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Aliases for TIMM21 Gene

Aliases for TIMM21 Gene

  • Translocase Of Inner Mitochondrial Membrane 21 Homolog (Yeast) 2 3
  • TIM21 3 4 6
  • TIM21-Like Protein, Mitochondrial 3 4
  • C18orf55 3 4
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim21 3
  • Chromosome 18 Open Reading Frame 55 2
  • HSPC154 3

External Ids for TIMM21 Gene

Previous Symbols for TIMM21 Gene

  • C18orf55

Summaries for TIMM21 Gene

GeneCards Summary for TIMM21 Gene

TIMM21 (Translocase Of Inner Mitochondrial Membrane 21 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import.

UniProtKB/Swiss-Prot for TIMM21 Gene

  • Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM21 Gene

Genomics for TIMM21 Gene

Genomic Location for TIMM21 Gene

Start:
74,148,511 bp from pter
End:
74,160,530 bp from pter
Size:
12,020 bases
Orientation:
Plus strand

Genomic View for TIMM21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM21 Gene

No data available for Regulatory Elements for TIMM21 Gene

Proteins for TIMM21 Gene

  • Protein details for TIMM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVV7-TIM21_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim21
    Protein Accession:
    Q9BVV7
    Secondary Accessions:
    • Q9P010

    Protein attributes for TIMM21 Gene

    Size:
    248 amino acids
    Molecular mass:
    28202 Da
    Quaternary structure:
    • Component of the TIM23 complex. Component of some MITRAC complex.

neXtProt entry for TIMM21 Gene

Proteomics data for TIMM21 Gene at MOPED

Post-translational modifications for TIMM21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM21 Gene

Domains for TIMM21 Gene

Protein Domains for TIMM21 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TIM21_HUMAN
Family:
  • Belongs to the TIM21 family.:
    • Q9BVV7
genes like me logo Genes that share domains with TIMM21: view

No data available for Gene Families for TIMM21 Gene

Function for TIMM21 Gene

Molecular function for TIMM21 Gene

UniProtKB/Swiss-Prot Function: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

Gene Ontology (GO) - Molecular Function for TIMM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23260140
genes like me logo Genes that share ontologies with TIMM21: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TIMM21 Gene

Localization for TIMM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM21 Gene

Mitochondrion membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TIMM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component --
GO:0005739 mitochondrion --
GO:0005744 mitochondrial inner membrane presequence translocase complex IDA 23260140
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIMM21: view

Pathways for TIMM21 Gene

genes like me logo Genes that share pathways with TIMM21: view

Pathways by source for TIMM21 Gene

2 Reactome pathways for TIMM21 Gene

Gene Ontology (GO) - Biological Process for TIMM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0030150 protein import into mitochondrial matrix IMP 23260140
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 23260140
GO:0033617 mitochondrial respiratory chain complex IV assembly IMP 23260140
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TIMM21: view

Transcripts for TIMM21 Gene

Unigene Clusters for TIMM21 Gene

Translocase of inner mitochondrial membrane 21 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TIMM21 Gene

GeneLoc Exon Structure for
TIMM21
ECgene alternative splicing isoforms for
TIMM21

Expression for TIMM21 Gene

mRNA expression in normal human tissues for TIMM21 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM21 Gene

SOURCE GeneReport for Unigene cluster for TIMM21 Gene Hs.532835

genes like me logo Genes that share expressions with TIMM21: view

Orthologs for TIMM21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM21 36
  • 99.46 (n)
  • 99.19 (a)
TIMM21 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIMM21 36
  • 81.97 (n)
  • 75.41 (a)
TIMM21 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM21 36
  • 82.38 (n)
  • 77.46 (a)
TIMM21 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm21 36
  • 77.73 (n)
  • 69.67 (a)
Timm21 16
Timm21 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM21 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Timm21 36
  • 79.46 (n)
  • 72.24 (a)
chicken
(Gallus gallus)
Aves C18ORF55 36
  • 65.44 (n)
  • 63.13 (a)
TIMM21 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIMM21 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10854 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5951 36
timm21 36
  • 71.06 (n)
  • 71.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-118j18.1 36
  • 67.44 (n)
  • 65.12 (a)
TIMM21 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008572 36
  • 49.9 (n)
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7382 36
  • 48.59 (n)
  • 39.76 (a)
CG7382 37
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56B3.11 36
  • 43.88 (n)
  • 34.53 (a)
F56B3.11 37
  • 28 (a)
OneToOne
Species with no ortholog for TIMM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM21 Gene

ENSEMBL:
Gene Tree for TIMM21 (if available)
TreeFam:
Gene Tree for TIMM21 (if available)

Paralogs for TIMM21 Gene

Selected SIMAP similar genes for TIMM21 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TIMM21: view

No data available for Paralogs for TIMM21 Gene

Variants for TIMM21 Gene

Sequence variations from dbSNP and Humsavar for TIMM21 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs8148 -- 74,158,484(+) AAAAT(A/G)GGGTT utr-variant-3-prime
rs9411 -- 74,158,606(-) AAATA(C/T)TGTAT utr-variant-3-prime
rs3737513 -- 74,155,086(+) GCAGC(A/G)GACAA intron-variant
rs3794949 -- 74,157,649(-) CACTG(A/C)ACTCC intron-variant
rs5826305 -- 74,159,281(+) TAAAG(-/AA)AAAAA downstream-variant-500B

Relevant External Links for TIMM21 Gene

HapMap Linkage Disequilibrium report
TIMM21

No data available for Structural Variations from Database of Genomic Variants (DGV) for TIMM21 Gene

Disorders for TIMM21 Gene

No disorders were found for TIMM21 Gene.

No data available for UniProtKB/Swiss-Prot for TIMM21 Gene

Publications for TIMM21 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PMID: 23260140) Mick D.U. … Rehling P. (Cell 2012) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TIMM21 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TIMM21
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM21
    • Block miRNA regulation of TIMM21 using miScript Target Protectors

    Sources for TIMM21 Gene

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