Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMM44 Gene

protein-coding   GIFtS: 57
GCID: GC19M007991

Translocase Of Inner Mitochondrial Membrane 44 Homolog (Yeast)

  Search for TIMM44
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocase Of Inner Mitochondrial Membrane 44 Homolog (Yeast)1 2
TIM442 3
Mitochondrial Import Inner Membrane Translocase Subunit TIM442
Mitochondrial Inner Membrane Translocase2
MIMT443

External Ids:    HGNC: 173161   Entrez Gene: 104692   Ensembl: ENSG000001049807   OMIM: 6050585   UniProtKB: O436153   

Export aliases for TIMM44 gene to outside databases

Previous GC identifers: GC19M007950 GC19M008097 GC19M007897 GC19M007661


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TIMM44 Gene: 
TIMM44 (translocase of inner mitochondrial membrane 44 homolog (yeast)) is a protein-coding gene. Among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity and ATP binding.

UniProtKB/Swiss-Prot: TIM44_HUMAN, O43615
Function: Essential component of the PAM complex, a complex required for the translocation of transit
peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source

Gene Wiki entry for TIMM44 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_077812.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMM44 gene promoter:
         Pax-2   FOXD1   Pax-2a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   CHOP-10   HEN1   Pax-2b   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM44 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMM44

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

TIMM44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM44 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M007991:  view genomic region     (about GC identifiers)

Start:
7,991,603 bp from pter      End:
8,008,805 bp from pter
Size:
17,203 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIM44_HUMAN, O43615 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit TIM44 precursor  
Size: 452 amino acids; 51356 Da
Subunit: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or
GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). The complex interacts with the TIMM23 component
of the TIM23 complex
Subcellular location: Mitochondrion inner membrane
1 PDB 3D structure from and Proteopedia for TIMM44:
2CW9 (3D)    
Secondary accessions: A8K0R9 D6W664 Q8N193

Explore the universe of human proteins at neXtProt for TIMM44: NX_O43615

Explore proteomics data for TIMM44 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43615

  • TIMM44 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMM44 Protein Expression
    REFSEQ proteins: NP_006342.2  
    ENSEMBL proteins: 
     ENSP00000469273   ENSP00000472916   ENSP00000270538   ENSP00000471596   ENSP00000469389  
    Reactome Protein details: O43615
    Human Recombinant Protein Products for TIMM44: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TIMM44
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TIMM44
    GenScript Custom Purified and Recombinant Proteins Services for TIMM44
    Novus Biologicals TIMM44 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIMM44 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IDA10339406
    GO:0005759mitochondrial matrix IDA10339406

    TIMM44 for ontologies           About GeneDecksing



    TIMM44 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TIMM44
    GenScript Custom Superior Antibodies Services for TIMM44
    Novus Biologicals TIMM44 Antibodies
    Abcam antibodies for TIMM44
    Cloud-Clone Corp. Antibodies for TIMM44 
    Search ThermoFisher Antibodies for TIMM44
    LSBio Antibodies in human, mouse, rat for TIMM44 

    Assay Products for TIMM44: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TIMM44
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIMM44
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIMM44 
    Cloud-Clone Corp. CLIAs for TIMM44


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007379 Tim44-like_dom
     IPR017303 Tim44

    Graphical View of Domain Structure for InterPro Entry O43615

    ProtoNet protein and cluster: O43615

    1 Blocks protein domain: IPB007379 Mitochondrial import inner membrane translocase

    UniProtKB/Swiss-Prot: TIM44_HUMAN, O43615
    Similarity: Belongs to the Tim44 family


    TIMM44 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM44_HUMAN, O43615
    Function: Essential component of the PAM complex, a complex required for the translocation of transit
    peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
    Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12620389
    GO:0005524ATP binding IEA--
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA--
         
    TIMM44 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TIMM44:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMM44 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMM44

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMM44 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMM44 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM44
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TIMM44:
    hsa-miR-1207-3p
    SwitchGear 3'UTR luciferase reporter plasmidTIMM44 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMM44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM44

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMM44
    Sirion Biotech Customized adenovirus for overexpression of TIMM44

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TIMM44 (see all 7)
    OriGene ORF clones in mouse, rat for TIMM44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMM44 (NM_006351)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM44
    Sirion Biotech Customized lentivirus for stable overexpression of TIMM44 
                         Customized lentivirus expression plasmids for stable overexpression of TIMM44 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIMM44
    Search LifeMap BioReagents cell lines for TIMM44
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM44


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIMM44 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for TIMM44
        Mitochondrial Protein Import
    Metabolism of proteins



