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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIRAP Gene

protein-coding   GIFtS: 61
GCID: GC11P126153

toll-interleukin 1 receptor (TIR) domain containing adaptor...

(Previous name: Toll-interleukin 1 receptor (TIR) domain-containing adaptor...)
 Explore 37 diseases affiliated with
TIRAP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TIRAP    

Aliases
for TIRAP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein1 2     BACTS12
Mal1 2     Adapter Protein Wyatt2
Wyatt1     Toll-Like Receptor Adaptor Protein2
Adaptor Protein Wyatt2 3     Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein2
MyD88-22 3     MAL3
MyD88 Adapter-Like Protein2 3     TIR Domain-Containing Adapter Protein3
Toll-Interleukin 1 Receptor (TIR) Domain-Containing Adaptor Protein1     

External Ids:    HGNC: 171921   Entrez Gene: 1146092   Ensembl: ENSG000001504557   OMIM: 6062525   UniProtKB: P587533   

Export aliases for TIRAP gene to outside databases

Previous GC identifers: GC11P128153 GC11P127665 GC11P126186 GC11P125690 GC11P125658 GC11P122098


Summaries
for TIRAP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TIRAP:
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify
pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and
all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein
encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It
activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response.
Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully
described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and
TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the
inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6




Genomic Views
for TIRAP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIRAP gene promoter:
         HFH-3   HOXA3   HSF1 (long)   Tal-1beta   E47   c-Ets-1   FOXI1   AREB6   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TIRAP promoter sequence
   Search SABiosciences Chromatin IP Primers for TIRAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

TIRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIRAP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126153:  view genomic region     (about GC identifiers)

Start:
 126,152,960 bp from pter      End:
 126,168,740 bp from pter
Size:
 15,781 bases      Orientation:
 plus strand

Proteins
for TIRAP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753 (See protein sequence)
Recommended Name: Toll/interleukin-1 receptor domain-containing adapter protein  
Size: 221 amino acids; 23883 Da
Subunit: Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds
to BMX, PKR and TBK1. Does not interact with IRAK1, nor TLR9
Subcellular location: Cytoplasm (By similarity)
Caution: Variant Leu-180 has been reported to reduce TLR2 signal transduction (PubMed:17322885). In contrast,
PubMed:19509286 reports that this variant is fully active and has no effect on signal transduction pathways and
cytokine production
4 PDB 3D structures from and Proteopedia for TIRAP:
2Y92 (3D)        3UB2 (3D)        3UB3 (3D)        3UB4 (3D)    
Secondary accessions: B3KW65 Q56UH9 Q56UI0 Q8N5E5
Alternative splicing: 3 isoforms:  P58753-1   P58753-2   P58753-3   

Explore the universe of human proteins at neXtProt for TIRAP: NX_P58753

Post-translational modifications:

  • Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK1
  • Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P58753

    • TIRAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034750.1  NP_683708.1  

    ENSEMBL proteins: 
     ENSP00000446213   ENSP00000376446   ENSP00000376445   ENSP00000376447   ENSP00000436967  
    Reactome Protein details: P58753
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TIRAP
    OriGene Protein Over-expression Lysate: TIRAP
    OriGene Custom Protein Services for TIRAP 
    GenScript Custom Purified and Recombinant Proteins Services for TIRAP
    Novus Biologicals TIRAP Proteins
    Novus Biologicals TIRAP Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TIRAP
    Uscn Proteins for TIRAP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0030139endocytic vesicle ISS--
    GO:0032587ruffle membrane ISS--


    TIRAP for ontologies           About GeneDecksing



    TIRAP Antibody Products: 
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    OriGene Antibodies (see all 6): TIRAP
    OriGene Custom Antibody Services for TIRAP 
    GenScript Custom Superior Antibodies Services for TIRAP
    Novus Biologicals TIRAP Antibodies
    Abcam antibodies for TIRAP 
    Uscn Antibodies for TIRAP
    ThermoFisher Antibodies for TIRAP

    Assay Products for TIRAP: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIRAP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TIRAP

    Protein Domains /
    Families
    for TIRAP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TIRAP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000157 TIR_dom
     IPR017279 Tol-interleuk_rcpt_adapt_Tirap

    Graphical View of Domain Structure for InterPro Entry P58753

    ProtoNet protein and cluster: P58753

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Similarity: Contains 1 TIR domain


    Function
    for TIRAP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and
    TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the
    inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6

    miRNA
    Products:            		miRTarBase miRNAs that target TIRAP:
    hsa-mir-145 (MIRT004748)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIRAP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TIRAP (see all 9):
    hsa-miR-142-3p hsa-miR-4271 hsa-miR-3611 hsa-miR-1291 hsa-miR-2355-5p hsa-miR-637 hsa-miR-214* hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmid: TIRAP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIRAP (see all 4)
    OriGene shRNA RFP: TIRAP
    OriGene siRNA: TIRAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIRAP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TIRAP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIRAP (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIRAP (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TIRAP (NM_001039661)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIRAP 

    Cell Line
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    Search LifeMap BioReagents cell lines for TIRAP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIRAP

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IPI17161867
    GO:0005515protein binding IPI19509286
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS--
    GO:0030674protein binding, bridging NAS19509286
    GO:0035662Toll-like receptor 4 binding IPI19509286


    TIRAP for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TIRAP: Tiraptm1Medz Tiraptm1Aki
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tirap):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    TIRAP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TIRAP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		Activated TLR4 signalling0.63
    		Toll Like Receptor TLR6:TLR2 Cascade0.78
    		Toll Like Receptor 4 (TLR4) Cascade0.61
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll-Like Receptors Cascades0.53
    		MyD88:Mal cascade initiated on plasma membrane0.78
    2Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Inflammasome Activation Pathways0.29
    3Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway
    		Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway1.00
    		Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    4Immune response_Bacterial infections in normal airways
    		Immune response_Bacterial infections in normal airways1.00
    		Bacterial infections in CF airways0.78
    5Immune System
    		Immune System1.00
    		Innate Immune System0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TIRAP
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    2 R&D Systems Pathways for TIRAP
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TIRAP
        Toll-Like Receptors Pathway
    TRAF Pathway
    TLR-TRIF Pathway
    Toll Comparative Pathway
    Tec Kinases Signaling

    5 GeneGo (Thomson Reuters) Pathways for TIRAP
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    2 BioSystems Pathways for TIRAP 
        AGE/RAGE pathway
    Toll-like receptor signaling pathway

    5/9        Reactome Pathways for TIRAP (see all 9)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor 4 (TLR4) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    MyD88:Mal cascade initiated on plasma membrane


    3         Kegg Pathways  (Kegg details for TIRAP):
        Toll-like receptor signaling pathway
    Pertussis
    Tuberculosis


    TIRAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for TIRAP (P587531, 2, 3 ENSP000003764454) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-7298461 MINT-7298473 MINT-7298500 I2D: score=2 STRING: ENSP00000274335
    IRAK2O431871, 3, ENSP000002564584EBI-528644,EBI-447733 I2D: score=4 STRING: ENSP00000256458
    CCDC47Q96A331, 3, ENSP000002257264EBI-528644,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    IRAK1P516171, 3, ENSP000003589974EBI-528644,EBI-358664 I2D: score=1 STRING: ENSP00000358997
    IRAK4Q9NWZ31, 3EBI-528644,EBI-448378 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS19509286
    GO:0006954inflammatory response IEA--
    GO:0007166cell surface receptor signaling pathway ISS--
    GO:0007249I-kappaB kinase/NF-kappaB cascade IEA--


    TIRAP for ontologies           About GeneDecksing



    Drugs & Compounds
    for TIRAP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIRAP for compounds           About GeneDecksing

    EMD Millipore small molecules for TIRAP:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIRAP
    1 Novoseek chemical compound relationship for TIRAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 2.05 18 18070880 (7), 16439361 (5), 18292575 (1)

    Search CenterWatch for drugs/clinical trials and news about TIRAP 

    Transcripts
    for TIRAP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TIRAP gene (3 alternative transcripts): 
    NM_001039661.1  NM_148910.2  NM_052887.2  

    Unigene Cluster for TIRAP:

    Toll-interleukin 1 receptor (TIR) domain containing adaptor protein
    Hs.537126  [show with all ESTs]
    Unigene Representative Sequence: NM_001039661
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462401 ENST00000488598 ENST00000392679(uc001qdn.1 uc001qdo.1)
    ENST00000467006 ENST00000392678(uc001qdl.1 uc009zcb.1) ENST00000392680(uc001qdm.1)
    ENST00000479770

