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Aliases for TIRAP Gene

Aliases for TIRAP Gene

  • Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein 2 3
  • MyD88 Adapter-Like Protein 3 4
  • Adaptor Protein Wyatt 3 4
  • MyD88-2 3 4
  • BACTS1 3 6
  • MAL 3 4
  • Toll-Interleukin 1 Receptor (TIR) Domain-Containing Adaptor Protein 2
  • Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein 3
  • TIR Domain-Containing Adapter Protein 4
  • Toll-Like Receptor Adaptor Protein 3
  • Adapter Protein Wyatt 3
  • MyD88 Adapter-Like 2
  • Wyatt 3

External Ids for TIRAP Gene

Summaries for TIRAP Gene

Entrez Gene Summary for TIRAP Gene

  • The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIRAP Gene

TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with TIRAP include bacteremia, protection against and bacteriuria. Among its related pathways are Akt Signaling and Tuberculosis. GO annotations related to this gene include protein homodimerization activity and protein binding, bridging.

UniProtKB/Swiss-Prot for TIRAP Gene

  • Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIRAP Gene

Genomics for TIRAP Gene

Genomic Location for TIRAP Gene

Start:
126,282,905 bp from pter
End:
126,298,845 bp from pter
Size:
15,941 bases
Orientation:
Plus strand

Genomic View for TIRAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIRAP Gene

Regulatory Elements for TIRAP Gene

Proteins for TIRAP Gene

  • Protein details for TIRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58753-TIRAP_HUMAN
    Recommended name:
    Toll/interleukin-1 receptor domain-containing adapter protein
    Protein Accession:
    P58753
    Secondary Accessions:
    • B3KW65
    • Q56UH9
    • Q56UI0
    • Q8N5E5

    Protein attributes for TIRAP Gene

    Size:
    221 amino acids
    Molecular mass:
    23883 Da
    Quaternary structure:
    • Homodimer. Also forms heterodimers with MYD88. May interact with PIK3AP1 (By similarity). Interacts with TLR4 and IRAK2 via their respective TIR domains. Interacts with BMX and TBK1. Interacts with EIF2AK2. Does not interact with IRAK1, nor TLR9.

    Three dimensional structures from OCA and Proteopedia for TIRAP Gene

    Alternative splice isoforms for TIRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIRAP Gene

Proteomics data for TIRAP Gene at MOPED

Post-translational modifications for TIRAP Gene

  • Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK
  • Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIRAP Gene

No data available for DME Specific Peptides for TIRAP Gene

Domains for TIRAP Gene

Protein Domains for TIRAP Gene

UniProtKB/Swiss-Prot:

TIRAP_HUMAN
Domain:
  • Contains 1 TIR domain.:
    • P58753
genes like me logo Genes that share domains with TIRAP: view

No data available for Gene Families for TIRAP Gene

Function for TIRAP Gene

Molecular function for TIRAP Gene

UniProtKB/Swiss-Prot Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.

Gene Ontology (GO) - Molecular Function for TIRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IPI 17161867
GO:0005515 protein binding IPI 11544529
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS --
GO:0030674 protein binding, bridging NAS 19509286
GO:0035662 Toll-like receptor 4 binding IPI 19509286
genes like me logo Genes that share ontologies with TIRAP: view
genes like me logo Genes that share phenotypes with TIRAP: view

Animal Models for TIRAP Gene

MGI Knock Outs for TIRAP:

miRNA for TIRAP Gene

miRTarBase miRNAs that target TIRAP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TIRAP Gene

Localization for TIRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIRAP Gene

Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIRAP Gene COMPARTMENTS Subcellular localization image for TIRAP gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TIRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0030139 endocytic vesicle ISS --
genes like me logo Genes that share ontologies with TIRAP: view

Pathways for TIRAP Gene

genes like me logo Genes that share pathways with TIRAP: view

Gene Ontology (GO) - Biological Process for TIRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 19509286
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with TIRAP: view

Compounds for TIRAP Gene

(1) Novoseek inferred chemical compound relationships for TIRAP Gene

Compound -log(P) Hits PubMed IDs
tyrosine 2.05 13
genes like me logo Genes that share compounds with TIRAP: view

Transcripts for TIRAP Gene

Unigene Clusters for TIRAP Gene

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIRAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8: - - - - -
SP9: - - -
SP10: -
SP11: - - - - -

