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Aliases for TIPARP Gene

Aliases for TIPARP Gene

  • TCDD Inducible Poly(ADP-Ribose) Polymerase 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 14 3 4
  • Poly [ADP-Ribose] Polymerase 7 3 4
  • ARTD14 3 4
  • PARP7 3 4
  • TCDD-Inducible Poly [ADP-Ribose] Polymerase 3
  • TCDD-Inducible Poly(ADP-Ribose) Polymerase 2
  • EC 2.4.2.30 4
  • PART14 3
  • PARP-7 4

External Ids for TIPARP Gene

Previous GeneCards Identifiers for TIPARP Gene

  • GC03P157713
  • GC03P157875
  • GC03P156391
  • GC03P153788

Summaries for TIPARP Gene

Entrez Gene Summary for TIPARP Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for TIPARP Gene

TIPARP (TCDD Inducible Poly(ADP-Ribose) Polymerase) is a Protein Coding gene. Diseases associated with TIPARP include Male Reproductive Organ Cancer. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enhancer binding. An important paralog of this gene is PARP12.

UniProtKB/Swiss-Prot for TIPARP Gene

  • Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Gene Wiki entry for TIPARP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPARP Gene

Genomics for TIPARP Gene

Regulatory Elements for TIPARP Gene

Enhancers for TIPARP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F157063 1.6 FANTOM5 Ensembl ENCODE 26 +391.2 391211 1.1 HDGF ATF1 ZNF766 GATA2 FOS JUNB NCOA1 TBX21 SREBF1 CREB3 TIPARP LEKR1 TIPARP-AS1 SSR3 LINC00886 CCNL1 LINC02029 RN7SKP177
GH03F156642 1.4 FANTOM5 Ensembl ENCODE 18.1 -29.5 -29507 2.1 HDGF HDAC1 TBL1XR1 ZBTB40 ETV6 CREM CBFB JUNB ELF1 TBX21 TIPARP TIPARP-AS1 LINC00886 LEKR1 GC03P156555
GH03F157124 2 VISTA FANTOM5 Ensembl ENCODE 11.1 +458.2 458214 13.5 HDGF PKNOX1 MLX ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 KRT18P34 CCNL1 LEKR1 LINC00880 ENSG00000241770 TIPARP SSR3 TIPARP-AS1 GC03M157131
GH03F157077 1.5 FANTOM5 Ensembl ENCODE 11.5 +404.5 404487 1.4 ELF3 ATF1 PTRF DMAP1 ZNF48 RAD21 RARA CREM MIXL1 NFYC TIPARP TIPARP-AS1 KCNAB1-AS1 SSR3 LINC00886 PQLC2L LINC02029 RN7SKP177
GH03F157085 1.4 FANTOM5 ENCODE 11.6 +415.5 415459 6.2 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCNL1 TIPARP TIPARP-AS1 ENSG00000241770 KRT18P34 SSR3 KCNAB1-AS1 LINC00881 LINC02029
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIPARP on UCSC Golden Path with GeneCards custom track

Genomic Location for TIPARP Gene

Chromosome:
3
Start:
156,673,235 bp from pter
End:
156,706,770 bp from pter
Size:
33,536 bases
Orientation:
Plus strand

Genomic View for TIPARP Gene

Genes around TIPARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIPARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIPARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPARP Gene

Proteins for TIPARP Gene

  • Protein details for TIPARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E1-PARPT_HUMAN
    Recommended name:
    TCDD-inducible poly [ADP-ribose] polymerase
    Protein Accession:
    Q7Z3E1
    Secondary Accessions:
    • D3DNK6
    • Q68CY9
    • Q86VP4
    • Q9Y4P7

    Protein attributes for TIPARP Gene

    Size:
    657 amino acids
    Molecular mass:
    76227 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIPARP Gene

Post-translational modifications for TIPARP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIPARP Gene

Domains & Families for TIPARP Gene

Gene Families for TIPARP Gene

Protein Domains for TIPARP Gene

Suggested Antigen Peptide Sequences for TIPARP Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3E1

UniProtKB/Swiss-Prot:

PARPT_HUMAN :
  • Contains 1 PARP catalytic domain.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • Contains 1 PARP catalytic domain.
  • Contains 1 WWE domain.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with TIPARP: view

Function for TIPARP Gene

Molecular function for TIPARP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Enzyme Numbers (IUBMB) for TIPARP Gene

