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TIRAP Gene

protein-coding   GIFtS: 61
GCID: GC11P126153

Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor...

(Previous name: Toll-interleukin 1 receptor (TIR) domain-containing adaptor...)
  See TIRAP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein1 2     Mal2
Adaptor Protein Wyatt2 3     Adapter Protein Wyatt2
MyD88-22 3     Toll-Like Receptor Adaptor Protein2
MyD88 Adapter-Like Protein2 3     Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein2
BACTS12 5     wyatt2
MyD88 Adapter-Like1     MAL3
Toll-Interleukin 1 Receptor (TIR) Domain-Containing Adaptor Protein1     TIR Domain-Containing Adapter Protein3

External Ids:    HGNC: 171921   Entrez Gene: 1146092   Ensembl: ENSG000001504557   OMIM: 6062525   UniProtKB: P587533   
ORGUL members:         

Export aliases for TIRAP gene to outside databases

Previous GC identifers: GC11P128153 GC11P127665 GC11P126186 GC11P125690 GC11P125658 GC11P122098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIRAP Gene:
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify
pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns
and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The
protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune
system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the
inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all
variants have been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIRAP Gene:
TIRAP (toll-interleukin 1 receptor (TIR) domain containing adaptor protein) is a protein-coding gene. Diseases associated with TIRAP include pneumococcal disease, invasive, protection against, and bacteremia, protection against. GO annotations related to this gene include protein binding, bridging and protein homodimerization activity.

UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and
TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and
the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIRAP gene promoter:
         HFH-3   HOXA3   HSF1 (long)   Tal-1beta   E47   c-Ets-1   FOXI1   AREB6   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TIRAP promoter sequence
   Search Chromatin IP Primers for TIRAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

TIRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIRAP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126153:  view genomic region     (about GC identifiers)

Start:
126,152,960 bp from pter      End:
126,168,740 bp from pter
Size:
15,781 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753 (See protein sequence)
Recommended Name: Toll/interleukin-1 receptor domain-containing adapter protein  
Size: 221 amino acids; 23883 Da
Subunit: Homodimer. Also forms heterodimers with MYD88. May interact with PIK3AP1 (By similarity). Interacts with
TLR4 and IRAK2 via their respective TIR domains. Interacts with BMX and TBK1. Interacts with EIF2AK2. Does not
interact with IRAK1, nor TLR9
Caution: Variant Leu-180 has been reported to reduce TLR2 signal transduction (PubMed:17322885). In contrast,
PubMed:19509286 reports that this variant is fully active and has no effect on signal transduction pathways and
cytokine production
6 PDB 3D structures from and Proteopedia for TIRAP:
2Y92 (3D)        3UB2 (3D)        3UB3 (3D)        3UB4 (3D)        4FZ5 (3D)        4LQD (3D)    
Secondary accessions: B3KW65 Q56UH9 Q56UI0 Q8N5E5
Alternative splicing: 3 isoforms:  P58753-1   P58753-2   P58753-3   

Explore the universe of human proteins at neXtProt for TIRAP: NX_P58753

Explore proteomics data for TIRAP at MOPED

Post-translational modifications: 

  • Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK1
  • Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIRAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034750.1  NP_683708.1  

    ENSEMBL proteins: 
     ENSP00000446213   ENSP00000376446   ENSP00000376445   ENSP00000376447   ENSP00000436967  
    Reactome Protein details: P58753

    TIRAP Human Recombinant Protein Products:

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    Novus Biologicals TIRAP Proteins
    Novus Biologicals TIRAP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TIRAP
    Cloud-Clone Corp. Proteins for TIRAP

     
    Search eBioscience for Proteins for TIRAP 

    TIRAP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for TIRAP
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    LSBio Antibodies in human, mouse, rat for TIRAP

    TIRAP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIRAP
    Cloud-Clone Corp. CLIAs for TIRAP
    Search eBioscience for ELISAs for TIRAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000157 TIR_dom
     IPR017279 Tol-interleuk_rcpt_adapt_Tirap

