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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMM23 Gene

protein-coding   GIFtS: 48
GCID: GC10M051591

Translocase Of Inner Mitochondrial Membrane 23 Homolog (Yeast)

  Search for TIMM23
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocase Of Inner Mitochondrial Membrane 23 Homolog (Yeast)1 2
TIM232 3
Mitochondrial Import Inner Membrane Translocase Subunit Tim232

External Ids:    HGNC: 173121   Entrez Gene: 1002879322   Ensembl: ENSG000001382977   OMIM: 6050345   UniProtKB: O149253   

Export aliases for TIMM23 gene to outside databases

Previous GC identifers: GC10M050145 GC10M050460 GC10M051484 GC10M050937 GC10M050936 GC10M051262 GC10M045699


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIMM23 Gene:
The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates
the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one
protein-coding and others not protein-coding, have been found for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for TIMM23 Gene: 
TIMM23 (translocase of inner mitochondrial membrane 23 homolog (yeast)) is a protein-coding gene. Among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM23B.

UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit
peptide-containing proteins across the mitochondrial inner membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMM23 gene promoter:
         AhR   Pax-2   Pax-2a   YY1   FAC1   SRY   FOXC1   FOXJ2 (long isoform)   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM23 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMM23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.21-q11.23

TIMM23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM23 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M051591:  view genomic region     (about GC identifiers)

Start:
51,592,080 bp from pter      End:
51,623,365 bp from pter
Size:
31,286 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim23  
Size: 209 amino acids; 21943 Da
Subunit: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
Interacts directly with TIMM50. The complex interacts with the TIMM44 component of the PAM complex
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q53FF8 Q5T1E6 Q6P5S5

Explore the universe of human proteins at neXtProt for TIMM23: NX_O14925

Explore proteomics data for TIMM23 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14925

  • TIMM23 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMM23 Protein Expression
    REFSEQ proteins: NP_006318.1  
    ENSEMBL proteins: 
     ENSP00000408548   ENSP00000260867   ENSP00000363178   ENSP00000363177  
    Reactome Protein details: O14925
    Human Recombinant Protein Products for TIMM23: 
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    OriGene Protein Over-expression Lysate for TIMM23
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIMM23 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS14726512
    GO:0005744mitochondrial inner membrane presequence translocase complex IDA10339406
    GO:0005758mitochondrial intermembrane space IDA15044455
    GO:0016021integral to membrane ----

    TIMM23 for ontologies           About GeneDecksing



    TIMM23 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TIMM23 

    Assay Products for TIMM23: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TIMM23 
    Cloud-Clone Corp. CLIAs for TIMM23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003397 Tim17/Tim22/Tim23/PMP24
     IPR005681 Tim23

    Graphical View of Domain Structure for InterPro Entry O14925

    ProtoNet protein and cluster: O14925

    1 Blocks protein domain: IPB003397 Mitochondrial import inner membrane translocase

    UniProtKB/Swiss-Prot: TIM23_HUMAN, O14925
    Similarity: Belongs to the Tim17/Tim22/Tim23 family


    TIMM23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM23_HUMAN, O14925
    Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit
    peptide-containing proteins across the mitochondrial inner membrane

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15044455
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA--
         
    TIMM23 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Timm23):
     behavior/neurological  integument  mortality/aging  normal  skeleton 

    TIMM23 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMM23 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMM23

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMM23 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMM23 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM23
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM23:
    hsa-miR-4314 hsa-miR-182* hsa-miR-659 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidTIMM23 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Sirion Biotech Customized adenovirus for overexpression of TIMM23

    Clone
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    OriGene clones in human, mouse for TIMM23 (see all 6)
    OriGene ORF clones in mouse, rat for TIMM23
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM23
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIMM23
    Sirion Biotech Customized lentivirus for stable overexpression of TIMM23 
                         Customized lentivirus expression plasmids for stable overexpression of TIMM23 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIMM23 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for TIMM23
        Mitochondrial Protein Import
    Metabolism of proteins



    TIMM23 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMM23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for TIMM23 (O149251, 2, 3 ENSP000002608674) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV83, ENSP000003524084I2D: score=1 STRING: ENSP00000352408
    BRF2Q9HAW03, ENSP000002206594I2D: score=1 STRING: ENSP00000220659
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    TIMM17BO608303, ENSP000003657664I2D: score=1 STRING: ENSP00000365766
    TIMM44O436153, ENSP000002705384I2D: score=1 STRING: ENSP00000270538
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--

    TIMM23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMM23 (TIM23)

    Search CenterWatch for drugs/clinical trials and news about TIMM23 / TIM23

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMM23 gene: 
    NM_006327.3  

    Unigene Clusters for TIMM23:

    Translocase of inner mitochondrial membrane 23 homolog (yeast)
    Hs.499594  [show with all ESTs], Hs.524308  [show with all ESTs]
    Unigene Representative Sequences: AK098044, NR_073029
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444743 ENST00000260867(uc001jiu.3 uc010qhg.2) ENST00000485812
    ENST00000374065 ENST00000476778 ENST00000469116 ENST00000480051 ENST00000374064

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM23:
    hsa-miR-4314 hsa-miR-182* hsa-miR-659 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidTIMM23 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM23
    Clone
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    OriGene ORF clones in mouse, rat for TIMM23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TIMM23
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM23
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIMM23
    Sirion Biotech Customized lentivirus for stable overexpression of TIMM23 
                         Customized lentivirus expression plasmids for stable overexpression of TIMM23 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM23

    Additional mRNA sequence: 

