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TINAGL1 Gene

protein-coding   GIFtS: 54
GCID: GC01P032042

Tubulointerstitial Nephritis Antigen-Like 1

(Previous names: lipocalin 7, TINAG-like 1)
(Previous symbol: LCN7)
  See TINAGL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulointerstitial Nephritis Antigen-Like 11 2     LIECG32
LCN71 2 3     P3ECSL2
Lipocalin 71 2     TINAGRP2
TINAG-Like 11 2     Androgen-Regulated Gene 12
Glucocorticoid-Inducible Protein 52 3     Oxidized-LDL Responsive Gene 22
Tubulointerstitial Nephritis Antigen-Related Protein2 3     Tubulointerstitial Nephritis Antigen-Like2
OLRG-22 3     GIS53
TIN-Ag-RP2 3     OLRG23
TIN Ag-Related Protein2 3     TINAGL3
ARG12     Oxidized LDL-Responsive Gene 2 Protein3

External Ids:    HGNC: 191681   Entrez Gene: 641292   Ensembl: ENSG000001429107   UniProtKB: Q9GZM73   

Export aliases for TINAGL1 gene to outside databases

Previous GC identifers: GC01P031712 GC01P031814 GC01P030159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TINAGL1 Gene:
The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted
glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for TINAGL1 Gene:
TINAGL1 (tubulointerstitial nephritis antigen-like 1) is a protein-coding gene. Diseases associated with TINAGL1 include nephritis. GO annotations related to this gene include cysteine-type peptidase activity and scavenger receptor activity. An important paralog of this gene is TINAG.

UniProtKB/Swiss-Prot: TINAL_HUMAN, Q9GZM7
Function: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene
expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity)

Gene Wiki entry for TINAGL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TINAGL1 gene promoter:
         FOXF2   HTF   STAT5A   E4BP4   GATA-2   RORalpha1   FOXO4   STAT3   ZIC2/Zic2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTINAGL1 promoter sequence
   Search Chromatin IP Primers for TINAGL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TINAGL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.2   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p34.3

TINAGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TINAGL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032042:  view genomic region     (about GC identifiers)

Start:
32,042,086 bp from pter      End:
32,053,288 bp from pter
Size:
11,203 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TINAL_HUMAN, Q9GZM7 (See protein sequence)
Recommended Name: Tubulointerstitial nephritis antigen-like precursor  
Size: 467 amino acids; 52387 Da
Sequence caution: Sequence=AAH09048.1; Type=Erroneous initiation; Sequence=BAB55403.1; Type=Erroneous initiation;
Secondary accessions: A8K9Q5 B4DPK6 D3DPN8 Q8TEJ9 Q8WZ23 Q96GZ4 Q96JW3
Alternative splicing: 3 isoforms:  Q9GZM7-1   Q9GZM7-2   Q9GZM7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TINAGL1: NX_Q9GZM7

Explore proteomics data for TINAGL1 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn78, Asn161

  • See TINAGL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001191343.1  NP_001191344.1  NP_071447.1  

    ENSEMBL proteins: 
     ENSP00000271064   ENSP00000395137   ENSP00000445392   ENSP00000411798  

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    Cloud-Clone Corp. Proteins for TINAGL1

     
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    antibodies-online peptides for TINAGL1

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    antibodies-online antibodies for TINAGL1 (34 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013128 Peptidase_C1A
     IPR025660 Pept_his_AS
     IPR000668 Peptidase_C1A_C
     IPR001212 Somatomedin_B_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZM7

    ProtoNet protein and cluster: Q9GZM7

    1 Blocks protein domain: IPB000668 Papain cysteine protease (C1) family signature

    UniProtKB/Swiss-Prot: TINAL_HUMAN, Q9GZM7
    Similarity: Belongs to the peptidase C1 family
    Similarity: Contains 1 SMB (somatomedin-B) domain


    Find genes that share domains with TINAGL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TINAL_HUMAN, Q9GZM7
    Function: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene
    expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity IEA--
    GO:0005201extracellular matrix structural constituent NAS11170462
    GO:0008234cysteine-type peptidase activity IEA--
    GO:0030247polysaccharide binding IEA--
    GO:0043236laminin binding IEA--
         
    Find genes that share ontologies with TINAGL1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Tinagl1 (no phenotypes)

