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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMP4 Gene

protein-coding   GIFtS: 59
GCID: GC03M012169

TIMP metallopeptidase inhibitor 4

(Previous name: tissue inhibitor of metalloproteinase 4 )
 Explore 47 diseases affiliated with
TIMP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TIMP4    

Aliases
for TIMP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TIMP Metallopeptidase Inhibitor 41 2
Tissue Inhibitor Of Metalloproteinase 41 2
Tissue Inhibitor Of Metalloproteinases 42 3
TIMP-42 3
Metalloproteinase Inhibitor 42

External Ids:    HGNC: 118231   Entrez Gene: 70792   Ensembl: ENSG000001571507   OMIM: 6019155   UniProtKB: Q997273   

Export aliases for TIMP4 gene to outside databases

Previous GC identifers: GC03M012123 GC03M012038


Summaries
for TIMP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TIMP4:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix
metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin
domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and
may play role in hormonal regulation and endometrial tissue remodeling. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9

Gene Wiki entry for TIMP4


Genomic Views
for TIMP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMP4 gene promoter:
         E2F-4   E2F-3a   E2F-5   Lmo2   CUTL1   E2F-2   HNF-1A   E2F   E2F-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIMP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25

TIMP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMP4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M012169:  view genomic region     (about GC identifiers)

Start:
 12,194,551 bp from pter      End:
 12,200,851 bp from pter
Size:
 6,301 bases      Orientation:
 minus strand

Proteins
for TIMP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727 (See protein sequence)
Recommended Name: Metalloproteinase inhibitor 4 precursor  
Size: 224 amino acids; 25503 Da
Subcellular location: Secreted
Secondary accessions: B2R7K6

Explore the universe of human proteins at neXtProt for TIMP4: NX_Q99727

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99727

    • TIMP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003247.1  
    ENSEMBL proteins: 
     ENSP00000287814  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant TIMP4 Protein
    R&D Systems Recombinant & Natural Proteins for TIMP4 (TIMP-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TIMP4
    OriGene Custom Protein Services for TIMP4 
    GenScript Custom Purified and Recombinant Proteins Services for TIMP4
    Novus Biologicals TIMP4 Proteins
    Novus Biologicals TIMP4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TIMP4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005615extracellular space IEA--
    GO:0030017sarcomere IEA--


    TIMP4 for ontologies           About GeneDecksing



    TIMP4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TIMP4
    R&D Systems Antibodies for TIMP4 (TIMP-4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TIMP4 
    GenScript Custom Superior Antibodies Services for TIMP4
    Novus Biologicals TIMP4 Antibodies
    Search for Antibodies for TIMP4 at Abcam  
    Uscn Antibodies for TIMP4
    ThermoFisher Antibody for TIMP4

    Assay Products for TIMP4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for TIMP4 (TIMP-4)         (see all)
    GenScript Custom Assay Services for TIMP4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TIMP4

    Protein Domains /
    Families
    for TIMP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TIMP4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008993 TIMP-like_OB-fold
     IPR001134 Netrin_domain
     IPR015614 TIMP4
     IPR001820 Prot_inh_TIMP

    Graphical View of Domain Structure for InterPro Entry Q99727

    ProtoNet protein and cluster: Q99727

    1 Blocks protein family: IPB001820 Tissue inhibitor of metalloproteinase

    UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727
    Similarity: Belongs to the protease inhibitor I35 (TIMP) family
    Similarity: Contains 1 NTR domain


    Function
    for TIMP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727
    Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
    their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9

         Genatlas biochemistry entry for TIMP4:
    matrix metalloproteinase,tissue inhibitor 4,abundantly expressed only in adult heart maybe embedded in intron V of SYN2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TIMP4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP4:
    hsa-miR-892b hsa-miR-629* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: TIMP4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMP4 (see all 7)
    OriGene shRNA RFP: TIMP4
    OriGene siRNA: TIMP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TIMP4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMP4 (NM_003256)
    Sino Biological Human cDNA Clone for TIMP4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TIMP4
    Search LifeMap BioReagents cell lines for TIMP4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMP4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008191metalloendopeptidase inhibitor activity NAS8939999
    GO:0046872metal ion binding IEA--


