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Aliases for TJP3 Gene

Aliases for TJP3 Gene

  • Tight Junction Protein 3 2 3 4 5
  • Zonula Occludens Protein 3 3 4
  • Zona Occludens Protein 3 3 4
  • ZO3 3 4
  • Tight Junction Protein 3 (Zona Occludens 3) 3
  • Zona Occludens 3 2
  • ZO-3 3

External Ids for TJP3 Gene

Previous GeneCards Identifiers for TJP3 Gene

  • GC19P003820
  • GC19P003648
  • GC19P003679
  • GC19P003659
  • GC19P003493

Summaries for TJP3 Gene

Entrez Gene Summary for TJP3 Gene

  • The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]

GeneCards Summary for TJP3 Gene

TJP3 (Tight Junction Protein 3) is a Protein Coding gene. Among its related pathways are Tight junction and Adhesion. An important paralog of this gene is TJP2.

Gene Wiki entry for TJP3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TJP3 Gene

Genomics for TJP3 Gene

Regulatory Elements for TJP3 Gene

Enhancers for TJP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TJP3 on UCSC Golden Path with GeneCards custom track

Promoters for TJP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TJP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TJP3 Gene

3,708,109 bp from pter
3,750,813 bp from pter
42,705 bases
Plus strand

Genomic View for TJP3 Gene

Genes around TJP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TJP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TJP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TJP3 Gene

Proteins for TJP3 Gene

  • Protein details for TJP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tight junction protein ZO-3
    Protein Accession:
    Secondary Accessions:
    • A6NFP3
    • B3KR73
    • B3KXZ0
    • B4E2W6
    • F5H2X0
    • F5H4S9
    • K7EK22
    • Q32N01

    Protein attributes for TJP3 Gene

    919 amino acids
    Molecular mass:
    101397 Da
    Quaternary structure:
    • Interacts with occludin, claudins and ZO-1. Interacts with INADL (By similarity). Interacts with UBN1. Interacts with FASLG.
    • Sequence=AAC72274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW69293.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TJP3 Gene

    Alternative splice isoforms for TJP3 Gene


neXtProt entry for TJP3 Gene

Proteomics data for TJP3 Gene at MOPED

Post-translational modifications for TJP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TJP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TJP3 (ZO3)

No data available for DME Specific Peptides for TJP3 Gene

Domains & Families for TJP3 Gene

Suggested Antigen Peptide Sequences for TJP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 guanylate kinase-like domain.
  • Belongs to the MAGUK family.
  • Contains 1 guanylate kinase-like domain.
  • Contains 3 PDZ (DHR) domains.
  • Contains 1 SH3 domain.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with TJP3: view

Function for TJP3 Gene

Molecular function for TJP3 Gene

GENATLAS Biochemistry:
tight junction (zona occludens 3) protein ZO-3
genes like me logo Genes that share phenotypes with TJP3: view

Animal Models for TJP3 Gene

MGI Knock Outs for TJP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TJP3 Gene

Localization for TJP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TJP3 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction.

Subcellular locations from

Jensen Localization Image for TJP3 Gene COMPARTMENTS Subcellular localization image for TJP3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TJP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005923 bicellular tight junction IDA 18823282
genes like me logo Genes that share ontologies with TJP3: view

Pathways & Interactions for TJP3 Gene

genes like me logo Genes that share pathways with TJP3: view

Pathways by source for TJP3 Gene

2 Cell Signaling Technology pathways for TJP3 Gene
1 KEGG pathway for TJP3 Gene
2 GeneGo (Thomson Reuters) pathways for TJP3 Gene

Interacting Proteins for TJP3 Gene

Gene Ontology (GO) - Biological Process for TJP3 Gene


No data available for SIGNOR curated interactions for TJP3 Gene

Drugs & Compounds for TJP3 Gene

(1) Drugs for TJP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TJP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TJP3: view

