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TIMMDC1 Gene

protein-coding   GIFtS: 45
GCID: GC03P119218

Translocase Of Inner Mitochondrial Membrane Domain Containing...

(Previous name: chromosome 3 open reading frame 1)
(Previous symbol: C3orf1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Inner Mitochondrial Membrane Domain Containing 11 2     Complex I Assembly Factor TIMMDC1, Mitochondrial2
C3orf11 2 3 5     M5-14 Protein2
Translocase Of Inner Mitochondrial Membrane Domain-Containing Protein 12 3     Transmembrane Protein C3orf12
Chromosome 3 Open Reading Frame 11     Protein M5-143

External Ids:    HGNC: 13211   Entrez Gene: 513002   Ensembl: ENSG000001138457   OMIM: 6155345   UniProtKB: Q9NPL83   

Export aliases for TIMMDC1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TIMMDC1 Gene:
TIMMDC1 (translocase of inner mitochondrial membrane domain containing 1) is a protein-coding gene. Diseases associated with TIMMDC1 include primary biliary cirrhosis, and intrahepatic cholangiocarcinoma.

UniProtKB/Swiss-Prot: TIDC1_HUMAN, Q9NPL8
Function: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex
(complex I). Participates in constructing the membrane arm of complex I

Gene Wiki entry for TIMMDC1 (C3orf1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TIMMDC1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMMDC1 promoter sequence
   Search Chromatin IP Primers for TIMMDC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMMDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.33

TIMMDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMMDC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P119218:  view genomic region     (about GC identifiers)

Start:
119,217,368 bp from pter      End:
119,243,937 bp from pter
Size:
26,570 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TIDC1_HUMAN, Q9NPL8 (See protein sequence)
Recommended Name: Complex I assembly factor TIMMDC1, mitochondrial  
Size: 285 amino acids; 32178 Da
Subunit: Associates with the intermediate 315 kDa subcomplex of incompletely assembled complex I
Secondary accessions: D3DN81 Q6IAJ7 Q6UWU6 Q9NPR3 Q9NPS5 Q9P0Y6

Explore the universe of human proteins at neXtProt for TIMMDC1: NX_Q9NPL8

Explore proteomics data for TIMMDC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIMMDC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057673.2  
    ENSEMBL proteins: 
     ENSP00000418803   ENSP00000419510   ENSP00000264244   ENSP00000417083   ENSP00000418846  
     ENSP00000420122   ENSP00000417205   ENSP00000420812  

    TIMMDC1 Human Recombinant Protein Products:

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    Novus Biologicals TIMMDC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TIMMDC1 Antibody Products:

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    Abcam antibodies for TIMMDC1
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    ThermoFisher Antibodies for TIMMDC1
    Search LSBio for Antibodies for TIMMDC1

    TIMMDC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003397 Tim17/Tim22/Tim23/PMP24

    Graphical View of Domain Structure for InterPro Entry Q9NPL8

    ProtoNet protein and cluster: Q9NPL8

    1 Blocks protein domain: IPB003397 Mitochondrial import inner membrane translocase

    UniProtKB/Swiss-Prot: TIDC1_HUMAN, Q9NPL8
    Similarity: Belongs to the Tim17/Tim22/Tim23 family


    TIMMDC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIDC1_HUMAN, Q9NPL8
    Function: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex
    (complex I). Participates in constructing the membrane arm of complex I

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Timmdc1):

     hematopoietic system  immune system  mortality/aging 

    TIMMDC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIMMDC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIMMDC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMMDC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMMDC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIMMDC1:
    hsa-mir-17-3p (MIRT050760)

    Block miRNA regulation of human, mouse, rat TIMMDC1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TIMMDC1:
    hsa-miR-3924
    SwitchGear 3'UTR luciferase reporter plasmidTIMMDC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIMMDC1
    Predesigned siRNA for gene silencing in human, mouse, rat TIMMDC1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TIMMDC1

    Clone
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    OriGene clones in human, mouse for TIMMDC1 (see all 7)
    OriGene ORF clones in mouse, rat for TIMMDC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TIMMDC1
    Sino Biological Human cDNA Clone for TIMMDC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMMDC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMMDC1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TIMMDC1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMMDC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIDC1_HUMAN, Q9NPL8: Mitochondrion membrane; Multi-pass membrane protein

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane IEA--

    TIMMDC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIMMDC1
    Interactions:

        Search GeneGlobe Interaction Network for TIMMDC1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TIMMDC1 (Q9NPL83 ENSP000004188034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIMMDC1 (TIDC1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TIMMDC1 gene: 
    NM_016589.3  

    Unigene Cluster for TIMMDC1:

    Translocase of inner mitochondrial membrane domain containing 1
    Hs.477287  [show with all ESTs]
    Unigene Representative Sequence: NM_016589
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494664(uc003ecn.3 uc003eco.3 uc003ecp.3) ENST00000493694
    ENST00000264244 ENST00000486418 ENST00000492164 ENST00000466984 ENST00000463927
    ENST00000498399 ENST00000469324
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TIMMDC1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TIMMDC1:
    hsa-miR-3924
    SwitchGear 3'UTR luciferase reporter plasmidTIMMDC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TIMMDC1
    Predesigned siRNA for gene silencing in human, mouse, rat TIMMDC1
    Clone
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    OriGene clones in human, mouse for TIMMDC1 (see all 7)
    OriGene ORF clones in mouse, rat for TIMMDC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TIMMDC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMMDC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMMDC1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIMMDC1
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMMDC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMMDC1
      QuantiTect SYBR Green Assays in human, mouse, rat TIMMDC1
      QuantiFast Probe-based Assays in human, mouse, rat TIMMDC1

