Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TJP2 Gene

protein-coding   GIFtS: 66
GCID: GC09P071766

Tight Junction Protein 2

(Previous names: deafness, autosomal dominant 51)
(Previous symbol: DFNA51)
  See TJP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tight Junction Protein 21 2 3     X1042 3
ZO22 3 5     Deafness, Autosomal Dominant 511
DFNA511 2     C9DUPq21.112
Friedreich Ataxia Region Gene X104 (Tight Junction Protein ZO-2)1 2     DUP9q21.112
Zona Occludens 21 2     Tight Junction Protein ZO-22
Zonula Occludens Protein 22 3     Zona Occludens Protein 23

External Ids:    HGNC: 118281   Entrez Gene: 94142   Ensembl: ENSG000001191397   OMIM: 6077095   UniProtKB: Q9UDY23   
ORGUL members:         

Export aliases for TJP2 gene to outside databases

Previous GC identifers: GC09P062833 GC09P063592 GC09P065359 GC09P067246 GC09P067193 GC09P068965 GC09P070956 GC09P041580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TJP2 Gene:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family.
The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells
and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients
with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant
deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Nov 2011)

GeneCards Summary for TJP2 Gene:
TJP2 (tight junction protein 2) is a protein-coding gene. Diseases associated with TJP2 include cholestasis, progressive familial intrahepatic 4, and deafness, autosomal dominant 51. GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is DLG5.

UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2
Function: Plays a role in tight junctions and adherens junctions

Gene Wiki entry for TJP2 (Tight junction protein 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TJP2 gene promoter:
         AP-1   p53   ATF-2   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTJP2 promoter sequence
   Search Chromatin IP Primers for TJP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TJP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13-q21   Ensembl cytogenetic band:  9q21.11   HGNC cytogenetic band: 9q13-q21

TJP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TJP2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P071766:  view genomic region     (about GC identifiers)

Start:
71,736,209 bp from pter      End:
71,870,124 bp from pter
Size:
133,916 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2 (See protein sequence)
Recommended Name: Tight junction protein ZO-2  
Size: 1190 amino acids; 133958 Da
Subunit: Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs
in the nucleus. Interacts with SCRIB
Sequence caution: Sequence=AAA61300.1; Type=Frameshift; Positions=1086, 1092, 1095;
2 PDB 3D structures from and Proteopedia for TJP2:
2OSG (3D)        3E17 (3D)    
Secondary accessions: A2A3H9 B7Z2R8 B7Z7T6 F5H301 F5H886 Q15883 Q5VXL0 Q5VXL1 Q8N756 Q8NI14
Q99839 Q9UDY0 Q9UDY1
Alternative promoter usage, Alternative splicing: 7 isoforms:  Q9UDY2-1   Q9UDY2-2   Q9UDY2-5   Q9UDY2-3   Q9UDY2-4   Q9UDY2-6   Q9UDY2-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TJP2: NX_Q9UDY2

Explore proteomics data for TJP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1016
  • Modification sites at PhosphoSitePlus

  • See TJP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001163885.1  NP_001163886.1  NP_001163887.1  NP_001164101.1  NP_004808.2  NP_963923.1  

    ENSEMBL proteins: 
     ENSP00000475926   ENSP00000366469   ENSP00000402941   ENSP00000366453   ENSP00000345893  
     ENSP00000265384   ENSP00000442090   ENSP00000438262   ENSP00000392178  
    Reactome Protein details: Q9UDY2

    TJP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TJP2
    OriGene Protein Over-expression Lysate for TJP2
    OriGene MassSpec for TJP2
    OriGene Custom Protein Services for TJP2
    GenScript Custom Purified and Recombinant Proteins Services for TJP2
    Novus Biologicals TJP2 Protein
    Novus Biologicals TJP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TJP2

     
    Search eBioscience for Proteins for TJP2 

     
    antibodies-online proteins for TJP2 (2 products) 

     
    antibodies-online peptides for TJP2

    TJP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TJP2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TJP2  (ZO2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TJP2
    Novus Biologicals TJP2 Antibodies
    Abcam antibodies for TJP2
    Cloud-Clone Corp. Antibodies for TJP2
    ThermoFisher Antibodies for TJP2
    LSBio Antibodies in human, mouse, rat for TJP2
    antibodies-online antibodies for TJP2 (61 products) 

