Aliases for TIMP4 Gene
External Ids for TIMP4 Gene
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIMP4 Gene
TIMP4 (TIMP Metallopeptidase Inhibitor 4) is a Protein Coding gene. Diseases associated with TIMP4 include prostate cancer. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include metalloendopeptidase inhibitor activity. An important paralog of this gene is TIMP2.
UniProtKB/Swiss-Prot for TIMP4 Gene
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9