TIMM22 Gene
protein-coding GIFtS: 50
GCID: GC17P000900
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translocase of inner mitochondrial membrane 22 homolog (yeast)(Previous name: testis-expressed sequence 4 )
(Previous symbol: TEX4)
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Aliases
for TIMM22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast)1 2 | | Testis-Expressed Sequence 41 2 3 | | TEX41 2 3 | | TIM222 3 5 | | Mitochondrial Import Inner Membrane Translocase Subunit Tim222 | | Putative Membrane Protein2 |
Export aliases for TIMM22 gene to outside databasesPrevious GC identifers: GC17P000997 GC17P001158 GC17P000853 GC17P000885 GC17P000847 |
Summaries
for TIMM22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-passtransmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes thevoltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as externaldriving force in 2 voltage-dependent steps (By similarity)
Gene Wiki entry for TIMM22
|
Genomic Views
for TIMM22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TIMM22 gene promoter:
STAT1 STAT1beta MIF-1 CUTL1 STAT1alpha AREB6 STAT3 FOXO1a ATF FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIMM22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13TIMM22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P000900: view genomic region
(about GC identifiers)
Start:
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900,357 bp from pter |
End:
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905,407 bp from pter |
Size:
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5,051 bases |
Orientation:
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plus strand |
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Proteins
for TIMM22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584 (See
protein sequence)Recommended Name: Mitochondrial import inner membrane translocase subunit Tim22 Size: 194 amino acids; 20031 Da
Subunit: Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral proteinFXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A smallfraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly withTIMM9, TIMM10/TIM10A and FXC1/TIM10B
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q9NWI8Explore the universe of human proteins at neXtProt for TIMM22: NX_Q9Y584
TIMM22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037469.2
ENSEMBL proteins: ENSP00000320236 Reactome Protein details: Q9Y584
Human Recombinant Protein Products for TIMM22:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TIMM22 for ontologies About GeneDecksing
TIMM22 Antibody Products:
Assay Products for TIMM22: |
Protein
Domains /
Families
for TIMM22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIMM22 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y584ProtoNet protein and cluster: Q9Y584 1 Blocks protein family: IPB003397 Mitochondrial import inner membrane translocase
UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584Similarity: Belongs to the Tim17/Tim22/Tim23 family |
Function
for TIMM22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TIM22_HUMAN, Q9Y584Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-passtransmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes thevoltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as externaldriving force in 2 voltage-dependent steps (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TIMM22 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for TIMM22:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM22
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TIMM22 (NM_013337) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIMM22 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM22 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM22 |
|
Pathways & Interactions
for TIMM22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for TIMM22
TIMM22 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIMM22
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/19 Interacting proteins for TIMM22 (Q9Y5843 ENSP000003202364) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- | | GO:0045039 | protein import into mitochondrial inner membrane |
TAS | 14726512 |
TIMM22 for ontologies About GeneDecksing
|
Drugs & Compounds
for TIMM22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TIMM22
Search CenterWatch for drugs/clinical trials and news about TIMM22 / TIM22
|
Transcripts
for TIMM22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TIMM22 gene: NM_013337.2 Unigene Cluster for TIMM22: Translocase of inner mitochondrial membrane 22 homolog (yeast) Hs.592108 [show with all ESTs]Unigene Representative Sequence: NM_0133371 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000327158(uc002fsc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM22
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TIMM22 (NM_013337) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIMM22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM22 |
Additional cDNA sequence: AF155330.1 AK000830.1 AK225453.1 BC002324.2 5 DOTS entries: DT.415240 DT.120991530 DT.100781881 DT.102836961 DT.120991525 24/183 AceView cDNA sequences (see all 183): AI351259 AW247977 AA767469 CK822028 CR607232 BF447671 BX092484 BM722933 CB115245 BM762331 AA923711 BU501713 BQ070620 BQ925032 AI215906 BQ676268 BM849408 AI671157 BM849278 BE326318 BF196141 CA446624 BQ682441 AA242762
GeneLoc Exon Structure
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Expression
for TIMM22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIMM22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TIMM22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIMM22
SOURCE GeneReport for Unigene cluster: Hs.592108
SABiosciences Expression via Pathway-Focused PCR Array including TIMM22:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM22 |
Orthologs
for TIMM22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TIMM22 gene from 7/27 species (see all 27) About this table
ENSEMBL Gene Tree for TIMM22 (if available)
TreeFam Gene Tree for TIMM22 (if available) |
Paralogs
for TIMM22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TIMM22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TIMM22 (900357 - 905407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TIMM22
4 CNVs: 8833 3136 4021 30018 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM22 |
|
Disorders
/ Diseases
for TIMM22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TIMM22 for disorders About GeneDecksing
OMIM gene information: 607251
OMIM disorders: --
3  diseases for TIMM22: About MalaCardstwinning blindness malaria
Human Genome Epidemiology (HuGE) Navigator: TIMM22 (1 document)
Export disorders for TIMM22 gene to outside databases
|
Publications
for TIMM22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIMM22 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TIMM22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)1, 2 Muhlenbein N....Bauer M.F. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2 Bauer M.F.... Hofmann S. (1999)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel. (PubMed id 11864609)1 Kovermann P....Pfanner N. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)1 Suzuki H....Hayashizaki Y. (2001)
|
External Searches for TIMM22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TIMM22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIMM22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIMM22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TIMM22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TIMM22 gene:
Search GeneIP for patents involving TIMM22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIMM22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TIMM22 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM22 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM22 | | | OriGene Protein Over-expression Lysate for TIMM22 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TIMM22 | | OriGene 3'-UTR Clone for TIMM22 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMM22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM22 |
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 |  |  |  | |
| | | | Search Tocris compounds for TIMM22 |
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 | | | TIMM22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM22 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TIMM22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM22 |
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