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Aliases for TIMM22 Gene

Aliases for TIMM22 Gene

  • Translocase Of Inner Mitochondrial Membrane 22 2 3 5
  • Testis-Expressed Sequence 4 2 3
  • Testis-Expressed Protein 4 3 4
  • TIM22 3 4
  • TEX4 3 4
  • Translocase Of Inner Mitochondrial Membrane 22 Homolog (Yeast) 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim22 3
  • Translocase Of Inner Mitochondrial Membrane 22 Homolog 3

External Ids for TIMM22 Gene

Previous HGNC Symbols for TIMM22 Gene

  • TEX4

Previous GeneCards Identifiers for TIMM22 Gene

  • GC17P001158
  • GC17P000853
  • GC17P000885
  • GC17P000847
  • GC17P000900

Summaries for TIMM22 Gene

Entrez Gene Summary for TIMM22 Gene

  • Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]

GeneCards Summary for TIMM22 Gene

TIMM22 (Translocase Of Inner Mitochondrial Membrane 22) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. GO annotations related to this gene include protein channel activity.

UniProtKB/Swiss-Prot for TIMM22 Gene

  • Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Gene Wiki entry for TIMM22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM22 Gene

Genomics for TIMM22 Gene

Regulatory Elements for TIMM22 Gene

Enhancers for TIMM22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G000999 1.3 Ensembl ENCODE dbSUPER 30 +6.0 5993 7.4 ZNF133 SIN3A EGR1 ZNF138 GATA2 FOS ZNF263 ZNF781 CBX8 MYNN TIMM22 NXN GLOD4 MYO1C INPP5K GC17P001008
GH17G001007 0.9 ENCODE dbSUPER 26.3 +11.2 11243 2.3 PKNOX1 ZNF384 ZNF394 FOSL1 OSR2 PRDM6 SMARCA4 ZNF600 TIMM22 GC17P001008
GH17G000997 1.2 ENCODE 18.7 +0.1 130 2.2 MLX CREB3L1 DMAP1 YY1 ZNF416 ZNF143 SP3 TBX21 MEF2D ZNF610 TIMM22 RPA1 MYO1C GC17P001008
GH17G001025 1 dbSUPER 20.1 +29.7 29712 2.4 PKNOX1 FOXA2 ATF1 MLX ARID4B ZNF48 TCF12 ZNF207 SP5 MXD4 TIMM22 NXN GLOD4 MIR3183 ENSG00000278794
GH17G001037 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +42.1 42080 3.6 MAX ZIC2 ZNF664 POLR2A ZNF341 KLF9 FOXP2 SMAD4 PCBP1 HNRNPL TIMM22 NXN GLOD4 ABR MYO1C MIR3183 ENSG00000278794
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIMM22 on UCSC Golden Path with GeneCards custom track

Promoters for TIMM22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089990 83 1601 MLX CREB3L1 DMAP1 YY1 ZNF416 ZNF143 SP3 TBX21 MEF2D ZNF610

Genomic Location for TIMM22 Gene

Chromosome:
17
Start:
997,117 bp from pter
End:
1,003,671 bp from pter
Size:
6,555 bases
Orientation:
Plus strand

Genomic View for TIMM22 Gene

Genes around TIMM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM22 Gene

Proteins for TIMM22 Gene

  • Protein details for TIMM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y584-TIM22_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim22
    Protein Accession:
    Q9Y584
    Secondary Accessions:
    • Q9NWI8

    Protein attributes for TIMM22 Gene

    Size:
    194 amino acids
    Molecular mass:
    20031 Da
    Quaternary structure:
    • Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

neXtProt entry for TIMM22 Gene

Post-translational modifications for TIMM22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM22 Gene

Domains & Families for TIMM22 Gene

Gene Families for TIMM22 Gene

Suggested Antigen Peptide Sequences for TIMM22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y584

UniProtKB/Swiss-Prot:

TIM22_HUMAN :
  • Belongs to the Tim17/Tim22/Tim23 family.
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM22: view

Function for TIMM22 Gene

Molecular function for TIMM22 Gene

UniProtKB/Swiss-Prot Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Gene Ontology (GO) - Molecular Function for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27718247
GO:0015266 protein channel activity TAS 14726512
GO:0030943 mitochondrion targeting sequence binding IBA --
genes like me logo Genes that share ontologies with TIMM22: view
genes like me logo Genes that share phenotypes with TIMM22: view

Animal Models for TIMM22 Gene

MGI Knock Outs for TIMM22:

Animal Model Products

  • Taconic Biosciences Mouse Models for TIMM22

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMM22 Gene

Localization for TIMM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM22 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM22 gene
Compartment Confidence
mitochondrion 5
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS 14726512
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042721 mitochondrial inner membrane protein insertion complex IDA 27718247
genes like me logo Genes that share ontologies with TIMM22: view

