V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

TIRAP Gene

protein-coding GIFtS: 59

GC11P125658

toll-interleukin 1 receptor (TIR) domain containing adaptor protein
(Previous name: Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ42305 ^²
MAL ^³
Mal ^¹, ²
OTTHUMP00000179130 ^²
OTTHUMP00000179132 ^²
wyatt ^¹, ²

Descriptions
Adaptor protein Wyatt ^³
MyD88 adapter-like protein ^², ³
TIR domain-containing adapter protein ^³
Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein ^¹
Toll-interleukin 1 receptor domain-containing adaptor protein ^²
Toll-like receptor adaptor protein ^²
adapter protein wyatt ^²
toll-interleukin 1 receptor (TIR) domain containing adaptor protein ^²
toll-interleukin 1 receptor domain containing adaptor protein ^¹

External Ids
HGNC: 17192¹
Entrez Gene: 114609²
UniProtKB: P58753³
Ensembl: ENSG00000150455⁷

Search outside databases for aliases for TIRAP gene

Previous GC identifers: GC11P128153 GC11P127665 GC11P126186 GC11P125690

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TIRAP:

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which

identify pathogen-associated molecular patterns. Different TLRs recognize different

pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR)

domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR

adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates

NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory

response. Alternative splicing of this gene results in several transcript variants; however, not

all variants have been fully described. [provided by RefSeq]

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753

Function: Adapter involved in the TLR4 signaling pathway in the innate immune response. Acts via

IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in

cytokine secretion and the inflammatory response

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TIRAP gene

Entrez Gene cytogenetic band: 11q24.2 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24.2

TIRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P125658: (about GC identifiers)

Start:	125,658,192 bp from pter
End:	125,670,038 bp from pter
Size:	11,847 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753 (See protein sequence)

Recommended Name: Toll/interleukin-1 receptor domain-containing adapter protein

Size: 221 amino acids; 23883 Da

Subunit: Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their

respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: B3KW65 Q56UI0 Q8N5E5

Alternative splicing: 3 isoforms: P58753-1 P58753-2 P58753-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001034750.1 NP_683708.1

ENSEMBL proteins:

ENSP00000279992 ENSP00000376447 ENSP00000376446 ENSP00000376445

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TIRAP)
	Human Recombinant Proteins from Abnova (TIRAP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	EXP	12447442 14625308 16024789
GO:0031224	intrinsic to membrane	IEA	--

About this table

Antibodies for TIRAP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TIRAP
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TIRAP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for TIRAP

Assays for TIRAP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P58753

ProtoNet protein and cluster: P58753

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753

Similarity: Contains 1 TIR domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TIRAP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TIRAP)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001039661

Applied Biosystems Silencer® siRNAs for TIRAP

Sigma-Aldrich siRNA and siRNA Panels for TIRAP

Sigma-Aldrich shRNA for TIRAP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TIRAP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001039661
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001039661
untagged cDNA clones in CMV expression vector (see all 2): NM_001039661

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_148910

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753

Function: Adapter involved in the TLR4 signaling pathway in the innate immune response. Acts via

IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in

cytokine secretion and the inflammatory response

3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tirap):

hematopoietic system

immune system

life span-post-weaning/aging

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	IEA	--
GO:0005515	protein binding	IPI	11544529 12721283

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for TIRAP (Your Favorite Gene powered by Ingenuity)

Toll-like Receptor Signaling
Hepatic Cholestasis
NF-&kappa

GeneDecks TIRAP for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TIRAP

5/47 Interacting proteins for TIRAP (P58753^{1, 2} ENSP00000279992³) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TLR4	O00206¹, ENSP00000363089³	EBI-528644, EBI-528701 STRING (score=.999)
IRAK2	O43187¹, ENSP00000256458³	EBI-528644, EBI-447733 STRING (score=.949)
MYD88	Q99836¹^,²	EBI-528644, EBI-447677 MINT-4950432 MINT-4950481 EBI-528644, EBI-447677 MINT-4950432 MINT-4950481
TICAM2	Q86XR7¹	EBI-528644, EBI-525927
MYD88	Q99836¹^,²	EBI-528644, EBI-447677 MINT-4950432 MINT-4950481 EBI-528644, EBI-447677 MINT-4950432 MINT-4950481

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007249	I-kappaB kinase/NF-kappaB cascade	EXP	15276183
GO:0045087	innate immune response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TIRAP
1 Novoseek chemical compound relationship for TIRAP gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	5.66	18	18070880 (7), 16439361 (5), 18292575 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TIRAP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TIRAP)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001039661

Sigma-Aldrich siRNA and siRNA Panels for TIRAP

Sigma-Aldrich shRNA for TIRAP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001039661 NM_148910

REFSEQ mRNAs for TIRAP gene (2 alternative transcripts):

