Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMM13 Gene

protein-coding   GIFtS: 54
GCID: GC19M002425

translocase of inner mitochondrial membrane 13 homolog (yeast)

(Previous name: translocase of inner mitochondrial membrane 13 (yeast)...)
(Previous symbol: TIMM13B)
 Explore 6 diseases affiliated with
TIMM13 via our new
 Human Malady Compendium 
Biological research products
for TIMM13
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Translocase Of Inner Mitochondrial Membrane 13 Homolog (Yeast)1 2     Translocase Of Inner Mitochondrial Membrane 13 (Yeast) Homolog B1
TIMM13B1 2 3     TIM132
TIM13B2 3     Mitochondrial Import Inner Membrane Translocase Subunit Tim132
TIMM13A2 3     Mitochondrial Import Inner Membrane Translocase Subunit Tim13B2
Tim131     Ppv11

External Ids:    HGNC: 118161   Entrez Gene: 265172   Ensembl: ENSG000000998007   OMIM: 6073835   UniProtKB: Q9Y5L43   

Export aliases for TIMM13 gene to outside databases

Previous GC identifers: GC19M002488 GC19M002365 GC19M002376 GC19M002197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIMM13:
This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of
metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the
TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the
gene for lamin B2. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIM13_HUMAN, Q9Y5L4
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass
transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors
from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a
chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the
mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23,
SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much
more proteins

Gene Wiki entry for TIMM13


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMM13 gene promoter:
         AhR   p53   HNF-4alpha2   Nkx2-5   Tal-1beta   LCR-F1   YY1   HNF-4alpha1   HEN1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM13 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMM13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TIMM13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM13 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002425:  view genomic region     (about GC identifiers)

Start:
2,425,622 bp from pter      End:
2,427,892 bp from pter
Size:
2,271 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIM13_HUMAN, Q9Y5L4 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim13  
Size: 95 amino acids; 10500 Da
Subunit: Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa
complex. Associates with the TIM22 complex, whose core is composed of TIMM22
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
Secondary accessions: P62206 Q9UHL8 Q9WTL1

Explore the universe of human proteins at neXtProt for TIMM13: NX_Q9Y5L4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5L4

  • TIMM13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036590.1  
    ENSEMBL proteins: 
     ENSP00000215570   ENSP00000464881  
    Reactome Protein details: Q9Y5L4
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TIMM13
    OriGene Protein Over-expression Lysate: TIMM13
    OriGene Custom Protein Services for TIMM13 
    GenScript Custom Purified and Recombinant Proteins Services for TIMM13
    Novus Biologicals TIMM13 Protein
    Novus Biologicals TIMM13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TIMM13

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0042719mitochondrial intermembrane space protein transporter complex TAS10552927


    TIMM13 for ontologies           About GeneDecksing



    TIMM13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TIMM13 
    GenScript Custom Superior Antibodies Services for TIMM13
    Novus Biologicals TIMM13 Antibodies
    Search for Antibodies for TIMM13 at Abcam  
    Uscn Antibodies for TIMM13
    Search ThermoFisher Antibodies for TIMM13

    Assay Products for TIMM13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIMM13
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TIMM13


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TIMM13 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004217 zf-Tim10_DDP

    Graphical View of Domain Structure for InterPro Entry Q9Y5L4

    ProtoNet protein and cluster: Q9Y5L4

    1 Blocks protein family: IPB004217 Zn-finger

    UniProtKB/Swiss-Prot: TIM13_HUMAN, Q9Y5L4
    Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial
    intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues
    probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By
    similarity)
    Similarity: Belongs to the small Tim family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TIM13_HUMAN, Q9Y5L4
    Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass
    transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors
    from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a
    chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the
    mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23,
    SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much
    more proteins

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: TIMM13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TIMM13:
    hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTIMM13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM13 (see all 7)
    OriGene shRNA RFP: TIMM13
    OriGene siRNA: TIMM13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMM13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMM13 (NM_012458)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIMM13
    Search LifeMap BioReagents cell lines for TIMM13

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM13

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding TAS10552927


    TIMM13 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TIMM13:
     Increased cell number in G2M,   Large nuclei 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Protein Import
    Mitochondrial Protein Import1.00
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for TIMM13
        Mitochondrial Protein Import
    Metabolism of proteins



