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TIMP2 Gene

protein-coding   GIFtS: 69
GCID: GC17M076850

TIMP Metallopeptidase Inhibitor 2

(Previous name: tissue inhibitor of metalloproteinase 2)
  See TIMP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TIMP Metallopeptidase Inhibitor 21 2     TIMP-22 3
Tissue Inhibitor Of Metalloproteinase 21 2     DDC82
Tissue Inhibitor Of Metalloproteinases 22 3     Metalloproteinase Inhibitor 22
CSC-21K2 3     

External Ids:    HGNC: 118211   Entrez Gene: 70772   Ensembl: ENSG000000358627   OMIM: 1888255   UniProtKB: P160353   

Export aliases for TIMP2 gene to outside databases

Previous GC identifers: GC17M076623 GC17M080115 GC17M077310 GC17M077446 GC17M074363 GC17M072271


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIMP2 Gene:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of
the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In
addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP
family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the
encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of
quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing
remodelling of the extracellular matrix. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIMP2 Gene:
TIMP2 (TIMP metallopeptidase inhibitor 2) is a protein-coding gene. Diseases associated with TIMP2 include microcystic meningioma, and gingival hypertrophy. GO annotations related to this gene include metalloendopeptidase inhibitor activity and integrin binding. An important paralog of this gene is TIMP4.

UniProtKB/Swiss-Prot: TIMP2_HUMAN, P16035
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14,
MMP-15, MMP-16 and MMP-19

Gene Wiki entry for TIMP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIMP2 gene promoter:
         Sp1   p53   AP-1   AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   ATF   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMP2 promoter sequence
   Search Chromatin IP Primers for TIMP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

TIMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076850:  view genomic region     (about GC identifiers)

Start:
76,849,059 bp from pter      End:
76,921,472 bp from pter
Size:
72,414 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TIMP2_HUMAN, P16035 (See protein sequence)
Recommended Name: Metalloproteinase inhibitor 2 precursor  
Size: 220 amino acids; 24399 Da
Subunit: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the
MMP2 activity
4 PDB 3D structures from and Proteopedia for TIMP2:
1BR9 (3D)        1GXD (3D)        2TMP (3D)        4ILW (3D)    
Secondary accessions: Q16121 Q93006 Q9UDF7

Explore the universe of human proteins at neXtProt for TIMP2: NX_P16035

Explore proteomics data for TIMP2 at MOPED

Post-translational modifications: 

  • The activity of TIMP2 is dependent on the presence of disulfide bonds1
  • Modification sites at neXtProt

  • See TIMP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003246.1  
    ENSEMBL proteins: 
     ENSP00000467584   ENSP00000441724   ENSP00000262768   ENSP00000468296   ENSP00000464930  
    Reactome Protein details: P16035

    TIMP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TIMP2 (TIMP-2)
    Enzo Life Sciences proteins for TIMP2
    OriGene Purified Protein for TIMP2
    OriGene Protein Over-expression Lysate for TIMP2
    OriGene MassSpec for TIMP2
    OriGene Custom Protein Services for TIMP2
    GenScript Custom Purified and Recombinant Proteins Services for TIMP2
    Novus Biologicals TIMP2 Proteins
    Novus Biologicals TIMP2 Lysates
    Sino Biological Recombinant Protein for TIMP2
    Sino Biological Cell Lysate for TIMP2
    ProSpec Recombinant Protein for TIMP2
    Cloud-Clone Corp. Proteins for TIMP2

     
    Search eBioscience for Proteins for TIMP2 

     
    antibodies-online proteins for TIMP2 (31 products) 

     
    antibodies-online peptides for TIMP2

    TIMP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TIMP2
    R&D Systems Antibodies for TIMP2 (TIMP-2)
    Cell Signaling Technology (CST) Antibodies for TIMP2 
    OriGene Antibodies for TIMP2
    OriGene Custom Antibody Services for TIMP2
    Novus Biologicals TIMP2 Antibodies
    Abcam antibodies for TIMP2
    Cloud-Clone Corp. Antibodies for TIMP2
    ThermoFisher Antibody for TIMP2
    antibodies-online antibodies for TIMP2 (193 products) 

    TIMP2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of TIMP2
    OriGene Custom Assay Services for TIMP2
    R&D Systems ELISAs for TIMP2 (TIMP-2)         (see all)
    GenScript Custom Assay Services for TIMP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIMP2
    Cloud-Clone Corp. CLIAs for TIMP2
    Search eBioscience for ELISAs for TIMP2 
    antibodies-online kits for TIMP2 (44 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR008993 TIMP-like_OB-fold
     IPR027465 TIMP_C_dom
     IPR015613 TIMP2
     IPR001134 Netrin_domain
     IPR001820 Prot_inh_TIMP

