External Ids for TINAG Gene
Previous GeneCards Identifiers for TINAG Gene
This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
GeneCards Summary for TINAG Gene
TINAG (Tubulointerstitial Nephritis Antigen) is a Protein Coding gene. Diseases associated with TINAG include Membranous Nephropathy and Interstitial Nephritis. GO annotations related to this gene include nucleotide binding and cysteine-type peptidase activity. An important paralog of this gene is CTSZ.
UniProtKB/Swiss-Prot for TINAG Gene
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.