    TIMM13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMM13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for TIMM13 (Q9Y5L42, 3 ENSP000002155704) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRM1Q161862, 3, ENSP000002530034MINT-3373592 I2D: score=1 STRING: ENSP00000253003
    TIMM8AO602203, ENSP000003619934I2D: score=3 STRING: ENSP00000361993
    CAB39Q9Y3763, ENSP000002584184I2D: score=2 STRING: ENSP00000258418
    CUL2Q136173, ENSP000003638804I2D: score=2 STRING: ENSP00000363880
    MOB4Q9Y3A33, ENSP000003157024I2D: score=2 STRING: ENSP00000315702
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0007605sensory perception of sound TAS10552927
    GO:0044267cellular protein metabolic process TAS--
    GO:0045039protein import into mitochondrial inner membrane IEA--
    GO:0072321chaperone-mediated protein transport TAS16387659


    TIMM13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMM13
    Search CenterWatch for drugs/clinical trials and news about TIMM13 / TIM13 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMM13 gene: 
    NM_012458.2  

    Unigene Cluster for TIMM13:

    Translocase of inner mitochondrial membrane 13 homolog (yeast)
    Hs.75056  [show with all ESTs]
    Unigene Representative Sequence: NM_012458
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215570(uc002lvx.1) ENST00000591871

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: TIMM13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TIMM13:
    hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTIMM13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM13 (see all 7)
    OriGene shRNA RFP: TIMM13
    OriGene siRNA: TIMM13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM13
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIMM13 (NM_012458)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM13 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM13

    Additional cDNA sequence: 

    AF144700.1 AF152352.1 AK024764.1 BC008607.1 

    22 DOTS entries:

    DT.445441  DT.100814697  DT.100814691  DT.121414517  DT.95092171  DT.121414535  DT.95126398  DT.121414205 
    DT.121414400  DT.121414433  DT.102841016  DT.121414448  DT.121414818  DT.121414227  DT.121414283  DT.121414688 
    DT.121414789  DT.95284371  DT.95296268  DT.99988806  DT.121414602  DT.121414837 

    24/529 AceView cDNA sequences (see all 529):

    BG681234 BU678094 AF152352 NM_032737 AI969544 BM462129 BM924262 BM743145 
    BQ957136 CR599500 BQ232335 BC006551 BM802119 BX462565 AI459075 BM808866 
    AW248577 BM473895 BG169666 BM829797 BM718430 CR621909 BP871275 BE797199 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMM13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACGTACTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TIMM13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMM13

    SOURCE GeneReport for Unigene cluster: Hs.75056

    UniProtKB/Swiss-Prot: TIM13_HUMAN, Q9Y5L4
    Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle

        SABiosciences Custom PCR Arrays for TIMM13
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMM13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TIMM13 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm131 , 5 translocase of inner mitochondrial membrane 13 homolog more5
    translocase of inner mitochondrial membrane 131
    90.53(n)1
    94.74(a)1
      10 (39.72 cM)5
    300551  NM_013895.41  NP_038923.11 
     808994505 
    chicken
    (Gallus gallus)
    Aves LOC1008593521 mitochondrial import inner membrane translocase subunit more 87.72(n)
    94.74(a)
      100859352  XM_003642834.1  XP_003642882.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115332 Xenopus laevis transcribed sequence with strong similarity more 75.75(n)    BJ030242.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd44h112 Transcribed sequence with moderate similarity to protein more 79.12(n)    BI984821.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG341321 CG34132 64.94(n)
    67.53(a)
      4379884  NM_001042879.1  NP_001036344.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tin-136
    Mitochondrial import inner membrane translocase su...
    32(a)
    1 ↔ 1
    I(8759187-8759784)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TIM136
    mitochondrial import inner membrane translocase su...
    41(a)
    1 ↔ 1
    1(22718705-22719516)
    rice
    (Oryza sativa)
    Liliopsida --
    mitochondrial import inner membrane translocase su...
    45(a)
    1 ↔ 1
    2(27903683-27906198)


