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Aliases for TIMP4 Gene

Aliases for TIMP4 Gene

  • TIMP Metallopeptidase Inhibitor 4 2 3
  • Tissue Inhibitor Of Metalloproteinases 4 3 4
  • Tissue Inhibitor Of Metalloproteinase 4 2 3
  • TIMP-4 3 4
  • Metalloproteinase Inhibitor 4 3

External Ids for TIMP4 Gene

Summaries for TIMP4 Gene

Entrez Gene Summary for TIMP4 Gene

  • This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIMP4 Gene

TIMP4 (TIMP Metallopeptidase Inhibitor 4) is a Protein Coding gene. Diseases associated with TIMP4 include prostate cancer. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include metalloendopeptidase inhibitor activity. An important paralog of this gene is TIMP2.

UniProtKB/Swiss-Prot for TIMP4 Gene

  • Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9

Gene Wiki entry for TIMP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMP4 Gene

Genomics for TIMP4 Gene

Genomic Location for TIMP4 Gene

12,153,051 bp from pter
12,159,351 bp from pter
6,301 bases
Minus strand

Genomic View for TIMP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMP4 Gene

Regulatory Elements for TIMP4 Gene

Proteins for TIMP4 Gene

  • Protein details for TIMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloproteinase inhibitor 4
    Protein Accession:
    Secondary Accessions:
    • B2R7K6

    Protein attributes for TIMP4 Gene

    224 amino acids
    Molecular mass:
    25503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIMP4 Gene

Proteomics data for TIMP4 Gene at MOPED

Post-translational modifications for TIMP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMP4 Gene

Domains for TIMP4 Gene

Suggested Antigen Peptide Sequences for TIMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 NTR domain.:
    • Q99727
  • Belongs to the protease inhibitor I35 (TIMP) family.:
    • Q99727
genes like me logo Genes that share domains with TIMP4: view

No data available for Gene Families for TIMP4 Gene

Function for TIMP4 Gene

Molecular function for TIMP4 Gene

GENATLAS Biochemistry: matrix metalloproteinase,tissue inhibitor 4,abundantly expressed only in adult heart maybe embedded in intron V of SYN2
UniProtKB/Swiss-Prot Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9

Gene Ontology (GO) - Molecular Function for TIMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IBA --
GO:0005515 protein binding --
GO:0008191 metalloendopeptidase inhibitor activity NAS 8939999
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIMP4: view
genes like me logo Genes that share phenotypes with TIMP4: view

Animal Models for TIMP4 Gene

MGI Knock Outs for TIMP4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TIMP4 Gene

Localization for TIMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMP4 Gene


Subcellular locations from

Jensen Localization Image for TIMP4 Gene COMPARTMENTS Subcellular localization image for TIMP4 gene
Compartment Confidence
extracellular 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TIMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IBA --
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with TIMP4: view

Pathways for TIMP4 Gene

genes like me logo Genes that share pathways with TIMP4: view

Pathways by source for TIMP4 Gene

Gene Ontology (GO) - Biological Process for TIMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development IEA --
GO:0008150 biological_process ND --
GO:0009725 response to hormone IBA --
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with TIMP4: view

Compounds for TIMP4 Gene

(3) Novoseek inferred chemical compound relationships for TIMP4 Gene

Compound -log(P) Hits PubMed IDs
hydroxamate 52.2 1
1,10-phenanthroline 24.8 2
estrogen 0 2
genes like me logo Genes that share compounds with TIMP4: view

Transcripts for TIMP4 Gene

mRNA/cDNA for TIMP4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIMP4 Gene

TIMP metallopeptidase inhibitor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMP4 Gene

No ASD Table

Relevant External Links for TIMP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMP4 Gene

mRNA expression in normal human tissues for TIMP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIMP4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (10.6), Adipose - Subcutaneous (7.2), and Breast - Mammary Tissue (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIMP4 Gene

SOURCE GeneReport for Unigene cluster for TIMP4 Gene Hs.591665

mRNA Expression by UniProt/SwissProt for TIMP4 Gene

Tissue specificity: Abundant in heart and present at low levels in many other tissues
genes like me logo Genes that share expressions with TIMP4: view

Orthologs for TIMP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIMP4 35
  • 98.96 (n)
  • 99.11 (a)
TIMP4 36
  • 99 (a)
(Bos Taurus)
Mammalia TIMP4 35
  • 89.43 (n)
  • 90.18 (a)
TIMP4 36
  • 91 (a)
(Canis familiaris)
Mammalia TIMP4 35
  • 91.07 (n)
  • 91.96 (a)
TIMP4 36
  • 92 (a)
(Mus musculus)
Mammalia Timp4 35
  • 87.65 (n)
  • 88.84 (a)
Timp4 16
Timp4 36
  • 89 (a)
(Monodelphis domestica)
Mammalia TIMP4 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Timp4 35
  • 87.8 (n)
  • 89.73 (a)
(Gallus gallus)
Aves TIMP4 35
  • 76.05 (n)
  • 78.89 (a)
TIMP4 36
  • 76 (a)
(Anolis carolinensis)
Reptilia TIMP4 36
  • 68 (a)
(Danio rerio)
Actinopterygii TIMP4 36
  • 37 (a)
Species with no ortholog for TIMP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMP4 Gene

Gene Tree for TIMP4 (if available)
Gene Tree for TIMP4 (if available)

Paralogs for TIMP4 Gene

Paralogs for TIMP4 Gene

Selected SIMAP similar genes for TIMP4 Gene using alignment to 1 proteins: Pseudogenes for TIMP4 Gene

genes like me logo Genes that share paralogs with TIMP4: view

Variants for TIMP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TIMP4 Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
esv2724931 CNV Deletion 23290073
esv2193425 CNV Deletion 18987734
esv2724932 CNV Deletion 23290073
esv1007552 CNV Deletion 20482838
esv1015927 CNV Deletion 17803354
nsv236830 CNV Loss 16902084

Relevant External Links for TIMP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TIMP4 Gene

Disorders for TIMP4 Gene

(1) MalaCards Diseases for TIMP4 Gene

Search for TIMP4 Gene in MalaCards »

(14) Novoseek inferred disease relationships for TIMP4 Gene

Disease -log(P) Hits PubMed IDs
neovascularization 20.4 1
metastasis 19 3
breast cancer 13.5 11
tumors 11.2 18
arthritis 10.3 3

Relevant External Links for TIMP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TIMP4: view

No data available for UniProtKB/Swiss-Prot for TIMP4 Gene

Publications for TIMP4 Gene

  1. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. (PMID: 9693046) Olson T.M. … Apte S.S. (Genomics 1998) 2 3 4 23
  2. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. (PMID: 8939999) Greene J. … Shi Y.E. (J. Biol. Chem. 1996) 2 3 4 23
  3. Association of TIMP-4 gene polymorphism with the risk of osteoarthritis in the Korean population. (PMID: 18301898) Lee H.J. … Kim S. (Rheumatol. Int. 2008) 3 23 48
  4. Promoter polymorphism (rs3755724, -55C/T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean population. (PMID: 19048177) Ban J.Y. … Chung J.H. (Pediatr Cardiol 2009) 3 23 48
  5. Polymorphisms of MMP-3 and TIMP-4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients. (PMID: 19376102) Chen Q.J. … Shen W.F. (Clin. Chim. Acta 2009) 3 23 48

Products for TIMP4 Gene

Sources for TIMP4 Gene

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