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Aliases for TIMM17A Gene

Aliases for TIMM17A Gene

  • Translocase Of Inner Mitochondrial Membrane 17A 2 3 5
  • Inner Membrane Preprotein Translocase Tim17a 3 4
  • TIM17A 3 4
  • TIM17 3 4
  • Translocase Of Inner Mitochondrial Membrane 17 Homolog A (Yeast) 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim17-A 3
  • Translocase Of Inner Mitochondrial Membrane 17 Homolog A 3
  • Mitochondrial Inner Membrane Translocase 3
  • Preprotein Translocase 3
  • MIMT17 4
  • TIMM17 4

External Ids for TIMM17A Gene

Previous GeneCards Identifiers for TIMM17A Gene

  • GC01P199608
  • GC01P197358
  • GC01P198391
  • GC01P199212
  • GC01P198656
  • GC01P200192
  • GC01P173090

Summaries for TIMM17A Gene

GeneCards Summary for TIMM17A Gene

TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM17B.

UniProtKB/Swiss-Prot for TIMM17A Gene

  • Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Gene Wiki entry for TIMM17A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM17A Gene

Genomics for TIMM17A Gene

Regulatory Elements for TIMM17A Gene

Enhancers for TIMM17A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G201954 1.2 ENCODE 21.6 +0.0 30 2.5 MLX CREB3L1 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 MCM3 SP3 TIMM17A IPO9 RNPEP IPO9-AS1 ARL8A GPR37L1 ENSG00000273478 RPS27P8 GC01P201984
GH01G202103 2 FANTOM5 Ensembl ENCODE dbSUPER 10 +151.5 151457 6.6 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZBTB7B YY1 ZNF766 FOS KLF13 ELF3 ENSG00000249007 ELF3-AS1 TIMM17A GPR37L1 PTPRVP LGR6 PPP1R12B CRIP1P3
GH01G201911 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -39.9 -39903 7.6 HDGF FOXA2 SIN3A FEZF1 YY1 ZNF766 FOS KLF13 DEK ZNF263 SHISA4 LMOD1 ENSG00000223774 ARL8A ENSG00000206637 RPL10P4 RNPEP GPR37L1 TIMM17A ENSG00000235121
GH01G201894 1.6 Ensembl ENCODE dbSUPER 11.6 -59.0 -59013 4.1 HDGF ARNT ARID4B ZNF2 ZNF143 FOS DEK ZNF263 PAF1 JUNB LMOD1 IPO9 IPO9-AS1 TIMM17A ENSG00000223774 GC01M201886
GH01G201999 1.1 ENCODE dbSUPER 10.9 +44.3 44297 0.2 CTCF PKNOX1 CBX3 SIN3A ZNF2 THRB RAD21 ZBTB48 POLR2A SCRT2 LMOD1 GPR37L1 TIMM17A ARL8A PTPN7 MIR6740 ENSG00000273478
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIMM17A on UCSC Golden Path with GeneCards custom track

Promoters for TIMM17A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018214 -90 2000 MLX CREB3L1 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 MCM3 SP3

Genomic Location for TIMM17A Gene

Chromosome:
1
Start:
201,955,491 bp from pter
End:
201,970,661 bp from pter
Size:
15,171 bases
Orientation:
Plus strand

Genomic View for TIMM17A Gene

Genes around TIMM17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM17A Gene

Proteins for TIMM17A Gene

  • Protein details for TIMM17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99595-TI17A_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim17-A
    Protein Accession:
    Q99595
    Secondary Accessions:
    • B2RDM5
    • Q9BWF5

    Protein attributes for TIMM17A Gene

    Size:
    171 amino acids
    Molecular mass:
    18024 Da
    Quaternary structure:
    • Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.

neXtProt entry for TIMM17A Gene

Post-translational modifications for TIMM17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM17A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM17A Gene

Domains & Families for TIMM17A Gene

Suggested Antigen Peptide Sequences for TIMM17A Gene

Graphical View of Domain Structure for InterPro Entry

Q99595

UniProtKB/Swiss-Prot:

TI17A_HUMAN :
  • Belongs to the Tim17/Tim22/Tim23 family.
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM17A: view

No data available for Gene Families for TIMM17A Gene

Function for TIMM17A Gene

Molecular function for TIMM17A Gene

UniProtKB/Swiss-Prot Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Gene Ontology (GO) - Molecular Function for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015266 contributes_to protein channel activity IBA --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TIMM17A: view
genes like me logo Genes that share phenotypes with TIMM17A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM17A Gene

Localization for TIMM17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM17A Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM17A gene
Compartment Confidence
mitochondrion 5
nucleus 4
plasma membrane 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IDA 20053669
GO:0005744 mitochondrial inner membrane presequence translocase complex IDA 10339406
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TIMM17A: view

