Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIMM22 Gene

Aliases for TIMM22 Gene

  • Translocase Of Inner Mitochondrial Membrane 22 2 3 5
  • Testis-Expressed Sequence 4 2 3
  • Testis-Expressed Protein 4 3 4
  • TIM22 3 4
  • TEX4 3 4
  • Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast) 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim22 3
  • Translocase Of Inner Mitochondrial Membrane 22 Homolog 3

External Ids for TIMM22 Gene

Previous HGNC Symbols for TIMM22 Gene

  • TEX4

Previous GeneCards Identifiers for TIMM22 Gene

  • GC17P001158
  • GC17P000853
  • GC17P000885
  • GC17P000847
  • GC17P000900

Summaries for TIMM22 Gene

Entrez Gene Summary for TIMM22 Gene

  • Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]

GeneCards Summary for TIMM22 Gene

TIMM22 (Translocase Of Inner Mitochondrial Membrane 22) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import.

UniProtKB/Swiss-Prot for TIMM22 Gene

  • Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Gene Wiki entry for TIMM22 Gene

Additional gene information for TIMM22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM22 Gene

Genomics for TIMM22 Gene

GeneHancer (GH) Regulatory Elements for TIMM22 Gene

Promoters and enhancers for TIMM22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I000996 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 568.7 +0.1 129 2.2 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TIMM22 MYO1C RPA1 FAM57A ENSG00000262228 GEMIN4 PRPF8 GC17P001008
GH17I000998 Enhancer 0.5 ENCODE 550.8 +1.3 1299 0.2 POLR2A ZFP36 SIN3A ZBTB33 TIMM22 GC17P001008
GH17I000997 Enhancer 0.4 ENCODE 550.8 -1.0 -1021 0.1 ADNP ZBTB11 TIMM22 GC17M000988
GH17I000999 Enhancer 1.1 Ensembl ENCODE dbSUPER 30 +6.0 5992 7.4 SOX13 CTCF ZNF146 JUN ZNF133 MAX ZIC2 TEAD3 ZNF138 POLR2A TIMM22 NXN GLOD4 MYO1C INPP5K GC17P001008 ABR
GH17I000713 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 -281.6 -281561 3.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B VPS53 GC17P000714 FAM57A DBIL5P TIMM22 GLOD4 NXN GEMIN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIMM22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIMM22 gene promoter:

Genomic Locations for TIMM22 Gene

Genomic Locations for TIMM22 Gene
chr17:997,117-1,003,671
(GRCh38/hg38)
Size:
6,555 bases
Orientation:
Plus strand
chr17:900,357-906,911
(GRCh37/hg19)

Genomic View for TIMM22 Gene

Genes around TIMM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM22 Gene

Proteins for TIMM22 Gene

  • Protein details for TIMM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y584-TIM22_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim22
    Protein Accession:
    Q9Y584
    Secondary Accessions:
    • Q9NWI8

    Protein attributes for TIMM22 Gene

    Size:
    194 amino acids
    Molecular mass:
    20031 Da
    Quaternary structure:
    • Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIMM10B and the 70 kDa heterohexamer (PubMed:14726512, PubMed:27265872). In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10 (TIMM10A or TIMM10B) (PubMed:14726512). A small fraction of the 70 kDa complex is composed of TIMM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13 (PubMed:14726512). The TIM22 complex also contains AGK and TIMM29 (PubMed:27718247, PubMed:28712724, PubMed:28712726). Interacts directly with TIMM9, TIMM10A and FXC1/TIMM10B (PubMed:14726512). Interacts (when oxidized) with TIMM29; interaction is direct (PubMed:27718247).

neXtProt entry for TIMM22 Gene

Post-translational modifications for TIMM22 Gene

Other Protein References for TIMM22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM22 Gene

Domains & Families for TIMM22 Gene

Gene Families for TIMM22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TIMM22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y584

UniProtKB/Swiss-Prot:

TIM22_HUMAN :
  • Belongs to the Tim17/Tim22/Tim23 family.
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM22: view

Function for TIMM22 Gene

Molecular function for TIMM22 Gene

UniProtKB/Swiss-Prot Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Phenotypes From GWAS Catalog for TIMM22 Gene

Gene Ontology (GO) - Molecular Function for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27718247
GO:0030943 mitochondrion targeting sequence binding IBA --
genes like me logo Genes that share ontologies with TIMM22: view
genes like me logo Genes that share phenotypes with TIMM22: view

Animal Models for TIMM22 Gene

MGI Knock Outs for TIMM22:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMM22 Gene

Localization for TIMM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM22 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM22 gene
Compartment Confidence
mitochondrion 5
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS 14726512
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042721 mitochondrial inner membrane protein insertion complex IDA 27718247
genes like me logo Genes that share ontologies with TIMM22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIMM22 Gene

