Aliases for TIRAP Gene
- TIR Domain Containing Adaptor Protein 2 3 5
- MyD88 Adapter-Like Protein 3 4
- Adaptor Protein Wyatt 3 4
- MyD88-2 3 4
- MAL 3 4
- Toll-Interleukin 1 Receptor (TIR) Domain-Containing Adaptor Protein 2
- Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein 3
- Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein 3
External Ids for TIRAP Gene
Previous GeneCards Identifiers for TIRAP Gene
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIRAP Gene
TIRAP (TIR Domain Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with TIRAP include Bacteremia, Protection Against and Invasive Pneumococcal Disease, Recurrent Isolated, 1. Among its related pathways are AGE/RAGE pathway and Activated TLR4 signalling. GO annotations related to this gene include protein homodimerization activity and protein binding, bridging.
UniProtKB/Swiss-Prot for TIRAP Gene
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.