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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIPARP Gene

protein-coding   GIFtS: 55
GCID: GC03P156391

TCDD-Inducible Poly(ADP-Ribose) Polymerase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TCDD-Inducible Poly(ADP-Ribose) Polymerase1 2     pART142
Poly [ADP-Ribose] Polymerase 72 3     TCDD-Inducible Poly [ADP-Ribose] Polymerase2
ARTD142 3     EC 2.4.2.303
PARP72 3     PARP-73
ADP-Ribosyltransferase Diphtheria Toxin-Like 142 3     

External Ids:    HGNC: 236961   Entrez Gene: 259762   Ensembl: ENSG000001636597   OMIM: 6124805   UniProtKB: Q7Z3E13   

Export aliases for TIPARP gene to outside databases

Previous GC identifers: GC03P157713 GC03P157875 GC03P153788


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIPARP Gene:
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have
shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for TIPARP Gene: 
TIPARP (TCDD-inducible poly(ADP-ribose) polymerase) is a protein-coding gene. Diseases associated with TIPARP include diphtheria, and histoplasmosis. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and nucleic acid binding. An important paralog of this gene is PARP15.

UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1
Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid
residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose)
chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative
response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity)

Gene Wiki entry for TIPARP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIPARP gene promoter:
         TBP   RORalpha2   Max   GATA-6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIPARP promoter sequence
   Search SABiosciences Chromatin IP Primers for TIPARP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIPARP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q25.31

TIPARP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIPARP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P156391:  view genomic region     (about GC identifiers)

Start:
156,391,024 bp from pter      End:
156,424,559 bp from pter
Size:
33,536 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1 (See protein sequence)
Recommended Name: TCDD-inducible poly [ADP-ribose] polymerase  
Size: 657 amino acids; 76227 Da
Secondary accessions: D3DNK6 Q68CY9 Q86VP4 Q9Y4P7

Explore the universe of human proteins at neXtProt for TIPARP: NX_Q7Z3E1

Explore proteomics data for TIPARP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z3E1

  • TIPARP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIPARP Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171646.1  NP_001171647.1  NP_056323.2  

    ENSEMBL proteins: 
     ENSP00000418757   ENSP00000295924   ENSP00000420612   ENSP00000419982   ENSP00000418829  
     ENSP00000420141   ENSP00000438345  

    Human Recombinant Protein Products for TIPARP: 
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    Novus Biologicals TIPARP Lysate
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    Cloud-Clone Corp. Proteins for TIPARP 


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    Cloud-Clone Corp. CLIAs for TIPARP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PARP: Poly (ADP-ribose) polymerases

    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR004170 WWE-dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z3E1

    ProtoNet protein and cluster: Q7Z3E1

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 WWE domain


    TIPARP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARPT_HUMAN, Q7Z3E1
    Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid
    residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose)
    chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative
    response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity)
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    TIPARP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TIPARP:
     Decreased viability  Increased 8N DNA content  Increased cell death HMECs cel 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tiparp):
     cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  renal/urinary system 
     reproductive system  skeleton 

    TIPARP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIPARP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIPARP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIPARP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIPARP 

    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TIPARP (see all 40):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-562 hsa-miR-29b-1* hsa-miR-3162-5p hsa-miR-105 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTIPARP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIPARP
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for TIPARP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIPARP
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                         Customized lentivirus expression plasmids for stable overexpression of TIPARP 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIPARP

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for TIPARP (Q7Z3E13 ENSP000002959244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRN2Q9H0D63, ENSP000003663964I2D: score=3 STRING: ENSP00000366396
    ATMQ133153, ENSP000002786164I2D: score=2 STRING: ENSP00000278616
    PARP1P098743I2D: score=1 
    PARP3Q9Y6F13I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001822kidney development IEA--
    GO:0006471protein ADP-ribosylation IEA--
    GO:0006807nitrogen compound metabolic process IEA--
    GO:0008209androgen metabolic process IEA--

    TIPARP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for TIPARP:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIPARP (PARPT)

    1 HMDB Compound for TIPARP    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    Search CenterWatch for drugs/clinical trials and news about TIPARP / PARPT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIPARP gene (3 alternative transcripts): 
    NM_001184717.1  NM_001184718.1  NM_015508.4  

    Unigene Cluster for TIPARP:

    TCDD-inducible poly(ADP-ribose) polymerase
    Hs.744050  [show with all ESTs]
    Unigene Representative Sequence: NM_001184717
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486483 ENST00000295924(uc003fav.3) ENST00000461166(uc003faw.3)
    ENST00000473702 ENST00000481853 ENST00000495891 ENST00000542783(uc021xgg.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIPARP
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TIPARP (see all 40):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-562 hsa-miR-29b-1* hsa-miR-3162-5p hsa-miR-105 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTIPARP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIPARP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIPARP
    Clone
    Products:
         
