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Aliases for TIPARP Gene

Aliases for TIPARP Gene

  • TCDD-Inducible Poly(ADP-Ribose) Polymerase 2 3
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 14 3 4
  • Poly [ADP-Ribose] Polymerase 7 3 4
  • ARTD14 3 4
  • PARP7 3 4
  • TCDD-Inducible Poly [ADP-Ribose] Polymerase 3
  • EC 2.4.2.30 4
  • PART14 3
  • PARP-7 4

External Ids for TIPARP Gene

Summaries for TIPARP Gene

Entrez Gene Summary for TIPARP Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for TIPARP Gene

TIPARP (TCDD-Inducible Poly(ADP-Ribose) Polymerase) is a Protein Coding gene. Diseases associated with TIPARP include diphtheria. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for TIPARP Gene

  • Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Gene Wiki entry for TIPARP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPARP Gene

Genomics for TIPARP Gene

Genomic Location for TIPARP Gene

Start:
156,673,235 bp from pter
End:
156,706,770 bp from pter
Size:
33,536 bases
Orientation:
Plus strand

Genomic View for TIPARP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIPARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPARP Gene

Regulatory Elements for TIPARP Gene

Proteins for TIPARP Gene

  • Protein details for TIPARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E1-PARPT_HUMAN
    Recommended name:
    TCDD-inducible poly [ADP-ribose] polymerase
    Protein Accession:
    Q7Z3E1
    Secondary Accessions:
    • D3DNK6
    • Q68CY9
    • Q86VP4
    • Q9Y4P7

    Protein attributes for TIPARP Gene

    Size:
    657 amino acids
    Molecular mass:
    76227 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIPARP Gene

Proteomics data for TIPARP Gene at MOPED

Post-translational modifications for TIPARP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIPARP Gene

Domains for TIPARP Gene

Gene Families for TIPARP Gene

HGNC:
  • PARP :Poly (ADP-ribose) polymerases

Protein Domains for TIPARP Gene

UniProtKB/Swiss-Prot:

PARPT_HUMAN
Domain:
  • Contains 1 PARP catalytic domain.:
    • Q7Z3E1
  • Contains 1 WWE domain.:
    • Q7Z3E1
Similarity:
  • Contains 1 C3H1-type zinc finger.:
    • Q7Z3E1
genes like me logo Genes that share domains with TIPARP: view

Function for TIPARP Gene

Molecular function for TIPARP Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Enzyme Numbers (IUBMB) for TIPARP Gene

Gene Ontology (GO) - Molecular Function for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA 23275542
GO:0035326 enhancer binding IDA 23275542
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIPARP: view
genes like me logo Genes that share phenotypes with TIPARP: view

miRNA for TIPARP Gene

miRTarBase miRNAs that target TIPARP

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TIPARP Gene

Localization for TIPARP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIPARP Gene COMPARTMENTS Subcellular localization image for TIPARP gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23275542
genes like me logo Genes that share ontologies with TIPARP: view

Pathways for TIPARP Gene

SuperPathways for TIPARP Gene

No Data Available

Interacting Proteins for TIPARP Gene

Gene Ontology (GO) - Biological Process for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006471 protein ADP-ribosylation IEA --
GO:0006807 nitrogen compound metabolic process IEA --
GO:0008209 androgen metabolic process IEA --
genes like me logo Genes that share ontologies with TIPARP: view

No data available for Pathways by source for TIPARP Gene

Compounds for TIPARP Gene

(1) HMDB Compounds for TIPARP Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with TIPARP: view

Transcripts for TIPARP Gene

mRNA/cDNA for TIPARP Gene

Unigene Clusters for TIPARP Gene

TCDD-inducible poly(ADP-ribose) polymerase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIPARP Gene

No ASD Table

Relevant External Links for TIPARP Gene

GeneLoc Exon Structure for
TIPARP
ECgene alternative splicing isoforms for
TIPARP

Expression for TIPARP Gene

mRNA expression in normal human tissues for TIPARP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TIPARP Gene Hs.744050

genes like me logo Genes that share expressions with TIPARP: view

Orthologs for TIPARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIPARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPARP 36
  • 99.64 (n)
  • 99.24 (a)
TIPARP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIPARP 36
  • 92.99 (n)
  • 94.97 (a)
TIPARP 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIPARP 36
  • 94.06 (n)
  • 95.13 (a)
TIPARP 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tiparp 36
  • 90.55 (n)
  • 92.84 (a)
Tiparp 16
Tiparp 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIPARP 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIPARP 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tiparp 36
  • 90.24 (n)
  • 92.53 (a)
chicken
(Gallus gallus)
Aves TIPARP 36
  • 72.7 (n)
  • 70.28 (a)
TIPARP 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPARP 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9867 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10375 36
tiparp 36
  • 65.18 (n)
  • 63.85 (a)
zebrafish
(Danio rerio)
Actinopterygii tiparp 36
  • 60.04 (n)
  • 59.26 (a)
tiparp 37
  • 55 (a)
OneToOne
Species with no ortholog for TIPARP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIPARP Gene

ENSEMBL:
Gene Tree for TIPARP (if available)
TreeFam:
Gene Tree for TIPARP (if available)

Paralogs for TIPARP Gene

Paralogs for TIPARP Gene

Selected SIMAP similar genes for TIPARP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIPARP: view

Variants for TIPARP Gene

Sequence variations from dbSNP and Humsavar for TIPARP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs168245 -- 156,688,142(-) CAAAA(A/T)GCTAA intron-variant
rs180747 -- 156,699,300(-) ttgca(C/T)gcagt intron-variant
rs184696 -- 156,695,850(-) AGAAA(A/C)CAGAA intron-variant
rs193197 -- 156,693,943(-) TATCA(C/T)TGGAC intron-variant
rs344005 -- 156,686,753(+) AAATA(A/T)TTTTA intron-variant

Relevant External Links for TIPARP Gene

HapMap Linkage Disequilibrium report
TIPARP

No data available for Structural Variations from Database of Genomic Variants (DGV) for TIPARP Gene

Disorders for TIPARP Gene

(1) MalaCards Diseases for TIPARP Gene

Search for TIPARP Gene in MalaCards »

(1) University of Copenhagen DISEASES for TIPARP Gene

Relevant External Links for TIPARP

Genetic Association Database (GAD)
TIPARP
Human Genome Epidemiology (HuGE) Navigator
TIPARP
genes like me logo Genes that share disorders with TIPARP: view

No data available for UniProtKB/Swiss-Prot for TIPARP Gene

Publications for TIPARP Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PMID: 18762178) de Waard P.W. … de Kok T.M. (Chem. Biol. Interact. 2008) 3 23
  4. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PMID: 20852632) Goode E.L. … Pharoah P.D. (Nat. Genet. 2010) 3 49
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for TIPARP Gene

Sources for TIPARP Gene

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