TIPRL Gene
protein-coding GIFtS: 47
GCID: GC01P168148
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TIP41, TOR signaling pathway regulator-like (S. cerevisiae)(Previous names: TIP41, TOR signalling pathway regulator-like (S. cerevisiae)...)
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Aliases
for TIPRL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae)1 2 | | Type 2A-Interacting Protein2 3 | | TIP411 2 5 | | MGC37941 | | TIP2 3 5 | | TIP41, TOR Signalling Pathway Regulator-Like (S. Cerevisiae)1 | | DJ69E11.31 | | Putative MAPK Activating Protein2 | | Putative MAPK-Activating Protein PM102 3 | | TIP41-Like Protein2 |
Export aliases for TIPRL gene to outside databasesPrevious GC identifers: GC01P164880 GC01P166414 GC01P139392 |
Summaries
for TIPRL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TIPRL:
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 (PubMed 17384681)).(supplied by OMIM, Nov 2010)
UniProtKB/Swiss-Prot: TIPRL_HUMAN, O75663Function: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalyticactivity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May playa role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair
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Genomic Views
for TIPRL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TIPRL gene promoter:
Pbx1a Nkx2-5 AP-2gamma Cdc5 Evi-1 FOXJ2 (long isoform) AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIPRL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIPRL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.2 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q23.2TIPRL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P168148: view genomic region
(about GC identifiers)
Start:
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168,148,171 bp from pter |
End:
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168,171,352 bp from pter |
Size:
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23,182 bases |
Orientation:
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plus strand |
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Proteins
for TIPRL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIPRL_HUMAN, O75663 (See
protein sequence)Recommended Name: TIP41-like protein Size: 272 amino acids; 31444 Da
Subunit: Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C andPPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2APP2A(C):alpha-4 complex
Subcellular location: Cytoplasm
Secondary accessions: B2R8V3 Q5HYB2 Q8IZ86Alternative splicing: 2 isoforms: O75663-1 O75663-2 Explore the universe of human proteins at neXtProt for TIPRL: NX_O75663
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75663
TIPRL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001026970.1 NP_690866.1
ENSEMBL proteins: ENSP00000356807 ENSP00000356804
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
IEA | -- |
TIPRL for ontologies About GeneDecksing
TIPRL Antibody Products:
Assay Products for TIPRL: |
Protein
Domains /
Families
for TIPRL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIPRL for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75663ProtoNet protein and cluster: O75663 UniProtKB/Swiss-Prot: TIPRL_HUMAN, O75663Similarity: Belongs to the TIP41 family |
Function
for TIPRL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TIPRL_HUMAN, O75663Function: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalyticactivity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May playa role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPRL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPRL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TIPRL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPRL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPRL |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TIPRL for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TIPRL:
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Pathways & Interactions
for TIPRL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIPRL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/44 Interacting proteins for TIPRL (O756631, 3 ENSP000003568074) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TIPRL for ontologies About GeneDecksing
|
Drugs & Compounds
for TIPRL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TIPRL
Search CenterWatch for drugs/clinical trials and news about TIPRL
|
Transcripts
for TIPRL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TIPRL gene (2 alternative transcripts): NM_001031800.1 NM_152902.3 Unigene Cluster for TIPRL: TIP41, TOR signaling pathway regulator-like (S. cerevisiae) Hs.209431 [show with all ESTs]Unigene Representative Sequence: BX6486462 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367833(uc001gfg.3) ENST00000367830(uc001gff.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPRL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPRL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TIPRL (NM_152902) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIPRL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPRL |
Additional cDNA sequence: AB097034.1 AK313520.1 AL049670.1 BC009506.2 BX648646.1 6 DOTS entries: DT.100814295 DT.86821104 DT.100814296 DT.100814293 DT.100800183 DT.40315659 24/85 AceView cDNA sequences (see all 85): BI388668 BX098938 AW104302 CB107615 AL556260 BQ431241 BE296032 BC009506 CR624002 AL049670 BQ423852 AI348529 AL710858 CR608456 BG496854 BI254385 BX431957 BX645150 BI335234 AI983505 BU507379 BI915476 NM_152902 BX352956
GeneLoc Exon Structure
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Expression
for TIPRL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIPRL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATGGTTT
About this image
See TIPRL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIPRL
SOURCE GeneReport for Unigene cluster: Hs.209431
SABiosciences Custom PCR Arrays for TIPRL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIPRL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIPRL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIPRL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIPRL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPRL |
Orthologs
for TIPRL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for TIPRL gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for TIPRL (if available)
TreeFam Gene Tree for TIPRL (if available) |
Paralogs
for TIPRL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TIPRL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TIPRL (168148171 - 168171352 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TIPRL
5 CNVs: 84642 6794 74771 84643 74770 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIPRL |
|
Disorders
/ Diseases
for TIPRL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TIPRL for disorders About GeneDecksing
OMIM gene information: 611807
OMIM disorders: --
6  diseases for TIPRL: About MalaCardsessential hypertension hermaphroditism hypertension t-cell leukemia
leukemia carcinoma
Human Genome Epidemiology (HuGE) Navigator: TIPRL (2 documents)
Export disorders for TIPRL gene to outside databases
|
Publications
for TIPRL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIPRL gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with TIPRL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2, 3 Matsuda A....Sugano S. (2003)
- Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. (PubMed id 17384681)1, 2 McConnell J.L.... Wadzinski B.E. (2007)
- A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PubMed id 16085932)1, 2 Gingras A.-C.... Aebersold R. (2005)
- Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL). (PubMed id 17944932)2, 9 Smetana J.H. and Zanchin N.I. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Inhibition of MKK7-JNK by the TOR signaling pathway re gulator-like protein contributes to resistance of HCC cells to TRAIL-induced apo ptosis. (PubMed id 22841785)1 Song I.S....Kim N.S. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for TIPRL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TIPRL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIPRL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIPRL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TIPRL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TIPRL gene:
Search GeneIP for patents involving TIPRL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIPRL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TIPRL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIPRL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIPRL | | | OriGene Protein Over-expression Lysate for TIPRL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TIPRL | | OriGene 3'-UTR Clone for TIPRL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPRL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPRL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TIPRL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | TIPRL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPRL |
|  |  |  | | | | ThermoFisher Antibodies for TIPRL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPRL |
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