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Aliases for TINCR Gene

Subcategory (RNA class) for TINCR Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for TINCR Gene

  • Tissue Differentiation-Inducing Non-Protein Coding RNA 2 3 5
  • Long Intergenic Non-Protein Coding RNA 36 2 3
  • Placenta-Specific 2 (Non-Protein Coding) 2 3
  • Terminal Differentiation-Induced NcRNA 2 3
  • Non-Protein Coding RNA 36 2
  • Placenta-Specific 2 2
  • Onco-LncRNA-16 3
  • NCRNA00036 3
  • LINC00036 3
  • PLAC2 3

External Ids for TINCR Gene

Previous HGNC Symbols for TINCR Gene

  • PLAC2

Summaries for TINCR Gene

Entrez Gene Summary for TINCR Gene

  • This gene produces a spliced long non-coding RNA that is required for normal epidermal differentiation. This transcript regulates the expression of genes involved in the differentiation of epidermal tissue. Mutations in some of the genes targeted by this transcript have been implicated in epidermal skin diseases. [provided by RefSeq, Apr 2015]

GeneCards Summary for TINCR Gene

TINCR (Tissue Differentiation-Inducing Non-Protein Coding RNA) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TINCR Gene

Genomics for TINCR Gene

Regulatory Elements for TINCR Gene

Enhancers for TINCR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G005567 1 Ensembl ENCODE 0.7 +0.1 133 1.0 CTCF KLF1 ZNF777 SIN3A CEBPG RBBP5 ZIC2 ZNF48 ZNF157 POLR2A TINCR GC19M005554
GH19G005563 0.9 ENCODE 0.7 +3.8 3839 2.3 PKNOX1 KLF17 SIN3A BMI1 RAD21 ZNF335 ZNF121 GLIS2 ZNF366 FOS LONP1 RPL36 GC19M005554 TINCR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TINCR on UCSC Golden Path with GeneCards custom track

Genomic Location for TINCR Gene

Chromosome:
19
Start:
5,558,167 bp from pter
End:
5,568,034 bp from pter
Size:
9,868 bases
Orientation:
Minus strand

Genomic View for TINCR Gene

Genes around TINCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TINCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TINCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINCR Gene

Proteins for TINCR Gene

  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GTR7
    Recommended name:
    Tissue differentiation-inducing non-protein coding RNA
    Protein Accession:
    A0A1B0GTR7

    Protein attributes for TINCR Gene

    Size:
    56 amino acids
    Molecular mass:
    6469 Da
    Quaternary structure:
    No Data Available
  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GVN0
    Recommended name:
    Tissue differentiation-inducing non-protein coding RNA
    Protein Accession:
    A0A1B0GVN0

    Protein attributes for TINCR Gene

    Size:
    87 amino acids
    Molecular mass:
    10124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TINCR Gene

Post-translational modifications for TINCR Gene

No Post-translational modifications

Other Protein References for TINCR Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TINCR Gene

Domains & Families for TINCR Gene

Gene Families for TINCR Gene

Protein Domains for TINCR Gene

Suggested Antigen Peptide Sequences for TINCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TINCR: view

No data available for UniProtKB/Swiss-Prot for TINCR Gene

Function for TINCR Gene

Phenotypes for TINCR Gene

genes like me logo Genes that share phenotypes with TINCR: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TINCR Gene

Localization for TINCR Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TINCR Gene

Pathways & Interactions for TINCR Gene

SuperPathways for TINCR Gene

No Data Available

Interacting Proteins for TINCR Gene

Gene Ontology (GO) - Biological Process for TINCR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TINCR Gene

Transcripts for TINCR Gene

mRNA/cDNA for TINCR Gene

Unigene Clusters for TINCR Gene

Tissue differentiation-inducing non-protein coding RNA:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TINCR Gene

No ASD Table

Relevant External Links for TINCR Gene

GeneLoc Exon Structure for
TINCR
ECgene alternative splicing isoforms for
TINCR

Expression for TINCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TINCR Gene

mRNA differential expression in normal tissues according to GTEx for TINCR Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.2), Skin - Not Sun Exposed (Suprapubic) (x12.8), and Esophagus - Mucosa (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of TINCR Gene:

TINCR

SOURCE GeneReport for Unigene cluster for TINCR Gene:

Hs.515575
genes like me logo Genes that share expression patterns with TINCR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TINCR Gene

Orthologs for TINCR Gene

Evolution for TINCR Gene

ENSEMBL:
Gene Tree for TINCR (if available)
TreeFam:
Gene Tree for TINCR (if available)

No data available for Orthologs for TINCR Gene

Paralogs for TINCR Gene

No data available for Paralogs for TINCR Gene

Variants for TINCR Gene

Sequence variations from dbSNP and Humsavar for TINCR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000107404 -- 5,562,748(+) CCAGA(C/T)TCAAG intron-variant
rs1000139312 -- 5,569,181(+) AAAAA(-/G)AAAGA upstream-variant-2KB
rs1000178061 -- 5,564,049(+) GACAA(A/C)CTGTC intron-variant
rs1000546238 -- 5,562,481(+) TATGT(A/G)CCAGG intron-variant
rs1000696305 -- 5,567,925(+) TCCAT(A/C/G)GCGCC nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TINCR Gene

Variant ID Type Subtype PubMed ID
esv3643529 CNV gain 21293372
nsv1062851 CNV gain 25217958

Relevant External Links for TINCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TINCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TINCR Gene

Disorders for TINCR Gene

Relevant External Links for TINCR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TINCR

No disorders were found for TINCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TINCR Gene

Publications for TINCR Gene

  1. TINCR, staufen1, and cellular differentiation. (PMID: 24019000) Kretz M. (RNA Biol 2013) 2 3 64
  2. Control of somatic tissue differentiation by the long non-coding RNA TINCR. (PMID: 23201690) Kretz M. … Khavari P.A. (Nature 2013) 2 3 64
  3. Long noncoding RNA, tissue differentiation-inducing nonprotein coding RNA is upregulated and promotes development of esophageal squamous cell carcinoma. (PMID: 26833746) Xu Y. … Yin R. (Dis. Esophagus 2016) 3 64
  4. Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function. (PMID: 25864709) Cabanski C.R. … Maher C.A. (RNA Biol 2015) 3 64
  5. A LncRNA-MAF:MAFB Transcription Factor Network Regulates Epidermal Differentiation. (PMID: 25805135) Lopez-Pajares V. … Khavari P.A. (Dev. Cell 2015) 3 64

Products for TINCR Gene

Sources for TINCR Gene

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