    TJP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TJP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TJP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TJP2
    Cloud-Clone Corp. CLIAs for TJP2
    Search eBioscience for ELISAs for TJP2 
    antibodies-online kits for TJP2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 8):
     IPR011511 SH3_2
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR027417 P-loop_NTPase
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9UDY2

    ProtoNet protein and cluster: Q9UDY2

    Selected Blocks protein domains (see all 6):
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB005417 Zona occludens protein family signature
    IPB005419 Zona occludens protein ZO-2 signature
    IPB008144 Guanylate kinase


    UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 3 PDZ (DHR) domains
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with TJP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZO2_HUMAN, Q9UDY2
    Function: Plays a role in tight junctions and adherens junctions

         Genatlas biochemistry entry for TJP2:
    tight junction (zona occludens) protein ZO-2,homolog to yeast guanylate kinase and Drosophila lethal discs large
    tumor suppressor protein (Dlg),interacting with occludin,TJP1,the F actin skeleton and alpha catenin

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS8824195
    GO:0005515protein binding IPI15975580
    GO:0008022protein C-terminus binding IEA--
         
    Find genes that share ontologies with TJP2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for TJP2:
     Decreased Hepatitis C virus re  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  G0/1 arrest 
     Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tjp2):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with TJP2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TJP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TJP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TJP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TJP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TJP2:
    hsa-mir-34a-5p (MIRT025356), hsa-mir-192-5p (MIRT026686), hsa-mir-203a (MIRT006684), hsa-mir-215-5p (MIRT024740), hsa-mir-193b-3p (MIRT016495), hsa-mir-124-3p (MIRT002718)

    Block miRNA regulation of human, mouse, rat TJP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TJP2 (see all 14):
    hsa-miR-498 hsa-miR-3163 hsa-miR-520d-5p hsa-miR-130a* hsa-miR-2110 hsa-miR-23c hsa-miR-181a-2* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidTJP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TJP2
    Predesigned siRNA for gene silencing in human, mouse, rat TJP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TJP2

    Clone
    Products:
         
    OriGene clones in human, mouse for TJP2 (see all 30)
    OriGene ORF clones in mouse, rat for TJP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TJP2 (NM_201629)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TJP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TJP2
    Addgene plasmids for TJP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TJP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TJP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TJP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZO2_HUMAN, Q9UDY2: Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic
    side (By similarity). Cell junction, tight junction (By similarity). Nucleus (By similarity). Note=Also nuclear
    under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell
    cultures (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus4
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005912adherens junction IEA--

    Find genes that share ontologies with TJP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TJP2 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Apoptotic cleavage of cell adhesion proteins0.00
    Apoptotic execution phase0.74
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Signaling by GPCR
    Signal Transduction0.58
    4Insulin receptor recycling
    Vibrio cholerae infection0.40
    5CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.38


    Find genes that share SuperPaths with TJP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TJP2
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Signaling in Gap Junctions

    1 Cell Signaling Technology (CST) Pathway for TJP2
        Adhesion

    3 GeneGo (Thomson Reuters) Pathways for TJP2
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions
    Cell adhesion Gap junctions

    1 BioSystems Pathway for TJP2
        Validated targets of C-MYC transcriptional repression

    2 Reactome Pathways for TJP2
        Signaling by Hippo
    Apoptotic cleavage of cell adhesion proteins


    2 Kegg Pathways  (Kegg details for TJP2):
        Tight junction
    Vibrio cholerae infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TJP2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TJP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TJP2 (Q9UDY21, 2, 3 ENSP000003664534) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50953 I2D: score=4 STRING: ENSP00000300161
    YWHAGP619812, 3, ENSP000003063304MINT-50823 I2D: score=4 STRING: ENSP00000306330
    TJP1Q071572, 3, ENSP000002815374MINT-6800622 I2D: score=3 STRING: ENSP00000281537
    BCRP112742, 3, ENSP000003035074MINT-69540 I2D: score=1 STRING: ENSP00000303507
    WWTR1Q9GZV52, 3, ENSP000003538474MINT-7995020 I2D: score=1 STRING: ENSP00000353847
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0010033response to organic substance IEA--
    GO:0035329hippo signaling TAS--
    GO:0046939nucleotide phosphorylation TAS8824195

