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Aliases for TIPIN Gene

Aliases for TIPIN Gene

  • TIMELESS Interacting Protein 2 3
  • CSM3 Homolog (S. Cerevisiae) 2

External Ids for TIPIN Gene

Previous GeneCards Identifiers for TIPIN Gene

  • GC15M064417
  • GC15M066629
  • GC15M043465

Summaries for TIPIN Gene

Entrez Gene Summary for TIPIN Gene

  • The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TIPIN Gene

TIPIN (TIMELESS Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIPIN Gene

  • Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.

Gene Wiki entry for TIPIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPIN Gene

Genomics for TIPIN Gene

Regulatory Elements for TIPIN Gene

Genomic Location for TIPIN Gene

Start:
66,336,206 bp from pter
End:
66,386,746 bp from pter
Size:
50,541 bases
Orientation:
Minus strand

Genomic View for TIPIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIPIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPIN Gene

Proteins for TIPIN Gene

  • Protein details for TIPIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVW5-TIPIN_HUMAN
    Recommended name:
    TIMELESS-interacting protein
    Protein Accession:
    Q9BVW5
    Secondary Accessions:
    • B2CW64
    • Q9NWZ6

    Protein attributes for TIPIN Gene

    Size:
    301 amino acids
    Molecular mass:
    34555 Da
    Quaternary structure:
    • Interacts with TIMELESS, which impairs TIMELESS self-association. Interacts with RPA2, PRDX2, MCM6 and MCM7.

neXtProt entry for TIPIN Gene

Proteomics data for TIPIN Gene at MOPED

Post-translational modifications for TIPIN Gene

  • Ubiquitination at Lys101 and Lys117
  • Modification sites at PhosphoSitePlus

Other Protein References for TIPIN Gene

Antibody Products

No data available for DME Specific Peptides for TIPIN Gene

Domains for TIPIN Gene

Protein Domains for TIPIN Gene

Suggested Antigen Peptide Sequences for TIPIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVW5

UniProtKB/Swiss-Prot:

TIPIN_HUMAN :
  • Q9BVW5
Family:
  • Belongs to the CSM3 family.
genes like me logo Genes that share domains with TIPIN: view

No data available for Gene Families for TIPIN Gene

Function for TIPIN Gene

Molecular function for TIPIN Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.

Gene Ontology (GO) - Molecular Function for TIPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17102137
genes like me logo Genes that share ontologies with TIPIN: view

Phenotypes for TIPIN Gene

genes like me logo Genes that share phenotypes with TIPIN: view

Animal Model Products

miRNA for TIPIN Gene

miRTarBase miRNAs that target TIPIN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIPIN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIPIN Gene

Localization for TIPIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIPIN Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIPIN Gene COMPARTMENTS Subcellular localization image for TIPIN gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for TIPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 17102137
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TIPIN: view

Pathways for TIPIN Gene

SuperPathways for TIPIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint IMP 17102137
GO:0000077 DNA damage checkpoint --
GO:0006974 cellular response to DNA damage stimulus --
GO:0007049 cell cycle --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with TIPIN: view

No data available for Pathways by source for TIPIN Gene

Transcripts for TIPIN Gene

Unigene Clusters for TIPIN Gene

TIMELESS interacting protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIPIN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIPIN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -

Relevant External Links for TIPIN Gene

GeneLoc Exon Structure for
TIPIN
ECgene alternative splicing isoforms for
TIPIN

Expression for TIPIN Gene

mRNA expression in normal human tissues for TIPIN Gene

Protein differential expression in normal tissues for TIPIN Gene

This gene is overexpressed in Urine (65.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIPIN Gene

SOURCE GeneReport for Unigene cluster for TIPIN Gene Hs.744308

genes like me logo Genes that share expressions with TIPIN: view

Expression partners for TIPIN Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIPIN Gene

Orthologs for TIPIN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIPIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIPIN 35
  • 87.87 (n)
  • 82.69 (a)
TIPIN 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIPIN 35
  • 85.92 (n)
  • 81.08 (a)
TIPIN 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tipin 35
  • 82 (n)
  • 77.17 (a)
Tipin 16
Tipin 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIPIN 35
  • 98.78 (n)
  • 98.34 (a)
TIPIN 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIPIN 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIPIN 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPIN 35
  • 69.62 (n)
  • 64.16 (a)
TIPIN 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPIN 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tipin 35
  • 63.17 (n)
  • 61.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8214 35
zebrafish
(Danio rerio)
Actinopterygii tipin 35
  • 63.3 (n)
  • 63.94 (a)
tipin 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10336 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSM3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3163 36
  • 38 (a)
OneToOne
Species with no ortholog for TIPIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIPIN Gene

ENSEMBL:
Gene Tree for TIPIN (if available)
TreeFam:
Gene Tree for TIPIN (if available)

Paralogs for TIPIN Gene

Pseudogenes.org Pseudogenes for TIPIN Gene

genes like me logo Genes that share paralogs with TIPIN: view

No data available for Paralogs for TIPIN Gene

Variants for TIPIN Gene

Sequence variations from dbSNP and Humsavar for TIPIN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2918 -- 66,378,604(+) GCCTT(A/T)ATGGT intron-variant
rs1978698 -- 66,374,191(-) CTGGA(A/G)GCTAA intron-variant
rs1978699 -- 66,373,885(-) tctct(A/G)caaaa intron-variant
rs2063690 - 66,349,394(-) CTGGG(C/G)ACATA reference, missense
rs2414902 -- 66,344,180(-) tttga(A/G)gctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIPIN Gene

Variant ID Type Subtype PubMed ID
nsv833045 CNV Gain 17160897
esv2552740 CNV Deletion 19546169
esv2223439 CNV Deletion 18987734
esv2749790 CNV Deletion 23290073
esv5372 CNV Deletion 18987735
esv6981 CNV Loss 19470904
esv1418932 CNV Deletion 17803354
esv1006740 CNV Deletion 20482838
esv2590993 CNV Deletion 19546169

Relevant External Links for TIPIN Gene

HapMap Linkage Disequilibrium report
TIPIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPIN Gene

Disorders for TIPIN Gene

Relevant External Links for TIPIN

Genetic Association Database (GAD)
TIPIN
Human Genome Epidemiology (HuGE) Navigator
TIPIN

No disorders were found for TIPIN Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TIPIN Gene

Publications for TIPIN Gene

  1. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. (PMID: 17102137) Yoshizawa-Sugata N. … Masai H. (J. Biol. Chem. 2007) 2 3 4 23
  2. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. (PMID: 17116885) Chou D.M. … Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  3. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. (PMID: 17296725) Uensal-Kacmaz K. … Kaufmann W.K. (Mol. Cell. Biol. 2007) 3 4 23
  4. Tipin, a novel timeless-interacting protein, is developmentally co- expressed with timeless and disrupts its self-association. (PMID: 12875843) Gotter A.L. (J. Mol. Biol. 2003) 2 3 4
  5. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. (PMID: 17141802) Gotter A.L. … Emanuel B.S. (J. Mol. Biol. 2007) 3 4

Products for TIPIN Gene

Sources for TIPIN Gene

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