    Graphical View of Domain Structure for InterPro Entry P58753

    ProtoNet protein and cluster: P58753

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TIRAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIRAP_HUMAN, P58753
    Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and
    TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and
    the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IPI17161867
    GO:0005515protein binding IPI11544529
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS--
    GO:0030674protein binding, bridging NAS19509286
    GO:0035662Toll-like receptor 4 binding IPI19509286
         
    Find genes that share ontologies with TIRAP           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tirap):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with TIRAP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TIRAP: Tiraptm1Medz Tiraptm1Aki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIRAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIRAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIRAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIRAP

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIRAP:
    hsa-mir-145-5p (MIRT004748)

    Block miRNA regulation of human, mouse, rat TIRAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIRAP (see all 9):
    hsa-miR-142-3p hsa-miR-4271 hsa-miR-3611 hsa-miR-1291 hsa-miR-2355-5p hsa-miR-637 hsa-miR-214* hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidTIRAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIRAP
    Predesigned siRNA for gene silencing in human, mouse, rat TIRAP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIRAP

    Clone
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    OriGene clones in human, mouse for TIRAP (see all 13)
    OriGene ORF clones in mouse, rat for TIRAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIRAP (NM_001039661)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIRAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIRAP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TIRAP
    Browse ESI BIO Cell Lines and PureStem Progenitors for TIRAP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIRAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIRAP_HUMAN, P58753: Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19948740
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0030139endocytic vesicle ISS--
    GO:0032587ruffle membrane ISS--

    Find genes that share ontologies with TIRAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TIRAP About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    Inflammasome Activation Pathways0.51
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    4Toll Comparative Pathway
    Toll Comparative Pathway0.61
    TLR-TRIF Pathway0.61
    5TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41


    Find genes that share SuperPaths with TIRAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TIRAP
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TIRAP
        Toll-Like Receptors Pathway
    TRAF Pathway
    TLR-TRIF Pathway
    Toll Comparative Pathway
    Tec Kinases Signaling

    5 GeneGo (Thomson Reuters) Pathways for TIRAP
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    3 BioSystems Pathways for TIRAP
        AGE/RAGE pathway
    Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway

    2 Reactome Pathways for TIRAP
        Toll Like Receptor 4 (TLR4) Cascade
    MyD88:Mal cascade initiated on plasma membrane


    5 Kegg Pathways  (Kegg details for TIRAP):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Pertussis
    Tuberculosis
    Hepatitis B

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TIRAP (see all 7): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TIRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIRAP (P587531, 2, 3 ENSP000003764454) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-528644,EBI-79464 MINT-7298461 MINT-7298473 MINT-7298500 I2D: score=2 STRING: ENSP00000274335
    IRAK2O431871, 3, ENSP000002564584EBI-528644,EBI-447733 I2D: score=4 STRING: ENSP00000256458
    CCDC47Q96A331, 3, ENSP000002257264EBI-528644,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    IRAK1P516171, 3, ENSP000003589974EBI-528644,EBI-358664 I2D: score=1 STRING: ENSP00000358997
    IRAK4Q9NWZ31, 3EBI-528644,EBI-448378 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS19509286
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ISS--

    Find genes that share ontologies with TIRAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIRAP

    1 Novoseek inferred chemical compound relationship for TIRAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 2.05 18 18070880 (7), 16439361 (5), 18292575 (1)



    Find genes that share compounds with TIRAP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIRAP gene (3 alternative transcripts): 
    NM_001039661.1  NM_148910.2  NM_052887.2  

    Unigene Cluster for TIRAP:

    Toll-interleukin 1 receptor (TIR) domain containing adaptor protein
    Hs.537126  [show with all ESTs]
    Unigene Representative Sequence: NM_001039661
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462401 ENST00000488598 ENST00000392679(uc001qdn.1 uc001qdo.1)
    ENST00000467006 ENST00000392678(uc001qdl.1 uc009zcb.1) ENST00000392680(uc001qdm.1)
    ENST00000479770
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TIRAP (see all 9):
    hsa-miR-142-3p hsa-miR-4271 hsa-miR-3611 hsa-miR-1291 hsa-miR-2355-5p hsa-miR-637 hsa-miR-214* hsa-miR-648
    SwitchGear 3'UTR luciferase reporter plasmidTIRAP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TIRAP
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TIRAP (NM_001039661)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIRAP
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TIRAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIRAP
      QuantiTect SYBR Green Assays in human, mouse, rat TIRAP
      QuantiFast Probe-based Assays in human, mouse, rat TIRAP

    Additional mRNA sequence: 

    AB446477.1 AF378129.1 AF406652.1 AK124298.1 AK313147.1 AY576785.1 AY576786.1 AY576787.1 
    BC032474.1 

    6 DOTS entries:

    DT.100754334  DT.92012742  DT.95096907  DT.100754331  DT.408184  DT.91748566 

    Selected AceView cDNA sequences (see all 65):

    BU150555 AA322884 AA135034 BM762452 NM_148910 BQ686094 BM762171 BQ877571 
    NM_052887 BU163392 BM762042 AF410783 AA346928 BQ687079 BX283452 BQ646740 
    AA384704 BE884911 BQ651057 AF378129 AA317537 AA242959 BQ019169 AK124298 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TIRAP (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -                                         -     -     -     -                             -                     
    SP2:                          -                 -                       -     -     -     -                             -                     
    SP3:                          -                                         -           -     -     -                                             
    SP4:                          -     -     -     -                       -     -     -     -                             -                     
    SP5:                          -                                         -     -     -     -                                                   


    ECgene alternative splicing isoforms for TIRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TIRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TIRAP Expression
    About this image

    TIRAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIRAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.537126

    UniProtKB/Swiss-Prot: TIRAP_HUMAN, P58753
    Tissue specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in
    peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TIRAP (see all 7): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Antifungal Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TIRAP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tirap1 , 5 toll-interleukin 1 receptor (TIR) domain-containing more1, 5 79.49(n)1
    79.64(a)1
      9 (19.99 cM)5
    1171491  NM_001177845.11  NP_001171316.11 
     351845515 
    chicken
    (Gallus gallus)
    Aves TIRAP1 toll-interleukin 1 receptor (TIR) domain containing more 58.96(n)
    53.77(a)
      419715  NM_001024829.1  NP_001020000.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIRAP6
    toll-interleukin 1 receptor (TIR) domain containin...
    44(a)
    1 ↔ 1
    GL343322.1(1123000-1125455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004916931 uncharacterized LOC100491693 49.03(n)
    42.33(a)
      100491693  XM_004916417.1  XP_004916474.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tirap1 toll-interleukin 1 receptor (TIR) domain containing more 50.58(n)
    41.29(a)
      403148  XM_002667112.3  XP_002667158.2 


    ENSEMBL Gene Tree for TIRAP (if available)
    TreeFam Gene Tree for TIRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    TIRAP_HUMAN, P58753: Genetic variations in TIRAP may influence susceptibility or resistance to invasive pneumococcal
    disease [MIM:610799], malaria [MIM:611162], and tuberculosis [MIM:607948]
    TIRAP_HUMAN, P58753: Genetic variations in TIRAP influence susceptibility or resistance to bacterial invasion of the
    blood and define the bacteremia susceptibility locus 1 (BACTS1) [MIM:614382]


