Aliases for TIMM13 Gene
External Ids for TIMM13 Gene
Previous HGNC Symbols for TIMM13 Gene
Previous GeneCards Identifiers for TIMM13 Gene
This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013]
GeneCards Summary for TIMM13 Gene
TIMM13 (Translocase Of Inner Mitochondrial Membrane 13) is a Protein Coding gene. Diseases associated with TIMM13 include Mohr-Tranebjaerg Syndrome and Mitochondrial Metabolism Disease. Among its related pathways are Mitochondrial protein import and Metabolism of proteins.
UniProtKB/Swiss-Prot for TIMM13 Gene
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins.