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Aliases for TJAP1 Gene

Aliases for TJAP1 Gene

  • Tight Junction Associated Protein 1 2 3
  • Tight Junction Associated Protein 1 (Peripheral) 2 3 5
  • Protein Incorporated Later Into Tight Junctions 3 4
  • Tight Junction Protein 4 (Peripheral) 2 3
  • TJP4 3 4
  • PILT 3 4
  • Tight Junction Protein 4 4

External Ids for TJAP1 Gene

Previous HGNC Symbols for TJAP1 Gene

  • TJP4

Previous GeneCards Identifiers for TJAP1 Gene

  • GC06P043554
  • GC06P043445
  • GC06P043163

Summaries for TJAP1 Gene

Entrez Gene Summary for TJAP1 Gene

  • This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]

GeneCards Summary for TJAP1 Gene

TJAP1 (Tight Junction Associated Protein 1) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Tight junction. An important paralog of this gene is BEGAIN.

Gene Wiki entry for TJAP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TJAP1 Gene

Genomics for TJAP1 Gene

Regulatory Elements for TJAP1 Gene

Promoters for TJAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TJAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TJAP1 Gene

Chromosome:
6
Start:
43,477,523 bp from pter
End:
43,506,556 bp from pter
Size:
29,034 bases
Orientation:
Plus strand

Genomic View for TJAP1 Gene

Genes around TJAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TJAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TJAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TJAP1 Gene

Proteins for TJAP1 Gene

  • Protein details for TJAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTD0-TJAP1_HUMAN
    Recommended name:
    Tight junction-associated protein 1
    Protein Accession:
    Q5JTD0
    Secondary Accessions:
    • Q05BH9
    • Q5JTD1
    • Q5JWW1
    • Q68DB2
    • Q6P2P3
    • Q9H7V7

    Protein attributes for TJAP1 Gene

    Size:
    557 amino acids
    Molecular mass:
    61821 Da
    Quaternary structure:
    • Interacts with DLG1.

    Alternative splice isoforms for TJAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TJAP1 Gene

Proteomics data for TJAP1 Gene at MOPED

Post-translational modifications for TJAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TJAP1 Gene

Domains & Families for TJAP1 Gene

Protein Domains for TJAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TJAP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TJAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TJAP1 Gene

Function for TJAP1 Gene

genes like me logo Genes that share phenotypes with TJAP1: view

Animal Model Products

CRISPR Products

miRNA for TJAP1 Gene

miRTarBase miRNAs that target TJAP1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TJAP1 Gene

Localization for TJAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TJAP1 Gene

Golgi apparatus. Cell junction, tight junction. Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TJAP1 Gene COMPARTMENTS Subcellular localization image for TJAP1 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 2
endosome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TJAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with TJAP1: view

Pathways & Interactions for TJAP1 Gene

genes like me logo Genes that share pathways with TJAP1: view

Pathways by source for TJAP1 Gene

1 KEGG pathway for TJAP1 Gene

Gene Ontology (GO) - Biological Process for TJAP1 Gene

None

No data available for SIGNOR curated interactions for TJAP1 Gene

Drugs & Compounds for TJAP1 Gene

No Compound Related Data Available

Transcripts for TJAP1 Gene

Unigene Clusters for TJAP1 Gene

Tight junction associated protein 1 (peripheral):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TJAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
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SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - -
SP14:
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - - - - - -
SP21: - - - - - - - -
SP22: - - - - - - - -
SP23: - - - - - -
SP24: - - - - -
SP25: - - - - - -
SP26: - - - - - - - - - - - - -
SP27: - - - - - - - - - - - - - -
SP28: - - - - - - - - - - - - -
SP29: - - - - - - - - - - - - - - - -
SP30: - - - - - - - - - - - - -
SP31: - - - - - - - - - - - - - - -
SP32: - - - - - - - - - - - - - - -
SP33: - - - - - - - - - - - - - -
SP34: - - - - - - - - - - - - - -
SP35: - - - - - -
SP36: - - - - - -
SP37: - - - - -
SP38: - - - - - - -
SP39: - - - - - - - - - - - - - - - -
SP40: - - - - - - - - - -
SP41: - - - - - - -
SP42: - - - - - - - - - - - - - - - - -
SP43: - - -
SP44:

ExUns: 10d · 10e · 10f · 10g ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10:
SP11: - - - - - -
SP12: - - - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - - -
SP16: - - - - -
SP17:
SP18:
SP19:
SP20: - - - -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:
SP37:
SP38:
SP39:
SP40:
SP41:
SP42:
SP43:
SP44:

Relevant External Links for TJAP1 Gene

GeneLoc Exon Structure for
TJAP1
ECgene alternative splicing isoforms for
TJAP1

Expression for TJAP1 Gene

mRNA expression in normal human tissues for TJAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TJAP1 Gene

This gene is overexpressed in Adrenal (29.3) and Peripheral blood mononuclear cells (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TJAP1 Gene



SOURCE GeneReport for Unigene cluster for TJAP1 Gene Hs.520145

mRNA Expression by UniProt/SwissProt for TJAP1 Gene

Q5JTD0-TJAP1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with TJAP1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TJAP1 Gene

Orthologs for TJAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TJAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TJAP1 35
  • 88.03 (n)
  • 91.39 (a)
TJAP1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TJAP1 35
  • 88.55 (n)
  • 90.78 (a)
TJAP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tjap1 35
  • 82.99 (n)
  • 87.24 (a)
Tjap1 16
Tjap1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TJAP1 35
  • 99.46 (n)
  • 99.46 (a)
TJAP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tjap1 35
  • 84.73 (n)
  • 87.9 (a)
oppossum
(Monodelphis domestica)
Mammalia TJAP1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TJAP1 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TJAP1 35
  • 67.52 (n)
  • 68.67 (a)
TJAP1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TJAP1 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC566060 35
  • 64.95 (n)
  • 65.81 (a)
tjap1 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42324 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for TJAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TJAP1 Gene

ENSEMBL:
Gene Tree for TJAP1 (if available)
TreeFam:
Gene Tree for TJAP1 (if available)

Paralogs for TJAP1 Gene

Paralogs for TJAP1 Gene

(1) SIMAP similar genes for TJAP1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TJAP1 Gene

genes like me logo Genes that share paralogs with TJAP1: view

Variants for TJAP1 Gene

Sequence variations from dbSNP and Humsavar for TJAP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs831317 -- 43,475,894(-) CATCC(C/T)AGGAA upstream-variant-2KB
rs885039 -- 43,494,649(-) aaaaa(A/G)ggaaa intron-variant
rs1150798 -- 43,481,083(-) CCATC(C/T)TGACA intron-variant
rs1150799 -- 43,486,231(-) tccct(A/G)cactt intron-variant
rs1214836 -- 43,501,548(-) AAGCT(C/T)TTCAT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TJAP1 Gene

Variant ID Type Subtype PubMed ID
dgv6841n71 CNV Loss 21882294
esv2731999 CNV Deletion 23290073

Variation tolerance for TJAP1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TJAP1 Gene

HapMap Linkage Disequilibrium report
TJAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TJAP1 Gene

Disorders for TJAP1 Gene

Relevant External Links for TJAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TJAP1

No disorders were found for TJAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TJAP1 Gene

Publications for TJAP1 Gene

  1. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. (PMID: 11602598) Kawabe H. … Takai Y. (J. Biol. Chem. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TJAP1 Gene

Sources for TJAP1 Gene

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