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TIMP2 Gene

protein-coding GIFtS: 68

GC17M074363

TIMP metallopeptidase inhibitor 2
(Previous name: tissue inhibitor of metalloproteinase 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CSC-21K ^¹, ², ³
TIMP-2 ^³

Descriptions
TIMP metallopeptidase inhibitor 2 ^²
Tissue inhibitor of metalloproteinases 2 ^², ³
tissue inhibitor of metalloproteinase 2 ^¹, ²

External Ids
HGNC: 11821¹
Entrez Gene: 7077²
UniProtKB: P16035³
Ensembl: ENSG00000035862⁷

Search outside databases for aliases for TIMP2 gene

Previous GC identifers: GC17M076623 GC17M080115 GC17M077310 GC17M077446

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TIMP2:

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural

inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the

extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded

protein has a unique role among TIMP family members in its ability to directly suppress the

proliferation of endothelial cells. As a result, the encoded protein may be critical to the

maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in

response to angiogenic factors, and by inhibiting protease activity in tissues undergoing

remodelling of the extracellular matrix. [provided by RefSeq]

UniProtKB/Swiss-Prot: TIMP2_HUMAN, P16035

Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates

them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15,

MMP-16 and MMP-19

Gene Wiki entry for TIMP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TIMP2 gene

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25

TIMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M074363: (about GC identifiers)

Start:	74,360,654 bp from pter
End:	74,433,067 bp from pter
Size:	72,414 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TIMP2_HUMAN, P16035 (See protein sequence)

Recommended Name: Metalloproteinase inhibitor 2 precursor

Size: 220 amino acids; 24399 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1BR9 (3D)

1GXD (3D)

2TMP (3D)

Secondary accessions: Q16121 Q93006 Q9UDF7

Post-translational modifications:

The activity of TIMP2 is dependent on the presence of disulfide bonds¹

REFSEQ proteins: NP_003246.1

ENSEMBL proteins:

ENSP00000262768

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant TIMP2 Protein
	Sigma-Aldrich Proteins for TIMP2
	R&D Systems Recombinant & Natural Proteins for TIMP2 (TIMP-2)
	Enzo Life Sciences proteins for TIMP2
	Recombinant Proteins from Abcam (TIMP2)
	Human Recombinant Proteins from Abnova (TIMP2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005604	basement membrane	IEA	--
GO:0009986	cell surface	IEA	--

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Antibodies for TIMP2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TIMP2
	Sigma-Aldrich Antibodies for TIMP2
	R&D Systems Antibodies for TIMP2 (TIMP-2)
	Antibodies from Abcam (TIMP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TIMP2)
	Novus Biologicals Antibodies for TIMP2

Assays for TIMP2:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of TIMP2
	R&D Systems ELISAs for TIMP2 (TIMP-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P16035

ProtoNet protein and cluster: P16035

1 Blocks protein family: IPB001820 Tissue inhibitor of metalloproteinase

UniProtKB/Swiss-Prot: TIMP2_HUMAN, P16035

Similarity: Belongs to the protease inhibitor I35 (TIMP) family

Similarity: Contains 1 NTR domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TIMP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TIMP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003255

Applied Biosystems Silencer® siRNAs for TIMP2

Sigma-Aldrich siRNA for TIMP2

Sigma-Aldrich shRNA Panels and shRNA for TIMP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TIMP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003255
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003255
untagged cDNA clones in CMV expression vector (see all 2): AL713764

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003255

UniProtKB/Swiss-Prot: TIMP2_HUMAN, P16035

Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates

them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15,

MMP-16 and MMP-19

Genatlas biochemistry entry for TIMP2:

matrix metalloproteinase,tissue inhibitor 2,with two alternatively spliced forms may be associated

with SYN4,involved in the invasive phenotype of acute myelogenous leukemia

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Timp2):

behavior/neurological	hematopoietic system	homeostasis/metabolism	immune system	nervous system
normal

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004857	enzyme inhibitor activity	IEA	--
GO:0005178	integrin binding	IEA	--
GO:0005515	protein binding	IPI	17353931
GO:0008047	enzyme activator activity	IEA	--
GO:0008191	metalloendopeptidase inhibitor activity	TAS	8810321

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TIMP2 (Your Favorite Gene powered by Ingenuity)

Hepatic Fibrosis / Hepatic Stellate Cell Activation
Leukocyte Extravasation Signaling

