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TIMP3 Gene

protein-coding   GIFtS: 63

GC22P031521
TIMP metallopeptidase inhibitor 3
(Previous names: tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SFD)
Services    

Aliases &
Descriptions
for TIMP3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
HSMRK222 2
K222 2
K222TA2 2
SFD 2, 5
TIMP-3 3
Descriptions
MIG-5 protein 2
Protein MIG-5 3
TIMP metallopeptidase inhibitor 3 2
Tissue inhibitor of metalloproteinases 3 3
tissue inhibitor of metalloproteinase 3 2
tissue inhibitor of metalloproteinase 3 (Sorsby fundus
dystrophy, pseudoinflammatory) 1
External Ids
HGNC: 118221
Entrez Gene: 70782
UniProtKB: P356253
Ensembl: ENSG000001002347
Search outside databases for aliases for TIMP3 gene

Previous GC identifer: GC22P029893

Summaries
for TIMP3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for TIMP3:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors
of the matrix metalloproteinases, a group of peptidases involved in degradation of the
extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic
stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this
gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
[provided by RefSeq]

UniProtKB/Swiss-Prot: TIMP3_HUMAN, P35625
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates
them. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on
MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15

Gene Wiki entry for TIMP3

Genomic Location
for TIMP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TIMP3 gene  

Entrez Gene cytogenetic band: 22q12.1-q13.2|22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

TIMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031521:     (about GC identifiers)

Start:
 31,526,802 bp from pter
End:
 31,589,030 bp from pter
Size:
 62,229 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  

Proteins
for TIMP3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TIMP3_HUMAN, P35625 (See protein sequence)
Recommended Name: Metalloproteinase inhibitor 3 precursor  
Size: 211 amino acids; 24145 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
PDB structures from and Proteopedia :
3CKI (3D)    
Secondary accessions: Q5THV4 Q9UC74 Q9UGS2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_000353.1  

    ENSEMBL proteins: 
    ENSP00000371481 ENSP00000266085 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for TIMP3  
    R&D Systems Recombinant & Natural Proteins for TIMP3 (TIMP-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TIMP3)
    Human Recombinant Proteins from Abnova (TIMP3)
                  OriGene Purified Recombinant Human Protein: TIMP3 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005604 basement membrane IEA--
    About this table

    Antibodies for TIMP3: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of TIMP3
    Sigma-Aldrich Antibodies for TIMP3
    R&D Systems Antibodies for TIMP3 (TIMP-3)
    Antibodies from Abcam (TIMP3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TIMP3)
    Novus Biologicals Antibodies for TIMP3

    Assays for TIMP3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    R&D Systems ELISAs for TIMP3 (TIMP-3)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for TIMP3

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR001134 Netrin_domain
     IPR015612 Tissue_inhib_metalloprotease_3
     IPR001820 Prot_inh_TIMP


       GeneDecks  TIMP3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P35625

    ProtoNet protein and cluster: P35625

    1 Blocks protein family: IPB001820 Tissue inhibitor of metalloproteinase

    UniProtKB/Swiss-Prot: TIMP3_HUMAN, P35625
    Similarity: Belongs to the protease inhibitor I35 (TIMP) family
    Similarity: Contains 1 NTR domain

    Gene Function
    for TIMP3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TIMP3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000362

                  Applied Biosystems Silencer® siRNAs for TIMP3

                  Sigma-Aldrich siRNA and siRNA Panels for TIMP3  
                         Sigma-Aldrich shRNA Panels and shRNA for TIMP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TIMP3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000362
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000362
                                     untagged cDNA clone in CMV expression vector: NM_000362 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000362

    UniProtKB/Swiss-Prot: TIMP3_HUMAN, P35625
    Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates
    them. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on
    MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15

    Genatlas biochemistry entry for TIMP3:
    matrix metalloproteinase,tissue inhibitor 3,expressed in retinal pigment
    epithelium,placenta,localized in extracellular matrix (glycosylated or not form),embedded in
    intron V of SYN3,inactivated by methylation in uterus,breast,renal,colon,brain carcinomas

    15/17 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Timp3) (see all 17 ):

    behavior/neurologicalcellularendocrine/exocrine glandgrowth/size
    hematopoietic systemhomeostasis/metabolismimmune systemlife span-post-weaning/agingliver/biliary system
    musclepigmentationrenal/urinary systemreproductive systemrespiratory system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857 enzyme inhibitor activity IEA--
    GO:0005515 protein binding IPI18344519
    GO:0008191 metalloendopeptidase inhibitor activity IEA--
    About this table

    Pathways & Interactions
    for TIMP3

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for TIMP3
     Cell adhesion ECM remodeling

       GeneDecks  TIMP3 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  TIMP3  (Your Favorite Gene powered by Ingenuity) 
     Oncostatin M Signaling
     Leukocyte Extravasation Signaling

