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Aliases for TIMM21 Gene

Aliases for TIMM21 Gene

  • Translocase Of Inner Mitochondrial Membrane 21 2 3 5
  • TIM21-Like Protein, Mitochondrial 3 4
  • C18orf55 3 4
  • TIM21 3 4
  • Translocase Of Inner Mitochondrial Membrane 21 Homolog (Yeast) 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim21 3
  • Translocase Of Inner Mitochondrial Membrane 21 Homolog 3
  • Chromosome 18 Open Reading Frame 55 2
  • HSPC154 3

External Ids for TIMM21 Gene

Previous HGNC Symbols for TIMM21 Gene

  • C18orf55

Previous GeneCards Identifiers for TIMM21 Gene

  • GC18P071816

Summaries for TIMM21 Gene

GeneCards Summary for TIMM21 Gene

TIMM21 (Translocase Of Inner Mitochondrial Membrane 21) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Metabolism of proteins.

UniProtKB/Swiss-Prot for TIMM21 Gene

  • Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM21 Gene

Genomics for TIMM21 Gene

Regulatory Elements for TIMM21 Gene

Enhancers for TIMM21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F074082 1.2 FANTOM5 Ensembl ENCODE 12.8 -64.9 -64889 3.1 ELF3 CTCF KLF11 ZNF792 REST ZNF48 RAD21 KAT8 GABPB1 ZNF143 TIMM21 FBXO15 CYB5A ENSG00000263655
GH18F074139 1.3 FANTOM5 Ensembl ENCODE 11.5 -8.3 -8340 1.3 ZNF316 STAT2 FOS NFE2 MAFK NFE2L2 NR4A1 JUNB MAFG MEF2D TIMM21 FBXO15 ENSG00000263655
GH18F074146 1.1 ENCODE 12.8 -0.4 -434 3.8 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF407 TIMM21 CYB5A FBXO15
GH18F074062 0.9 FANTOM5 Ensembl ENCODE 12.2 -83.7 -83709 3.7 ATF2 TIMM21 FBXO15 ENSG00000263655
GH18F074013 1.1 FANTOM5 Ensembl ENCODE 7.3 -134.3 -134345 0.5 BHLHE40 CEBPB TCF7 JUNB EP300 MAFK TCF7L2 TIMM21 CNDP2 ENSG00000263655 ENSG00000278902
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIMM21 on UCSC Golden Path with GeneCards custom track

Promoters for TIMM21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001516356 -111 2801 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for TIMM21 Gene

Chromosome:
18
Start:
74,148,511 bp from pter
End:
74,160,530 bp from pter
Size:
12,020 bases
Orientation:
Plus strand

Genomic View for TIMM21 Gene

Genes around TIMM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM21 Gene

Proteins for TIMM21 Gene

  • Protein details for TIMM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVV7-TIM21_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim21
    Protein Accession:
    Q9BVV7
    Secondary Accessions:
    • Q9P010

    Protein attributes for TIMM21 Gene

    Size:
    248 amino acids
    Molecular mass:
    28202 Da
    Quaternary structure:
    • Component of the TIM23 complex. Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14 (Probable) (PubMed:23260140). Interacts with COA3 AND MT-CO1/COX1 (PubMed:26321642).

neXtProt entry for TIMM21 Gene

Post-translational modifications for TIMM21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM21 Gene

No data available for DME Specific Peptides for TIMM21 Gene

Domains & Families for TIMM21 Gene

Protein Domains for TIMM21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIMM21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVV7

UniProtKB/Swiss-Prot:

TIM21_HUMAN :
  • Belongs to the TIM21 family.
Family:
  • Belongs to the TIM21 family.
genes like me logo Genes that share domains with TIMM21: view

No data available for Gene Families for TIMM21 Gene

Function for TIMM21 Gene

Molecular function for TIMM21 Gene

UniProtKB/Swiss-Prot Function:
Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

Gene Ontology (GO) - Molecular Function for TIMM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23260140
genes like me logo Genes that share ontologies with TIMM21: view

