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TIMM21 Gene

protein-coding   GIFtS: 46
GCID: GC18P071816

Translocase Of Inner Mitochondrial Membrane 21 Homolog (Yeast)

(Previous name: chromosome 18 open reading frame 55)
(Previous symbol: C18orf55)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Inner Mitochondrial Membrane 21 Homolog (Yeast)1 2
C18orf551 2 3
TIM212 3 5
TIM21-Like Protein, Mitochondrial2 3
Chromosome 18 Open Reading Frame 551
Mitochondrial Import Inner Membrane Translocase Subunit Tim212

External Ids:    HGNC: 250101   Entrez Gene: 290902   Ensembl: ENSG000000753367   OMIM: 6151805   UniProtKB: Q9BVV73   

Export aliases for TIMM21 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TIMM21 Gene:
TIMM21 (translocase of inner mitochondrial membrane 21 homolog (yeast)) is a protein-coding gene.

UniProtKB/Swiss-Prot: TIM21_HUMAN, Q9BVV7
Function: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner
membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of
some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between
the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation
of early nuclear-encoded subunits into these complexes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TIMM21
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TIMM21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMM21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

TIMM21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM21 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P071816:  view genomic region     (about GC identifiers)

Start:
71,815,746 bp from pter      End:
71,826,204 bp from pter
Size:
10,459 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIM21_HUMAN, Q9BVV7 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim21 precursor  
Size: 248 amino acids; 28202 Da
Subunit: Component of the TIM23 complex. Component of some MITRAC complex
Secondary accessions: Q9P010

Explore the universe of human proteins at neXtProt for TIMM21: NX_Q9BVV7

Explore proteomics data for TIMM21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIMM21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054896.2  
    ENSEMBL proteins: 
     ENSP00000169551   ENSP00000462028   ENSP00000464228  
    Reactome Protein details: Q9BVV7

    TIMM21 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for TIMM21
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    Novus Biologicals TIMM21 Protein
    Novus Biologicals TIMM21 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TIMM21 

    TIMM21 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for TIMM21
    Novus Biologicals TIMM21 Antibodies
    Abcam antibodies for TIMM21
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for TIMM21
    Search LSBio for Antibodies for TIMM21

    TIMM21 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TIMM21
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIMM21
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TIMM21 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013261 Tim21

    Graphical View of Domain Structure for InterPro Entry Q9BVV7

    ProtoNet protein and cluster: Q9BVV7

    UniProtKB/Swiss-Prot: TIM21_HUMAN, Q9BVV7
    Similarity: Belongs to the TIM21 family


    Find genes that share domains with TIMM21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM21_HUMAN, Q9BVV7
    Function: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner
    membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of
    some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between
    the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation
    of early nuclear-encoded subunits into these complexes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with TIMM21           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIMM21
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIMM21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMM21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMM21

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TIMM21 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TIMM21
    SwitchGear 3'UTR luciferase reporter plasmidTIMM21 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIMM21
    Predesigned siRNA for gene silencing in human, mouse, rat TIMM21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMM21

    Clone
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    OriGene clones in human, mouse for TIMM21 (see all 8)
    OriGene ORF clones in mouse, rat for TIMM21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TIMM21
    Sino Biological Human cDNA Clone for TIMM21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM21

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TIMM21 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIM21_HUMAN, Q9BVV7: Mitochondrion membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion ----
    GO:0005744mitochondrial inner membrane presequence translocase complex IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TIMM21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TIMM21 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import


    Find genes that share SuperPaths with TIMM21           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TIMM21
        Mitochondrial protein import


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIMM21
    Interactions:

        Search GeneGlobe Interaction Network for TIMM21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIMM21 (Q9BVV71, 2, 3 ENSP000001695514) via UniProtKB, MINT, STRING, and/or I2D (see all 297)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PMPCAQ107132, ENSP000003607824MINT-8079030 STRING: ENSP00000360782
    PMPCBO754392, ENSP000002492694MINT-8079030 STRING: ENSP00000249269
    TIMM23O149251, ENSP000002608674EBI-6570759,EBI-1047996 STRING: ENSP00000260867
    ICT1Q141972, ENSP000003015854MINT-8079030 STRING: ENSP00000301585
    UQCRC1P319302, ENSP000002034074MINT-8079030 STRING: ENSP00000203407
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0030150protein import into mitochondrial matrix IMP--
    GO:0032981mitochondrial respiratory chain complex I assembly IMP--
    GO:0033617mitochondrial respiratory chain complex IV assembly IMP--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with TIMM21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIMM21 (TIM21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIMM21 gene: 
    NM_014177.2  

    Unigene Cluster for TIMM21:

