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Aliases for TIMM9 Gene

Aliases for TIMM9 Gene

  • Translocase Of Inner Mitochondrial Membrane 9 Homolog (Yeast) 2 3
  • TIM9A 3 4
  • TIM9 3 4
  • Translocase Of Inner Mitochondrial Membrane 9 (Yeast) Homolog 2
  • TIMM9A 4

External Ids for TIMM9 Gene

Previous GeneCards Identifiers for TIMM9 Gene

  • GC14M056199
  • GC14M052671
  • GC14M056865
  • GC14M057946
  • GC14M058875
  • GC14M039039

Summaries for TIMM9 Gene

Entrez Gene Summary for TIMM9 Gene

  • TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

GeneCards Summary for TIMM9 Gene

TIMM9 (Translocase Of Inner Mitochondrial Membrane 9 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. GO annotations related to this gene include protein homodimerization activity and chaperone binding.

UniProtKB/Swiss-Prot for TIMM9 Gene

  • Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Gene Wiki entry for TIMM9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM9 Gene

Genomics for TIMM9 Gene

Regulatory Elements for TIMM9 Gene

Genomic Location for TIMM9 Gene

Chromosome:
14
Start:
58,408,494 bp from pter
End:
58,427,614 bp from pter
Size:
19,121 bases
Orientation:
Minus strand

Genomic View for TIMM9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM9 Gene

Proteins for TIMM9 Gene

  • Protein details for TIMM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5J7-TIM9_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim9
    Protein Accession:
    Q9Y5J7
    Secondary Accessions:
    • B2R584

    Protein attributes for TIMM9 Gene

    Size:
    89 amino acids
    Molecular mass:
    10378 Da
    Quaternary structure:
    • Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

    Three dimensional structures from OCA and Proteopedia for TIMM9 Gene

neXtProt entry for TIMM9 Gene

Proteomics data for TIMM9 Gene at MOPED

Post-translational modifications for TIMM9 Gene

  • Ubiquitination at Lys 81
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TIMM9 Gene

Domains & Families for TIMM9 Gene

Protein Domains for TIMM9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TIMM9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5J7

UniProtKB/Swiss-Prot:

TIM9_HUMAN :
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
  • Belongs to the small Tim family.
Domain:
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
Family:
  • Belongs to the small Tim family.
genes like me logo Genes that share domains with TIMM9: view

No data available for Gene Families for TIMM9 Gene

Function for TIMM9 Gene

Molecular function for TIMM9 Gene

GENATLAS Biochemistry:
translocase of inner mitochondrial membrane 9 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S cerevisiae Tim9p ortholog,complexing with Tim10p and essential for escorting a class of multimembrane-spanning proteins
UniProtKB/Swiss-Prot Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Gene Ontology (GO) - Molecular Function for TIMM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IDA 16387659
GO:0005515 protein binding IPI 14726512
GO:0008270 zinc ion binding TAS 10552927
GO:0008565 protein transporter activity IBA --
GO:0042803 protein homodimerization activity IPI 16387659
genes like me logo Genes that share ontologies with TIMM9: view
genes like me logo Genes that share phenotypes with TIMM9: view

Animal Model Products

miRNA for TIMM9 Gene

miRTarBase miRNAs that target TIMM9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM9 Gene

Localization for TIMM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM9 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM9 Gene COMPARTMENTS Subcellular localization image for TIMM9 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for TIMM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005758 mitochondrial intermembrane space TAS 14726512
GO:0042719 mitochondrial intermembrane space protein transporter complex TAS 10552927
GO:0042721 mitochondrial inner membrane protein insertion complex IBA --
genes like me logo Genes that share ontologies with TIMM9: view

Pathways & Interactions for TIMM9 Gene

genes like me logo Genes that share pathways with TIMM9: view

Pathways by source for TIMM9 Gene

2 Reactome pathways for TIMM9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TIMM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0007605 sensory perception of sound TAS 10552927
GO:0015031 protein transport --
GO:0044267 cellular protein metabolic process TAS --
GO:0045039 protein import into mitochondrial inner membrane ISS 14726512
genes like me logo Genes that share ontologies with TIMM9: view

No data available for SIGNOR curated interactions for TIMM9 Gene

Drugs & Compounds for TIMM9 Gene

No Compound Related Data Available

Transcripts for TIMM9 Gene

Unigene Clusters for TIMM9 Gene

Translocase of inner mitochondrial membrane 9 homolog (yeast):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - -
SP7:
SP8: - - -

