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Aliases for TIMP2 Gene

Aliases for TIMP2 Gene

  • TIMP Metallopeptidase Inhibitor 2 2 3 5
  • Tissue Inhibitor Of Metalloproteinases 2 3 4
  • CSC-21K 3 4
  • Tissue Inhibitor Of Metalloproteinase 2 2
  • Testicular Secretory Protein Li 57 3
  • Metalloproteinase Inhibitor 2 3
  • TIMP-2 4
  • DDC8 3

External Ids for TIMP2 Gene

Previous GeneCards Identifiers for TIMP2 Gene

  • GC17M076623
  • GC17M080115
  • GC17M077310
  • GC17M077446
  • GC17M074363
  • GC17M076850
  • GC17M072271

Summaries for TIMP2 Gene

Entrez Gene Summary for TIMP2 Gene

  • This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIMP2 Gene

TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a Protein Coding gene. Diseases associated with TIMP2 include Conjunctivochalasis and Lipodermatosclerosis. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include integrin binding and enzyme activator activity. An important paralog of this gene is TIMP4.

UniProtKB/Swiss-Prot for TIMP2 Gene

  • Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Gene Wiki entry for TIMP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMP2 Gene

Genomics for TIMP2 Gene

Regulatory Elements for TIMP2 Gene

Enhancers for TIMP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G078878 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +42.7 42675 9.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 BRCA1 ZNF48 ZNF121 ZNF766 GLIS2 USP36 TIMP2 CYTH1 CANT1 ENGASE PIR59444 ENSG00000279339
GH17G078875 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +49.2 49150 2.4 KLF1 PKNOX1 SUZ12 NFIB SIN3A FEZF1 FOSL1 ZFHX2 ZNF366 SCRT2 TIMP2 USP36 PGS1 CANT1 CYTH1 PIR59444 GC17P078863
GH17G078284 1 Ensembl ENCODE 5.6 +640.5 640458 1.6 PAF1 NFIB ZNF10 CEBPB MAX CEBPG ZIC2 THRB RARA ZFHX2 LINC01993 TIMP2 LOC105371912
GH17G078932 2 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -9.3 -9296 4.5 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 FOS C1QTNF1 ENSG00000267491 CEP295NL CANT1 TIMP2 GC17P078963
GH17G078960 1.5 Ensembl ENCODE dbSUPER 0.3 -36.9 -36898 3.0 FOXA2 ARID4B FEZF1 TCF12 SP5 ZHX2 MXD4 PPARG KAT8 SMARCA4 GC17P078963 TIMP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIMP2 on UCSC Golden Path with GeneCards custom track

Promoters for TIMP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098998 490 2201 TBP PKNOX1 ARID4B SIN3A RAD21 GLIS2 ZNF366 KLF7 EGR2 SP3

Genomic Location for TIMP2 Gene

Chromosome:
17
Start:
78,852,977 bp from pter
End:
78,925,390 bp from pter
Size:
72,414 bases
Orientation:
Minus strand

Genomic View for TIMP2 Gene

Genes around TIMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMP2 Gene

Proteins for TIMP2 Gene

  • Protein details for TIMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16035-TIMP2_HUMAN
    Recommended name:
    Metalloproteinase inhibitor 2
    Protein Accession:
    P16035
    Secondary Accessions:
    • Q16121
    • Q93006
    • Q9UDF7

    Protein attributes for TIMP2 Gene

    Size:
    220 amino acids
    Molecular mass:
    24399 Da
    Quaternary structure:
    • Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

    Three dimensional structures from OCA and Proteopedia for TIMP2 Gene

neXtProt entry for TIMP2 Gene

Post-translational modifications for TIMP2 Gene

  • The activity of TIMP2 is dependent on the presence of disulfide bonds.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMP2 Gene

Assay Products

  • Cloud-Clone Corp Assay Kits for TIMP2

No data available for DME Specific Peptides for TIMP2 Gene

Domains & Families for TIMP2 Gene

Gene Families for TIMP2 Gene

Suggested Antigen Peptide Sequences for TIMP2 Gene

Graphical View of Domain Structure for InterPro Entry

P16035

UniProtKB/Swiss-Prot:

TIMP2_HUMAN :
  • Belongs to the protease inhibitor I35 (TIMP) family.
Family:
  • Belongs to the protease inhibitor I35 (TIMP) family.
genes like me logo Genes that share domains with TIMP2: view

Function for TIMP2 Gene

Molecular function for TIMP2 Gene

GENATLAS Biochemistry:
matrix metalloproteinase,tissue inhibitor 2,with two alternatively spliced forms may be associated with SYN4,involved in the invasive phenotype of acute myelogenous leukemia
UniProtKB/Swiss-Prot Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 9573338
GO:0004857 enzyme inhibitor activity IEA --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 24112707
GO:0008191 metalloendopeptidase inhibitor activity IDA,IEA 9573338
genes like me logo Genes that share ontologies with TIMP2: view
genes like me logo Genes that share phenotypes with TIMP2: view

Animal Models for TIMP2 Gene

MGI Knock Outs for TIMP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TIMP2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMP2 Gene

Localization for TIMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMP2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IBA --
GO:0009986 cell surface IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with TIMP2: view

Pathways & Interactions for TIMP2 Gene

genes like me logo Genes that share pathways with TIMP2: view

Gene Ontology (GO) - Biological Process for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development IEA --
GO:0007568 aging IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009725 response to hormone IBA --
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with TIMP2: view