    Find genes that share phenotypes with TINAGL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tinagl1tm1Lex for TINAGL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TINAGL1
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    miRNA
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    miRTarBase miRNAs that target TINAGL1:
    hsa-mir-7-5p (MIRT025899), hsa-mir-30a-5p (MIRT028633), hsa-mir-1 (MIRT024079)

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    8 qRT-PCR Assays for microRNAs that regulate TINAGL1:
    hsa-miR-4283 hsa-miR-185* hsa-miR-566 hsa-miR-450b-3p hsa-miR-9 hsa-miR-637 hsa-miR-3151 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTINAGL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TINAGL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TINAL_HUMAN, Q9GZM7: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome3
    cytoskeleton1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11170462
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IEA--
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with TINAGL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TINAGL1
        NgR-p75(NTR)-Mediated Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TINAGL1
    Interactions:

        Search GeneGlobe Interaction Network for TINAGL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TINAGL1 (Q9GZM72, 3 ENSP000002710644) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO4P619682, 3, ENSP000003595734MINT-60894 I2D: score=3 STRING: ENSP00000359573
    MED31Q9Y3C72, 3MINT-65403 I2D: score=5 
    UTP14AQ9BVJ62, 3MINT-65402 I2D: score=5 
    SMAD9O151982, 3, ENSP000003691544MINT-62060 I2D: score=3 STRING: ENSP00000369154
    MDFIQ997502, 3, ENSP000002303214MINT-67389 I2D: score=5 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006955immune response IEA--
    GO:0016197endosomal transport TAS10799322

    Find genes that share ontologies with TINAGL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TINAGL1 (TINAL)

    2 Novoseek inferred chemical compound relationships for TINAGL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 24.8 1 2143470 (1)
    cysteine 16.4 1 15195995 (1)



    Find genes that share compounds with TINAGL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TINAGL1 gene (3 alternative transcripts): 
    NM_001204414.1  NM_001204415.1  NM_022164.2  

    Unigene Cluster for TINAGL1:

    Tubulointerstitial nephritis antigen-like 1
    Hs.199368  [show with all ESTs]
    Unigene Representative Sequence: AK128451
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000271064(uc001bta.3 uc021oko.1) ENST00000461030 ENST00000466998
    ENST00000478398 ENST00000481165(uc010ogk.1) ENST00000468635 ENST00000498429
    ENST00000463112 ENST00000480586 ENST00000457433(uc010ogj.2) ENST00000537531
    ENST00000441210(uc010ogi.1)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TINAGL1:
    hsa-miR-4283 hsa-miR-185* hsa-miR-566 hsa-miR-450b-3p hsa-miR-9 hsa-miR-637 hsa-miR-3151 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTINAGL1 3' UTR sequence
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    Additional mRNA sequence: 

    AB050716.1 AF205436.1 AF236150.1 AK027839.1 AK075398.1 AK128451.1 AK292770.1 AK296322.1 
    AK298382.1 AY358421.1 BC009048.1 BC064633.1 HM016160.1 HM016161.1 

    22 DOTS entries:

    DT.422155  DT.100874963  DT.100874968  DT.100802912  DT.100803505  DT.100764098  DT.121371351  DT.99986408 
    DT.91979496  DT.121371414  DT.100874952  DT.100874956  DT.121371291  DT.121371304  DT.121371350  DT.75179546 
    DT.91671691  DT.91741226  DT.100833503  DT.121371410  DT.92043384  DT.97859640 

    Selected AceView cDNA sequences (see all 92):

    BM053143 AI439381 BM923842 CB106240 AF289569 BE902304 BM763831 AK074124 
    BQ690538 BG985052 CA487392 BX283995 CR596614 BE744387 BM761000 BX337515 
    BM843928 BE902110 BM764416 BG422865 BG748344 BX338121 BX380922 BM847376 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TINAGL1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
    SP1:                    -     -           -     -           -     -                                                     -                           
    SP2:                    -     -     -     -     -           -     -                                                                                 
    SP3:                                            -           -     -                                                                                 
    SP4:                                                              -                                                                                 
    SP5:                                                                                                              -     -                           


    ECgene alternative splicing isoforms for TINAGL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TINAGL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCATCACT
    TINAGL1 Expression
    About this image


    TINAGL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Choroid Plexus
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis
    TINAGL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TINAGL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199368

