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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMP1 Gene

protein-coding   GIFtS: 68
GCID: GC0XP047441

TIMP metallopeptidase inhibitor 1

(Previous names: tissue inhibitor of metalloproteinase 1 (erythroid potentiating...)
(Previous symbols: TIMP, CLGI)
 Explore 276 diseases affiliated with
TIMP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TIMP1    

Aliases
for TIMP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TIMP Metallopeptidase Inhibitor 11 2     Fibroblast Collagenase Inhibitor2 3
TIMP1 2 3 5     Tissue Inhibitor Of Metalloproteinases 12 3
CLGI1 2 3     TIMP-12 3
EPA2 3 5     Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity,
Collagenase Inhibitor)1
EPO1 2     HCI2
Collagenase Inhibitor2 3     Erythroid Potentiating Activity2
Erythroid-Potentiating Activity2 3     Metalloproteinase Inhibitor 12

External Ids:    HGNC: 118201   Entrez Gene: 70762   Ensembl: ENSG000001022657   OMIM: 3053705   UniProtKB: P010333   

Export aliases for TIMP1 gene to outside databases

Previous GC identifers: GC0XP046244 GC0XP045702 GC0XP046487 GC0XP046461 GC0XP047197 GC0XP047326 GC0XP045154


Summaries
for TIMP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TIMP1:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the
matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In
addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell
proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene
is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all
inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located
within intron 6 of the synapsin I gene and is transcribed in the opposite direction. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific,
stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1,
MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14

Gene Wiki entry for TIMP1


Genomic Views
for TIMP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMP1 gene promoter:
         Elk-1   Pax-5   Sp1   AP-1   Egr-1   Nkx2-5   Egr-2   PPAR-gamma1   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3-p11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3-p11.23

TIMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047441:  view genomic region     (about GC identifiers)

Start:
 47,441,690 bp from pter      End:
 47,446,190 bp from pter
Size:
 4,501 bases      Orientation:
 plus strand

Proteins
for TIMP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033 (See protein sequence)
Recommended Name: Metalloproteinase inhibitor 1 precursor  
Size: 207 amino acids; 23171 Da
Subcellular location: Secreted
6/7 PDB 3D structures from and Proteopedia for TIMP1 (see all 7):
1D2B (3D)        1LQN (3D)        1OO9 (3D)        1UEA (3D)        2J0T (3D)        3MA2 (3D)    
Secondary accessions: Q14252 Q9UCU1

Explore the universe of human proteins at neXtProt for TIMP1: NX_P01033

Post-translational modifications:

  • The activity of TIMP1 is dependent on the presence of disulfide bonds1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01033

    • TIMP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003245.1  
    ENSEMBL proteins: 
     ENSP00000218388   ENSP00000406671   ENSP00000366216   ENSP00000405380   ENSP00000410983  
     ENSP00000366217  
    Reactome Protein details: P01033
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant TIMP1 Protein
    R&D Systems Recombinant & Natural Proteins for TIMP1 (TIMP-1)
    Enzo Life Sciences proteins for TIMP1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TIMP1
    OriGene Custom Protein Services for TIMP1 
    GenScript Custom Purified and Recombinant Proteins Services for TIMP1
    Novus Biologicals TIMP1 Proteins
    Novus Biologicals TIMP1 Lysates
    Sino Biological Recombinant Protein for TIMP1
    ProSpec Recombinant Protein for TIMP1
    Uscn Proteins for TIMP1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IEA--
    GO:0031012extracellular matrix ----
    GO:0031093platelet alpha granule lumen TAS--


    TIMP1 for ontologies           About GeneDecksing



    TIMP1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TIMP1
    R&D Systems Antibodies for TIMP1 (TIMP-1)
    Cell Signaling Technology (CST) Antibodies for TIMP1 
    OriGene Antibodies (see all 3): TIMP1
    OriGene Custom Antibody Services for TIMP1 
    GenScript Custom Superior Antibodies Services for TIMP1
    Novus Biologicals TIMP1 Antibodies
    Abcam antibodies for TIMP1 
    Uscn Antibodies for TIMP1
    ThermoFisher Antibody for TIMP1

