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Aliases for TIPRL Gene

Aliases for TIPRL Gene

  • TOR Signaling Pathway Regulator 2 3
  • Putative MAPK-Activating Protein PM10 3 4
  • Type 2A-Interacting Protein 3 4
  • TIP 3 4
  • TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae) 2
  • TIP41, TOR Signaling Pathway Regulator-Like 3
  • TIP41 3

External Ids for TIPRL Gene

Previous GeneCards Identifiers for TIPRL Gene

  • GC01P164880
  • GC01P166414
  • GC01P139392

Summaries for TIPRL Gene

Entrez Gene Summary for TIPRL Gene

  • TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

GeneCards Summary for TIPRL Gene

TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIPRL Gene

  • May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPRL Gene

Genomics for TIPRL Gene

Regulatory Elements for TIPRL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIPRL Gene

Chromosome:
1
Start:
168,178,845 bp from pter
End:
168,202,114 bp from pter
Size:
23,270 bases
Orientation:
Plus strand

Genomic View for TIPRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIPRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPRL Gene

Proteins for TIPRL Gene

  • Protein details for TIPRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75663-TIPRL_HUMAN
    Recommended name:
    TIP41-like protein
    Protein Accession:
    O75663
    Secondary Accessions:
    • B2R8V3
    • Q5HYB2
    • Q8IZ86

    Protein attributes for TIPRL Gene

    Size:
    272 amino acids
    Molecular mass:
    31444 Da
    Quaternary structure:
    • Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex.

    Alternative splice isoforms for TIPRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIPRL Gene

Proteomics data for TIPRL Gene at MOPED

Post-translational modifications for TIPRL Gene

  • Ubiquitination at Lys 84, Lys 106, Lys 117, Lys 128, Lys 207, and Lys 267
  • Modification sites at PhosphoSitePlus

Other Protein References for TIPRL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TIPRL Gene

Domains & Families for TIPRL Gene

Protein Domains for TIPRL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIPRL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75663

UniProtKB/Swiss-Prot:

TIPRL_HUMAN :
  • Belongs to the TIP41 family.
Family:
  • Belongs to the TIP41 family.
genes like me logo Genes that share domains with TIPRL: view

No data available for Gene Families for TIPRL Gene

Function for TIPRL Gene

Molecular function for TIPRL Gene

UniProtKB/Swiss-Prot Function:
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Gene Ontology (GO) - Molecular Function for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085932
genes like me logo Genes that share ontologies with TIPRL: view
genes like me logo Genes that share phenotypes with TIPRL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TIPRL Gene

Localization for TIPRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIPRL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIPRL Gene COMPARTMENTS Subcellular localization image for TIPRL gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TIPRL: view

Pathways & Interactions for TIPRL Gene

SuperPathways for TIPRL Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 17384681
GO:0034048 negative regulation of protein phosphatase type 2A activity IDA 17384681
genes like me logo Genes that share ontologies with TIPRL: view

No data available for Pathways by source and SIGNOR curated interactions for TIPRL Gene

Drugs & Compounds for TIPRL Gene

No Compound Related Data Available

Transcripts for TIPRL Gene

Unigene Clusters for TIPRL Gene

TIP41, TOR signaling pathway regulator-like (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIPRL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIPRL Gene

No ASD Table

Relevant External Links for TIPRL Gene

GeneLoc Exon Structure for
TIPRL
ECgene alternative splicing isoforms for
TIPRL

Expression for TIPRL Gene

mRNA expression in normal human tissues for TIPRL Gene

Protein differential expression in normal tissues from HIPED for TIPRL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIPRL Gene



SOURCE GeneReport for Unigene cluster for TIPRL Gene Hs.209431

genes like me logo Genes that share expression patterns with TIPRL: view

Protein tissue co-expression partners for TIPRL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIPRL Gene

Orthologs for TIPRL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIPRL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIPRL 35
  • 93.98 (n)
  • 96.64 (a)
TIPRL 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIPRL 35
  • 94.24 (n)
  • 96.32 (a)
TIPRL 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tiprl 35
  • 90.8 (n)
  • 97.01 (a)
Tiprl 16
Tiprl 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIPRL 35
  • 99.75 (n)
  • 100 (a)
TIPRL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tiprl 35
  • 90.92 (n)
  • 96.64 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TIPRL 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPRL 35
  • 77.28 (n)
  • 82.4 (a)
TIPRL 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPRL 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiprl 35
  • 72.24 (n)
  • 79.38 (a)
zebrafish
(Danio rerio)
Actinopterygii tiprl 35
  • 65.4 (n)
  • 67.3 (a)
zgc66327 35
tiprl 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002657 35
  • 52.91 (n)
  • 51.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9578 35
  • 48.09 (n)
  • 45.11 (a)
CG9578 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK688.9 35
  • 49.24 (n)
  • 41.91 (a)
ZK688.9 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR174C 35
  • 47.41 (n)
  • 37.07 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06139g 35
  • 47.19 (n)
  • 36.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIP41 35
  • 50.28 (n)
  • 39.41 (a)
TIP41 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34270 35
  • 50.91 (n)
  • 42.62 (a)
rice
(Oryza sativa)
Liliopsida Os03g0760600 35
  • 52.42 (n)
  • 41.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00109 35
  • 51.35 (n)
  • 44.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1543 36
  • 47 (a)
OneToOne
Species with no ortholog for TIPRL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIPRL Gene

ENSEMBL:
Gene Tree for TIPRL (if available)
TreeFam:
Gene Tree for TIPRL (if available)

Paralogs for TIPRL Gene

No data available for Paralogs for TIPRL Gene

Variants for TIPRL Gene

Sequence variations from dbSNP and Humsavar for TIPRL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1040403 -- 168,194,959(-) gattt(A/C)tcttg intron-variant
rs1040404 -- 168,190,652(-) CCACA(C/T)CTAAT intron-variant
rs1054720 -- 168,201,886(+) GAATT(C/G)ATTGT utr-variant-3-prime
rs1054721 -- 168,202,077(+) TTTTT(G/T)TAAGA utr-variant-3-prime
rs1320992 -- 168,185,216(+) TAGCT(C/T)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIPRL Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV Loss 17666407
nsv872526 CNV Gain 21882294

Variation tolerance for TIPRL Gene

Residual Variation Intolerance Score: 32.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIPRL Gene

HapMap Linkage Disequilibrium report
TIPRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPRL Gene

Disorders for TIPRL Gene

Relevant External Links for TIPRL

Genetic Association Database (GAD)
TIPRL
Human Genome Epidemiology (HuGE) Navigator
TIPRL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIPRL
genes like me logo Genes that share disorders with TIPRL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIPRL Gene

Publications for TIPRL Gene

  1. Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL). (PMID: 17944932) Smetana J.H. … Zanchin N.I. (FEBS J. 2007) 23 67
  2. Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses. (PMID: 16823088) Ayensu W.K. … Tchounwou P.B. (Int J Environ Res Public Health 2006) 23 67
  3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for TIPRL Gene

Sources for TIPRL Gene

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