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Aliases for TIMM44 Gene

Aliases for TIMM44 Gene

  • Translocase Of Inner Mitochondrial Membrane 44 Homolog (Yeast) 2 3
  • TIM44 3 4
  • Mitochondrial Import Inner Membrane Translocase Subunit TIM44 3
  • Mitochondrial Inner Membrane Translocase 3
  • MIMT44 4

External Ids for TIMM44 Gene

Summaries for TIMM44 Gene

GeneCards Summary for TIMM44 Gene

TIMM44 (Translocase Of Inner Mitochondrial Membrane 44 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for TIMM44 Gene

  • Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source

Gene Wiki entry for TIMM44 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM44 Gene

Genomics for TIMM44 Gene

Genomic Location for TIMM44 Gene

Start:
7,926,718 bp from pter
End:
7,943,920 bp from pter
Size:
17,203 bases
Orientation:
Minus strand

Genomic View for TIMM44 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM44 Gene

Regulatory Elements for TIMM44 Gene

Proteins for TIMM44 Gene

  • Protein details for TIMM44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43615-TIM44_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit TIM44
    Protein Accession:
    O43615
    Secondary Accessions:
    • A8K0R9
    • D6W664
    • Q8N193

    Protein attributes for TIMM44 Gene

    Size:
    452 amino acids
    Molecular mass:
    51356 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). The complex interacts with the TIMM23 component of the TIM23 complex.

    Three dimensional structures from OCA and Proteopedia for TIMM44 Gene

neXtProt entry for TIMM44 Gene

Proteomics data for TIMM44 Gene at MOPED

Post-translational modifications for TIMM44 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys240, Lys246, and Lys264

Other Protein References for TIMM44 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM44 Gene

Domains for TIMM44 Gene

Protein Domains for TIMM44 Gene

UniProtKB/Swiss-Prot:

TIM44_HUMAN
Family:
  • Belongs to the Tim44 family.:
    • O43615
genes like me logo Genes that share domains with TIMM44: view

No data available for Gene Families for TIMM44 Gene

Function for TIMM44 Gene

Molecular function for TIMM44 Gene

UniProtKB/Swiss-Prot Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source

Gene Ontology (GO) - Molecular Function for TIMM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12620389
GO:0005524 ATP binding IEA --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
GO:0051087 chaperone binding IBA --
genes like me logo Genes that share ontologies with TIMM44: view

Phenotypes for TIMM44 Gene

GenomeRNAi human phenotypes for TIMM44:
genes like me logo Genes that share phenotypes with TIMM44: view

miRNA for TIMM44 Gene

miRTarBase miRNAs that target TIMM44

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIMM44 Gene

Localization for TIMM44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM44 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM44 Gene COMPARTMENTS Subcellular localization image for TIMM44 gene
Compartment Confidence
mitochondrion 5
nucleus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TIMM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IDA 10339406
GO:0005759 mitochondrial matrix IDA 10339406
genes like me logo Genes that share ontologies with TIMM44: view

Pathways for TIMM44 Gene

genes like me logo Genes that share pathways with TIMM44: view

Pathways by source for TIMM44 Gene

2 Reactome pathways for TIMM44 Gene

Gene Ontology (GO) - Biological Process for TIMM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006886 intracellular protein transport --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0044267 cellular protein metabolic process TAS --
GO:0071806 protein transmembrane transport --
genes like me logo Genes that share ontologies with TIMM44: view

Compounds for TIMM44 Gene

(1) Novoseek inferred chemical compound relationships for TIMM44 Gene

Compound -log(P) Hits PubMed IDs
atp 11.2 3
genes like me logo Genes that share compounds with TIMM44: view

Transcripts for TIMM44 Gene

Unigene Clusters for TIMM44 Gene

Translocase of inner mitochondrial membrane 44 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM44 Gene

No ASD Table

Relevant External Links for TIMM44 Gene

GeneLoc Exon Structure for
TIMM44
ECgene alternative splicing isoforms for
TIMM44

