Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TJP3 Gene

protein-coding   GIFtS: 61
GCID: GC19P003708

Tight Junction Protein 3

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tight Junction Protein 31 2 3     Zona Occludens 31
ZO32 3 5     ZO-32
Zona Occludens Protein 32 3     Tight Junction Protein 3 (Zona Occludens 3)2
Zonula Occludens Protein 32 3     Tight Junction Protein ZO-32

External Ids:    HGNC: 118291   Entrez Gene: 271342   Ensembl: ENSG000001052897   OMIM: 6126895   UniProtKB: O950493   

Export aliases for TJP3 gene to outside databases

Previous GC identifers: GC19P003820 GC19P003648 GC19P003679 GC19P003659 GC19P003493


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TJP3 Gene:
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein
family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate
kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a
basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the
linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions
during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This
gene has a partial pseudogene on chromosome 1. (provided by RefSeq, May 2012)

GeneCards Summary for TJP3 Gene:
TJP3 (tight junction protein 3) is a protein-coding gene. An important paralog of this gene is DLG5.

Gene Wiki entry for TJP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TJP3 gene promoter:
         c-Fos   AP-1   AP-2alpha isoform 3   ATF-2   c-Jun   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTJP3 promoter sequence
   Search Chromatin IP Primers for TJP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TJP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TJP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TJP3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003708:  view genomic region     (about GC identifiers)

Start:
3,708,107 bp from pter      End:
3,750,811 bp from pter
Size:
42,705 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZO3_HUMAN, O95049 (See protein sequence)
Recommended Name: Tight junction protein ZO-3  
Size: 919 amino acids; 101397 Da
Subunit: Interacts with occludin, claudins and ZO-1. Interacts with INADL (By similarity). Interacts with UBN1.
Interacts with FASLG
Sequence caution: Sequence=AAC72274.1; Type=Erroneous gene model prediction; Sequence=EAW69293.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for TJP3:
3KFV (3D)    
Secondary accessions: A6NFP3 B3KR73 B3KXZ0 B4E2W6 F5H2X0 F5H4S9 K7EK22 Q32N01
Alternative splicing: 4 isoforms:  O95049-1   O95049-3   O95049-4   O95049-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TJP3: NX_O95049

Explore proteomics data for TJP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TJP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254489.1  NP_001254490.1  

    ENSEMBL proteins: 
     ENSP00000439278   ENSP00000468641   ENSP00000439991   ENSP00000465419   ENSP00000467864  
     ENSP00000465065   ENSP00000262968   ENSP00000371438  

    TJP3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TJP3
    OriGene Protein Over-expression Lysate for TJP3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TJP3
    GenScript Custom Purified and Recombinant Proteins Services for TJP3
    Novus Biologicals TJP3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TJP3

     
    Search eBioscience for Proteins for TJP3 

    TJP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TJP3  (ZO3)
    OriGene Antibodies for TJP3
    OriGene Custom Antibody Services for TJP3
    Novus Biologicals TJP3 Antibodies
    Abcam antibodies for TJP3
    Cloud-Clone Corp. Antibodies for TJP3
    ThermoFisher Antibodies for TJP3
    LSBio Antibodies in human, mouse, rat for TJP3

    TJP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TJP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TJP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TJP3
    Cloud-Clone Corp. CLIAs for TJP3
    Search eBioscience for ELISAs for TJP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 8):
     IPR011511 SH3_2
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR027417 P-loop_NTPase
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O95049

    ProtoNet protein and cluster: O95049

    5 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB005417 Zona occludens protein family signature
    IPB005420 Zona occludens protein ZO-3 signature
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: ZO3_HUMAN, O95049
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 3 PDZ (DHR) domains
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with TJP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for TJP3:
    tight junction (zona occludens 3) protein ZO-3

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18823282
         
    Find genes that share ontologies with TJP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TJP3:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TJP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TJP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TJP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TJP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TJP3:
    hsa-mir-335-5p (MIRT018043)

    Block miRNA regulation of human, mouse, rat TJP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TJP3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TJP3
    Predesigned siRNA for gene silencing in human, mouse, rat TJP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TJP3

    Clone
    Products:
         
    OriGene clones in human, mouse for TJP3 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TJP3 (NM_014428)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TJP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TJP3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TJP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TJP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TJP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZO3_HUMAN, O95049: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction,
    tight junction (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18823282
    GO:0005923tight junction IDA18823282
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with TJP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TJP3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    3Tight junction
    Tight junction
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Cell adhesion Gap junctions
    Cell adhesion Gap junctions