       GeneDecks  TIMP3 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  TIMP3 


    5/70 Interacting proteins for TIMP3 (P356251 ENSP000002660853) via UniProtKB, MINT, and/or STRING (see all 70 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTR2P500521, ENSP000003609733EBI-1748085, EBI-1748067 STRING (score=.742)
    ADAM17ENSP000003099683STRING (score=.994)
    MMP2ENSP000002190703STRING (score=.986)
    TP53ENSP000002693053STRING (score=.986)
    MMP9ENSP000003614053STRING (score=.984)
    About this table

    5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS15609325
    GO:0007601 visual perception IEA--
    GO:0014070 response to organic cyclic substance IEA--
    GO:0042246 tissue regeneration IEA--
    GO:0043627 response to estrogen stimulus IEA--
    About this table

    Drugs & Compounds
    for TIMP3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TIMP3
    10/26 Novoseek chemical compound relationships for TIMP3 gene (see all 26 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adamalysin 69.76 1 15095265 (1)
    o6-methylguanine 48.95 5 12845678 (1), 16502411 (1), 14654977 (1), 15197802 (1) (see all 5)
    tgf beta1 40.42 7 15599946 (3), 11869079 (3), 15883123 (1)
    matrigel 38.95 1 9622064 (1)
    tetrahydrofolate 23.88 3 16981189 (1)
    progesterone 20.53 8 9160717 (2), 7588231 (1), 11344207 (1), 17033924 (1) (see all 6)
    ribonucleic acid 17.48 2 9589682 (2)
    glycosaminoglycan 16.43 3 14587283 (2), 11817583 (1)
    pd 98,059 8.87 4 15743030 (1), 9794437 (1), 15468069 (1)
    lipid 2.17 1 10711711 (1)
    About this table


    Transcripts
    for TIMP3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TIMP3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000362

                  Sigma-Aldrich siRNA and siRNA Panels for TIMP3  
                         Sigma-Aldrich shRNA Panels and shRNA for TIMP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000362  

    REFSEQ mRNAs for TIMP3 gene: 

    NM_000362.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000362  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000362
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000362
                                     untagged cDNA clone in CMV expression vector: NM_000362 

    Additional cDNA sequence: 

    AF035289.1 AK098517.1 AK298126.1 AK311702.1 AK314871.1 BC014277.2 BT006848.1 CR456593.1 
    CR591532.1 CR593019.1 CR593372.1 CR593651.1 CR594502.1 CR594958.1 CR595883.1 CR595938.1 
    CR596287.1 CR597142.1 CR602193.1 CR603101.1 CR604843.1 CR605518.1 CR607327.1 CR608290.1 
    CR609852.1 CR609959.1 CR610281.1 CR613064.1 CR613128.1 CR613233.1 CR613766.1 CR615393.1 
    CR615534.1 CR616306.1 CR617133.1 CR617989.1 CR619079.1 CR620436.1 CR620838.1 CR621505.1 
    CR623084.1 CR624342.1 CR625842.1 CR625847.1 CR625951.1 D45917.1 L15078.1 S78453.1 
    U02571.1 U14394.1 U67195.1 X76227.1 X77690.1 X80791.1 

    24/55 DOTS entries (see all 55 ):

    DT.100045220  DT.95100610  DT.95100669  DT.91646034  DT.100829527  DT.95237947  DT.95316138  DT.100830114 
    DT.100893513  DT.100893530  DT.100893475  DT.101977541  DT.120661402  DT.95100608  DT.100893483  DT.100893520 
    DT.100893534  DT.100893490  DT.100893503  DT.100893508  DT.91707000  DT.100893485  DT.100765761  DT.100771946 

    24/1504 AceView cDNA sequences (see all 1504 ):

    BP346421 BM999265 AA330848 BP345616 BQ018545 BI053176 AW518922 CR613128 
    BX347839 BQ882578 AA297325 AA043121 AA340549 CR613064 BE503072 BF724200 
    BQ924223 BX509183 CA950691 CA397974 AI085924 BP345057 CD246078 AI753733 

    highest scoring ESTs for TIMP3:

    U14394 AA037049 AA040164 AA040626 AA044304 AA120801 AA127881 AA190453 AA191396 AA192345 

    Unigene Cluster for TIMP3:

    TIMP metallopeptidase inhibitor 3
    Hs.644633  [show with all ESTs]
    Unigene Representative Sequence: NM_000362


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000382049  ENST00000266085  

    Expression
    for TIMP3

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TIMP3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TIMP3

    1 / 2 / 3

    10 probe-sets matching TIMP3 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1034_at2, 3 U95-A 1 1.00 1.00 0.93 1.00 U14394 1.00 1.00 1.00 1
    1035_g_at2, 3 U95-A 1 1.00 1.00 0.96 1.00 U14394 1.00 1.00 1.00 1