Expression for TIMM44 Gene

mRNA expression in normal human tissues for TIMM44 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM44 Gene

SOURCE GeneReport for Unigene cluster for TIMM44 Gene Hs.465784

genes like me logo Genes that share expressions with TIMM44: view

Orthologs for TIMM44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM44 36
  • 99.26 (n)
  • 99.56 (a)
TIMM44 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIMM44 36
  • 87.66 (n)
  • 91.8 (a)
TIMM44 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM44 36
  • 89.06 (n)
  • 93.35 (a)
TIMM44 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm44 36
  • 84.59 (n)
  • 89.6 (a)
Timm44 16
Timm44 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM44 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM44 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm44 36
  • 83.85 (n)
  • 90.27 (a)
chicken
(Gallus gallus)
Aves TIMM44 36
  • 73.97 (n)
  • 83 (a)
TIMM44 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13880 36
tropical clawed frog
(Silurana tropicalis)
Amphibia timm44 36
  • 69.98 (n)
  • 81.09 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537910 36
  • 70.19 (n)
  • 76.85 (a)
timm44 37
  • 75 (a)
OneToMany
timm44 37
  • 75 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000291 36
  • 62.87 (n)
  • 54.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11779 36
  • 59.15 (n)
  • 52.28 (a)
CG11779 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T09B4.9 36
  • 49.28 (n)
  • 43.27 (a)
T09B4.9 37
  • 43 (a)
OneToOne
T09B4.9 38
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL118C 36
  • 47.26 (n)
  • 28.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM44 36
  • 45.63 (n)
  • 30.48 (a)
TIM44 37
  • 25 (a)
OneToOne
TIM44 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16214g 36
  • 42.58 (n)
  • 28.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03229 36
  • 46.92 (n)
  • 31.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tim44 36
  • 42.07 (n)
  • 29.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2213 37
  • 40 (a)
OneToOne
Species with no ortholog for TIMM44:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM44 Gene

ENSEMBL:
Gene Tree for TIMM44 (if available)
TreeFam:
Gene Tree for TIMM44 (if available)

Paralogs for TIMM44 Gene

Selected SIMAP similar genes for TIMM44 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIMM44: view

No data available for Paralogs for TIMM44 Gene

Variants for TIMM44 Gene

Sequence variations from dbSNP and Humsavar for TIMM44 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs520586 -- 7,935,572(-) TGCAG(A/G)CAGGT intron-variant
rs545364 -- 7,938,665(-) catgc(C/G)cagct intron-variant
rs550030 -- 7,941,288(-) GAGTT(C/G)CAGGT intron-variant
rs560467 -- 7,935,574(-) CATGC(A/T)GACAG intron-variant
rs568612 -- 7,941,287(-) AGTTC(C/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM44 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv910993 CNV Loss 21882294

Relevant External Links for TIMM44 Gene

HapMap Linkage Disequilibrium report
TIMM44
Human Gene Mutation Database (HGMD)
TIMM44

Disorders for TIMM44 Gene

(1) Novoseek inferred disease relationships for TIMM44 Gene

Disease -log(P) Hits PubMed IDs
shock 41 3

Relevant External Links for TIMM44

Genetic Association Database (GAD)
TIMM44
Human Genome Epidemiology (HuGE) Navigator
TIMM44
genes like me logo Genes that share disorders with TIMM44: view

No data available for UniProtKB/Swiss-Prot for TIMM44 Gene

Publications for TIMM44 Gene

  1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PMID: 10339406) Bauer M.F. … Hofmann S. (J. Mol. Biol. 1999) 2 3 4 23
  2. Isoform-specific localization of A-RAF in mitochondria. (PMID: 10848612) Yuryev A. … Wennogle L.P. (Mol. Cell. Biol. 2000) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TIMM44 Gene

Sources for TIMM44 Gene

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