GeneDecks TIMP2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TIMP2

5/30 Interacting proteins for TIMP2 (P16035¹ ENSP00000262768³) via UniProtKB, MINT, and/or STRING (see all 30 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMA7	O14818¹	EBI-1033507, EBI-603272
SNCG	O76070¹	EBI-1033507, EBI-1053810
MMP14	ENSP00000308208³	STRING (score=.999)
MMP2	ENSP00000219070³	STRING (score=.999)
MMP15	ENSP00000219271³	STRING (score=.966)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008285	negative regulation of cell proliferation	IEA	--
GO:0030814	regulation of cAMP metabolic process	IEA	--
GO:0043408	regulation of MAPKKK cascade	IEA	--
GO:0045664	regulation of neuron differentiation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TIMP2
10/45 Novoseek chemical compound relationships for TIMP2 gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	74.71	15	8740587 (2), 14606648 (2), 18474097 (1), 9462715 (1) (see all 9)
(4-aminophenyl)mercuric acetate	66.44	2	1646720 (1), 7772054 (1)
norcantharidin	54.05	8	16784656 (3), 16681930 (3)
methyl selenol	45.96	2	16702316 (2)
hydroxamate	40.85	14	8086430 (2), 9733724 (2), 12475252 (1), 11415441 (1) (see all 7)
ribonucleic acid	31.77	1	9661630 (1)
1,10-phenanthroline	31.14	6	1655733 (1), 10551322 (1), 11415441 (1), 15095267 (1) (see all 5)
sorbinil	25.99	1	9328936 (1)
12-o-tetradecanoylphorbol 13-acetate	24.98	1	1284126 (1)
beta-ionone	22.69	5	14716815 (3), 16229269 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TIMP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TIMP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003255

Sigma-Aldrich siRNA for TIMP2

Sigma-Aldrich shRNA Panels and shRNA for TIMP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003255

REFSEQ mRNAs for TIMP2 gene:

NM_003255.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003255

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003255
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003255
                                 untagged cDNA clones in CMV expression vector (see all 2): AL713764

Additional cDNA sequence:

AK294290.1 AL110197.1 AL713764.1 BC010410.2 BC039613.1 BC040039.1 BC040445.1 BC052605.1

BC071586.1 BC111089.1 CR596527.1 CR612157.1 CR613160.1 CR616844.1 CR621263.1 J05593.1

M32304.1 S48568.1 X54533.1

24/26 DOTS entries (see all 26 ):

DT.100884685 DT.320454 DT.101958961 DT.100039281 DT.100039279 DT.91780826 DT.91964592 DT.120897367

DT.87011688 DT.95260462 DT.95351132 DT.100884682 DT.120897375 DT.91780931 DT.120897359 DT.95242885

DT.100884683 DT.100884688 DT.120897281 DT.91686177 DT.95260440 DT.102844632 DT.120897324 DT.120897333

24/869 AceView cDNA sequences (see all 869 ):

BX374543 AW071939 CA389182 BG542006 C01506 AI383725 BM721909 AI446177

BM705378 CA413513 AW261831 BM705526 AW874577 CD516597 AI766105 AA947693

AI338229 BE877280 BM997448 CF125784 BM142286 BF437567 T35759 AW005791

highest scoring ESTs for TIMP2:

BQ877420 AL045993 BC052605 BC071586 BF726476 BG031482 BG897306 BQ675802 BQ679628 BQ889497

Unigene Cluster for TIMP2:

TIMP metallopeptidase inhibitor 2

Hs.633514 [show with all ESTs]

Unigene Representative Sequence: NM_003255

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TIMP2

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d
SP1:			-		-		-		-										-
SP2:																			-
SP3:
SP4:																			-
SP5:					-		-		-

About this scheme

ECgene alternative splicing isoforms for TIMP2

1 Ensembl transcript including schematic representation:

ENST00000262768

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TIMP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TIMP2

