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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIRAP Gene

protein-coding   GIFtS: 61
GCID: GC11P126153

Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor...

(Previous name: Toll-interleukin 1 receptor (TIR) domain-containing adaptor...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein1 2     Mal2
Adaptor Protein Wyatt2 3     Adapter Protein Wyatt2
MyD88-22 3     Toll-Like Receptor Adaptor Protein2
MyD88 Adapter-Like Protein2 3     Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein2
MyD88 Adapter-Like1     wyatt2
Toll-Interleukin 1 Receptor (TIR) Domain-Containing Adaptor Protein1     MAL3
BACTS12     TIR Domain-Containing Adapter Protein3

External Ids:    HGNC: 171921   Entrez Gene: 1146092   Ensembl: ENSG000001504557   OMIM: 6062525   UniProtKB: P587533   

Export aliases for TIRAP gene to outside databases

Previous GC identifers: GC11P128153 GC11P127665 GC11P126186 GC11P125690 GC11P125658 GC11P122098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIRAP Gene:
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify
pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns
and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The
protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune
system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the
inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all
variants have been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIRAP Gene: 
TIRAP (toll-interleukin 1 receptor (TIR) domain containing adaptor protein) is a protein-coding gene. Diseases associated with TIRAP include pneumococcal disease, invasive, protection against, and malaria, protection against, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response TLR signaling pathways. GO annotations related to this gene include protein binding, bridging and protein homodimerization activity.

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and
TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and
the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIRAP gene promoter:
         HFH-3   HOXA3   HSF1 (long)   Tal-1beta   E47   c-Ets-1   FOXI1   AREB6   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TIRAP promoter sequence
   Search SABiosciences Chromatin IP Primers for TIRAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

TIRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIRAP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126153:  view genomic region     (about GC identifiers)

Start:
126,152,960 bp from pter      End:
126,168,740 bp from pter
Size:
15,781 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753 (See protein sequence)
Recommended Name: Toll/interleukin-1 receptor domain-containing adapter protein  
Size: 221 amino acids; 23883 Da
Subunit: Homodimer. Also forms heterodimers with MYD88. May interact with PIK3AP1 (By similarity). Interacts with
TLR4 and IRAK2 via their respective TIR domains. Interacts with BMX and TBK1. Interacts with EIF2AK2. Does not
interact with IRAK1, nor TLR9
Subcellular location: Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane
Caution: Variant Leu-180 has been reported to reduce TLR2 signal transduction (PubMed:17322885). In contrast,
PubMed:19509286 reports that this variant is fully active and has no effect on signal transduction pathways and
cytokine production
5 PDB 3D structures from and Proteopedia for TIRAP:
2Y92 (3D)        3UB2 (3D)        3UB3 (3D)        3UB4 (3D)        4FZ5 (3D)    
Secondary accessions: B3KW65 Q56UH9 Q56UI0 Q8N5E5
Alternative splicing: 3 isoforms:  P58753-1   P58753-2   P58753-3   

Explore the universe of human proteins at neXtProt for TIRAP: NX_P58753

Explore proteomics data for TIRAP at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK
  • UniProtKB: Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P58753

  • TIRAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIRAP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001034750.1  NP_683708.1  

    ENSEMBL proteins: 
     ENSP00000446213   ENSP00000376446   ENSP00000376445   ENSP00000376447   ENSP00000436967  
    Reactome Protein details: P58753
    Human Recombinant Protein Products for TIRAP: 
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    Novus Biologicals TIRAP Proteins
    Novus Biologicals TIRAP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TIRAP
    Cloud-Clone Corp. Proteins for TIRAP 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19948740
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0030139endocytic vesicle ISS--
    GO:0032587ruffle membrane ISS--

    TIRAP for ontologies           About GeneDecksing



    TIRAP Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TIRAP 

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    Cloud-Clone Corp. ELISAs for TIRAP 
    Cloud-Clone Corp. CLIAs for TIRAP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000157 TIR_dom
     IPR017279 Tol-interleuk_rcpt_adapt_Tirap

    Graphical View of Domain Structure for InterPro Entry P58753

    ProtoNet protein and cluster: P58753

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Similarity: Contains 1 TIR domain


    TIRAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIRAP_HUMAN, P58753
    Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and
    TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and
    the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IPI17161867
    GO:0005515protein binding IPI11544529
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS--
    GO:0030674protein binding, bridging NAS19509286
    GO:0035662Toll-like receptor 4 binding IPI19509286
         
    TIRAP for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tirap):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    TIRAP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TIRAP: Tiraptm1Medz Tiraptm1Aki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIRAP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIRAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIRAP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIRAP 

    miRNA
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    miRTarBase miRNAs that target TIRAP:
    hsa-mir-145 (MIRT004748)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIRAP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TIRAP (see all 9):
    hsa-miR-142-3p hsa-miR-4271 hsa-miR-3611 hsa-miR-1291 hsa-miR-2355-5p hsa-miR-637 hsa-miR-214* hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidTIRAP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TIRAP (NM_001039661)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIRAP
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                         Customized lentivirus expression plasmids for stable overexpression of TIRAP 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIRAP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIRAP About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    4TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor TLR6:TLR2 Cascade0.86
    Toll Like Receptor 4 (TLR4) Cascade0.87
    Toll Like Receptor TLR1:TLR2 Cascade0.86
    Toll-Like Receptors Cascades0.87
    MyD88:Mal cascade initiated on plasma membrane0.86
    Toll Like Receptor 2 (TLR2) Cascade0.86
    5Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Bacterial infections in CF airways0.78

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TIRAP
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    2 R&D Systems Pathways for TIRAP
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TIRAP
        Toll-Like Receptors Pathway
    TRAF Pathway
    TLR-TRIF Pathway
    Toll Comparative Pathway
    Tec Kinases Signaling

    5 GeneGo (Thomson Reuters) Pathways for TIRAP
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    2 BioSystems Pathways for TIRAP
        AGE/RAGE pathway
    Toll-like receptor signaling pathway

    5/9        Reactome Pathways for TIRAP (see all 9)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor 4 (TLR4) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    MyD88:Mal cascade initiated on plasma membrane


    5         Kegg Pathways  (Kegg details for TIRAP):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Pertussis
    Tuberculosis
    Hepatitis B


    TIRAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for TIRAP (P587531, 2, 3 ENSP000003764454) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-7298461 MINT-7298473 MINT-7298500 I2D: score=2 STRING: ENSP00000274335
    IRAK2O431871, 3, ENSP000002564584EBI-528644,EBI-447733 I2D: score=4 STRING: ENSP00000256458
    CCDC47Q96A331, 3, ENSP000002257264EBI-528644,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    IRAK1P516171, 3, ENSP000003589974EBI-528644,EBI-358664 I2D: score=1 STRING: ENSP00000358997
    IRAK4Q9NWZ31, 3EBI-528644,EBI-448378 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS19509286
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ISS--

    TIRAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIRAP for compounds           About GeneDecksing

    EMD Millipore small molecules for TIRAP:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIRAP

    1 Novoseek inferred chemical compound relationship for TIRAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 2.05 18 18070880 (7), 16439361 (5), 18292575 (1)

    Search CenterWatch for drugs/clinical trials and news about TIRAP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIRAP gene (3 alternative transcripts): 
    NM_001039661.1  NM_148910.2  NM_052887.2  

    Unigene Cluster for TIRAP:

    Toll-interleukin 1 receptor (TIR) domain containing adaptor protein
    Hs.537126  [show with all ESTs]
    Unigene Representative Sequence: NM_001039661
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462401 ENST00000488598 ENST00000392679(uc001qdn.1 uc001qdo.1)
    ENST00000467006 ENST00000392678(uc001qdl.1 uc009zcb.1) ENST00000392680(uc001qdm.1)
    ENST00000479770
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TIRAP (see all 9):
    hsa-miR-142-3p hsa-miR-4271 hsa-miR-3611 hsa-miR-1291 hsa-miR-2355-5p hsa-miR-637 hsa-miR-214* hsa-miR-648
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIRAP

    Additional mRNA sequence: 

    AB446477.1 AF378129.1 AF406652.1 AK124298.1 AK313147.1 AY576785.1 AY576786.1 AY576787.1 
    BC032474.1 

    6 DOTS entries:

    DT.100754334  DT.92012742  DT.95096907  DT.100754331  DT.408184  DT.91748566 

    24/65 AceView cDNA sequences (see all 65):

    BQ686094 NM_148910 BM762171 BQ877571 AA135034 BU163392 AF410783 BM762452 
    NM_052887 AA322884 BX283452 AA346928 BU150555 BQ687079 BM762042 BQ651026 
    BE884911 BQ645814 BC032474 AA242959 BQ646740 BU608542 AA219706 AA317537 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TIRAP (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -                                         -     -     -     -                             -                     
    SP2:                          -                 -                       -     -     -     -                             -                     
    SP3:                          -                                         -           -     -     -                                             
    SP4:                          -     -     -     -                       -     -     -     -                             -                     
    SP5:                          -                                         -     -     -     -                                                   


    ECgene alternative splicing isoforms for TIRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TIRAP Expression
    About this image


    See TIRAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIRAP

    SOURCE GeneReport for Unigene cluster: Hs.537126

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Tissue specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in
    peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including TIRAP (see all 7): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Antifungal Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TIRAP gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tirap1 , 5 toll-interleukin 1 receptor (TIR) domain-containing more1, 5 79.64(n)1
    79.64(a)1
      9 (19.99 cM)5
    1171491  NM_001177845.11  NP_001171316.11 
     351845515 
    chicken
    (Gallus gallus)
    Aves TIRAP1 toll-interleukin 1 receptor (TIR) domain containing more 58.96(n)
    53.77(a)
      419715  NM_001024829.1  NP_001020000.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIRAP6
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL343322.1(1123000-1125455)
    zebrafish
    (Danio rerio)
    Actinopterygii tirap1 toll-interleukin 1 receptor (TIR) domain containing more 50.59(n)
    41.71(a)
      403148  XM_002667112.2  XP_002667158.2 


    ENSEMBL Gene Tree for TIRAP (if available)
    TreeFam Gene Tree for TIRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Polymorphism: Genetic variations in TIRAP may influence susceptibility or resistance to invasive pneumococcal
    disease [MIM:610799], malaria [MIM:611162], and tuberculosis [MIM:607948]
    Polymorphism: Genetic variations in TIRAP influence susceptibility or resistance to bacterial invasion of the
    blood and define the bacteremia susceptibility locus 1 (BACTS1) [MIM:614382]


    10/341 SNPs in TIRAP are shown (see all 341)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81773741,2,4
    C,F,Hpathogenic1126030768(+) GCTGTC/TGGGCC 4 S L mis1 ese321Minor allele frequency- T:0.11NS EA NA EU 7643
    rs939571,2
    C,F,A--126018998(-) CCTCCG/ACCTCC 2 -- us2k15Minor allele frequency- A:0.20NS NA 100
    rs1410360531,2
    --126019023(+) GATTGC/TGCCAT 2 -- us2k10--------
    rs6555401,2
    C,F--126019167(-) GGGGGA/GAGACA 2 -- us2k1 trp38Minor allele frequency- G:0.12NA NS WA EA 458
    rs17866971,2
    C,F,A,H--126019172(+) TCCCCC/GCTGAG 2 -- us2k1 trp38Minor allele frequency- G:0.36NS NA EA 342
    rs81773421,2
    C,F--126019173(+) CCCCCC/GTGAGC 2 -- us2k1 trp37Minor allele frequency- G:0.07NS NA CSA WA EA 456
    rs1501216751,2
    --126019201(+) AAGCCC/TTCTTC 2 -- us2k10--------
    rs1384772201,2
    --126019339(+) GGGGAA/GTTTTT 2 -- us2k10--------
    rs5630111,2
    C,F,H--126019347(-) TTTAGA/CGTAAA 2 -- us2k120Minor allele frequency- C:0.14NS EA NA WA 2430
    rs81773431,2
    C,F--126019440(+) TTAAGC/AAAAGC 2 -- us2k16Minor allele frequency- A:0.13NS NA 220

