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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TJAP1 Gene

protein-coding   GIFtS: 51
GCID: GC06P043445

Tight Junction Associated Protein 1 (Peripheral)

(Previous name: tight junction protein 4 (peripheral))
(Previous symbol: TJP4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tight Junction Associated Protein 1 (Peripheral)1 2     Protein Incorporated Later Into Tight Junctions2 3
TJP41 2 3 5     Tight Junction-Associated Protein 12
PILT2 3 5     Tight Junction Protein 43
Tight Junction Protein 4 (Peripheral)1 2     

External Ids:    HGNC: 179491   Entrez Gene: 936432   Ensembl: ENSG000001372217   OMIM: 6126585   UniProtKB: Q5JTD03   
ORGUL members:         
NONCODE14:n341853 n407841      

Export aliases for TJAP1 gene to outside databases

Previous GC identifers: GC06P043554 GC06P043163


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TJAP1 Gene:
This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions
occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function
in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene
exists on the X chromosome. (provided by RefSeq, Mar 2009)

GeneCards Summary for TJAP1 Gene: 
TJAP1 (tight junction associated protein 1 (peripheral)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TJAP1 include gonorrhea. GO annotations related to this gene include protein binding. An important paralog of this gene is BEGAIN.

Gene Wiki entry for TJAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TJAP1 gene promoter:
         STAT5B   AhR   Pax-5   NF-E2 p45   Cdc5   Arnt   Ik-2   E2F-1   E2F   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTJAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TJAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TJAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TJAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TJAP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043445:  view genomic region     (about GC identifiers)

Start:
43,445,261 bp from pter      End:
43,474,294 bp from pter
Size:
29,034 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TJAP1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TJAP1_HUMAN, Q5JTD0 (See protein sequence)
Recommended Name: Tight junction-associated protein 1  
Size: 557 amino acids; 61821 Da
Subunit: Interacts with DLG1
Subcellular location: Golgi apparatus (By similarity). Cell junction, tight junction (By similarity).
Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from
adherens junctions and desmosomes (By similarity)
Secondary accessions: Q05BH9 Q5JTD1 Q5JWW1 Q68DB2 Q6P2P3 Q9H7V7
Alternative splicing: 4 isoforms:  Q5JTD0-1   Q5JTD0-2   Q5JTD0-3   Q5JTD0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TJAP1: NX_Q5JTD0

Explore proteomics data for TJAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JTD0

  • TJAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TJAP1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001139488.1  NP_001139489.1  NP_001139490.1  NP_001139491.1  NP_001139492.1  NP_542171.2  

    ENSEMBL proteins: 
     ENSP00000361532   ENSP00000390981   ENSP00000259751   ENSP00000361530   ENSP00000361527  
     ENSP00000391115   ENSP00000361521   ENSP00000361522   ENSP00000407080   ENSP00000408769  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005923tight junction IEA--

    TJAP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5JTD0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15263016
         
    TJAP1 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TJAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for TJAP1):
        Tight junction


    TJAP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TJAP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for TJAP1 (Q5JTD03 ENSP000002597514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129593, ENSP000003457314I2D: score=2 STRING: ENSP00000345731
    DLG3Q927963I2D: score=1 
    YWHABP319463I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TJAP1

    Search CenterWatch for drugs/clinical trials and news about TJAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for TJAP1 gene (6 alternative transcripts): 
    NM_001146016.1  NM_001146017.1  NM_001146018.1  NM_001146019.1  NM_001146020.1  NM_080604.2  

    Unigene Cluster for TJAP1:

    Tight junction associated protein 1 (peripheral)
    Hs.520145  [show with all ESTs]
    Unigene Representative Sequence: AK123398
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372454 ENST00000442878 ENST00000259751 ENST00000372452 ENST00000372449
    ENST00000483640(uc003ovg.2 uc010jyq.2 uc003ovi.2) ENST00000478173
    ENST00000459851 ENST00000490050 ENST00000454762(uc011dvj.2) ENST00000372444(uc003ovf.2)
    ENST00000372445(uc003ovd.2 uc003ove.2 uc003ovc.2 uc010jyp.2)
    ENST00000436109(uc011dvh.1) ENST00000438588(uc011dvi.1)
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    Inhib. RNA
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    Additional mRNA sequence: 

    AJ420477.1 AK024269.1 AK074241.1 AK123398.1 AK225787.1 AK307483.1 AK308866.1 AK309119.1 
    AL117398.1 BC046239.1 BC064401.1 NR_027394.1 

    24/27 DOTS entries (see all 27):

    DT.95157582  DT.40195916  DT.100784118  DT.100762516  DT.410288  DT.121405387  DT.97781694  DT.102842119 
    DT.100026815  DT.91921907  DT.100784116  DT.121405459  DT.97814781  DT.121405344  DT.100026813  DT.121405484 
    DT.121405712  DT.121405779  DT.439510  DT.121405467  DT.121405478  DT.121405705  DT.121405817  DT.100762065 

