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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TJP3 Gene

protein-coding   GIFtS: 62
GCID: GC19P003708

Tight Junction Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tight Junction Protein 31 2 3     Zona Occludens 31
ZO32 3 5     ZO-32
Zona Occludens Protein 32 3     Tight Junction Protein 3 (Zona Occludens 3)2
Zonula Occludens Protein 32 3     Tight Junction Protein ZO-32

External Ids:    HGNC: 118291   Entrez Gene: 271342   Ensembl: ENSG000001052897   OMIM: 6126895   UniProtKB: O950493   

Export aliases for TJP3 gene to outside databases

Previous GC identifers: GC19P003820 GC19P003648 GC19P003679 GC19P003659 GC19P003493


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TJP3 Gene:
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein
family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate
kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a
basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the
linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions
during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This
gene has a partial pseudogene on chromosome 1. (provided by RefSeq, May 2012)

GeneCards Summary for TJP3 Gene: 
TJP3 (tight junction protein 3) is a protein-coding gene. Diseases associated with TJP3 include lung squamous cell carcinoma, and squamous cell carcinoma, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics and Cell adhesion Gap junctions. GO annotations related to this gene include protein binding. An important paralog of this gene is DLG5.

Gene Wiki entry for TJP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TJP3 gene promoter:
         c-Fos   AP-1   AP-2alpha isoform 3   ATF-2   c-Jun   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTJP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TJP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TJP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TJP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TJP3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003708:  view genomic region     (about GC identifiers)

Start:
3,708,107 bp from pter      End:
3,750,811 bp from pter
Size:
42,705 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZO3_HUMAN, O95049 (See protein sequence)
Recommended Name: Tight junction protein ZO-3  
Size: 933 amino acids; 102800 Da
Subunit: Interacts with occludin, claudins and ZO-1. Interacts with INADL (By similarity). Interacts with UBN1.
Interacts with FASLG
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction,
tight junction (By similarity)
1 PDB 3D structure from and Proteopedia for TJP3:
3KFV (3D)    
Secondary accessions: A6NFP3 B3KXZ0 K7EK22 Q32N01
Alternative splicing: 4 isoforms:  O95049-1   O95049-2   O95049-3   O95049-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TJP3: NX_O95049

Explore proteomics data for TJP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95049

  • TJP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TJP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001254489.1  NP_001254490.1  

    ENSEMBL proteins: 
     ENSP00000439278   ENSP00000468641   ENSP00000439991   ENSP00000465419   ENSP00000467864  
     ENSP00000465065   ENSP00000262968   ENSP00000371438  

    Human Recombinant Protein Products for TJP3: 
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    Cloud-Clone Corp. Proteins for TJP3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18823282
    GO:0005886plasma membrane ----
    GO:0005923tight junction IDA18823282
    GO:0016324apical plasma membrane IEA--

    TJP3 for ontologies           About GeneDecksing



    TJP3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR011511 SH3_2
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR027417 P-loop_NTPase
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O95049

    ProtoNet protein and cluster: O95049

    5 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB005417 Zona occludens protein family signature
    IPB005420 Zona occludens protein ZO-3 signature
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: ZO3_HUMAN, O95049
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 3 PDZ (DHR) domains
    Similarity: Contains 1 SH3 domain


    TJP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for TJP3:
    tight junction (zona occludens 3) protein ZO-3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18823282
         
    TJP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TJP3:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TJP3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TJP3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    2Cell adhesion Gap junctions
    Cell adhesion Gap junctions0.89
    3Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TJP3
        Cell adhesion Gap junctions
    Cell adhesion Tight junctions

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TJP3
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    2 Cell Signaling Technology (CST) Pathways for TJP3
        Cytoskeletal Signaling
    Adhesion

    2 GeneGo (Thomson Reuters) Pathways for TJP3
        Cell adhesion Tight junctions
    Cell adhesion Gap junctions


    1         Kegg Pathway  (Kegg details for TJP3):
        Tight junction


    TJP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TJP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for TJP3 (O950492, 3 ENSP000002629684) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INADLQ8NI352, 3, ENSP000003602004MINT-58720 MINT-58722 MINT-58721 I2D: score=2 STRING: ENSP00000360200
    TJP1Q071573, ENSP000002815374I2D: score=2 STRING: ENSP00000281537
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    GJC1P363833, ENSP000003331934I2D: score=2 STRING: ENSP00000333193
    OCLNQ166253, ENSP000003473794I2D: score=1 STRING: ENSP00000347379
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:2000045regulation of G1/S transition of mitotic cell cycle IEA--

    TJP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TJP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TJP3 (ZO3)

    2 Novoseek inferred chemical compound relationships for TJP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 39.3 2 9837755 (1), 12403786 (1)
    calcium 16.9 3 19176351 (1)

    Search CenterWatch for drugs/clinical trials and news about TJP3 / ZO3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TJP3 gene (3 alternative transcripts): 
    NM_001267560.1  NM_001267561.1  NM_014428.1  

    Unigene Cluster for TJP3:

    Tight junction protein 3
    Hs.25527  [show with all ESTs]
    Unigene Representative Sequence: NM_001267560
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541714(uc010xhs.2 uc010xht.2) ENST00000590545 ENST00000539908
    ENST00000587912 ENST00000589378 ENST00000587686 ENST00000591493 ENST00000586032
    ENST00000587641 ENST00000262968(uc010xhv.2 uc010xhw.2) ENST00000382008(uc010xhu.2)

