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TIPARP Gene

protein-coding   GIFtS: 53
GCID: GC03P156391

TCDD-Inducible Poly(ADP-Ribose) Polymerase

  See TIPARP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TCDD-Inducible Poly(ADP-Ribose) Polymerase1 2     pART142
Poly [ADP-Ribose] Polymerase 72 3     TCDD-Inducible Poly [ADP-Ribose] Polymerase2
ARTD142 3     EC 2.4.2.303
PARP72 3     PARP-73
ADP-Ribosyltransferase Diphtheria Toxin-Like 142 3     

External Ids:    HGNC: 236961   Entrez Gene: 259762   Ensembl: ENSG000001636597   OMIM: 6124805   UniProtKB: Q7Z3E13   

Export aliases for TIPARP gene to outside databases

Previous GC identifers: GC03P157713 GC03P157875 GC03P153788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIPARP Gene:
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have
shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for TIPARP Gene:
TIPARP (TCDD-inducible poly(ADP-ribose) polymerase) is a protein-coding gene. Diseases associated with TIPARP include diphtheria. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP15.

UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1
Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid
residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose)
chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive
response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity)

Gene Wiki entry for TIPARP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TIPARP gene promoter:
         TBP   RORalpha2   Max   GATA-6   POU2F1   POU2F1a   STAT3   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIPARP promoter sequence
   Search Chromatin IP Primers for TIPARP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIPARP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q25.31

TIPARP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIPARP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P156391:  view genomic region     (about GC identifiers)

Start:
156,391,024 bp from pter      End:
156,424,559 bp from pter
Size:
33,536 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1 (See protein sequence)
Recommended Name: TCDD-inducible poly [ADP-ribose] polymerase  
Size: 657 amino acids; 76227 Da
Secondary accessions: D3DNK6 Q68CY9 Q86VP4 Q9Y4P7

Explore the universe of human proteins at neXtProt for TIPARP: NX_Q7Z3E1

Explore proteomics data for TIPARP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIPARP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171646.1  NP_001171647.1  NP_056323.2  

    ENSEMBL proteins: 
     ENSP00000418757   ENSP00000295924   ENSP00000420612   ENSP00000419982   ENSP00000418829  
     ENSP00000420141   ENSP00000438345  

    TIPARP Human Recombinant Protein Products:

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    Novus Biologicals TIPARP Lysate
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIPARP

     
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    antibodies-online proteins for TIPARP 

     
    antibodies-online peptides for TIPARP

    TIPARP Antibody Products:

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    antibodies-online antibodies for TIPARP (6 products) 

    TIPARP Assay Products:

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    antibodies-online kits for TIPARP (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PARP: Poly (ADP-ribose) polymerases

    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR004170 WWE-dom
     IPR012317 Poly(ADP-ribose)pol_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z3E1

    ProtoNet protein and cluster: Q7Z3E1

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: PARPT_HUMAN, Q7Z3E1
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 PARP catalytic domain
    Similarity: Contains 1 WWE domain


    Find genes that share domains with TIPARP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PARPT_HUMAN, Q7Z3E1
    Function: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid
    residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose)
    chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive
    response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity)
    Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor

         Enzyme Number (IUBMB): EC 2.4.2.301

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TIPARP           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TIPARP:
     Decreased viability  Increased 8N DNA content  Increased cell death HMECs cel 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tiparp):
     cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  renal/urinary system 
     reproductive system  skeleton 

    Find genes that share phenotypes with TIPARP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TIPARP

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIPARP:
    hsa-mir-26b-5p (MIRT029801), hsa-mir-221-3p (MIRT024175)

    Block miRNA regulation of human, mouse, rat TIPARP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIPARP (see all 40):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-562 hsa-miR-29b-1* hsa-miR-3162-5p hsa-miR-105 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTIPARP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TIPARP

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): TIPARP (NM_015508)
    Sino Biological Human cDNA Clone for TIPARP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIPARP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIPARP
    Interactions:

        Search GeneGlobe Interaction Network for TIPARP

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for TIPARP (Q7Z3E13 ENSP000002959244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRN2Q9H0D63, ENSP000003663964I2D: score=3 STRING: ENSP00000366396
    ATMQ133153, ENSP000002786164I2D: score=2 STRING: ENSP00000278616
    PARP1P098743I2D: score=1 
    PARP3Q9Y6F13I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001822kidney development IEA--
    GO:0006471protein ADP-ribosylation IEA--
    GO:0006807nitrogen compound metabolic process IEA--
    GO:0008209androgen metabolic process IEA--

    Find genes that share ontologies with TIPARP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIPARP (PARPT)