Relevant External Links for TIMM9 Gene

GeneLoc Exon Structure for
TIMM9
ECgene alternative splicing isoforms for
TIMM9

Expression for TIMM9 Gene

mRNA expression in normal human tissues for TIMM9 Gene

Protein differential expression in normal tissues from HIPED for TIMM9 Gene

This gene is overexpressed in Fetal Brain (7.7) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM9 Gene



SOURCE GeneReport for Unigene cluster for TIMM9 Gene Hs.440525

mRNA Expression by UniProt/SwissProt for TIMM9 Gene

Q9Y5J7-TIM9_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
genes like me logo Genes that share expression patterns with TIMM9: view

Protein tissue co-expression partners for TIMM9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TIMM9 Gene

Orthologs for TIMM9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIMM9 35
  • 95.88 (n)
  • 100 (a)
TIMM9 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM9 35
  • 95.51 (n)
  • 98.88 (a)
TIMM9 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm9 35
  • 92.51 (n)
  • 97.75 (a)
Timm9 16
Timm9 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIMM9 35
  • 100 (n)
  • 100 (a)
TIMM9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm9 35
  • 93.63 (n)
  • 98.88 (a)
oppossum
(Monodelphis domestica)
Mammalia TIMM9 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIMM9 35
  • 83.52 (n)
  • 88.76 (a)
lizard
(Anolis carolinensis)
Reptilia TIMM9 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1073 35
timm9 35
  • 78.65 (n)
  • 93.26 (a)
zebrafish
(Danio rerio)
Actinopterygii timm9 35
  • 79.4 (n)
  • 93.26 (a)
timm9 36
  • 93 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9815 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000781 35
  • 53.01 (n)
  • 50.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tim9a 35
  • 56.12 (n)
  • 58.23 (a)
Tim9a 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tin-9.1 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM9 36
  • 37 (a)
OneToOne
Species with no ortholog for TIMM9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM9 Gene

ENSEMBL:
Gene Tree for TIMM9 (if available)
TreeFam:
Gene Tree for TIMM9 (if available)

Paralogs for TIMM9 Gene

(3) SIMAP similar genes for TIMM9 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TIMM9 Gene

genes like me logo Genes that share paralogs with TIMM9: view

No data available for Paralogs for TIMM9 Gene

Variants for TIMM9 Gene

Sequence variations from dbSNP and Humsavar for TIMM9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2348076 -- 58,417,897(+) catta(A/C)tacag intron-variant
rs4635255 -- 58,417,770(+) gcaga(A/G)atcaa intron-variant
rs4901857 -- 58,418,621(+) ataag(C/T)atatt intron-variant
rs7157625 -- 58,422,656(+) AAAGT(C/T)TGTCA intron-variant
rs10146336 -- 58,418,143(+) gttta(C/T)tccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM9 Gene

Variant ID Type Subtype PubMed ID
nsv901985 CNV Loss 21882294

Variation tolerance for TIMM9 Gene

Residual Variation Intolerance Score: 57.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM9 Gene

HapMap Linkage Disequilibrium report
TIMM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM9 Gene

Disorders for TIMM9 Gene

Relevant External Links for TIMM9

Genetic Association Database (GAD)
TIMM9
Human Genome Epidemiology (HuGE) Navigator
TIMM9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM9
genes like me logo Genes that share disorders with TIMM9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM9 Gene

Publications for TIMM9 Gene

  1. Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. (PMID: 19037098) Baker M.J. … Ryan M.T. (Mol. Biol. Cell 2009) 23 67
  2. Allosteric and electrostatic protein-protein interactions regulate the assembly of the heterohexameric Tim9-Tim10 complex. (PMID: 18462749) Ivanova E. … Lu H. (J. Mol. Biol. 2008) 23 67
  3. The structural basis of the TIM10 chaperone assembly. (PMID: 14973126) Lu H. … Tokatlidis K. (J. Biol. Chem. 2004) 23 67
  4. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Muehlenbein N. … Bauer M.F. (J. Biol. Chem. 2004) 2 67
  5. Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. (PMID: 12882976) Allen S. … Tokatlidis K. (J. Biol. Chem. 2003) 23 67

Products for TIMM9 Gene

Sources for TIMM9 Gene

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