    OriGene clones in human, mouse for TIPARP (see all 11)
    OriGene ORF clones in mouse, rat for TIPARP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TIPARP (NM_015508)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIPARP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP
    Sirion Biotech Customized lentivirus for stable overexpression of TIPARP 
                         Customized lentivirus expression plasmids for stable overexpression of TIPARP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIPARP
    OriGene qSTAR qPCR primer pairs in human, mouse for TIPARP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIPARP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIPARP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIPARP

    Additional mRNA sequence: 

    AK097785.1 AK291261.1 AL080156.1 BC034397.1 BC050350.1 BX537965.1 CR749647.1 

    6 DOTS entries:

    DT.116445  DT.100711082  DT.100788936  DT.95119625  DT.92432570  DT.95162048 

    11 AceView cDNA sequences:

    BX091689 BC033324 BC038770 BI460811 BG191295 CB048085 BG210943 AA879405 
    BG720335 BG218862 BG201414 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIPARP expression in normal human tissues (normalized intensities)      TIPARP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGGCCAA
    TIPARP Expression
    About this image


    TIPARP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
     
     Ovary (Reproductive System)
             oocyte   
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Brain (Nervous System)
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   

    See TIPARP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIPARP

    SOURCE GeneReport for Unigene cluster: Hs.744050
        SABiosciences Custom PCR Arrays for TIPARP
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIPARP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TIPARP gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tiparp1 , 5 TCDD-inducible poly(ADP-ribose) polymerase1, 5 90.55(n)1
    92.84(a)1
      3 (30.20 cM)5
    999291  NM_178892.51  NP_849223.21 
     655284105 
    chicken
    (Gallus gallus)
    Aves TIPARP1 TCDD-inducible poly(ADP-ribose) polymerase 72.43(n)
    69.75(a)
      425026  XM_422828.3  XP_422828.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIPARP6
    Uncharacterized protein
    65(a)
    1 ↔ 1
    3(15398117-15430460)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98672 Xenopus laevis transcribed sequence with moderate similarity more 78.99(n)    48044178 
    zebrafish
    (Danio rerio)
    Actinopterygii tiparp1 TCDD-inducible poly(ADP-ribose) polymerase 59.07(n)
    56.54(a)
      563506  NM_001045019.3  NP_001038484.1 


    ENSEMBL Gene Tree for TIPARP (if available)
    TreeFam Gene Tree for TIPARP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIPARP gene
    PARP152  PARP92  PARP112  PARP102  PARP142  PARP122  ZC3HAV12  
    2 SIMAP similar genes for TIPARP using alignment to 5 protein entries:     PARPT_HUMAN (see all proteins):
    PARP12    PARP11

    TIPARP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/526 SNPs in TIPARP are shown (see all 526)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354375991,2
    C--153820692(+) TTTTT-/T/TT  
            
    GAGGC
    3 -- ds50011NA 2
    rs1816578241,2
    --156390225(+) AGGCAA/GTTAAC 1 -- us2k10--------
    rs1908413181,2
    C--156395504(+) ACCACC/TGAACC 6 T syn10--------
    rs1408465311,2
    C--156395577(+) TCTCTC/GAGAAG 6 Q E mis10--------
    rs2003490441,2
    --156395610(+) TTAAGA/GAAAAG 6 K E mis10--------
    rs2021989571,2
    --156395612(+) AAGAAA/GAAGGA 6 K syn10--------
    rs98834781,2
    C,F,H--156395672(+) AACACT/GCTTCT 6 /T syn123Minor allele frequency- G:0.05NA NS EA WA CSA EU 7745
    rs2017826701,2
    C--156395848(+) CCAGAC/TACCGG 6 T I mis10--------
    rs753126801,2
    C--156395852(+) ATACCG/AGAAGC 6 /P syn11Minor allele frequency- A:0.01NA 120
    rs1479563531,2
    C--156395884(+) AGAACG/AAGTGG 6 /Q /R mis11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for TIPARP (156391024 - 156424559 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TIPARP: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIPARP
    DNA2.0 Custom Variant and Variant Library Synthesis for TIPARP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612480    OMIM disorders: --

    3 diseases for TIPARP:    About MalaCards
    diphtheria    histoplasmosis    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for TIPARP:
    Prostate cancer

    TIPARP for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIPARP
    Human Genome Epidemiology (HuGE) Navigator: TIPARP (2 documents)

    Export disorders for TIPARP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIPARP gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with TIPARP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PubMed id 12851707)1, 2, 3, 9 Katoh M. and Katoh M. (2003)
    2. A genome-wide association study identifies susceptibi lity loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1, 4 Goode E.L....Pharoah P.D. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PubMed id 18762178)1, 9 de Waard P.W....de Kok T.M. (2008)
    5. Genome-wide association study in BRCA1 mutation carrie rs identifies novel loci associated with breast and ovarian cancer risk. (PubMed id 23544013)1 Couch F.J....Antoniou A.C. (2013)
    6. GWAS meta-analysis and replication identifies three ne w susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (2013)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (2010)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25976 HGNC: 23696 AceView: TIPARP.1 Ensembl:ENSG00000163659 euGenes: HUgn25976
    ECgene: TIPARP H-InvDB: TIPARP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIPARP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIPARP gene:
    Search GeneIP for patents involving TIPARP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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