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Aliases for TINAG Gene

Aliases for TINAG Gene

  • Tubulointerstitial Nephritis Antigen 2 3
  • TIN-AG 3 4
  • TIN2 6
  • TIN1 6

External Ids for TINAG Gene

Summaries for TINAG Gene

Entrez Gene Summary for TINAG Gene

  • This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

GeneCards Summary for TINAG Gene

TINAG (Tubulointerstitial Nephritis Antigen) is a Protein Coding gene. Diseases associated with TINAG include nephritis. GO annotations related to this gene include nucleotide binding and scavenger receptor activity. An important paralog of this gene is CTSB.

UniProtKB/Swiss-Prot for TINAG Gene

  • Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.

Gene Wiki entry for TINAG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TINAG Gene

Genomics for TINAG Gene

Genomic Location for TINAG Gene

54,307,859 bp from pter
54,390,152 bp from pter
82,294 bases
Plus strand

Genomic View for TINAG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TINAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINAG Gene

Regulatory Elements for TINAG Gene

Proteins for TINAG Gene

  • Protein details for TINAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulointerstitial nephritis antigen
    Protein Accession:
    Secondary Accessions:
    • Q5T467
    • Q9UJW1
    • Q9ULZ4

    Protein attributes for TINAG Gene

    476 amino acids
    Molecular mass:
    54605 Da
    Quaternary structure:
    No Data Available
    • Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury

    Alternative splice isoforms for TINAG Gene


neXtProt entry for TINAG Gene

Proteomics data for TINAG Gene at MOPED

Post-translational modifications for TINAG Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn38, Asn175, Asn314, Asn360, and Asn455

Other Protein References for TINAG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TINAG Gene

Domains for TINAG Gene

Suggested Antigen Peptide Sequences for TINAG Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SMB (somatomedin-B) domain.:
    • Q9UJW2
  • Belongs to the peptidase C1 family.:
    • Q9UJW2
genes like me logo Genes that share domains with TINAG: view

No data available for Gene Families for TINAG Gene

Function for TINAG Gene

Molecular function for TINAG Gene

UniProtKB/Swiss-Prot Function: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.

Gene Ontology (GO) - Molecular Function for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 10652240
GO:0004197 cysteine-type endopeptidase activity TAS 10652240
GO:0005044 scavenger receptor activity IEA --
GO:0008234 cysteine-type peptidase activity --
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with TINAG: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TINAG Gene

Localization for TINAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TINAG Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

Jensen Localization Image for TINAG Gene COMPARTMENTS Subcellular localization image for TINAG gene
Compartment Confidence
extracellular 5
lysosome 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IDA 1762287
genes like me logo Genes that share ontologies with TINAG: view

Pathways for TINAG Gene

SuperPathways for TINAG Gene

No Data Available

Interacting Proteins for TINAG Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000259782 Q9UJW2-TINAG_HUMAN for TINAG Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion IDA 8770961
genes like me logo Genes that share ontologies with TINAG: view

No data available for Pathways by source for TINAG Gene

Compounds for TINAG Gene

(1) Novoseek inferred chemical compound relationships for TINAG Gene

Compound -log(P) Hits PubMed IDs
cysteine 36.4 2
genes like me logo Genes that share compounds with TINAG: view

Transcripts for TINAG Gene

Unigene Clusters for TINAG Gene

Tubulointerstitial nephritis antigen:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TINAG Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - - -
SP3: - -

Relevant External Links for TINAG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TINAG Gene

mRNA expression in normal human tissues for TINAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TINAG Gene

This gene is overexpressed in Kidney - Cortex (29.6), Colon - Transverse (12.7), and Small Intestine - Terminal Ileum (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TINAG Gene

SOURCE GeneReport for Unigene cluster for TINAG Gene Hs.127011

mRNA Expression by UniProt/SwissProt for TINAG Gene

Tissue specificity: Expressed in the kidney cortex, small intestine and cornea.
genes like me logo Genes that share expressions with TINAG: view

Orthologs for TINAG Gene

This gene was present in the common ancestor of animals.

Orthologs for TINAG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TINAG 35
  • 99.44 (n)
  • 99.37 (a)
  • 99 (a)
(Bos Taurus)
Mammalia TINAG 35
  • 89.15 (n)
  • 89.29 (a)
  • 89 (a)
(Canis familiaris)
Mammalia TINAG 35
  • 91.46 (n)
  • 91.18 (a)
  • 91 (a)
(Mus musculus)
Mammalia Tinag 35
  • 86.81 (n)
  • 85.68 (a)
Tinag 16
Tinag 36
  • 86 (a)
(Monodelphis domestica)
Mammalia TINAG 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TINAG 36
  • 65 (a)
(Rattus norvegicus)
Mammalia Tinag 35
  • 86.67 (n)
  • 85.05 (a)
(Gallus gallus)
Aves TINAG 35
  • 62.6 (n)
  • 55.77 (a)
  • 54 (a)
(Anolis carolinensis)
Reptilia TINAG 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Swim 36
  • 37 (a)
CG3074 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea F26E4.3 36
  • 36 (a)
F26E4.3 37
  • 41 (a)
Species with no ortholog for TINAG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TINAG Gene

Gene Tree for TINAG (if available)
Gene Tree for TINAG (if available)

Paralogs for TINAG Gene

Paralogs for TINAG Gene

Selected SIMAP similar genes for TINAG Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TINAG: view

Variants for TINAG Gene

Sequence variations from dbSNP and Humsavar for TINAG Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs483213 -- 54,322,678(+) ATAGA(A/C)AGTCA intron-variant
rs507257 -- 54,369,676(-) AGTTG(C/T)TGCTA intron-variant
rs556741 -- 54,318,686(-) catgt(A/C)gcttc intron-variant, upstream-variant-2KB
rs587260 -- 54,350,162(-) GTATA(C/T)ACACA intron-variant
rs605608 -- 54,311,879(-) CTTCA(A/C)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TINAG Gene

Variant ID Type Subtype PubMed ID
nsv885888 CNV Gain 21882294
nsv819178 CNV Gain 19587683

Relevant External Links for TINAG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TINAG Gene

Disorders for TINAG Gene

(1) MalaCards Diseases for TINAG Gene

Search for TINAG Gene in MalaCards »

(2) University of Copenhagen DISEASES for TINAG Gene

(3) Novoseek inferred disease relationships for TINAG Gene

Disease -log(P) Hits PubMed IDs
tubulointerstitial nephritis 95.1 21
nephritis 57.6 1
nephropathy membranous 55.6 1

Relevant External Links for TINAG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TINAG: view

No data available for UniProtKB/Swiss-Prot for TINAG Gene

Publications for TINAG Gene

  1. Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen. (PMID: 10652240) Ikeda M. … Yoshioka K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag). (PMID: 10752525) Zhou B. … Charonis A.S. (J. Am. Soc. Nephrol. 2000) 3 4 23
  3. Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy. (PMID: 1466368) Katz A. … Butkowski R.J. (Am. J. Med. 1992) 3 4 23
  4. Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms. (PMID: 1762287) Butkowski R.J. … Fish A.J. (Kidney Int. 1991) 3 4 23
  5. Receptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen. (PMID: 8770961) Chen Y. … Charonis A.S. (Kidney Int. 1996) 3 4 23

Products for TINAG Gene

Sources for TINAG Gene

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