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Aliases for TIPRL Gene

Aliases for TIPRL Gene

  • TOR Signaling Pathway Regulator 2 3
  • TIP 3 4 6
  • Putative MAPK-Activating Protein PM10 3 4
  • Type 2A-Interacting Protein 3 4
  • TIP41 3 6
  • TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae) 2
  • TIP41, TOR Signaling Pathway Regulator-Like 3
  • TIP41-Like Protein 3

External Ids for TIPRL Gene

Previous GeneCards Identifiers for TIPRL Gene

  • GC01P164880
  • GC01P166414
  • GC01P139392

Summaries for TIPRL Gene

Entrez Gene Summary for TIPRL Gene

  • TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

GeneCards Summary for TIPRL Gene

TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIPRL Gene

  • May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPRL Gene

Genomics for TIPRL Gene

Regulatory Elements for TIPRL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIPRL Gene

Start:
168,178,845 bp from pter
End:
168,202,114 bp from pter
Size:
23,270 bases
Orientation:
Plus strand

Genomic View for TIPRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIPRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPRL Gene

Proteins for TIPRL Gene

  • Protein details for TIPRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75663-TIPRL_HUMAN
    Recommended name:
    TIP41-like protein
    Protein Accession:
    O75663
    Secondary Accessions:
    • B2R8V3
    • Q5HYB2
    • Q8IZ86

    Protein attributes for TIPRL Gene

    Size:
    272 amino acids
    Molecular mass:
    31444 Da
    Quaternary structure:
    • Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex.

    Alternative splice isoforms for TIPRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIPRL Gene

Proteomics data for TIPRL Gene at MOPED

Post-translational modifications for TIPRL Gene

  • Ubiquitination at Lys84, Lys106, Lys117, Lys128, Lys207, and Lys267
  • Modification sites at PhosphoSitePlus

Other Protein References for TIPRL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIPRL Gene

Domains for TIPRL Gene

Protein Domains for TIPRL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIPRL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75663

UniProtKB/Swiss-Prot:

TIPRL_HUMAN :
  • O75663
Family:
  • Belongs to the TIP41 family.
genes like me logo Genes that share domains with TIPRL: view

No data available for Gene Families for TIPRL Gene

Function for TIPRL Gene

Molecular function for TIPRL Gene

UniProtKB/Swiss-Prot Function: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Gene Ontology (GO) - Molecular Function for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085932
genes like me logo Genes that share ontologies with TIPRL: view

Phenotypes for TIPRL Gene

GenomeRNAi human phenotypes for TIPRL:
genes like me logo Genes that share phenotypes with TIPRL: view

Animal Model Products

CRISPR Products

miRNA for TIPRL Gene

miRTarBase miRNAs that target TIPRL

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIPRL Gene

Localization for TIPRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIPRL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIPRL Gene COMPARTMENTS Subcellular localization image for TIPRL gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TIPRL: view

Pathways for TIPRL Gene

SuperPathways for TIPRL Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 17384681
GO:0034048 negative regulation of protein phosphatase type 2A activity IDA 17384681
genes like me logo Genes that share ontologies with TIPRL: view

No data available for Pathways by source for TIPRL Gene

Transcripts for TIPRL Gene

Unigene Clusters for TIPRL Gene

TIP41, TOR signaling pathway regulator-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIPRL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIPRL Gene

No ASD Table

Relevant External Links for TIPRL Gene

GeneLoc Exon Structure for
TIPRL
ECgene alternative splicing isoforms for
TIPRL

Expression for TIPRL Gene

mRNA expression in normal human tissues for TIPRL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIPRL Gene

SOURCE GeneReport for Unigene cluster for TIPRL Gene Hs.209431

genes like me logo Genes that share expressions with TIPRL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIPRL Gene

Orthologs for TIPRL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIPRL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPRL 35
  • 99.75 (n)
  • 100 (a)
TIPRL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIPRL 35
  • 93.98 (n)
  • 96.64 (a)
TIPRL 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIPRL 35
  • 94.24 (n)
  • 96.32 (a)
TIPRL 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tiprl 35
  • 90.8 (n)
  • 97.01 (a)
Tiprl 16
Tiprl 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TIPRL 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tiprl 35
  • 90.92 (n)
  • 96.64 (a)
chicken
(Gallus gallus)
Aves TIPRL 35
  • 77.28 (n)
  • 82.4 (a)
TIPRL 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPRL 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiprl 35
  • 72.24 (n)
  • 79.38 (a)
zebrafish
(Danio rerio)
Actinopterygii tiprl 35
  • 65.4 (n)
  • 67.3 (a)
tiprl 36
  • 64 (a)
OneToOne
zgc66327 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002657 35
  • 52.91 (n)
  • 51.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9578 35
  • 48.09 (n)
  • 45.11 (a)
CG9578 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK688.9 35
  • 49.24 (n)
  • 41.91 (a)
ZK688.9 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR174C 35
  • 47.41 (n)
  • 37.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIP41 35
  • 50.28 (n)
  • 39.41 (a)
TIP41 36
  • 26 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06139g 35
  • 47.19 (n)
  • 36.63 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34270 35
  • 50.91 (n)
  • 42.62 (a)
rice
(Oryza sativa)
Liliopsida Os03g0760600 35
  • 52.42 (n)
  • 41.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00109 35
  • 51.35 (n)
  • 44.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1543 36
  • 47 (a)
OneToOne
Species with no ortholog for TIPRL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIPRL Gene

ENSEMBL:
Gene Tree for TIPRL (if available)
TreeFam:
Gene Tree for TIPRL (if available)

Paralogs for TIPRL Gene

No data available for Paralogs for TIPRL Gene

Variants for TIPRL Gene

Sequence variations from dbSNP and Humsavar for TIPRL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1040403 -- 168,194,959(-) gattt(A/C)tcttg intron-variant
rs1040404 -- 168,190,652(-) CCACA(C/T)CTAAT intron-variant
rs1054720 -- 168,201,886(+) GAATT(C/G)ATTGT utr-variant-3-prime
rs1054721 -- 168,202,077(+) TTTTT(G/T)TAAGA utr-variant-3-prime
rs1320992 -- 168,185,216(+) TAGCT(C/T)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIPRL Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV Loss 17666407
nsv872526 CNV Gain 21882294

Relevant External Links for TIPRL Gene

HapMap Linkage Disequilibrium report
TIPRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPRL Gene

Disorders for TIPRL Gene

Relevant External Links for TIPRL

Genetic Association Database (GAD)
TIPRL
Human Genome Epidemiology (HuGE) Navigator
TIPRL
genes like me logo Genes that share disorders with TIPRL: view

No data available for UniProtKB/Swiss-Prot for TIPRL Gene

Publications for TIPRL Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 3 4
  2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras A.-C. … Aebersold R. (Mol. Cell. Proteomics 2005) 3 4
  3. Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL). (PMID: 17944932) Smetana J.H. … Zanchin N.I. (FEBS J. 2007) 4 23
  4. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. (PMID: 17384681) McConnell J.L. … Wadzinski B.E. (Oncogene 2007) 3 4
  5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 48

Products for TIPRL Gene

Sources for TIPRL Gene

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