    Graphical View of Domain Structure for InterPro Entry P16035

    ProtoNet protein and cluster: P16035

    1 Blocks protein domain: IPB001820 Tissue inhibitor of metalloproteinase

    UniProtKB/Swiss-Prot: TIMP2_HUMAN, P16035
    Similarity: Belongs to the protease inhibitor I35 (TIMP) family
    Similarity: Contains 1 NTR domain


    Find genes that share domains with TIMP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIMP2_HUMAN, P16035
    Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
    their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14,
    MMP-15, MMP-16 and MMP-19
    Induction: Down-regulated by TGFB1

         Genatlas biochemistry entry for TIMP2:
    matrix metalloproteinase,tissue inhibitor 2,with two alternatively spliced forms may be associated with
    SYN4,involved in the invasive phenotype of acute myelogenous leukemia

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI--
    GO:0008047enzyme activator activity IEA--
    GO:0008191metalloendopeptidase inhibitor activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TIMP2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TIMP2:
     Increased cell death in HCT116  Increased focal adhesion (FA)   Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Timp2):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     normal 

    Find genes that share phenotypes with TIMP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TIMP2: Timp2tm1Jjc Timp2tm1Pds

       genOway: Develop your customized and physiologically relevant rodent model for TIMP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIMP2:
    hsa-mir-519c-3p (MIRT006639), hsa-mir-519d-3p (MIRT006198)

    Block miRNA regulation of human, mouse, rat TIMP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIMP2 (see all 71):
    hsa-miR-631 hsa-miR-106a hsa-miR-30d hsa-miR-519a hsa-miR-3161 hsa-miR-3142 hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTIMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIMP2
    Predesigned siRNA for gene silencing in human, mouse, rat TIMP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMP2

    Clone
    Products:
         
    OriGene clones in human, mouse for TIMP2 (see all 7)
    OriGene ORF clones in mouse, rat for TIMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMP2 (NM_003255)
    Sino Biological Human cDNA Clone for TIMP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIMP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TIMP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIMP2_HUMAN, P16035: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    plasma membrane2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IEA--
    GO:0009986cell surface IEA--
    GO:0030426growth cone IEA--

    Find genes that share ontologies with TIMP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TIMP2 About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Activation of Matrix Metalloproteinases0.37
    Inhibition of Matrix Metalloproteinases0.68
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with TIMP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TIMP2 (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Inhibition of Matrix Metalloproteinases
    Mitochondrial Apoptosis

    2 Cell Signaling Technology (CST) Pathways for TIMP2
        Angiogenesis
    Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for TIMP2
        Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling

    2 BioSystems Pathways for TIMP2
        Angiogenesis
    Matrix Metalloproteinases


    1 Reactome Pathway for TIMP2
        Activation of Matrix Metalloproteinases


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TIMP2 (see all 8): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TIMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIMP2 (P160351, 3 ENSP000002627684) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP14P502811, 3, ENSP000003082084EBI-1033507,EBI-992788 I2D: score=3 STRING: ENSP00000308208
    MMP2P082533, ENSP000002190704I2D: score=4 STRING: ENSP00000219070
    PSMA7O148183, ENSP000003599104I2D: score=2 STRING: ENSP00000359910
    ECHS1P300843, ENSP000003575354I2D: score=1 STRING: ENSP00000357535
    HSPA4LO957573, ENSP000002964644I2D: score=1 STRING: ENSP00000296464
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    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development IEA--
    GO:0007568aging IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0010951negative regulation of endopeptidase activity TAS8810321
    GO:0022617extracellular matrix disassembly TAS--

    Find genes that share ontologies with TIMP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIMP2

    Selected Novoseek inferred chemical compound relationships for TIMP2 gene (see all 88)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 75.1 17 8740587 (2), 14606648 (2), 18474097 (1), 9462715 (1) (see all 11)
    batimastat 73.6 15 17086359 (2), 7563189 (2), 15949468 (1), 10551322 (1) (see all 12)
    (4-aminophenyl)mercuric acetate 65.5 2 1646720 (1), 7772054 (1)
    vegf 54.6 85 16202678 (4), 16681930 (4), 19787153 (3), 12225633 (2) (see all 51)
    norcantharidin 51.1 8 16784656 (3), 16681930 (3)
    methyl selenol 43.8 2 16702316 (2)
    hydroxamate 38.9 14 8086430 (2), 9733724 (2), 12475252 (1), 11415441 (1) (see all 7)
    latanoprost 37.1 6 14638715 (2), 12454040 (1), 18971237 (1), 16936101 (1) (see all 5)
    paraffin 30.5 6 20209790 (1), 16776850 (1), 16784656 (1), 16169261 (1) (see all 6)
    ribonucleic acid 30.1 1 9661630 (1)



    Find genes that share compounds with TIMP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIMP2 gene: 
    NM_003255.4  