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIRAP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TIRAP (see all 9):
    hsa-miR-142-3p hsa-miR-4271 hsa-miR-3611 hsa-miR-1291 hsa-miR-2355-5p hsa-miR-637 hsa-miR-214* hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmid: TIRAP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIRAP (see all 4)
    OriGene shRNA RFP: TIRAP
    OriGene siRNA: TIRAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIRAP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIRAP (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TIRAP (NM_001039661)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIRAP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIRAP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIRAP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIRAP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIRAP

    Additional cDNA sequence: 

    AB446477.1 AF378129.1 AF406652.1 AK124298.1 AK313147.1 AY576785.1 AY576786.1 AY576787.1 
    BC032474.1 

    6 DOTS entries:

    DT.100754334  DT.92012742  DT.95096907  DT.100754331  DT.408184  DT.91748566 

    24/65 AceView cDNA sequences (see all 65):

    AF410783 AA135034 AA322884 BM762171 BX283452 BM762042 BM762452 AA346928 
    BQ687079 BQ877571 BU150555 BU163392 BQ686094 NM_148910 NM_052887 BQ649886 
    AA242959 BQ651057 CK430181 BQ645991 AK124298 AA219706 BQ645814 BQ649913 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TIRAP (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -                                         -     -     -     -                             -                     
    SP2:                          -                 -                       -     -     -     -                             -                     
    SP3:                          -                                         -           -     -     -                                             
    SP4:                          -     -     -     -                       -     -     -     -                             -                     
    SP5:                          -                                         -     -     -     -                                                   


    ECgene alternative splicing isoforms for TIRAP

    Expression
    for TIRAP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TIRAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIRAP

    SOURCE GeneReport for Unigene cluster: Hs.537126

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Tissue specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral
    blood leukocytes, lung, placenta, small intestine, thymus, colon and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including TIRAP (see all 7): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Antifungal Response in human mouse rat

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    Orthologs
    for TIRAP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TIRAP gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tirap1 , 5 toll-interleukin 1 receptor (TIR) domain-containing more1, 5 79.64(n)1
    79.64(a)1    		   9 (19.99 cM)5
    1171491  NM_001177845.11  NP_001171316.11 
     351845515 
    chicken
    (Gallus gallus)    		 Aves TIRAP1 toll-interleukin 1 receptor (TIR) domain containing more 58.96(n)
    53.77(a)    		   419715  NM_001024829.1  NP_001020000.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TIRAP6
    		 --
    		 43(a)
    		 1 ↔ 1
    		 GL343322.1(1122997-1125455)
    zebrafish
    (Danio rerio)    		 Actinopterygii tirap1 toll-interleukin 1 receptor (TIR) domain containing more 50.59(n)
    41.71(a)    		   403148  XM_002667112.2  XP_002667158.2 


    ENSEMBL Gene Tree for TIRAP (if available)
    TreeFam Gene Tree for TIRAP (if available) 

    Paralogs
    for TIRAP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TIRAP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Polymorphism: Genetic variations in TIRAP may influence susceptibility or resistance to invasive pneumococcal disease
    [MIM:610799], malaria [MIM:611162], and tuberculosis [MIM:607948]
    Polymorphism: Genetic variations in TIRAP influence susceptibility or resistance to bacterial invasion of the blood and
    define the bacteremia susceptibility locus 1 (BACTS1) [MIM:614382]


