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TJP2 Gene

protein-coding GIFtS: 63

GC09P070956

tight junction protein 2 (zona occludens 2)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC26306 ^²
OTTHUMP00000021431 ^²
OTTHUMP00000063359 ^²
X104 ^¹, ², ³
ZO-2 ^¹, ²
ZO2 ^¹, ², ³, ⁵

Descriptions
Friedreich ataxia region gene X104 (tight junction protein ZO-2) ^²
Tight junction protein 2 ^³
Zona occludens protein 2 ^³
Zonula occludens protein 2 ^³
tight junction protein 2 (zona occludens 2) ^²

External Ids
HGNC: 11828¹
Entrez Gene: 9414²
UniProtKB: Q9UDY2³
Ensembl: ENSG00000119139⁷

Search outside databases for aliases for TJP2 gene

Previous GC identifers: GC09P062833 GC09P063592 GC09P065359 GC09P067246 GC09P067193 GC09P068965

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TJP2:

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK)

homologs that are involved in the organization of epithelial and endothelial intercellular

junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link

them to the actin cytoskeleton.[supplied by OMIM]

UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2

Function: Plays a role in tight junctions and adherens junctions

Gene Wiki entry for TJP2 (Tight_junction_protein_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TJP2 gene

Entrez Gene cytogenetic band: 9q13-q21 Ensembl cytogenetic band: 9q21.11 HGNC cytogenetic band: 9q13-q21

TJP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P070956: (about GC identifiers)

Start:	70,956,382 bp from pter
End:	71,059,940 bp from pter
Size:	103,559 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2 (See protein sequence)

Recommended Name: Tight junction protein ZO-2

Size: 1190 amino acids; 133972 Da

Subunit: Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction

with SAFB occurs in the nucleus

Subcellular location: Cell junction, adherens junction. Cell membrane; Peripheral membrane protein;

Cytoplasmic side (By similarity). Cell junction, tight junction (By similarity). Nucleus (By

similarity). Note=Also nuclear under environmental stress conditions and in migratory endothelial

cells and subconfluent epithelial cell cultures (By similarity)

Sequence caution: Sequence=AAA61300.1; Type=Frameshift; Positions=1086, 1092, 1095;

PDB structures from and Proteopedia :

2OSG (3D)

Secondary accessions: Q15883 Q5VXL0 Q8N756 Q8NI14 Q99839 Q9UDY0 Q9UDY1

Alternative promoter usage, Alternative splicing: 5 isoforms: Q9UDY2-1 Q9UDY2-2 Q9UDY2-5 Q9UDY2-3 Q9UDY2-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004808.2 NP_963923.1

ENSEMBL proteins:

ENSP00000265384 ENSP00000366469 ENSP00000366453 ENSP00000345893

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TJP2)
	Human Recombinant Proteins from Abnova (TJP2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IEA	--
GO:0005923	tight junction	IEA	--
GO:0030054	cell junction	IEA	--

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Antibodies for TJP2:

	Invitrogen Antibodies for TJP2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TJP2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TJP2 (ZO-2)
	Antibodies from Abcam (TJP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TJP2)
	Novus Biologicals Antibody for TJP2

Assays for TJP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UDY2

ProtoNet protein and cluster: Q9UDY2

5/6 Blocks protein families (see all 6 ):

IPB001452 SH3 domain signature

IPB001478 PDZ/DHR/GLGF domain

IPB005417 Zona occludens protein family signature

IPB005419 Zona occludens protein ZO-2 signature

IPB008144 Guanylate kinase

UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 3 PDZ (DHR) domains

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TJP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TJP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004817

Applied Biosystems Silencer® siRNAs for TJP2

Sigma-Aldrich siRNA and siRNA Panels for TJP2

Sigma-Aldrich shRNA for TJP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004817
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004817
untagged cDNA clones in CMV expression vector (see all 4): AK025185

