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Aliases for TIMM23 Gene

Aliases for TIMM23 Gene

  • Translocase Of Inner Mitochondrial Membrane 23 2 3
  • Translocase Of Inner Mitochondrial Membrane 23 Homolog (Yeast) 2 5
  • TIM23 3 4
  • Translocase Of Inner Mitochondrial Membrane 23 Homolog 3
  • Translocase Of The Inner Mitochondrial Membrane 3

External Ids for TIMM23 Gene

Previous GeneCards Identifiers for TIMM23 Gene

  • GC10M050145
  • GC10M050460
  • GC10M051484
  • GC10M050937
  • GC10M050936
  • GC10M051262
  • GC10M051591
  • GC10M045699

Summaries for TIMM23 Gene

Entrez Gene Summary for TIMM23 Gene

  • The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for TIMM23 Gene

TIMM23 (Translocase Of Inner Mitochondrial Membrane 23) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Transport to the Golgi and subsequent modification. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM23B.

UniProtKB/Swiss-Prot for TIMM23 Gene

  • Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM23 Gene

Genomics for TIMM23 Gene

Regulatory Elements for TIMM23 Gene

Enhancers for TIMM23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TIMM23 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIMM23 Gene

45,972,449 bp from pter
46,003,742 bp from pter
31,294 bases
Plus strand

Genomic View for TIMM23 Gene

Genes around TIMM23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM23 Gene

Proteins for TIMM23 Gene

  • Protein details for TIMM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim23
    Protein Accession:
    Secondary Accessions:
    • Q53FF8
    • Q5T1E6
    • Q6P5S5

    Protein attributes for TIMM23 Gene

    209 amino acids
    Molecular mass:
    21943 Da
    Quaternary structure:
    • Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.

neXtProt entry for TIMM23 Gene

Proteomics data for TIMM23 Gene at MOPED

Post-translational modifications for TIMM23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM23 Gene

Domains & Families for TIMM23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Tim17/Tim22/Tim23 family.
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM23: view

No data available for Gene Families for TIMM23 Gene

Function for TIMM23 Gene

Molecular function for TIMM23 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
genes like me logo Genes that share phenotypes with TIMM23: view

Animal Model Products

CRISPR Products

miRNA for TIMM23 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM23 Gene

Localization for TIMM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM23 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TIMM23 Gene COMPARTMENTS Subcellular localization image for TIMM23 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TIMM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with TIMM23: view

Pathways & Interactions for TIMM23 Gene

genes like me logo Genes that share pathways with TIMM23: view

Pathways by source for TIMM23 Gene

2 Reactome pathways for TIMM23 Gene

Interacting Proteins for TIMM23 Gene

Selected Interacting proteins: O14925-TIM23_HUMAN for TIMM23 Gene via MINT UniProtKB I2D

Gene Ontology (GO) - Biological Process for TIMM23 Gene


No data available for SIGNOR curated interactions for TIMM23 Gene

Drugs & Compounds for TIMM23 Gene

No Compound Related Data Available

Transcripts for TIMM23 Gene

mRNA/cDNA for TIMM23 Gene

(3) REFSEQ mRNAs :
(21) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIMM23 Gene

Translocase of inner mitochondrial membrane 23 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM23 Gene

No ASD Table

Relevant External Links for TIMM23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMM23 Gene

mRNA expression in normal human tissues for TIMM23 Gene

Protein differential expression in normal tissues from HIPED for TIMM23 Gene

This gene is overexpressed in Pancreas (44.6) and Lung (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIMM23 Gene

SOURCE GeneReport for Unigene cluster for TIMM23 Gene Hs.499594

genes like me logo Genes that share expression patterns with TIMM23: view

Protein tissue co-expression partners for TIMM23 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIMM23 Gene

Orthologs for TIMM23 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM23 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIMM23 35
  • 94.1 (n)
  • 98.09 (a)
(Canis familiaris)
Mammalia LOC486776 35
  • 94.58 (n)
  • 97.61 (a)
(Mus musculus)
Mammalia Timm23 35
  • 90.43 (n)
  • 97.13 (a)
Timm23 16
(Pan troglodytes)
Mammalia TIMM23 35
  • 99.84 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100362432 35
  • 89.15 (n)
  • 96.17 (a)
(Gallus gallus)
Aves TIMM23 35
  • 81.34 (n)
  • 91.85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia timm23 35
  • 76.09 (n)
  • 89.67 (a)
(Danio rerio)
Actinopterygii timm23 35
  • 71.94 (n)
  • 81.92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010210 35
  • 54.06 (n)
  • 53.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40042 35
  • 52.16 (n)
  • 53.9 (a)
Species with no ortholog for TIMM23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMM23 Gene

Gene Tree for TIMM23 (if available)
Gene Tree for TIMM23 (if available)

Paralogs for TIMM23 Gene

Paralogs for TIMM23 Gene

(1) SIMAP similar genes for TIMM23 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TIMM23: view

Variants for TIMM23 Gene

Sequence variations from dbSNP and Humsavar for TIMM23 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs4247660 -- 45,988,883(-) CAAGT(A/G)TATTA intron-variant
rs4354644 -- 45,985,772(-) CCTTG(C/T)CTAAC intron-variant
rs4356175 -- 45,985,182(-) CAAAA(C/T)TTTAG intron-variant
rs4370880 -- 45,985,020(-) TAATC(C/T)ATGTA intron-variant
rs4375397 -- 45,978,593(-) AGAGG(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM23 Gene

Variant ID Type Subtype PubMed ID
dgv273e1 CNV Complex 17122850
nsv428232 CNV Gain+Loss 18775914
dgv274e1 CNV Complex 17122850
nsv895383 CNV Loss 21882294
nsv508583 CNV Loss 20534489
dgv275e1 CNV Complex 17122850
nsv510992 CNV Complex 20534489
dgv702n71 CNV Gain 21882294
nsv467192 CNV Gain 19166990
nsv470936 CNV Gain 18288195
nsv521269 CNV Gain 19592680
nsv895388 CNV Gain 21882294
nsv518071 CNV Gain 19592680

Variation tolerance for TIMM23 Gene

Gene Damage Index Score: 0.17; 3.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TIMM23 Gene

Disorders for TIMM23 Gene

Relevant External Links for TIMM23

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIMM23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM23 Gene

Publications for TIMM23 Gene

  1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PMID: 10339406) Bauer M.F. … Hofmann S. (J. Mol. Biol. 1999) 2 3 4 67
  2. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PMID: 23260140) Mick D.U. … Rehling P. (Cell 2012) 2 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. (PMID: 25997101) Guarani V. … Harper J.W. (Elife 2015) 3

Products for TIMM23 Gene

Sources for TIMM23 Gene