    Find genes that share ontologies with TJP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TJP2 (ZO2)

    4 Novoseek inferred chemical compound relationships for TJP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 55.8 4 8566365 (1), 9837755 (1), 12403786 (1), 11716757 (1)
    calcium 12.7 5 8408213 (1), 10883394 (1), 19176351 (1)
    atp 0 3 10330056 (3)
    tyrosine 0 4 10330056 (2), 7542259 (1)



    Find genes that share compounds with TJP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TJP2 gene (6 alternative transcripts): 
    NM_001170414.2  NM_001170415.1  NM_001170416.1  NM_001170630.1  NM_004817.3  NM_201629.3  

    Unigene Cluster for TJP2:

    Tight junction protein 2
    Hs.50382  [show with all ESTs]
    Unigene Representative Sequence: NM_004817
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413932 ENST00000606364 ENST00000377259 ENST00000423935 ENST00000377245(uc004ahe.3 uc004ahf.3)
    ENST00000348208(uc010mom.1) ENST00000265384(uc004ahd.3) ENST00000498204
    ENST00000535702(uc011lru.2) ENST00000539225(uc011lrv.2) ENST00000453658(uc004ahb.1 uc011lrt.1 uc011lrs.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TJP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TJP2 (see all 14):
    hsa-miR-498 hsa-miR-3163 hsa-miR-520d-5p hsa-miR-130a* hsa-miR-2110 hsa-miR-23c hsa-miR-181a-2* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidTJP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TJP2
    Predesigned siRNA for gene silencing in human, mouse, rat TJP2
    Clone
    Products:
         
    OriGene clones in human, mouse for TJP2 (see all 30)
    OriGene ORF clones in mouse, rat for TJP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TJP2 (NM_201629)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TJP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TJP2
    Addgene plasmids for TJP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TJP2
    OriGene qSTAR qPCR primer pairs in human, mouse for TJP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TJP2
      QuantiTect SYBR Green Assays in human, mouse, rat TJP2
      QuantiFast Probe-based Assays in human, mouse, rat TJP2

    Additional mRNA sequence: 

    AF083892.1 AF083893.1 AF489824.1 AK295016.1 AK295034.1 AK302483.1 AK304447.1 AK307697.1 
    AK308564.1 BC027592.1 BC028426.1 L27476.1 U84581.1 

    24 DOTS entries:

    DT.454601  DT.101980037  DT.100822240  DT.95174262  DT.100036395  DT.40220809  DT.102832607  DT.121157064 
    DT.91761503  DT.121157078  DT.100822241  DT.121157018  DT.121157065  DT.40115922  DT.95174266  DT.100822239 
    DT.102832604  DT.121157037  DT.121157041  DT.121157112  DT.305712  DT.95174254  DT.92050174  DT.95336235 

    Selected AceView cDNA sequences (see all 319):

    CB153750 AW950623 BE327034 AW662702 CB161675 AI354289 NM_004817 CA425756 
    CA449797 AW276574 BM982533 AA781310 BQ231737 AW002261 CB161832 BE501903 
    CA426497 BM837618 BM974356 AI424882 BX464881 BX116223 AF083892 AV650602 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TJP2 (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                            -     -     -     -                             -     -                                                         
    SP2:                                            -     -     -     -                             -     -                                                         
    SP3:                                -     -     -     -     -     -                             -     -                                                         
    SP4:                                -     -           -     -     -                                                                                             
    SP5:                                                        -     -                             -     -                                                         

    ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b · 27c ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b · 31c ^ 32a · 32b
    SP1:  -                                                           -     -                       -           -                       -     -               
    SP2:  -                                                           -     -                                                                                 
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for TJP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TJP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGACAAC
    TJP2 Expression
    About this image


    TJP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             Early Ameloblasts Dental Enamel
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
    TJP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TJP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50382

    UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2
    Tissue specificity: This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and
    brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is
    expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle.
    Found in normal as well as in most neoplastic tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TJP2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TJP2
    OriGene qSTAR qPCR primer pairs in human, mouse for TJP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TJP2
    QuantiTect SYBR Green Assays in human, mouse, rat TJP2
    QuantiFast Probe-based Assays in human, mouse, rat TJP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TJP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TJP2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tjp21 , 5 tight junction protein 21, 5 84.22(n)1
    87.2(a)1
      19 (19.17 cM)5
    218731  NM_001198985.11  NP_001185914.11 
     240945235 
    chicken
    (Gallus gallus)
    Aves TJP21 tight junction protein 2 (zona occludens 2) 73.58(n)
    78.82(a)
      395751  NM_204918.1  NP_990249.1 
    lizard
    (Anolis carolinensis)
    Reptilia TJP26
    tight junction protein 2
    76(a)
    1 ↔ 1
    2(49611370-49666501)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48302 Xenopus laevis transcribed sequence with moderate similarity more 77.09(n)    BJ068509.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tjp2a1 tight junction protein 2a (zona occludens 2) 60.68(n)
    61.72(a)
      565446  NM_001201570.1  NP_001188499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pyd6
    polychaetoid
    15(a)
    1 → many
    3R(4652790-4757599)
    worm
    (Caenorhabditis elegans)
    Secernentea zoo-16
    Protein ZOO-1, isoform a
    24(a)
    1 → many
    I(14529531-14546721) WBGene00013683


    ENSEMBL Gene Tree for TJP2 (if available)
    TreeFam Gene Tree for TJP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TJP2 gene
    DLG52  TJP32  TJP12  
    Selected SIMAP similar genes for TJP2 using alignment to 5 protein entries:     ZO2_HUMAN (see all proteins) (see all similar genes):
    TJP1    DLG4    DLG1    DKFZp686M05161    TJP3    DLG3
    PDZK1P1    PDZK1P2    DLG2    GOPC    LRRC7    PTPN13
    ERBB2IP    IL16    PDZD2    INADL    MPDZ    FRMPD2

    Find genes that share paralogs with TJP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TJP2 (see all 3241)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0160044
    Familial hypercholanemia (FHCA)4--see VAR_0160042 V A mis40--------
    rs101181461,2
    C,F,A,H--71734198(+) GCGCCC/TGCCAC 1 -- us2k15Minor allele frequency- T:0.25NA WA 12
    rs1440643121,2
    C--71734232(+) ATTTTC/TAGTAG 1 -- us2k10--------
    rs1464522261,2
    --71734253(+) TCACCA/GTGGTA 1 -- us2k10--------
    rs1926157871,2
    --71734255(+) ACCATA/GGTAGC 1 -- us2k10--------
    rs1408278951,2
    --71734325(+) GGATTA/CCAGGT 1 -- us2k10--------
    rs107814251,2
    C,F,A,H--71734346(+) AAGCCT/CGGCCC 1 -- us2k17Minor allele frequency- C:0.43NA WA EA 366
    rs773638681,2
    C,F--71734351(+) CGGCCC/TGTTTT 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs123535311,2
    C--71734378(+) acagtG/Ttaagg 1 -- us2k10--------
    rs1449879931,2
    C--71734426(+) TTATG-/ACAGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TJP2 (71736209 - 71870124 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TJP2 (see all 38):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2466554CNV Deletion19546169
    esv2559913CNV Deletion19546169
    nsv821495CNV Deletion20802225
    esv2677043CNV Deletion23128226
    esv2789CNV Deletion18987735
    esv4666CNV Deletion18987735
    esv3271CNV Deletion18987735
    esv2738532CNV Deletion23290073
    esv1026000CNV Deletion17803354
    esv2661677CNV Deletion23128226

    Human Gene Mutation Database (HGMD): TJP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TJP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TJP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607709   
    OMIM disorders: 607748  
    UniProtKB/Swiss-Prot: ZO2_HUMAN, Q9UDY2
  • Familial hypercholanemia (FHCA) [MIM:607748]: A disorder characterized by elevated serum bile acid
    concentrations, itching, and fat malabsorption. Note=The disease may be caused by mutations affecting distinct
    genetic loci, including the gene represented in this entry

  • 7 diseases for TJP2:    
    About MalaCards
    cholestasis, progressive familial intrahepatic 4    deafness, autosomal dominant 51    cholestasis, progressive familial intrahepatic 2    friedreich ataxia
    hypercholanemia, familial    ataxia    deafness, autosomal dominant 4b


