Aliases for TIMM22 Gene
External Ids for TIMM22 Gene
Previous HGNC Symbols for TIMM22 Gene
Previous GeneCards Identifiers for TIMM22 Gene
Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]
GeneCards Summary for TIMM22 Gene
TIMM22 (Translocase Of Inner Mitochondrial Membrane 22) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Metabolism of proteins. GO annotations related to this gene include protein channel activity.
UniProtKB/Swiss-Prot for TIMM22 Gene
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).