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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMM22 Gene

protein-coding   GIFtS: 49
GCID: GC17P000900

Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast)

(Previous name: testis-expressed sequence 4)
(Previous symbol: TEX4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast)1 2
Testis-Expressed Sequence 41 2 3
TEX41 2 3
TIM222 3 5
Mitochondrial Import Inner Membrane Translocase Subunit Tim222
Putative Membrane Protein2

External Ids:    HGNC: 173171   Entrez Gene: 299282   Ensembl: ENSG000001773707   OMIM: 6072515   UniProtKB: Q9Y5843   

Export aliases for TIMM22 gene to outside databases

Previous GC identifers: GC17P000997 GC17P001158 GC17P000853 GC17P000885 GC17P000847


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TIMM22 Gene: 
TIMM22 (translocase of inner mitochondrial membrane 22 homolog (yeast)) is a protein-coding gene. Diseases associated with TIMM22 include blindness, and among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include protein channel activity.

UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584
Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of
multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the
voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as
external driving force in 2 voltage-dependent steps (By similarity)

Gene Wiki entry for TIMM22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMM22 gene promoter:
         STAT1   STAT1beta   MIF-1   CUTL1   STAT1alpha   AREB6   STAT3   FOXO1a   ATF   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM22 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMM22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

TIMM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM22 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P000900:  view genomic region     (about GC identifiers)

Start:
900,357 bp from pter      End:
905,407 bp from pter
Size:
5,051 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim22  
Size: 194 amino acids; 20031 Da
Subunit: Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein
FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A
small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts
directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q9NWI8

Explore the universe of human proteins at neXtProt for TIMM22: NX_Q9Y584

Explore proteomics data for TIMM22 at MOPED 

TIMM22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TIMM22 Protein Expression

REFSEQ proteins: NP_037469.2  
ENSEMBL proteins: 
 ENSP00000320236  
Reactome Protein details: Q9Y584
Human Recombinant Protein Products for TIMM22: 
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OriGene Protein Over-expression Lysate for TIMM22
OriGene Custom MassSpec 
OriGene Custom Protein Services for TIMM22
GenScript Custom Purified and Recombinant Proteins Services for TIMM22
Novus Biologicals TIMM22 Protein
Novus Biologicals TIMM22 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane TAS14726512
GO:0016021integral to membrane IEA--

TIMM22 for ontologies           About GeneDecksing



TIMM22 Antibody Products: 
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Assay Products for TIMM22: 
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Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR003397 Tim17/Tim22/Tim23/PMP24

Graphical View of Domain Structure for InterPro Entry Q9Y584

ProtoNet protein and cluster: Q9Y584

1 Blocks protein domain: IPB003397 Mitochondrial import inner membrane translocase

UniProtKB/Swiss-Prot: TIM22_HUMAN, Q9Y584
Similarity: Belongs to the Tim17/Tim22/Tim23 family


TIMM22 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TIM22_HUMAN, Q9Y584
Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of
multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the
voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as
external driving force in 2 voltage-dependent steps (By similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0015266protein channel activity TAS14726512
     
TIMM22 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for TIMM22:
 Increased G1 DNA content  Synthetic lethal with Ras 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMM22 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMM22

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMM22 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMM22 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM22
4 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM22:
hsa-miR-146b-3p hsa-miR-874 hsa-miR-1289 hsa-miR-3667-3p
SwitchGear 3'UTR luciferase reporter plasmidTIMM22 3' UTR sequence
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for TIMM22
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM22

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of TIMM22

Clone
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OriGene clones in human, mouse for TIMM22 (see all 7)
OriGene ORF clones in mouse, rat for TIMM22
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TIMM22 (NM_013337)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM22
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM22
Sirion Biotech Customized lentivirus for stable overexpression of TIMM22 
                     Customized lentivirus expression plasmids for stable overexpression of TIMM22 

Cell Line
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Search LifeMap BioReagents cell lines for TIMM22
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM22


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TIMM22 About                                                                                                See pathways by source

SuperPathContained pathways About
1Asparagine N-linked glycosylation
Metabolism of proteins0.35
2Mitochondrial Protein Import
Mitochondrial Protein Import

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2        Reactome Pathways for TIMM22
    Mitochondrial Protein Import
Metabolism of proteins



TIMM22 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIMM22

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/18 Interacting proteins for TIMM22 (Q9Y5843 ENSP000003202364) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
TIMM10P620723, ENSP000002572454I2D: score=2 STRING: ENSP00000257245
TIMM10BQ9Y5J63, ENSP000002546164I2D: score=1 STRING: ENSP00000254616
PDCD6O753403I2D: score=3 
TIMM9Q9Y5J73I2D: score=1 
TOMM20ENSP000003555664STRING: ENSP00000355566
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006626protein targeting to mitochondrion TAS--
GO:0044267cellular protein metabolic process TAS--
GO:0045039protein import into mitochondrial inner membrane TAS14726512

TIMM22 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIMM22 (TIM22)

Search CenterWatch for drugs/clinical trials and news about TIMM22 / TIM22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TIMM22 gene: 
NM_013337.2  

Unigene Cluster for TIMM22:

Translocase of inner mitochondrial membrane 22 homolog (yeast)
Hs.745034  [show with all ESTs]
Unigene Representative Sequence: NM_013337
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000327158(uc002fsc.3)
miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM22
4 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM22:
hsa-miR-146b-3p hsa-miR-874 hsa-miR-1289 hsa-miR-3667-3p
SwitchGear 3'UTR luciferase reporter plasmidTIMM22 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TIMM22
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM22
Clone
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OriGene clones in human, mouse for TIMM22 (see all 7)
OriGene ORF clones in mouse, rat for TIMM22
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GenScript: all cDNA clones in your preferred vector: TIMM22 (NM_013337)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM22
Sirion Biotech Customized lentivirus for stable overexpression of TIMM22 
                     Customized lentivirus expression plasmids for stable overexpression of TIMM22 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TIMM22
OriGene qSTAR qPCR primer pairs in human, mouse for TIMM22
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM22
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM22
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM22

