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TIMM23 Gene

protein-coding   GIFtS: 50
GCID: GC10M051591

Translocase Of Inner Mitochondrial Membrane 23 Homolog (Yeast)

  See TIMM23-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Translocase Of Inner Mitochondrial Membrane 23 Homolog (Yeast)1 2
TIM232 3
Mitochondrial Import Inner Membrane Translocase Subunit Tim232

External Ids:    HGNC: 173121   Entrez Gene: 1002879322   Ensembl: ENSG000001382977   OMIM: 6050345   UniProtKB: O149253   
ORGUL members:         

Export aliases for TIMM23 gene to outside databases

Previous GC identifers: GC10M050145 GC10M050460 GC10M051484 GC10M050937 GC10M050936 GC10M051262 GC10M045699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIMM23 Gene:
The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates
the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one
protein-coding and others not protein-coding, have been found for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for TIMM23 Gene:
TIMM23 (translocase of inner mitochondrial membrane 23 homolog (yeast)) is a protein-coding gene. Diseases associated with TIMM23 include deafness dystonia syndrome. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM23B.

UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit
peptide-containing proteins across the mitochondrial inner membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIMM23 gene promoter:
         AhR   Pax-2   Pax-2a   YY1   FAC1   SRY   FOXC1   FOXJ2 (long isoform)   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM23 promoter sequence
   Search Chromatin IP Primers for TIMM23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMM23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.21-q11.23

TIMM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM23 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M051591:  view genomic region     (about GC identifiers)

Start:
51,592,080 bp from pter      End:
51,623,365 bp from pter
Size:
31,286 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim23  
Size: 209 amino acids; 21943 Da
Subunit: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50;
within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM
complex and with DNAJC15
Secondary accessions: Q53FF8 Q5T1E6 Q6P5S5

Explore the universe of human proteins at neXtProt for TIMM23: NX_O14925

Explore proteomics data for TIMM23 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIMM23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006318.1  
    ENSEMBL proteins: 
     ENSP00000408548   ENSP00000260867   ENSP00000363178   ENSP00000363177  
    Reactome Protein details: O14925

    TIMM23 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TIMM23

     
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    Search antibodies-online for proteins for TIMM23 

     
    Search antibodies-online for peptides for TIMM23

    TIMM23 Antibody Products:

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    antibodies-online antibodies for TIMM23 (7 products) 

    TIMM23 Assay Products:

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    Cloud-Clone Corp. ELISAs for TIMM23
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    antibodies-online kits for TIMM23 (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003397 Tim17/Tim22/Tim23/PMP24
     IPR005681 Tim23

    Graphical View of Domain Structure for InterPro Entry O14925

    ProtoNet protein and cluster: O14925

    1 Blocks protein domain: IPB003397 Mitochondrial import inner membrane translocase

    UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925
    Similarity: Belongs to the Tim17/Tim22/Tim23 family


    Find genes that share domains with TIMM23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM23_HUMAN, O14925
    Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit
    peptide-containing proteins across the mitochondrial inner membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15044455
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA--
         
    Find genes that share ontologies with TIMM23           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Timm23):
     behavior/neurological  integument  mortality/aging  normal  skeleton 

    Find genes that share phenotypes with TIMM23           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TIMM23

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIMM23:
    hsa-mir-125b-5p (MIRT046055), hsa-mir-484 (MIRT042029), hsa-mir-196a-5p (MIRT026070), hsa-let-7b-5p (MIRT032261)

    Block miRNA regulation of human, mouse, rat TIMM23 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TIMM23:
    hsa-miR-4314 hsa-miR-182* hsa-miR-659 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidTIMM23 3' UTR sequence
    Inhib. RNA
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIMM23

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIM23_HUMAN, O14925: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS14726512
    GO:0005744mitochondrial inner membrane presequence translocase complex IDA10339406
    GO:0005758mitochondrial intermembrane space IDA15044455
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TIMM23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with TIMM23           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways



    1 Reactome Pathway for TIMM23
        Mitochondrial protein import


        Pathway & Disease-focused RT2 Profiler PCR Array including TIMM23: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TIMM23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIMM23 (O149251, 2, 3 ENSP000002608674) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV83, ENSP000003524084I2D: score=1 STRING: ENSP00000352408
    BRF2Q9HAW03, ENSP000002206594I2D: score=1 STRING: ENSP00000220659
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    TIMM17BO608303, ENSP000003657664I2D: score=1 STRING: ENSP00000365766
    TIMM44O436153, ENSP000002705384I2D: score=1 STRING: ENSP00000270538
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with TIMM23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIMM23 (TIM23)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIMM23 gene: 
    NM_006327.3  

    Unigene Clusters for TIMM23:

    Translocase of inner mitochondrial membrane 23 homolog (yeast)
    Hs.499594  [show with all ESTs], Hs.524308  [show with all ESTs]
    Unigene Representative Sequences: AK098044, NR_073029
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444743 ENST00000260867(uc001jiu.3 uc010qhg.2) ENST00000485812
    ENST00000374065 ENST00000476778 ENST00000469116 ENST00000480051 ENST00000374064

    miRNA
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    Block miRNA regulation of human, mouse, rat TIMM23 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TIMM23:
    hsa-miR-4314 hsa-miR-182* hsa-miR-659 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidTIMM23 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMM23
      QuantiTect SYBR Green Assays in human, mouse, rat TIMM23
      QuantiFast Probe-based Assays in human, mouse, rat TIMM23

    Additional mRNA sequence: 

    AF030162.1 AK223331.1 AK295370.1 AK304883.1 AK316549.1 AY442341.1 BC062707.1 BC066951.1 
    NR_073029.1 NR_073030.1 U38436.1 