    Assay Products for TIMP1: 
    EMD Millipore Kits and Assays for the Analysis of TIMP1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for TIMP1 (TIMP-1)         (see all)
    GenScript Custom Assay Services for TIMP1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TIMP1

    Protein Domains /
    Families
    for TIMP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TIMP1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008993 TIMP-like_OB-fold
     IPR001134 Netrin_domain
     IPR001820 Prot_inh_TIMP
     IPR015611 TIMP1

    Graphical View of Domain Structure for InterPro Entry P01033

    ProtoNet protein and cluster: P01033

    1 Blocks protein family: IPB001820 Tissue inhibitor of metalloproteinase

    UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
    Similarity: Belongs to the protease inhibitor I35 (TIMP) family
    Similarity: Contains 1 NTR domain


    Function
    for TIMP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TIMP1_HUMAN, P01033
    Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to
    their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific,
    stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1,
    MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14

         Genatlas biochemistry entry for TIMP1:
    matrix metalloproteinase,tissue inhibitor 1 (erythroid potentiating activity),involved in the regulation of bone
    modeling and remodeling in normal developing human bone,involved in the invasive phenotype of acute myelogenous
    leukemia,demonstrating polymorphic X-chromosome inactivation

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TIMP1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP1:
    hsa-miR-205* hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMP1 (see all 7)
    OriGene shRNA RFP: TIMP1
    OriGene siRNA: TIMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TIMP1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMP1 (NM_003254)
    Sino Biological Human cDNA Clone for TIMP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TIMP1
    Search LifeMap BioReagents cell lines for TIMP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMP1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI2251898
    GO:0008191metalloendopeptidase inhibitor activity IDA12714508
    GO:0046872metal ion binding IEA--


    TIMP1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Timp1tm1Pds for TIMP1
         10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Timp1):
     cardiovascular system  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  reproductive system  respiratory system  tumorigenesis 

    TIMP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TIMP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for TIMP1
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Cell adhesion ECM remodeling
    Immune response Oncostatin M signaling via MAPK in human cells
    Immune response IL-10 signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TIMP1 (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Inhibition of Matrix Metalloproteinases
    Mitochondrial Apoptosis

    2 Cell Signaling Technology (CST) Pathways for TIMP1
        Angiogenesis
    Protein Stability

    5 GeneGo (Thomson Reuters) Pathways for TIMP1
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Cell adhesion ECM remodeling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-10 signaling pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    2 BioSystems Pathways for TIMP1 
        Matrix Metalloproteinases
    IL6-mediated signaling events

    5/7        Reactome Pathways for TIMP1 (see all 7)
        Hemostasis
    Extracellular matrix organization
    Platelet degranulation
    Degradation of the extracellular matrix
    Platelet activation, signaling and aggregation



    TIMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for TIMP1 (P010332, 3 ENSP000002183884) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD63P089622, 3, ENSP000002578574MINT-2981831 MINT-2981920 MINT-2981902 MINT-2981857 MINT-2981881 I2D: score=2 STRING: ENSP00000257857
    ECH1Q130113, ENSP000002214184I2D: score=4 STRING: ENSP00000221418
    MMP1P039563, ENSP000003227884I2D: score=2 STRING: ENSP00000322788
    MMP2P082533, ENSP000002190704I2D: score=1 STRING: ENSP00000219070
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001775cell activation ----
    GO:0002576platelet degranulation TAS--
    GO:0007568aging IEA--
    GO:0007596blood coagulation TAS--
    GO:0008284positive regulation of cell proliferation TAS3839290


    TIMP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TIMP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIMP1 for compounds           About GeneDecksing

