Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIPARP Gene

protein-coding   GIFtS: 54
GCID: GC03P156391

TCDD-inducible poly(ADP-ribose) polymerase

 Explore 3 diseases affiliated with
TIPARP via our new
 Human Malady Compendium 
Biological research products
for TIPARP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TCDD-Inducible Poly(ADP-Ribose) Polymerase1 2     DDF11
PARP71 2 3     DKFZP434J2141
PART141     DKFZp686N03511
PARP-71 3     PARP-11
Poly [ADP-Ribose] Polymerase 72 3     RM11
ARTD142 3     TCDD-Inducible Poly [ADP-Ribose] Polymerase2
ADP-Ribosyltransferase Diphtheria Toxin-Like 142 3     EC 2.4.2.303

External Ids:    HGNC: 236961   Entrez Gene: 259762   Ensembl: ENSG000001636597   OMIM: 6124805   UniProtKB: Q7Z3E13   

Export aliases for TIPARP gene to outside databases

Previous GC identifers: GC03P157713 GC03P157875 GC03P153788


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIPARP:
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown
that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1
Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues
of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the
protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical
exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity)

Gene Wiki entry for TIPARP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIPARP gene promoter:
         TBP   RORalpha2   Max   GATA-6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIPARP promoter sequence
   Search SABiosciences Chromatin IP Primers for TIPARP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIPARP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q25.31

TIPARP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIPARP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P156391:  view genomic region     (about GC identifiers)

Start:
156,391,024 bp from pter      End:
156,424,559 bp from pter
Size:
33,536 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1 (See protein sequence)
Recommended Name: TCDD-inducible poly [ADP-ribose] polymerase  
Size: 657 amino acids; 76227 Da
Secondary accessions: D3DNK6 Q68CY9 Q86VP4 Q9Y4P7

Explore the universe of human proteins at neXtProt for TIPARP: NX_Q7Z3E1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z3E1

  • TIPARP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171646.1  NP_001171647.1  NP_056323.2  

    ENSEMBL proteins: 
     ENSP00000418757   ENSP00000295924   ENSP00000420612   ENSP00000419982   ENSP00000418829  
     ENSP00000420141   ENSP00000438345  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TIPARP 
    GenScript Custom Purified and Recombinant Proteins Services for TIPARP
    Novus Biologicals TIPARP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TIPARP


    TIPARP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TIPARP 
    GenScript Custom Superior Antibodies Services for TIPARP
    Novus Biologicals TIPARP Antibodies
    Search for Antibodies for TIPARP at Abcam  
    Uscn Antibodies for TIPARP
    Search ThermoFisher Antibodies for TIPARP

    Assay Products for TIPARP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIPARP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TIPARP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TIPARP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR004170 WWE-dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z3E1

    ProtoNet protein and cluster: Q7Z3E1

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 WWE domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1
    Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues
    of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the
    protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical
    exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity)
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

    Enzyme Number (IUBMB): EC 2.4.2.301

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: TIPARP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIPARP
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TIPARP (see all 40):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-562 hsa-miR-29b-1* hsa-miR-3162-5p hsa-miR-105 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTIPARP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIPARP (see all 6)
    OriGene siRNA: TIPARP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIPARP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIPARP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): TIPARP (NM_015508)
    Sino Biological Human cDNA Clone for TIPARP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIPARP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIPARP
    Search LifeMap BioReagents cell lines for TIPARP

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0008270zinc ion binding IEA--


    TIPARP for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for TIPARP:
     Decreased viability  Increased 8N DNA content  Increased cell death HMECs cel 

    Animal Models:
         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tiparp):
     cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  renal/urinary system 
     reproductive system  skeleton 

    TIPARP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIPARP

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for TIPARP (Q7Z3E13 ENSP000002959244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRN2Q9H0D63, ENSP000003663964I2D: score=3 STRING: ENSP00000366396
    ATMQ133153, ENSP000002786164I2D: score=2 STRING: ENSP00000278616
    PARP1P098743I2D: score=1 
    PARP3Q9Y6F13I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001822kidney development IEA--
    GO:0006471protein ADP-ribosylation IEA--
    GO:0006807nitrogen compound metabolic process IEA--
    GO:0008209androgen metabolic process IEA--


    TIPARP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for TIPARP:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIPARP

    1 HMDB Compound for TIPARP    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Search CenterWatch for drugs/clinical trials and news about TIPARP / PARPT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIPARP gene (3 alternative transcripts): 
    NM_001184717.1  NM_001184718.1  NM_015508.4  

    Unigene Cluster for TIPARP:

    TCDD-inducible poly(ADP-ribose) polymerase
    Hs.744050  [show with all ESTs]
    Unigene Representative Sequence: NM_001184717
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486483 ENST00000295924(uc003fav.3) ENST00000461166(uc003faw.3)
    ENST00000473702 ENST00000481853 ENST00000495891 ENST00000542783(uc021xgg.1)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: TIPARP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIPARP
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TIPARP (see all 40):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-562 hsa-miR-29b-1* hsa-miR-3162-5p hsa-miR-105 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTIPARP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIPARP (see all 6)
    OriGene siRNA: TIPARP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIPARP
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): TIPARP (NM_015508)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIPARP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIPARP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIPARP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIPARP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIPARP

    Additional cDNA sequence: 

