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Aliases for TIMM17A Gene

Aliases for TIMM17A Gene

  • Translocase Of Inner Mitochondrial Membrane 17 Homolog A (Yeast) 2 3
  • TIM17A 3 4 6
  • Inner Membrane Preprotein Translocase Tim17a 3 4
  • TIM17 3 4
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim17-A 3
  • Mitochondrial Inner Membrane Translocase 3
  • Preprotein Translocase 3
  • MIMT17 4
  • TIMM17 4

External Ids for TIMM17A Gene

Summaries for TIMM17A Gene

GeneCards Summary for TIMM17A Gene

TIMM17A (Translocase Of Inner Mitochondrial Membrane 17 Homolog A (Yeast)) is a Protein Coding gene. Diseases associated with TIMM17A include barth syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM17B.

UniProtKB/Swiss-Prot for TIMM17A Gene

  • Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane

Gene Wiki entry for TIMM17A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM17A Gene

Genomics for TIMM17A Gene

Genomic Location for TIMM17A Gene

Start:
201,955,491 bp from pter
End:
201,970,661 bp from pter
Size:
15,171 bases
Orientation:
Plus strand

Genomic View for TIMM17A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM17A Gene

Regulatory Elements for TIMM17A Gene

Proteins for TIMM17A Gene

  • Protein details for TIMM17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99595-TI17A_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim17-A
    Protein Accession:
    Q99595
    Secondary Accessions:
    • B2RDM5
    • Q9BWF5

    Protein attributes for TIMM17A Gene

    Size:
    171 amino acids
    Molecular mass:
    18024 Da
    Quaternary structure:
    • Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.

neXtProt entry for TIMM17A Gene

Proteomics data for TIMM17A Gene at MOPED

Post-translational modifications for TIMM17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM17A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM17A Gene

Domains for TIMM17A Gene

Protein Domains for TIMM17A Gene

UniProtKB/Swiss-Prot:

TI17A_HUMAN
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.:
    • Q99595
genes like me logo Genes that share domains with TIMM17A: view

No data available for Gene Families for TIMM17A Gene

Function for TIMM17A Gene

Molecular function for TIMM17A Gene

UniProtKB/Swiss-Prot Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane

Gene Ontology (GO) - Molecular Function for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TIMM17A: view

Phenotypes for TIMM17A Gene

genes like me logo Genes that share phenotypes with TIMM17A: view

miRNA for TIMM17A Gene

miRTarBase miRNAs that target TIMM17A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIMM17A Gene

Localization for TIMM17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM17A Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM17A Gene COMPARTMENTS Subcellular localization image for TIMM17A gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IDA 20053669
GO:0005744 mitochondrial inner membrane presequence translocase complex IDA 10339406
GO:0031305 integral component of mitochondrial inner membrane IDA 10339406
genes like me logo Genes that share ontologies with TIMM17A: view

Pathways for TIMM17A Gene

genes like me logo Genes that share pathways with TIMM17A: view

Pathways by source for TIMM17A Gene

2 Reactome pathways for TIMM17A Gene

Gene Ontology (GO) - Biological Process for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006886 intracellular protein transport --
GO:0044267 cellular protein metabolic process TAS --
GO:0071806 protein transmembrane transport IEA --
genes like me logo Genes that share ontologies with TIMM17A: view

Compounds for TIMM17A Gene

(1) Novoseek inferred chemical compound relationships for TIMM17A Gene

Compound -log(P) Hits PubMed IDs
atp 40.8 2
genes like me logo Genes that share compounds with TIMM17A: view

Transcripts for TIMM17A Gene

mRNA/cDNA for TIMM17A Gene

Unigene Clusters for TIMM17A Gene

Translocase of inner mitochondrial membrane 17 homolog A (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM17A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: - -

Relevant External Links for TIMM17A Gene

GeneLoc Exon Structure for
TIMM17A
ECgene alternative splicing isoforms for
TIMM17A

Expression for TIMM17A Gene

mRNA expression in normal human tissues for TIMM17A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM17A Gene

