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Aliases for TIMM17B Gene

Aliases for TIMM17B Gene

  • Translocase Of Inner Mitochondrial Membrane 17 Homolog B (Yeast) 2 3
  • TIM17B 3 4 6
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim17-B 3
  • Inner Mitochondrial Membrane Preprotein Translocase 3
  • DXS9822 3
  • JM3 3

External Ids for TIMM17B Gene

Previous GeneCards Identifiers for TIMM17B Gene

  • GC0XM047553
  • GC0XM047011
  • GC0XM047796
  • GC0XM048506
  • GC0XM048635
  • GC0XM048750
  • GC0XM046406

Summaries for TIMM17B Gene

Entrez Gene Summary for TIMM17B Gene

  • This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for TIMM17B Gene

TIMM17B (Translocase Of Inner Mitochondrial Membrane 17 Homolog B (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM17A.

UniProtKB/Swiss-Prot for TIMM17B Gene

  • Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM17B Gene

Genomics for TIMM17B Gene

Regulatory Elements for TIMM17B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIMM17B Gene

48,893,447 bp from pter
48,898,143 bp from pter
4,697 bases
Minus strand

Genomic View for TIMM17B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM17B Gene

Proteins for TIMM17B Gene

  • Protein details for TIMM17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim17-B
    Protein Accession:
    Secondary Accessions:
    • A8K2E2
    • J3KPV3
    • Q9UJV0

    Protein attributes for TIMM17B Gene

    172 amino acids
    Molecular mass:
    18273 Da
    Quaternary structure:
    • Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.

    Alternative splice isoforms for TIMM17B Gene


neXtProt entry for TIMM17B Gene

Proteomics data for TIMM17B Gene at MOPED

Post-translational modifications for TIMM17B Gene

  • Ubiquitination at Lys86
  • Modification sites at PhosphoSitePlus

Other Protein References for TIMM17B Gene

No data available for DME Specific Peptides for TIMM17B Gene

Domains for TIMM17B Gene

Protein Domains for TIMM17B Gene

Suggested Antigen Peptide Sequences for TIMM17B Gene

Graphical View of Domain Structure for InterPro Entry



  • O60830
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM17B: view

No data available for Gene Families for TIMM17B Gene

Function for TIMM17B Gene

Molecular function for TIMM17B Gene

UniProtKB/Swiss-Prot Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane

Gene Ontology (GO) - Molecular Function for TIMM17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TIMM17B: view

Animal Model Products

CRISPR Products

miRNA for TIMM17B Gene

miRTarBase miRNAs that target TIMM17B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM17B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIMM17B Gene

Localization for TIMM17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM17B Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TIMM17B Gene COMPARTMENTS Subcellular localization image for TIMM17B gene
Compartment Confidence
mitochondrion 5
cytoskeleton 4
plasma membrane 2
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TIMM17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IDA 20053669
GO:0005744 mitochondrial inner membrane presequence translocase complex IDA 10339406
GO:0016021 integral component of membrane --
GO:0031305 integral component of mitochondrial inner membrane IDA 10339406
genes like me logo Genes that share ontologies with TIMM17B: view

Pathways for TIMM17B Gene

genes like me logo Genes that share pathways with TIMM17B: view

Pathways by source for TIMM17B Gene

2 Reactome pathways for TIMM17B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TIMM17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006886 intracellular protein transport --
GO:0044267 cellular protein metabolic process TAS --
GO:0071806 protein transmembrane transport IEA --
genes like me logo Genes that share ontologies with TIMM17B: view

Transcripts for TIMM17B Gene

Unigene Clusters for TIMM17B Gene

Translocase of inner mitochondrial membrane 17 homolog B (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM17B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM17B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for TIMM17B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMM17B Gene

mRNA expression in normal human tissues for TIMM17B Gene

Protein differential expression in normal tissues for TIMM17B Gene

This gene is overexpressed in Pancreas (16.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM17B Gene

SOURCE GeneReport for Unigene cluster for TIMM17B Gene Hs.30570

mRNA Expression by UniProt/SwissProt for TIMM17B Gene

Tissue specificity: Expression is abundant in heart and skeletal muscle, intermediate in brain, and weak in pancreas, placenta, kidney and liver
genes like me logo Genes that share expressions with TIMM17B: view