    AK097785.1 AK291261.1 AL080156.1 BC034397.1 BC050350.1 BX537965.1 CR749647.1 

    6 DOTS entries:

    DT.116445  DT.100711082  DT.100788936  DT.95119625  DT.92432570  DT.95162048 

    11 AceView cDNA sequences:

    BX091689 BC033324 BC038770 BI460811 BG191295 CB048085 BG210943 BG218862 
    BG720335 AA879405 BG201414 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIPARP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATGGCCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TIPARP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIPARP

    SOURCE GeneReport for Unigene cluster: Hs.744050
        SABiosciences Custom PCR Arrays for TIPARP
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIPARP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIPARP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIPARP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIPARP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TIPARP gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TIPARP1 TCDD-inducible poly(ADP-ribose) polymerase 72.43(n)
    69.75(a)
      425026  XM_422828.3  XP_422828.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIPARP6
    --
    64(a)
    1 ↔ 1
    3(15400899-15426897)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98672 Xenopus laevis transcribed sequence with moderate similarity more 78.99(n)    48044178 
    zebrafish
    (Danio rerio)
    Actinopterygii tiparp1 TCDD-inducible poly(ADP-ribose) polymerase 59.07(n)
    56.54(a)
      563506  NM_001045019.3  NP_001038484.1 


    ENSEMBL Gene Tree for TIPARP (if available)
    TreeFam Gene Tree for TIPARP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIPARP gene
    PARP152  PARP112  PARP92  PARP102  PARP142  PARP122  ZC3HAV12  
    2 SIMAP similar genes for TIPARP using alignment to 5 protein entries:     PARPT_HUMAN (see all proteins):
    PARP12    PARP11

    TIPARP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/524 NCBI SNPs in TIPARP are shown (see all 524    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816578241,2
    --156390225(+) AGGCAA/GTTAAC 1 -- us2k10--------
    rs1379574341,2
    --156390538(+) TGACAC/TATTAG 2 -- us2k1 int10--------
    rs562455611,2
    C,--156390599(+) TGTCCC/TCTCTT 2 -- int1 us2k13Minor allele frequency- T:0.07NA WA 240
    rs758902401,2
    C--156390608(+) TTGCAA/GTCCTA 2 -- int1 us2k10--------
    rs758680131,2
    C--156390609(+) TGCAAG/TCCTAA 2 -- int1 us2k10--------
    rs1162431301,2
    F,--156390619(+) AGATTA/TTGATG 2 -- int1 us2k11Minor allele frequency- T:0.02NA 120
    rs744922041,2
    C,F,--156390674(+) AAAAAC/ACAAGG 2 -- int1 us2k11Minor allele frequency- A:0.02EA 120
    rs1859356021,2
    --156390735(+) CCATGC/TCCATA 3 -- us2k1 int10--------
    rs780965431,2
    --156390748(+) TTCCAC/TATCAT 3 -- int1 us2k10--------
    rs1149961591,2
    C,F,--156390773(+) TGTCAT/CGAAAC 3 -- us2k1 int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for TIPARP (156391024 - 156424559 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TIPARP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIPARP
    DNA2.0 Custom Variant and Variant Library Synthesis for TIPARP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TIPARP for disorders           About GeneDecksing

    OMIM gene information: 612480    OMIM disorders: --

    3 diseases for TIPARP:    About MalaCards
    histoplasmosis    diphtheria    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for TIPARP:
    Prostate cancer
    Genetic Association Database (GAD): TIPARP
    Human Genome Epidemiology (HuGE) Navigator: TIPARP (2 documents)

    Export disorders for TIPARP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIPARP gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with TIPARP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PubMed id 12851707)1, 2, 3, 9 Katoh M. and Katoh M. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PubMed id 18762178)1, 9 de Waard P.W....de Kok T.M. (2008)
    4. A genome-wide association study identifies susceptibi lity loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1 Goode E.L....Pharoah P.D. (2010)
    5. Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (2010)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    9. In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs). (PubMed id 16202152)1 Otto H....Koch-Nolte F. (2005)
    10. Poly (ADP-ribose) polymerase-1 haplotypes are associated with coeliac disease. (PubMed id 16026592)4 Rueda B....Martin J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25976 HGNC: 23696 AceView: TIPARP.1 Ensembl:ENSG00000163659 euGenes: HUgn25976
    ECgene: TIPARP H-InvDB: TIPARP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIPARP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIPARP gene:
    Search GeneIP for patents involving TIPARP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for TIPARP
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIPARP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIPARP  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TIPARP   OriGene 3'-UTR Clone for TIPARP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIPARP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TIPARP   OriGene Custom Protein Services for TIPARP  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIPARP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIPARP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIPARP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIPARP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIPARP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIPARP
     GenScript Custom Purified and Recombinant Proteins Services for TIPARP GenScript cDNA clones with any tag delivered in your preferred vector for TIPARP
     GenScript Custom Assay Services for TIPARP GenScript Custom Superior Antibodies Services for TIPARP
     GenScript Custom overexpressing Cell Line Services for TIPARP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TIPARP promoter
     Search Chromatin IP Primers for TIPARP
     RT2 qPCR Primer Assay in human, mouse, rat TIPARP
     Search GNC Networks for TIPARP
     SABiosciences Custom PCR Arrays for TIPARP
     Search Tocris compounds for TIPARP
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for TIPARP
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TIPARP antibodies
     TIPARP lysates
     Search for Antibodies for TIPARP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TIPARP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TIPARP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TIPARP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP
     SwitchGear 3'UTR luciferase reporter plasmids for TIPARP
     SwitchGear Promoter luciferase reporter plasmids for TIPARP
     Search ThermoFisher Antibodies for TIPARP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TIPARP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4