    TIMM44 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIMM44

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for TIMM44 (O436151, 3 ENSP000002705384) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARAFP103981, 3, ENSP000003662444EBI-861737,EBI-365961 I2D: score=5 STRING: ENSP00000366244
    HSPA9P386463, ENSP000002971854I2D: score=5 STRING: ENSP00000297185
    MOGSQ137243, ENSP000002336164I2D: score=5 STRING: ENSP00000233616
    TIMM17BO608303, ENSP000003657664I2D: score=2 STRING: ENSP00000365766
    HSPD1P108093, ENSP000003400194I2D: score=1 STRING: ENSP00000340019
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--

    TIMM44 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIMM44 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMM44 (TIM44)

    1 Novoseek inferred chemical compound relationship for TIMM44 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 11.2 3 10913171 (2), 11937760 (1)

    Search CenterWatch for drugs/clinical trials and news about TIMM44 / TIM44

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMM44 gene: 
    NM_006351.3  

    Unigene Cluster for TIMM44:

    Translocase of inner mitochondrial membrane 44 homolog (yeast)
    Hs.465784  [show with all ESTs]
    Unigene Representative Sequence: CR627419
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599939 ENST00000595565 ENST00000595831 ENST00000270538(uc002miz.3 uc010dvx.2)
    ENST00000598968 ENST00000599650 ENST00000598481 ENST00000595876 ENST00000598675
    ENST00000597926 ENST00000600748 ENST00000600000
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM44
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TIMM44:
    hsa-miR-1207-3p
    SwitchGear 3'UTR luciferase reporter plasmidTIMM44 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMM44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM44
    Clone
    Products:
         
    OriGene clones in human, mouse for TIMM44 (see all 7)
    OriGene ORF clones in mouse, rat for TIMM44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMM44 (NM_006351)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM44
    Sirion Biotech Customized lentivirus for stable overexpression of TIMM44 
                         Customized lentivirus expression plasmids for stable overexpression of TIMM44 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIMM44
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMM44
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM44
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM44
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM44

    Additional mRNA sequence: 

    AF026030.1 AF041254.1 AK223062.1 AK289634.1 AK309415.1 BC033628.1 CR627419.1 X58234.1 

    21 DOTS entries:

    DT.100820239  DT.442574  DT.100820250  DT.91877673  DT.92047090  DT.100820246  DT.100820248  DT.100757924 
    DT.100820241  DT.100820240  DT.121452024  DT.444529  DT.95202295  DT.100673009  DT.121452045  DT.97808770 
    DT.97861007  DT.121413194  DT.121413268  DT.91668770  DT.95344133 

    24/355 AceView cDNA sequences (see all 355):

    CA417810 BC033628 F27317 CB106779 AI697206 AA505907 AA583279 BE673267 
    AW089104 AI564939 AI936865 BQ649769 BP373084 BM772600 AI201314 BU858296 
    BM744151 BU156877 BM757006 BP376039 NM_006351 T28125 BM770335 CB152340 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMM44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAAGATGA
    TIMM44 Expression
    About this image


    See TIMM44 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMM44

    SOURCE GeneReport for Unigene cluster: Hs.465784
        SABiosciences Expression via Pathway-Focused PCR Array including TIMM44: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TIMM44
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMM44
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM44
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM44
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM44
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM44

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TIMM44 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm441 , 5 translocase of inner mitochondrial membrane 441, 5 84.59(n)1
    89.6(a)1
      8 (1.99 cM)5
    218561  NM_011592.21  NP_035722.21 
     42597315 
    chicken
    (Gallus gallus)
    Aves TIMM441 translocase of inner mitochondrial membrane 44 homolog more 73.92(n)
    83.41(a)
      420053  XM_418174.3  XP_418174.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.138802 Xenopus laevis transcribed sequence with moderate similarity more 73.92(n)    48048821 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005379101 mitochondrial import inner membrane translocase subunit more 73.68(n)
    83.21(a)
      100537910  XM_003200953.1  XP_003201001.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117791 CG11779 59.71(n)
    52.67(a)
      42298  NM_142529.3  NP_650786.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T09B4.91 , 3 Protein T09B4.91 43(a)3
    50.26(n)1
    44.3(a)1
      I(6186307-6188905)3
    1723021  NM_059379.21  NP_491780.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIM44(YIL022W)4
    TIM441
    Essential component of the Translocase of the Inner more4
    Tim44p1
    45.67(n)1
    30.56(a)1
      9(311165-312460)4
    8547901, 4  NP_012242.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TIM44-21 translocase inner membrane subunit 44-2 39.93(n)
    26.32(a)
      818180  NM_129166.4  NP_181151.3 
    rice
    (Oryza sativa)
    Liliopsida Os07g04097001 hypothetical protein 39.74(n)
    29.66(a)
      4343001  NM_001065978.1  NP_001059443.1 