    Selected DOTS entries (see all 31):

    DT.97815151  DT.95117144  DT.100812327  DT.317811  DT.87016307  DT.91716330  DT.100037499  DT.40208029 
    DT.100812330  DT.95337836  DT.121281811  DT.95123524  DT.121281792  DT.95155980  DT.121281468  DT.121281553 
    DT.100774918  DT.121238862  DT.121281483  DT.121281544  DT.121281749  DT.121288972  DT.91757477  DT.91757485 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM23    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                  -           -               
    SP2:                                                  -                           
    SP3:                                            -     -           -               
    SP4:                          -                       -                           
    SP5:                                                                              


    ECgene alternative splicing isoforms for TIMM23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIMM23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTAGAAAA
    TIMM23 Expression
    About this image

    TIMM23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIMM23 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.499594 Hs.524308
        Pathway & Disease-focused RT2 Profiler PCR Array including TIMM23: 
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TIMM23 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm231 , 5 translocase of inner mitochondrial membrane 23 homolog more5
    translocase of inner mitochondrial membrane 231
    90.43(n)1
    97.13(a)1
      14 (19.40 cM)5
    536001  NM_016897.31  NP_058593.21 
     321801625 
    chicken
    (Gallus gallus)
    Aves TIMM231 translocase of inner mitochondrial membrane 23 homolog more 81.34(n)
    91.85(a)
      423616  XM_421501.4  XP_421501.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL343199.1(3842764-3867568)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia timm231 translocase of inner mitochondrial membrane 23 homolog 76.09(n)
    89.67(a)
      496463  NM_001011053.1  NP_001011053.1 
    zebrafish
    (Danio rerio)
    Actinopterygii timm231 translocase of inner mitochondrial membrane 23 homolog more 71.94(n)
    81.92(a)
      798429  NM_001105598.1  NP_001099068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG400421 CG40042 52.16(n)
    53.9(a)
      3355096  NM_001015387.3  NP_001015387.1 
    worm
    (Caenorhabditis elegans)
    Secernentea timm-236
    Protein F15D3.7 (F15D3.7) mRNA, complete cds
    21(a)
    1 → many
    I(11578641-11579612) WBGene00008857


    ENSEMBL Gene Tree for TIMM23 (if available)
    TreeFam Gene Tree for TIMM23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIMM23 gene
    TIMM23B2  
    1 SIMAP similar gene for TIMM23 using alignment to 4 protein entries:     TIM23_HUMAN (see all proteins):
    TIMM23B

    Find genes that share paralogs with TIMM23           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIMM23 (see all 330)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383991141,2
    --51591586(+) AGCATA/CCTAGT 3 -- ds50010--------
    rs1115835671,2
    C,F--51591770(+) CCAGCC/GTCAAC 3 -- ds50012Minor allele frequency- G:0.02MN CSA 142
    rs1474422221,2
    --51591889(+) CTGACC/GTCAGG 3 -- ds50010--------
    rs1826412391,2
    --51591940(+) GGCGTA/GAGCCA 3 -- ds50010--------
    rs118181731,2
    C,F,H--51591991(+) GAAGAT/AGTTGT 3 -- ds50016Minor allele frequency- A:0.04NS EA WA 536
    rs118176731,2
    C,F,H--51592012(+) GGGACA/CAAAAA 3 -- ds500113Minor allele frequency- C:0.06NS EA NA WA 1338
    rs1397680981,2
    --51592047(+) ACCCAA/GGTAGA 3 -- ds50010--------
    rs412740861,2
    C--51592181(+) GTGATA/GTAGTA 3 -- ut31 nc-transcript-variant0--------
    rs1876445791,2
    --51592182(+) TGATAC/TAGTAC 3 -- nc-transcript-variantut310--------
    rs1486562341,2
    C--51592281(+) CAGAAC/GCATGG 6 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for TIMM23 (51592080 - 51623365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TIMM23 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508583CNV Loss20534489
    nsv895383CNV Loss21882294
    nsv521269CNV Gain19592680
    nsv470936CNV Gain18288195
    dgv702n71CNV Gain21882294
    nsv518071CNV Gain19592680
    nsv895388CNV Gain21882294
    nsv467192CNV Gain19166990
    nsv428232CNV Gain+Loss18775914
    dgv275e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMM23
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605034    OMIM disorders: --

    1 disease for TIMM23:    
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    deafness dystonia syndrome

    1 disease from the University of Copenhagen DISEASES database for TIMM23:
    Deafness dystonia syndrome

    Find genes that share disorders with TIMM23           About GenesLikeMe

    Genetic Association Database (GAD): TIMM23

    Export disorders for TIMM23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIMM23 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TIMM23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PubMed id 10339406)1, 2, 3 Bauer M.F.... Hofmann S. (J. Mol. Biol. 1999)
    2. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. (PubMed id 23263864)1, 2 Schusdziarra C....Hell K. (Hum. Mol. Genet. 2013)
    3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. (PubMed id 15044455)1, 2 Guo Y.... Alnemri E.S. (J. Biol. Chem. 2004)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Interaction of presequence peptides with human translocase of inner membrane of mitochondria Tim23. (PubMed id 23811401)1 Zhang Y....Li S.J. (Biochem. Biophys. Res. Commun. 2013)
    9. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PubMed id 23260140)1 Mick D.U.... Rehling P. (Cell 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100287932 HGNC: 17312 Ensembl:ENSG00000138297 euGenes: HUgn100287932 ECgene: TIMM23
    H-InvDB: TIMM23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIMM23 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM23 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIMM23 gene:
    Search GeneIP for patents involving TIMM23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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