    24/125 AceView cDNA sequences (see all 125):

    BC046239 BM142185 AA643153 BX396744 AI632823 BQ063324 AA335416 BG913044 
    AK094907 AI566712 BC064401 BF982521 AK024269 BM992035 AI000537 AK127338 
    AK074241 CK819946 AI699828 AL117398 NM_080604 BU621644 BQ882934 BX399187 

    GeneLoc Exon Structure

    5/44 Alternative Splicing Database (ASD) splice patterns (SP) for TJAP1 (see all 44)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c ·
    SP1:              -                       -     -     -     -     -     -     -     -                                   -     -     -     -           -     -   
    SP2:                                            -     -     -     -     -     -     -           -                       -     -     -     -           -     -   
    SP3:              -                       -     -     -     -     -     -     -     -           -                       -     -     -     -           -     -   
    SP4:                                                                                -           -                       -     -     -     -           -     -   
    SP5:              -     -     -           -     -     -     -     -     -     -     -           -                       -     -     -     -           -     -   

    ExUns: 10d · 10e · 10f · 10g ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:  -     -     -     -           -                 -     -     -     -                             -                           
    SP2:  -     -     -     -           -                 -     -     -     -                             -                           
    SP3:  -     -     -     -           -                 -     -     -     -                             -                           
    SP4:  -     -     -     -           -                 -                                               -                           
    SP5:  -     -     -     -           -                 -     -     -     -                                                         


    ECgene alternative splicing isoforms for TJAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TJAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTGTTGCC
    TJAP1 Expression
    About this image


    See TJAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TJAP1

    SOURCE GeneReport for Unigene cluster: Hs.520145

    UniProtKB/Swiss-Prot: TJAP1_HUMAN, Q5JTD0
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including TJAP1: 
              Tight Junctions in human mouse rat
              Gap Junctions in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TJAP1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tjap11 , 5 tight junction associated protein 11, 5 83.99(n)1
    88.56(a)1
      17 (22.90 cM)5
    740941  NM_001252473.11  NP_001239402.11 
     462578515 
    chicken
    (Gallus gallus)
    Aves TJAP11 tight junction associated protein 1 (peripheral) 67.29(n)
    68.83(a)
      421455  XM_419505.3  XP_419505.3 
    lizard
    (Anolis carolinensis)
    Reptilia TJAP16
    tight junction associated protein 1 (peripheral)
    57(a)
    1 ↔ 1
    1(231075398-231102847)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD302828.12   -- 82.14(n)    CD302828.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5660601 tight junction-associated protein 1-like 62.05(n)
    61.18(a)
      566060  XM_001921650.3  XP_001921685.3 


    ENSEMBL Gene Tree for TJAP1 (if available)
    TreeFam Gene Tree for TJAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TJAP1 gene
    BEGAIN2  
    1 SIMAP similar gene for TJAP1 using alignment to 4 protein entries:     TJAP1_HUMAN (see all proteins):
    BEGAIN

    TJAP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TJAP1
    PGOHUM00000241539


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/657 SNPs in TJAP1 are shown (see all 657)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844314851,2
    --43443277(+) TGTGTA/GTGCGT 6 -- us2k10--------
    rs94720621,2
    C,F,H--43443333(+) CAGCTC/GCATCT 6 -- us2k14Minor allele frequency- G:0.03NS EA 416
    rs1868724071,2
    --43443371(+) CTGCTC/TTGAAA 6 -- us2k10--------
    rs1916046611,2
    --43443378(+) GAAATA/GTTGAT 6 -- us2k10--------
    rs734267121,2
    C--43443424(+) GAATTG/CCTGGA 6 -- us2k11Minor allele frequency- C:0.50WA 2
    rs734267131,2
    C--43443445(+) GGCTGC/TCACCA 6 -- us2k10--------
    rs1840872671,2
    --43443561(+) AGGTCC/TGAGGA 6 -- us2k10--------
    rs8313171,2
    C,F,H--43443632(-) CATCCT/CAGGAA 6 -- us2k1 tfbs310Minor allele frequency- C:0.10NS NA EA WA 1066
    rs1492548801,2
    --43443717(+) GCTTGC/TCTTTG 6 -- us2k10--------
    rs1158731711,2
    F--43443899(+) CAGTGG/TCTCAC 6 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TJAP1 (43445261 - 43474294 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TJAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731999CNV Deletion23290073
    dgv6841n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612658    OMIM disorders: --

    2 diseases for TJAP1:    About MalaCards
    gonorrhea    


    TJAP1 for disorders           About GeneDecksing


    Export disorders for TJAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TJAP1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TJAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. (PubMed id 11602598)1, 2, 3 Kawabe H.... Takai Y. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93643 HGNC: 17949 AceView: TJP4 Ensembl:ENSG00000137221 euGenes: HUgn93643
    ECgene: TJAP1 Kegg: 93643 H-InvDB: TJAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TJAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TJAP1 gene:
    Search GeneIP for patents involving TJAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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