Expression partners for TIMM17B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TIMM17B Gene

Orthologs for TIMM17B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIMM17B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIMM17B 35
  • 91.67 (n)
  • 95.35 (a)
TIMM17B 36
  • 95 (a)
(Canis familiaris)
Mammalia TIMM17B 35
  • 92.05 (n)
  • 97.67 (a)
TIMM17B 36
  • 94 (a)
(Mus musculus)
Mammalia Timm17b 35
  • 89.53 (n)
  • 95.93 (a)
Timm17b 16
Timm17b 36
  • 94 (a)
(Pan troglodytes)
Mammalia TIMM17B 35
  • 99.26 (n)
  • 99.44 (a)
TIMM17B 36
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
-- 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia TIMM17B 36
  • 76 (a)
(Anolis carolinensis)
Reptilia TIMM17B 36
  • 83 (a)
(Danio rerio)
Actinopterygii timm17b 35
  • 74.25 (n)
  • 88.62 (a)
timm17b 36
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4689 35
fruit fly
(Drosophila melanogaster)
Insecta CG1724 37
  • 59 (a)
Tim17a1 37
  • 60 (a)
Tim17a2 37
  • 57 (a)
Tim17b1 37
  • 63 (a)
Tim17b2 37
  • 62 (a)
Tim17b 35
  • 62.12 (n)
  • 71.43 (a)
CG1724 36
  • 52 (a)
Tim17a1 36
  • 35 (a)
Tim17a2 36
  • 34 (a)
Tim17b 36
  • 64 (a)
Tim17b1 36
  • 51 (a)
Tim17b2 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004657 35
  • 60.25 (n)
  • 70.81 (a)
(Caenorhabditis elegans)
Secernentea E04A4.5 37
  • 54 (a)
E04A4.5 35
  • 54.88 (n)
  • 56.46 (a)
D2096.1 36
  • 30 (a)
E04A4.5 36
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR248W 35
  • 56 (n)
  • 48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05841g 35
  • 55.26 (n)
  • 51.01 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM17 35
  • 51.21 (n)
  • 49.67 (a)
TIM17 36
  • 46 (a)
TIM17 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TIM17-2 35
  • 56.58 (n)
  • 56.17 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1714 35
(Oryza sativa)
Liliopsida Os.11994 35
Os07g0604500 35
  • 58.73 (n)
  • 57.82 (a)
(Zea mays)
Liliopsida Zm.13937 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05623 35
  • 56.6 (n)
  • 50.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tim17 35
  • 52.7 (n)
  • 48.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4827 36
  • 51 (a)
Species with no ortholog for TIMM17B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TIMM17B Gene

Gene Tree for TIMM17B (if available)
Gene Tree for TIMM17B (if available)

Paralogs for TIMM17B Gene

Paralogs for TIMM17B Gene

Selected SIMAP similar genes for TIMM17B Gene using alignment to 5 proteins: Pseudogenes for TIMM17B Gene

genes like me logo Genes that share paralogs with TIMM17B: view

Variants for TIMM17B Gene

Sequence variations from dbSNP and Humsavar for TIMM17B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1080116 -- 48,894,819(+) cacta(G/T)cccaa intron-variant
rs1080117 -- 48,894,921(+) CCCTA(G/T)AAAGT intron-variant
rs1128363 -- 48,894,188(-) ACCAT(C/T)GACTG reference, synonymous-codon
rs2016813 -- 48,894,759(+) ATGAA(A/G)TGGTT intron-variant
rs2075838 -- 48,893,159(+) GGTCA(A/G)GGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TIMM17B Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Relevant External Links for TIMM17B Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM17B Gene

Disorders for TIMM17B Gene

No disorders were found for TIMM17B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TIMM17B Gene

Publications for TIMM17B Gene

  1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PMID: 10339406) Bauer M.F. … Hofmann S. (J. Mol. Biol. 1999) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for TIMM17B Gene

Sources for TIMM17B Gene

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