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Aliases for TIMM44 Gene

Aliases for TIMM44 Gene

  • Translocase Of Inner Mitochondrial Membrane 44 2 3
  • Translocase Of Inner Mitochondrial Membrane 44 Homolog (Yeast) 2 5
  • TIM44 3 4
  • 36/8-5 Fusion Protein With Epitope For Anti-Lectin Antibody 3
  • Translocase Of Inner Mitochondrial Membrane 44 Homolog 3
  • Mitochondrial Inner Membrane Translocase 3
  • MIMT44 4

External Ids for TIMM44 Gene

Previous GeneCards Identifiers for TIMM44 Gene

  • GC19M007950
  • GC19M008097
  • GC19M007897
  • GC19M007991
  • GC19M007661

Summaries for TIMM44 Gene

GeneCards Summary for TIMM44 Gene

TIMM44 (Translocase Of Inner Mitochondrial Membrane 44) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. GO annotations related to this gene include chaperone binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for TIMM44 Gene

  • Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.

Gene Wiki entry for TIMM44 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM44 Gene

Genomics for TIMM44 Gene

Regulatory Elements for TIMM44 Gene

Promoters for TIMM44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIMM44 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIMM44 Gene

Chromosome:
19
Start:
7,926,718 bp from pter
End:
7,943,920 bp from pter
Size:
17,203 bases
Orientation:
Minus strand

Genomic View for TIMM44 Gene

Genes around TIMM44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM44 Gene

Proteins for TIMM44 Gene

  • Protein details for TIMM44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43615-TIM44_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit TIM44
    Protein Accession:
    O43615
    Secondary Accessions:
    • A8K0R9
    • D6W664
    • Q8N193

    Protein attributes for TIMM44 Gene

    Size:
    452 amino acids
    Molecular mass:
    51356 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). The complex interacts with the TIMM23 component of the TIM23 complex.

    Three dimensional structures from OCA and Proteopedia for TIMM44 Gene

neXtProt entry for TIMM44 Gene

Proteomics data for TIMM44 Gene at MOPED

Post-translational modifications for TIMM44 Gene

  • Ubiquitination at Lys 240, Lys 246, and Lys 264
  • Modification sites at PhosphoSitePlus

Other Protein References for TIMM44 Gene

No data available for DME Specific Peptides for TIMM44 Gene

Domains & Families for TIMM44 Gene

Suggested Antigen Peptide Sequences for TIMM44 Gene

Graphical View of Domain Structure for InterPro Entry

O43615

UniProtKB/Swiss-Prot:

TIM44_HUMAN :
  • Belongs to the Tim44 family.
Family:
  • Belongs to the Tim44 family.
genes like me logo Genes that share domains with TIMM44: view

No data available for Gene Families for TIMM44 Gene

Function for TIMM44 Gene

Molecular function for TIMM44 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.

Gene Ontology (GO) - Molecular Function for TIMM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TIMM44: view

Phenotypes for TIMM44 Gene

genes like me logo Genes that share phenotypes with TIMM44: view

Animal Model Products

CRISPR Products

miRNA for TIMM44 Gene

miRTarBase miRNAs that target TIMM44

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM44 Gene

Localization for TIMM44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM44 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM44 Gene COMPARTMENTS Subcellular localization image for TIMM44 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for TIMM44 Gene

Pathways & Interactions for TIMM44 Gene

genes like me logo Genes that share pathways with TIMM44: view

Pathways by source for TIMM44 Gene

2 Reactome pathways for TIMM44 Gene

Gene Ontology (GO) - Biological Process for TIMM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TIMM44: view

No data available for SIGNOR curated interactions for TIMM44 Gene

Drugs & Compounds for TIMM44 Gene

(1) Drugs for TIMM44 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TIMM44: view

Transcripts for TIMM44 Gene

Unigene Clusters for TIMM44 Gene

Translocase of inner mitochondrial membrane 44 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM44 Gene

No ASD Table

Relevant External Links for TIMM44 Gene

GeneLoc Exon Structure for
TIMM44
ECgene alternative splicing isoforms for
TIMM44