    Find genes that share SuperPaths with TJP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TJP3
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    2 Cell Signaling Technology (CST) Pathways for TJP3
        Cytoskeletal Signaling
    Adhesion

    2 GeneGo (Thomson Reuters) Pathways for TJP3
        Cell adhesion Tight junctions
    Cell adhesion Gap junctions


    1 Kegg Pathway  (Kegg details for TJP3):
        Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TJP3: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TJP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TJP3 (O950492, 3 ENSP000002629684) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INADLQ8NI352, 3, ENSP000003602004MINT-58720 MINT-58722 MINT-58721 I2D: score=2 STRING: ENSP00000360200
    TJP1Q071573, ENSP000002815374I2D: score=2 STRING: ENSP00000281537
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    GJC1P363833, ENSP000003331934I2D: score=2 STRING: ENSP00000333193
    OCLNQ166253, ENSP000003473794I2D: score=1 STRING: ENSP00000347379
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:2000045regulation of G1/S transition of mitotic cell cycle IEA--

    Find genes that share ontologies with TJP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TJP3 (ZO3)

    2 Novoseek inferred chemical compound relationships for TJP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 39.3 2 9837755 (1), 12403786 (1)
    calcium 16.9 3 19176351 (1)



    Find genes that share compounds with TJP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TJP3 gene (3 alternative transcripts): 
    NM_001267560.1  NM_001267561.1  NM_014428.1  

    Unigene Cluster for TJP3:

    Tight junction protein 3
    Hs.25527  [show with all ESTs]
    Unigene Representative Sequence: NM_001267560
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541714(uc010xhs.2 uc010xht.2) ENST00000590545 ENST00000539908
    ENST00000587912 ENST00000589378 ENST00000587686 ENST00000591493 ENST00000586032
    ENST00000587641 ENST00000262968(uc010xhv.2 uc010xhw.2) ENST00000382008(uc010xhu.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TJP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TJP3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TJP3
    Predesigned siRNA for gene silencing in human, mouse, rat TJP3
    Clone
    Products:
         
    OriGene clones in human, mouse for TJP3 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TJP3 (NM_014428)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TJP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TJP3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TJP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TJP3
      QuantiTect SYBR Green Assays in human, mouse, rat TJP3
      QuantiFast Probe-based Assays in human, mouse, rat TJP3

    Additional mRNA sequence: 

    AK027292.1 AK091118.1 AK128237.1 AK304462.1 BC108906.2 BC108907.1 

    9 DOTS entries:

    DT.453921  DT.92421031  DT.121495834  DT.40253179  DT.92421034  DT.100776048  DT.92421028  DT.95342866 
    DT.87014942 

    Selected AceView cDNA sequences (see all 100):

    BM981999 AK128237 BX110112 BM971550 NM_014428 BU622551 BQ690821 AA295512 
    AA399226 BE253498 BU679373 BU682910 BG471572 AK027292 CB242852 CB996691 
    BE741330 BQ187651 BE903084 BX339213 BX283645 AA405765 BU931389 AA284936 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TJP3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
    SP1:                                      -                 -                                                                 -                                 
    SP2:                          -           -                 -                                                                                                   
    SP3:              -     -     -           -                 -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                          -           -                                                                                                                     

    ExUns: 20b ^ 21 ^ 22
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TJP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TJP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCGGAGTC
    TJP3 Expression
    About this image

    TJP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TJP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25527
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TJP3: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TJP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TJP3
    QuantiTect SYBR Green Assays in human, mouse, rat TJP3
    QuantiFast Probe-based Assays in human, mouse, rat TJP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TJP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TJP3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tjp31 tight junction protein 3 80.02(n)
    82.89(a)
      27375  NM_001282096.1  NP_001269025.1 
    chicken
    (Gallus gallus)
    Aves TJP31 tight junction protein 3 (zona occludens 3) 67.11(n)
    63.42(a)
      420070  XM_003642840.2  XP_003642888.2 
    lizard
    (Anolis carolinensis)
    Reptilia TJP36
    tight junction protein 3
    56(a)
    1 ↔ 1
    GL345029.1(652-13129)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC527952 similar to tight junction protein 3 (zona occludens more 72.96(n)    BC044322.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.210382 Danio rerio mRNA similar to tight junction protein more 72.66(n)    BC045978.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pyd6
    polychaetoid
    12(a)
    1 → many
    3R(4652790-4757599)
    worm
    (Caenorhabditis elegans)
    Secernentea zoo-16
    Protein ZOO-1, isoform a
    21(a)
    1 → many
    I(14529531-14546721) WBGene00013683


