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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMM9 Gene

protein-coding   GIFtS: 56
GCID: GC14M058875

Translocase Of Inner Mitochondrial Membrane 9 Homolog (Yeast)

(Previous name: translocase of inner mitochondrial membrane 9 (yeast) homolog)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocase Of Inner Mitochondrial Membrane 9 Homolog (Yeast)1 2
TIM92 3 5
TIM9A2 3
Translocase Of Inner Mitochondrial Membrane 9 (Yeast) Homolog1
Mitochondrial Import Inner Membrane Translocase Subunit Tim92
TIMM9A3

External Ids:    HGNC: 118191   Entrez Gene: 265202   Ensembl: ENSG000001005757   OMIM: 6073845   UniProtKB: Q9Y5J73   

Export aliases for TIMM9 gene to outside databases

Previous GC identifers: GC14M056199 GC14M052671 GC14M056865 GC14M057946 GC14M039039


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIMM9 Gene:
TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in
the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane
proteins into the mitochondrial inner membrane.(supplied by OMIM, Apr 2004)

GeneCards Summary for TIMM9 Gene: 
TIMM9 (translocase of inner mitochondrial membrane 9 homolog (yeast)) is a protein-coding gene. Diseases associated with TIMM9 include familial deafness, and among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include chaperone binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: TIM9_HUMAN, Q9Y5J7
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass
transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of
beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer
membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide
them through the mitochondrial intermembrane space

Gene Wiki entry for TIMM9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMM9 gene promoter:
         RFX1   p53   Pax-2   Pax-2a   MIF-1   GATA-1   HNF-1A   IRF-2   FOXO4   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMM9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q22.3-q24

TIMM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M058875:  view genomic region     (about GC identifiers)

Start:
58,875,212 bp from pter      End:
58,894,332 bp from pter
Size:
19,121 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIM9_HUMAN, Q9Y5J7 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim9  
Size: 89 amino acids; 10378 Da
Subunit: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex.
The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22
complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9,
TIMM10/TIM10A and FXC1/TIM10B
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
1 PDB 3D structure from and Proteopedia for TIMM9:
2BSK (3D)    
Secondary accessions: B2R584

Explore the universe of human proteins at neXtProt for TIMM9: NX_Q9Y5J7

Explore proteomics data for TIMM9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5J7

  • TIMM9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMM9 Protein Expression
    REFSEQ proteins: NP_036592.1  
    ENSEMBL proteins: 
     ENSP00000378588   ENSP00000451006   ENSP00000452091   ENSP00000450638   ENSP00000451198  
     ENSP00000450624  
    Reactome Protein details: Q9Y5J7
    Human Recombinant Protein Products for TIMM9: 
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    Novus Biologicals TIMM9 Proteins
    Novus Biologicals TIMM9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIMM9 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005758mitochondrial intermembrane space TAS14726512
    GO:0042719mitochondrial intermembrane space protein transporter complex TAS10552927

    TIMM9 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for TIMM9 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004217 Tim10/DDP_fam_Znf

    Graphical View of Domain Structure for InterPro Entry Q9Y5J7

    ProtoNet protein and cluster: Q9Y5J7

    1 Blocks protein domain: IPB004217 Zn-finger

    UniProtKB/Swiss-Prot: TIM9_HUMAN, Q9Y5J7
    Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial
    intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues
    probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer
    membrane (Probable)
    Similarity: Belongs to the small Tim family


    TIMM9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM9_HUMAN, Q9Y5J7
    Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass
    transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of
    beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer
    membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide
    them through the mitochondrial intermembrane space

         Genatlas biochemistry entry for TIMM9:
    translocase of inner mitochondrial membrane 9 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S
    cerevisiae Tim9p ortholog,complexing with Tim10p and essential for escorting a class of multimembrane-spanning
    proteins

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IDA16387659
    GO:0005515protein binding IPI14726512
    GO:0008270zinc ion binding TAS10552927
    GO:0042803protein homodimerization activity IPI16387659
    GO:0046872metal ion binding ----
         
    TIMM9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TIMM9:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMM9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMM9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMM9 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM9:
    hsa-miR-212 hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidTIMM9 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIMM9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for TIMM9
        Mitochondrial Protein Import
    Metabolism of proteins



    TIMM9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMM9

    3 Interacting proteins for TIMM9 (Q9Y5J71, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIMM10P620721, 3EBI-1200370,EBI-1200391 I2D: score=1 
    TIMM10BQ9Y5J63I2D: score=1 
    TIMM22Q9Y5843I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0007605sensory perception of sound TAS10552927
    GO:0015031protein transport ----
    GO:0044267cellular protein metabolic process TAS--
    GO:0045039protein import into mitochondrial inner membrane ISS14726512

    TIMM9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMM9 (TIM9)

    Search CenterWatch for drugs/clinical trials and news about TIMM9 / TIM9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMM9 gene: 
    NM_012460.2  

    Unigene Cluster for TIMM9:

    Translocase of inner mitochondrial membrane 9 homolog (yeast)
    Hs.440525  [show with all ESTs]
    Unigene Representative Sequence: BG719789
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395159(uc010aph.3 uc001xds.3 uc010api.3) ENST00000216463
    ENST00000555593 ENST00000556007 ENST00000557397 ENST00000555061 ENST00000556367
    ENST00000555930 ENST00000555404 ENST00000555097
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM9:
    hsa-miR-212 hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidTIMM9 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM9

