)
(Anolis carolinensis)
Reptilia TJP3 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11430 35
tjp3 35
  • 60.34 (n)
  • 61.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52795 35
(Danio rerio)
Actinopterygii Dr.21038 35
tjp3 36
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12768 35
fruit fly
(Drosophila melanogaster)
Insecta pyd 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea zoo-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for TJP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TJP3 Gene

Gene Tree for TJP3 (if available)
Gene Tree for TJP3 (if available)

Paralogs for TJP3 Gene

Paralogs for TJP3 Gene

Selected SIMAP similar genes for TJP3 Gene using alignment to 4 proteins: Pseudogenes for TJP3 Gene

genes like me logo Genes that share paralogs with TJP3: view

Variants for TJP3 Gene

Sequence variations from dbSNP and Humsavar for TJP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs473583 -- 3,722,756(+) GACTT(C/T)TTCCT intron-variant
rs475112 -- 3,745,548(+) TGCAC(A/G)ATCCA intron-variant
rs478723 -- 3,745,943(+) GGGCA(C/G)GTAGG intron-variant
rs487980 -- 3,737,243(+) TATCA(A/G)TGTCA intron-variant
rs489843 -- 3,709,916(+) AGGTC(A/G)AGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TJP3 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3656n71 CNV Loss 21882294
dgv3660n71 CNV Loss 21882294
dgv3662n71 CNV Loss 21882294
nsv509718 CNV Insertion 20534489
nsv910768 CNV Loss 21882294
nsv910770 CNV Loss 21882294
dgv3663n71 CNV Loss 21882294
nsv910773 CNV Loss 21882294
nsv513509 CNV Insertion 21212237
nsv910775 CNV Loss 21882294

Relevant External Links for TJP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TJP3 Gene

Disorders for TJP3 Gene

Relevant External Links for TJP3

Genetic Association Database (GAD)

No disorders were found for TJP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TJP3 Gene

Publications for TJP3 Gene

  1. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). (PMID: 18823282) Aho S. … Gruffat H. (Biol. Cell 2009) 3 4
  2. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TJP3 Gene

Sources for TJP3 Gene

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