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004817

UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2

Function: Plays a role in tight junctions and adherens junctions

Genatlas biochemistry entry for TJP2:

tight junction (zona occludens) protein ZO-2,homolog to yeast guanylate kinase and Drosophila

lethal discs large tumor suppressor protein (Dlg),interacting with occludin,TJP1,the F actin

skeleton and alpha catenin

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tjp2):

cellular

embryogenesis

growth/size

lethality-prenatal/perinatal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004385	guanylate kinase activity	TAS	8824195
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for TJP2 (Your Favorite Gene powered by Ingenuity)

Purine Metabolism
Tight Junction Signaling
Hepatic Cholestasis

GeneDecks TJP2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TJP2

5/61 Interacting proteins for TJP2 (Q9UDY2^{1, 2} ENSP00000366453³) via UniProtKB, MINT, and/or STRING (see all 61 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TJP1	Q07157², ENSP00000281537³	MINT-6800622 STRING (score=.996)
YWHAB	P31946¹^,²	EBI-1042602, EBI-359815 MINT-50953 EBI-1042602, EBI-359815 MINT-50953
YWHAG	P61981¹^,²	EBI-1042602, EBI-359832 MINT-50823 EBI-1042602, EBI-359832 MINT-50823
YWHAZ	P63104¹^,²	EBI-1042602, EBI-347088 MINT-51022 EBI-1042602, EBI-347088 MINT-51022
TRAF6	Q9Y4K3¹	EBI-1042602, EBI-359276

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TJP2
4 Novoseek chemical compound relationships for TJP2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	57.41	4	8566365 (1), 9837755 (1), 12403786 (1), 11716757 (1)
calcium	15.00	4	8408213 (1), 10883394 (1), 19176351 (1)
atp	0.00	3	10330056 (3)
tyrosine	0.00	4	10330056 (2), 7542259 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TJP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TJP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004817

Sigma-Aldrich siRNA and siRNA Panels for TJP2

Sigma-Aldrich shRNA for TJP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004817 NM_201629

REFSEQ mRNAs for TJP2 gene (2 alternative transcripts):

NM_004817.2 NM_201629.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004817 NM_201629

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004817
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004817
                                 untagged cDNA clones in CMV expression vector (see all 4): AK025185

Additional cDNA sequence:

AB209630.1 AF083892.1 AF083893.1 AF489824.1 AK295016.1 AK295034.1 AK302483.1 AK304447.1

AK307697.1 AK308564.1 BC027592.1 BC028426.1 L27476.1 U84581.1

24 DOTS entries:

DT.454601 DT.101980037 DT.100822240 DT.95174262 DT.100036395 DT.40220809 DT.102832607 DT.121157064

DT.91761503 DT.121157078 DT.100822241 DT.121157018 DT.121157065 DT.40115922 DT.95174266 DT.100822239

DT.102832604 DT.121157037 DT.121157041 DT.121157112 DT.95174254 DT.95336235 DT.305712 DT.92050174

24/319 AceView cDNA sequences (see all 319 ):

CA425756 CK904464 AI343382 AI521523 BF063122 BG538728 AW272483 AA781310

AV650575 AI276186 AI424882 CB153750 AV650602 AV654365 BM982533 CK904463

AI479213 AF083893 AW950623 BU662676 AU142000 BX464881 AI363319 BX116223

highest scoring ESTs for TJP2:

L27476 AA019402 AA055550 AA056766 AA058385 AA058416 AA058444 AA058469 AA088283 AA088401

Unigene Cluster for TJP2:

Tight junction protein 2 (zona occludens 2)

Hs.50382 [show with all ESTs]

Unigene Representative Sequence: AB209630

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for TJP2 (see all 16 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	·	13c	·	13d	^	14	^	15	^	16	^	17	^	18	^
SP1:															-		-		-		-										-		-
SP2:															-		-		-		-										-		-
SP3:											-		-		-		-		-		-										-		-
SP4:											-		-				-		-		-
SP5:																			-		-										-		-

ExUns:	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25a	·	25b	·	25c	^	26a	·	26b	^	27a	·	27b	·	27c	^	28	^	29a	·	29b	^	30	^	31a	·	31b	·	31c	^	32a	·	32b
SP1:	-																				-		-								-				-								-		-
SP2:	-																				-		-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TJP2

