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TIMP1 Gene

protein-coding   GIFtS: 65

GC0XP047326
TIMP metallopeptidase inhibitor 1
(Previous names: tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: TIMP, CLGI)
Services    

Aliases &
Descriptions
for TIMP1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CLGI 2, 3
EPA 2, 3, 5
EPO 1, 2
FLJ90373 2
HCI 2
OTTHUMP00000023214 2
TIMP 2, 3, 5
TIMP-1 3
Descriptions
Collagenase inhibitor 3
Erythroid-potentiating activity 3
Fibroblast collagenase inhibitor 2, 3
TIMP metallopeptidase inhibitor 1 2
Tissue inhibitor of metalloproteinases 3
erythroid potentiating activity 2
tissue inhibitor of metalloproteinase 1 2
tissue inhibitor of metalloproteinase 1 (erythroid
potentiating activity, collagenase inhibitor) 1
External Ids
HGNC: 118201
Entrez Gene: 70762
UniProtKB: P010333
Ensembl: ENSG000001022657
Search outside databases for aliases for TIMP1 gene

Previous GC identifers: GC0XP046244 GC0XP045702 GC0XP046487 GC0XP046461 GC0XP047197

Summaries
for TIMP1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for TIMP1:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural
inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation
of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs,
the encoded protein is able to promote cell proliferation in a wide range of cell types, and may
also have an anti-apoptotic function. Transcription of this gene is highly inducible in response
to many cytokines and hormones. In addition, the expression from some but not all inactive X
chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is
located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
[provided by RefSeq]

UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates
them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating
the growth and differentiation of only human and murine erythroid progenitors. Known to act on
MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act
on MMP-14

Gene Wiki entry for TIMP1

Genomic Location
for TIMP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TIMP1 gene  

Entrez Gene cytogenetic band: Xp11.3-p11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3-p11.23

TIMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047326:     (about GC identifiers)

Start:
 47,326,634 bp from pter
End:
 47,331,134 bp from pter
Size:
 4,501 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000023.9  NT_079573.3  

Proteins
for TIMP1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033 (See protein sequence)
Recommended Name: Metalloproteinase inhibitor 1 precursor  
Size: 207 amino acids; 23171 Da
Subcellular location: Secreted
PDB structures from and Proteopedia :
1D2B (3D)    1LQN (3D)    1OO9 (3D)    1UEA (3D)    2J0T (3D)    
Secondary accessions: Q14252 Q9UCU1

Post-translational modifications:

  • The activity of TIMP1 is dependent on the presence of disulfide bonds1


    • REFSEQ proteins: NP_003245.1  

    ENSEMBL proteins: 
    ENSP00000366216 ENSP00000366217 ENSP00000218388 ENSP00000366212 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant TIMP1 Protein
    Sigma-Aldrich Proteins for TIMP1  
    R&D Systems Recombinant & Natural Proteins for TIMP1 (TIMP-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TIMP1)
    Human Recombinant Proteins from Abnova (TIMP1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region NAS1653055
    GO:0005578 proteinaceous extracellular matrix IEA--
    About this table

    Antibodies for TIMP1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of TIMP1
    Sigma-Aldrich Antibodies for TIMP1
    R&D Systems Antibodies for TIMP1 (TIMP-1)
    Antibodies from Abcam (TIMP1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TIMP1)
    Novus Biologicals Antibodies for TIMP1

    Assays for TIMP1: 
    Invitrogen Assays for TIMP1
    Millipore Kits and Assays for the Analysis of TIMP1
    R&D Systems ELISAs for TIMP1 (TIMP-1)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for TIMP1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR001134 Netrin_domain
     IPR001820 Prot_inh_TIMP
     IPR015611 TIMP1


       GeneDecks  TIMP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P01033

    ProtoNet protein and cluster: P01033

    1 Blocks protein family: IPB001820 Tissue inhibitor of metalloproteinase

    UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
    Similarity: Belongs to the protease inhibitor I35 (TIMP) family
    Similarity: Contains 1 NTR domain

    Gene Function
    for TIMP1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TIMP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TIMP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003254

                  Applied Biosystems Silencer® siRNAs for TIMP1

                  Sigma-Aldrich siRNA for TIMP1  
                         Sigma-Aldrich shRNA Panels and shRNA for TIMP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TIMP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003254
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003254
                                     untagged cDNA clone in CMV expression vector: NM_003254 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003254

    UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
    Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates
    them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating
    the growth and differentiation of only human and murine erythroid progenitors. Known to act on
    MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act
    on MMP-14

    Genatlas biochemistry entry for TIMP1:
    matrix metalloproteinase,tissue inhibitor 1 (erythroid potentiating activity),involved in the
    regulation of bone modeling and remodeling in normal developing human bone,involved in the
    invasive phenotype of acute myelogenous leukemia,demonstrating polymorphic X-chromosome
    inactivation