NM_001039661.1 NM_148910.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001039661 NM_148910

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001039661
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001039661
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001039661

Additional cDNA sequence:

AB446477.1 AF378129.1 AF406652.1 AK124298.1 AK313147.1 AY576785.1 AY576786.1 AY576787.1

BC032474.1

6 DOTS entries:

DT.100754334 DT.92012742 DT.95096907 DT.100754331 DT.408184 DT.91748566

24/65 AceView cDNA sequences (see all 65 ):

BU163392 BQ877571 NM_052887 AA322884 AA135034 BU150555 BM762171 BX283452

AA346928 NM_148910 BM762042 AF410783 BQ686094 BQ687079 BM762452 CK430181

BQ651057 BQ647099 BQ651026 AF406652 AA384704 AA242959 BQ649886 BQ645814

highest scoring ESTs for TIRAP:

AA135034 BC032474 BF960163 BF960384 BI252480 BQ019169 BQ220785 BQ422626 BQ645814 BQ645991

Unigene Cluster for TIRAP:

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein

Hs.537126 [show with all ESTs]

Unigene Representative Sequence: NM_001039661

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TIRAP (see all 11 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c
SP1:									-														-		-		-		-										-
SP2:									-						-								-		-		-		-										-
SP3:									-														-				-		-		-
SP4:									-		-		-		-								-		-		-		-										-
SP5:									-														-		-		-		-

About this scheme

ECgene alternative splicing isoforms for TIRAP

4 Ensembl transcripts including schematic representations:

ENST00000279992 ENST00000392680 ENST00000392679 ENST00000392678

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TIRAP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TIRAP

¹ / ² / ³

8 probe-sets matching TIRAP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62656_r_at²^{, 3}	U95-C	1	1.00	1.00	0.86	0.78	AA621991	0.40	1.00	0.76	1
48297_at²^{, 3}	U95-B	1	1.00	1.00	0.70	0.81	AA135034	0.80	1.00	0.91	1
62622_at²^{, 3}	U95-C	1	0.94	1.00	0.81	1.44	R95888	0.40	1.00	0.76	1
239796_x_at²^{, 3}	U133-B	13	0.91	0.81	--	--	AA284071	0.40	1.00	0.76	1
1554091_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552804_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552360_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239796_x_at²	U133Plus2	12	0.91	0.81	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.537126
UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
Tissue specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also
detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TIRAP gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TIRAP¹	--	toll-interleukin 1 receptor (TIR) domain containing more	83.71(n) 81.45(a)	609544 XM_846817.1 XP_851910.1
chimpanzee (Pan troglodytes)	TIRAP¹	--	toll-interleukin 1 receptor (TIR) domain containing more	99.38(n) 100(a)	451654 XM_508853.2 XP_508853.2
cow (Bos taurus)	TIRAP¹	--	toll-interleukin 1 receptor (TIR) domain containing more	82.27(n) 80(a)	531079 NM_001039962.1 NP_001035051.1
rat (Rattus norvegicus)	Tirap¹	--	toll-interleukin 1 receptor (TIR) domain-containing more	80.24(n) 78.73(a)	680127 XM_001055833.1 XP_001055833.1
mouse (Mus musculus)	Tirap^{1, 5}	9⁵	toll-interleukin 1 receptor (TIR) domain-containing more^{1, 5}	79.79(n)¹ 79.64(a)¹	117149¹ NM_054096.1¹ NP_473437.1¹ AA288979⁵ AA407980⁵ (see all 18)

About this table Species with no ortholog for TIRAP

ENSEMBL Gene Tree for TIRAP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753

Polymorphism: Genetic variation in TIRAP can influence susceptibility or resistance to invasive

pneumococcal disease, bacteremia, malaria and tuberculosi

10/119 NCBI SNPs in TIRAP are shown (see all 119 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10893493^1,2	A,C,F,H	125657857(+)	`TAGGAA/GGATTA`	2	--	ng5¹		4	EU EA WA	418
	rs4937114^1,2	A,C,F,H	125657826(+)	`aaaagG/Ttatga`	2	--	ng5¹ trp³		4	EU EA WA	418
--	rs8177399^1,2	C,F,H	125666036(+)	`GCTCTC/TGGCCT`	2	R/W	mis¹ ese³		6	NS EU EA WA	496
	rs563011^1,2	C,F,H	125656632(-)	`TTTAGC/AGTAAA`	2	--	ng5¹		5	EU EA NS	394
	rs1786697^1,2	A,C,F	125656457(+)	`TCCCCC/GCTGAG`	2	--	ng5¹ trp³		2	NS	94
	rs3802813^1,2	C,F,H	125667678(+)	`GGACAG/ACCCAC`	2	N/S	mis¹ ese³		8	EU EA WA	836
	rs625413^1,2	C,F,H	125669559(+)	`TTCAAC/TGCCTT`	1	--	ut3¹		16	NS MN NA EU EA WA	1464
	rs8177376^1,2	C,F,H	125668822(+)	`GAAATT/GGGAGT`	1	--	ut3¹		9	NS NA EU EA WA	628
--	rs93957^1,2	A,C,F	125656283(-)	`cctccG/Acctcc`	2	--	ng5¹		2	NS	94
--	rs904546^1,2	C,F,H	125656755(-)	`AAGGCC/TCATTT`	2	--	ng5¹		7	EA NA NS EU	428

