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Aliases for TJAP1 Gene

Aliases for TJAP1 Gene

  • Tight Junction Associated Protein 1 (Peripheral) 2 3
  • TJP4 3 4 6
  • PILT 3 4 6
  • Protein Incorporated Later Into Tight Junctions 3 4
  • Tight Junction Protein 4 (Peripheral) 2 3
  • Tight Junction-Associated Protein 1 3
  • Tight Junction Protein 4 4

External Ids for TJAP1 Gene

Previous HGNC Symbols for TJAP1 Gene

  • TJP4

Previous GeneCards Identifiers for TJAP1 Gene

  • GC06P043554
  • GC06P043445
  • GC06P043163

Summaries for TJAP1 Gene

Entrez Gene Summary for TJAP1 Gene

  • This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]

GeneCards Summary for TJAP1 Gene

TJAP1 (Tight Junction Associated Protein 1 (Peripheral)) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Sertoli-Sertoli Cell Junction Dynamics. An important paralog of this gene is BEGAIN.

Gene Wiki entry for TJAP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TJAP1 Gene

Genomics for TJAP1 Gene

Regulatory Elements for TJAP1 Gene

Genomic Location for TJAP1 Gene

Start:
43,477,523 bp from pter
End:
43,506,556 bp from pter
Size:
29,034 bases
Orientation:
Plus strand

Genomic View for TJAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TJAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TJAP1 Gene

Proteins for TJAP1 Gene

  • Protein details for TJAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTD0-TJAP1_HUMAN
    Recommended name:
    Tight junction-associated protein 1
    Protein Accession:
    Q5JTD0
    Secondary Accessions:
    • Q05BH9
    • Q5JTD1
    • Q5JWW1
    • Q68DB2
    • Q6P2P3
    • Q9H7V7

    Protein attributes for TJAP1 Gene

    Size:
    557 amino acids
    Molecular mass:
    61821 Da
    Quaternary structure:
    • Interacts with DLG1.

    Alternative splice isoforms for TJAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TJAP1 Gene

Proteomics data for TJAP1 Gene at MOPED

Post-translational modifications for TJAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TJAP1 Gene

Domains for TJAP1 Gene

Protein Domains for TJAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TJAP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TJAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TJAP1 Gene

Function for TJAP1 Gene

Gene Ontology (GO) - Molecular Function for TJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15263016
genes like me logo Genes that share ontologies with TJAP1: view

Animal Model Products

CRISPR Products

miRNA for TJAP1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TJAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TJAP1 Gene

Localization for TJAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TJAP1 Gene

Golgi apparatus. Cell junction, tight junction. Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TJAP1 Gene COMPARTMENTS Subcellular localization image for TJAP1 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TJAP1: view

Pathways for TJAP1 Gene

genes like me logo Genes that share pathways with TJAP1: view

Pathways by source for TJAP1 Gene

1 KEGG pathway for TJAP1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IEA --
genes like me logo Genes that share ontologies with TJAP1: view

Transcripts for TJAP1 Gene

Unigene Clusters for TJAP1 Gene

Tight junction associated protein 1 (peripheral):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TJAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TJAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - - - - - - -
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SP14:
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SP33: - - - - - - - - - - - - - -
SP34: - - - - - - - - - - - - - -
SP35: - - - - - -
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SP40: - - - - - - - - - -
SP41: - - - - - - -
SP42: - - - - - - - - - - - - - - - - -
SP43: - - -
SP44:

ExUns: 10d · 10e · 10f · 10g ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
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SP10:
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SP20: - - - -
SP21:
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SP41:
SP42:
SP43:
SP44:

Relevant External Links for TJAP1 Gene

GeneLoc Exon Structure for
TJAP1
ECgene alternative splicing isoforms for
TJAP1

Expression for TJAP1 Gene

mRNA expression in normal human tissues for TJAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TJAP1 Gene

SOURCE GeneReport for Unigene cluster for TJAP1 Gene Hs.520145

mRNA Expression by UniProt/SwissProt for TJAP1 Gene

Q5JTD0-TJAP1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with TJAP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TJAP1 Gene

Orthologs for TJAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TJAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TJAP1 35
  • 99.46 (n)
  • 99.46 (a)
TJAP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TJAP1 35
  • 88.03 (n)
  • 91.39 (a)
TJAP1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TJAP1 35
  • 88.55 (n)
  • 90.78 (a)
TJAP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tjap1 35
  • 82.99 (n)
  • 87.24 (a)
Tjap1 16
Tjap1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TJAP1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TJAP1 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tjap1 35
  • 84.73 (n)
  • 87.9 (a)
chicken
(Gallus gallus)
Aves TJAP1 35
  • 67.52 (n)
  • 68.67 (a)
TJAP1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TJAP1 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC566060 35
  • 64.95 (n)
  • 65.81 (a)
tjap1 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42324 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for TJAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TJAP1 Gene

ENSEMBL:
Gene Tree for TJAP1 (if available)
TreeFam:
Gene Tree for TJAP1 (if available)

Paralogs for TJAP1 Gene

Paralogs for TJAP1 Gene

Selected SIMAP similar genes for TJAP1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TJAP1 Gene

genes like me logo Genes that share paralogs with TJAP1: view

Variants for TJAP1 Gene

Sequence variations from dbSNP and Humsavar for TJAP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs831317 -- 43,475,894(-) CATCC(C/T)AGGAA upstream-variant-2KB
rs885039 -- 43,494,649(-) aaaaa(A/G)ggaaa intron-variant
rs1150798 -- 43,481,083(-) CCATC(C/T)TGACA intron-variant
rs1150799 -- 43,486,231(-) tccct(A/G)cactt intron-variant
rs1214836 -- 43,501,548(-) AAGCT(C/T)TTCAT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TJAP1 Gene

Variant ID Type Subtype PubMed ID
dgv6841n71 CNV Loss 21882294
esv2731999 CNV Deletion 23290073

Relevant External Links for TJAP1 Gene

HapMap Linkage Disequilibrium report
TJAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TJAP1 Gene

Disorders for TJAP1 Gene

No disorders were found for TJAP1 Gene.

No data available for UniProtKB/Swiss-Prot for TJAP1 Gene

Publications for TJAP1 Gene

  1. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. (PMID: 11602598) Kawabe H. … Takai Y. (J. Biol. Chem. 2001) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TJAP1 Gene

Sources for TJAP1 Gene

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