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Aliases for TIMM22 Gene

Aliases for TIMM22 Gene

  • Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast) 2 3 5
  • Testis-Expressed Sequence 4 2 3 4
  • TIM22 3 4
  • TEX4 3 4
  • Putative Membrane Protein 3

External Ids for TIMM22 Gene

Previous HGNC Symbols for TIMM22 Gene

  • TEX4

Previous GeneCards Identifiers for TIMM22 Gene

  • GC17P001158
  • GC17P000853
  • GC17P000885
  • GC17P000847
  • GC17P000900

Summaries for TIMM22 Gene

GeneCards Summary for TIMM22 Gene

TIMM22 (Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. GO annotations related to this gene include protein channel activity.

UniProtKB/Swiss-Prot for TIMM22 Gene

  • Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Gene Wiki entry for TIMM22 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM22 Gene

Genomics for TIMM22 Gene

Regulatory Elements for TIMM22 Gene

Enhancers for TIMM22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TIMM22 on UCSC Golden Path with GeneCards custom track

Promoters for TIMM22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIMM22 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIMM22 Gene

Chromosome:
17
Start:
997,117 bp from pter
End:
1,003,671 bp from pter
Size:
6,555 bases
Orientation:
Plus strand

Genomic View for TIMM22 Gene

Genes around TIMM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM22 Gene

Proteins for TIMM22 Gene

  • Protein details for TIMM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y584-TIM22_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim22
    Protein Accession:
    Q9Y584
    Secondary Accessions:
    • Q9NWI8

    Protein attributes for TIMM22 Gene

    Size:
    194 amino acids
    Molecular mass:
    20031 Da
    Quaternary structure:
    • Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

neXtProt entry for TIMM22 Gene

Proteomics data for TIMM22 Gene at MOPED

Post-translational modifications for TIMM22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM22 Gene

Domains & Families for TIMM22 Gene

Protein Domains for TIMM22 Gene

Suggested Antigen Peptide Sequences for TIMM22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y584

UniProtKB/Swiss-Prot:

TIM22_HUMAN :
  • Belongs to the Tim17/Tim22/Tim23 family.
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM22: view

No data available for Gene Families for TIMM22 Gene

Function for TIMM22 Gene

Molecular function for TIMM22 Gene

UniProtKB/Swiss-Prot Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Gene Ontology (GO) - Molecular Function for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015266 protein channel activity TAS 14726512
genes like me logo Genes that share ontologies with TIMM22: view
genes like me logo Genes that share phenotypes with TIMM22: view

Animal Models for TIMM22 Gene

MGI Knock Outs for TIMM22:

Animal Model Products

  • Taconic Biosciences Mouse Models for TIMM22

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMM22 Gene

Localization for TIMM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM22 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM22 Gene COMPARTMENTS Subcellular localization image for TIMM22 gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS 14726512
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIMM22: view

Pathways & Interactions for TIMM22 Gene

genes like me logo Genes that share pathways with TIMM22: view

Pathways by source for TIMM22 Gene

2 Reactome pathways for TIMM22 Gene

Gene Ontology (GO) - Biological Process for TIMM22 Gene

None

No data available for SIGNOR curated interactions for TIMM22 Gene

Drugs & Compounds for TIMM22 Gene

No Compound Related Data Available

Transcripts for TIMM22 Gene

mRNA/cDNA for TIMM22 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIMM22 Gene

Translocase of inner mitochondrial membrane 22 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM22 Gene

No ASD Table

Relevant External Links for TIMM22 Gene

GeneLoc Exon Structure for
TIMM22
ECgene alternative splicing isoforms for
TIMM22

Expression for TIMM22 Gene

mRNA expression in normal human tissues for TIMM22 Gene

Protein differential expression in normal tissues from HIPED for TIMM22 Gene

This gene is overexpressed in Tlymphocyte (10.2) and Fetal testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM22 Gene



SOURCE GeneReport for Unigene cluster for TIMM22 Gene Hs.745034

genes like me logo Genes that share expression patterns with TIMM22: view

Protein tissue co-expression partners for TIMM22 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIMM22 Gene

Orthologs for TIMM22 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIMM22 35
  • 91.58 (n)
  • 95.36 (a)
TIMM22 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM22 35
  • 90.45 (n)
  • 94.27 (a)
TIMM22 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm22 35
  • 88.49 (n)
  • 95.36 (a)
Timm22 16
Timm22 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIMM22 35
  • 98.8 (n)
  • 98.97 (a)
TIMM22 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm22 35
  • 88.48 (n)
  • 94.24 (a)
oppossum
(Monodelphis domestica)
Mammalia TIMM22 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM22 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIMM22 35
  • 78.01 (n)
  • 84.57 (a)
TIMM22 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timm22 35
  • 76.03 (n)
  • 86.52 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537779 35
  • 71.6 (n)
  • 82.1 (a)
TIMM22 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003199 35
  • 56.35 (n)
  • 51.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31229 35
  • 57.38 (n)
  • 52.53 (a)
CG31229 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C47G2.3 35
  • 50.47 (n)
  • 44.37 (a)
C47G2.3 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM22 36
  • 29 (a)
OneToOne
TIM22 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tim22 35
  • 52.42 (n)
  • 41.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2638 36
  • 42 (a)
OneToOne
Species with no ortholog for TIMM22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM22 Gene

ENSEMBL:
Gene Tree for TIMM22 (if available)
TreeFam:
Gene Tree for TIMM22 (if available)

Paralogs for TIMM22 Gene

No data available for Paralogs for TIMM22 Gene

Variants for TIMM22 Gene

Sequence variations from dbSNP and Humsavar for TIMM22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9737 -- 1,001,743(-) CCCCC(A/G)CTTCC utr-variant-3-prime
rs333644 -- 1,002,455(+) AGGCC(C/T)GAGTG downstream-variant-500B
rs333645 -- 1,001,768(+) CAGGG(C/T)TGTTA utr-variant-3-prime
rs333646 -- 1,001,262(-) TGGCT(A/G)CCCCA utr-variant-3-prime
rs333647 -- 1,000,890(+) TGATC(A/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM22 Gene

Variant ID Type Subtype PubMed ID
esv2422420 CNV Duplication 17116639
dgv925e1 CNV Complex 17122850
esv673 CNV CNV 17122850
dgv172n21 CNV Gain 19592680
esv2751769 CNV Gain 17911159
nsv469582 CNV Complex 16826518
essv3392 CNV CNV 17122850
dgv3021n71 CNV Loss 21882294
dgv3022n71 CNV Loss 21882294
essv8 CNV CNV 17122850
nsv827852 CNV Gain 20364138
nsv907472 CNV Loss 21882294
dgv3023n71 CNV Loss 21882294
dgv3024n71 CNV Loss 21882294
nsv470566 CNV Loss 18288195
dgv3025n71 CNV Loss 21882294
dgv3026n71 CNV Loss 21882294
nsv907487 CNV Gain 21882294

Variation tolerance for TIMM22 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM22 Gene

HapMap Linkage Disequilibrium report
TIMM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM22 Gene

Disorders for TIMM22 Gene

Relevant External Links for TIMM22

Genetic Association Database (GAD)
TIMM22
Human Genome Epidemiology (HuGE) Navigator
TIMM22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM22

No disorders were found for TIMM22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM22 Gene

Publications for TIMM22 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TIMM22 Gene

Sources for TIMM22 Gene

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