Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TINAGL1 Gene

Aliases for TINAGL1 Gene

  • Tubulointerstitial Nephritis Antigen-Like 1 2 3
  • Tubulointerstitial Nephritis Antigen-Related Protein 3 4
  • Glucocorticoid-Inducible Protein 5 3 4
  • TIN Ag-Related Protein 3 4
  • TINAG-Like 1 2 3
  • Lipocalin 7 2 3
  • TIN-Ag-RP 3 4
  • OLRG-2 3 4
  • LCN7 3 4
  • Tubulointerstitial Nephritis Antigen-Like 3
  • Oxidized LDL-Responsive Gene 2 Protein 4
  • Oxidized-LDL Responsive Gene 2 3
  • Androgen-Regulated Gene 1 3
  • TINAGRP 3
  • LIECG3 3
  • P3ECSL 3
  • TINAGL 4
  • OLRG2 4
  • ARG1 3
  • GIS5 4

External Ids for TINAGL1 Gene

Previous HGNC Symbols for TINAGL1 Gene

  • LCN7

Previous GeneCards Identifiers for TINAGL1 Gene

  • GC01P031712
  • GC01P031814
  • GC01P032042
  • GC01P030159

Summaries for TINAGL1 Gene

Entrez Gene Summary for TINAGL1 Gene

  • The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for TINAGL1 Gene

TINAGL1 (Tubulointerstitial Nephritis Antigen-Like 1) is a Protein Coding gene. Diseases associated with TINAGL1 include nephritis. Among its related pathways are NgR-p75(NTR)-Mediated Signaling and Metabolism. GO annotations related to this gene include cysteine-type peptidase activity and scavenger receptor activity. An important paralog of this gene is CTSB.

UniProtKB/Swiss-Prot for TINAGL1 Gene

  • May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).

Gene Wiki entry for TINAGL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TINAGL1 Gene

Genomics for TINAGL1 Gene

Regulatory Elements for TINAGL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TINAGL1 Gene

Start:
31,576,485 bp from pter
End:
31,587,689 bp from pter
Size:
11,205 bases
Orientation:
Plus strand

Genomic View for TINAGL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TINAGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINAGL1 Gene

Proteins for TINAGL1 Gene

  • Protein details for TINAGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM7-TINAL_HUMAN
    Recommended name:
    Tubulointerstitial nephritis antigen-like
    Protein Accession:
    Q9GZM7
    Secondary Accessions:
    • A8K9Q5
    • B4DPK6
    • D3DPN8
    • Q8TEJ9
    • Q8WZ23
    • Q96GZ4
    • Q96JW3

    Protein attributes for TINAGL1 Gene

    Size:
    467 amino acids
    Molecular mass:
    52387 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TINAGL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TINAGL1 Gene

Proteomics data for TINAGL1 Gene at MOPED

Post-translational modifications for TINAGL1 Gene

Other Protein References for TINAGL1 Gene

Antibody Products

No data available for DME Specific Peptides for TINAGL1 Gene

Domains for TINAGL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZM7

UniProtKB/Swiss-Prot:

TINAL_HUMAN :
  • Q9GZM7
Domain:
  • Contains 1 SMB (somatomedin-B) domain.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with TINAGL1: view

No data available for Gene Families for TINAGL1 Gene

Function for TINAGL1 Gene

Molecular function for TINAGL1 Gene

UniProtKB/Swiss-Prot Function:
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).

Gene Ontology (GO) - Molecular Function for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005201 extracellular matrix structural constituent NAS 11170462
GO:0005515 protein binding IPI 25416956
GO:0008234 cysteine-type peptidase activity IEA --
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with TINAGL1: view

Animal Model Products

CRISPR Products

miRNA for TINAGL1 Gene

miRTarBase miRNAs that target TINAGL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TINAGL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TINAGL1 Gene

Localization for TINAGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TINAGL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TINAGL1 Gene COMPARTMENTS Subcellular localization image for TINAGL1 gene
Compartment Confidence
extracellular 5
lysosome 3
cytoskeleton 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11170462
GO:0005615 extracellular space ISS 22261194
GO:0005737 cytoplasm IEA --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with TINAGL1: view

Pathways for TINAGL1 Gene

genes like me logo Genes that share pathways with TINAGL1: view

Pathways by source for TINAGL1 Gene

1 Qiagen pathway for TINAGL1 Gene
1 Cell Signaling Technology pathway for TINAGL1 Gene
3 Reactome pathways for TINAGL1 Gene
1 GeneGo (Thomson Reuters) pathway for TINAGL1 Gene

Gene Ontology (GO) - Biological Process for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0016197 endosomal transport TAS 10799322
genes like me logo Genes that share ontologies with TINAGL1: view