Gene Ontology (GO) - Molecular Function for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA 23275542
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0035326 enhancer binding IDA 23275542
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIPARP: view
genes like me logo Genes that share phenotypes with TIPARP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIPARP Gene

Localization for TIPARP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIPARP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23275542
genes like me logo Genes that share ontologies with TIPARP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TIPARP Gene

Pathways & Interactions for TIPARP Gene

SuperPathways for TIPARP Gene

No Data Available

Interacting Proteins for TIPARP Gene

Gene Ontology (GO) - Biological Process for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006471 protein ADP-ribosylation IEA --
GO:0006807 nitrogen compound metabolic process IEA --
GO:0008209 androgen metabolic process IEA --
genes like me logo Genes that share ontologies with TIPARP: view

No data available for Pathways by source and SIGNOR curated interactions for TIPARP Gene

Drugs & Compounds for TIPARP Gene

(2) Drugs for TIPARP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 902,906
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with TIPARP: view

Transcripts for TIPARP Gene

mRNA/cDNA for TIPARP Gene

Unigene Clusters for TIPARP Gene

TCDD-inducible poly(ADP-ribose) polymerase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIPARP Gene

No ASD Table

Relevant External Links for TIPARP Gene

GeneLoc Exon Structure for
TIPARP
ECgene alternative splicing isoforms for
TIPARP

Expression for TIPARP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIPARP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TIPARP Gene:

TIPARP

SOURCE GeneReport for Unigene cluster for TIPARP Gene:

Hs.744050
genes like me logo Genes that share expression patterns with TIPARP: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TIPARP Gene

Orthologs for TIPARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIPARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPARP 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TIPARP 34 35
  • 94.06 (n)
cow
(Bos Taurus)
Mammalia TIPARP 34 35
  • 92.99 (n)
mouse
(Mus musculus)
Mammalia Tiparp 34 16 35
  • 90.55 (n)
rat
(Rattus norvegicus)
Mammalia Tiparp 34
  • 90.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIPARP 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIPARP 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPARP 34 35
  • 72.7 (n)
lizard
(Anolis carolinensis)
Reptilia TIPARP 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiparp 34
  • 65.18 (n)
Str.10375 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9867 34
zebrafish
(Danio rerio)
Actinopterygii tiparp 34 35
  • 60.04 (n)
Species where no ortholog for TIPARP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIPARP Gene

ENSEMBL:
Gene Tree for TIPARP (if available)
TreeFam:
Gene Tree for TIPARP (if available)

Paralogs for TIPARP Gene

Paralogs for TIPARP Gene

(2) SIMAP similar genes for TIPARP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIPARP: view

Variants for TIPARP Gene

Sequence variations from dbSNP and Humsavar for TIPARP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10631452 -- 156,695,826(+) TTTCC(-/TTT)CTTTT intron-variant
rs111363283 -- 156,673,259(+) AACAA(C/T)CTAAT nc-transcript-variant, upstream-variant-2KB
rs111463909 -- 156,695,202(+) CAAAT(-/TTTA/TTTATTTA)TTTAT intron-variant
rs111558499 -- 156,678,045(+) ACAAA(C/T)GTTGG upstream-variant-2KB, reference, synonymous-codon
rs111663886 -- 156,678,555(+) TCTCA(G/T)GAGCA upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TIPARP Gene

Variant ID Type Subtype PubMed ID
nsv954498 CNV duplication 24416366

Variation tolerance for TIPARP Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIPARP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIPARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPARP Gene

Disorders for TIPARP Gene

MalaCards: The human disease database

(1) MalaCards diseases for TIPARP Gene - From: DISEASES

Disorder Aliases PubMed IDs
male reproductive organ cancer
  • male genital cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TIPARP

Genetic Association Database (GAD)
TIPARP
Human Genome Epidemiology (HuGE) Navigator
TIPARP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIPARP
genes like me logo Genes that share disorders with TIPARP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIPARP Gene

Publications for TIPARP Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 22 64
  2. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PMID: 20852632) Goode E.L. … Pharoah P.D. (Nat. Genet. 2010) 3 46 64
  3. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PMID: 18762178) de Waard P.W. … de Kok T.M. (Chem. Biol. Interact. 2008) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors. (PMID: 26814197) BindesbA … Matthews J. (Biochem. J. 2016) 3 64

Products for TIPARP Gene

Sources for TIPARP Gene

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