TIMM23B Gene
protein-coding GIFtS: 31
GCID: GC10P051371 (predicted)
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translocase of inner mitochondrial membrane 23 homolog B...
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Aliases
for TIMM23B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Translocase Of Inner Mitochondrial Membrane 23 Homolog B (Yeast)1 2 | | BA592B15.71 | | TIMM232 | | Putative Mitochondrial Import Inner Membrane Translocase Subunit Tim23B2 |
Export aliases for TIMM23B gene to outside databasesPrevious GC identifers: GC10U900492 GC10P051042 |
Summaries
for TIMM23B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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UniProtKB/Swiss-Prot: TI23B_HUMAN, Q5SRD1Function: May participate in the translocation of transit peptide-containing proteins across the mitochondrial innermembrane. the PAM complex (By similarity)
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Genomic Views
for TIMM23B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TIMM23B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIMM23B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM23B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.23TIMM23B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P051371: view genomic region
(about GC identifiers)
Start:
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51,371,379 bp from pter |
End:
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51,734,610 bp from pter |
Size:
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363,232 bases |
Orientation:
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plus strand |
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Proteins
for TIMM23B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: TI23B_HUMAN, Q5SRD1 (See
protein sequence)Recommended Name: Putative mitochondrial import inner membrane translocase subunit Tim23B Size: 257 amino acids; 28048 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Caution: Could be the product of a pseudogene
Secondary accessions: Q5SRD2Explore the universe of human proteins at neXtProt for TIMM23B: NX_Q5SRD1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SRD1
TIMM23B Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000363211 ENSP00000363210 ENSP00000389331 ENSP00000409439
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005575 | cellular_component |
ND | -- | | GO:0005744 | mitochondrial inner membrane presequence translocase complex |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TIMM23B for ontologies About GeneDecksing
TIMM23B Antibody Products:
Assay Products for TIMM23B: |
Protein
Domains /
Families
for TIMM23B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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TIMM23B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5SRD1ProtoNet protein and cluster: Q5SRD1 1 Blocks protein family: IPB003397 Mitochondrial import inner membrane translocase
UniProtKB/Swiss-Prot: TI23B_HUMAN, Q5SRD1Similarity: Belongs to the Tim17/Tim22/Tim23 family |
Function
for TIMM23B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: TI23B_HUMAN, Q5SRD1Function: May participate in the translocation of transit peptide-containing proteins across the mitochondrial innermembrane. the PAM complex (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003674 | molecular_function |
ND | -- | | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity |
IEA | -- |
TIMM23B for ontologies About GeneDecksing
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Pathways & Interactions
for TIMM23B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIMM23B
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006886 | intracellular protein transport |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
TIMM23B for ontologies About GeneDecksing
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Drugs & Compounds
for TIMM23B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for TIMM23B
Search CenterWatch for drugs/clinical trials and news about TIMM23B / TI23B 
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Transcripts
for TIMM23B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478381 ENST00000462932(uc001jin.3) ENST00000374098 ENST00000483296
ENST00000374097 ENST00000451577 ENST00000429265(uc010qha.2 uc010qhb.2 uc010qhc.2 uc001jiv.1)
GeneLoc Exon Structure
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Expression
for TIMM23B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIMM23B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TIMM23B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIMM23B
SABiosciences Custom PCR Arrays for TIMM23B
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TIMM23B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM23B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM23B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23B |
Orthologs
for TIMM23B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for TIMM23B gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for TIMM23B (if available)
TreeFam Gene Tree for TIMM23B (if available) |
Paralogs
for TIMM23B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TIMM23B gene
- TIMM232
1 SIMAP similar gene for TIMM23B using alignment to 5 protein entries: TI23B_HUMAN (see all proteins):TIMM23
TIMM23B for paralogs About GeneDecksing
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Genomic Variants
for TIMM23B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for TIMM23B (51371379 - 51621379 bp, first 250kb of TIMM23B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIMM23B: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TIMM23B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for TIMM23B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for TIMM23B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TIMM23B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. (PubMed id 15044455)1 Guo Y.... Alnemri E.S. (2004)
- Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. (PubMed id 12437925)1 Yamamoto H....Endo T. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TIMM23B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TIMM23B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing TIMM23B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIMM23B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TIMM23B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TIMM23B gene:
Search GeneIP for patents involving TIMM23B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIMM23B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMM23B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM23B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM23B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM23B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM23B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM23B |
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 | | | TIMM23B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23B |
|  |  |  | | | | Search ThermoFisher Antibodies for TIMM23B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIMM23B |
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