    1 HMDB Compound for TIPARP    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIPARP gene (3 alternative transcripts): 
    NM_001184717.1  NM_001184718.1  NM_015508.4  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486483 ENST00000295924(uc003fav.3) ENST00000461166(uc003faw.3)
    ENST00000473702 ENST00000481853 ENST00000495891 ENST00000542783(uc021xgg.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat TIPARP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIPARP (see all 40):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-562 hsa-miR-29b-1* hsa-miR-3162-5p hsa-miR-105 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTIPARP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TIPARP
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIPARP
    Primer
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    OriGene qPCR primer pairs and template standards for TIPARP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIPARP
      QuantiTect SYBR Green Assays in human, mouse, rat TIPARP
      QuantiFast Probe-based Assays in human, mouse, rat TIPARP

    11 AceView cDNA sequences:

    BX091689 BC033324 BC038770 BI460811 BG191295 CB048085 BG210943 BG720335 
    AA879405 BG218862 BG201414 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIPARP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGGCCAA
    TIPARP Expression
    About this image


    TIPARP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Esophagus (Gastrointestinal Tract)
     
     Adrenal Gland (Endocrine System)
    TIPARP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIPARP Protein Expression
        Custom PCR Arrays for TIPARP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIPARP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TIPARP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tiparp1 , 5 TCDD-inducible poly(ADP-ribose) polymerase1, 5 90.55(n)1
    92.84(a)1
      3 (30.20 cM)5
    999291  NM_178892.51  NP_849223.21 
     655284105 
    chicken
    (Gallus gallus)
    Aves TIPARP1 TCDD-inducible poly(ADP-ribose) polymerase 72.7(n)
    70.28(a)
      425026  XM_422828.4  XP_422828.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIPARP6
    TCDD-inducible poly(ADP-ribose) polymerase
    65(a)
    1 ↔ 1
    3(15398117-15430460)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98672 Xenopus laevis transcribed sequence with moderate similarity more 78.99(n)    48044178 
    zebrafish
    (Danio rerio)
    Actinopterygii tiparp1 TCDD-inducible poly(ADP-ribose) polymerase 60.04(n)
    59.26(a)
      563506  NM_001045019.3  NP_001038484.1 


    ENSEMBL Gene Tree for TIPARP (if available)
    TreeFam Gene Tree for TIPARP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIPARP gene
    PARP152  PARP92  PARP112  PARP102  PARP142  PARP122  ZC3HAV12  
    2 SIMAP similar genes for TIPARP using alignment to 5 protein entries:     PARPT_HUMAN (see all proteins):
    PARP12    PARP11

    Find genes that share paralogs with TIPARP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIPARP (see all 526)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354375991,2
    C--153820692(+) TTTTT-/T/TT  
            
    GAGGC
    3 -- ds50011NA 2
    rs1816578241,2
    --156390225(+) AGGCAA/GTTAAC 1 -- us2k10--------
    rs1908413181,2
    C--156395504(+) ACCACC/TGAACC 6 T syn10--------
    rs1408465311,2
    C--156395577(+) TCTCTC/GAGAAG 6 Q E mis10--------
    rs2003490441,2
    --156395610(+) TTAAGA/GAAAAG 6 K E mis10--------
    rs2021989571,2
    --156395612(+) AAGAAA/GAAGGA 6 K syn10--------
    rs98834781,2
    C,F,H--156395672(+) AACACT/GCTTCT 6 /T syn123Minor allele frequency- G:0.05NA NS EA WA CSA EU 7745
    rs2017826701,2
    C--156395848(+) CCAGAC/TACCGG 6 T I mis10--------
    rs753126801,2
    C--156395852(+) ATACCG/AGAAGC 6 /P syn11Minor allele frequency- A:0.01NA 120
    rs1479563531,2
    C--156395884(+) AGAACG/AAGTGG 6 /Q /R mis11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for TIPARP (156391024 - 156424559 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TIPARP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIPARP
    DNA2.0 Custom Variant and Variant Library Synthesis for TIPARP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612480    OMIM disorders: --

    1 disease for TIPARP:    
    About MalaCards
    diphtheria

    1 disease from the University of Copenhagen DISEASES database for TIPARP:
    Prostate cancer

    Find genes that share disorders with TIPARP           About GenesLikeMe

    Genetic Association Database (GAD): TIPARP
    Human Genome Epidemiology (HuGE) Navigator: TIPARP (2 documents)

    Export disorders for TIPARP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIPARP gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TIPARP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PubMed id 12851707)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1, 4 Goode E.L....Pharoah P.D. (Nat. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PubMed id 18762178)1, 9 de Waard P.W....de Kok T.M. (Chem. Biol. Interact. 2008)
    5. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. (PubMed id 23544013)1 Couch F.J....Antoniou A.C. (PLoS Genet. 2013)
    6. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (Trends Biochem. Sci. 2010)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25976 HGNC: 23696 AceView: TIPARP.1 Ensembl:ENSG00000163659 euGenes: HUgn25976
    ECgene: TIPARP H-InvDB: TIPARP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TIPARP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIPARP gene:
    Search GeneIP for patents involving TIPARP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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