    Selected SNPs for TIRAP (see all 341)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81773741,2,,4
    C,F,Hpathogenic1126030768(+) GCTGTC/TGGGCC 4 S L mis1 ese321Minor allele frequency- T:0.11NS EA NA EU 7643
    rs939571,2
    C,F,A--126018998(-) CCTCCG/ACCTCC 2 -- us2k15Minor allele frequency- A:0.20NS NA 100
    rs1410360531,2
    --126019023(+) GATTGC/TGCCAT 2 -- us2k10--------
    rs6555401,2
    C,F--126019167(-) GGGGGA/GAGACA 2 -- us2k1 trp38Minor allele frequency- G:0.12NA NS WA EA 458
    rs17866971,2
    C,F,A,H--126019172(+) TCCCCC/GCTGAG 2 -- us2k1 trp38Minor allele frequency- G:0.36NS NA EA 342
    rs81773421,2
    C,F--126019173(+) CCCCCC/GTGAGC 2 -- us2k1 trp37Minor allele frequency- G:0.07NS NA CSA WA EA 456
    rs1501216751,2
    --126019201(+) AAGCCC/TTCTTC 2 -- us2k10--------
    rs1384772201,2
    --126019339(+) GGGGAA/GTTTTT 2 -- us2k10--------
    rs5630111,2
    C,F,H--126019347(-) TTTAGA/CGTAAA 2 -- us2k120Minor allele frequency- C:0.14NS EA NA WA 2430
    rs81773431,2
    C,F--126019440(+) TTAAGC/AAAAGC 2 -- us2k16Minor allele frequency- A:0.13NS NA 220

    HapMap Linkage Disequilibrium report for TIRAP (126152960 - 126168740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TIRAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664251CNV Deletion23128226
    esv2660319CNV Deletion23128226
    nsv898441CNV Loss21882294
    nsv898440CNV Loss21882294
    nsv826122CNV Loss20364138

    Human Gene Mutation Database (HGMD): TIRAP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIRAP
    DNA2.0 Custom Variant and Variant Library Synthesis for TIRAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606252   
    OMIM disorders: 610799  614382  611162  607948  
    10 diseases for TIRAP:    
    About MalaCards
    pneumococcal disease, invasive, protection against    bacteremia, protection against    malaria, protection against    bacteriuria
    bacteremia    tuberculosis, protection against    extrapulmonary tuberculosis    pelvic inflammatory disease
    tuberculosis    malaria

    2 diseases from the University of Copenhagen DISEASES database for TIRAP:
    Tuberculosis     Malaria

    Find genes that share disorders with TIRAP           About GenesLikeMe

    2 Novoseek inferred disease relationships for TIRAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 24.8 1 18070880 (1)
    tumors 0 1 18070880 (1)

    Genetic Association Database (GAD): TIRAP
    Human Genome Epidemiology (HuGE) Navigator: TIRAP (35 documents)

    Export disorders for TIRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIRAP gene, integrated from 10 sources (see all 142):
    (articles sorted by number of sources associating them with TIRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PubMed id 11544529)1, 2, 3, 9 Fitzgerald K.A.... O'Neill L.A.J. (Nature 2001)
    2. Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. (PubMed id 19602285)1, 2, 4 Hamann L.... Schumann R.R. (BMC Med. Genet. 2009)
    3. TIRAP: an adapter molecule in the Toll signaling pathway. (PubMed id 11526399)1, 2, 3 Horng T.... Medzhitov R. (Nat. Immunol. 2001)
    4. Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups. (PubMed id 19693265)1, 4, 9 Dissanayeke S.R....Levin M. (PLoS ONE 2009)
    5. A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. (PubMed id 19509286)1, 2, 9 Nagpal K.... Golenbock D.T. (J. Biol. Chem. 2009)
    6. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. (PubMed id 18417424)1, 4, 9 Castiblanco J....Anaya J.M. (Infect. Genet. Evol. 2008)
    7. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PubMed id 18292575)1, 2, 9 Semaan N.... Sibilia J. (J. Immunol. 2008)
    8. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. (PubMed id 16991088)1, 4, 9 Hawn T.R....Aderem A. (J. Infect. Dis. 2006)
    9. AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. (PubMed id 19948740)1, 2, 9 Wan T.... Min W. (J. Biol. Chem. 2010)
    10. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. (PubMed id 20016852)1, 4, 9 Hawn T.R....Hooton T.M. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114609 HGNC: 17192 AceView: TIRAP Ensembl:ENSG00000150455 euGenes: HUgn114609
    ECgene: TIRAP Kegg: 114609 H-InvDB: TIRAP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIRAP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/tirap/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIRAP gene:
    Search GeneIP for patents involving TIRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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