    Unigene Cluster for TIMP2:

    TIMP metallopeptidase inhibitor 2
    Hs.633514  [show with all ESTs]
    Unigene Representative Sequence: NM_003255
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585421 ENST00000536189 ENST00000262768(uc002jwe.3 uc010wty.2 uc002jwf.3)
    ENST00000586057 ENST00000592761
    miRNA
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    Block miRNA regulation of human, mouse, rat TIMP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIMP2 (see all 71):
    hsa-miR-631 hsa-miR-106a hsa-miR-30d hsa-miR-519a hsa-miR-3161 hsa-miR-3142 hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTIMP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TIMP2
    Predesigned siRNA for gene silencing in human, mouse, rat TIMP2
    Clone
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    OriGene clones in human, mouse for TIMP2 (see all 7)
    OriGene ORF clones in mouse, rat for TIMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMP2 (NM_003255)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP2
    Primer
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    OriGene qPCR primer pairs and template standards for TIMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMP2
      QuantiTect SYBR Green Assays in human, mouse, rat TIMP2
      QuantiFast Probe-based Assays in human, mouse, rat TIMP2

    Additional mRNA sequence: 

    AK294290.1 AL110197.1 AL713764.1 BC010410.2 BC039613.1 BC040039.1 BC040445.1 BC052605.1 
    BC071586.1 BC111089.1 J05593.1 M32304.1 S48568.1 X54533.1 

    23 DOTS entries:

    DT.100884685  DT.320454  DT.101958961  DT.100039281  DT.100039279  DT.91780826  DT.91964592  DT.87011688 
    DT.91780931  DT.120897359  DT.95260462  DT.100884682  DT.120897375  DT.95242885  DT.100884683  DT.100884688 
    DT.102844632  DT.120897333  DT.91686177  DT.95260440  DT.120897324  DT.95125209  DT.95260451 

    Selected AceView cDNA sequences (see all 869):

    R97102 BQ423425 BE968429 AA401237 BQ230902 BQ877351 AA034334 BM978025 
    CA310164 AW872745 CF125784 BU951495 BI261040 AI888363 AI758724 BG540365 
    BM999817 AW071939 F03539 CA447101 AW498792 BX282533 T35759 T34709 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TIMP2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d
    SP1:        -     -     -     -                             -                           
    SP2:                                                        -                           
    SP3:                                                                                    
    SP4:                                                        -                           
    SP5:              -     -     -                                                         


    ECgene alternative splicing isoforms for TIMP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TIMP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTGATGC
    TIMP2 Expression
    About this image


    TIMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 32) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Oligodendrocyte-like cells
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             Odontoblasts Dentin
             Dentin
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Stylopod Long Bone
             Bone marrow-derived mesenchymal stem cells
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
    TIMP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIMP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.633514
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TIMP2 (see all 8): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TIMP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timp21 , 5 tissue inhibitor of metalloproteinase 21, 5 91.97(n)1
    98.18(a)1
      11 (83.09 cM)5
    218581  NM_011594.31  NP_035724.21 
     1183010695 
    chicken
    (Gallus gallus)
    Aves TIMP21 TIMP metallopeptidase inhibitor 2 79.63(n)
    81.82(a)
      374178  NM_204298.1  NP_989629.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIMP26
    TIMP metallopeptidase inhibitor 2
    85(a)
    1 ↔ 1
    2(101738132-101774039)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.263502 Xenopus laevis transcribed sequence with moderate similarity more 76.11(n)    CF548190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii timp22 tissue inhibitor of metalloproteinase 2 81.31(n)   359835  AY324194.1 


    ENSEMBL Gene Tree for TIMP2 (if available)
    TreeFam Gene Tree for TIMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIMP2 gene
    TIMP42  TIMP32  TIMP12  
    4 SIMAP similar genes for TIMP2 using alignment to 3 protein entries:     TIMP2_HUMAN (see all proteins):
    LOC100653515    TIMP4    TIMP3    TIMP1

    Find genes that share paralogs with TIMP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIMP2 (see all 1499)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844374891,2
    --76848571(+) GCCCCA/GTCTCT 1 -- ds50010--------
    rs1460421931,2
    --76848582(+) GCCACC/TGCATC 1 -- ds50010--------
    rs1478239471,2
    --76848590(+) ATCGCA/GCTTTT 1 -- ds50010--------
    rs1424645821,2
    --76848698(+) CCTCCA/GAGGTT 1 -- ds50010--------
    rs1465223611,2
    --76848762(+) CACCAC/TGCCTA 1 -- ds50010--------
    rs1483161951,2
    --76848788(+) GGGTTA/TTGCGA 1 -- ds50010--------
    rs1414267331,2
    --76848792(+) TTTGCA/GAAGTT 1 -- ds50010--------
    rs72182011,2
    C--76848899(+) GCATCC/ACATAT 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1903662751,2
    --76848936(+) TCTCTA/GGAGGA 1 -- ds50010--------
    rs1503902171,2
    --76848959(+) CCTCCC/TGCCGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TIMP2 (76849059 - 76921472 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TIMP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667094CNV Deletion23128226
    esv2031325CNV Deletion18987734
    dgv3283n71CNV Loss21882294
    nsv908894CNV Loss21882294
    dgv3284n71CNV Loss21882294
    nsv908900CNV Loss21882294
    dgv3282n71CNV Loss21882294
    nsv457917CNV Gain19166990

