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Aliases for TIMM23B Gene

Aliases for TIMM23B Gene

  • Translocase Of Inner Mitochondrial Membrane 23 Homolog B 2 3 5
  • Putative Mitochondrial Import Inner Membrane Translocase Subunit Tim23B 3
  • Translocase Of Inner Mitochondrial Membrane 23 Homolog B (Yeast) 2
  • BA592B15.7 3
  • TIMM23 3

External Ids for TIMM23B Gene

Previous GeneCards Identifiers for TIMM23B Gene

  • GC10U900492
  • GC10P051042
  • GC10P051371
  • GC10P051729

Summaries for TIMM23B Gene

GeneCards Summary for TIMM23B Gene

TIMM23B (Translocase Of Inner Mitochondrial Membrane 23 Homolog B) is a Protein Coding gene. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM23.

UniProtKB/Swiss-Prot for TIMM23B Gene

  • May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM23B Gene

Genomics for TIMM23B Gene

Genomic Location for TIMM23B Gene

Chromosome:
10
Start:
49,942,033 bp from pter
End:
49,988,839 bp from pter
Size:
46,807 bases
Orientation:
Plus strand

Genomic View for TIMM23B Gene

Genes around TIMM23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM23B Gene

No data available for Regulatory Elements for TIMM23B Gene

Proteins for TIMM23B Gene

  • Protein details for TIMM23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SRD1-TI23B_HUMAN
    Recommended name:
    Putative mitochondrial import inner membrane translocase subunit Tim23B
    Protein Accession:
    Q5SRD1
    Secondary Accessions:
    • Q5SRD2

    Protein attributes for TIMM23B Gene

    Size:
    257 amino acids
    Molecular mass:
    28048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIMM23B Gene

Post-translational modifications for TIMM23B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM23B Gene

No data available for DME Specific Peptides for TIMM23B Gene

Domains & Families for TIMM23B Gene

Protein Domains for TIMM23B Gene

Suggested Antigen Peptide Sequences for TIMM23B Gene

Graphical View of Domain Structure for InterPro Entry

Q5SRD1

UniProtKB/Swiss-Prot:

TI23B_HUMAN :
  • Belongs to the Tim17/Tim22/Tim23 family.
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM23B: view

No data available for Gene Families for TIMM23B Gene

Function for TIMM23B Gene

Molecular function for TIMM23B Gene

UniProtKB/Swiss-Prot Function:
May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).

Gene Ontology (GO) - Molecular Function for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0015266 protein channel activity IBA --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TIMM23B: view

Phenotypes for TIMM23B Gene

GenomeRNAi human phenotypes for TIMM23B:
genes like me logo Genes that share phenotypes with TIMM23B: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM23B Gene

Localization for TIMM23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM23B Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM23B Gene COMPARTMENTS Subcellular localization image for TIMM23B gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005744 mitochondrial inner membrane presequence translocase complex IBA --
GO:0031305 integral component of mitochondrial inner membrane IBA --
genes like me logo Genes that share ontologies with TIMM23B: view

Pathways & Interactions for TIMM23B Gene

SuperPathways for TIMM23B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030150 protein import into mitochondrial matrix IBA --
genes like me logo Genes that share ontologies with TIMM23B: view

No data available for Pathways by source and SIGNOR curated interactions for TIMM23B Gene

Drugs & Compounds for TIMM23B Gene

No Compound Related Data Available

Transcripts for TIMM23B Gene

mRNA/cDNA for TIMM23B Gene

(6) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM23B Gene

No ASD Table

Relevant External Links for TIMM23B Gene

GeneLoc Exon Structure for
TIMM23B
ECgene alternative splicing isoforms for
TIMM23B

Expression for TIMM23B Gene

mRNA expression in normal human tissues for TIMM23B Gene

Protein differential expression in normal tissues from HIPED for TIMM23B Gene

This gene is overexpressed in Nasal epithelium (35.8), Bone (16.8), Pancreas (9.2), and Lung (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM23B Gene



Protein tissue co-expression partners for TIMM23B Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMM23B Gene:

TIMM23B
genes like me logo Genes that share expression patterns with TIMM23B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIMM23B Gene

Orthologs for TIMM23B Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM23B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM23B 34
  • 97.87 (n)
  • 96.28 (a)
TIMM23 35
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TIMM23 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm10273 35
  • 79 (a)
ManyToMany
Timm23 35
  • 79 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100535463 34
  • 72.11 (n)
  • 83.01 (a)
timm23 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG40042 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea timm-23 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5979 35
  • 23 (a)
OneToMany
Species where no ortholog for TIMM23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TIMM23B Gene

ENSEMBL:
Gene Tree for TIMM23B (if available)
TreeFam:
Gene Tree for TIMM23B (if available)

Paralogs for TIMM23B Gene

Paralogs for TIMM23B Gene

(11) SIMAP similar genes for TIMM23B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIMM23B: view

Variants for TIMM23B Gene

Sequence variations from dbSNP and Humsavar for TIMM23B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3203016 -- 49,968,965(+) TTGTG(A/G)TGCAT intron-variant
rs7098724 -- 49,967,063(+) tacag(G/T)cacat intron-variant
rs7896643 -- 49,970,653(+) ccgtc(C/T)gggag intron-variant, downstream-variant-500B
rs2338086 -- 49,965,544(-) TCTCA(C/T)TTCAT intron-variant
rs1061905 -- 49,968,994(+) CATTA(A/C)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM23B Gene

Variant ID Type Subtype PubMed ID
esv26750 CNV loss 19812545
nsv1143639 CNV deletion 24896259
nsv8655 CNV loss 18304495
nsv947999 CNV duplication 23825009

Relevant External Links for TIMM23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TIMM23B Gene

Disorders for TIMM23B Gene

Relevant External Links for TIMM23B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM23B

No disorders were found for TIMM23B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM23B Gene

Publications for TIMM23B Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 65
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 65
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 65

Products for TIMM23B Gene

Sources for TIMM23B Gene

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