About this table

HapMap Linkage Disequilibrium images for TIRAP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606252

2 Novoseek disease relationships for TIRAP gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	28.24	1	18070880 (1)
tumors	1.43	1	18070880 (1)

About this table

Human Gene Mutation Database: TIRAP
Genetic Association Database: TIRAP
Human Genome Epidemiology Navigator: TIRAP (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/72 PubMed articles for TIRAP gene (see all 72 ):

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PubMed id 11544529)^{1, 2, 3, 4} Fitzgerald K.A....O'Neill L.A. (2001)
TIRAP: an adapter molecule in the Toll signaling pathway. (PubMed id 11526399)^{2, 3, 4} Horng T.... Medzhitov R. (2001)
The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk. (PubMed id 16284379)^{1, 3, 6} Xu J....Gronberg H. (2005)
Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)^{3, 4} Nakajima T....Kimura A. (2008)
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. (PubMed id 17322885)^{3, 4} Khor C.C....Hill A.V.S. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. (PubMed id 14530355)^{3, 4} Sato S....Akira S. (2003)
Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. (PubMed id 18070880)^{1, 3} Piao W....Medvedev A.E. (2008)
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. (PubMed id 16439361)^{1, 3} Gray P....O'Neill L.A. (2006)
TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. (PubMed id 18417424)^{1, 3} Castiblanco J....Anaya J.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 114609	HGNC: 17192	AceView: TIRAP	Ensembl:ENSG00000150455	euGenes: HUgn114609
ECgene: TIRAP	H-InvDB: TIRAP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/tirap/

Licensable Technologies for TIRAP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TIRAP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TIRAP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TIRAP		Antibodies for TIRAP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TIRAP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TIRAP)
	Search for Antibodies
	Chimera RNAi (TIRAP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TIRAP)
	Antibodies (TIRAP)

Search OriGene for TIRAP

Search Tocris compounds for TIRAP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TIRAP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TIRAP Gene at Home site.
Version 2.41.1
server5.xennexinc.com

TIRAP Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for TIRAP

Summaries
for TIRAP

Genomic Location
for TIRAP

Proteins
for TIRAP

Protein Domains/
Families
for TIRAP

Gene Function
for TIRAP

Pathways & Interactions
for TIRAP

Drugs & Compounds
for TIRAP

Transcripts
for TIRAP

Expression
for TIRAP

Orthologs
for TIRAP

Paralogs
for TIRAP

SNPs/Variants
for TIRAP

Disorders & Mutations
for TIRAP

Medical News
for TIRAP

Publications
for TIRAP

Search for TIRAP

Genome Databases showing TIRAP

Other Databases showing TIRAP

Specialized Databases showing TIRAP

Licensable Technologies
for TIRAP

Services
for TIRAP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TIRAP Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor TIRAP

Summariesfor TIRAP

Genomic Locationfor TIRAP

Proteinsfor TIRAP

Protein Domains/Familiesfor TIRAP

Gene Functionfor TIRAP

Pathways & Interactionsfor TIRAP

Drugs & Compoundsfor TIRAP

Transcriptsfor TIRAP

Expression for TIRAP

Orthologsfor TIRAP

Paralogsfor TIRAP

SNPs/Variantsfor TIRAP

Disorders & Mutationsfor TIRAP

Medical Newsfor TIRAP

Publicationsfor TIRAP

Search for TIRAP

Genome Databases showing TIRAP

Other Databases showing TIRAP

Specialized Databases showing TIRAP

Licensable Technologiesfor TIRAP

Servicesfor TIRAP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TIRAP

Summaries
for TIRAP

Genomic Location
for TIRAP

Proteins
for TIRAP

Protein Domains/
Families
for TIRAP

Gene Function
for TIRAP

Pathways & Interactions
for TIRAP

Drugs & Compounds
for TIRAP

Transcripts
for TIRAP

Expression
for TIRAP

Orthologs
for TIRAP

Paralogs
for TIRAP

SNPs/Variants
for TIRAP

Disorders & Mutations
for TIRAP

Medical News
for TIRAP

Publications
for TIRAP

Licensable Technologies
for TIRAP

Services
for TIRAP