Additional mRNA sequence: 

AF155330.1 AK000830.1 AK225453.1 BC002324.2 

5 DOTS entries:

DT.415240  DT.120991530  DT.100781881  DT.102836961  DT.120991525 

24/183 AceView cDNA sequences (see all 183):

AI215906 BX092484 C00900 BQ676268 AA923711 BF987769 BQ925032 AI351259 
BC002324 BF447671 AW247977 BM313598 BM762331 AA960906 CR622134 BM849278 
BM849408 AI572188 AA767469 AA242762 BF196141 BM552650 CA446624 BE218835 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIMM22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TIMM22 Expression
About this image


See TIMM22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIMM22

SOURCE GeneReport for Unigene cluster: Hs.745034
    SABiosciences Expression via Pathway-Focused PCR Array including TIMM22: 
          Mitochondria in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TIMM22
OriGene qSTAR qPCR primer pairs in human, mouse for TIMM22
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM22
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM22

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIMM22 gene from 8/17 species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Timm221 , 5 translocase of inner mitochondrial membrane 22 homolog more5
translocase of inner mitochondrial membrane 221
88.49(n)1
95.36(a)1
  11 (45.92 cM)5
563221  NM_019818.41  NP_062792.21 
 764069525 
chicken
(Gallus gallus)
Aves TIMM221 translocase of inner mitochondrial membrane 22 homolog more 78.01(n)
84.57(a)
  417594  XM_415839.3  XP_415839.3 
zebrafish
(Danio rerio)
Actinopterygii LOC1005377791 mitochondrial import inner membrane translocase subunit more 69.42(n)
77.84(a)
  100537779  XM_003198715.1  XP_003198763.1 
fruit fly
(Drosophila melanogaster)
Insecta CG312291 CG31229 54.95(n)
48.9(a)
  318636  NM_169828.2  NP_732364.1 
worm
(Caenorhabditis elegans)
Secernentea CELE_C47G2.31 Protein C47G2.3 48.55(n)
40.46(a)
  174722  NM_064011.2  NP_496412.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM22(YDL217C)4 Essential core component of the mitochondrial TIM22 more   --   4(68606-67983) 851309  NP_010064.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons MEE671 Tim17 domain-containing protein 47.29(n)
39.53(a)
  820172  NM_111846.3  NP_566368.1 
rice
(Oryza sativa)
Liliopsida Os03g02963001 hypothetical protein 51.24(n)
38.06(a)
  4332537  NM_001056363.1  NP_001049828.1 


ENSEMBL Gene Tree for TIMM22 (if available)
TreeFam Gene Tree for TIMM22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/242 SNPs in TIMM22 are shown (see all 242)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs752245481,2
C,F--898373(+) ACCATG/ACCCAG 1 -- us2k12Minor allele frequency- A:0.12NA EA 240
rs3336561,2
C,F,H--898395(-) TTGATC/TGGAAA 1 -- us2k112Minor allele frequency- T:0.02NS EA NA WA 1480
rs767181911,2
C--898473(+) AAAAAG/CTGTGC 1 -- us2k15Minor allele frequency- C:0.11CSA WA NA EA 361
rs1146897941,2
C,F--898520(+) TCATAC/TGAGGA 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1174021501,2
F--898750(+) GCCCTA/TACTGG 1 -- us2k11Minor allele frequency- T:0.02NA 120
rs1862498051,2
--898759(+) GGCCGA/GGCGCA 1 -- us2k10--------
rs778209911,2
C,F--898788(+) CCAAGC/TACTTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1909503671,2
--898809(+) GGTGGA/GTGGGT 1 -- us2k10--------
rs1832870731,2
--898960(+) AAACCC/TGGGAG 1 -- us2k10--------
rs1127854711,2
C--899007(+) CTCCAG/ACCTGG 1 -- us2k12Minor allele frequency- A:0.00CSA 2

HapMap Linkage Disequilibrium report for TIMM22 (900357 - 905407 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/18 variations for TIMM22 (see all 18):    About this table     
Variant IDTypeSubtypePubMed ID
esv2422420CNV Duplication17116639
dgv3026n71CNV Loss21882294
dgv3025n71CNV Loss21882294
dgv3024n71CNV Loss21882294
nsv470566CNV Loss18288195
dgv3021n71CNV Loss21882294
nsv907472CNV Loss21882294
dgv3022n71CNV Loss21882294
dgv3023n71CNV Loss21882294
dgv172n21CNV Gain19592680

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TIMM22
DNA2.0 Custom Variant and Variant Library Synthesis for TIMM22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607251    OMIM disorders: --

2 diseases for TIMM22:    About MalaCards
blindness    


TIMM22 for disorders           About GeneDecksing

Genetic Association Database (GAD): TIMM22
Human Genome Epidemiology (HuGE) Navigator: TIMM22 (1 document)

Export disorders for TIMM22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TIMM22 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TIMM22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
  2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)1, 2 Muhlenbein N....Bauer M.F. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2 Bauer M.F.... Hofmann S. (1999)
  6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
  7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  8. Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel. (PubMed id 11864609)1 Kovermann P....Pfanner N. (2002)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)1 Suzuki H....Hayashizaki Y. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29928 HGNC: 17317 AceView: TIMM22 Ensembl:ENSG00000177370 euGenes: HUgn29928
ECgene: TIMM22 H-InvDB: TIMM22

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TIMM22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TIMM22 gene:
Search GeneIP for patents involving TIMM22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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