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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMP4 Gene

protein-coding   GIFtS: 59
GCID: GC03M012169

TIMP Metallopeptidase Inhibitor 4

(Previous name: tissue inhibitor of metalloproteinase 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TIMP Metallopeptidase Inhibitor 41 2
Tissue Inhibitor Of Metalloproteinase 41 2
Tissue Inhibitor Of Metalloproteinases 42 3
TIMP-42 3
Metalloproteinase Inhibitor 42

External Ids:    HGNC: 118231   Entrez Gene: 70792   Ensembl: ENSG000001571507   OMIM: 6019155   UniProtKB: Q997273   

Export aliases for TIMP4 gene to outside databases

Previous GC identifers: GC03M012123 GC03M012038


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIMP4 Gene:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix
metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted,
netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and
recruitment and may play role in hormonal regulation and endometrial tissue remodeling. (provided by RefSeq, Jul
2008)

GeneCards Summary for TIMP4 Gene: 
TIMP4 (TIMP metallopeptidase inhibitor 4) is a protein-coding gene. Diseases associated with TIMP4 include ductal carcinoma in situ, and adenomyosis, and among its related super-pathways are Inhibition of Matrix Metalloproteinases and Rac1 Pathway. GO annotations related to this gene include metalloendopeptidase inhibitor activity and metal ion binding. An important paralog of this gene is TIMP3.

UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9

Gene Wiki entry for TIMP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMP4 gene promoter:
         E2F-4   E2F-3a   E2F-5   Lmo2   CUTL1   E2F-2   HNF-1A   E2F   E2F-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25

TIMP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMP4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M012169:  view genomic region     (about GC identifiers)

Start:
12,194,551 bp from pter      End:
12,200,851 bp from pter
Size:
6,301 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727 (See protein sequence)
Recommended Name: Metalloproteinase inhibitor 4 precursor  
Size: 224 amino acids; 25503 Da
Subcellular location: Secreted
Secondary accessions: B2R7K6

Explore the universe of human proteins at neXtProt for TIMP4: NX_Q99727

Explore proteomics data for TIMP4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99727

  • TIMP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMP4 Protein Expression
    REFSEQ proteins: NP_003247.1  
    ENSEMBL proteins: 
     ENSP00000287814  

    Human Recombinant Protein Products for TIMP4: 
    EMD Millipore Purified and/or Recombinant TIMP4 Protein
    R&D Systems Recombinant & Natural Proteins for TIMP4 (TIMP-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TIMP4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TIMP4
    GenScript Custom Purified and Recombinant Proteins Services for TIMP4
    Novus Biologicals TIMP4 Proteins
    Novus Biologicals TIMP4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIMP4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005615extracellular space IEA--
    GO:0030017sarcomere IEA--

    TIMP4 for ontologies           About GeneDecksing



    TIMP4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TIMP4
    R&D Systems Antibodies for TIMP4 (TIMP-4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TIMP4
    GenScript Custom Superior Antibodies Services for TIMP4
    Novus Biologicals TIMP4 Antibodies
    Abcam antibodies for TIMP4
    Cloud-Clone Corp. Antibodies for TIMP4 
    ThermoFisher Antibody for TIMP4
    LSBio Antibodies in human, mouse, rat for TIMP4 

    Assay Products for TIMP4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TIMP4
    R&D Systems ELISAs for TIMP4 (TIMP-4)         (see all)
    GenScript Custom Assay Services for TIMP4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIMP4 
    Cloud-Clone Corp. CLIAs for TIMP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR008993 TIMP-like_OB-fold
     IPR027465 TIMP_C_dom
     IPR001134 Netrin_domain
     IPR015614 TIMP4
     IPR001820 Prot_inh_TIMP

    Graphical View of Domain Structure for InterPro Entry Q99727

    ProtoNet protein and cluster: Q99727

    1 Blocks protein domain: IPB001820 Tissue inhibitor of metalloproteinase

    UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727
    Similarity: Belongs to the protease inhibitor I35 (TIMP) family
    Similarity: Contains 1 NTR domain


    TIMP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIMP4_HUMAN, Q99727
    Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
    their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9

         Genatlas biochemistry entry for TIMP4:
    matrix metalloproteinase,tissue inhibitor 4,abundantly expressed only in adult heart maybe embedded in intron V of
    SYN2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008191metalloendopeptidase inhibitor activity NAS8939999
    GO:0046872metal ion binding IEA--
         
