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Aliases for TINAG Gene

Aliases for TINAG Gene

  • Tubulointerstitial Nephritis Antigen 2 3 5
  • TIN-AG 3 4

External Ids for TINAG Gene

Previous GeneCards Identifiers for TINAG Gene

  • GC06P054175
  • GC06P054220
  • GC06P054006

Summaries for TINAG Gene

Entrez Gene Summary for TINAG Gene

  • This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

GeneCards Summary for TINAG Gene

TINAG (Tubulointerstitial Nephritis Antigen) is a Protein Coding gene. Diseases associated with TINAG include Membranous Nephropathy and Interstitial Nephritis. GO annotations related to this gene include nucleotide binding and cysteine-type peptidase activity. An important paralog of this gene is CTSZ.

UniProtKB/Swiss-Prot for TINAG Gene

  • Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.

Gene Wiki entry for TINAG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TINAG Gene

Genomics for TINAG Gene

Regulatory Elements for TINAG Gene

Enhancers for TINAG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TINAG on UCSC Golden Path with GeneCards custom track

Genomic Location for TINAG Gene

Chromosome:
6
Start:
54,307,792 bp from pter
End:
54,390,152 bp from pter
Size:
82,361 bases
Orientation:
Plus strand

Genomic View for TINAG Gene

Genes around TINAG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TINAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TINAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINAG Gene

Proteins for TINAG Gene

  • Protein details for TINAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW2-TINAG_HUMAN
    Recommended name:
    Tubulointerstitial nephritis antigen
    Protein Accession:
    Q9UJW2
    Secondary Accessions:
    • Q5T467
    • Q9UJW1
    • Q9ULZ4

    Protein attributes for TINAG Gene

    Size:
    476 amino acids
    Molecular mass:
    54605 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.

    Alternative splice isoforms for TINAG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TINAG Gene

Proteomics data for TINAG Gene at MOPED

Post-translational modifications for TINAG Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Glycosylation at Asn 38, Asn 175, Asn 314, Asn 360, and Asn 455
  • Modification sites at PhosphoSitePlus

Other Protein References for TINAG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TINAG Gene

Domains & Families for TINAG Gene

Suggested Antigen Peptide Sequences for TINAG Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJW2

UniProtKB/Swiss-Prot:

TINAG_HUMAN :
  • Contains 1 SMB (somatomedin-B) domain.
  • Belongs to the peptidase C1 family.
Domain:
  • Contains 1 SMB (somatomedin-B) domain.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with TINAG: view

No data available for Gene Families for TINAG Gene

Function for TINAG Gene

Molecular function for TINAG Gene

UniProtKB/Swiss-Prot Function:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.

Gene Ontology (GO) - Molecular Function for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 10652240
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with TINAG: view

Phenotypes for TINAG Gene

GenomeRNAi human phenotypes for TINAG:
genes like me logo Genes that share phenotypes with TINAG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TINAG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TINAG Gene

Localization for TINAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for TINAG Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TINAG Gene COMPARTMENTS Subcellular localization image for TINAG gene
Compartment Confidence
extracellular 5
lysosome 2
vacuole 2
cytosol 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TINAG Gene

Pathways & Interactions for TINAG Gene

SuperPathways for TINAG Gene

No Data Available

Interacting Proteins for TINAG Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000259782%0d%0a9606.ENSP00000276603%0d%0a9606.ENSP00000181383%0d%0a9606.ENSP00000281441%0d%0a
Selected Interacting proteins: ENSP00000259782 Q9UJW2-TINAG_HUMAN for TINAG Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TINAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with TINAG: view

No data available for Pathways by source and SIGNOR curated interactions for TINAG Gene

Drugs & Compounds for TINAG Gene

(1) Drugs for TINAG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TINAG: view

Transcripts for TINAG Gene

Unigene Clusters for TINAG Gene

Tubulointerstitial nephritis antigen:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TINAG Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for TINAG Gene

GeneLoc Exon Structure for
TINAG
ECgene alternative splicing isoforms for
TINAG

Expression for TINAG Gene

mRNA expression in normal human tissues for TINAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TINAG Gene

This gene is overexpressed in Kidney - Cortex (x29.6), Colon - Transverse (x12.7), and Small Intestine - Terminal Ileum (x6.4).

