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Aliases for TIMP1 Gene

Aliases for TIMP1 Gene

  • TIMP Metallopeptidase Inhibitor 1 2 3 5
  • Tissue Inhibitor Of Metalloproteinases 1 3 4
  • Fibroblast Collagenase Inhibitor 3 4
  • Erythroid-Potentiating Activity 3 4
  • Collagenase Inhibitor 3 4
  • TIMP-1 3 4
  • CLGI 3 4
  • TIMP 3 4
  • EPA 3 4
  • Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor) 2
  • Erythroid Potentiating Activity 3
  • Metalloproteinase Inhibitor 1 3
  • EPO 3
  • HCI 3

External Ids for TIMP1 Gene

Previous HGNC Symbols for TIMP1 Gene

  • TIMP
  • CLGI

Previous GeneCards Identifiers for TIMP1 Gene

  • GC0XP046244
  • GC0XP045702
  • GC0XP046487
  • GC0XP046461
  • GC0XP047197
  • GC0XP047326
  • GC0XP047441
  • GC0XP045154

Summaries for TIMP1 Gene

Entrez Gene Summary for TIMP1 Gene

  • This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIMP1 Gene

TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Chronic Venous Leg Ulcers and Oral Submucous Fibrosis. Among its related pathways are p70S6K Signaling and CREB Pathway. GO annotations related to this gene include cytokine activity and protease binding. An important paralog of this gene is TIMP2.

UniProtKB/Swiss-Prot for TIMP1 Gene

  • Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Gene Wiki entry for TIMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMP1 Gene

Genomics for TIMP1 Gene

Regulatory Elements for TIMP1 Gene

Enhancers for TIMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TIMP1 on UCSC Golden Path with GeneCards custom track

Promoters for TIMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TIMP1 Gene

Chromosome:
X
Start:
47,582,291 bp from pter
End:
47,586,791 bp from pter
Size:
4,501 bases
Orientation:
Plus strand

Genomic View for TIMP1 Gene

Genes around TIMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMP1 Gene

Proteins for TIMP1 Gene

  • Protein details for TIMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01033-TIMP1_HUMAN
    Recommended name:
    Metalloproteinase inhibitor 1
    Protein Accession:
    P01033
    Secondary Accessions:
    • Q14252
    • Q9UCU1

    Protein attributes for TIMP1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23171 Da
    Quaternary structure:
    • Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1.

    Three dimensional structures from OCA and Proteopedia for TIMP1 Gene

neXtProt entry for TIMP1 Gene

Post-translational modifications for TIMP1 Gene

Other Protein References for TIMP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TIMP1 (TIMP1)
  • Abcam antibodies for TIMP1

Protein Products

  • Abcam proteins for TIMP1

Assay Products

  • Enzo Life Sciences assays for TIMP1
  • Abcam assays for TIMP1

No data available for DME Specific Peptides for TIMP1 Gene

Domains & Families for TIMP1 Gene

Gene Families for TIMP1 Gene

Protein Domains for TIMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P01033

UniProtKB/Swiss-Prot:

TIMP1_HUMAN :
  • Contains 1 NTR domain.
  • Belongs to the protease inhibitor I35 (TIMP) family.
Domain:
  • Contains 1 NTR domain.
Family:
  • Belongs to the protease inhibitor I35 (TIMP) family.
genes like me logo Genes that share domains with TIMP1: view

Function for TIMP1 Gene

Molecular function for TIMP1 Gene

GENATLAS Biochemistry:
matrix metalloproteinase,tissue inhibitor 1 (erythroid potentiating activity),involved in the regulation of bone modeling and remodeling in normal developing human bone,involved in the invasive phenotype of acute myelogenous leukemia,demonstrating polymorphic X-chromosome inactivation
UniProtKB/Swiss-Prot Function:
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Gene Ontology (GO) - Molecular Function for TIMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA,IBA --
GO:0005125 cytokine activity IDA 3839290
GO:0005515 protein binding IPI 2251898
GO:0008083 growth factor activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity IDA 3903517
genes like me logo Genes that share ontologies with TIMP1: view
genes like me logo Genes that share phenotypes with TIMP1: view

Animal Models for TIMP1 Gene

MGI Knock Outs for TIMP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TIMP1

CRISPR Products

miRNA for TIMP1 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TIMP1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMP1 Gene

Localization for TIMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMP1 Gene COMPARTMENTS Subcellular localization image for TIMP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
golgi apparatus 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TIMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA,IBA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 3903517
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with TIMP1: view

