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TIPRL Gene

protein-coding   GIFtS: 51
GCID: GC01P168148

TOR Signaling Pathway Regulator

(Previous names: TIP41, TOR signaling pathway regulator-like (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TOR Signaling Pathway Regulator1 2     TIP412 5
TIP2 3 5     TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae)1
Putative MAPK-Activating Protein PM102 3     TIP41, TOR Signaling Pathway Regulator-Like2
Type 2A-Interacting Protein2 3     TIP41-Like Protein2

External Ids:    HGNC: 302311   Entrez Gene: 2617262   Ensembl: ENSG000001431557   OMIM: 6118075   UniProtKB: O756633   

Export aliases for TIPRL gene to outside databases

Previous GC identifers: GC01P164880 GC01P166414 GC01P139392


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIPRL Gene:
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM
602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 (PubMed 17384681)).(supplied by OMIM, Nov 2010)

GeneCards Summary for TIPRL Gene:
TIPRL (TOR signaling pathway regulator) is a protein-coding gene.

UniProtKB/Swiss-Prot: TIPRL_HUMAN, O75663
Function: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits
catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase
activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIPRL gene promoter:
         Pbx1a   Nkx2-5   AP-2gamma   Cdc5   Evi-1   FOXJ2 (long isoform)   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIPRL promoter sequence
   Search Chromatin IP Primers for TIPRL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIPRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q23.2

TIPRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIPRL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P168148:  view genomic region     (about GC identifiers)

Start:
168,148,171 bp from pter      End:
168,171,352 bp from pter
Size:
23,182 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIPRL_HUMAN, O75663 (See protein sequence)
Recommended Name: TIP41-like protein  
Size: 272 amino acids; 31444 Da
Subunit: Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C
and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A
PP2A(C):alpha-4 complex
Secondary accessions: B2R8V3 Q5HYB2 Q8IZ86
Alternative splicing: 2 isoforms:  O75663-1   O75663-2   

Explore the universe of human proteins at neXtProt for TIPRL: NX_O75663

Explore proteomics data for TIPRL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys84, Lys106, Lys117, Lys128, Lys207, Lys267
  • Modification sites at PhosphoSitePlus

  • See TIPRL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026970.1  NP_690866.1  

    ENSEMBL proteins: 
     ENSP00000356807   ENSP00000356804  

    TIPRL Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007303 TIP41-like

    Graphical View of Domain Structure for InterPro Entry O75663

    ProtoNet protein and cluster: O75663

    UniProtKB/Swiss-Prot: TIPRL_HUMAN, O75663
    Similarity: Belongs to the TIP41 family


    Find genes that share domains with TIPRL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIPRL_HUMAN, O75663
    Function: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits
    catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase
    activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16085932
         
    Find genes that share ontologies with TIPRL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TIPRL:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIPRL
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    miRNA
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    miRTarBase miRNAs that target TIPRL:
    hsa-mir-29c-3p (MIRT020368), hsa-mir-26b-5p (MIRT029223)

    Block miRNA regulation of human, mouse, rat TIPRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIPRL (see all 18):
    hsa-miR-520d-5p hsa-miR-548v hsa-miR-10b* hsa-miR-515-5p hsa-miR-641 hsa-miR-3908 hsa-miR-548x hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTIPRL 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIPRL_HUMAN, O75663: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with TIPRL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIPRL
    Interactions:

        Search GeneGlobe Interaction Network for TIPRL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIPRL (O756631, 2, 3 ENSP000003568074) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677751, 2, 3EBI-1054735,EBI-712311 MINT-8434742 MINT-8434751 I2D: score=5 
    IGBP1P783181, 2, ENSP000003487844EBI-1054735,EBI-1055954 MINT-8434844 MINT-8434835 STRING: ENSP00000348784
    PPP6CO007431, 3, ENSP000003921474EBI-1054735,EBI-359751 I2D: score=3 STRING: ENSP00000392147
    PPP4CP605101, 3, ENSP000002793874EBI-1054735,EBI-1046072 I2D: score=2 STRING: ENSP00000279387
    PSMD12O002323, ENSP000003484424I2D: score=3 STRING: ENSP00000348442
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP17384681
    GO:0034048negative regulation of protein phosphatase type 2A activity IDA17384681

    Find genes that share ontologies with TIPRL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIPRL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIPRL gene (2 alternative transcripts): 
    NM_001031800.2  NM_152902.4  

    Unigene Cluster for TIPRL:

    TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
    Hs.209431  [show with all ESTs]
    Unigene Representative Sequence: BX648646
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367833(uc001gfg.3) ENST00000367830(uc001gff.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat TIPRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIPRL (see all 18):
    hsa-miR-520d-5p hsa-miR-548v hsa-miR-10b* hsa-miR-515-5p hsa-miR-641 hsa-miR-3908 hsa-miR-548x hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTIPRL 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TIPRL
      QuantiFast Probe-based Assays in human, mouse, rat TIPRL

