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TINF2 Gene

protein-coding GIFtS: 57

GC14M023778

TERF1 (TRF1)-interacting nuclear factor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TIN2 ^¹, ², ³, ⁵
TIN2L ^²

Descriptions
(TRF1)-interacting nuclear factor 2 variant 1 ^²
TERF1 (TRF1)-interacting nuclear factor 2 ^²
TERF1-interacting nuclear factor 2 ^¹
TRF1-interacting nuclear protein 2 ^³

External Ids
HGNC: 11824¹
Entrez Gene: 26277²
UniProtKB: Q9BSI4³
Ensembl: ENSG00000092330⁷

Search outside databases for aliases for TINF2 gene

Previous GC identifers: GC14M022081 GC14M018496 GC14M022698

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TINF2_HUMAN, Q9BSI4

Function: Component of the shelterin complex (telosome) that is involved in the regulation of

telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats

added by telomerase and protects chromosome ends; without its protective activity, telomeres are

no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately

processed by DNA repair pathways. Plays a role in shelterin complex assembly

Gene Wiki entry for TINF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TINF2 gene

Entrez Gene cytogenetic band: 14q12 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q12

TINF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M023778: (about GC identifiers)

Start:	23,778,689 bp from pter
End:	23,781,720 bp from pter
Size:	3,032 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TINF2_HUMAN, Q9BSI4 (See protein sequence)

Recommended Name: TERF1-interacting nuclear factor 2

Size: 451 amino acids; 50023 Da

Subunit: Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex

(telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TERF1 and ACD

Subcellular location: Nucleus. Telomere. Note=Associated with telomeres

PDB structure from and Proteopedia :

3BQO (3D)

3BU8 (3D)

Secondary accessions: Q9H904 Q9UHC2

Alternative splicing: 3 isoforms: Q9BSI4-1 Q9BSI4-2 Q9BSI4-3 (Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001092744.1 NP_036593.2

ENSEMBL proteins:

ENSP00000382350 ENSP00000267415

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Tin2)
	Human Recombinant Proteins from Abnova (TINF2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000781	chromosome, telomeric region	IEA	--
GO:0000783	nuclear telomere cap complex	IDA	16880378
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	16166375
GO:0005694	chromosome	IEA	--

About this table

Antibodies for TINF2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Tin2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TINF2)
	Novus Biologicals Antibodies for TINF2

Assays for TINF2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9BSI4

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TINF2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TINF2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001099274

Applied Biosystems Silencer® siRNAs for TINF2

Sigma-Aldrich siRNA for TINF2

Sigma-Aldrich shRNA for TINF2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TINF2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099274
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099274
untagged cDNA clones in CMV expression vector (see all 2): NM_001099274

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001099274

UniProtKB/Swiss-Prot: TINF2_HUMAN, Q9BSI4

Function: Component of the shelterin complex (telosome) that is involved in the regulation of

telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats

added by telomerase and protects chromosome ends; without its protective activity, telomeres are

no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately

processed by DNA repair pathways. Plays a role in shelterin complex assembly

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Tinf2):

lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	NOT DNA binding	IDA	10581025
GO:0008022	protein C-terminus binding	IPI	15380063
GO:0042162	telomeric DNA binding	IDA	12768206

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TINF2

5/15 Interacting proteins for TINF2 (ENSP00000267415³ Q9BSI4^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TERF2	Q15554¹	STRING (score=.999) EBI-717418, EBI-706637
TERF2IP	Q9NYB0¹	STRING (score=.999) EBI-717418, EBI-750109
TERF1	P54274¹^,²	STRING (score=.999) EBI-717418, EBI-710997 MINT-14930 EBI-717418, EBI-710997 MINT-14930
TERF1	P54274¹^,²	STRING (score=.999) EBI-717418, EBI-710997 MINT-14930 EBI-717418, EBI-710997 MINT-14930
STAG1	Q8WVM7²	MINT-6178228

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010833	telomere maintenance via telomere lengthening	IMP	18669893
GO:0010836	negative regulation of protein amino acid ADP-ribosylation	IGI	15133513
GO:0032202	telomere assembly	IMP	16880378
GO:0032206	positive regulation of telomere maintenance	IMP	18443218
GO:0032211	negative regulation of telomere maintenance via telomerase	IGI	10581025

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TINF2
1 Novoseek chemical compound relationship for TINF2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tin(2+)	99.58	152	15133513 (7), 15316005 (6), 15292264 (6), 12835755 (6) (see all 32)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TINF2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TINF2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001099274

Sigma-Aldrich siRNA for TINF2

Sigma-Aldrich shRNA for TINF2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001099274 NM_012461

REFSEQ mRNAs for TINF2 gene (2 alternative transcripts):

NM_001099274.1 NM_012461.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001099274 NM_012461

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099274
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099274
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001099274

Additional cDNA sequence:

AF195512.1 AK225379.1 AK294119.1 AK315084.1 BC005030.1 BC019343.1 BX161478.1 CR590257.1

CR591539.1 CR596834.1 CR598536.1 CR600876.1 CR606987.1 CR613506.1 CR614984.1 CR615677.1

CR617274.1 CR621443.1 CR623530.1 CR623801.1 CR626188.1 EU851975.1

17 DOTS entries:

DT.100857582 DT.95129903 DT.100705911 DT.100857577 DT.100728937 DT.218638 DT.95259981 DT.100857581

DT.120749371 DT.95259977 DT.100028932 DT.100760573 DT.100831834 DT.100857575 DT.101966840 DT.120749389

DT.95259965

24/341 AceView cDNA sequences (see all 341 ):

AI368049 N23175 CA941396 W02711 W76343 BF793349 CR600876 AA430551

BQ669124 BI868341 BQ222471 BU634287 AI027194 CB853427 BP374789 BQ901147

AA292380 AA921358 AI332595 BQ773794 AA039987 CR596834 CR598536 N35812

highest scoring ESTs for TINF2:

AA128884 AA128892 AA448970 AA926811 AF195512 AL598952 AU143347 AU279638 AV686147 BC005030

Unigene Cluster for TINF2:

TERF1 (TRF1)-interacting nuclear factor 2

Hs.496191 [show with all ESTs]

Unigene Representative Sequence: NM_012461

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TINF2 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11a	·	11b
SP1:
SP2:
SP3:							-
SP4:													-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for TINF2

2 Ensembl transcripts including schematic representations:

ENST00000399423 ENST00000267415

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TINF2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TINF2

¹ / ² / ³

7 probe-sets matching TINF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57237_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	W25667	0.80	1.00	0.91	1
220052_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012461	0.60	1.00	0.82	1
224809_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK023166	0.60	1.00	0.82	1
223776_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC005030	0.80	1.00	0.91	1
220052_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224809_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223776_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTCAGAATT

SOURCE GeneReport for Unigene cluster: Hs.496191
UniProtKB/Swiss-Prot: TINF2_HUMAN, Q9BSI4
Tissue specificity: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and
pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TINF2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TINF2¹	--	TERF1 (TRF1)-interacting nuclear factor 2	84.94(n) 80.97(a)	608377 XM_845393.1 XP_850486.1
chimpanzee (Pan troglodytes)	TINF2¹	--	TERF1 (TRF1)-interacting nuclear factor 2	99.26(n) 98.89(a)	452813 XM_509868.2 XP_509868.2
cow (Bos taurus)	TINF2¹	--	TERF1 (TRF1)-interacting nuclear factor 2	84.52(n) 79.69(a)	540420 XM_593926.3 XP_593926.3
rat (Rattus norvegicus)	Tinf2¹	--	TERF1 (TRF1)-interacting nuclear factor 2	76.66(n) 71.03(a)	290232 NM_001006962.1 NP_001006963.1
mouse (Mus musculus)	Tinf2^{1, 5}	14 (22.50 cM)⁵	Terf1 (TRF1)-interacting nuclear factor 2^{1, 5}	75.12(n)¹ 65.94(a)¹	28113¹ NM_145705.2¹ NP_663751.2¹ AA408032⁵ AF214013⁵ (see all 25)

About this table Species with no ortholog for TINF2

ENSEMBL Gene Tree for TINF2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/42 NCBI SNPs in TINF2 are shown (see all 42 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs766601^1,2	A,C,F,H	23781934(-)	`CCTCAC/GGGGAG`	2	--	ng3¹		8	NA EA MN EU WA	840
	rs10141326^1,2	A,C,F,H	23779191(+)	`AGAGAC/TGGAGG`	2	P/P	syn¹ ut3¹ ese³		16	NA MN CSAM EA EU WA	1378
	rs17102313^1,2	C,F,H	23779816(+)	`GTGTGC/TCAGGC`	2	G/D	mis¹		16	NA MN CSAM EA EU WA	1358
	rs17102311^1,2	C,F,H	23779805(+)	`CTGAGG/AAAGAT`	2	S/P	mis¹ ese³		16	NA MN CSAM EA EU WA	1372
--	rs8016076^1,2	C,F	23782098(+)	`TCCTTT/CTATAA`	2	--	ng3¹ tfbs³		3	NA	142
	rs28372734^1,2	C,F	23781638(-)	`GCGACG/CTTTAA`	2	--	ut5¹ ese³		7	MN EA CSAM	1640
	rs10148135^1,2	F,H	23782133(+)	`AAAAAT/GAAAAT`	2	--	ng3¹		4	EU EA WA	414
	rs766602^1,2	C,H	23781658(-)	`CCCTCG/TGGCTC`	2	--	ut5¹		9	EU EA WA MN CSAM	806
	rs35886534^1,2	F	23781644(-)	`ACAGCG/AGCGAC`	2	--	ut5¹		5	MN CSAM EA	388
--	rs12897870^1,2	H	23779012(+)	`TATCCG/CAAACC`	2	--	ut3¹ int¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for TINF2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604319 disorders: 127550 268130