Phenotypes for TIMM21 Gene

GenomeRNAi human phenotypes for TIMM21:
genes like me logo Genes that share phenotypes with TIMM21: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIMM21 Gene

Localization for TIMM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM21 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM21 gene
Compartment Confidence
mitochondrion 5
nucleus 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TIMM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005744 mitochondrial inner membrane presequence translocase complex IEA,IDA 23260140
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with TIMM21: view

Pathways & Interactions for TIMM21 Gene

genes like me logo Genes that share pathways with TIMM21: view

Pathways by source for TIMM21 Gene

2 Reactome pathways for TIMM21 Gene

Gene Ontology (GO) - Biological Process for TIMM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030150 protein import into mitochondrial matrix IEA,IMP 23260140
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 23260140
GO:0033617 mitochondrial respiratory chain complex IV assembly IMP 23260140
genes like me logo Genes that share ontologies with TIMM21: view

No data available for SIGNOR curated interactions for TIMM21 Gene

Transcripts for TIMM21 Gene

Unigene Clusters for TIMM21 Gene

Translocase of inner mitochondrial membrane 21 homolog (yeast):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TIMM21 Gene

GeneLoc Exon Structure for
TIMM21
ECgene alternative splicing isoforms for
TIMM21

Expression for TIMM21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIMM21 Gene

Protein differential expression in normal tissues from HIPED for TIMM21 Gene

This gene is overexpressed in Bone (26.7) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM21 Gene



Protein tissue co-expression partners for TIMM21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIMM21 Gene:

TIMM21

SOURCE GeneReport for Unigene cluster for TIMM21 Gene:

Hs.532835
genes like me logo Genes that share expression patterns with TIMM21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIMM21 Gene

Orthologs for TIMM21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM21 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia TIMM21 34 35
  • 82.38 (n)
cow
(Bos Taurus)
Mammalia TIMM21 34 35
  • 81.97 (n)
rat
(Rattus norvegicus)
Mammalia Timm21 34
  • 79.46 (n)
mouse
(Mus musculus)
Mammalia Timm21 34 16 35
  • 77.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 76 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TIMM21 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18ORF55 34
  • 65.44 (n)
TIMM21 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIMM21 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timm21 34
  • 71.06 (n)
Str.5951 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10854 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-118j18.1 34
  • 67.44 (n)
TIMM21 35
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008572 34
  • 49.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7382 34 35
  • 48.59 (n)
worm
(Caenorhabditis elegans)
Secernentea F56B3.11 34 35
  • 43.88 (n)
Species where no ortholog for TIMM21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM21 Gene

ENSEMBL:
Gene Tree for TIMM21 (if available)
TreeFam:
Gene Tree for TIMM21 (if available)

Paralogs for TIMM21 Gene

(1) SIMAP similar genes for TIMM21 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TIMM21: view

No data available for Paralogs for TIMM21 Gene

Variants for TIMM21 Gene

Sequence variations from dbSNP and Humsavar for TIMM21 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10164041 -- 74,152,055(+) gagca(A/G)cacgt intron-variant
rs111662061 -- 74,156,357(+) CTGGG(A/G)CCCCG intron-variant
rs111665930 -- 74,152,793(+) ACGTC(C/T)TGAGG intron-variant
rs111793268 -- 74,149,597(+) GTAGG(-/A)AAAAA intron-variant, upstream-variant-2KB
rs111971891 -- 74,157,658(+) TGGCA(C/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM21 Gene

Variant ID Type Subtype PubMed ID
nsv577650 CNV loss 21841781
esv3643105 CNV loss 21293372
esv27743 CNV loss 19812545
dgv3400n100 CNV gain 25217958

Variation tolerance for TIMM21 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM21 Gene

Disorders for TIMM21 Gene

Relevant External Links for TIMM21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM21

No disorders were found for TIMM21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM21 Gene

Publications for TIMM21 Gene

  1. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PMID: 23260140) Mick D.U. … Rehling P. (Cell 2012) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly. (PMID: 26321642) Dennerlein S. … Rehling P. (Cell Rep 2015) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for TIMM21 Gene

Sources for TIMM21 Gene

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