Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMM17A Gene

protein-coding   GIFtS: 60
GCID: GC01P201924

translocase of inner mitochondrial membrane 17 homolog A...
 Explore 4 diseases affiliated with
TIMM17A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TIMM17A    

Aliases
for TIMM17A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Translocase Of Inner Mitochondrial Membrane 17 Homolog A (Yeast)1 2     Mitochondrial Inner Membrane Translocase2
TIM17A1 2 3 5     Preprotein Translocase2
TIM171 2 3     MIMT173
Inner Membrane Preprotein Translocase Tim17a2 3     TIMM173
Mitochondrial Import Inner Membrane Translocase Subunit Tim17-A2     

External Ids:    HGNC: 173151   Entrez Gene: 104402   Ensembl: ENSG000001343757   OMIM: 6050575   UniProtKB: Q995953   

Export aliases for TIMM17A gene to outside databases

Previous GC identifers: GC01P199608 GC01P197358 GC01P198391 GC01P199212 GC01P198656 GC01P200192 GC01P173090


Summaries
for TIMM17A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TI17A_HUMAN, Q99595
Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit
peptide-containing proteins across the mitochondrial inner membrane

Gene Wiki entry for TIMM17A


Genomic Views
for TIMM17A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMM17A gene promoter:
         AML1a   HTF   LUN-1   Evi-1   E47   POU2F1   POU2F1a   FOXO4   Hand1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIMM17A promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMM17A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM17A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

TIMM17A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM17A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P201924:  view genomic region     (about GC identifiers)

Start:
 201,924,619 bp from pter      End:
 201,939,789 bp from pter
Size:
 15,171 bases      Orientation:
 plus strand

Proteins
for TIMM17A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TI17A_HUMAN, Q99595 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim17-A  
Size: 171 amino acids; 18024 Da
Subunit: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The
complex interacts with the TIMM44 component of the PAM complex
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: B2RDM5 Q9BWF5

Explore the universe of human proteins at neXtProt for TIMM17A: NX_Q99595

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99595

    • TIMM17A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006326.1  
    ENSEMBL proteins: 
     ENSP00000356256  
    Reactome Protein details: Q99595
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TIMM17A
    OriGene Custom Protein Services for TIMM17A 
    GenScript Custom Purified and Recombinant Proteins Services for TIMM17A
    Novus Biologicals TIMM17A Protein
    Novus Biologicals TIMM17A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TIMM17A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane ----
    GO:0005744mitochondrial inner membrane presequence translocase complex IDA10339406
    GO:0031305integral to mitochondrial inner membrane IDA10339406


    TIMM17A for ontologies           About GeneDecksing



    TIMM17A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: TIMM17A
    OriGene Custom Antibody Services for TIMM17A 
    GenScript Custom Superior Antibodies Services for TIMM17A
    Novus Biologicals TIMM17A Antibodies
    Search for Antibodies for TIMM17A at Abcam  
    Uscn Antibodies for TIMM17A
    ThermoFisher Antibodies for TIMM17A

    Assay Products for TIMM17A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIMM17A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TIMM17A

    Protein Domains /
    Families
    for TIMM17A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TIMM17A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003397 Tim17/Tim22/Tim23/PMP24
     IPR005678 Tim17

    Graphical View of Domain Structure for InterPro Entry Q99595

    ProtoNet protein and cluster: Q99595

    1 Blocks protein family: IPB003397 Mitochondrial import inner membrane translocase

    UniProtKB/Swiss-Prot: TI17A_HUMAN, Q99595
    Similarity: Belongs to the Tim17/Tim22/Tim23 family


    Function
    for TIMM17A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TI17A_HUMAN, Q99595
    Function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit
    peptide-containing proteins across the mitochondrial inner membrane

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TIMM17A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM17A
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM17A (see all 32):
    hsa-miR-548j hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-105 hsa-miR-133a hsa-miR-93 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TIMM17A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM17A (see all 7)
    OriGene shRNA RFP: TIMM17A
    OriGene siRNA: TIMM17A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM17A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TIMM17A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM17A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM17A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMM17A (NM_006335)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM17A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM17A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TIMM17A
    Search LifeMap BioReagents cell lines for TIMM17A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM17A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA--


    TIMM17A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TIMM17A:
     Decreased TP53 protein express 


    Pathways & Interactions
    for TIMM17A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Protein Import
    		Mitochondrial Protein Import1.00
    2Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for TIMM17A
        Mitochondrial Protein Import
    Metabolism of proteins