    TIMP4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Timp4tm1Vuo for TIMP4
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Timp4):
     cardiovascular system  homeostasis/metabolism  mortality/aging 

    TIMP4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TIMP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TIMP4 (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Inhibition of Matrix Metalloproteinases
    Mitochondrial Apoptosis

    1 BioSystems Pathway for TIMP4 
        Matrix Metalloproteinases


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMP4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TIMP4 (Q997273 ENSP000002878144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    MMP14P502813, ENSP000003082084I2D: score=1 STRING: ENSP00000308208
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development IEA--
    GO:0008150biological_process ND--
    GO:0009725response to hormone stimulus ----
    GO:0032496response to lipopolysaccharide IEA--
    GO:0034097response to cytokine stimulus IEA--


    TIMP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TIMP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIMP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMP4
    3 Novoseek chemical compound relationships for TIMP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxamate 52.2 1 11415441 (1)
    1,10-phenanthroline 24.8 2 11415441 (1), 15013428 (1)
    estrogen 0 2 19700750 (1), 15273280 (1)

    Search CenterWatch for drugs/clinical trials and news about TIMP4 

    Transcripts
    for TIMP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TIMP4 gene: 
    NM_003256.3  

    Unigene Cluster for TIMP4:

    TIMP metallopeptidase inhibitor 4
    Hs.591665  [show with all ESTs]
    Unigene Representative Sequence: NM_003256
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000287814(uc003bwo.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TIMP4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP4:
    hsa-miR-892b hsa-miR-629* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: TIMP4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMP4 (see all 7)
    OriGene shRNA RFP: TIMP4
    OriGene siRNA: TIMP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMP4 (NM_003256)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMP4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMP4

    Additional cDNA sequence: 

    AK313018.1 BC010553.1 BT019627.1 U76456.1 

    1 DOTS entry:

    DT.308421 

    24/50 AceView cDNA sequences (see all 50):

    NM_003256 CD245370 BM707859 CA424098 AW292470 BM759178 AI637967 BU732949 
    BU615814 CD518333 AW963378 BX103242 BC010553 BP381456 BQ447036 BM740043 
    CD237468 AI671873 BI752578 AI080163 AW071635 CB142663 BG910254 AI671136 

    GeneLoc Exon Structure


    Expression
    for TIMP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATGGTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TIMP4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11) 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

    See TIMP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMP4

    SOURCE GeneReport for Unigene cluster: Hs.591665

    UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727
    Tissue specificity: Abundant in heart and present at low levels in many other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including TIMP4: 
              Fibrosis in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMP4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMP4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMP4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMP4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMP4

    Orthologs
    for TIMP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TIMP4 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Timp41 , 5 tissue inhibitor of metalloproteinase 41, 5 87.65(n)1
    88.84(a)1    		   6 (53.29 cM)5
    1105951  NM_080639.31  NP_542370.31 
     1152456165 
    chicken
    (Gallus gallus)    		 Aves TIMP41 TIMP metallopeptidase inhibitor 4 74.69(n)
    76.89(a)    		   768711  XM_001232058.2  XP_001232059.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TIMP46
    		 --
    		 70(a)
    		 1 ↔ 1
    		 2(158633586-158646263)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01061873.26
    		 --
    		 38(a)
    		 1 ↔ 1
    		 11(683264-691984)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Timp6
    		 Tissue inhibitor of metalloproteases
    		 20(a)
    		 1 → many
    		 3R(6029597-6038726)


    ENSEMBL Gene Tree for TIMP4 (if available)
    TreeFam Gene Tree for TIMP4 (if available) 

    Paralogs
    for TIMP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMP4 gene
    TIMP32  TIMP12  TIMP22  
    3 SIMAP similar genes for TIMP4 using alignment to 1 protein entry:     TIMP4_HUMAN:
    TIMP2    TIMP3    TIMP1