    10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Timp1):

    endocrine/exocrine glandgrowth/sizehematopoietic systemhomeostasis/metabolism
    immune systemlife span-post-weaning/agingreproductive systemrespiratory systemtumorigenesis

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857 enzyme inhibitor activity IEA--
    GO:0005515 protein binding IPI2251898
    GO:0008191 metalloendopeptidase inhibitor activity IDA12714508
    About this table

    Pathways & Interactions
    for TIMP1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    5 Millipore Pathways for TIMP1
     Development Leptin signaling via JAK/STAT and MAPK cascades
     Cell adhesion ECM remodeling
     Immune response Oncostatin M signaling via MAPK in human cells
     Immune response IL-10 signaling pathway
     Immune response Oncostatin M signaling via JAK-Stat in human cells

       GeneDecks  TIMP1 for the pathways selected above  
    About GeneDecksing

    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  TIMP1  (Your Favorite Gene powered by Ingenuity) 
     IL-17 Signaling
     Hepatic Fibrosis / Hepatic Stellate Cell Activation
     Leukocyte Extravasation Signaling

       GeneDecks  TIMP1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  TIMP1 


    5/103 Interacting proteins for TIMP1 (P010332 ENSP000002183883) via UniProtKB, MINT, and/or STRING (see all 103 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD63P089622, ENSP000002578573MINT-2981831 MINT-2981920 MINT-2981902 MINT-2981857 MINT-2981881 STRING (score=.937)
    MMP1ENSP000003227883STRING (score=.999)
    MMP3ENSP000002998553STRING (score=.999)
    MMP2ENSP000002190703STRING (score=.995)
    MMP9ENSP000003614053STRING (score=.993)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284 positive regulation of cell proliferation TAS3839290
    GO:0043249 erythrocyte maturation IEA--
    GO:0051045 negative regulation of membrane protein ectodomain proteolysis IDA12714508
    About this table

    Drugs & Compounds
    for TIMP1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TIMP1
    10/45 Novoseek chemical compound relationships for TIMP1 gene (see all 45 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    (4-aminophenyl)mercuric acetate 76.41 4 1379048 (1), 7890773 (1), 11409126 (1)
    matrigel 69.37 21 8740587 (2), 7616276 (1), 17890452 (1), 18159069 (1) (see all 19)
    procollagen 55.65 25 7734146 (4), 15130753 (2), 16820347 (1), 18172937 (1) (see all 16)
    mcp 1 48.37 1 16023726 (1)
    12-o-tetradecanoylphorbol 13-acetate 40.21 31 8913498 (5), 8268245 (2), 8476858 (2), 9665201 (2) (see all 14)
    ribonucleic acid 38.76 5 9589682 (2), 10022430 (1), 15774089 (1), 11408859 (1)
    tgf beta1 36.85 8 11869079 (3), 9826041 (1), 16185342 (1), 16625447 (1) (see all 5)
    methyl selenol 34.91 2 16702316 (2)
    phorbol 33.14 5 7772252 (1), 9054554 (1), 2176183 (1), 12525489 (1)
    hydroxamate 32.96 7 8086430 (2), 12475252 (1), 11415441 (1), 14735194 (1) (see all 5)
    About this table


    Transcripts
    for TIMP1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TIMP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TIMP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003254

                  Sigma-Aldrich siRNA for TIMP1  
                         Sigma-Aldrich shRNA Panels and shRNA for TIMP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003254  

    REFSEQ mRNAs for TIMP1 gene: 

    NM_003254.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003254  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003254
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003254
                                     untagged cDNA clone in CMV expression vector: NM_003254 

    Additional cDNA sequence: 

    AK074854.1 AK296116.1 AK307222.1 AK310206.1 AK311937.1 BC000866.1 BC007097.1 CR407638.1 
    CR541982.1 CR590572.1 CR593351.1 CR602090.1 M12670.1 M59906.1 S68252.1 X02598.1 
    X03124.1 

    23 DOTS entries:

    DT.450920  DT.91861097  DT.91769629  DT.100667068  DT.91769615  DT.97775338  DT.100667069  DT.95237267 
    DT.121285008  DT.87077883  DT.95372856  DT.100850763  DT.121285069  DT.100039515  DT.101985551  DT.100667071 
    DT.100768617  DT.85105205  DT.91829008  DT.92351923  DT.95372857  DT.95372866  DT.95372878 

    24/1070 AceView cDNA sequences (see all 1070 ):

    BP871096 BQ957438 AA477010 BU164412 BM760866 AA365908 AI754597 AA302500 
    CF129285 CF129257 T61289 BU158915 BQ682343 H97196 S68252 BQ694229 
    BQ677637 BM699373 BQ227513 CR602090 BM672931 BU158956 BM994293 BF341062 

    highest scoring ESTs for TIMP1:

    AA001324 AA032054 AA102515 AA135888 AA186788 AA256917 AA291209 AA291737 AA292460 AA292681 

    Unigene Cluster for TIMP1:

    TIMP metallopeptidase inhibitor 1
    Hs.522632  [show with all ESTs]
    Unigene Representative Sequence: BM913048


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000377017  ENST00000377018  ENST00000218388  ENST00000377013  

    Expression
    for TIMP1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TIMP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TIMP1

    1 / 2 / 3

    3 probe-sets matching TIMP1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1693_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D11139 0.20 1.00 0.72 1

    		201666_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003254 0.60 1.00 0.82 1

    		201666_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TIMP1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGAGTGTCT

    SOURCE GeneReport for Unigene cluster: Hs.522632

    Expression variation in blood from EXPOLDB for TIMP1

    Orthologs
    for TIMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TIMP1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 TIMP11   -- TIMP metallopeptidase inhibitor 1 85.83(n)
    79.71(a)    		 403816  NM_001003182.1  NP_001003182.1 
    cow
    (Bos taurus)    		 TIMP11   -- TIMP metallopeptidase inhibitor 1 88.41(n)
    86.96(a)    		 282092  NM_174471.3  NP_776896.1 
    rat
    (Rattus norvegicus)    		 Timp11   -- TIMP metallopeptidase inhibitor 1 78.38(n)
    72.28(a)    		 116510  NM_053819.1  NP_446271.1 
    mouse
    (Mus musculus)    		 Timp11, 5 X (6.20 cM)5
    		 tissue inhibitor of metalloproteinase 11, 5 78.61(n)1
    74.63(a)1    		 218571  NM_001044384.11  NP_001037849.11 
     AL6718855  AY6228535  (see all 22)
    zebrafish
    (Danio rerio)    		 AB120005.12   --   -- 76.52(n)  AB120005.1 
    About this table        Species with no ortholog for TIMP1

    ENSEMBL Gene Tree for TIMP1

    Paralogs
    for TIMP1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TIMP1 gene
    TIMP42  TIMP32  TIMP22  

    SNPs/Variants
    for TIMP1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for TIMP1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 305370

    10/97 Novoseek disease relationships for TIMP1 gene (see all 97 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 71.72 104 11093731 (5), 11819791 (5), 17456311 (5), 12239944 (4) (see all 52)
    metastasis 63.44 227 12717827 (6), 12452001 (5), 11686557 (5), 10570415 (4) (see all 99)
    tumors 61.54 576 12672830 (6), 11335899 (6), 12704667 (5), 8532127 (5) (see all 99)
    osteoarthritis 55.85 22 8091128 (2), 8452582 (2), 10402070 (2), 7876539 (1) (see all 16)
    rheumatoid arthritis 55.35 34 8877931 (2), 7490368 (2), 8452582 (2), 17278779 (2) (see all 28)
    inflammation 54.23 99 7612046 (2), 18758412 (2), 9722227 (2), 17726014 (2) (see all 75)
    gingival overgrowth 51.22 2 18269661 (1), 12479630 (1)
    necrosis 50.95 75 2167246 (2), 9731514 (2), 17904786 (2), 2175694 (2) (see all 71)
    pathological processes 47.73 7 9316744 (1), 17976016 (1), 9349574 (1), 14523226 (1) (see all 6)
    myocardial fibrosis 46.63 5 15638813 (1), 18260972 (1), 15364860 (1), 19254213 (1)
    About this table

    Human Gene Mutation Database: TIMP1
    Genetic Association Database: TIMP1
    Human Genome Epidemiology Navigator: TIMP1 (19 documents)
    Tumor Gene Database: TIMP1

    Medical News
    for TIMP1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for TIMP1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/1670 PubMed articles for TIMP1 gene (see all 1670 ):

    Search for TIMP1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TIMP1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 7076 HGNC: 11820 AceView: TIMP1 Ensembl:ENSG00000102265 euGenes: HUgn7076
    ECgene: TIMP1 H-InvDB: TIMP1

    Other Databases showing TIMP1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing TIMP1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for TIMP1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for TIMP1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for TIMP1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TIMP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TIMP1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TIMP1 Antibodies for TIMP1
     Explore super-pooled esiRNAs Proteins for TIMP1
     Lentivirus-delivered shRNAs for TIMP1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (TIMP1)
     Antibodies (TIMP1)
     Chimera RNAi (TIMP1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (TIMP1)
     Antibodies (TIMP1)
     Search OriGene for TIMP1
     Search Tocris compounds for TIMP1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TIMP1

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    TIMP1 Gene at Home site.
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