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Aliases for TIPARP Gene

Aliases for TIPARP Gene

  • TCDD Inducible Poly(ADP-Ribose) Polymerase 2 3
  • TCDD-Inducible Poly(ADP-Ribose) Polymerase 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 14 3 4
  • Poly [ADP-Ribose] Polymerase 7 3 4
  • ARTD14 3 4
  • PARP7 3 4
  • EC 2.4.2.30 4
  • PART14 3
  • PARP-7 4

External Ids for TIPARP Gene

Previous GeneCards Identifiers for TIPARP Gene

  • GC03P157713
  • GC03P157875
  • GC03P156391
  • GC03P153788

Summaries for TIPARP Gene

Entrez Gene Summary for TIPARP Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for TIPARP Gene

TIPARP (TCDD Inducible Poly(ADP-Ribose) Polymerase) is a Protein Coding gene. Diseases associated with TIPARP include male reproductive organ cancer. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enhancer binding. An important paralog of this gene is PARP14.

UniProtKB/Swiss-Prot for TIPARP Gene

  • Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Gene Wiki entry for TIPARP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPARP Gene

Genomics for TIPARP Gene

Regulatory Elements for TIPARP Gene

Genomic Location for TIPARP Gene

Chromosome:
3
Start:
156,673,235 bp from pter
End:
156,706,770 bp from pter
Size:
33,536 bases
Orientation:
Plus strand

Genomic View for TIPARP Gene

Genes around TIPARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIPARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIPARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPARP Gene

Proteins for TIPARP Gene

  • Protein details for TIPARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E1-PARPT_HUMAN
    Recommended name:
    TCDD-inducible poly [ADP-ribose] polymerase
    Protein Accession:
    Q7Z3E1
    Secondary Accessions:
    • D3DNK6
    • Q68CY9
    • Q86VP4
    • Q9Y4P7

    Protein attributes for TIPARP Gene

    Size:
    657 amino acids
    Molecular mass:
    76227 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIPARP Gene

Proteomics data for TIPARP Gene at MOPED

Post-translational modifications for TIPARP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIPARP Gene

Domains & Families for TIPARP Gene

Gene Families for TIPARP Gene

Protein Domains for TIPARP Gene

Suggested Antigen Peptide Sequences for TIPARP Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3E1

UniProtKB/Swiss-Prot:

PARPT_HUMAN :
  • Contains 1 PARP catalytic domain.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • Contains 1 PARP catalytic domain.
  • Contains 1 WWE domain.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with TIPARP: view

Function for TIPARP Gene

Molecular function for TIPARP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Enzyme Numbers (IUBMB) for TIPARP Gene

genes like me logo Genes that share phenotypes with TIPARP: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIPARP Gene

Localization for TIPARP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIPARP Gene COMPARTMENTS Subcellular localization image for TIPARP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TIPARP Gene

Pathways & Interactions for TIPARP Gene

SuperPathways for TIPARP Gene

No Data Available

Interacting Proteins for TIPARP Gene

Gene Ontology (GO) - Biological Process for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006471 protein ADP-ribosylation IEA --
GO:0006807 nitrogen compound metabolic process IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TIPARP: view

No data available for Pathways by source and SIGNOR curated interactions for TIPARP Gene

Drugs & Compounds for TIPARP Gene

(2) Drugs for TIPARP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 353,361
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with TIPARP: view

Transcripts for TIPARP Gene

mRNA/cDNA for TIPARP Gene

Unigene Clusters for TIPARP Gene

TCDD-inducible poly(ADP-ribose) polymerase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIPARP Gene

No ASD Table

Relevant External Links for TIPARP Gene

GeneLoc Exon Structure for
TIPARP
ECgene alternative splicing isoforms for
TIPARP

Expression for TIPARP Gene

mRNA expression in normal human tissues for TIPARP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TIPARP Gene Hs.744050

genes like me logo Genes that share expression patterns with TIPARP: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TIPARP Gene

Orthologs for TIPARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIPARP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIPARP 35
  • 92.99 (n)
  • 94.97 (a)
TIPARP 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIPARP 35
  • 94.06 (n)
  • 95.13 (a)
TIPARP 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tiparp 35
  • 90.55 (n)
  • 92.84 (a)
Tiparp 16
Tiparp 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIPARP 35
  • 99.64 (n)
  • 99.24 (a)
TIPARP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tiparp 35
  • 90.24 (n)
  • 92.53 (a)
oppossum
(Monodelphis domestica)
Mammalia TIPARP 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIPARP 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPARP 35
  • 72.7 (n)
  • 70.28 (a)
TIPARP 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPARP 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10375 35
tiparp 35
  • 65.18 (n)
  • 63.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9867 35
zebrafish
(Danio rerio)
Actinopterygii tiparp 35
  • 60.04 (n)
  • 59.26 (a)
tiparp 36
  • 55 (a)
OneToOne
Species with no ortholog for TIPARP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIPARP Gene

ENSEMBL:
Gene Tree for TIPARP (if available)
TreeFam:
Gene Tree for TIPARP (if available)

Paralogs for TIPARP Gene

Paralogs for TIPARP Gene

(2) SIMAP similar genes for TIPARP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIPARP: view

Variants for TIPARP Gene

Sequence variations from dbSNP and Humsavar for TIPARP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17854621 - 156,695,994(+) TCTTC(A/C/T)GCTCC reference, missense
rs168245 -- 156,688,142(-) CAAAA(A/T)GCTAA intron-variant
rs168295 -- 156,679,378(+) CAACT(G/T)GTATT intron-variant
rs343991 -- 156,681,953(-) TGTTC(C/G)AGACT intron-variant, downstream-variant-500B
rs180747 -- 156,699,300(-) ttgca(C/T)gcagt intron-variant

Variation tolerance for TIPARP Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIPARP Gene

HapMap Linkage Disequilibrium report
TIPARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIPARP Gene

Disorders for TIPARP Gene

MalaCards: The human disease database

(1) MalaCards diseases for TIPARP Gene - From: DISEASES

Disorder Aliases PubMed IDs
male reproductive organ cancer
  • male genital cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TIPARP

Genetic Association Database (GAD)
TIPARP
Human Genome Epidemiology (HuGE) Navigator
TIPARP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIPARP
genes like me logo Genes that share disorders with TIPARP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIPARP Gene

Publications for TIPARP Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 23 67
  2. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PMID: 18762178) de Waard P.W. … de Kok T.M. (Chem. Biol. Interact. 2008) 3 23
  3. Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. (PMID: 24806346) MacPherson L. … Matthews J. (Int J Mol Sci 2014) 3
  4. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. (PMID: 23275542) MacPherson L. … Matthews J. (Nucleic Acids Res. 2013) 3
  5. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3

Products for TIPARP Gene

Sources for TIPARP Gene

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