Pathways & Interactions for TIMM22 Gene

genes like me logo Genes that share pathways with TIMM22: view

Pathways by source for TIMM22 Gene

2 Reactome pathways for TIMM22 Gene

Gene Ontology (GO) - Biological Process for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0045039 protein import into mitochondrial inner membrane IDA,TAS 14726512
genes like me logo Genes that share ontologies with TIMM22: view

No data available for SIGNOR curated interactions for TIMM22 Gene

Drugs & Compounds for TIMM22 Gene

No Compound Related Data Available

Transcripts for TIMM22 Gene

mRNA/cDNA for TIMM22 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIMM22 Gene

Translocase of inner mitochondrial membrane 22 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM22 Gene

No ASD Table

Relevant External Links for TIMM22 Gene

GeneLoc Exon Structure for
TIMM22
ECgene alternative splicing isoforms for
TIMM22

Expression for TIMM22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM22 Gene

Protein differential expression in normal tissues from HIPED for TIMM22 Gene

This gene is overexpressed in Tlymphocyte (10.2) and Fetal testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM22 Gene



Protein tissue co-expression partners for TIMM22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIMM22 Gene:

TIMM22

SOURCE GeneReport for Unigene cluster for TIMM22 Gene:

Hs.745034

Evidence on tissue expression from TISSUES for TIMM22 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with TIMM22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM22 Gene

Orthologs for TIMM22 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM22 33 34
  • 98.8 (n)
cow
(Bos Taurus)
Mammalia TIMM22 33 34
  • 91.58 (n)
dog
(Canis familiaris)
Mammalia TIMM22 33 34
  • 90.45 (n)
oppossum
(Monodelphis domestica)
Mammalia TIMM22 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm22 33 16 34
  • 88.49 (n)
rat
(Rattus norvegicus)
Mammalia Timm22 33
  • 88.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM22 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIMM22 33 34
  • 78.01 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia timm22 33
  • 76.03 (n)
zebrafish
(Danio rerio)
Actinopterygii TIMM22 34
  • 74 (a)
OneToOne
LOC100537779 33
  • 71.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31229 33 34
  • 57.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003199 33
  • 56.35 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C47G2.3 33
  • 50.47 (n)
C47G2.3 34
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM22 34 36
  • 29 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tim22 33
  • 52.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2638 34
  • 42 (a)
OneToOne
Species where no ortholog for TIMM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM22 Gene

ENSEMBL:
Gene Tree for TIMM22 (if available)
TreeFam:
Gene Tree for TIMM22 (if available)

Paralogs for TIMM22 Gene

No data available for Paralogs for TIMM22 Gene

Variants for TIMM22 Gene

Sequence variations from dbSNP and Humsavar for TIMM22 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000283021 -- 996,868(+) C/G upstream_transcript_variant
rs1000336020 -- 996,656(+) G/A upstream_transcript_variant
rs1000952754 -- 995,909(+) A/C upstream_transcript_variant
rs1001180088 -- 1,002,226(+) A/AA downstream_transcript_variant
rs1001232458 -- 1,001,982(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM22 Gene

Variant ID Type Subtype PubMed ID
dgv172n21 CNV gain 19592680
dgv3079n100 CNV gain 25217958
dgv3080n100 CNV gain 25217958
esv2422420 CNV duplication 17116639
esv2751769 CNV gain 17911159
esv2758673 CNV gain 17122850
esv3572275 CNV gain 25503493
esv3582465 CNV loss 25503493
esv3639665 CNV gain 21293372
nsv1059578 CNV gain 25217958
nsv1064415 CNV gain 25217958
nsv1066149 CNV gain 25217958
nsv469582 CNV loss 16826518
nsv470566 CNV loss 18288195
nsv574142 CNV gain 21841781
nsv827852 CNV gain 20364138
nsv952095 CNV deletion 24416366

Variation tolerance for TIMM22 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIMM22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM22 Gene

Disorders for TIMM22 Gene

Additional Disease Information for TIMM22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TIMM22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM22 Gene

Publications for TIMM22 Gene

  1. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Mühlenbein N … Bauer MF (The Journal of biological chemistry 2004) 2 3 4 58
  2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer MF … Hofmann S (FEBS letters 1999) 2 3 4 58
  3. Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex. (PMID: 28712726) Kang Y … Stojanovski D (Molecular cell 2017) 3 4 58
  4. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. (PMID: 28712724) Vukotic M … Langer T (Molecular cell 2017) 3 4 58
  5. TIM29 is a subunit of the human carrier translocase required for protein transport. (PMID: 27718247) Callegari S … Rehling P (FEBS letters 2016) 3 4 58

Products for TIMM22 Gene

Sources for TIMM22 Gene

Content
Loading form....