4 Ensembl transcripts including schematic representations:

ENST00000265384 ENST00000377259 ENST00000377245 ENST00000348208

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TJP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TJP2

¹ / ² / ³

8 probe-sets matching TJP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36655_at²^{, 3}	U95-A	1	1.00	1.00	0.90	1.47	L27476	1.00	1.00	1.00	1
54505_at²^{, 3}	U95-B	1	1.00	1.00	0.86	0.56	AA161241	0.80	1.00	0.91	1
202085_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004817	0.60	1.00	0.82	1
232017_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK025185	0.40	1.00	0.76	1
242991_at²^{, 3}	U133-B	1	0.64	1.00	--	--	BE501903	0.60	1.00	0.82	1
202085_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232017_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242991_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

GeneDecks TJP2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATTGACAAC

SOURCE GeneReport for Unigene cluster: Hs.50382
Expression variation in blood from EXPOLDB for TJP2
UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2
Tissue specificity: This protein is found in epithelial cell junctions. Isoform A1 is abundant in
the heart and brain whereas isoform C1 is expressed at high level in the kidney, pancreas, heart
and placenta. In brain and skeletal muscle, only isoform A1 is detectable. Isoform C1 is found in
normal as well as in most neoplastic tissues while isoform A1 is present almost exclusively in
normal tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for TJP2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TJP2¹	--	tight junction protein 2 (zona occludens 2)	89.78(n) 90.61(a)	403854 NM_001003204.1 NP_001003204.1
chimpanzee (Pan troglodytes)	TJP2¹	--	tight junction protein 2 (zona occludens 2)	99.44(n) 99.49(a)	464514 XM_520061.2 XP_520061.2
cow (Bos taurus)	TJP2¹	--	tight junction protein 2 (zona occludens 2)	88.92(n) 90.49(a)	407101 XM_873993.2 XP_879086.2
rat (Rattus norvegicus)	Tjp2¹	--	tight junction protein 2	84.91(n) 87.51(a)	115769 NM_053773.1 NP_446225.1
mouse (Mus musculus)	Tjp2^{1, 5}	19⁵	tight junction protein 2^{1, 5}	84.1(n)¹ 86.23(a)¹	21873¹ NM_011597.2¹ NP_035727.1¹ AF113005⁵ AK028494⁵ (see all 24)

About this table Species with no ortholog for TJP2

ENSEMBL Gene Tree for TJP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for TJP2 gene

TJP3² DLG5² TJP1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/681 NCBI SNPs in TJP2 are shown (see all 681 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 199)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2309428^1,2	A,C,F,H	71032843(+)	`GAGGAA/CCCCCC`	2	D/E	mis¹ ese³		12		EU EA WA	1256
	rs1416738^1,2	A,C,F,H	70977747(+)	`AGAGGC/TGTGGA`	2	--	ng5¹		12		NS EU EA WA NA	756
	rs3812536^1,2	A,C,F,H	71059293(-)	`ACAAAT/CAGAGC`	2	--	ut3¹ ese³		5		EA EU WA	1914
	rs4558^1,2	C,F,H	71059730(+)	`CATAAA/TTTTGG`	2	--	ut3¹		9		MN EU EA WA	1010
--	rs953812^1,2	A,C	70977451(+)	`tttatC/Tttttt`	2	--	ng5¹ trp³		0	--	--	--	--
	rs1049625^1,2	C,H	71044802(+)	`GGTTAA/GATCCA`	2	N/D	mis¹ ese³		9		MN EU EA WA	992
--	rs7860124^1,2	A,C	70978769(+)	`tcccgA/Cccccg`	2	--	ng5¹		0	--	--	--	--
	rs34774441^1,2	C,F	71041697(+)	`CAAATG/AGCCAG`	2	I/M	mis¹		5		NA EU EA WA	492
	rs35797487^1,2	C,F	71041824(+)	`TTGTGT/CCTGTC`	2	P/S	mis¹		5		NA EU EA WA	492
	rs1049627^1,2	H	71044843(+)	`GATCAA/CGCCAA`	2	Q/H	mis¹		5		MN EU EA WA	590