Compounds for TINAGL1 Gene

(2) Novoseek inferred chemical compound relationships for TINAGL1 Gene

Compound -log(P) Hits PubMed IDs
arachidonic acid 24.8 1
cysteine 16.4 1
genes like me logo Genes that share compounds with TINAGL1: view

Transcripts for TINAGL1 Gene

Unigene Clusters for TINAGL1 Gene

Tubulointerstitial nephritis antigen-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TINAGL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TINAGL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10:
SP11: - -

Relevant External Links for TINAGL1 Gene

GeneLoc Exon Structure for
TINAGL1
ECgene alternative splicing isoforms for
TINAGL1

Expression for TINAGL1 Gene

mRNA expression in normal human tissues for TINAGL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TINAGL1 Gene

This gene is overexpressed in Artery - Aorta (4.1).

Protein differential expression in normal tissues for TINAGL1 Gene

This gene is overexpressed in Gallbladder (14.9), Adipocyte (6.3), and Rectum (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TINAGL1 Gene

SOURCE GeneReport for Unigene cluster for TINAGL1 Gene Hs.199368

mRNA Expression by UniProt/SwissProt for TINAGL1 Gene

Q9GZM7-TINAL_HUMAN
Tissue specificity: Highly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line. Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid. Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney.
genes like me logo Genes that share expressions with TINAGL1: view

Expression partners for TINAGL1 Gene

In Situ Assay Products

Orthologs for TINAGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TINAGL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TINAGL1 35
  • 88.76 (n)
  • 90.62 (a)
TINAGL1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TINAGL1 35
  • 91.42 (n)
  • 92.7 (a)
TINAGL1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tinagl1 35
  • 85.2 (n)
  • 89.91 (a)
Tinagl1 16
Tinagl1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TINAGL1 35
  • 97.43 (n)
  • 97.64 (a)
TINAGL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tinagl1 35
  • 85.72 (n)
  • 89.69 (a)
oppossum
(Monodelphis domestica)
Mammalia TINAGL1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TINAGL1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TINAGL1 35
  • 72.84 (n)
  • 69.3 (a)
TINAGL1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TINAGL1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tinagl1 35
  • 65.38 (n)
  • 67.95 (a)
zebrafish
(Danio rerio)
Actinopterygii tinagl1 35
  • 65.24 (n)
  • 64.94 (a)
tinagl1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007684 35
  • 52.85 (n)
  • 43.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Swim 35
  • 54.85 (n)
  • 46.43 (a)
Swim 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F26E4.3 35
  • 49.22 (n)
  • 47.17 (a)
F26E4.3 36
  • 39 (a)
OneToMany
Species with no ortholog for TINAGL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TINAGL1 Gene

ENSEMBL:
Gene Tree for TINAGL1 (if available)
TreeFam:
Gene Tree for TINAGL1 (if available)

Paralogs for TINAGL1 Gene

Paralogs for TINAGL1 Gene

Selected SIMAP similar genes for TINAGL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TINAGL1: view

Variants for TINAGL1 Gene

Sequence variations from dbSNP and Humsavar for TINAGL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs945212 -- 31,582,465(-) gtgac(A/G)acaag intron-variant
rs945213 -- 31,582,031(-) cttat(A/C)cctgt intron-variant
rs945214 -- 31,581,704(-) cctgg(A/C/T)ccatc intron-variant
rs1107550 -- 31,582,451(-) ctgca(C/T)gctct intron-variant
rs2992032 -- 31,576,228(+) ATATC(C/T)CCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TINAGL1 Gene

Variant ID Type Subtype PubMed ID
dgv46e1 CNV Complex 17122850
nsv10062 CNV Gain+Loss 18304495
dgv26e201 CNV Deletion 23290073
esv2746419 CNV Deletion 23290073
dgv27e201 CNV Deletion 23290073
esv1695245 CNV Deletion 17803354
esv2746441 CNV Deletion 23290073
esv2746452 CNV Deletion 23290073

Relevant External Links for TINAGL1 Gene

HapMap Linkage Disequilibrium report
TINAGL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TINAGL1 Gene

Disorders for TINAGL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TINAGL1 Gene in MalaCards »

(1) Diseases for TINAGL1 Gene including...

(1) Novoseek inferred disease relationships for TINAGL1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 15.2 1
genes like me logo Genes that share disorders with TINAGL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for TINAGL1 Gene

Publications for TINAGL1 Gene

  1. TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells. (PMID: 11170462) Wex T. … Broemme D. (Biochemistry 2001) 2 3 4 23
  2. Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins. (PMID: 12482659) Goernemann J. … Mueller M. (Virology 2002) 3 23
  3. Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein. (PMID: 10799322) Broemme N.C. … Broemme D. (Biochem. Biophys. Res. Commun. 2000) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TINAGL1 Gene

Sources for TINAGL1 Gene

Back to Top

Content