    HapMap Linkage Disequilibrium report for TIRAP (126152960 - 126168740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TIRAP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664251CNV Deletion23128226
    esv2660319CNV Deletion23128226
    nsv898441CNV Loss21882294
    nsv898440CNV Loss21882294
    nsv826122CNV Loss20364138


    Human Gene Mutation Database (HGMD): TIRAP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIRAP
    DNA2.0 Custom Variant and Variant Library Synthesis for TIRAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606252   
    OMIM disorders: 610799  611162  607948  
    20/31 diseases for TIRAP (see all 31):    About MalaCards
    pneumococcal disease, invasive, protection against    malaria, protection against    bacteriuria    extrapulmonary tuberculosis
    epiglottitis    tuberculosis, protection against    dengue hemorrhagic fever    tuberculosis
    pertussis    hemorrhagic fever    candidiasis    leprosy
    synovitis    malaria    influenza    atopic dermatitis
    meningitis    dermatitis    chronic lymphocytic leukemia    inflammatory bowel disease

    2 diseases from the University of Copenhagen DISEASES database for TIRAP:
    Tuberculosis     Malaria

    TIRAP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for TIRAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 24.8 1 18070880 (1)
    tumors 0 1 18070880 (1)

    Genetic Association Database (GAD): TIRAP
    Human Genome Epidemiology (HuGE) Navigator: TIRAP (35 documents)

    Export disorders for TIRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIRAP gene, integrated from 9 sources (see all 137):
    (articles sorted by number of sources associating them with TIRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PubMed id 11544529)1, 2, 3, 9 Fitzgerald K.A.... O'Neill L.A.J. (2001)
    2. Low frequency of the TIRAP S180L polymorphism in Afri ca, and its potential role in malaria, sepsis, and leprosy. (PubMed id 19602285)1, 2, 4 Hamann L....Schumann R.R. (2009)
    3. TIRAP: an adapter molecule in the Toll signaling pathway. (PubMed id 11526399)1, 2, 3 Horng T.... Medzhitov R. (2001)
    4. Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups. (PubMed id 19693265)1, 4, 9 Dissanayeke S.R....Levin M. (2009)
    5. A TIR domain variant of MyD88 adapter-like (Mal)/TIRA P results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. (PubMed id 19509286)1, 2, 9 Nagpal K....Golenbock D.T. (2009)
    6. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. (PubMed id 18417424)1, 4, 9 Castiblanco J....Anaya J.M. (2008)
    7. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PubMed id 18292575)1, 2, 9 Semaan N....Sibilia J. (2008)
    8. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. (PubMed id 16991088)1, 4, 9 Hawn T.R....Aderem A. (2006)
    9. AIP1 functions as Arf6-GAP to negatively regulate TLR 4 signaling. (PubMed id 19948740)1, 2, 9 Wan T....Min W. (2010)
    10. Genetic variation of the human urinary tract innate i mmune response and asymptomatic bacteriuria in women. (PubMed id 20016852)1, 4, 9 Hawn T.R....Hooton T.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114609 HGNC: 17192 AceView: TIRAP Ensembl:ENSG00000150455 euGenes: HUgn114609
    ECgene: TIRAP Kegg: 114609 H-InvDB: TIRAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIRAP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/tirap/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIRAP gene:
    Search GeneIP for patents involving TIRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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