Pathways & Interactions for TIMM22 Gene

genes like me logo Genes that share pathways with TIMM22: view

Pathways by source for TIMM22 Gene

2 Reactome pathways for TIMM22 Gene

Gene Ontology (GO) - Biological Process for TIMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0045039 protein import into mitochondrial inner membrane TAS 14726512
genes like me logo Genes that share ontologies with TIMM22: view

No data available for SIGNOR curated interactions for TIMM22 Gene

Drugs & Compounds for TIMM22 Gene

No Compound Related Data Available

Transcripts for TIMM22 Gene

mRNA/cDNA for TIMM22 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIMM22 Gene

Translocase of inner mitochondrial membrane 22 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM22 Gene

No ASD Table

Relevant External Links for TIMM22 Gene

GeneLoc Exon Structure for
TIMM22
ECgene alternative splicing isoforms for
TIMM22

Expression for TIMM22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM22 Gene

Protein differential expression in normal tissues from HIPED for TIMM22 Gene

This gene is overexpressed in Tlymphocyte (10.2) and Fetal testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM22 Gene



Protein tissue co-expression partners for TIMM22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIMM22 Gene:

TIMM22

SOURCE GeneReport for Unigene cluster for TIMM22 Gene:

Hs.745034

Evidence on tissue expression from TISSUES for TIMM22 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with TIMM22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM22 Gene

Orthologs for TIMM22 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM22 34 35
  • 98.8 (n)
cow
(Bos Taurus)
Mammalia TIMM22 34 35
  • 91.58 (n)
dog
(Canis familiaris)
Mammalia TIMM22 34 35
  • 90.45 (n)
oppossum
(Monodelphis domestica)
Mammalia TIMM22 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm22 34 16 35
  • 88.49 (n)
rat
(Rattus norvegicus)
Mammalia Timm22 34
  • 88.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM22 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIMM22 34 35
  • 78.01 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia timm22 34
  • 76.03 (n)
zebrafish
(Danio rerio)
Actinopterygii TIMM22 35
  • 74 (a)
OneToOne
LOC100537779 34
  • 71.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31229 34 35
  • 57.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003199 34
  • 56.35 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C47G2.3 34
  • 50.47 (n)
C47G2.3 35
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM22 35 37
  • 29 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tim22 34
  • 52.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2638 35
  • 42 (a)
OneToOne
Species where no ortholog for TIMM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM22 Gene

ENSEMBL:
Gene Tree for TIMM22 (if available)
TreeFam:
Gene Tree for TIMM22 (if available)

Paralogs for TIMM22 Gene

No data available for Paralogs for TIMM22 Gene

Variants for TIMM22 Gene

Sequence variations from dbSNP and Humsavar for TIMM22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000283021 -- 996,868(+) AGCCC(C/G)GACCG upstream-variant-2KB
rs1000336020 -- 996,656(+) CACGA(A/G)GTGGA upstream-variant-2KB
rs1000952754 -- 995,909(+) CACTA(A/C)AAATA upstream-variant-2KB
rs1001180088 -- 1,002,225(+) GGGGG(-/A)ATGAC downstream-variant-500B
rs1001232458 -- 1,001,982(+) TGTGG(C/T)CATCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIMM22 Gene

Variant ID Type Subtype PubMed ID
dgv172n21 CNV gain 19592680
dgv3079n100 CNV gain 25217958
dgv3080n100 CNV gain 25217958
esv2422420 CNV duplication 17116639
esv2751769 CNV gain 17911159
esv2758673 CNV gain 17122850
esv3572275 CNV gain 25503493
esv3582465 CNV loss 25503493
esv3639665 CNV gain 21293372
nsv1059578 CNV gain 25217958
nsv1064415 CNV gain 25217958
nsv1066149 CNV gain 25217958
nsv469582 CNV loss 16826518
nsv470566 CNV loss 18288195
nsv574142 CNV gain 21841781
nsv827852 CNV gain 20364138
nsv952095 CNV deletion 24416366

Variation tolerance for TIMM22 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM22 Gene

Disorders for TIMM22 Gene

Relevant External Links for TIMM22

Genetic Association Database (GAD)
TIMM22
Human Genome Epidemiology (HuGE) Navigator
TIMM22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM22

No disorders were found for TIMM22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM22 Gene

Publications for TIMM22 Gene

  1. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Muehlenbein N. … Bauer M.F. (J. Biol. Chem. 2004) 2 3 4 64
  2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer M.F. … Hofmann S. (FEBS Lett. 1999) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TIMM22 Gene

Sources for TIMM22 Gene

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