Pathways & Interactions for TIMM17A Gene

genes like me logo Genes that share pathways with TIMM17A: view

Pathways by source for TIMM17A Gene

2 Reactome pathways for TIMM17A Gene

Gene Ontology (GO) - Biological Process for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 10339406
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0030150 protein import into mitochondrial matrix IBA --
genes like me logo Genes that share ontologies with TIMM17A: view

No data available for SIGNOR curated interactions for TIMM17A Gene

Drugs & Compounds for TIMM17A Gene

(1) Drugs for TIMM17A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TIMM17A: view

Transcripts for TIMM17A Gene

Unigene Clusters for TIMM17A Gene

Translocase of inner mitochondrial membrane 17 homolog A (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM17A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: - -

Relevant External Links for TIMM17A Gene

GeneLoc Exon Structure for
TIMM17A
ECgene alternative splicing isoforms for
TIMM17A

Expression for TIMM17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM17A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIMM17A Gene

This gene is overexpressed in Fetal Brain (37.3), Stomach (21.8), and Placenta (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM17A Gene



Protein tissue co-expression partners for TIMM17A Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMM17A Gene:

TIMM17A

SOURCE GeneReport for Unigene cluster for TIMM17A Gene:

Hs.20716

Evidence on tissue expression from TISSUES for TIMM17A Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Bone marrow(4.3)
  • Muscle(4.3)
  • Kidney(2.9)
  • Liver(2.5)
genes like me logo Genes that share expression patterns with TIMM17A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM17A Gene

Orthologs for TIMM17A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIMM17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM17A 34 35
  • 98.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM17A 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM17A 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM17A 34 35
  • 95.13 (n)
rat
(Rattus norvegicus)
Mammalia Timm17a 34
  • 90.06 (n)
mouse
(Mus musculus)
Mammalia Timm17a 34 16 35
  • 89.08 (n)
cow
(Bos Taurus)
Mammalia TIMM17A 34 35
  • 87.13 (n)
chicken
(Gallus gallus)
Aves TIMM17A 34 35
  • 79.92 (n)
lizard
(Anolis carolinensis)
Reptilia TIMM17A 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timm17a 34
  • 72.85 (n)
Str.10877 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.30296 34
zebrafish
(Danio rerio)
Actinopterygii timm17a 34 35
  • 77.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tim17b1 36 35
  • 65 (a)
Tim17b 35
  • 65 (a)
ManyToMany
Tim17a1 36 35
  • 59 (a)
Tim17b2 36 35
  • 59 (a)
CG1724 36 35
  • 57 (a)
Tim17a2 36 35
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea E04A4.5 36 35
  • 50 (a)
D2096.1 35
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM17 35
  • 47 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0415500 34
  • 54.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4827 35
  • 51 (a)
OneToMany
Species where no ortholog for TIMM17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM17A Gene

ENSEMBL:
Gene Tree for TIMM17A (if available)
TreeFam:
Gene Tree for TIMM17A (if available)

Paralogs for TIMM17A Gene

Paralogs for TIMM17A Gene

(2) SIMAP similar genes for TIMM17A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TIMM17A Gene

genes like me logo Genes that share paralogs with TIMM17A: view

Variants for TIMM17A Gene

Sequence variations from dbSNP and Humsavar for TIMM17A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000131923 -- 201,953,550(+) TCTTC(A/G)GTGCT upstream-variant-2KB
rs1000185883 -- 201,960,545(+) GTGGT(G/T)ATATG intron-variant
rs1000295142 -- 201,966,719(+) CGCCT(A/G)TAATC intron-variant
rs1000328603 -- 201,964,969(+) TTTCT(A/T)GAGAC intron-variant
rs1000398304 -- 201,964,816(+) GCTAA(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM17A Gene

Variant ID Type Subtype PubMed ID
nsv1121787 CNV deletion 24896259
nsv161136 CNV deletion 16902084
nsv478856 CNV novel sequence insertion 20440878
nsv946576 CNV duplication 23825009

Variation tolerance for TIMM17A Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM17A Gene

Disorders for TIMM17A Gene

Relevant External Links for TIMM17A

Genetic Association Database (GAD)
TIMM17A
Human Genome Epidemiology (HuGE) Navigator
TIMM17A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM17A

No disorders were found for TIMM17A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM17A Gene

Publications for TIMM17A Gene

  1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PMID: 10339406) Bauer M.F. … Hofmann S. (J. Mol. Biol. 1999) 2 3 4 22 64
  2. The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. (PMID: 8893850) Boemer U. … Maarse A.C. (J. Mol. Biol. 1996) 2 3 4 22 64
  3. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. (PMID: 23263864) Schusdziarra C. … Hell K. (Hum. Mol. Genet. 2013) 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TIMM17A Gene

Sources for TIMM17A Gene

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