    Find genes that share disorders with TJP2           About GenesLikeMe

    5 Novoseek inferred disease relationships for TJP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 13.7 5 10360833 (1), 11018256 (1), 17585317 (1), 10495427 (1)
    breast cancer 0 1 15571953 (1)
    tumors 0 4 7590743 (1), 8132716 (1), 7485497 (1)
    carcinoma 0 1 10495427 (1)
    cancer 0 1 11018256 (1)

    Genetic Association Database (GAD): TJP2

    Export disorders for TJP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TJP2 gene, integrated from 10 sources (see all 164):
    (articles sorted by number of sources associating them with TJP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb. (PubMed id 7951235)1, 2, 3 Duclos F.... Koenig M. (Hum. Mol. Genet. 1994)
    2. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. (PubMed id 12704386)1, 2, 9 Carlton V.E.H.... Bull L.N. (Nat. Genet. 2003)
    3. Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues. (PubMed id 11018256)1, 2, 9 Chlenski A....Scarpelli D.G. (Biochim. Biophys. Acta 2000)
    4. Zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells. (PubMed id 10495427)1, 2, 9 Chlenski A.... Scarpelli D.G. (Int. J. Cancer 1999)
    5. Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma. (PubMed id 10360833)1, 2, 9 Chlenski A.... Scarpelli D.G. (Int. J. Cancer 1999)
    6. Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study. (PubMed id 22044751)1, 4 Foster M.C....Fox C.S. (BMC Med. Genet. 2011)
    7. Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51. (PubMed id 20602916)1, 3 Walsh T....Avraham K.B. (Am. J. Hum. Genet. 2010)
    8. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). (PubMed id 18823282)1, 2 Aho S.... Gruffat H. (Biol. Cell 2009)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells. (PubMed id 15975580)1, 2 Metais J.-Y.... Borg J.-P. (FEBS Lett. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9414 HGNC: 11828 AceView: TJP2 Ensembl:ENSG00000119139 euGenes: HUgn9414
    ECgene: TJP2 Kegg: 9414 H-InvDB: TJP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TJP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TJP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TJP2 gene:
    Search GeneIP for patents involving TJP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TJP2
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TJP2  
     OriGene qPCR primer pairs and template standards for TJP2   OriGene Protein Over-expression Lysate for TJP2  
     OriGene MassSpec for TJP2   OriGene clones in human, mouse for TJP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TJP2   OriGene Purified Protein for TJP2  
     OriGene ORF clones in mouse, rat for TJP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TJP2   OriGene Custom Protein Services for TJP2  

     
     
     Block miRNA regulation of human, mouse, rat TJP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TJP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TJP2 Predesigned siRNA for gene silencing in human, mouse, rat TJP2
     QuantiFast Probe-based Assays in human, mouse, rat TJP2 QuantiTect SYBR Green Assays in human, mouse, rat TJP2
     PCR Arrays including human, mouse, rat TJP2 Search Chromatin IP Primers for TJP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TJP2  GeneGlobe Interaction Network for TJP2
     Regulatory tfbs in TJP2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TJP2 GenScript cDNA clones with any tag delivered in your preferred vector for TJP2
     GenScript Custom Assay Services for TJP2 GenScript Custom overexpressing Cell Line Services for TJP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TJP2  (ZO2)

     Search Tocris compounds for TJP2 (ZO2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TJP2 antibodies
     TJP2 proteins
     TJP2 lysates
     Antibodies for TJP2
     See all of Abcam's Antibodies, Kits and Proteins for TJP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TJP2
     Antibodies for TJP2
     ELISAs for TJP2
     CLIAs for TJP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TJP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TJP2
     SwitchGear 3'UTR luciferase reporter plasmids for TJP2
     SwitchGear Promoter luciferase reporter plasmids for TJP2
     ThermoFisher Antibodies for TJP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TJP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TJP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TJP2
     LSBio Antibodies in human, mouse, rat for TJP2
     Browse compounds at ApexBio
     Addgene plasmids for TJP2
      Search eBioscience for proteins for TJP2
      Search eBioscience for elisas for TJP2
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for TJP2 (61 products)
     antibodies-online kits for TJP2 (7 products)
     antibodies-online peptides for TJP2
     antibodies-online proteins for TJP2 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TJP2 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4