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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMP1 Gene

protein-coding   GIFtS: 68
GCID: GC0XP047441

TIMP Metallopeptidase Inhibitor 1

(Previous names: tissue inhibitor of metalloproteinase 1 (erythroid potentiating...)
(Previous symbols: TIMP, CLGI)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TIMP Metallopeptidase Inhibitor 11 2     Tissue Inhibitor Of Metalloproteinases 12 3
TIMP1 2 3 5     TIMP-12 3
CLGI1 2 3     Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity,
Collagenase Inhibitor)1
EPA2 3 5     EPO2
Collagenase Inhibitor2 3     HCI2
Erythroid-Potentiating Activity2 3     Erythroid Potentiating Activity2
Fibroblast Collagenase Inhibitor2 3     Metalloproteinase Inhibitor 12

External Ids:    HGNC: 118201   Entrez Gene: 70762   Ensembl: ENSG000001022657   OMIM: 3053705   UniProtKB: P010333   

Export aliases for TIMP1 gene to outside databases

Previous GC identifers: GC0XP046244 GC0XP045702 GC0XP046487 GC0XP046461 GC0XP047197 GC0XP047326 GC0XP045154


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIMP1 Gene:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the
matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In
addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell
proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this
gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but
not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is
located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. (provided by RefSeq,
Jul 2008)

GeneCards Summary for TIMP1 Gene: 
TIMP1 (TIMP metallopeptidase inhibitor 1) is a protein-coding gene. Diseases associated with TIMP1 include lymphoma, large-cell, immunoblastic, and oral submucous fibrosis, and among its related super-pathways are Inhibition of Matrix Metalloproteinases and Rac1 Pathway. GO annotations related to this gene include metalloendopeptidase inhibitor activity and metal ion binding. An important paralog of this gene is TIMP4.

UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific,
stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1,
MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14

Gene Wiki entry for TIMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMP1 gene promoter:
         Elk-1   Pax-5   Sp1   AP-1   Egr-1   Nkx2-5   Egr-2   PPAR-gamma1   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3-p11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3-p11.23

TIMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047441:  view genomic region     (about GC identifiers)

Start:
47,441,690 bp from pter      End:
47,446,190 bp from pter
Size:
4,501 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033 (See protein sequence)
Recommended Name: Metalloproteinase inhibitor 1 precursor  
Size: 207 amino acids; 23171 Da
Subcellular location: Secreted
6/7 PDB 3D structures from and Proteopedia for TIMP1 (see all 7):
1D2B (3D)        1LQN (3D)        1OO9 (3D)        1UEA (3D)        2J0T (3D)        3MA2 (3D)    
Secondary accessions: Q14252 Q9UCU1

Explore the universe of human proteins at neXtProt for TIMP1: NX_P01033

Explore proteomics data for TIMP1 at MOPED 

Post-translational modifications:

  • UniProtKB: The activity of TIMP1 is dependent on the presence of disulfide bonds
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01033

  • TIMP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMP1 Protein Expression
    REFSEQ proteins: NP_003245.1  
    ENSEMBL proteins: 
     ENSP00000218388   ENSP00000406671   ENSP00000366216   ENSP00000405380   ENSP00000410983  
     ENSP00000366217  
    Reactome Protein details: P01033
    Human Recombinant Protein Products for TIMP1: 
    EMD Millipore Purified and/or Recombinant TIMP1 Protein
    R&D Systems Recombinant & Natural Proteins for TIMP1 (TIMP-1)
    Enzo Life Sciences proteins for TIMP1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TIMP1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TIMP1
    GenScript Custom Purified and Recombinant Proteins Services for TIMP1
    Novus Biologicals TIMP1 Proteins
    Novus Biologicals TIMP1 Lysates
    Sino Biological Recombinant Protein for TIMP1
    Sino Biological Cell Lysate for TIMP1 
    ProSpec Recombinant Protein for TIMP1
    Cloud-Clone Corp. Proteins for TIMP1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IEA--
    GO:0031012extracellular matrix ----
    GO:0031093platelet alpha granule lumen TAS--

    TIMP1 for ontologies           About GeneDecksing



    TIMP1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TIMP1
    R&D Systems Antibodies for TIMP1 (TIMP-1)
    Cell Signaling Technology (CST) Antibodies for TIMP1 
    OriGene Antibodies for TIMP1
    OriGene Custom Antibody Services for TIMP1
    GenScript Custom Superior Antibodies Services for TIMP1
    Novus Biologicals TIMP1 Antibodies
    Abcam antibodies for TIMP1
    Cloud-Clone Corp. Antibodies for TIMP1 
    ThermoFisher Antibody for TIMP1
    LSBio Antibodies in human, mouse, rat for TIMP1 