    AF030162.1 AK223331.1 AK295370.1 AK304883.1 AK316549.1 AY442341.1 BC062707.1 BC066951.1 
    NR_073029.1 NR_073030.1 U38436.1 

    24/31 DOTS entries (see all 31):

    DT.97815151  DT.95117144  DT.100812327  DT.317811  DT.87016307  DT.91716330  DT.100037499  DT.40208029 
    DT.100812330  DT.95337836  DT.121281811  DT.95123524  DT.121281792  DT.95155980  DT.121281468  DT.121281553 
    DT.100774918  DT.121238862  DT.121281483  DT.121281544  DT.121281749  DT.121288972  DT.91757477  DT.91757485 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM23    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                  -           -               
    SP2:                                                  -                           
    SP3:                                            -     -           -               
    SP4:                          -                       -                           
    SP5:                                                                              


    ECgene alternative splicing isoforms for TIMM23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMM23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTAGAAAA
    TIMM23 Expression
    About this image


    See TIMM23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMM23

    SOURCE GeneReport for Unigene clusters: Hs.499594 Hs.524308
        SABiosciences Expression via Pathway-Focused PCR Array including TIMM23: 
              Mitochondria in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TIMM23 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm231 , 5 translocase of inner mitochondrial membrane 23 homolog more5
    translocase of inner mitochondrial membrane 231
    90.43(n)1
    97.13(a)1
      14 (19.40 cM)5
    536001  NM_016897.31  NP_058593.21 
     321801625 
    chicken
    (Gallus gallus)
    Aves TIMM231 translocase of inner mitochondrial membrane 23 homolog more 79.49(n)
    88.94(a)
      423616  XM_421501.3  XP_421501.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL343199.1(3842764-3867568)
    zebrafish
    (Danio rerio)
    Actinopterygii timm231 translocase of inner mitochondrial membrane 23 homolog more 70.53(n)
    79.47(a)
      798429  NM_001105598.1  NP_001099068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG400421 CG40042 52.16(n)
    53.9(a)
      3355096  NM_001015387.2  NP_001015387.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F15D3.76
    Protein F15D3.7
    22(a)
    1 → many
    I(11578639-11579612)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIM23(YNR017W)4 Essential component of the Translocase of the Inner more   --   14(662913-663581) 855751  NP_014414.1 


    ENSEMBL Gene Tree for TIMM23 (if available)
    TreeFam Gene Tree for TIMM23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMM23 gene
    TIMM23B2  
    1 SIMAP similar gene for TIMM23 using alignment to 4 protein entries:     TIM23_HUMAN (see all proteins):
    TIMM23B

    TIMM23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/330 SNPs in TIMM23 are shown (see all 330)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383991141,2
    --51591586(+) AGCATA/CCTAGT 3 -- ds50010--------
    rs1115835671,2
    C,F--51591770(+) CCAGCC/GTCAAC 3 -- ds50012Minor allele frequency- G:0.02MN CSA 142
    rs1474422221,2
    --51591889(+) CTGACC/GTCAGG 3 -- ds50010--------
    rs1826412391,2
    --51591940(+) GGCGTA/GAGCCA 3 -- ds50010--------
    rs118181731,2
    C,F,H--51591991(+) GAAGAT/AGTTGT 3 -- ds50016Minor allele frequency- A:0.04NS EA WA 536
    rs118176731,2
    C,F,H--51592012(+) GGGACA/CAAAAA 3 -- ds500113Minor allele frequency- C:0.06NS EA NA WA 1338
    rs1397680981,2
    --51592047(+) ACCCAA/GGTAGA 3 -- ds50010--------
    rs412740861,2
    C--51592181(+) GTGATA/GTAGTA 3 -- ut31 nc-transcript-variant0--------
    rs1876445791,2
    --51592182(+) TGATAC/TAGTAC 3 -- nc-transcript-variantut310--------
    rs1486562341,2
    C--51592281(+) CAGAAC/GCATGG 6 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for TIMM23 (51592080 - 51623365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for TIMM23 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508583CNV Loss20534489
    nsv895383CNV Loss21882294
    nsv521269CNV Gain19592680
    nsv470936CNV Gain18288195
    dgv702n71CNV Gain21882294
    nsv518071CNV Gain19592680
    nsv895388CNV Gain21882294
    nsv467192CNV Gain19166990
    nsv428232CNV Gain+Loss18775914
    dgv275e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMM23
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TIMM23 for disorders           About MalaCards
    OMIM gene information: 605034    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TIMM23:
    Deafness dystonia syndrome

    TIMM23 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIMM23

    Export disorders for TIMM23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMM23 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TIMM23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PubMed id 10339406)1, 2, 3 Bauer M.F.... Hofmann S. (1999)
    2. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. (PubMed id 15044455)1, 2 Guo Y.... Alnemri E.S. (2004)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. Methylation-controlled J-protein MCJ acts in the impor t of proteins into human mitochondria. (PubMed id 23263864)1 Schusdziarra C....Hell K. (2013)
    8. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PubMed id 23260140)1 Mick D.U.... Rehling P. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. The structural characteristics of human preprotein tra nslocase of the inner mitochondrial membrane Tim23: implications for its physiol ogical activities. (PubMed id 22306744)1 Zhang Y....Li S.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100287932 HGNC: 17312 Ensembl:ENSG00000138297 euGenes: HUgn100287932 ECgene: TIMM23
    H-InvDB: TIMM23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMM23 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM23 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMM23 gene:
    Search GeneIP for patents involving TIMM23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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