Protein differential expression in normal tissues from HIPED for TINAG Gene

This gene is overexpressed in Kidney (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TINAG Gene



SOURCE GeneReport for Unigene cluster for TINAG Gene Hs.127011

mRNA Expression by UniProt/SwissProt for TINAG Gene

Q9UJW2-TINAG_HUMAN
Tissue specificity: Expressed in the kidney cortex, small intestine and cornea.
genes like me logo Genes that share expression patterns with TINAG: view

Primer Products

No data available for Protein tissue co-expression partners for TINAG Gene

Orthologs for TINAG Gene

This gene was present in the common ancestor of animals.

Orthologs for TINAG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TINAG 35
  • 89.15 (n)
  • 89.29 (a)
TINAG 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TINAG 35
  • 91.46 (n)
  • 91.18 (a)
TINAG 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tinag 35
  • 86.81 (n)
  • 85.68 (a)
Tinag 16
Tinag 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TINAG 35
  • 99.44 (n)
  • 99.37 (a)
TINAG 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tinag 35
  • 86.67 (n)
  • 85.05 (a)
oppossum
(Monodelphis domestica)
Mammalia TINAG 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TINAG 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TINAG 35
  • 62.6 (n)
  • 55.77 (a)
TINAG 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TINAG 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3074 37
  • 39 (a)
Swim 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F26E4.3 37
  • 41 (a)
F26E4.3 36
  • 36 (a)
OneToMany
Species with no ortholog for TINAG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TINAG Gene

ENSEMBL:
Gene Tree for TINAG (if available)
TreeFam:
Gene Tree for TINAG (if available)

Paralogs for TINAG Gene

Paralogs for TINAG Gene

(1) SIMAP similar genes for TINAG Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TINAG: view

Variants for TINAG Gene

Sequence variations from dbSNP and Humsavar for TINAG Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs16885197 - 54,308,557(+) TGTGG(A/G)CCGGA intron-variant, reference, missense
rs2297980 - 54,308,615(-) AATAC(C/T)GCTTC nc-transcript-variant, reference, missense
rs1058768 - 54,321,349(+) TTCGT(C/T)CAGAA intron-variant, nc-transcript-variant, reference, missense
rs34011963 - 54,354,623(+) ATGCA(A/G)TCAAA nc-transcript-variant, reference, missense
rs3736352 - 54,389,791(-) AGCAA(G/T)CTGCA nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for TINAG Gene

Variant ID Type Subtype PubMed ID
nsv885888 CNV Gain 21882294
nsv819178 CNV Gain 19587683

Variation tolerance for TINAG Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.41; 88.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TINAG Gene

Human Gene Mutation Database (HGMD)
TINAG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TINAG Gene

Disorders for TINAG Gene

MalaCards: The human disease database

(2) MalaCards diseases for TINAG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
membranous nephropathy
  • membranous glomerulonephritis, antenatal
interstitial nephritis
  • renal tubulo-interstitial disease
- elite association - COSMIC cancer census association via MalaCards
Search TINAG in MalaCards View complete list of genes associated with diseases

Relevant External Links for TINAG

Genetic Association Database (GAD)
TINAG
Human Genome Epidemiology (HuGE) Navigator
TINAG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TINAG
genes like me logo Genes that share disorders with TINAG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TINAG Gene

Publications for TINAG Gene

  1. Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen. (PMID: 10652240) Ikeda M. … Yoshioka K. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23 67
  2. A tubulointerstitial nephritis antigen gene defect causes childhood-onset chronic renal failure. (PMID: 20157734) Takemura Y. … Takemura T. (Pediatr. Nephrol. 2010) 3 23
  3. Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag). (PMID: 10752525) Zhou B. … Charonis A.S. (J. Am. Soc. Nephrol. 2000) 3 23
  4. Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron. (PMID: 9643646) Nelson T.R. … Charonis A.S. (Connect. Tissue Res. 1998) 3 23
  5. Receptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen. (PMID: 8770961) Chen Y. … Charonis A.S. (Kidney Int. 1996) 3 23

Products for TINAG Gene

Sources for TINAG Gene

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