UniProtKB/Swiss-Prot: TINF2_HUMAN, Q9BSI4

Defects in TINF2 are a cause of dyskeratosis congenita autosomal dominant (ADDKC)

[MIM:127550]; also known as dyskeratosis congenita Scoggins type. ADDKC is a rare, progressive

bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation,

nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow

failure, infections, fatal pulmonary complications, or malignancy

Defects in TINF2 are a cause of retinopathy exudative with bone marrow failure (ERBMF)

[MIM:268130]; also known as Revesz syndrome. ERBMF is characterized by bilateral exudative

retinopathy, bone marrow hypoplasia, nail dystrophy, fine hair, cerebellar hypoplasia, and growth

retardation

3 Novoseek disease relationships for TINF2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric carcinoma	29.39	6	11494028 (3), 12007281 (1)
cancer	15.05	2	12530079 (1), 15181449 (1)
carcinoma	0.00	2	11494028 (2)

About this table

Human Gene Mutation Database: TINF2
Human Genome Epidemiology Navigator: TINF2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/45 PubMed articles for TINF2 gene (see all 45 ):

TIN2, a new regulator of telomere length in human cells. (PubMed id 10581025)^{1, 2, 3, 4} Kim S.-H.... Campisi J. (1999)
TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. (PubMed id 18252230)^{2, 3, 4} Savage S.A....Alter B.P. (2008)
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. (PubMed id 15316005)^{1, 3, 4} Ye J.Z....de Lange T. (2004)
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. (PubMed id 16880378)^{1, 3, 4} O'Connor M.S....Songyang Z. (2006)
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. (PubMed id 15383534)^{1, 3, 4} Liu D....Songyang Z. (2004)
Shelterin: the protein complex that shapes and safeguards human telomeres. (PubMed id 16166375)^{1, 3, 4} de Lange T. (2005)
POT1 as a terminal transducer of TRF1 telomere length control. (PubMed id 12768206)^{1, 3, 4} Loayza D. and De Lange T. (2003)
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. (PubMed id 15231715)^{3, 4} Ye J.Z.-S.... de Lange T. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26277	HGNC: 11824	AceView: TINF2	Ensembl:ENSG00000092330	euGenes: HUgn26277
ECgene: TINF2	H-InvDB: TINF2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TINF2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TINF2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TINF2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TINF2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TINF2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TINF2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TINF2)
	Antibodies (TINF2)
	Chimera RNAi (TINF2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Tin2)
	Antibodies (Tin2)

Search OriGene for TINF2

Search Tocris compounds for TINF2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TINF2

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TINF2 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for TINF2

Summaries
for TINF2

Genomic Location
for TINF2

Proteins
for TINF2

Protein Domains/
Families
for TINF2

Gene Function
for TINF2

Pathways & Interactions
for TINF2

Drugs & Compounds
for TINF2

Transcripts
for TINF2

Expression
for TINF2

Orthologs
for TINF2

Paralogs
for TINF2

SNPs/Variants
for TINF2

Disorders & Mutations
for TINF2

Medical News
for TINF2

Publications
for TINF2

Search for TINF2

Genome Databases showing TINF2

Other Databases showing TINF2

Specialized Databases showing TINF2

Licensable Technologies
for TINF2

Services
for TINF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TINF2 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor TINF2

Summariesfor TINF2

Genomic Locationfor TINF2

Proteinsfor TINF2

Protein Domains/Familiesfor TINF2

Gene Functionfor TINF2

Pathways & Interactionsfor TINF2

Drugs & Compoundsfor TINF2

Transcriptsfor TINF2

Expression for TINF2

Orthologsfor TINF2

Paralogsfor TINF2

SNPs/Variantsfor TINF2

Disorders & Mutationsfor TINF2

Medical Newsfor TINF2

Publicationsfor TINF2

Search for TINF2

Genome Databases showing TINF2

Other Databases showing TINF2

Specialized Databases showing TINF2

Licensable Technologiesfor TINF2

Servicesfor TINF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TINF2

Summaries
for TINF2

Genomic Location
for TINF2

Proteins
for TINF2

Protein Domains/
Families
for TINF2

Gene Function
for TINF2

Pathways & Interactions
for TINF2

Drugs & Compounds
for TINF2

Transcripts
for TINF2

Expression
for TINF2

Orthologs
for TINF2

Paralogs
for TINF2

SNPs/Variants
for TINF2

Disorders & Mutations
for TINF2

Medical News
for TINF2

Publications
for TINF2

Licensable Technologies
for TINF2

Services
for TINF2