    Translocase of inner mitochondrial membrane 21 homolog (yeast)
    Hs.532835  [show with all ESTs]
    Unigene Representative Sequence: NM_014177
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000169551(uc010dqr.1) ENST00000580087 ENST00000577952 ENST00000581467
    ENST00000584925 ENST00000579071
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate TIMM21
    SwitchGear 3'UTR luciferase reporter plasmidTIMM21 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TIMM21
    Predesigned siRNA for gene silencing in human, mouse, rat TIMM21
    Clone
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    OriGene clones in human, mouse for TIMM21 (see all 8)
    OriGene ORF clones in mouse, rat for TIMM21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TIMM21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM21
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIMM21
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMM21
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat TIMM21
      QuantiTect SYBR Green Assays in human, mouse, rat TIMM21
      QuantiFast Probe-based Assays in human, mouse, rat TIMM21

    Additional mRNA sequence: 

    AF161503.1 AK289923.1 AK313936.1 BC000892.1 

    8 DOTS entries:

    DT.440786  DT.92432925  DT.95105550  DT.121090116  DT.92432928  DT.100695354  DT.121090102  DT.121090117 

    Selected AceView cDNA sequences (see all 183):

    AA651908 AA235049 BE796305 Z38776 BG944580 BE045352 BE905768 BI488927 
    AA744923 BM693318 CB161092 BM976803 BC000892 AI417557 CB216899 BM822039 
    T32827 AI627948 AA451896 BE876007 CD674375 BX119425 BQ431656 CR620926 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM21    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -           -                                 
    SP2:                          -           -                                 
    SP3:                                      -                                 
    SP4:                          -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for TIMM21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIMM21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAAAGG
    TIMM21 Expression
    About this image

    TIMM21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIMM21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532835
        Custom PCR Arrays for TIMM21
    Primer
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    OriGene qPCR primer pairs and template standards for TIMM21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TIMM21 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm211 , 5 RIKEN cDNA 1700034H14 gene5
    tranlocase of inner mitochondrial membrane 211
    77.73(n)1
    69.67(a)1
      18 (57.53 cM)5
    671051  NM_025969.41  NP_080245.11 
     849472945 
    chicken
    (Gallus gallus)
    Aves C18ORF551 chromosome 2 open reading frame, human C18orf55 65.44(n)
    63.13(a)
      421016  XM_419102.4  XP_419102.2 
    lizard
    (Anolis carolinensis)
    Reptilia TIMM216
    translocase of inner mitochondrial membrane 21 hom...
    57(a)
    1 ↔ 1
    4(49007743-49019165)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.108542 Xenopus laevis transcribed sequence with weak similarity more 79.54(n)    BX853815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-118j18.11 si:dkey-118j18.1 67.44(n)
    65.12(a)
      560369  XM_683774.4  XP_688866.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73821 CG7382 48.59(n)
    39.76(a)
      33772  NM_135085.2  NP_608929.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F56B3.111 F56B3.11 43.88(n)
    34.53(a)
      176907  NM_067590.4  NP_499991.1 


    ENSEMBL Gene Tree for TIMM21 (if available)
    TreeFam Gene Tree for TIMM21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIMM21 gene
    1 SIMAP similar gene for TIMM21 using alignment to 3 protein entries:     TIM21_HUMAN (see all proteins):
    C18orf55

    Find genes that share paralogs with TIMM21           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIMM21 (see all 239)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734765811,2
    C--71817161(+) TCAGAC/GGTGAC 1 -- int14Minor allele frequency- G:0.14WA NA EA 360
    rs734765821,2
    C--71817201(+) GCAACA/GTTCCC 1 -- int13Minor allele frequency- G:0.20WA EA 240
    rs801173301,2
    C,F--71817233(+) CAGAAT/GTCAAA 1 -- int13Minor allele frequency- G:0.09WA NA EA 358
    rs734765851,2
    C--71817239(+) TCAAAC/GAGGCC 1 -- int14Minor allele frequency- G:0.14WA NA EA 360
    rs563091471,2
    C,F--71817305(+) ATGTCT/CTGGCA 1 -- int19Minor allele frequency- C:0.37WA NA CSA EA 368
    rs1491119131,2
    --71817311(+) TGGCAC/TGCCCC 1 -- int10--------
    rs1421440581,2
    C--71817341(+) GGCTCA/GTGTGT 1 -- int10--------
    rs99488051,2
    C,F,A,H--71817485(+) ATTCTC/GCTGAA 1 -- int123Minor allele frequency- G:0.15NS EA NA WA 2762
    rs99488221,2
    C,F,H--71817538(+) atgtcC/Gtatat 1 -- int18Minor allele frequency- G:0.14NS EA WA NA 780
    rs778882891,2
    F--71817540(+) GTCCTA/GTATCT 1 -- int11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for TIMM21 (71815746 - 71826204 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TIMM21: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMM21
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615180    OMIM disorders: --


    Find genes that share disorders with TIMM21           About GenesLikeMe


    Export disorders for TIMM21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIMM21 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TIMM21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PubMed id 23260140)1, 2 Mick D.U.... Rehling P. (Cell 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. (PubMed id 23741361)1 Wang W....Zhou Y. (PLoS ONE 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29090 HGNC: 25010 AceView: HSPC154 Ensembl:ENSG00000075336 euGenes: HUgn29090
    ECgene: TIMM21 H-InvDB: TIMM21

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TIMM21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TIMM21 gene:
    Search GeneIP for patents involving TIMM21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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