    EMD Millipore small molecules for TIMP1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMP1
    10/143 Novoseek chemical compound relationships for TIMP1 gene (see all 143)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (4-aminophenyl)mercuric acetate 76.5 4 1379048 (1), 7890773 (1), 11409126 (1)
    batimastat 75.4 13 10415727 (1), 11448065 (1), 15949468 (1), 9808534 (1) (see all 13)
    matrigel 68.6 22 8740587 (2), 7616276 (1), 17890452 (1), 18159069 (1) (see all 20)
    procollagen 58.8 29 7734146 (4), 15130753 (2), 16820347 (1), 18172937 (1) (see all 20)
    vegf 58.1 162 20193458 (6), 17062432 (5), 16202678 (5), 19787153 (5) (see all 82)
    marimastat 47.3 1 9731514 (1)
    mcp 1 44.5 1 16023726 (1)
    hyaluronic acid 41 60 18172937 (5), 19766963 (5), 18422837 (3), 18175357 (3) (see all 20)
    12-o-tetradecanoylphorbol 13-acetate 38.7 31 8913498 (5), 8268245 (2), 8476858 (2), 9665201 (2) (see all 14)
    doxycycline 37.2 17 17122880 (3), 19442784 (2), 7923879 (2), 17145119 (2) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about TIMP1 

    Transcripts
    for TIMP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TIMP1 gene: 
    NM_003254.2  

    Unigene Cluster for TIMP1:

    TIMP metallopeptidase inhibitor 1
    Hs.522632  [show with all ESTs]
    Unigene Representative Sequence: BM913048
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218388(uc004dif.3) ENST00000456754 ENST00000377017 ENST00000441738
    ENST00000445623 ENST00000377018(uc011mlr.1 uc010nht.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TIMP1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMP1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMP1:
    hsa-miR-205* hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMP1 (see all 7)
    OriGene shRNA RFP: TIMP1
    OriGene siRNA: TIMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMP1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMP1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMP1 (NM_003254)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMP1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMP1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMP1

    Additional cDNA sequence: 

    AK074854.1 AK296116.1 AK307222.1 AK310206.1 AK311937.1 BC000866.1 BC007097.1 CR407638.1 
    CR541982.1 M12670.1 M59906.1 S68252.1 X02598.1 X03124.1 

    23 DOTS entries:

    DT.450920  DT.91861097  DT.91769629  DT.100667068  DT.91769615  DT.97775338  DT.100667069  DT.95237267 
    DT.121285008  DT.87077883  DT.95372856  DT.100850763  DT.121285069  DT.100039515  DT.101985551  DT.100667071 
    DT.100768617  DT.85105205  DT.91829008  DT.92351923  DT.95372857  DT.95372866  DT.95372878 

    24/1070 AceView cDNA sequences (see all 1070):

    AA327472 N48207 AI754597 BP365185 BU158956 CA415141 BM547390 BM672931 
    AI753949 BM770983 AA401443 BM770732 BM994293 CR593351 W80844 AA428326 
    CF129285 BX957087 BE787306 BQ954269 S68252 AA477010 BM670030 BQ224652 

    GeneLoc Exon Structure


    Expression
    for TIMP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAGTGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TIMP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumVeinsVascular Smooth Muscle CellsSmooth Muscle
    HeartAortic Arch ArteriesVascular Smooth Muscle CellsMyocardium, Neural Crest, Smooth Muscle
    HeartEndocardiumVascular Smooth Muscle CellsSmooth Muscle
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TIMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMP1

    SOURCE GeneReport for Unigene cluster: Hs.522632
        SABiosciences Expression via Pathway-Focused PCR Arrays including TIMP1 (see all 12): 
              Nephrotoxicity in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat

    Primer
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    Orthologs
    for TIMP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TIMP1 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia TIMP16
    		 --
    		 43(a)
    		 1 ↔ 1
    		 2(68232439-68237829)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC060453.12   -- 76.73(n)    BC060453.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AB120005.12   -- 76.52(n)    AB120005.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Timp6
    		 Tissue inhibitor of metalloproteases
    		 18(a)
    		 1 → many
    		 3R(6029597-6038726)


    ENSEMBL Gene Tree for TIMP1 (if available)
    TreeFam Gene Tree for TIMP1 (if available) 

    Paralogs
    for TIMP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMP1 gene
    TIMP42  TIMP32  TIMP22  
    3 SIMAP similar genes for TIMP1 using alignment to 8 protein entries:     TIMP1_HUMAN (see all proteins):
    TIMP4    TIMP2    TIMP3

    TIMP1 for paralogs           About GeneDecksing



    Genomic Variants
    for TIMP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): TIMP1