    Additional mRNA sequence: 

    AB097034.1 AK313520.1 AL049670.1 BC009506.2 BX648646.1 

    6 DOTS entries:

    DT.100814295  DT.86821104  DT.100814296  DT.100800183  DT.100814293  DT.40315659 

    Selected AceView cDNA sequences (see all 85):

    CR624002 BE296032 BX098938 BQ431241 BC009506 BQ423852 AW104302 AL556260 
    AL049670 AI348529 AL710858 CB107615 BI388668 CR608456 BU507379 BM684620 
    BM931050 BM931171 BI335234 AI278082 BI915210 BX645150 AA452219 BX648646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIPRL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATGGTTT
    TIPRL Expression
    About this image

    TIPRL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIPRL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.209431
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TIPRL gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tiprl1 , 5 TIP41, TOR signalling pathway regulator-like (S. cerevisiae)1, 5 90.8(n)1
    97.01(a)1
      1 (72.55 cM)5
    2265911  NM_145513.41  NP_663488.11 
     1652149225 
    chicken
    (Gallus gallus)
    Aves TIPRL1 TIP41, TOR signaling pathway regulator-like (S. cerevisiae) 77.28(n)
    82.4(a)
      418374  XM_416593.4  XP_416593.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIPRL6
    TIP41, TOR signaling pathway regulator-like (S. ce...
    79(a)
    1 ↔ 1
    3(175089188-175096042)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG731521.12   -- 72.07(n)    BG731521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663272 hypothetical protein MGC66327 70.18(n)   393636  BC057515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95781 CG9578 48.09(n)
    45.11(a)
      33018  NM_134533.3  NP_608377.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK688.91 ZK688.9 49.24(n)
    41.91(a)
      176106  NM_066312.5  NP_498713.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIP411 TIP41 50.28(n)
    39.41(a)
      856153   NP_015365.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G342701 AT4G34270 50.91(n)
    42.62(a)
      829577  NM_119592.4  NP_195153.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07606001 Os03g0760600 52.42(n)
    41.03(a)
      4334187  NM_001057881.1  NP_001051346.1 


    ENSEMBL Gene Tree for TIPRL (if available)
    TreeFam Gene Tree for TIPRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIPRL (see all 537)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114935161,2
    C,F--168146178(+) GCACTC/TTGGGA 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1427047331,2
    C--168146335(+) GAATCA/GCTTGA 2 -- us2k10--------
    rs1846263761,2
    --168146369(+) GAACCA/GAGATG 2 -- us2k10--------
    rs120711581,2
    C,A--168146424(+) caaaaA/Caaaac 2 -- us2k10--------
    rs2015404741,2
    --168146424(+) CAAAA-/CAAAAC 2 -- us2k10--------
    rs120968391,2
    C--168146428(+) acaaaC/Acaaaa 2 -- us2k13Minor allele frequency- A:0.20WA NA CSA 5
    rs715724931,2
    C--168146429(+) AAAACC/-AAAAC 2 -- us2k12Minor allele frequency- -:0.25NA CSA 4
    rs1163022651,2
    C,F--168146455(+) AACTAT/AGGCCA 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1445678951,2
    --168146505(+) ATGTCA/GTTAAA 2 -- us2k10--------
    rs1891891811,2
    C--168146551(+) TTTCCA/CACCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TIPRL (168148171 - 168171352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TIPRL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv32660CNV Loss17666407
    nsv872526CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIPRL
    DNA2.0 Custom Variant and Variant Library Synthesis for TIPRL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611807    OMIM disorders: --


    Find genes that share disorders with TIPRL           About GenesLikeMe

    Genetic Association Database (GAD): TIPRL
    Human Genome Epidemiology (HuGE) Navigator: TIPRL (2 documents)

    Export disorders for TIPRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIPRL gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with TIPRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2, 3 Matsuda A....Sugano S. (Oncogene 2003)
    2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    3. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    4. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. (PubMed id 17384681)1, 2 McConnell J.L.... Wadzinski B.E. (Oncogene 2007)
    5. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PubMed id 16085932)1, 2 Gingras A.-C.... Aebersold R. (Mol. Cell. Proteomics 2005)
    6. Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL). (PubMed id 17944932)2, 9 Smetana J.H. and Zanchin N.I. (FEBS J. 2007)
    7. A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A. (PubMed id 23892082)1 Nakashima A....Kikkawa U. (FEBS Lett. 2013)
    8. The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity. (PubMed id 22443683)1 Sents W....Janssens V. (FEBS J. 2013)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 261726 HGNC: 30231 AceView: MGC3794 Ensembl:ENSG00000143155 euGenes: HUgn261726
    ECgene: TIPRL H-InvDB: TIPRL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIPRL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIPRL gene:
    Search GeneIP for patents involving TIPRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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