    Additional mRNA sequence: 

    AF150100.1 AF152353.1 AK000666.1 AK312095.1 BC020213.1 BC054875.1 

    7 DOTS entries:

    DT.317242  DT.101968142  DT.97844413  DT.120771745  DT.86853111  DT.120771744  DT.92424218 

    24/154 AceView cDNA sequences (see all 154):

    AI149307 AA576387 BM674782 AI089738 BU158559 AW271818 AA977202 AI143332 
    CR600804 AI609073 C00208 BC054875 AI380149 AW651630 AA513014 AW675671 
    BM985453 AF152353 AA426291 AI743840 AW024571 CB158204 BG291608 BE041685 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM9 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                                              -                                             
    SP2:                                                  -           -                                             
    SP3:                          -     -     -                       -                                             
    SP4:                                                              -     -                                       
    SP5:                          -     -     -     -                 -                                             


    ECgene alternative splicing isoforms for TIMM9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMM9 expression in normal human tissues (normalized intensities)      TIMM9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAGATAG
    TIMM9 Expression
    About this image


    TIMM9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex

    See TIMM9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMM9

    SOURCE GeneReport for Unigene cluster: Hs.440525

    UniProtKB/Swiss-Prot: TIM9_HUMAN, Q9Y5J7
    Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including TIMM9: 
              Mitochondria in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TIMM9 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm91 , 5 translocase of inner mitochondrial membrane 9 homolog more5
    translocase of inner mitochondrial membrane 91
    92.51(n)1
    97.75(a)1
      12 (29.39 cM)5
    300561  NM_001024853.11  NP_001020024.11 
     711231735 
    chicken
    (Gallus gallus)
    Aves TIMM91 translocase of inner mitochondrial membrane 9 homolog more 83.52(n)
    88.76(a)
      100859762  XM_003641420.1  XP_003641468.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIMM96
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343459.1(412358-420318)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.10732 Transcribed sequence with strong similarity to protein more 78.38(n)    137696496 
    zebrafish
    (Danio rerio)
    Actinopterygii timm92 translocase of inner mitochondrial membrane 9 homolog 79.49(n)   282678  AF150107.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tim9a1 CG1660-PA 56.12(n)
    58.23(a)
      32294  NM_132653.2  NP_572881.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tin-9.16
    Mitochondrial import inner membrane translocase su...
    37(a)
    1 ↔ 1
    IV(7043935-7044604)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIM96
    Essential protein of the mitochondrial intermembra...
    40(a)
    1 ↔ 1
    V(117211-117474)


    ENSEMBL Gene Tree for TIMM9 (if available)
    TreeFam Gene Tree for TIMM9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMM9 gene
    3 SIMAP similar genes for TIMM9 using alignment to 4 protein entries:     TIM9_HUMAN (see all proteins):
    FXC1    TIMM10B    TIMM10

    TIMM9 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TIMM9
    PGOHUM00000238535 PGOHUM00000248390 PGOHUM00000239177


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/363 SNPs in TIMM9 are shown (see all 363)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421262241,2
    C--39043739(+) GCCTGC/TCTCGG 1 -- int10--------
    rs1463722161,2
    C--39043780(+) GCCGCC/TGTGCC 1 -- int10--------
    rs1485845471,2
    --39044166(+) AGAATC/TGCTTG 1 -- int10--------
    rs1859062221,2
    --39044283(+) AAAAGA/GAAAAT 1 -- int10--------
    rs71594821,2
    C,H--39044352(+) ACCAAT/ATTGCT 1 -- int114Minor allele frequency- A:0.00NS EA NA WA CSA 788
    rs1129907031,2
    C,F--39044420(+) TAACAT/ATTCAA 1 -- int12Minor allele frequency- A:0.02CSA WA 120
    rs1907195941,2
    --39044422(+) ACATTC/TCAACA 1 -- int10--------
    rs1506038331,2
    --39044533(+) TTGAAC/TGCTAA 1 -- int10--------
    rs1396921981,2
    --39044709(+) ATTAAC/TAGTTA 1 -- int10--------
    rs1446896311,2
    C--39045306(+) TGAGCC/TGAGAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TIMM9 (58875212 - 58894332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TIMM9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901985CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607384    OMIM disorders: --

    2 diseases for TIMM9:    About MalaCards
    familial deafness    


    TIMM9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIMM9
    Human Genome Epidemiology (HuGE) Navigator: TIMM9 (1 document)

    Export disorders for TIMM9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMM9 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with TIMM9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)1, 2, 3 Muhlenbein N....Bauer M.F. (2004)
    2. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PubMed id 10552927)1, 2, 3 Jin H.... Vetrie D.L.P. (1999)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. (PubMed id 16387659)1, 2 Webb C.T.... Gulbis J.M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PubMed id 11489896)1, 2 Rothbauer U.... Bauer M.F. (2001)
    7. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2 Bauer M.F.... Hofmann S. (1999)
    8. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. PKCe promotes oncogenic functions of ATF2 in the nucle us while blocking its apoptotic function at mitochondria. (PubMed id 22304920)1 Lau E....Ronai Z.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26520 HGNC: 11819 AceView: TIMM9 Ensembl:ENSG00000100575 euGenes: HUgn26520
    ECgene: TIMM9 H-InvDB: TIMM9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMM9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMM9 gene:
    Search GeneIP for patents involving TIMM9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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