    Assay Products for TIMP1: 
    EMD Millipore Kits and Assays for the Analysis of TIMP1
    OriGene Custom Assay Services for TIMP1
    R&D Systems ELISAs for TIMP1 (TIMP-1)         (see all)
    GenScript Custom Assay Services for TIMP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIMP1 
    Cloud-Clone Corp. CLIAs for TIMP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR008993 TIMP-like_OB-fold
     IPR027465 TIMP_C_dom
     IPR001134 Netrin_domain
     IPR001820 Prot_inh_TIMP
     IPR015611 TIMP1

    Graphical View of Domain Structure for InterPro Entry P01033

    ProtoNet protein and cluster: P01033

    1 Blocks protein domain: IPB001820 Tissue inhibitor of metalloproteinase

    UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
    Similarity: Belongs to the protease inhibitor I35 (TIMP) family
    Similarity: Contains 1 NTR domain


    TIMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIMP1_HUMAN, P01033
    Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
    their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific,
    stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1,
    MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14

         Genatlas biochemistry entry for TIMP1:
    matrix metalloproteinase,tissue inhibitor 1 (erythroid potentiating activity),involved in the regulation of bone
    modeling and remodeling in normal developing human bone,involved in the invasive phenotype of acute myelogenous
    leukemia,demonstrating polymorphic X-chromosome inactivation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16917503
    GO:0008191metalloendopeptidase inhibitor activity IDA12714508
    GO:0046872metal ion binding IEA--
         
    TIMP1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Timp1):
     cardiovascular system  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  reproductive system  respiratory system  tumorigenesis 

    TIMP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Timp1tm1Pds for TIMP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP1:
    hsa-miR-205* hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMP1
    Sirion Biotech Customized adenovirus for overexpression of TIMP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TIMP1 (see all 7)
    OriGene ORF clones in mouse, rat for TIMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMP1 (NM_003254)
    Sino Biological Human cDNA Clone for TIMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP1
    Sirion Biotech Customized lentivirus for stable overexpression of TIMP1 
                         Customized lentivirus expression plasmids for stable overexpression of TIMP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIMP1
    Search LifeMap BioReagents cell lines for TIMP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIMP1 About   (see all 27)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    Inhibition of Matrix Metalloproteinases0.68
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for TIMP1
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Cell adhesion ECM remodeling
    Immune response Oncostatin M signaling via MAPK in human cells
    Immune response IL-10 signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TIMP1 (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Inhibition of Matrix Metalloproteinases
    Mitochondrial Apoptosis

    2 Cell Signaling Technology (CST) Pathways for TIMP1
        Angiogenesis
    Protein Stability

    5 GeneGo (Thomson Reuters) Pathways for TIMP1
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Cell adhesion ECM remodeling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-10 signaling pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    2 BioSystems Pathways for TIMP1
        Matrix Metalloproteinases
    IL6-mediated signaling events


    5/7        Reactome Pathways for TIMP1 (see all 7)
        Hemostasis
    Extracellular matrix organization
    Platelet degranulation
    Degradation of the extracellular matrix
    Platelet activation, signaling and aggregation


    1         Kegg Pathway  (Kegg details for TIMP1):
        HIF-1 signaling pathway


    TIMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for TIMP1 (P010332, 3 ENSP000002183884) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD63P089622, 3, ENSP000002578574MINT-2981831 MINT-2981920 MINT-2981902 MINT-2981857 MINT-2981881 I2D: score=2 STRING: ENSP00000257857
    ECH1Q130113, ENSP000002214184I2D: score=4 STRING: ENSP00000221418
    MMP1P039563, ENSP000003227884I2D: score=2 STRING: ENSP00000322788
    MMP2P082533, ENSP000002190704I2D: score=1 STRING: ENSP00000219070
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001775cell activation ----
    GO:0002576platelet degranulation TAS--
    GO:0007568aging IEA--
    GO:0007596blood coagulation TAS--
    GO:0008284positive regulation of cell proliferation TAS3839290

    TIMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIMP1 for compounds           About GeneDecksing

    EMD Millipore small molecules for TIMP1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMP1