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HapMap Linkage Disequilibrium images for TJP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 607709 disorders: 607748

UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2

Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a

disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption

5 Novoseek disease relationships for TJP2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma	16.32	5	10360833 (1), 11018256 (1), 17585317 (1), 10495427 (1)
cancer	0.00	1	11018256 (1)
carcinoma	0.00	1	10495427 (1)
breast cancer	0.00	1	15571953 (1)
tumors	0.00	4	7590743 (1), 8132716 (1), 7485497 (1)

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Human Gene Mutation Database: TJP2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/119 PubMed articles for TJP2 gene (see all 119 ):

The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb. (PubMed id 7951235)^{2, 3, 4} Duclos F.... Koenig M. (1994)
Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. (PubMed id 12704386)^{1, 3, 4} Carlton V.E.H.... Bull L.N. (2003)
Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues. (PubMed id 11018256)^{1, 3, 4} Chlenski A....Scarpelli D.G. (2000)
Zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells. (PubMed id 10495427)^{1, 3, 4} Chlenski A.... Scarpelli D.G. (1999)
Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma. (PubMed id 10360833)^{1, 3, 4} Chlenski A.... Scarpelli D.G. (1999)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9414	HGNC: 11828	AceView: TJP2	Ensembl:ENSG00000119139	euGenes: HUgn9414
ECgene: TJP2	H-InvDB: TJP2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for TJP2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TJP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TJP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TJP2		Antibodies for TJP2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TJP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TJP2)
	Antibodies (TJP2)
	Chimera RNAi (TJP2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TJP2 (ZO-2)

	Recombinant Proteins (TJP2)
	Antibodies (TJP2)

Search OriGene for TJP2

Search Tocris compounds for TJP2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TJP2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TJP2 Gene at Home site.
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TJP2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for TJP2

Summaries
for TJP2

Genomic Location
for TJP2

Proteins
for TJP2

Protein Domains/
Families
for TJP2

Gene Function
for TJP2

Pathways & Interactions
for TJP2

Drugs & Compounds
for TJP2

Transcripts
for TJP2

Expression
for TJP2

Orthologs
for TJP2

Paralogs
for TJP2

SNPs/Variants
for TJP2

Disorders & Mutations
for TJP2

Medical News
for TJP2

Publications
for TJP2

Search for TJP2

Genome Databases showing TJP2

Other Databases showing TJP2

Specialized Databases showing TJP2

Licensable Technologies
for TJP2

Services
for TJP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TJP2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor TJP2

Summariesfor TJP2

Genomic Locationfor TJP2

Proteinsfor TJP2

Protein Domains/Familiesfor TJP2

Gene Functionfor TJP2

Pathways & Interactionsfor TJP2

Drugs & Compoundsfor TJP2

Transcriptsfor TJP2

Expression for TJP2

Orthologsfor TJP2

Paralogsfor TJP2

SNPs/Variantsfor TJP2

Disorders & Mutationsfor TJP2

Medical Newsfor TJP2

Publicationsfor TJP2

Search for TJP2

Genome Databases showing TJP2

Other Databases showing TJP2

Specialized Databases showing TJP2

Licensable Technologiesfor TJP2

Servicesfor TJP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TJP2

Summaries
for TJP2

Genomic Location
for TJP2

Proteins
for TJP2

Protein Domains/
Families
for TJP2

Gene Function
for TJP2

Pathways & Interactions
for TJP2

Drugs & Compounds
for TJP2

Transcripts
for TJP2

Expression
for TJP2

Orthologs
for TJP2

Paralogs
for TJP2

SNPs/Variants
for TJP2

Disorders & Mutations
for TJP2

Medical News
for TJP2

Publications
for TJP2

Licensable Technologies
for TJP2

Services
for TJP2