    ENSEMBL Gene Tree for TIMM44 (if available)
    TreeFam Gene Tree for TIMM44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMM44 gene
    2 SIMAP similar genes for TIMM44 using alignment to 5 protein entries:     TIM44_HUMAN (see all proteins):
    DKFZp686H05241    hTIM44

    TIMM44 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/483 SNPs in TIMM44 are shown (see all 483)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016775861,2
    --7993069(+) GCCGAC/TACGCC 1 -- int10--------
    rs1453675771,2
    --7993142(+) CCCAGA/GTGCCC 1 -- int10--------
    rs1826057731,2
    --7993326(+) ATCCCA/CAATCT 1 -- int10--------
    rs1156031491,2
    C,F--7993386(+) TATTCG/ACCGCA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1888512681,2
    --7993417(+) TCAAAC/TGCCTC 1 -- int10--------
    rs1380000731,2
    --7993580(+) AGAAAA/CGATGT 1 -- int10--------
    rs1932279121,2
    C--7993628(+) GCGGAA/GGGGAG 1 -- int10--------
    rs1469591441,2
    C--7993635(+) GAGAG-/AAAAAA 1 -- int10--------
    rs1162424541,2
    C,F--7993666(+) TTGTTC/TGGTTT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1425971531,2
    --7993734(+) TTCCAA/GGGCAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TIMM44 (7991603 - 8008805 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TIMM44:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3716n71CNV Loss21882294
    nsv910990CNV Loss21882294
    nsv910989CNV Loss21882294
    dgv3715n71CNV Loss21882294
    nsv910993CNV Loss21882294
    nsv833733CNV Gain17160897


    Human Gene Mutation Database (HGMD): TIMM44
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMM44
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM44

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TIMM44 for disorders           About MalaCards
    OMIM gene information: 605058    OMIM disorders: --


    TIMM44 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TIMM44 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 41 3 16107694 (1), 10913171 (1), 15218029 (1)

    Genetic Association Database (GAD): TIMM44
    Human Genome Epidemiology (HuGE) Navigator: TIMM44 (1 document)

    Export disorders for TIMM44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMM44 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with TIMM44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PubMed id 10339406)1, 2, 3, 9 Bauer M.F.... Hofmann S. (1999)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Isoform-specific localization of A-RAF in mitochondria. (PubMed id 10848612)1, 3 Yuryev A.... Wennogle L.P. (2000)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Proteome analysis of the thalamus and cerebrospinal f luid reveals glycolysis dysfunction and potential biomarkers candidates for sch izophrenia. (PubMed id 20471030)1 Martins-de-Souza D....Turck C.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10469 HGNC: 17316 AceView: TIMM44andCTXN1 Ensembl:ENSG00000104980 euGenes: HUgn10469
    ECgene: TIMM44 H-InvDB: TIMM44

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMM44 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM44 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMM44 gene:
    Search GeneIP for patents involving TIMM44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TIMM44  
     OriGene qPCR primer pairs and template standards for TIMM44   OriGene Protein Over-expression Lysate for TIMM44  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TIMM44  
     OriGene qSTAR qPCR primer pairs in human, mouse for TIMM44   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TIMM44   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TIMM44   OriGene Custom Protein Services for TIMM44  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMM44
     QIAGEN SeqTarget long-range PCR primers for resequencing TIMM44
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM44
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM44
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM44
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM44
     GenScript Custom Purified and Recombinant Proteins Services for TIMM44 GenScript cDNA clones with any tag delivered in your preferred vector for TIMM44
     GenScript Custom Assay Services for TIMM44 GenScript Custom Superior Antibodies Services for TIMM44
     GenScript Custom overexpressing Cell Line Services for TIMM44 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TIMM44 promoter
     Search Chromatin IP Primers for TIMM44
     RT2 qPCR Primer Assay in human, mouse, rat TIMM44
     Search GNC Networks for TIMM44
     SABiosciences PCR Arrays including human, mouse, rat TIMM44
     Search Tocris compounds for TIMM44 (TIM44)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TIMM44 antibodies
     TIMM44 lysates
     Antibodies for TIMM44
     See all of Abcam's Antibodies, Kits and Proteins for TIMM44
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TIMM44
     Antibodies for TIMM44
     ELISAs for TIMM44
     CLIAs for TIMM44
     Search LifeMap BioReagents cell lines for TIMM44
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM44
     SwitchGear 3'UTR luciferase reporter plasmids for TIMM44
     SwitchGear Promoter luciferase reporter plasmids for TIMM44
     Search ThermoFisher Antibodies for TIMM44
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM44
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMM44
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMM44
    Customized:
     lentivirus for stable overexpression of TIMM44
     lentivirus expression plasmids for stable overexpression of TIMM44
     adenovirus for overexpression of TIMM44
     LSBio Antibodies in human, mouse, rat for TIMM44
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TIMM44 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4