¹ / ² / ³

10 probe-sets matching TIMP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1375_s_at²^{, 3}	U95-A	1	1.00	1.00	0.79	0.94	M32304	0.80	0.88	0.84	1
34722_at²^{, 3}	U95-A	1	1.00	1.00	-0.40	0.92	U44385	0.20	1.00	0.72	1
49080_at²^{, 3}	U95-C	1	1.00	1.00	0.84	1.65	AL042923	0.60	1.00	0.82	1
73079_at²^{, 3}	U95-D	2	1.00	0.50	0.07	0.52	AI867422	0.60	0.83	0.73	1
231579_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE968786	0.20	1.00	0.72	1
203167_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003255	0.60	1.00	0.82	1
224560_at²^{, 3}	U133-B	2	1.00	0.95	--	--	BF107565	0.40	1.00	0.76	1
231579_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203167_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224560_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks TIMP2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTCTGATGC

SOURCE GeneReport for Unigene cluster: Hs.633514
Expression variation in blood from EXPOLDB for TIMP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TIMP2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TIMP2¹	--	TIMP metallopeptidase inhibitor 2	92.27(n) 96.36(a)	403633 NM_001003082.1 NP_001003082.1
cow (Bos taurus)	TIMP2¹	--	TIMP metallopeptidase inhibitor 2	91.67(n) 91.82(a)	282093 NM_174472.3 NP_776897.2
rat (Rattus norvegicus)	Timp2¹	--	TIMP metallopeptidase inhibitor 2	91.97(n) 98.18(a)	29543 NM_021989.2 NP_068824.1
mouse (Mus musculus)	Timp2^{1, 5}	11 (72.00 cM)⁵	tissue inhibitor of metalloproteinase 2^{1, 5}	91.97(n)¹ 98.18(a)¹	21858¹ NM_011594.3¹ NP_035724.2¹ AI426775⁵ AI850047⁵ (see all 35)
zebrafish (Danio rerio)	timp2²	--	tissue inhibitor of metalloproteinase 2	81.31(n)	359835 AY324194.1

About this table Species with no ortholog for TIMP2

ENSEMBL Gene Tree for TIMP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TIMP2 gene

TIMP4² TIMP3² TIMP1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/644 NCBI SNPs in TIMP2 are shown (see all 644 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 154)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs8179091^1,2	A,C,F,H	74433385(-)	`TGGTGC/TCCTGG`	1	--	ng3¹		6		NS EU EA WA	432
	rs8080623^1,2	A,C,F,H	74433873(+)	`TGAAGA/GGATGA`	1	--	ng3¹		12		EU EA WA	1258
	rs4789933^1,2	A,C,F,H	74435021(-)	`AAAACA/GATGAA`	1	--	ng3¹		7		EU EA WA NA	554
	rs7405712^1,2	C,H	74434746(+)	`TGTGCG/AGTGCT`	1	--	ng3¹		4		EU EA WA	416
--	rs8179093^1,2	C,F	74433359(-)	`GTCCCA/CCGCGC`	1	--	ng3¹		2		NS	20
--	rs7503726^1,2	C,F	74433026(+)	`TGCGGC/TTCTCG`	1	--	ut5¹ ese³		2		NS	20
	rs3809892^1,2	F,H	74361046(-)	`TATATA/GTAGTT`	1	--	ut3¹ ese³		4		EU EA WA	416
--	rs7503607^1,2	C,F	74433034(+)	`TCGGCG/TGCCGC`	1	--	ut5¹ ese³		2		NS	20
--	rs8179092^1,2	F	74433370(-)	`ACGGGG/-CGCGA`	1	--	ng3¹		2		NS	20
--	rs8068093^1,2	C	74434702(+)	`ttgttG/Tttttt`	1	--	ng3¹ trp³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for TIMP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 188825

10/93 Novoseek disease relationships for TIMP2 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	71.24	157	15946567 (4), 16114547 (4), 10425288 (4), 15546163 (4) (see all 83)
tumors	62.97	348	8674034 (6), 15546163 (6), 16784992 (5), 10366463 (5) (see all 99)
fibrosarcoma	56.85	9	16214327 (2), 18495463 (1), 8112602 (1), 2380196 (1) (see all 8)
cancer	52.04	72	9008095 (3), 9484825 (3), 11796838 (3), 11890687 (3) (see all 46)
conjunctivochalasis	49.24	3	10670469 (2)
liver fibrosis	47.77	19	9792032 (3), 11925608 (3), 14695775 (3), 18217401 (2) (see all 7)
pathological processes	47.61	2	10985804 (1), 11004090 (1)
carcinoma	42.59	64	15781321 (5), 12970394 (5), 15095267 (4), 8302724 (3) (see all 30)
carcinoma squamous cell	41.76	20	12479097 (2), 10657012 (1), 16142392 (1), 18042068 (1) (see all 12)
aortic aneurysm abdominal	41.60	1	10372551 (1)

