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Aliases for TIMM29 Gene

Aliases for TIMM29 Gene

  • Translocase Of Inner Mitochondrial Membrane 29 2 3 5
  • C19orf52 3 4
  • Chromosome 19 Open Reading Frame 52 2
  • Uncharacterized Protein C19orf52 3
  • TIM29 3

External Ids for TIMM29 Gene

Previous HGNC Symbols for TIMM29 Gene

  • C19orf52

Summaries for TIMM29 Gene

GeneCards Summary for TIMM29 Gene

TIMM29 (Translocase Of Inner Mitochondrial Membrane 29) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM29 Gene

Genomics for TIMM29 Gene

Regulatory Elements for TIMM29 Gene

Enhancers for TIMM29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010100 1.2 FANTOM5 ENCODE 40.9 -824.3 -824346 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F011317 0.5 Ensembl ENCODE 37.7 +393.0 392950 9.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF627 ZNF136 ZNF844 ZNF625 ENSG00000267174 ZNF44 ZNF441 ZNF491 ZNF700 ZNF763
GH19F011531 1.5 FANTOM5 Ensembl ENCODE 37.7 +603.7 603706 1.6 PKNOX1 ATF1 ZFP64 ZNF493 FOS ZNF202 ZNF263 REST ZNF518A ZNF623 ZNF627 ZNF136 ZNF844 ZNF442 ZNF625 ZNF44 ZNF799 ZNF441 ZNF491 ZNF700
GH19F011420 1.1 Ensembl ENCODE 37.7 +493.1 493111 3.1 ATF1 PKNOX1 ZNF493 ZFP64 SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ZNF627 ZNF136 ZNF442 ZNF844 ZNF625 ZNF44 ZNF799 ZNF763 ZNF441 ZNF491
GH19F010379 0.2 ENCODE 35.3 -548.2 -548207 1.9 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FBXL12 ZNF561 LOC100419831 RAVER1 TIMM29 ZNF426 YIPF2 ZNF121 ZNF562 EIF3G
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TIMM29 on UCSC Golden Path with GeneCards custom track

Promoters for TIMM29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042990 67 2001 PKNOX1 CREB3L1 WRNIP1 SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13

Genomic Location for TIMM29 Gene

Chromosome:
19
Start:
10,928,733 bp from pter
End:
10,933,535 bp from pter
Size:
4,803 bases
Orientation:
Plus strand

Genomic View for TIMM29 Gene

Genes around TIMM29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM29 Gene

Proteins for TIMM29 Gene

  • Protein details for TIMM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSF4-CS052_HUMAN
    Recommended name:
    Uncharacterized protein C19orf52
    Protein Accession:
    Q9BSF4
    Secondary Accessions:
    • Q96EY6
    • Q96IT8

    Protein attributes for TIMM29 Gene

    Size:
    260 amino acids
    Molecular mass:
    29233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIMM29 Gene

Post-translational modifications for TIMM29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM29 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM29 Gene

Domains & Families for TIMM29 Gene

Gene Families for TIMM29 Gene

Protein Domains for TIMM29 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIMM29: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TIMM29 Gene

Function for TIMM29 Gene

Gene Ontology (GO) - Molecular Function for TIMM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27554484
genes like me logo Genes that share ontologies with TIMM29: view

Phenotypes for TIMM29 Gene

GenomeRNAi human phenotypes for TIMM29:
genes like me logo Genes that share phenotypes with TIMM29: view

Animal Model Products

miRNA for TIMM29 Gene

miRTarBase miRNAs that target TIMM29

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM29 Gene

Localization for TIMM29 Gene

Gene Ontology (GO) - Cellular Components for TIMM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IDA 27554484
GO:0005758 mitochondrial intermembrane space IDA 27554484
GO:0042721 mitochondrial inner membrane protein insertion complex IDA 27554484
genes like me logo Genes that share ontologies with TIMM29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TIMM29 Gene

Pathways & Interactions for TIMM29 Gene

SuperPathways for TIMM29 Gene

No Data Available

Interacting Proteins for TIMM29 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270502%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9BSF4-CS052_HUMAN ENSP00000270502 for TIMM29 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TIMM29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIMM29 Gene

Transcripts for TIMM29 Gene

mRNA/cDNA for TIMM29 Gene

Unigene Clusters for TIMM29 Gene

Chromosome 19 open reading frame 52:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM29 Gene

No ASD Table

Relevant External Links for TIMM29 Gene

GeneLoc Exon Structure for
TIMM29
ECgene alternative splicing isoforms for
TIMM29

Expression for TIMM29 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMM29 Gene:

TIMM29

SOURCE GeneReport for Unigene cluster for TIMM29 Gene:

Hs.164026
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TIMM29 Gene

Orthologs for TIMM29 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf52 34
  • 99.36 (n)
C19orf52 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf52 34
  • 86.41 (n)
C19orf52 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf52 34 35
  • 85.26 (n)
mouse
(Mus musculus)
Mammalia 1810026J23Rik 34 16 35
  • 79.36 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309188 34
  • 78.85 (n)
oppossum
(Monodelphis domestica)
Mammalia C19orf52 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf52 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf52 34
  • 59.74 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:110046 34
  • 52.38 (n)
C3H19orf52 35
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001454 34
  • 48.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14270 34 35
  • 46.85 (n)
worm
(Caenorhabditis elegans)
Secernentea R04F11.5 35
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for TIMM29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM29 Gene

ENSEMBL:
Gene Tree for TIMM29 (if available)
TreeFam:
Gene Tree for TIMM29 (if available)

Paralogs for TIMM29 Gene

No data available for Paralogs for TIMM29 Gene

Variants for TIMM29 Gene

Sequence variations from dbSNP and Humsavar for TIMM29 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111975473 -- 10,926,834(+) TTTTC(G/T)ATTTT intron-variant, upstream-variant-2KB
rs112215927 -- 10,930,279(+) TTTTT(G/T)TTTTT intron-variant, upstream-variant-2KB
rs113408828 -- 10,929,024(+) TGGGC(C/G)CGCGC upstream-variant-2KB, reference, synonymous-codon
rs1135488 -- 10,930,130(+) aggca(A/G)gagaa upstream-variant-2KB, utr-variant-3-prime
rs114814880 -- 10,928,318(+) CGTAT(C/G)GGGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TIMM29 Gene

Variant ID Type Subtype PubMed ID
nsv833749 CNV loss 17160897

Variation tolerance for TIMM29 Gene

Gene Damage Index Score: 0.91; 18.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM29 Gene

Disorders for TIMM29 Gene

Relevant External Links for TIMM29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM29

No disorders were found for TIMM29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM29 Gene

Publications for TIMM29 Gene

  1. Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. (PMID: 27554484) Kang Y. … Stojanovski D. (Elife 2016) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  4. TIM29 is a subunit of the human carrier translocase required for protein transport. (PMID: 27718247) Callegari S. … Rehling P. (FEBS Lett. 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TIMM29 Gene

Sources for TIMM29 Gene

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