TIPARP Gene
protein-coding GIFtS: 54
GCID: GC03P156391
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TCDD-inducible poly(ADP-ribose) polymerase
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Aliases for TIPARP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| TCDD-Inducible Poly(ADP-Ribose) Polymerase1 2 | | DDF11 | | PARP71 2 3 | | DKFZP434J2141 | | PART141 | | DKFZp686N03511 | | PARP-71 3 | | PARP-11 | | Poly [ADP-Ribose] Polymerase 72 3 | | RM11 | | ARTD142 3 | | TCDD-Inducible Poly [ADP-Ribose] Polymerase2 | | ADP-Ribosyltransferase Diphtheria Toxin-Like 142 3 | | EC 2.4.2.303 |
Export aliases for TIPARP gene to outside databasesPrevious GC identifers: GC03P157713 GC03P157875 GC03P153788 |
Summaries for TIPARP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TIPARP: This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shownthat the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternativesplicing results in multiple transcript variants. (provided by RefSeq, May 2010) UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residuesof a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on theprotein, thereby altering the function of the target protein. May play a role in the adaptative response to chemicalexposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity) Gene Wiki entry for TIPARP
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Genomic Views for TIPARP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TIPARP gene promoter: TBP RORalpha2 Max GATA-6 POU2F1 POU2F1a STAT3 TGIF Other transcription factors
Search SABiosciences Chromatin IP Primers for TIPARP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIPARP |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25.31 Ensembl cytogenetic band: 3q25.31 HGNC cytogenetic band: 3q25.31TIPARP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P156391: view genomic region
(about GC identifiers)
Start:
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156,391,024 bp from pter |
End:
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156,424,559 bp from pter |
Size:
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33,536 bases |
Orientation:
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plus strand |
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Proteins for TIPARP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1 (See
protein sequence)Recommended Name: TCDD-inducible poly [ADP-ribose] polymerase Size: 657 amino acids; 76227 Da
Secondary accessions: D3DNK6 Q68CY9 Q86VP4 Q9Y4P7Explore the universe of human proteins at neXtProt for TIPARP: NX_Q7Z3E1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z3E1 TIPARP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001171646.1 NP_001171647.1 NP_056323.2 ENSEMBL proteins: ENSP00000418757 ENSP00000295924 ENSP00000420612 ENSP00000419982 ENSP00000418829 ENSP00000420141 ENSP00000438345 Human Recombinant Protein Products:
TIPARP Antibody Products: Assay Products for TIPARP: |
Protein
Domains / Families for TIPARP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIPARP for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z3E1ProtoNet protein and cluster: Q7Z3E1 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1Similarity: Contains 1 C3H1-type zinc fingerSimilarity: Contains 1 PARP catalytic domainSimilarity: Contains 1 WWE domain |
Function for TIPARP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residuesof a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on theprotein, thereby altering the function of the target protein. May play a role in the adaptative response to chemicalexposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity)Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptorEnzyme Number (IUBMB): EC 2.4.2.301
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TIPARP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
TIPARP for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TIPARP: Animal Models: 12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tiparp):
TIPARP for phenotypes About GeneDecksing
|
Pathways & Interactions for TIPARP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIPARP
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 4 Interacting proteins for TIPARP (Q7Z3E13 ENSP000002959244) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
TIPARP for ontologies About GeneDecksing
|
Drugs & Compounds for TIPARP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TIPARP
1 HMDB Compound for TIPARP About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- | Search CenterWatch for drugs/clinical trials and news about TIPARP / PARPT 
|
Transcripts for TIPARP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TIPARP gene (3 alternative transcripts): NM_001184717.1 NM_001184718.1 NM_015508.4 Unigene Cluster for TIPARP: TCDD-inducible poly(ADP-ribose) polymerase Hs.744050 [show with all ESTs]Unigene Representative Sequence: NM_0011847177 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486483 ENST00000295924(uc003fav.3) ENST00000461166(uc003faw.3) ENST00000473702 ENST00000481853 ENST00000495891 ENST00000542783(uc021xgg.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TIPARP (NM_015508) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIPARP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP  |
Additional cDNA sequence: AK097785.1 AK291261.1 AL080156.1 BC034397.1 BC050350.1 BX537965.1 CR749647.1 6 DOTS entries: DT.116445 DT.100711082 DT.100788936 DT.95119625 DT.92432570 DT.95162048 11 AceView cDNA sequences: BX091689 BC033324 BC038770 BI460811 BG191295 CB048085 BG210943 BG218862 BG720335 AA879405 BG201414 GeneLoc Exon Structure
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Expression for TIPARP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIPARP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAATGGCCAA
About this image See TIPARP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TIPARP
SOURCE GeneReport for Unigene cluster: Hs.744050 SABiosciences Custom PCR Arrays for TIPARP
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIPARP Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIPARP | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIPARP | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIPARP | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP |
Orthologs for TIPARP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TIPARP gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
TIPARP1 |
TCDD-inducible poly(ADP-ribose) polymerase |
72.43(n) 69.75(a) |
  |
425026 XM_422828.3 XP_422828.1 |
lizard (Anolis carolinensis) |
Reptilia |
TIPARP6 |
-- |
64(a) |
1 ↔ 1 |
3(15400899-15426897) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.98672 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.99(n) |
  |
48044178 |
zebrafish (Danio rerio) |
Actinopterygii |
tiparp1 |
TCDD-inducible poly(ADP-ribose) polymerase |
59.07(n) 56.54(a) |
  |
563506 NM_001045019.3 NP_001038484.1 |
ENSEMBL Gene Tree for TIPARP (if available) TreeFam Gene Tree for TIPARP (if available)  |
Paralogs for TIPARP gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TIPARP gene
- PARP152 PARP112 PARP92 PARP102 PARP142 PARP122 ZC3HAV12
2 SIMAP similar genes for TIPARP using alignment to 5 protein entries: PARPT_HUMAN (see all proteins):PARP12 PARP11
TIPARP for paralogs About GeneDecksing
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Genomic Variants for TIPARP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TIPARP (156391024 - 156424559 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TIPARP: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIPARP |
|
Disorders
/ Diseases for TIPARP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TIPARP for disorders About GeneDecksing
OMIM gene information: 612480
OMIM disorders: --
3 diseases for TIPARP: About MalaCardshistoplasmosis diphtheria ovarian cancer 1 disease from the University of Copenhagen DISEASES database for TIPARP:Prostate cancer Genetic Association Database (GAD): TIPARP Human Genome Epidemiology (HuGE) Navigator: TIPARP (2 documents) Export disorders for TIPARP gene to outside databases
|
Publications for TIPARP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIPARP gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with TIPARP) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PubMed id 12851707)1, 2, 3, 9 Katoh M. and Katoh M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PubMed id 18762178)1, 9 de Waard P.W....de Kok T.M. (2008)
- A genome-wide association study identifies susceptibi lity loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1 Goode E.L....Pharoah P.D. (2010)
- Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs). (PubMed id 16202152)1 Otto H....Koch-Nolte F. (2005)
- Poly (ADP-ribose) polymerase-1 haplotypes are associated with coeliac disease. (PubMed id 16026592)4 Rueda B....Martin J. (2005)
|
External Searches for TIPARP gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TIPARP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIPARP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIPARP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TIPARP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TIPARP gene: Search GeneIP for patents involving TIPARP
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TIPARP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for TIPARP | | OriGene Custom Protein Services for TIPARP | | OriGene Custom Immunoassay Development | | |
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| | | Search Tocris compounds for TIPARP |
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 | | TIPARP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP |
|  |  |  | | | Search ThermoFisher Antibodies for TIPARP |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP |
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