    		201149_s_at2, 3 U133-A 1 1.00 1.00 -- -- U67195 0.80 1.00 0.91 1

    		201150_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000362 0.60 1.00 0.82 1

    		201147_s_at2, 3 U133-A 1 1.00 1.00 -- -- BF347089 0.80 0.88 0.84 1

    		201148_s_at2, 3 U133-A 4 1.00 0.93 -- -- AW338933 0.80 0.88 0.84 1

    		201149_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		201150_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		201147_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		201148_s_at2 U133Plus2 4 1.00 0.93 -- -- -- -- -- -- --
    GeneDecks  TIMP3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTATTTATGA

    SOURCE GeneReport for Unigene cluster: Hs.644633

    Expression variation in blood from EXPOLDB for TIMP3

    Orthologs
    for TIMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TIMP3 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 TIMP31   -- TIMP metallopeptidase inhibitor 3 93.68(n)
    99.05(a)    		 481289  XM_538410.2  XP_538410.2 
    chimpanzee
    (Pan troglodytes)    		 TIMP31   -- TIMP metallopeptidase inhibitor 3 99.37(n)
    100(a)    		 458784  XM_515097.2  XP_515097.2 
    cow
    (Bos taurus)    		 TIMP31   -- TIMP metallopeptidase inhibitor 3 93.84(n)
    98.1(a)    		 282094  NM_174473.3  NP_776898.2 
    rat
    (Rattus norvegicus)    		 Timp31   -- TIMP metallopeptidase inhibitor 3 89.89(n)
    95.26(a)    		 25358  NM_012886.2  NP_037018.2 
    mouse
    (Mus musculus)    		 Timp31, 5 10 (47.00 cM)5
    		 tissue inhibitor of metalloproteinase 31, 5 89.73(n)1
    96.21(a)1    		 218591  NM_011595.21  NP_035725.11 
     AB0416115  AK0839055  (see all 24)
    About this table        Species with no ortholog for TIMP3

    ENSEMBL Gene Tree for TIMP3

    Paralogs
    for TIMP3

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TIMP3 gene
    TIMP42  TIMP12  TIMP22  

    SNPs/Variants
    for TIMP3

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for TIMP3

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 188826   disorders: 136900  

    UniProtKB/Swiss-Prot: TIMP3_HUMAN, P35625

  • Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a
    rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is
    characterized by loss of central vision from subretinal neovascularization and atrophy of the
    ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6
    months to 6 years

    • 10/97 Novoseek disease relationships for TIMP3 gene (see all 97 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    drusen 65.79 7 11878827 (2), 11450763 (1), 10476804 (1), 12391305 (1) (see all 5)
    choroidal dystrophy central areolar 60.09 1 9152224 (1)
    macular dystrophy, vitelliform 59.58 2 17491602 (1), 9152224 (1)
    tumors 57.73 181 9164653 (5), 16186800 (4), 15714128 (4), 17032447 (4) (see all 94)
    night blindness 50.66 1 7550309 (1)
    cancer 48.43 55 17032447 (4), 10188875 (4), 18516293 (4), 15467768 (3) (see all 30)
    choroidal neovascularization 44.85 5 8759363 (1), 12652295 (1), 9006347 (1), 9112976 (1)
    maculopathy 43.74 1 9643018 (1)
    metastasis 43.51 31 15467768 (3), 17657847 (3), 12828172 (2), 12629131 (2) (see all 21)
    blindness 39.04 5 7920634 (1), 10854443 (1), 12372614 (1), 9112976 (1) (see all 5)
    About this table

    Human Gene Mutation Database: TIMP3
    Genetic Association Database: TIMP3
    Human Genome Epidemiology Navigator: TIMP3 (12 documents)

    Medical News
    for TIMP3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for TIMP3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/545 PubMed articles for TIMP3 gene (see all 545 ):

    Search for TIMP3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TIMP3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 7078 HGNC: 11822 AceView: TIMP3 Ensembl:ENSG00000100234 euGenes: HUgn7078
    ECgene: TIMP3 H-InvDB: TIMP3

    Other Databases showing TIMP3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing TIMP3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for TIMP3 Genetics and Cytogenetics in Oncology and Haematology
    Mutations of the TIMP3 genehttp://www.retina-international.com/sci-news/timpmut.htm
    GeneReviewshttp://www.genetests.org/query?gene=TIMP3

    Licensable Technologies
    for TIMP3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for TIMP3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TIMP3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TIMP3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TIMP3 Antibodies for TIMP3
     Explore super-pooled esiRNAs Proteins for TIMP3
     Lentivirus-delivered shRNAs for TIMP3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
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