TIMM23 Gene
protein-coding GIFtS: 47
GCID: GC10M051591
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translocase of inner mitochondrial membrane 23 homolog (yeast)
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Aliases
for TIMM23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocase Of Inner Mitochondrial Membrane 23 Homolog (Yeast)1 2 | | TIM231 2 3 | | Mitochondrial Import Inner Membrane Translocase Subunit Tim232 |
Export aliases for TIMM23 gene to outside databasesPrevious GC identifers: GC10M050145 GC10M050460 GC10M051484 GC10M050937 GC10M050936 GC10M051262 GC10M045699 |
Summaries
for TIMM23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TIMM23:
The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates thetransport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-codingand others not protein-coding, have been found for this gene. (provided by RefSeq, Jul 2012)
UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transitpeptide-containing proteins across the mitochondrial inner membrane
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Genomic Views
for TIMM23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TIMM23 gene promoter:
AhR Pax-2 Pax-2a YY1 FAC1 SRY FOXC1 FOXJ2 (long isoform) Cart-1 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIMM23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.21-q11.23TIMM23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M051591: view genomic region
(about GC identifiers)
Start:
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51,592,080 bp from pter |
End:
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51,623,365 bp from pter |
Size:
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31,286 bases |
Orientation:
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minus strand |
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Proteins
for TIMM23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925 (See
protein sequence)Recommended Name: Mitochondrial import inner membrane translocase subunit Tim23 Size: 209 amino acids; 21943 Da
Subunit: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. Interactsdirectly with TIMM50. The complex interacts with the TIMM44 component of the PAM complex
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q53FF8 Q5T1E6 Q6P5S5Explore the universe of human proteins at neXtProt for TIMM23: NX_O14925
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14925
TIMM23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006318.1
ENSEMBL proteins: ENSP00000260867 ENSP00000408548 ENSP00000363178 ENSP00000363177 Reactome Protein details: O14925
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TIMM23 for ontologies About GeneDecksing
TIMM23 Antibody Products:
Assay Products for TIMM23: |
Protein
Domains /
Families
for TIMM23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIMM23 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14925ProtoNet protein and cluster: O14925 1 Blocks protein family: IPB003397 Mitochondrial import inner membrane translocase
UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925Similarity: Belongs to the Tim17/Tim22/Tim23 family |
Function
for TIMM23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transitpeptide-containing proteins across the mitochondrial inner membrane
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | 15044455 | | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity |
IEA | -- |
TIMM23 for ontologies About GeneDecksing
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Timm23):
TIMM23 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TIMM23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for TIMM23
TIMM23 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMM23
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for TIMM23 (O149252, 3 ENSP000002608674) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
TIMM23 for ontologies About GeneDecksing
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Drugs & Compounds
for TIMM23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TIMM23
Search CenterWatch for drugs/clinical trials and news about TIMM23 / TIM23
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Transcripts
for TIMM23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TIMM23 gene: NM_006327.3 Unigene Clusters for TIMM23: Translocase of inner mitochondrial membrane 23 homolog (yeast) Hs.499594 [show with all ESTs], Hs.524308 [show with all ESTs]Unigene Representative Sequences: AK098044, NR_0730298 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000260867(uc001jiu.3 uc010qhg.2) ENST00000444743 ENST00000485812
ENST00000374065 ENST00000476778 ENST00000469116 ENST00000480051 ENST00000374064
Additional cDNA sequence: AF030162.1 AK223331.1 AK295370.1 AK304883.1 AK316549.1 AY442341.1 BC062707.1 BC066951.1 NR_073029.1 NR_073030.1 U38436.1 24/31 DOTS entries (see all 31): DT.97815151 DT.95117144 DT.100812327 DT.317811 DT.87016307 DT.91716330 DT.100037499 DT.40208029 DT.100812330 DT.95337836 DT.121281811 DT.95123524 DT.121281792 DT.95155980 DT.121281468 DT.121281553 DT.91821103 DT.100774918 DT.121238862 DT.121281483 DT.121281544 DT.121281728 DT.121281749 DT.121288972
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM23 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
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| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TIMM23
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Expression
for TIMM23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIMM23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTAGAAAA
About this image
See TIMM23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIMM23
SOURCE GeneReport for Unigene clusters: Hs.499594 Hs.524308
SABiosciences Expression via Pathway-Focused PCR Array including TIMM23:
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM23 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23 |
Orthologs
for TIMM23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TIMM23 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for TIMM23 (if available)
TreeFam Gene Tree for TIMM23 (if available) |
Paralogs
for TIMM23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TIMM23 gene
- TIMM23B2
1 SIMAP similar gene for TIMM23 using alignment to 4 protein entries: TIM23_HUMAN (see all proteins):TIMM23B
TIMM23 for paralogs About GeneDecksing
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Genomic Variants
for TIMM23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TIMM23 (51592080 - 51623365 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TIMM23
2 CNVs: 85270 3800 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM23 |
|
Disorders
/ Diseases
for TIMM23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TIMM23 for disorders About MalaCards
TIMM23 for disorders About GeneDecksing
OMIM gene information: 605034
OMIM disorders: --
Export disorders for TIMM23 gene to outside databases
|
Publications
for TIMM23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIMM23 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with TIMM23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PubMed id 10339406)1, 2, 3 Bauer M.F.... Hofmann S. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. (PubMed id 15044455)1, 2 Guo Y.... Alnemri E.S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The structural characteristics of human preprotein tra nslocase of the inner mitochondrial membrane Tim23: implications for its physiol ogical activities. (PubMed id 22306744)1 Zhang Y....Li S.J. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for TIMM23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TIMM23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIMM23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIMM23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TIMM23 gene:
Search GeneIP for patents involving TIMM23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIMM23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMM23 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM23 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM23 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM23 |
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 |  |  |  | |
| | | | Search Tocris compounds for TIMM23 |
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 | | | TIMM23 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23 |
|  |  |  | | | | Search ThermoFisher Antibodies for TIMM23 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIMM23 |
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