Transcripts for TJP3 Gene

Unigene Clusters for TJP3 Gene

Tight junction protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TJP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
SP1: - - -
SP2: - - -
SP3: - - - - -
SP5: - -
SP6: - - -

ExUns: 20b ^ 21 ^ 22

Relevant External Links for TJP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TJP3 Gene

mRNA expression in normal human tissues for TJP3 Gene

mRNA differential expression in normal tissues according to GTEx for TJP3 Gene

This gene is overexpressed in Colon - Transverse (x11.3), Esophagus - Mucosa (x5.7), Small Intestine - Terminal Ileum (x5.0), and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for TJP3 Gene

This gene is overexpressed in Salivary gland (18.3), Urine (9.2), Rectum (8.9), Lung (7.5), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TJP3 Gene

SOURCE GeneReport for Unigene cluster for TJP3 Gene Hs.25527

genes like me logo Genes that share expression patterns with TJP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TJP3 Gene

Orthologs for TJP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TJP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TJP3 35
  • 84.41 (n)
  • 84.99 (a)
ZO3 36
  • 85 (a)
(Canis familiaris)
Mammalia TJP3 35
  • 84.39 (n)
  • 85.59 (a)
TJP3 36
  • 75 (a)
(Mus musculus)
Mammalia Tjp3 35
  • 80.02 (n)
  • 82.89 (a)
Tjp3 16
Tjp3 36
  • 82 (a)
(Pan troglodytes)
Mammalia TJP3 35
  • 98.71 (n)
  • 99.35 (a)
TJP3 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Tjp3 35
  • 79.87 (n)
  • 83.09 (a)
(Monodelphis domestica)
Mammalia TJP3 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves TJP3 35
  • 67.11 (n)
  • 63.42 (a)
TJP3 36
  • 50 (a)
(Anolis carolinensis)
Reptilia TJP3 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11430 35
tjp3 35
  • 60.34 (n)
  • 61.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52795 35
(Danio rerio)
Actinopterygii Dr.21038 35
tjp3 36
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12768 35
fruit fly
(Drosophila melanogaster)
Insecta pyd 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea zoo-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for TJP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TJP3 Gene

Gene Tree for TJP3 (if available)
Gene Tree for TJP3 (if available)

Paralogs for TJP3 Gene

Paralogs for TJP3 Gene

(5) SIMAP similar genes for TJP3 Gene using alignment to 4 proteins: Pseudogenes for TJP3 Gene

genes like me logo Genes that share paralogs with TJP3: view

Variants for TJP3 Gene

Sequence variations from dbSNP and Humsavar for TJP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_056114 -
rs7256900 -- 3,728,550(+) GGGGA(C/G)ACCCT intron-variant
rs7257905 -- 3,749,973(+) GCCTC(A/G)GTTTT intron-variant
rs7258176 -- 3,730,043(+) CACAT(C/T)GTCAT reference, synonymous-codon
rs7259384 -- 3,724,441(+) ctgcc(C/T)gcctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TJP3 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3656n71 CNV Loss 21882294
dgv3660n71 CNV Loss 21882294
dgv3662n71 CNV Loss 21882294
nsv509718 CNV Insertion 20534489
nsv910768 CNV Loss 21882294
nsv910770 CNV Loss 21882294
dgv3663n71 CNV Loss 21882294
nsv910773 CNV Loss 21882294
nsv513509 CNV Insertion 21212237
nsv910775 CNV Loss 21882294

Variation tolerance for TJP3 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TJP3 Gene

Disorders for TJP3 Gene

Relevant External Links for TJP3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TJP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TJP3 Gene

Publications for TJP3 Gene

  1. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation. (PMID: 21411630) Capaldo C.T. … Nusrat A. (Mol. Biol. Cell 2011) 3
  5. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). (PMID: 18823282) Aho S. … Gruffat H. (Biol. Cell 2009) 3

Products for TJP3 Gene

Sources for TJP3 Gene