    Locus Specific Mutation Databases (LSDB): TIMP1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMP1
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    Disorders / Diseases
    for TIMP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TIMP1 for disorders           About GeneDecksing

    OMIM gene information: 305370    OMIM disorders: --

    20/276 diseases for TIMP1 (see all 276):    About MalaCards
    lymphoma, large-cell, immunoblastic    open-angle glaucoma    pure red-cell aplasia    relapsing-remitting multiple sclerosis
    sorsby fundus dystrophy    oral submucous fibrosis    diffuse large b-cell lymphoma    subacute sclerosing panencephalitis
    primary open angle glaucoma    spinal stenosis    proliferative diabetic retinopathy    chronic venous leg ulcers
    hemolytic-uremic syndrome    polycythemia vera    refractive error    non-small cell lung carcinoma
    endodermal sinus tumor    retinitis pigmentosa-2    status asthmaticus    aortic aneurysm

    11 diseases from the University of Copenhagen DISEASES database for TIMP1:
    Arthritis     Vascular disease     Periodontal disease     Heart disease
    Liver disease     Carcinoma     Colorectal cancer     Asthma
    Breast cancer     Interstitial lung disease     Chronic obstructive pulmonary disease

    10/98 Novoseek disease relationships for TIMP1 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 72.9 111 11093731 (5), 11819791 (5), 17456311 (5), 12239944 (4) (see all 58)
    metastasis 63.5 241 12717827 (6), 12452001 (5), 11686557 (5), 10570415 (4) (see all 99)
    tumors 61.8 652 12672830 (6), 11335899 (6), 12704667 (5), 16767366 (5) (see all 99)
    inflammation 57.7 101 18758412 (2), 7612046 (2), 9722227 (2), 17726014 (2) (see all 77)
    rheumatoid arthritis 56.3 37 8877931 (2), 19656031 (2), 17278779 (2), 7490368 (2) (see all 30)
    osteoarthritis 55.9 26 8091128 (2), 8452582 (2), 10402070 (2), 7876539 (1) (see all 18)
    necrosis 52 83 2167246 (2), 9731514 (2), 17904786 (2), 2175694 (2) (see all 78)
    gingival overgrowth 49.3 2 18269661 (1), 12479630 (1)
    atherosclerotic plaque 49.2 13 8774133 (3), 16702468 (2), 9918530 (2), 11369004 (1) (see all 9)
    myocardial fibrosis 48.9 5 15638813 (1), 18260972 (1), 15364860 (1), 19254213 (1)

    Genetic Association Database (GAD): TIMP1
    Human Genome Epidemiology (HuGE) Navigator: TIMP1 (36 documents)
    Tumor Gene Database (TGDB): TIMP1

    Export disorders for TIMP1 gene to outside databases

    Publications
    for TIMP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMP1 gene, integrated from 9 sources (see all 2132):
    (articles sorted by number of sources associating them with TIMP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. (PubMed id 12218659)1, 4, 9 Wollmer M.A....Nitsch R.M. (2002)
    2. A novel tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphism associated with asthma in Australian women. (PubMed id 16061701)1, 4, 9 Lose F....Kedda M.A. (2005)
    3. Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. (PubMed id 1730286)1, 2, 9 Osthues A.... Tschesche H. (1992)
    4. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. (PubMed id 15944607)1, 4, 9 Ogata T....Kuivaniemi H. (2005)
    5. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. (PubMed id 9288970)1, 2, 9 Gomis-Rueth F.-X.... Bode W. (1997)
    6. Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings. (PubMed id 12834347)1, 2, 9 Arumugam S. and Van Doren S.R. (2003)
    7. NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases. (PubMed id 10623524)1, 2, 9 Wu B.... Van Doren S.R. (2000)
    8. Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1. (PubMed id 17050530)1, 2 Iyer S.... Acharya K.R. (2007)
    9. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (2006)
    10. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)

    External Searches for TIMP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TIMP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7076 HGNC: 11820 AceView: TIMP1 Ensembl:ENSG00000102265 euGenes: HUgn7076
    ECgene: TIMP1 H-InvDB: TIMP1

    Other Databases showing TIMP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TIMP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TIMP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TIMP1 gene:
    Search GeneIP for patents involving TIMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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