Aliases for TIRAP Gene
External Ids for TIRAP Gene
Previous GeneCards Identifiers for TIRAP Gene
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIRAP Gene
TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with TIRAP include Bacteremia, Protection Against and Invasive Pneumococcal Disease, Recurrent Isolated, 1. Among its related pathways are MyD88 cascade initiated on plasma membrane and Diseases associated with the TLR signaling cascade. GO annotations related to this gene include protein homodimerization activity and protein binding, bridging.
UniProtKB/Swiss-Prot for TIRAP Gene
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.