    TIMP4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Timp4):
     cardiovascular system  homeostasis/metabolism  mortality/aging 

    TIMP4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Timp4tm1Vuo for TIMP4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMP4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMP4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMP4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP4:
    hsa-miR-892b hsa-miR-629* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTIMP4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMP4
    Sirion Biotech Customized adenovirus for overexpression of TIMP4

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TIMP4 (see all 7)
    OriGene ORF clones in mouse, rat for TIMP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMP4 (NM_003256)
    Sino Biological Human cDNA Clone for TIMP4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP4
    Sirion Biotech Customized lentivirus for stable overexpression of TIMP4 
                         Customized lentivirus expression plasmids for stable overexpression of TIMP4 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TIMP4
    Search LifeMap BioReagents cell lines for TIMP4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMP4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIMP4 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TIMP4 (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Inhibition of Matrix Metalloproteinases
    Mitochondrial Apoptosis

    1 BioSystems Pathway for TIMP4
        Matrix Metalloproteinases



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMP4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TIMP4 (Q997273 ENSP000002878144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    MMP14P502813, ENSP000003082084I2D: score=1 STRING: ENSP00000308208
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development IEA--
    GO:0008150biological_process ND--
    GO:0009725response to hormone stimulus ----
    GO:0032496response to lipopolysaccharide IEA--
    GO:0034097response to cytokine stimulus IEA--

    TIMP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIMP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMP4

    3 Novoseek inferred chemical compound relationships for TIMP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxamate 52.2 1 11415441 (1)
    1,10-phenanthroline 24.8 2 11415441 (1), 15013428 (1)
    estrogen 0 2 19700750 (1), 15273280 (1)

    Search CenterWatch for drugs/clinical trials and news about TIMP4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMP4 gene: 
    NM_003256.3  

    Unigene Cluster for TIMP4:

    TIMP metallopeptidase inhibitor 4
    Hs.591665  [show with all ESTs]
    Unigene Representative Sequence: NM_003256
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000287814(uc003bwo.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP4:
    hsa-miR-892b hsa-miR-629* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTIMP4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP4
    Clone
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    OriGene clones in human, mouse for TIMP4 (see all 7)
    OriGene ORF clones in mouse, rat for TIMP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMP4 (NM_003256)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP4
    Sirion Biotech Customized lentivirus for stable overexpression of TIMP4 
                         Customized lentivirus expression plasmids for stable overexpression of TIMP4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIMP4
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMP4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMP4

    Additional mRNA sequence: 

    AK313018.1 BC010553.1 BT019627.1 U76456.1 

    1 DOTS entry:

    DT.308421 

    24/50 AceView cDNA sequences (see all 50):

    BU615814 CD245370 AW963378 NM_003256 AW292470 CA424098 AI637967 BP381456 
    CD518333 BM707859 BC010553 BU732949 BX103242 BM759178 CB992438 BF346229 
    AI634427 AI080163 U76456 AW293304 BQ447036 AW196583 BE788008 CB995893 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMP4 expression in normal human tissues (normalized intensities)      TIMP4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATGGTATA
    TIMP4 Expression
    About this image


    TIMP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 13 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             Normal Human Articular chondrocytes (NHAC)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 7 entries
             HyStem+BMP4-induced E15 cells
             Human Preadipocyte-visceral (HPA-v)   
             omental adipose tissue   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Medulla Oblongata
             Human Brain Vascular Pericyte (HBVP)   
             cerebellum   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Mesencephalic Ventricular Zone

    See TIMP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMP4

    SOURCE GeneReport for Unigene cluster: Hs.591665

    UniProtKB/Swiss-Prot: TIMP4_HUMAN, Q99727
    Tissue specificity: Abundant in heart and present at low levels in many other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including TIMP4: 
              Fibrosis in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TIMP4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TIMP4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timp41 , 5 tissue inhibitor of metalloproteinase 41, 5 87.65(n)1
    88.84(a)1
      6 (53.29 cM)5
    1105951  NM_080639.31  NP_542370.31 
     1152456165 
    chicken
    (Gallus gallus)
    Aves TIMP41 TIMP metallopeptidase inhibitor 4 74.69(n)
    76.89(a)
      768711  XM_001232058.2  XP_001232059.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIMP46
    Uncharacterized protein
    69(a)
    1 ↔ 1
    2(158631331-158646263)
    zebrafish
    (Danio rerio)
    Actinopterygii TIMP46
    TIMP metallopeptidase inhibitor 4
    37(a)
    1 ↔ 1
    11(683264-691984)
    fruit fly
    (Drosophila melanogaster)
    Insecta Timp6
    Tissue inhibitor of metalloproteases
    20(a)
    1 → many
    3R(6029597-6038726)