    10/267 NCBI SNPs in TIRAP are shown (see all 267)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs81773741,2
    		C,F,H,pathogenic126162843(+) GCTGTC/TGGGCC 4 S L mis1 ese321Minor allele frequency- T:0.11NS EA NA EU 7643
    rs939571,2
    		C,F,A,--126151073(-) CCTCCG/ACCTCC 2 -- us2k15Minor allele frequency- A:0.20NS NA 100
    rs1410360531,2
    		--126151098(+) GATTGC/TGCCAT 2 -- us2k10--------
    rs6555401,2
    		C,F,--126151242(-) GGGGGA/GAGACA 2 -- us2k1 trp38Minor allele frequency- G:0.12NA NS WA EA 458
    rs17866971,2
    		C,F,A,H,--126151247(+) TCCCCC/GCTGAG 2 -- us2k1 trp38Minor allele frequency- G:0.36NS NA EA 342
    rs81773421,2
    		C,F,--126151248(+) CCCCCC/GTGAGC 2 -- us2k1 trp37Minor allele frequency- G:0.07NS NA CSA WA EA 456
    rs1501216751,2
    		--126151276(+) AAGCCC/TTCTTC 2 -- us2k10--------
    rs1384772201,2
    		--126151414(+) GGGGAA/GTTTTT 2 -- us2k10--------
    rs5630111,2
    		C,F,H,--126151422(-) TTTAGA/CGTAAA 2 -- us2k120Minor allele frequency- C:0.14NS EA NA WA 2430
    rs81773431,2
    		C,F,--126151515(+) TTAAGC/AAAAGC 2 -- us2k16Minor allele frequency- A:0.13NS NA 220

    HapMap Linkage Disequilibrium report for TIRAP (126152960 - 126168740 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TIRAP: --
    Human Gene Mutation Database (HGMD): TIRAP

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TIRAP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TIRAP for disorders           About GeneDecksing

    OMIM gene information: 606252   
    OMIM disorders: 610799  611162  607948  
    20/37 diseases for TIRAP (see all 37):    About MalaCards
    pneumococcal disease, invasive, protection against    bacteremia, protection against    tuberculosis, protection against    malaria, protection against
    dengue hemorrhagic fever    hemorrhagic fever    extrapulmonary tuberculosis    haemophilus influenzae
    epiglottitis    systemic lupus erythematosus    lupus erythematosus    inflammatory bowel disease
    atopic dermatitis    candidiasis    bacteriuria    chronic lymphocytic leukemia
    lymphocytic leukemia    tuberculosis    rheumatoid arthritis    synovitis

    2 diseases from the University of Copenhagen DISEASES database for TIRAP:
    Tuberculosis     Malaria

    2 Novoseek disease relationships for TIRAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 24.8 1 18070880 (1)
    tumors 0 1 18070880 (1)

    Genetic Association Database (GAD): TIRAP
    Human Genome Epidemiology (HuGE) Navigator: TIRAP (35 documents)

    Export disorders for TIRAP gene to outside databases

    Publications
    for TIRAP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIRAP gene, integrated from 9 sources (see all 129):
    (articles sorted by number of sources associating them with TIRAP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PubMed id 11544529)1, 2, 3, 9 Fitzgerald K.A.... O'Neill L.A.J. (2001)
    2. TIRAP: an adapter molecule in the Toll signaling pathway. (PubMed id 11526399)1, 2, 3 Horng T.... Medzhitov R. (2001)
    3. A TIR domain variant of MyD88 adapter-like (Mal)/TIRA P results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. (PubMed id 19509286)1, 2, 9 Nagpal K....Golenbock D.T. (2009)
    4. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PubMed id 18292575)1, 2, 9 Semaan N....Sibilia J. (2008)
    5. The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk. (PubMed id 16284379)1, 4, 9 Xu J....Gronberg H. (2005)
    6. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. (PubMed id 21873236)1, 2 Valkov E.... Kobe B. (2011)
    7. IRAK1 and IRAK4 promote phosphorylation, ubiquitinati on, and degradation of MyD88 adaptor-like (Mal). (PubMed id 20400509)1, 2 Dunne A....O'Neill L.A. (2010)
    8. Low frequency of the TIRAP S180L polymorphism in Afri ca, and its potential role in malaria, sepsis, and leprosy. (PubMed id 19602285)1, 2 Hamann L....Schumann R.R. (2009)
    9. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2 Nakajima T....Kimura A. (2008)
    10. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. (PubMed id 17322885)1, 2 Khor C.C....Hill A.V.S. (2007)

    External Searches for TIRAP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TIRAP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114609 HGNC: 17192 AceView: TIRAP Ensembl:ENSG00000150455 euGenes: HUgn114609
    ECgene: TIRAP Kegg: 114609 H-InvDB: TIRAP

    Other Databases showing TIRAP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TIRAP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIRAP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/tirap/

    Intellectual Property
    for TIRAP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TIRAP gene:
    Search GeneIP for patents involving TIRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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