Relevant External Links for TIRAP Gene

GeneLoc Exon Structure for
TIRAP
ECgene alternative splicing isoforms for
TIRAP

Expression for TIRAP Gene

mRNA expression in normal human tissues for TIRAP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIRAP Gene

SOURCE GeneReport for Unigene cluster for TIRAP Gene Hs.537126

mRNA Expression by UniProt/SwissProt for TIRAP Gene

P58753-TIRAP_HUMAN
Tissue specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain
genes like me logo Genes that share expressions with TIRAP: view

Orthologs for TIRAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIRAP 36
  • 99.4 (n)
  • 100 (a)
TIRAP 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIRAP 36
  • 82.27 (n)
  • 80 (a)
TIRAP 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIRAP 36
  • 82.96 (n)
  • 79.64 (a)
TIRAP 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tirap 36
  • 79.49 (n)
  • 79.64 (a)
Tirap 16
Tirap 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIRAP 37
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIRAP 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tirap 36
  • 80.24 (n)
  • 78.73 (a)
chicken
(Gallus gallus)
Aves TIRAP 36
  • 58.96 (n)
  • 53.77 (a)
TIRAP 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIRAP 37
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491693 36
  • 49.03 (n)
  • 42.33 (a)
zebrafish
(Danio rerio)
Actinopterygii tirap 36
  • 50.58 (n)
  • 41.29 (a)
tirap 37
  • 34 (a)
OneToOne
Species with no ortholog for TIRAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIRAP Gene

ENSEMBL:
Gene Tree for TIRAP (if available)
TreeFam:
Gene Tree for TIRAP (if available)

Paralogs for TIRAP Gene

No data available for Paralogs for TIRAP Gene

Variants for TIRAP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TIRAP Gene

P58753-TIRAP_HUMAN
Genetic variations in TIRAP influence susceptibility or resistance to bacterial invasion of the blood and define the bacteremia susceptibility locus 1 (BACTS1) [MIM:614382]

Sequence variations from dbSNP and Humsavar for TIRAP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs93957 -- 126,281,178(-) CCTCC(A/G)CCTCC upstream-variant-2KB
rs563011 -- 126,281,527(-) TTTAG(A/C)GTAAA upstream-variant-2KB
rs595022 -- 126,287,084(-) gattc(A/G)gcagc intron-variant
rs595209 -- 126,292,326(+) AGTGG(A/C)GCAAC intron-variant
rs598686 -- 126,286,316(-) acaat(C/T)tcagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIRAP Gene

Variant ID Type Subtype PubMed ID
nsv898440 CNV Loss 21882294
nsv898441 CNV Loss 21882294
nsv826122 CNV Loss 20364138
esv2660319 CNV Deletion 23128226
esv2664251 CNV Deletion 23128226

Relevant External Links for TIRAP Gene

HapMap Linkage Disequilibrium report
TIRAP
Human Gene Mutation Database (HGMD)
TIRAP

Disorders for TIRAP Gene

(4) OMIM Diseases for TIRAP Gene (606252)

(2) University of Copenhagen DISEASES for TIRAP Gene

(2) Novoseek inferred disease relationships for TIRAP Gene

Disease -log(P) Hits PubMed IDs
necrosis 24.8 1
tumors 0 1

Relevant External Links for TIRAP

Genetic Association Database (GAD)
TIRAP
Human Genome Epidemiology (HuGE) Navigator
TIRAP
genes like me logo Genes that share disorders with TIRAP: view

No data available for UniProtKB/Swiss-Prot for TIRAP Gene

Publications for TIRAP Gene

  1. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PMID: 11544529) Fitzgerald K.A. … O'Neill L.A.J. (Nature 2001) 2 3 4 23
  2. The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk. (PMID: 16284379) Xu J. … GrAPnberg H. (Cancer Epidemiol. Biomarkers Prev. 2005) 3 23 49
  3. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. (PMID: 16991088) Hawn T.R. … Aderem A. (J. Infect. Dis. 2006) 3 23 49
  4. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PMID: 18292575) Semaan N. … Sibilia J. (J. Immunol. 2008) 3 4 23
  5. The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. (PMID: 18369480) Caws M. … Farrar J. (PLoS Pathog. 2008) 3 23 49

Products for TIRAP Gene

Sources for TIRAP Gene

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