    ENSEMBL Gene Tree for TIMP4 (if available)
    TreeFam Gene Tree for TIMP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMP4 gene
    TIMP32  TIMP12  TIMP22  
    3 SIMAP similar genes for TIMP4 using alignment to 1 protein entry:     TIMP4_HUMAN:
    TIMP2    TIMP3    TIMP1

    TIMP4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TIMP4
    PGOHUM00000248421


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TIMP4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1007552CNV Deletion20482838
    dgv850e199CNV Deletion23128226
    dgv810e201CNV Deletion23290073
    esv1015927CNV Deletion17803354
    esv2193425CNV Deletion18987734
    esv2724932CNV Deletion23290073
    esv2724931CNV Deletion23290073
    nsv236830CNV Loss16902084
    nsv7351OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMP4
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601915    OMIM disorders: --

    20/42 diseases for TIMP4 (see all 42):    About MalaCards
    ductal carcinoma in situ    adenomyosis    moyamoya disease    idiopathic pulmonary fibrosis
    corneal neovascularization    congestive heart failure    refractive error    arteriovenous malformation
    diabetes, type 2    biliary atresia    gingival overgrowth    kawasaki disease
    prostate cancer, progression of    gingivitis    hyperhomocysteinemia    pulmonary fibrosis
    atopic dermatitis    acute myocardial infarction    prostate cancer    pheochromocytoma


    TIMP4 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for TIMP4 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 20.4 1 9791730 (1)
    metastasis 19 4 12828172 (2), 15523699 (1)
    breast cancer 13.5 15 12828172 (3), 11289097 (3), 11178975 (2), 9190892 (1) (see all 6)
    tumors 11.2 22 12798711 (3), 17873896 (2), 15713681 (2), 17009974 (2) (see all 12)
    arthritis 10.3 4 12483743 (3)
    cancer 9.71 9 17873896 (3), 15928670 (1), 9190892 (1), 18336787 (1) (see all 7)
    adenocarcinoma 8.16 3 17873896 (1), 12798711 (1), 11501766 (1)
    necrosis 5.4 2 15713681 (2)
    breast carcinoma 0 2 12828172 (1), 11178975 (1)
    inflammation 0 5 19450793 (2), 19036126 (1), 16521002 (1)

    Genetic Association Database (GAD): TIMP4
    Human Genome Epidemiology (HuGE) Navigator: TIMP4 (12 documents)

    Export disorders for TIMP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMP4 gene, integrated from 9 sources (see all 131):
    (articles sorted by number of sources associating them with TIMP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. (PubMed id 9693046)1, 2, 3, 9 Olson T.M....Apte S.S. (1998)
    2. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. (PubMed id 8939999)1, 2, 3, 9 Greene J.... Shi Y.E. (1996)
    3. Promoter Polymorphism (rs3755724, -55C/T) of Tissue Inhibitor of Metalloproteinase 4 (TIMP4) as a Risk Factor for Kawasaki Disease with Coronary Artery Lesions in a Korean Population. (PubMed id 19048177)1, 4, 9 Ban J.Y....Chung J.H. (2008)
    4. Polymorphisms of MMP-3 and TIMP-4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients. (PubMed id 19376102)1, 4, 9 Chen Q.J....Shen W.F. (2009)
    5. Association of TIMP-4 gene polymorphism with the risk of osteoarthritis in the Korean population. (PubMed id 18301898)1, 4, 9 Lee H.J....Kim S. (2008)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Interferon gamma receptor 2 gene variants are associa ted with liver fibrosis in patients with chronic hepatitis C infection. (PubMed id 20587546)1, 4 Nalpas B....Abel L. (2010)
    8. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    9. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    10. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7079 HGNC: 11823 AceView: TIMP4 Ensembl:ENSG00000157150 euGenes: HUgn7079
    ECgene: TIMP4 H-InvDB: TIMP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMP4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMP4 gene:
    Search GeneIP for patents involving TIMP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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