    TIMM17A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIMM17A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for TIMM17A (Q995952, 3 ENSP000003562564) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAP1P542572, 3, ENSP000003340024MINT-65283 I2D: score=3 STRING: ENSP00000334002
    TUBA1AQ71U362, 3, ENSP000003010714MINT-8272773 I2D: score=2 STRING: ENSP00000301071
    TIMM44O436153, ENSP000002705384I2D: score=3 STRING: ENSP00000270538
    DNAJC19Q96DA63, ENSP000003720054I2D: score=1 STRING: ENSP00000372005
    TIMM23O149253, ENSP000002608674I2D: score=1 STRING: ENSP00000260867
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0044267cellular protein metabolic process TAS--


    TIMM17A for ontologies           About GeneDecksing



    Drugs & Compounds
    for TIMM17A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIMM17A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMM17A
    1 Novoseek chemical compound relationship for TIMM17A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 40.8 2 1825804 (1), 8940175 (1)

    Search CenterWatch for drugs/clinical trials and news about TIMM17A / TI17A 

    Transcripts
    for TIMM17A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TIMM17A gene: 
    NM_006335.2  

    Unigene Cluster for TIMM17A:

    Translocase of inner mitochondrial membrane 17 homolog A (yeast)
    Hs.20716  [show with all ESTs]
    Unigene Representative Sequence: AK023063
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367287(uc001gxc.3) ENST00000478378 ENST00000484647 ENST00000482943


    miRNA
    Products:             		 OriGene 3'-UTR Clone: TIMM17A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM17A
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM17A (see all 32):
    hsa-miR-548j hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-105 hsa-miR-133a hsa-miR-93 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TIMM17A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM17A (see all 7)
    OriGene shRNA RFP: TIMM17A
    OriGene siRNA: TIMM17A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM17A
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM17A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM17A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMM17A (NM_006335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM17A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM17A 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM17A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM17A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM17A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM17A

    Additional cDNA sequence: 

    AF106622.1 AK023063.1 AK315602.1 BC000294.2 BC004439.1 BC007106.1 BC009784.1 BC013823.1 
    BC015098.1 BC016817.1 BC020833.1 X97544.1 

    19 DOTS entries:

    DT.446478  DT.100845287  DT.419417  DT.100845289  DT.100845286  DT.100845282  DT.100845284  DT.100845290 
    DT.121462464  DT.91964004  DT.121462415  DT.121462458  DT.91650679  DT.91773291  DT.91773292  DT.95127417 
    DT.95258963  DT.121462468  DT.95148692 

    24/582 AceView cDNA sequences (see all 582):

    CB153671 BI908236 AW245166 BE958021 AA521329 BP357901 AW969073 BU162311 
    CD369048 N74521 CB144069 AI492287 BC013823 BU624425 AI242933 BQ441111 
    AI277528 AA889299 BE550142 CB528493 AW168033 CB132495 AU104743 CB131897 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM17A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                                            
    SP2:                          -                                 
    SP3:                          -     -                           


    ECgene alternative splicing isoforms for TIMM17A

    Expression
    for TIMM17A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMM17A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAGTGTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TIMM17A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TIMM17A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMM17A

    SOURCE GeneReport for Unigene cluster: Hs.20716
        SABiosciences Expression via Pathway-Focused PCR Array including TIMM17A: 
              Mitochondria in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM17A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM17A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM17A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM17A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM17A

    Orthologs
    for TIMM17A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TIMM17A gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TIMM17A1 translocase of inner mitochondrial membrane 17 homolog more 79.92(n)
    93.37(a)    		   421147  NM_001031026.1  NP_001026197.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TIMM17A6
    		 --
    		 94(a)
    		 1 ↔ 1
    		 4(133580575-133589639)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.302962 Xenopus laevis transcribed sequence with moderate similarity more 76.94(n)    BJ625546.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii timm17a2 translocase of inner mitochondrial membrane 17 homolog more 79.12(n)   386636  BC056525.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tim17b13
    CG17241    		 protein transport protein translocase3
    CG17241    		 65(a)
    (best of 5)3
    60.84(n)1
    63.64(a)1    		   82F93
    330971  NM_134595.31  NP_608439.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea E04A4.53   -- 50(a)   IV(4744699-4745784)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TIM17-21 mitochondrial import inner membrane translocase subunit more 59.03(n)
    59.54(a)    		   818317  NM_129296.3  NP_181277.1 
    rice
    (Oryza sativa)    		 Liliopsida Os07g06045001 hypothetical protein 53.6(n)
    57.43(a)    		   4343846  NM_001066756.1  NP_001060221.1 


    ENSEMBL Gene Tree for TIMM17A (if available)
    TreeFam Gene Tree for TIMM17A (if available) 

    Paralogs
    for TIMM17A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMM17A gene
    TIMM17B2  
    2 SIMAP similar genes for TIMM17A using alignment to 2 protein entries:     TI17A_HUMAN (see all proteins):
    TIM17A    TIMM17B