    10/143 Novoseek inferred chemical compound relationships for TIMP1 gene (see all 143)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (4-aminophenyl)mercuric acetate 76.5 4 1379048 (1), 7890773 (1), 11409126 (1)
    batimastat 75.4 13 10415727 (1), 11448065 (1), 15949468 (1), 9808534 (1) (see all 13)
    matrigel 68.6 22 8740587 (2), 7616276 (1), 17890452 (1), 18159069 (1) (see all 20)
    procollagen 58.8 29 7734146 (4), 15130753 (2), 16820347 (1), 18172937 (1) (see all 20)
    vegf 58.1 162 20193458 (6), 17062432 (5), 16202678 (5), 19787153 (5) (see all 82)
    marimastat 47.3 1 9731514 (1)
    mcp 1 44.5 1 16023726 (1)
    hyaluronic acid 41 60 18172937 (5), 19766963 (5), 18422837 (3), 18175357 (3) (see all 20)
    12-o-tetradecanoylphorbol 13-acetate 38.7 31 8913498 (5), 8268245 (2), 8476858 (2), 9665201 (2) (see all 14)
    doxycycline 37.2 17 17122880 (3), 19442784 (2), 7923879 (2), 17145119 (2) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about TIMP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMP1 gene: 
    NM_003254.2  

    Unigene Cluster for TIMP1:

    TIMP metallopeptidase inhibitor 1
    Hs.522632  [show with all ESTs]
    Unigene Representative Sequence: BM913048
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218388(uc004dif.3) ENST00000456754 ENST00000377017 ENST00000441738
    ENST00000445623 ENST00000377018(uc011mlr.1 uc010nht.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP1:
    hsa-miR-205* hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP1
    Clone
    Products:
         
    OriGene clones in human, mouse for TIMP1 (see all 7)
    OriGene ORF clones in mouse, rat for TIMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMP1 (NM_003254)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP1
    Sirion Biotech Customized lentivirus for stable overexpression of TIMP1 
                         Customized lentivirus expression plasmids for stable overexpression of TIMP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMP1

    Additional mRNA sequence: 

    AK074854.1 AK296116.1 AK307222.1 AK310206.1 AK311937.1 BC000866.1 BC007097.1 CR407638.1 
    CR541982.1 M12670.1 M59906.1 S68252.1 X02598.1 X03124.1 

    23 DOTS entries:

    DT.450920  DT.91861097  DT.91769629  DT.100667068  DT.91769615  DT.97775338  DT.100667069  DT.95237267 
    DT.121285008  DT.87077883  DT.95372856  DT.100850763  DT.121285069  DT.100039515  DT.101985551  DT.100667071 
    DT.100768617  DT.85105205  DT.91829008  DT.92351923  DT.95372857  DT.95372866  DT.95372878 

    24/1070 AceView cDNA sequences (see all 1070):

    AA365908 BP365169 BM991544 CR541982 BU158956 BU540597 CA427755 CA748906 
    CA414054 AA403292 BQ051410 CA306805 BM771834 BM757907 BM670030 BQ224652 
    CA415141 BE857048 AI094329 AI751260 BM994293 CR602090 BU627015 BM756544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMP1 expression in normal human tissues (normalized intensities)      TIMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGTGTCT
    TIMP1 Expression
    About this image


    TIMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
             Cardiac Myocytes   
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Uterus (Reproductive System)
             Uterus Corpus   
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)

    See TIMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMP1

    SOURCE GeneReport for Unigene cluster: Hs.522632
        SABiosciences Expression via Pathway-Focused PCR Arrays including TIMP1 (see all 12): 
              Nephrotoxicity in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TIMP1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timp11 , 5 tissue inhibitor of metalloproteinase 11, 5 78.61(n)1
    74.63(a)1
      X (16.38 cM)5
    218571  NM_001044384.11  NP_001037849.11 
     208701665 
    lizard
    (Anolis carolinensis)
    Reptilia TIMP16
    --
    (see all 3)
    --
    40(a)
    35(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    2(68230888-68238739)
    2(68186411-68195323)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060453.12   -- 76.73(n)    BC060453.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB120005.12   -- 76.52(n)    AB120005.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Timp6
    Tissue inhibitor of metalloproteases
    20(a)
    1 → many
    3R(6029597-6038726)


    ENSEMBL Gene Tree for TIMP1 (if available)
    TreeFam Gene Tree for TIMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMP1 gene
    TIMP42  TIMP32  TIMP22  
    3 SIMAP similar genes for TIMP1 using alignment to 8 protein entries:     TIMP1_HUMAN (see all proteins):
    TIMP4    TIMP2    TIMP3