    Additional mRNA sequence: 

    AF139077.1 AF210057.1 AK026250.1 AK225954.1 AL136622.1 AL390077.1 AL390090.1 AL390094.1 
    AY358633.1 BC012341.1 CR457158.1 CR533524.1 

    13 DOTS entries:

    DT.455212  DT.101984379  DT.100660806  DT.100721374  DT.102826710  DT.95186853  DT.100030187  DT.100030189 
    DT.95186851  DT.95186801  DT.95308221  DT.100690426  DT.40116899 

    Selected AceView cDNA sequences (see all 436):

    AI372954 AI537728 BU738528 CA423380 F01657 CR611920 CR609519 BQ001322 
    AW190546 BM721330 CA416536 AI475865 CB105366 BE221926 BM848298 AA579831 
    CD742829 BF062474 BF109523 CB851519 BU627859 CD366743 AI745072 BM975362 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TIMMDC1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                                            -     -                                                         
    SP2:                                                  -                                                         
    SP3:                                            -     -                       -     -                           
    SP4:                                            -     -     -                                                   
    SP5:                                            -     -     -     -                                             


    ECgene alternative splicing isoforms for TIMMDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIMMDC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATATCCA
    TIMMDC1 Expression
    About this image

    TIMMDC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIMMDC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477287

    UniProtKB/Swiss-Prot: TIDC1_HUMAN, Q9NPL8
    Tissue specificity: Generalized expression enhanced in heart and skeletal muscle

        Custom PCR Arrays for TIMMDC1
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    QuantiFast Probe-based Assays in human, mouse, rat TIMMDC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMMDC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TIMMDC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timmdc11 , 5 RIKEN cDNA 4930455C21 gene5
    translocase of inner mitochondrial membrane domain more1
    78.17(n)1
    71.48(a)1
      16 (26.86 cM)5
    769161  NM_024273.21  NP_077235.21 
     384983475 
    chicken
    (Gallus gallus)
    Aves TIMMDC11 translocase of inner mitochondrial membrane domain more 60.47(n)
    52.56(a)
      418453  NM_001257290.1  NP_001244219.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIMMDC16
    translocase of inner mitochondrial membrane domain...
    52(a)
    1 ↔ 1
    3(162394812-162406054)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20452 Xenopus laevis transcribed sequence with weak similarity more 69.18(n)    48025782 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.183692 Transcribed sequence with weak similarity to protein more 69.41(n)    CK353638.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 140up1 upstream of RpII140 45.61(n)
    31.36(a)
      41720  NM_001275632.1  NP_001262561.1 


    ENSEMBL Gene Tree for TIMMDC1 (if available)
    TreeFam Gene Tree for TIMMDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIMMDC1 (see all 601)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs716197481,2
    C--116617370(+) GTGTG-/TGTG  
     
    /TGTGTG
    AGATA
    1 -- int11NA 2
    rs1823299271,2
    --119215698(+) ACAGTA/GCGAGC 1 -- us2k10--------
    rs1147137201,2
    C,F--119215773(+) CTTCCG/ATTACC 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1152565941,2
    C--119215778(+) GTTACA/CCAAAT 1 -- us2k10--------
    rs1915085511,2
    --119216012(+) CAGCCA/GTTTTC 1 -- us2k10--------
    rs1449489401,2
    C--119216057(+) CCCACC/TTCTAC 1 -- us2k10--------
    rs1831154151,2
    --119216145(+) ACTGCA/GGTTCT 1 -- us2k10--------
    rs1479444051,2
    --119216244(+) TGTTGC/TAAGTG 1 -- us2k10--------
    rs1881903941,2
    --119216511(+) TACACA/GAATAT 1 -- us2k10--------
    rs20495001,2
    C,F,O,A,H--119216554(-) AAGTAC/TAGTTT 1 -- us2k128Minor allele frequency- N:0.00MN NS EA NA WA CSA 4409

    HapMap Linkage Disequilibrium report for TIMMDC1 (119217368 - 119243937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TIMMDC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829695CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMMDC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMMDC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615534    OMIM disorders: --

    8 diseases for TIMMDC1:    About MalaCards
    primary biliary cirrhosis    intrahepatic cholangiocarcinoma    cholangiocarcinoma    chronic lymphocytic leukemia
    multiple sclerosis    arthritis    leukemia    malaria


    TIMMDC1 for disorders           About GeneDecksing


    Export disorders for TIMMDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIMMDC1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TIMMDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and expression analysis of C3orf1, a novel human gene homologous to the Drosophila RP140-upstream gene. (PubMed id 11092749)1, 2, 3 Escarceller M.... Estivill X. (DNA Seq. 2000)
    2. Assembly factors for the membrane arm of human complex I. (PubMed id 24191001)1, 2 Andrews B.... Walker J.E. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)1 Thompson S.D....Glass D.N. (Arthritis Rheum. 2012)
    8. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. (PubMed id 23000144)1 Nakamura M....Ishibashi H. (Am. J. Hum. Genet. 2012)
    9. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51300 HGNC: 1321 AceView: C3orf1 Ensembl:ENSG00000113845 euGenes: HUgn51300
    ECgene: TIMMDC1 H-InvDB: TIMMDC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIMMDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIMMDC1 gene:
    Search GeneIP for patents involving TIMMDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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