SOURCE GeneReport for Unigene cluster for TIMM17A Gene Hs.20716

genes like me logo Genes that share expressions with TIMM17A: view

Orthologs for TIMM17A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIMM17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM17A 36
  • 98.83 (n)
  • 97.66 (a)
TIMM17A 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIMM17A 36
  • 87.13 (n)
  • 95.91 (a)
TIMM17A 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM17A 36
  • 95.13 (n)
  • 99.42 (a)
TIMM17A 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm17a 36
  • 89.08 (n)
  • 95.91 (a)
Timm17a 16
Timm17a 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM17A 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM17A 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm17a 36
  • 90.06 (n)
  • 96.49 (a)
chicken
(Gallus gallus)
Aves TIMM17A 36
  • 79.92 (n)
  • 93.37 (a)
TIMM17A 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIMM17A 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30296 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10877 36
timm17a 36
  • 72.85 (n)
  • 83.83 (a)
zebrafish
(Danio rerio)
Actinopterygii timm17a 36
  • 77.31 (n)
  • 89.16 (a)
timm17a 37
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1724 37
  • 52 (a)
ManyToMany
Tim17a1 37
  • 38 (a)
ManyToMany
Tim17a2 37
  • 35 (a)
ManyToMany
Tim17b 37
  • 65 (a)
ManyToMany
Tim17b1 37
  • 49 (a)
ManyToMany
Tim17b2 37
  • 56 (a)
ManyToMany
Tim17a2 38
  • 57 (a)
Tim17b2 38
  • 59 (a)
CG1724 38
  • 57 (a)
Tim17a1 38
  • 59 (a)
Tim17b1 38
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea D2096.1 37
  • 26 (a)
ManyToMany
E04A4.5 37
  • 43 (a)
ManyToMany
E04A4.5 38
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM17 37
  • 47 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0415500 36
  • 54.64 (n)
  • 59.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4827 37
  • 51 (a)
OneToMany
Species with no ortholog for TIMM17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM17A Gene

ENSEMBL:
Gene Tree for TIMM17A (if available)
TreeFam:
Gene Tree for TIMM17A (if available)

Paralogs for TIMM17A Gene

Paralogs for TIMM17A Gene

Selected SIMAP similar genes for TIMM17A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TIMM17A Gene

genes like me logo Genes that share paralogs with TIMM17A: view

Variants for TIMM17A Gene

Sequence variations from dbSNP and Humsavar for TIMM17A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4648 - 201,965,450(+) CCATG(A/G)TTGGG missense, reference
rs7513 -- 201,969,867(-) AAGGA(A/G)ATGAT utr-variant-3-prime
rs1045893 -- 201,970,624(+) ATTTT(C/T)GACTG utr-variant-3-prime
rs1128660 -- 201,970,225(+) ATTTC(A/C)CCAGA utr-variant-3-prime
rs1128672 -- 201,970,290(+) CTGGC(A/C)CTGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIMM17A Gene

Variant ID Type Subtype PubMed ID
nsv161136 CNV Loss 16902084

Relevant External Links for TIMM17A Gene

HapMap Linkage Disequilibrium report
TIMM17A

Disorders for TIMM17A Gene

(1) MalaCards Diseases for TIMM17A Gene

Search for TIMM17A Gene in MalaCards »

(1) Novoseek inferred disease relationships for TIMM17A Gene

Disease -log(P) Hits PubMed IDs
shock 0 1

Relevant External Links for TIMM17A

Genetic Association Database (GAD)
TIMM17A
Human Genome Epidemiology (HuGE) Navigator
TIMM17A
genes like me logo Genes that share disorders with TIMM17A: view

No data available for UniProtKB/Swiss-Prot for TIMM17A Gene

Publications for TIMM17A Gene

  1. The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. (PMID: 8893850) Boemer U. … Maarse A.C. (J. Mol. Biol. 1996) 2 3 4 23
  2. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PMID: 10339406) Bauer M.F. … Hofmann S. (J. Mol. Biol. 1999) 2 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for TIMM17A Gene

Sources for TIMM17A Gene

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