No data available for SIGNOR curated interactions for TIMP2 Gene

Drugs & Compounds for TIMP2 Gene

(48) Drugs for TIMP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(40) Additional Compounds for TIMP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIMP2: view

Transcripts for TIMP2 Gene

Unigene Clusters for TIMP2 Gene

TIMP metallopeptidase inhibitor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: -
SP3:
SP4: -
SP5: - - -

Relevant External Links for TIMP2 Gene

GeneLoc Exon Structure for
TIMP2
ECgene alternative splicing isoforms for
TIMP2

Expression for TIMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMP2 Gene

mRNA differential expression in normal tissues according to GTEx for TIMP2 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for TIMP2 Gene

This gene is overexpressed in Amniocyte (39.0) and Serum (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMP2 Gene



Protein tissue co-expression partners for TIMP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMP2 Gene:

TIMP2

SOURCE GeneReport for Unigene cluster for TIMP2 Gene:

Hs.633514

Evidence on tissue expression from TISSUES for TIMP2 Gene

  • Skin(4.9)
  • Nervous system(4.7)
  • Lung(4.3)
  • Eye(4.1)
  • Heart(4.1)
  • Pancreas(3.9)
  • Muscle(3.3)
  • Blood(3)
  • Kidney(3)
  • Bone(2.9)
  • Liver(2.8)
  • Lymph node(2.8)
  • Gall bladder(2.7)
  • Intestine(2.7)
  • Spleen(2.4)
  • Stomach(2.2)
  • Adrenal gland(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with TIMP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMP2 Gene

Orthologs for TIMP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMP2 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia TIMP2 34 35
  • 92.27 (n)
mouse
(Mus musculus)
Mammalia Timp2 34 16 35
  • 91.97 (n)
rat
(Rattus norvegicus)
Mammalia Timp2 34
  • 91.97 (n)
cow
(Bos Taurus)
Mammalia TIMP2 34 35
  • 91.67 (n)
oppossum
(Monodelphis domestica)
Mammalia TIMP2 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIMP2 34 35
  • 79.63 (n)
lizard
(Anolis carolinensis)
Reptilia TIMP2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timp2 34
  • 77.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26350 34
zebrafish
(Danio rerio)
Actinopterygii timp2a 34 35
  • 75.8 (n)
timp2b 35
  • 50 (a)
OneToMany
timp2 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4143 34
Species where no ortholog for TIMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMP2 Gene

ENSEMBL:
Gene Tree for TIMP2 (if available)
TreeFam:
Gene Tree for TIMP2 (if available)

Paralogs for TIMP2 Gene

Paralogs for TIMP2 Gene

(4) SIMAP similar genes for TIMP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TIMP2: view

Variants for TIMP2 Gene

Sequence variations from dbSNP and Humsavar for TIMP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000001586 -- 78,918,553(+) CGCCT(C/T)CCCTC intron-variant
rs1000021645 -- 78,903,335(+) GCTCA(A/G)GCAGC intron-variant, upstream-variant-2KB
rs1000052083 -- 78,926,947(+) AGAGG(C/T)GGAGG upstream-variant-2KB
rs1000056290 -- 78,924,200(+) CGGAG(A/G)TCATG intron-variant
rs1000058962 -- 78,923,218(+) GCGCT(A/G)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMP2 Gene

Variant ID Type Subtype PubMed ID
esv2031325 CNV deletion 18987734
esv2667094 CNV deletion 23128226
esv3554834 CNV deletion 23714750
nsv1057193 CNV gain 25217958
nsv1066843 CNV gain 25217958
nsv1070850 CNV deletion 25765185
nsv1112717 CNV deletion 24896259
nsv1118771 CNV deletion 24896259
nsv1134680 CNV deletion 24896259
nsv457917 CNV gain 19166990
nsv576101 CNV gain 21841781
nsv952376 CNV deletion 24416366
nsv952377 CNV deletion 24416366

Variation tolerance for TIMP2 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMP2 Gene

Human Gene Mutation Database (HGMD)
TIMP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMP2 Gene

Disorders for TIMP2 Gene

MalaCards: The human disease database

(32) MalaCards diseases for TIMP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
conjunctivochalasis
lipodermatosclerosis
  • acute lipodermatosclerosis
abdominal aortic aneurysm
  • aortic aneurysm, familial abdominal 1
inguinal hernia
  • hernia inguinal
microcystic meningioma
- elite association - COSMIC cancer census association via MalaCards
Search TIMP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIMP2

Genetic Association Database (GAD)
TIMP2
Human Genome Epidemiology (HuGE) Navigator
TIMP2
Tumor Gene Database (TGDB):
TIMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMP2
genes like me logo Genes that share disorders with TIMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIMP2 Gene

Publications for TIMP2 Gene

  1. Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer. (PMID: 18674955) Vairaktaris E. … Patsouris E. (Oral Oncol. 2009) 3 22 46 64
  2. Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. (PMID: 19889076) Hung K.H. … Sheu B.S. (Helicobacter 2009) 3 22 46 64
  3. TIMP-2 gene polymorphism is associated with intracerebral hemorrhage. (PMID: 19844095) Reuter B. … Fatar M. (Cerebrovasc. Dis. 2009) 3 22 46 64
  4. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. (PMID: 2380196) Stetler-Stevenson W.G. … Liotta L.A. (J. Biol. Chem. 1990) 3 4 22 64
  5. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans G.H. … . (N. Engl. J. Med. 2011) 3 46 64

Products for TIMP2 Gene

Sources for TIMP2 Gene

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