    TIMP4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TIMP4
    PGOHUM00000248421


    Genomic Variants
    for TIMP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TIMP4
         1 Inversion: 37239
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMP4
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMP4

    Disorders / Diseases
    for TIMP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TIMP4 for disorders           About GeneDecksing

    OMIM gene information: 601915    OMIM disorders: --

    20/47 diseases for TIMP4 (see all 47):    About MalaCards
    refractive error    congestive heart failure    arteriovenous malformation    corneal neovascularization
    gingival overgrowth    idiopathic pulmonary fibrosis    myocardial infarction    atrial fibrillation
    biliary atresia    acute myocardial infarction    diabetes, type 2    pulmonary fibrosis
    inflammatory bowel disease    ductal carcinoma in situ    atopic dermatitis    moyamoya disease
    renal cell carcinoma    kawasaki disease    adenomyosis    hyperhomocysteinemia

    10/14 Novoseek disease relationships for TIMP4 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 20.4 1 9791730 (1)
    metastasis 19 4 12828172 (2), 15523699 (1)
    breast cancer 13.5 15 12828172 (3), 11289097 (3), 11178975 (2), 9190892 (1) (see all 6)
    tumors 11.2 22 12798711 (3), 17873896 (2), 15713681 (2), 17009974 (2) (see all 12)
    arthritis 10.3 4 12483743 (3)
    cancer 9.71 9 17873896 (3), 15928670 (1), 9190892 (1), 18336787 (1) (see all 7)
    adenocarcinoma 8.16 3 17873896 (1), 12798711 (1), 11501766 (1)
    necrosis 5.4 2 15713681 (2)
    breast carcinoma 0 2 12828172 (1), 11178975 (1)
    inflammation 0 5 19450793 (2), 19036126 (1), 16521002 (1)

    Human Genome Epidemiology (HuGE) Navigator: TIMP4 (12 documents)

    Export disorders for TIMP4 gene to outside databases

    Publications
    for TIMP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMP4 gene, integrated from 9 sources (see all 129):
    (articles sorted by number of sources associating them with TIMP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. (PubMed id 9693046)1, 2, 3, 9 Olson T.M....Apte S.S. (1998)
    2. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. (PubMed id 8939999)1, 2, 3, 9 Greene J.... Shi Y.E. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2. (PubMed id 9182583)1, 9 Bigg H.F....Overall C.M. (1997)
    5. Endometrial TIMP-4 mRNA is expressed in the stroma, while TIMP-4 protein accumulates in the epithelium and is released to the uterine fluid. (PubMed id 16809379)1, 9 Pilka R....Casslen B. (2006)
    6. Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology. (PubMed id 16521002)1, 9 Koskivirta I....Jarvelainen H. (2006)
    7. Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets. (PubMed id 12466243)1, 9 Radomski A....Radomski M.W. (2002)
    8. Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4 serum levels, in patients with inflammatory bowel disease. (PubMed id 19036126)1, 9 Kapsoritakis A.N....Potamianos S.P. (2008)
    9. E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A). (PubMed id 12475252)1, 9 Troeberg L....Nagase H. (2002)
    10. Promoter Polymorphism (rs3755724, -55C/T) of Tissue Inhibitor of Metalloproteinase 4 (TIMP4) as a Risk Factor for Kawasaki Disease with Coronary Artery Lesions in a Korean Population. (PubMed id 19048177)1, 9 Ban J.Y....Chung J.H. (2008)

    External Searches for TIMP4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing TIMP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7079 HGNC: 11823 AceView: TIMP4 Ensembl:ENSG00000157150 euGenes: HUgn7079
    ECgene: TIMP4 H-InvDB: TIMP4

    Other Databases showing TIMP4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TIMP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMP4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TIMP4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TIMP4 gene:
    Search GeneIP for patents involving TIMP4

    GeneCards and IP:
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