    TIMM17A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TIMM17A
    PGOHUM00000245138


    Genomic Variants
    for TIMM17A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/312 NCBI SNPs in TIMM17A are shown (see all 312)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs174734341,2
    		C,F,H,--201922759(+) ACAATT/CAAATA 1 -- us2k124Minor allele frequency- C:0.21NA NS EA WA CSA 2490
    rs1815807571,2
    		--201922881(+) TAATCA/TTTAGT 1 -- us2k10--------
    rs1415451361,2
    		--201923165(+) GTCTCA/GAACTC 1 -- us2k10--------
    rs120490251,2
    		--201923178(+) GACCTC/TGTGAT 1 -- us2k10--------
    rs1858391831,2
    		--201923347(+) GCCATC/TACATG 1 -- us2k10--------
    rs49507441,2
    		C,F,H,--201923383(+) AAAAGC/TTCCAT 1 -- us2k120Minor allele frequency- T:0.20NA NS EA WA 2478
    rs28203051,2
    		C,F,A,H,--201923481(+) TAGATC/TTCCTG 1 -- us2k110Minor allele frequency- T:0.32NS EA NA WA CSA 774
    rs1379468561,2
    		--201923583(+) TTCTCC/TGAGCC 1 -- us2k10--------
    rs745575431,2
    		--201923635(+) TGTGAA/GAGGCT 1 -- us2k10--------
    rs28203061,2
    		C,F,O,A,H,--201923805(+) CGTGTA/GTTTGG 1 -- us2k124Minor allele frequency- G:0.34EA NA MN NS WA CSA 2624

    HapMap Linkage Disequilibrium report for TIMM17A (201924619 - 201939789 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TIMM17A
         1 CNV: 5544

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM17A
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM17A

    Disorders / Diseases
    for TIMM17A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TIMM17A for disorders           About GeneDecksing

    OMIM gene information: 605057    OMIM disorders: --

    4 diseases for TIMM17A:    About MalaCards
    barth syndrome    twinning    breast cancer    malaria

    1 Novoseek disease relationship for TIMM17A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 0 1 9442867 (1)

    Human Genome Epidemiology (HuGE) Navigator: TIMM17A (1 document)

    Export disorders for TIMM17A gene to outside databases

    Publications
    for TIMM17A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMM17A gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with TIMM17A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PubMed id 10339406)1, 2, 3, 9 Bauer M.F.... Hofmann S. (1999)
    2. The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. (PubMed id 8893850)1, 2, 3, 9 Boemer U.... Maarse A.C. (1996)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. (PubMed id 10393182)1, 9 Moro F....Brunner M. (1999)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. High TIMM17A expression is associated with adverse pat hological and clinical outcomes in human breast cancer. (PubMed id 20972741)1 Salhab M....Mokbel K. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for TIMM17A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TIMM17A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10440 HGNC: 17315 AceView: TIMM17A Ensembl:ENSG00000134375 euGenes: HUgn10440
    ECgene: TIMM17A H-InvDB: TIMM17A

    Other Databases showing TIMM17A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TIMM17A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMM17A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM17A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TIMM17A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TIMM17A gene:
    Search GeneIP for patents involving TIMM17A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TIMM17A gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TIMM17A   OriGene shRNA RFP for TIMM17A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM17A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM17A  
     OriGene Protein Over-expression Lysate for TIMM17A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TIMM17A   OriGene 3'-UTR Clone for TIMM17A  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM17A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM17A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TIMM17A   OriGene Custom Protein Services for TIMM17A  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMM17A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM17A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM17A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM17A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM17A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM17A
     GenScript Custom Purified and Recombinant Proteins Services for TIMM17A GenScript cDNA clones with any tag delivered in your preferred vector for TIMM17A
     GenScript Custom Assay Services for TIMM17A GenScript Custom Superior Antibodies Services for TIMM17A
     GenScript Custom overexpressing Cell Line Services for TIMM17A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TIMM17A promoter
     Search Chromatin IP Primers for TIMM17A
     RT2 qPCR Primer Assay in human, mouse, rat TIMM17A
     Search GNC Networks for TIMM17A
     SABiosciences PCR Arrays including human, mouse, rat TIMM17A
     Search Tocris compounds for TIMM17A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TIMM17A antibodies
     TIMM17A proteins
     TIMM17A lysates
     Search for Antibodies for TIMM17A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TIMM17A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TIMM17A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TIMM17A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM17A
     SwitchGear 3'UTR luciferase reporter plasmids for TIMM17A
     SwitchGear Promoter luciferase reporter plasmids for TIMM17A
     ThermoFisher Antibodies for TIMM17A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM17A
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TIMM17A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4