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TJP3

    Additional mRNA sequence: 

    AK027292.1 AK091118.1 AK128237.1 AK304462.1 BC108906.2 BC108907.1 

    9 DOTS entries:

    DT.453921  DT.92421031  DT.121495834  DT.40253179  DT.92421034  DT.100776048  DT.92421028  DT.95342866 
    DT.87014942 

    24/100 AceView cDNA sequences (see all 100):

    AK128237 AA295512 BX110112 BQ690821 BM971550 BM981999 BU622551 AA399226 
    NM_014428 BX360391 AI708051 BV178772 BE733934 AK027292 AA405765 BX283645 
    BU850236 CB159368 BU931389 AK091118 BE903084 BM996064 BM830388 BF034304 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TJP3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
    SP1:                                      -                 -                                                                 -                                 
    SP2:                          -           -                 -                                                                                                   
    SP3:              -     -     -           -                 -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                          -           -                                                                                                                     

    ExUns: 20b ^ 21 ^ 22
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TJP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TJP3 expression in normal human tissues (normalized intensities)      TJP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCGGAGTC
    TJP3 Expression
    About this image


    TJP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
             colonic mucosal (ibs)   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
             trachea   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             nasopharynx ; respiratory epithelial cells   
             bronchial epithelia   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   

    See TJP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TJP3

    SOURCE GeneReport for Unigene cluster: Hs.25527
        SABiosciences Expression via Pathway-Focused PCR Arrays including TJP3: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TJP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TJP3 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TJP36
    tight junction protein 3
    49(a)
    1 ↔ 1
    28(991289-1002123)
    lizard
    (Anolis carolinensis)
    Reptilia TJP36
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL345029.1(652-13129)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC527952 similar to tight junction protein 3 (zona occludens more 72.96(n)    BC044322.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.210382 Danio rerio mRNA similar to tight junction protein more 72.66(n)    BC045978.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pyd6
    polychaetoid
    11(a)
    1 → many
    3R(4652790-4757599)
    worm
    (Caenorhabditis elegans)
    Secernentea zoo-16
    Protein ZOO-1, isoform a
    20(a)
    1 → many
    I(14529531-14546721)
            Species with no ortholog for TJP3

    ENSEMBL Gene Tree for TJP3 (if available)
    TreeFam Gene Tree for TJP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TJP3 gene
    DLG52  TJP22  TJP12  
    5 SIMAP similar genes for TJP3 using alignment to 6 protein entries:     ZO3_HUMAN (see all proteins):
    DKFZp686M05161    TJP2    TJP1    DLG4    DKFZp686A1195

    TJP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TJP3
    PGOHUM00000244128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1326 SNPs in TJP3 are shown (see all 1326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0561144
    ----see VAR_0561142 M T mis40--------
    rs798395691,2
    C,F--3470758(+) ATTGAG/ACACCT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1434205611,2
    --3706391(+) ACGACA/GAAGTC 1 -- us2k10--------
    rs721309211,2
    C--3706424(+) TTTAA-/TATT  
            
    TATTT
    1 -- us2k11Minor allele frequency- TATT:0.00CSA 2
    rs2020289851,2
    C--3706437(+) TATTTA/TTTTTT 1 -- us2k10--------
    rs675866851,2
    C--3706440(+) TATTT-/ATTT  
            
    TTCAG
    1 -- us2k11Minor allele frequency- ATTT:0.00NA 2
    rs43492741,2
    C,F--3706877(+) CCCAAC/TCCTTC 1 -- us2k13Minor allele frequency- T:0.18WA NA EA 358
    rs1378876011,2
    C--3706938(+) GGAGTA/GCAGTG 1 -- us2k10--------
    rs1918732551,2
    --3707062(+) AAAAAA/TGTTTT 1 -- us2k10--------
    rs1422127541,2
    C--3707182(+) ACTCCA/GTCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TJP3 (3708107 - 3750811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for TJP3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv513509CNV Insertion21212237
    nsv509718CNV Insertion20534489
    nsv910768CNV Loss21882294
    dgv3651n71CNV Loss21882294
    nsv910722CNV Loss21882294
    nsv910775CNV Loss21882294
    dgv3663n71CNV Loss21882294
    nsv470114CNV Loss18288195
    dgv3656n71CNV Loss21882294
    nsv910773CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612689    OMIM disorders: --

    6 diseases for TJP3:    About MalaCards
    lung squamous cell carcinoma    squamous cell carcinoma    retinitis    adenocarcinoma
    breast cancer    neuronitis


    TJP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TJP3

    Export disorders for TJP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TJP3 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with TJP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    2. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NaCos). (PubMed id 18823282)1, 2 Aho S.... Gruffat H. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Tight function zonula occludens-3 regulates cyclin D1 -dependent cell proliferation. (PubMed id 21411630)1 Capaldo C.T....Nusrat A. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27134 HGNC: 11829 AceView: TJP3 Ensembl:ENSG00000105289 euGenes: HUgn27134
    ECgene: TJP3 Kegg: 27134 H-InvDB: TJP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TJP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TJP3 gene:
    Search GeneIP for patents involving TJP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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