Pathways & Interactions for TIMP1 Gene

genes like me logo Genes that share pathways with TIMP1: view

Gene Ontology (GO) - Biological Process for TIMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001775 cell activation IEA --
GO:0002576 platelet degranulation TAS --
GO:0007568 aging IEA --
GO:0008284 positive regulation of cell proliferation IDA 3839290
GO:0009725 response to hormone IBA --
genes like me logo Genes that share ontologies with TIMP1: view

No data available for SIGNOR curated interactions for TIMP1 Gene

Drugs & Compounds for TIMP1 Gene

(78) Drugs for TIMP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(65) Additional Compounds for TIMP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIMP1: view

Transcripts for TIMP1 Gene

Unigene Clusters for TIMP1 Gene

TIMP metallopeptidase inhibitor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TIMP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMP1 Gene

No ASD Table

Relevant External Links for TIMP1 Gene

GeneLoc Exon Structure for
TIMP1
ECgene alternative splicing isoforms for
TIMP1

Expression for TIMP1 Gene

mRNA expression in normal human tissues for TIMP1 Gene

mRNA differential expression in normal tissues according to GTEx for TIMP1 Gene

This gene is overexpressed in Artery - Coronary (x5.4) and Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for TIMP1 Gene

This gene is overexpressed in Amniocyte (19.1), Vitreous humor (12.2), Islet of Langerhans (6.3), and Milk (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMP1 Gene



Protein tissue co-expression partners for TIMP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIMP1 Gene:

TIMP1

SOURCE GeneReport for Unigene cluster for TIMP1 Gene:

Hs.522632

mRNA Expression by UniProt/SwissProt for TIMP1 Gene:

P01033-TIMP1_HUMAN
Tissue specificity: Detected in rheumatoid synovial fluid (at protein level).
genes like me logo Genes that share expression patterns with TIMP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TIMP1 Gene

Orthologs for TIMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIMP1 34
  • 88.41 (n)
  • 86.96 (a)
TIMP1 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMP1 34
  • 85.83 (n)
  • 79.71 (a)
TIMP1 35
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timp1 34
  • 78.44 (n)
  • 74.63 (a)
Timp1 16
Timp1 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timp1 34
  • 78.38 (n)
  • 72.28 (a)
oppossum
(Monodelphis domestica)
Mammalia TIMP1 35
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMP1 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7905 34
Species where no ortholog for TIMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIMP1 Gene

ENSEMBL:
Gene Tree for TIMP1 (if available)
TreeFam:
Gene Tree for TIMP1 (if available)

Paralogs for TIMP1 Gene

Paralogs for TIMP1 Gene

(3) SIMAP similar genes for TIMP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TIMP1: view

Variants for TIMP1 Gene

Variation tolerance for TIMP1 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.29; 76.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMP1 Gene

Human Gene Mutation Database (HGMD)
TIMP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TIMP1 Gene

Disorders for TIMP1 Gene

MalaCards: The human disease database

(61) MalaCards diseases for TIMP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic venous leg ulcers
oral submucous fibrosis
  • oral cavity submucous fibrosis
gingival overgrowth
  • gingival enlargement
pleural tuberculosis
  • pearly disease
nephrogenic systemic fibrosis
  • nsf
- elite association - COSMIC cancer census association via MalaCards
Search TIMP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIMP1

Genetic Association Database (GAD)
TIMP1
Human Genome Epidemiology (HuGE) Navigator
TIMP1
Tumor Gene Database (TGDB):
TIMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMP1
genes like me logo Genes that share disorders with TIMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIMP1 Gene

Publications for TIMP1 Gene

  1. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. (PMID: 16917503) Jung K.K. … Kim H.R. (EMBO J. 2006) 3 4 22 65
  2. Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. (PMID: 12218659) Wollmer M.A. … Nitsch R.M. (Psychiatr. Genet. 2002) 3 22 46 65
  3. NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases. (PMID: 10623524) Wu B. … Van Doren S.R. (J. Mol. Biol. 2000) 3 4 22 65
  4. TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling. (PMID: 24635319) Lee S.Y. … Lee M.A. (Biochem. J. 2014) 3 4 65
  5. Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. (PMID: 23522389) Toricelli M. … Jasiulionis M.G. (Mol. Cancer 2013) 3 4 65

Products for TIMP1 Gene

  • Addgene plasmids for TIMP1

Sources for TIMP1 Gene

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