    TIMP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): TIMP1

    Locus Specific Mutation Databases (LSDB): TIMP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 305370    OMIM disorders: --

    20/248 diseases for TIMP1 (see all 248):    About MalaCards
    lymphoma, large-cell, immunoblastic    oral submucous fibrosis    endodermal sinus tumor    microcystic meningioma
    scleritis    fundus dystrophy    retinitis pigmentosa-2    pulpitis
    conjunctivochalasis    enthesitis-related arthritis    lung giant cell carcinoma    chronic venous leg ulcers
    vulvar intraepithelial neoplasia    status asthmaticus    aneurysm disease    nephrogenic systemic fibrosis
    retinal detachment    keratoconus    poems syndrome    coronary artery aneurysm

    11 diseases from the University of Copenhagen DISEASES database for TIMP1:
    Arthritis     Vascular disease     Periodontal disease     Heart disease
    Liver disease     Carcinoma     Colorectal cancer     Asthma
    Interstitial lung disease     Breast cancer     Chronic obstructive pulmonary disease

    TIMP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for TIMP1 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 72.9 111 11093731 (5), 11819791 (5), 17456311 (5), 12239944 (4) (see all 58)
    metastasis 63.5 241 12717827 (6), 12452001 (5), 11686557 (5), 10570415 (4) (see all 99)
    tumors 61.8 652 12672830 (6), 11335899 (6), 12704667 (5), 16767366 (5) (see all 99)
    inflammation 57.7 101 18758412 (2), 7612046 (2), 9722227 (2), 17726014 (2) (see all 77)
    rheumatoid arthritis 56.3 37 8877931 (2), 19656031 (2), 17278779 (2), 7490368 (2) (see all 30)
    osteoarthritis 55.9 26 8091128 (2), 8452582 (2), 10402070 (2), 7876539 (1) (see all 18)
    necrosis 52 83 2167246 (2), 9731514 (2), 17904786 (2), 2175694 (2) (see all 78)
    gingival overgrowth 49.3 2 18269661 (1), 12479630 (1)
    atherosclerotic plaque 49.2 13 8774133 (3), 16702468 (2), 9918530 (2), 11369004 (1) (see all 9)
    myocardial fibrosis 48.9 5 15638813 (1), 18260972 (1), 15364860 (1), 19254213 (1)

    Genetic Association Database (GAD): TIMP1
    Human Genome Epidemiology (HuGE) Navigator: TIMP1 (36 documents)
    Tumor Gene Database (TGDB): TIMP1

    Export disorders for TIMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMP1 gene, integrated from 9 sources (see all 2160):
    (articles sorted by number of sources associating them with TIMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. (PubMed id 12218659)1, 4, 9 Wollmer M.A....Nitsch R.M. (2002)
    2. A novel tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphism associated with asthma in Australian women. (PubMed id 16061701)1, 4, 9 Lose F....Kedda M.A. (2005)
    3. Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. (PubMed id 1730286)1, 2, 9 Osthues A.... Tschesche H. (1992)
    4. Genes predisposing to rapid aneurysm growth. (PubMed id 17182940)1, 4, 9 Powell J.T. (2006)
    5. Evaluation of MMP3 and TIMP1 as candidate genes for high myopia in young Taiwanese men. (PubMed id 16935611)1, 4, 9 Liang C.L....Juo S.H. (2006)
    6. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)1, 4, 9 Ogata T....Kuivaniemi H. (2005)
    7. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. (PubMed id 9288970)1, 2, 9 Gomis-Rueth F.-X.... Bode W. (1997)
    8. Genetic polymorphism of the tissue inhibitor of metal loproteinase-1 is associated with an increased risk of endometrial cancer. (PubMed id 19758569)1, 4, 9 Yi Y.C....Yang S.F. (2009)
    9. Tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphisms in a Caucasian population with abdominal aortic aneurysm. (PubMed id 17899257)1, 4, 9 Hinterseher I....Bergert H. (2007)
    10. Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings. (PubMed id 12834347)1, 2, 9 Arumugam S. and Van Doren S.R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7076 HGNC: 11820 AceView: TIMP1 Ensembl:ENSG00000102265 euGenes: HUgn7076
    ECgene: TIMP1 Kegg: 7076 H-InvDB: TIMP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMP1 gene:
    Search GeneIP for patents involving TIMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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