    ENSEMBL Gene Tree for TIMM13 (if available)
    TreeFam Gene Tree for TIMM13 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMM13 gene
    2 SIMAP similar genes for TIMM13 using alignment to 2 protein entries:     TIM13_HUMAN (see all proteins):
    TIMM8B    TIMM8A

    TIMM13 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TIMM13
    PGOHUM00000250554 PGOHUM00000249657


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 NCBI SNPs in TIMM13 are shown (see all 111    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs621222671,2
    C,--2425294(+) GGTGCG/CGGGCT 2 -- int1 ds50011Minor allele frequency- C:0.50NA 2
    rs1916352721,2
    --2425666(+) TTATTA/GGGCAA 2 -- ut31 int10--------
    rs1852882181,2
    --2425752(+) GACCAC/TGTGGC 2 -- int1 ut310--------
    rs1898754771,2
    --2425770(+) CATAAA/GTGTCT 2 -- ut31 int10--------
    rs2001283151,2
    --2425893(+) ACCGGC/TCTCTG 2 -- ut31 int10--------
    rs2020496011,2
    --2425904(+) AACCCC/TCTTTC 2 -- int1 ut310--------
    rs2021068861,2
    --2426128(+) AAGCAA/GCAGGA 2 -- ut31 ds50010--------
    rs1420885311,2
    --2426168(+) CGTACC/TCTACC 2 -- ut31 ds50010--------
    rs1493801781,2
    --2426185(+) GGTGT-/GGGGGG 2 -- ds5001 ut310--------
    rs1871281431,2
    --2426187(+) GGTGTA/GGGGGG 2 -- ds5001 ut310--------

    HapMap Linkage Disequilibrium report for TIMM13 (2425622 - 2427892 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TIMM13: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM13
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TIMM13 for disorders           About GeneDecksing

    OMIM gene information: 607383    OMIM disorders: --

    6 diseases for TIMM13:    About MalaCards
    mohr-tranebjaerg syndrome    cortical blindness    choledocholithiasis    familial deafness
    blindness    twinning

    2 diseases from the University of Copenhagen DISEASES database for TIMM13:
    Deafness dystonia syndrome     Cortical blindness

    Export disorders for TIMM13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMM13 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with TIMM13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PubMed id 10552927)1, 2, 3 Jin H.... Vetrie D.L.P. (1999)
    2. The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex. (PubMed id 15254020)1, 2, 9 Roesch K.... Koehler C.M. (2004)
    3. Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space. (PubMed id 17329230)1, 3 Gentle I.E....Lithgow T. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PubMed id 11489896)1, 2 Rothbauer U.... Bauer M.F. (2001)
    6. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2 Bauer M.F.... Hofmann S. (1999)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26517 HGNC: 11816 AceView: TIMM13andMKNK2 Ensembl:ENSG00000099800 euGenes: HUgn26517
    ECgene: TIMM13 H-InvDB: TIMM13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMM13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMM13 gene:
    Search GeneIP for patents involving TIMM13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TIMM13  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM13   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM13  
     OriGene Protein Over-expression Lysate for TIMM13   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TIMM13   OriGene 3'-UTR Clone for TIMM13  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM13   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM13  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TIMM13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TIMM13   OriGene Custom Protein Services for TIMM13  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMM13
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM13
     GenScript Custom Purified and Recombinant Proteins Services for TIMM13 GenScript cDNA clones with any tag delivered in your preferred vector for TIMM13
     GenScript Custom Assay Services for TIMM13 GenScript Custom Superior Antibodies Services for TIMM13
     GenScript Custom overexpressing Cell Line Services for TIMM13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TIMM13 promoter
     Search Chromatin IP Primers for TIMM13
     RT2 qPCR Primer Assay in human, mouse, rat TIMM13
     GNC Network for TIMM13
     SABiosciences Custom PCR Arrays for TIMM13
     Search Tocris compounds for TIMM13
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TIMM13 antibodies
     TIMM13 proteins
     TIMM13 lysates
     Search for Antibodies for TIMM13 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TIMM13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TIMM13 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TIMM13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM13
     SwitchGear 3'UTR luciferase reporter plasmids for TIMM13
     SwitchGear Promoter luciferase reporter plasmids for TIMM13
     Search ThermoFisher Antibodies for TIMM13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM13
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TIMM13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4