Expression for TIMM44 Gene

mRNA expression in normal human tissues for TIMM44 Gene

Protein differential expression in normal tissues from HIPED for TIMM44 Gene

This gene is overexpressed in Bone (10.7), Peripheral blood mononuclear cells (9.8), and Salivary gland (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM44 Gene



SOURCE GeneReport for Unigene cluster for TIMM44 Gene Hs.465784

genes like me logo Genes that share expression patterns with TIMM44: view

Protein tissue co-expression partners for TIMM44 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIMM44 Gene

Orthologs for TIMM44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM44 35
  • 99.26 (n)
  • 99.56 (a)
TIMM44 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIMM44 36
  • 91 (a)
OneToOne
TIMM44 35
  • 87.66 (n)
  • 91.8 (a)
dog
(Canis familiaris)
Mammalia TIMM44 35
  • 89.06 (n)
  • 93.35 (a)
TIMM44 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm44 35
  • 84.59 (n)
  • 89.6 (a)
Timm44 36
  • 90 (a)
OneToOne
Timm44 16
oppossum
(Monodelphis domestica)
Mammalia TIMM44 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM44 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm44 35
  • 83.85 (n)
  • 90.27 (a)
chicken
(Gallus gallus)
Aves TIMM44 36
  • 81 (a)
OneToOne
TIMM44 35
  • 73.97 (n)
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13880 35
tropical clawed frog
(Silurana tropicalis)
Amphibia timm44 35
  • 69.98 (n)
  • 81.09 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537910 35
  • 70.19 (n)
  • 76.85 (a)
timm44 36
  • 75 (a)
OneToMany
timm44 36
  • 75 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000291 35
  • 62.87 (n)
  • 54.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11779 36
  • 46 (a)
OneToOne
CG11779 35
  • 59.15 (n)
  • 52.28 (a)
worm
(Caenorhabditis elegans)
Secernentea T09B4.9 36
  • 43 (a)
OneToOne
T09B4.9 37
  • 43 (a)
T09B4.9 35
  • 49.28 (n)
  • 43.27 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL118C 35
  • 47.26 (n)
  • 28.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM44 36
  • 25 (a)
OneToOne
TIM44 38
TIM44 35
  • 45.63 (n)
  • 30.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16214g 35
  • 42.58 (n)
  • 28.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03229 35
  • 46.92 (n)
  • 31.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tim44 35
  • 42.07 (n)
  • 29.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2213 36
  • 40 (a)
OneToOne
Species with no ortholog for TIMM44:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM44 Gene

ENSEMBL:
Gene Tree for TIMM44 (if available)
TreeFam:
Gene Tree for TIMM44 (if available)

Paralogs for TIMM44 Gene

(2) SIMAP similar genes for TIMM44 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIMM44: view

No data available for Paralogs for TIMM44 Gene

Variants for TIMM44 Gene

Sequence variations from dbSNP and Humsavar for TIMM44 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs545364 -- 7,938,665(-) catgc(C/G)cagct intron-variant
rs550030 -- 7,941,288(-) GAGTT(C/G)CAGGT intron-variant
rs1002066 -- 7,945,050(-) AGGTC(C/T)TCACT upstream-variant-2KB
rs3745387 -- 7,935,219(+) GGAGT(A/G)CAGTG intron-variant
rs3745388 -- 7,935,261(+) GCCAG(A/G)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM44 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv910993 CNV Loss 21882294

Variation tolerance for TIMM44 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM44 Gene

HapMap Linkage Disequilibrium report
TIMM44
Human Gene Mutation Database (HGMD)
TIMM44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM44 Gene

Disorders for TIMM44 Gene

Relevant External Links for TIMM44

Genetic Association Database (GAD)
TIMM44
Human Genome Epidemiology (HuGE) Navigator
TIMM44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM44

No disorders were found for TIMM44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM44 Gene

Publications for TIMM44 Gene

  1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PMID: 10339406) Bauer M.F. … Hofmann S. (J. Mol. Biol. 1999) 2 3 4 23 67
  2. Isoform-specific localization of A-RAF in mitochondria. (PMID: 10848612) Yuryev A. … Wennogle L.P. (Mol. Cell. Biol. 2000) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes. (PMID: 25749183) Wang Y. … Wada J. (Metab. Clin. Exp. 2015) 3

Products for TIMM44 Gene

Sources for TIMM44 Gene

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