    ENSEMBL Gene Tree for TJP3 (if available)
    TreeFam Gene Tree for TJP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TJP3 gene
    DLG52  TJP22  TJP12  
    5 SIMAP similar genes for TJP3 using alignment to 4 protein entries:     ZO3_HUMAN (see all proteins):
    DKFZp686M05161    TJP2    DLG4    TJP1    DKFZp686A1195

    Find genes that share paralogs with TJP3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TJP3
    PGOHUM00000244128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TJP3 (see all 1326)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798395691,2
    C,F--3470758(+) ATTGAG/ACACCT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1434205611,2
    --3706391(+) ACGACA/GAAGTC 1 -- us2k10--------
    rs721309211,2
    C--3706424(+) TTTAA-/TATT  
            
    TATTT
    1 -- us2k11Minor allele frequency- TATT:0.00CSA 2
    rs2020289851,2
    C--3706437(+) TATTTA/TTTTTT 1 -- us2k10--------
    rs675866851,2
    C--3706440(+) TATTT-/ATTT  
            
    TTCAG
    1 -- us2k11Minor allele frequency- ATTT:0.00NA 2
    rs43492741,2
    C,F--3706877(+) CCCAAC/TCCTTC 1 -- us2k13Minor allele frequency- T:0.18WA NA EA 358
    rs1378876011,2
    C--3706938(+) GGAGTA/GCAGTG 1 -- us2k10--------
    rs1918732551,2
    --3707062(+) AAAAAA/TGTTTT 1 -- us2k10--------
    rs1422127541,2
    C--3707182(+) ACTCCA/GTCTCT 1 -- us2k10--------
    rs1463997001,2
    C--3707194(+) CAAAAA/GTACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TJP3 (3708107 - 3750811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TJP3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513509CNV Insertion21212237
    nsv509718CNV Insertion20534489
    nsv910768CNV Loss21882294
    dgv3651n71CNV Loss21882294
    nsv910722CNV Loss21882294
    nsv910775CNV Loss21882294
    dgv3663n71CNV Loss21882294
    nsv470114CNV Loss18288195
    dgv3656n71CNV Loss21882294
    nsv910773CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TJP3
    DNA2.0 Custom Variant and Variant Library Synthesis for TJP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612689    OMIM disorders: --


    Find genes that share disorders with TJP3           About GenesLikeMe

    Genetic Association Database (GAD): TJP3

    Export disorders for TJP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TJP3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with TJP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    2. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). (PubMed id 18823282)1, 2 Aho S.... Gruffat H. (Biol. Cell 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation. (PubMed id 21411630)1 Capaldo C.T....Nusrat A. (Mol. Biol. Cell 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27134 HGNC: 11829 AceView: TJP3 Ensembl:ENSG00000105289 euGenes: HUgn27134
    ECgene: TJP3 Kegg: 27134 H-InvDB: TJP3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TJP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TJP3 gene:
    Search GeneIP for patents involving TJP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TJP3   OriGene RNAi products in human, mouse, rat for TJP3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TJP3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TJP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TJP3   OriGene Purified Protein for TJP3  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TJP3   OriGene Custom Protein Services for TJP3  

     
     
     Block miRNA regulation of human, mouse, rat TJP3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TJP3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TJP3 Predesigned siRNA for gene silencing in human, mouse, rat TJP3
     QuantiFast Probe-based Assays in human, mouse, rat TJP3 QuantiTect SYBR Green Assays in human, mouse, rat TJP3
     PCR Arrays including human, mouse, rat TJP3 Search Chromatin IP Primers for TJP3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TJP3  GeneGlobe Interaction Network for TJP3
     Regulatory tfbs in TJP3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TJP3 GenScript cDNA clones with any tag delivered in your preferred vector for TJP3
     GenScript Custom Assay Services for TJP3 GenScript Custom overexpressing Cell Line Services for TJP3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TJP3  (ZO3)

     Search Tocris compounds for TJP3 (ZO3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TJP3 antibodies
     TJP3 proteins
     Antibodies for TJP3
     See all of Abcam's Antibodies, Kits and Proteins for TJP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TJP3
     Antibodies for TJP3
     ELISAs for TJP3
     CLIAs for TJP3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TJP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TJP3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TJP3
     SwitchGear Promoter luciferase reporter plasmids for TJP3
     ThermoFisher Antibodies for TJP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TJP3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TJP3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TJP3
     LSBio Antibodies in human, mouse, rat for TJP3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TJP3
      Search eBioscience for proteins for TJP3
      Search eBioscience for elisas for TJP3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TJP3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4