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Aliases for TIMM22 Gene

Aliases for TIMM22 Gene

  • Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast) 2 3
  • Testis-Expressed Sequence 4 2 3 4
  • TIM22 3 4 6
  • TEX4 3 4
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim22 3
  • Putative Membrane Protein 3

External Ids for TIMM22 Gene

Previous HGNC Symbols for TIMM22 Gene

  • TEX4

Previous GeneCards Identifiers for TIMM22 Gene

  • GC17P001158
  • GC17P000853
  • GC17P000885
  • GC17P000847
  • GC17P000900

Summaries for TIMM22 Gene

GeneCards Summary for TIMM22 Gene

TIMM22 (Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include protein channel activity.

UniProtKB/Swiss-Prot for TIMM22 Gene

  • Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Gene Wiki entry for TIMM22 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM22 Gene

Genomics for TIMM22 Gene

Regulatory Elements for TIMM22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIMM22 Gene

Start:
997,117 bp from pter
End:
1,003,671 bp from pter
Size:
6,555 bases
Orientation:
Plus strand

Genomic View for TIMM22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM22 Gene

Proteins for TIMM22 Gene

  • Protein details for TIMM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y584-TIM22_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim22
    Protein Accession:
    Q9Y584
    Secondary Accessions:
    • Q9NWI8

    Protein attributes for TIMM22 Gene

    Size:
    194 amino acids
    Molecular mass:
    20031 Da
    Quaternary structure:
    • Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

neXtProt entry for TIMM22 Gene

Proteomics data for TIMM22 Gene at MOPED

Post-translational modifications for TIMM22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM22 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM22 Gene

Domains for TIMM22 Gene

Protein Domains for TIMM22 Gene

Suggested Antigen Peptide Sequences for TIMM22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y584

UniProtKB/Swiss-Prot:

TIM22_HUMAN :
  • Q9Y584
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM22: view

No data available for Gene Families for TIMM22 Gene

Function for TIMM22 Gene

Molecular function for TIMM22 Gene

UniProtKB/Swiss-Prot Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Gene Ontology (GO) - Molecular Function for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0015266 protein channel activity TAS 14726512
genes like me logo Genes that share ontologies with TIMM22: view

Phenotypes for TIMM22 Gene

GenomeRNAi human phenotypes for TIMM22:
genes like me logo Genes that share phenotypes with TIMM22: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM22

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TIMM22 Gene

Localization for TIMM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM22 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM22 Gene COMPARTMENTS Subcellular localization image for TIMM22 gene
Compartment Confidence
mitochondrion 5
cytosol 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS 14726512
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIMM22: view

Pathways for TIMM22 Gene

genes like me logo Genes that share pathways with TIMM22: view

Pathways by source for TIMM22 Gene

2 Reactome pathways for TIMM22 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0045039 protein import into mitochondrial inner membrane TAS 14726512
genes like me logo Genes that share ontologies with TIMM22: view

Transcripts for TIMM22 Gene

mRNA/cDNA for TIMM22 Gene

(183) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIMM22 Gene

Translocase of inner mitochondrial membrane 22 homolog (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM22 Gene

No ASD Table

Relevant External Links for TIMM22 Gene

GeneLoc Exon Structure for
TIMM22
ECgene alternative splicing isoforms for
TIMM22

Expression for TIMM22 Gene

mRNA expression in normal human tissues for TIMM22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM22 Gene

SOURCE GeneReport for Unigene cluster for TIMM22 Gene Hs.745034

genes like me logo Genes that share expressions with TIMM22: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIMM22 Gene

Orthologs for TIMM22 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM22 35
  • 98.8 (n)
  • 98.97 (a)
TIMM22 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIMM22 35
  • 91.58 (n)
  • 95.36 (a)
TIMM22 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM22 35
  • 90.45 (n)
  • 94.27 (a)
TIMM22 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm22 35
  • 88.49 (n)
  • 95.36 (a)
Timm22 16
Timm22 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM22 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM22 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm22 35
  • 88.48 (n)
  • 94.24 (a)
chicken
(Gallus gallus)
Aves TIMM22 35
  • 78.01 (n)
  • 84.57 (a)
TIMM22 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timm22 35
  • 76.03 (n)
  • 86.52 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537779 35
  • 71.6 (n)
  • 82.1 (a)
TIMM22 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003199 35
  • 56.35 (n)
  • 51.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31229 35
  • 57.38 (n)
  • 52.53 (a)
CG31229 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C47G2.3 36
  • 34 (a)
OneToOne
CELE_C47G2.3 35
  • 50.47 (n)
  • 44.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM22 36
  • 29 (a)
OneToOne
TIM22 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tim22 35
  • 52.42 (n)
  • 41.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2638 36
  • 42 (a)
OneToOne
Species with no ortholog for TIMM22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM22 Gene

ENSEMBL:
Gene Tree for TIMM22 (if available)
TreeFam:
Gene Tree for TIMM22 (if available)

Paralogs for TIMM22 Gene

No data available for Paralogs for TIMM22 Gene

Variants for TIMM22 Gene

Sequence variations from dbSNP and Humsavar for TIMM22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9737 -- 1,001,743(-) CCCCC(A/G)CTTCC utr-variant-3-prime
rs333644 -- 1,002,455(+) AGGCC(C/T)GAGTG downstream-variant-500B
rs333645 -- 1,001,768(+) CAGGG(C/T)TGTTA utr-variant-3-prime
rs333646 -- 1,001,262(-) TGGCT(A/G)CCCCA utr-variant-3-prime
rs333647 -- 1,000,890(+) TGATC(A/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM22 Gene

Variant ID Type Subtype PubMed ID
esv2422420 CNV Duplication 17116639
dgv925e1 CNV Complex 17122850
esv673 CNV CNV 17122850
dgv172n21 CNV Gain 19592680
esv2751769 CNV Gain 17911159
nsv469582 CNV Complex 16826518
essv3392 CNV CNV 17122850
dgv3021n71 CNV Loss 21882294
dgv3022n71 CNV Loss 21882294
essv8 CNV CNV 17122850
nsv827852 CNV Gain 20364138
nsv907472 CNV Loss 21882294
dgv3023n71 CNV Loss 21882294
dgv3024n71 CNV Loss 21882294
nsv470566 CNV Loss 18288195
dgv3025n71 CNV Loss 21882294
dgv3026n71 CNV Loss 21882294
nsv907487 CNV Gain 21882294

Relevant External Links for TIMM22 Gene

HapMap Linkage Disequilibrium report
TIMM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM22 Gene

Disorders for TIMM22 Gene

Relevant External Links for TIMM22

Genetic Association Database (GAD)
TIMM22
Human Genome Epidemiology (HuGE) Navigator
TIMM22
genes like me logo Genes that share disorders with TIMM22: view

No data available for UniProtKB/Swiss-Prot for TIMM22 Gene

Publications for TIMM22 Gene

  1. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer M.F. … Hofmann S. (FEBS Lett. 1999) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Muehlenbein N. … Bauer M.F. (J. Biol. Chem. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for TIMM22 Gene

Sources for TIMM22 Gene

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