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Aliases for TIMM21 Gene

Aliases for TIMM21 Gene

  • Translocase Of Inner Mitochondrial Membrane 21 2 3
  • Translocase Of Inner Mitochondrial Membrane 21 Homolog (Yeast) 2 5
  • TIM21-Like Protein, Mitochondrial 3 4
  • C18orf55 3 4
  • TIM21 3 4
  • Translocase Of Inner Mitochondrial Membrane 21 Homolog 3
  • Chromosome 18 Open Reading Frame 55 2
  • HSPC154 3

External Ids for TIMM21 Gene

Previous HGNC Symbols for TIMM21 Gene

  • C18orf55

Previous GeneCards Identifiers for TIMM21 Gene

  • GC18P071816

Summaries for TIMM21 Gene

GeneCards Summary for TIMM21 Gene

TIMM21 (Translocase Of Inner Mitochondrial Membrane 21) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import.

UniProtKB/Swiss-Prot for TIMM21 Gene

  • Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM21 Gene

Genomics for TIMM21 Gene

Regulatory Elements for TIMM21 Gene

Promoters for TIMM21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIMM21 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIMM21 Gene

Chromosome:
18
Start:
74,148,511 bp from pter
End:
74,160,530 bp from pter
Size:
12,020 bases
Orientation:
Plus strand

Genomic View for TIMM21 Gene

Genes around TIMM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM21 Gene

Proteins for TIMM21 Gene

  • Protein details for TIMM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVV7-TIM21_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim21
    Protein Accession:
    Q9BVV7
    Secondary Accessions:
    • Q9P010

    Protein attributes for TIMM21 Gene

    Size:
    248 amino acids
    Molecular mass:
    28202 Da
    Quaternary structure:
    • Component of the TIM23 complex. Component of some MITRAC complex.

neXtProt entry for TIMM21 Gene

Proteomics data for TIMM21 Gene at MOPED

Post-translational modifications for TIMM21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM21 Gene

Domains & Families for TIMM21 Gene

Protein Domains for TIMM21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIMM21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVV7

UniProtKB/Swiss-Prot:

TIM21_HUMAN :
  • Belongs to the TIM21 family.
Family:
  • Belongs to the TIM21 family.
genes like me logo Genes that share domains with TIMM21: view

No data available for Gene Families for TIMM21 Gene

Function for TIMM21 Gene

Molecular function for TIMM21 Gene

UniProtKB/Swiss-Prot Function:
Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

Phenotypes for TIMM21 Gene

GenomeRNAi human phenotypes for TIMM21:
genes like me logo Genes that share phenotypes with TIMM21: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIMM21 Gene

Localization for TIMM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM21 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM21 Gene COMPARTMENTS Subcellular localization image for TIMM21 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TIMM21 Gene

Pathways & Interactions for TIMM21 Gene

genes like me logo Genes that share pathways with TIMM21: view

Pathways by source for TIMM21 Gene

2 Reactome pathways for TIMM21 Gene

Gene Ontology (GO) - Biological Process for TIMM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 23260140
genes like me logo Genes that share ontologies with TIMM21: view

No data available for SIGNOR curated interactions for TIMM21 Gene

Drugs & Compounds for TIMM21 Gene

No Compound Related Data Available

Transcripts for TIMM21 Gene

Unigene Clusters for TIMM21 Gene

Translocase of inner mitochondrial membrane 21 homolog (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TIMM21 Gene

GeneLoc Exon Structure for
TIMM21
ECgene alternative splicing isoforms for
TIMM21

Expression for TIMM21 Gene

mRNA expression in normal human tissues for TIMM21 Gene

Protein differential expression in normal tissues from HIPED for TIMM21 Gene

This gene is overexpressed in Bone (26.7) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM21 Gene



SOURCE GeneReport for Unigene cluster for TIMM21 Gene Hs.532835

genes like me logo Genes that share expression patterns with TIMM21: view

Protein tissue co-expression partners for TIMM21 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIMM21 Gene

Orthologs for TIMM21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIMM21 35
  • 81.97 (n)
  • 75.41 (a)
TIMM21 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM21 35
  • 82.38 (n)
  • 77.46 (a)
TIMM21 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm21 35
  • 77.73 (n)
  • 69.67 (a)
Timm21 16
Timm21 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIMM21 35
  • 99.46 (n)
  • 99.19 (a)
TIMM21 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm21 35
  • 79.46 (n)
  • 72.24 (a)
oppossum
(Monodelphis domestica)
Mammalia TIMM21 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves C18ORF55 35
  • 65.44 (n)
  • 63.13 (a)
TIMM21 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIMM21 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5951 35
timm21 35
  • 71.06 (n)
  • 71.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10854 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-118j18.1 35
  • 67.44 (n)
  • 65.12 (a)
TIMM21 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008572 35
  • 49.9 (n)
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7382 35
  • 48.59 (n)
  • 39.76 (a)
CG7382 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56B3.11 35
  • 43.88 (n)
  • 34.53 (a)
F56B3.11 36
  • 28 (a)
OneToOne
Species with no ortholog for TIMM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM21 Gene

ENSEMBL:
Gene Tree for TIMM21 (if available)
TreeFam:
Gene Tree for TIMM21 (if available)

Paralogs for TIMM21 Gene

(1) SIMAP similar genes for TIMM21 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TIMM21: view

No data available for Paralogs for TIMM21 Gene

Variants for TIMM21 Gene

Sequence variations from dbSNP and Humsavar for TIMM21 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_052306 -
rs8148 -- 74,158,484(+) AAAAT(A/C/G)GGGTT utr-variant-3-prime
rs9411 -- 74,158,606(-) AAATA(C/T)TGTAT utr-variant-3-prime
rs3737513 -- 74,155,086(+) GCAGC(A/G)GACAA intron-variant
rs3794949 -- 74,157,649(-) CACTG(A/C)ACTCC intron-variant

Variation tolerance for TIMM21 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM21 Gene

HapMap Linkage Disequilibrium report
TIMM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIMM21 Gene

Disorders for TIMM21 Gene

Relevant External Links for TIMM21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM21

No disorders were found for TIMM21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM21 Gene

Publications for TIMM21 Gene

  1. MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. (PMID: 23260140) Mick D.U. … Rehling P. (Cell 2012) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. (PMID: 23741361) Wang W. … Zhou Y. (PLoS ONE 2013) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for TIMM21 Gene

Sources for TIMM21 Gene

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