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Human Gene Mutation Database: TIMP2
Genetic Association Database: TIMP2
Human Genome Epidemiology Navigator: TIMP2 (29 documents)
Tumor Gene Database: TIMP2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/940 PubMed articles for TIMP2 gene (see all 940 ):

Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. (PubMed id 1730286)^{1, 3, 4} Osthues A.... Tschesche H. (1992)
Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. (PubMed id 2380196)^{1, 3, 4} Stetler-Stevenson W.G.... Liotta L.A. (1990)
The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer. (PubMed id 16275157)^{1, 3, 6} O-Charoenrat P. and Khantapura P. (2006)
Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. (PubMed id 14604886)^{1, 3, 6} Zhou Y....Lin D. (2004)
Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. (PubMed id 14605322)^{1, 3, 6} Krex D....Schackert G. (2003)
Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene. (PubMed id 8810321)^{1, 3, 4} Hammani K.... Declerck Y.A. (1996)
Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2). (PubMed id 8112602)^{1, 3, 4} de Clerck Y.A.... Rousseau G.G. (1994)
Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis. (PubMed id 15691353)^{3, 6} de Souza A.P....Line S.R. (2005)
Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians. (PubMed id 15672858)^{3, 6} Hegab A.E....Sekizawa K. (2005)
Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)^{3, 6} Ogata T....Kuivaniemi H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7077	HGNC: 11821	AceView: TIMP2	Ensembl:ENSG00000035862	euGenes: HUgn7077
ECgene: TIMP2	H-InvDB: TIMP2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TIMP2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TIMP2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TIMP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TIMP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TIMP2		Antibodies for TIMP2
	Explore super-pooled esiRNAs		Proteins for TIMP2
	Lentivirus-delivered shRNAs for TIMP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TIMP2)
	Antibodies (TIMP2)
	Chimera RNAi (TIMP2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TIMP2)
	Antibodies (TIMP2)

Search OriGene for TIMP2

Search Tocris compounds for TIMP2

	Proteins for TIMP2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TIMP2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TIMP2 Gene at Home site.
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TIMP2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for TIMP2

Summaries
for TIMP2

Genomic Location
for TIMP2

Proteins
for TIMP2

Protein Domains/
Families
for TIMP2

Gene Function
for TIMP2

Pathways & Interactions
for TIMP2

Drugs & Compounds
for TIMP2

Transcripts
for TIMP2

Expression
for TIMP2

Orthologs
for TIMP2

Paralogs
for TIMP2

SNPs/Variants
for TIMP2

Disorders & Mutations
for TIMP2

Medical News
for TIMP2

Publications
for TIMP2

Search for TIMP2

Genome Databases showing TIMP2

Other Databases showing TIMP2

Specialized Databases showing TIMP2

Licensable Technologies
for TIMP2

Services
for TIMP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TIMP2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor TIMP2

Summariesfor TIMP2

Genomic Locationfor TIMP2

Proteinsfor TIMP2

Protein Domains/Familiesfor TIMP2

Gene Functionfor TIMP2

Pathways & Interactionsfor TIMP2

Drugs & Compoundsfor TIMP2

Transcriptsfor TIMP2

Expression for TIMP2

Orthologsfor TIMP2

Paralogsfor TIMP2

SNPs/Variantsfor TIMP2

Disorders & Mutationsfor TIMP2

Medical Newsfor TIMP2

Publicationsfor TIMP2

Search for TIMP2

Genome Databases showing TIMP2

Other Databases showing TIMP2

Specialized Databases showing TIMP2

Licensable Technologiesfor TIMP2

Servicesfor TIMP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TIMP2

Summaries
for TIMP2

Genomic Location
for TIMP2

Proteins
for TIMP2

Protein Domains/
Families
for TIMP2

Gene Function
for TIMP2

Pathways & Interactions
for TIMP2

Drugs & Compounds
for TIMP2

Transcripts
for TIMP2

Expression
for TIMP2

Orthologs
for TIMP2

Paralogs
for TIMP2

SNPs/Variants
for TIMP2

Disorders & Mutations
for TIMP2

Medical News
for TIMP2

Publications
for TIMP2

Licensable Technologies
for TIMP2

Services
for TIMP2