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TIMM22 Gene

protein-coding   GIFtS: 46
GCID: GC17P000900

Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast)

(Previous name: testis-expressed sequence 4)
(Previous symbol: TEX4)
  Search for TIMM22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast)1 2
Testis-Expressed Sequence 41 2 3
TEX41 2 3
TIM222 3 5
Mitochondrial Import Inner Membrane Translocase Subunit Tim222
Putative Membrane Protein2

External Ids:    HGNC: 173171   Entrez Gene: 299282   Ensembl: ENSG000001773707   OMIM: 6072515   UniProtKB: Q9Y5843   

Export aliases for TIMM22 gene to outside databases

Previous GC identifers: GC17P000997 GC17P001158 GC17P000853 GC17P000885 GC17P000847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TIMM22 Gene:
TIMM22 (translocase of inner mitochondrial membrane 22 homolog (yeast)) is a protein-coding gene. GO annotations related to this gene include protein channel activity.

UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584
Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of
multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the
voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as
external driving force in 2 voltage-dependent steps (By similarity)

Gene Wiki entry for TIMM22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TIMM22 gene promoter:
         STAT1   STAT1beta   MIF-1   CUTL1   STAT1alpha   AREB6   STAT3   FOXO1a   ATF   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM22 promoter sequence
   Search Chromatin IP Primers for TIMM22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

TIMM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM22 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P000900:  view genomic region     (about GC identifiers)

Start:
900,357 bp from pter      End:
906,911 bp from pter
Size:
6,555 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim22  
Size: 194 amino acids; 20031 Da
Subunit: Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein
FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A
small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts
directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B
Secondary accessions: Q9NWI8

Explore the universe of human proteins at neXtProt for TIMM22: NX_Q9Y584

Explore proteomics data for TIMM22 at MOPED


See TIMM22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_037469.2  
ENSEMBL proteins: 
 ENSP00000320236  
Reactome Protein details: Q9Y584

TIMM22 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for TIMM22
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Novus Biologicals TIMM22 Protein
Novus Biologicals TIMM22 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for TIMM22 

TIMM22 Antibody Products:

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Novus Biologicals TIMM22 Antibodies
Abcam antibodies for TIMM22
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Search LSBio for Antibodies for TIMM22

TIMM22 Assay Products:

Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for TIMM22
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Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for TIMM22 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR003397 Tim17/Tim22/Tim23/PMP24

Graphical View of Domain Structure for InterPro Entry Q9Y584

ProtoNet protein and cluster: Q9Y584

1 Blocks protein domain: IPB003397 Mitochondrial import inner membrane translocase

UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584
Similarity: Belongs to the Tim17/Tim22/Tim23 family


Find genes that share domains with TIMM22           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TIM22_HUMAN, Q9Y584
Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of
multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the
voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as
external driving force in 2 voltage-dependent steps (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0015266protein channel activity TAS14726512
     
Find genes that share ontologies with TIMM22           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for TIMM22:
 Increased G1 DNA content  Synthetic lethal with Ras 

     1 MGI phenotypic allele for Timm22 (no phenotypes)

Find genes that share phenotypes with TIMM22           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIMM22
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIMM22

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMM22
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMM22

miRNA
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Block miRNA regulation of human, mouse, rat TIMM22 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate TIMM22:
hsa-miR-146b-3p hsa-miR-874 hsa-miR-1289 hsa-miR-3667-3p
SwitchGear 3'UTR luciferase reporter plasmidTIMM22 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TIMM22
Predesigned siRNA for gene silencing in human, mouse, rat TIMM22

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TIMM22

Clone
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OriGene clones in human, mouse for TIMM22 (see all 6)
OriGene ORF clones in mouse, rat for TIMM22
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TIMM22 (NM_013337)
Sino Biological Human cDNA Clone for TIMM22
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM22
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM22

Cell Line
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GenScript Custom overexpressing Cell Line Services for TIMM22
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM22


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TIM22_HUMAN, Q9Y584: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
plasma membrane2
chloroplast1
endoplasmic reticulum1
extracellular1
nucleus1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane TAS14726512
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TIMM22           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TIMM22 About    
See pathways by source

SuperPathContained pathways About
1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30
2Mitochondrial Protein Import
Mitochondrial Protein Import


Find genes that share SuperPaths with TIMM22           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for TIMM22
    Mitochondrial protein import


    Pathway & Disease-focused RT2 Profiler PCR Array including TIMM22: 
          Mitochondria in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for TIMM22

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TIMM22 (Q9Y5843 ENSP000003202364) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
InteractantInteraction Details
GeneCardExternal ID(s)
TIMM10P620723, ENSP000002572454I2D: score=2 STRING: ENSP00000257245
TIMM10BQ9Y5J63, ENSP000002546164I2D: score=1 STRING: ENSP00000254616
PDCD6O753403I2D: score=3 
TIMM9Q9Y5J73I2D: score=1 
TOMM20ENSP000003555664STRING: ENSP00000355566
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006626protein targeting to mitochondrion TAS--
GO:0044267cellular protein metabolic process TAS--
GO:0045039protein import into mitochondrial inner membrane TAS14726512

Find genes that share ontologies with TIMM22           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TIMM22 (TIM22)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TIMM22 gene: 
NM_013337.2  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000327158(uc002fsc.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat TIMM22 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate TIMM22:
hsa-miR-146b-3p hsa-miR-874 hsa-miR-1289 hsa-miR-3667-3p
SwitchGear 3'UTR luciferase reporter plasmidTIMM22 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TIMM22
Predesigned siRNA for gene silencing in human, mouse, rat TIMM22
Clone
Products:
     