    Human Gene Mutation Database (HGMD): TIMP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188825    OMIM disorders: --

    13 diseases for TIMP2:    
    About MalaCards
    microcystic meningioma    gingival hypertrophy    conjunctivochalasis    rheumatic heart disease
    vulvar intraepithelial neoplasia    lung giant cell carcinoma    hereditary neuralgic amyotrophy    arteriovenous fistula
    varicose veins    exfoliation syndrome    cervical squamous cell carcinoma    moyamoya disease
    spinal stenosis

    3 diseases from the University of Copenhagen DISEASES database for TIMP2:
    Carcinoma     Vascular disease     Arthritis

    Find genes that share disorders with TIMP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TIMP2 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 70.7 160 15946567 (4), 16114547 (4), 10425288 (4), 15546163 (4) (see all 86)
    tumors 63.1 367 8674034 (6), 15546163 (6), 16784992 (5), 10366463 (5) (see all 99)
    fibrosarcoma 56.8 14 16214327 (2), 18495463 (1), 8112602 (1), 7768948 (1) (see all 9)
    cancer 51.4 81 9008095 (3), 9484825 (3), 11796838 (3), 11890687 (3) (see all 49)
    liver fibrosis 51.2 24 19517234 (5), 9792032 (3), 11925608 (3), 14695775 (3) (see all 8)
    pathological processes 46.3 2 10985804 (1), 11004090 (1)
    conjunctivochalasis 45.7 3 10670469 (2)
    aortic aneurysm abdominal 43.1 1 10372551 (1)
    carcinoma 41.6 67 15781321 (5), 12970394 (5), 15095267 (4), 8302724 (3) (see all 31)
    carcinoma squamous cell 41.1 22 12479097 (2), 10657012 (1), 16142392 (1), 18042068 (1) (see all 14)

    Genetic Association Database (GAD): TIMP2
    Human Genome Epidemiology (HuGE) Navigator: TIMP2 (54 documents)
    Tumor Gene Database (TGDB): TIMP2

    Export disorders for TIMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIMP2 gene, integrated from 10 sources (see all 1178):
    (articles sorted by number of sources associating them with TIMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer. (PubMed id 17236757)1, 4, 9 Wu C.Y....Lin J.T. (Eur. J. Cancer 2007)
    2. TIMP-2 gene polymorphism is associated with intracerebral hemorrhage. (PubMed id 19844095)1, 4, 9 Reuter B....Fatar M. (Cerebrovasc. Dis. 2009)
    3. MMP-2, MMP-9 and TIMP-2 gene polymorphisms in Chinese patients with generalized aggressive periodontitis. (PubMed id 17448043)1, 4, 9 Chen D....Wu Z.F. (J. Clin. Periodontol. 2007)
    4. Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. (PubMed id 1730286)1, 2, 9 Osthues A.... Tschesche H. (FEBS Lett. 1992)
    5. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. (PubMed id 2380196)1, 2, 9 Stetler-Stevenson W.G.... Liotta L.A. (J. Biol. Chem. 1990)
    6. [Study on the association of SNPs of MMP-2 and TIMP-2 genes with the risk of endometriosis and adenomyosis]. (PubMed id 18543216)1, 4, 9 Zhao X.W....Kang S. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    7. Polymorphisms in tissue inhibitors of metalloproteinases-2 and -3 and breast cancer susceptibility and survival. (PubMed id 19431211)1, 4, 9 Peterson N.B....Zheng W. (Int. J. Cancer 2009)
    8. Association of TIMP-4 gene polymorphism with the risk of osteoarthritis in the Korean population. (PubMed id 18301898)1, 4, 9 Lee H.J....Kim S. (Rheumatol. Int. 2008)
    9. Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women. (PubMed id 18177649)1, 4, 9 Kang S....Li Y. (Fertil. Steril. 2008)
    10. The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer. (PubMed id 16275157)1, 4, 9 O-Charoenrat P. and Khantapura P. (Oral Oncol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7077 HGNC: 11821 AceView: TIMP2 Ensembl:ENSG00000035862 euGenes: HUgn7077
    ECgene: TIMP2 H-InvDB: TIMP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIMP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIMP2 gene:
    Search GeneIP for patents involving TIMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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