    UniProtKB/Swiss-Prot: TINAL_HUMAN, Q9GZM7
    Tissue specificity: Highly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line.
    Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid.
    Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular
    smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TINAGL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TINAGL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tinagl11 , 5 tubulointerstitial nephritis antigen-like 11, 5 85.2(n)1
    89.91(a)1
      4 (63.43 cM)5
    942421  NM_001168333.11  NP_001161805.11 
     1301644545 
    chicken
    (Gallus gallus)
    Aves TINAGL11 tubulointerstitial nephritis antigen-like 1 72.84(n)
    69.3(a)
      430648  XM_428202.4  XP_428202.3 
    lizard
    (Anolis carolinensis)
    Reptilia TINAGL16
    tubulointerstitial nephritis antigen-like 1
    66(a)
    1 ↔ 1
    GL343308.1(378039-421083)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tinagl11 tubulointerstitial nephritis antigen-like 1 65.38(n)
    67.95(a)
      100124858  XM_004911603.1  XP_004911660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tinagl11 tubulointerstitial nephritis antigen-like 1 65.24(n)
    64.94(a)
      562116  NM_001044977.2  NP_001038442.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Swim1 Secreted Wg-interacting molecule 54.85(n)
    46.43(a)
      37537  NM_137808.2  NP_611652.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F26E4.31 F26E4.3 49.22(n)
    47.17(a)
      172827  NM_060192.6  NP_492593.2 


    ENSEMBL Gene Tree for TINAGL1 (if available)
    TreeFam Gene Tree for TINAGL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TINAGL1 gene
    TINAG2  CTSB2  
    1 SIMAP similar gene for TINAGL1 using alignment to 3 protein entries:     TINAL_HUMAN (see all proteins):
    TINAG

    Find genes that share paralogs with TINAGL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TINAGL1 (see all 415)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128790401,2
    C,F--32044024(+) AATTTC/TAGTGA 3 -- int12Minor allele frequency- T:0.50NA 4
    rs1112571151,2
    C,F--32044030(+) AGTGAG/CAGCTG 3 -- int12Minor allele frequency- C:0.50NA 4
    rs1117410781,2
    C--32044395(+) TGATGC/TCTTCA 3 -- int10--------
    rs559095261,2
    C--32044446(+) TGATGC/TCTTCA 3 -- int10--------
    rs3731222031,2
    C--32044478(+) AGCTG-/GTGTGTGT
    /GTGTGTGTGT
    GTGTG
    3 -- int10--------
    rs577691421,2
    C--32044481(+) GTGTG-/TGTGTG
    /TGTGTGTG
    ATATC
    6 -- int1 cds10--------
    rs3684274051,2
    C--32044541(+) GAGCT-/GGTATG 3 -- int10--------
    rs127493921,2
    C--32044542(+) AGCTGT/GTATGT 3 -- int11Minor allele frequency- G:0.00WA 2
    rs725499091,2
    C--32045665(+) TGCAC-/TGTGTG
            
    TGTGT
    3 -- int10--------
    rs57733661,2
    C--32047928(+) AAAAAA/-GCGGG 3 -- int1 trp31Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for TINAGL1 (32042086 - 32053288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TINAGL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv27e201CNV Deletion23290073
    dgv26e201CNV Deletion23290073
    esv2746452CNV Deletion23290073
    esv2746441CNV Deletion23290073
    esv1695245CNV Deletion17803354
    esv2746419CNV Deletion23290073
    nsv10062CNV Gain+Loss18304495
    dgv46e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TINAGL1
    DNA2.0 Custom Variant and Variant Library Synthesis for TINAGL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TINAGL1:    
    About MalaCards
    nephritis


    Find genes that share disorders with TINAGL1           About GenesLikeMe

    1 Novoseek inferred disease relationship for TINAGL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 15.2 1 15962097 (1)


    Export disorders for TINAGL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TINAGL1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with TINAGL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells. (PubMed id 11170462)1, 2, 3, 9 Wex T.... Broemme D. (Biochemistry 2001)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein. (PubMed id 10799322)1, 2 Broemme N.C.... Broemme D. (Biochem. Biophys. Res. Commun. 2000)
    9. Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins. (PubMed id 12482659)1, 9 Goernemann J.... Mueller M. (Virology 2002)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64129 HGNC: 19168 AceView: LCN7 Ensembl:ENSG00000142910 euGenes: HUgn64129
    ECgene: TINAGL1 H-InvDB: TINAGL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TINAGL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TINAGL1 gene:
    Search GeneIP for patents involving TINAGL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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