OriGene clones in human, mouse for TIMM22 (see all 6)
OriGene ORF clones in mouse, rat for TIMM22
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TIMM22 (NM_013337)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM22
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM22
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TIMM22
OriGene qSTAR qPCR primer pairs in human, mouse for TIMM22
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMM22
  QuantiTect SYBR Green Assays in human, mouse, rat TIMM22
  QuantiFast Probe-based Assays in human, mouse, rat TIMM22

Selected AceView cDNA sequences (see all 183):

BF447671 BM849408 BM762331 BU501713 AW247977 BE219311 AA960906 AA242762 
BF196141 BF987769 AI572188 AI671157 BQ682441 BP381777 BM313598 BM722933 
CA446624 AA767469 BM849278 CK822028 CB177221 BE326318 AI351259 AI215906 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TIMM22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TIMM22 Expression
About this image

TIMM22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TIMM22 Protein Expression
    Pathway & Disease-focused RT2 Profiler PCR Array including TIMM22: 
          Mitochondria in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TIMM22
OriGene qSTAR qPCR primer pairs in human, mouse for TIMM22
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMM22
QuantiTect SYBR Green Assays in human, mouse, rat TIMM22
QuantiFast Probe-based Assays in human, mouse, rat TIMM22
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM22

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM22 gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Timm221 , 5 translocase of inner mitochondrial membrane 22 homolog more5
translocase of inner mitochondrial membrane 221
88.49(n)1
95.36(a)1
  11 (45.92 cM)5
563221  NM_019818.41  NP_062792.21 
 764069525 
chicken
(Gallus gallus)
Aves TIMM221 translocase of inner mitochondrial membrane 22 homolog more 78.01(n)
84.57(a)
  417594  XM_415839.4  XP_415839.4 
tropical clawed frog
(Xenopus tropicalis)
Amphibia timm221 translocase of inner mitochondrial membrane 22 homolog 76.03(n)
86.52(a)
  496870  NM_001011397.1  NP_001011397.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1005377791 mitochondrial import inner membrane translocase subunit more 71.6(n)
82.1(a)
  100537779  XM_003198715.2  XP_003198763.1 
fruit fly
(Drosophila melanogaster)
Insecta CG312291 CG31229 57.38(n)
52.53(a)
  318636  NM_169828.2  NP_732364.1 
worm
(Caenorhabditis elegans)
Secernentea CELE_C47G2.31 CELE_C47G2.3 50.47(n)
44.37(a)
  174722  NM_064011.3  NP_496412.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM22(YDL217C)4 Essential core component of the mitochondrial TIM22 more   --   4(68606-67983) 851309  NP_010064.1 


ENSEMBL Gene Tree for TIMM22 (if available)
TreeFam Gene Tree for TIMM22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TIMM22 (see all 242)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs752245481,2
C,F--898373(+) ACCATG/ACCCAG 1 -- us2k12Minor allele frequency- A:0.12NA EA 240
rs3336561,2
C,F,H--898395(-) TTGATC/TGGAAA 1 -- us2k112Minor allele frequency- T:0.02NS EA NA WA 1480
rs767181911,2
C--898473(+) AAAAAG/CTGTGC 1 -- us2k15Minor allele frequency- C:0.11CSA WA NA EA 361
rs1146897941,2
C,F--898520(+) TCATAC/TGAGGA 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1174021501,2
F--898750(+) GCCCTA/TACTGG 1 -- us2k11Minor allele frequency- T:0.02NA 120
rs1862498051,2
--898759(+) GGCCGA/GGCGCA 1 -- us2k10--------
rs778209911,2
C,F--898788(+) CCAAGC/TACTTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1909503671,2
--898809(+) GGTGGA/GTGGGT 1 -- us2k10--------
rs1832870731,2
--898960(+) AAACCC/TGGGAG 1 -- us2k10--------
rs1127854711,2
C--899007(+) CTCCAG/ACCTGG 1 -- us2k12Minor allele frequency- A:0.00CSA 2

HapMap Linkage Disequilibrium report for TIMM22 (900357 - 906911 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TIMM22 (see all 18):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422420CNV Duplication17116639
dgv3026n71CNV Loss21882294
dgv3025n71CNV Loss21882294
dgv3024n71CNV Loss21882294
nsv470566CNV Loss18288195
dgv3021n71CNV Loss21882294
nsv907472CNV Loss21882294
dgv3022n71CNV Loss21882294
dgv3023n71CNV Loss21882294
dgv172n21CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TIMM22
DNA2.0 Custom Variant and Variant Library Synthesis for TIMM22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607251    OMIM disorders: --


Find genes that share disorders with TIMM22           About GenesLikeMe

Genetic Association Database (GAD): TIMM22
Human Genome Epidemiology (HuGE) Navigator: TIMM22 (1 document)

Export disorders for TIMM22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TIMM22 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with TIMM22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)1, 2 Muehlenbein N.... Bauer M.F. (J. Biol. Chem. 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2 Bauer M.F.... Hofmann S. (FEBS Lett. 1999)
  6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  8. Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel. (PubMed id 11864609)1 Kovermann P....Pfanner N. (Mol. Cell 2002)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)1 Suzuki H....Hayashizaki Y. (Genome Res. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29928 HGNC: 17317 AceView: TIMM22 Ensembl:ENSG00000177370 euGenes: HUgn29928
ECgene: TIMM22 H-InvDB: TIMM22

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TIMM22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TIMM22 gene:
Search GeneIP for patents involving TIMM22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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