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Aliases for TIMM10B Gene

Aliases for TIMM10B Gene

  • Translocase Of Inner Mitochondrial Membrane 10 Homolog B (Yeast) 2 3
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim9 B 3 4
  • Fracture Callus Protein 1 3 4
  • TIM10B 3 4
  • Tim9b 3 4
  • FXC1 3 4
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B 3
  • Fracture Callus 1 (Rat) Homolog 2
  • Fracture Callus 1 Homolog (Rat) 2
  • Fracture Callus 1 Homolog 3
  • TIMM9B 4
  • FXC1, 6

External Ids for TIMM10B Gene

Previous HGNC Symbols for TIMM10B Gene

  • FXC1

Summaries for TIMM10B Gene

Entrez Gene Summary for TIMM10B Gene

  • FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

GeneCards Summary for TIMM10B Gene

TIMM10B (Translocase Of Inner Mitochondrial Membrane 10 Homolog B (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import.

UniProtKB/Swiss-Prot for TIMM10B Gene

  • Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Gene Wiki entry for TIMM10B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM10B Gene

Genomics for TIMM10B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIMM10B Gene

Start:
6,481,447 bp from pter
End:
6,484,681 bp from pter
Size:
3,235 bases
Orientation:
Plus strand

Genomic View for TIMM10B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM10B Gene

No data available for Regulatory Elements for TIMM10B Gene

Proteins for TIMM10B Gene

  • Protein details for TIMM10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5J6-T10B_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim10 B
    Protein Accession:
    Q9Y5J6
    Secondary Accessions:
    • Q96FF3

    Protein attributes for TIMM10B Gene

    Size:
    103 amino acids
    Molecular mass:
    11586 Da
    Quaternary structure:
    • Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein TIMM10B/FXC1 and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. Also forms a complex composed of TIMM9, TIMM10/TIM10A and TIMM10B/FXC1

neXtProt entry for TIMM10B Gene

Proteomics data for TIMM10B Gene at MOPED

Post-translational modifications for TIMM10B Gene

No Post-translational modifications

Other Protein References for TIMM10B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM10B Gene

Domains for TIMM10B Gene

Protein Domains for TIMM10B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y5J6

UniProtKB/Swiss-Prot:

T10B_HUMAN :
  • Q9Y5J6
Domain:
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B/FXC1 from the cytoplasm into the mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across the mitochondrial outer membrane (By similarity).
Family:
  • Belongs to the small Tim family.
genes like me logo Genes that share domains with TIMM10B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TIMM10B Gene

Function for TIMM10B Gene

Molecular function for TIMM10B Gene

UniProtKB/Swiss-Prot Function: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Gene Ontology (GO) - Molecular Function for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIMM10B: view

Animal Model Products

CRISPR Products

miRNA for TIMM10B Gene

miRTarBase miRNAs that target TIMM10B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM10B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIMM10B Gene

Localization for TIMM10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM10B Gene

Mitochondrion inner membrane; Peripheral membrane protein.

Gene Ontology (GO) - Cellular Components for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005758 mitochondrial intermembrane space TAS 14726512
GO:0042719 mitochondrial intermembrane space protein transporter complex IDA 14726512
genes like me logo Genes that share ontologies with TIMM10B: view

No data available for Subcellular locations from COMPARTMENTS for TIMM10B Gene

Pathways for TIMM10B Gene

genes like me logo Genes that share pathways with TIMM10B: view

Pathways by source for TIMM10B Gene

2 Reactome pathways for TIMM10B Gene

Gene Ontology (GO) - Biological Process for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0007160 cell-matrix adhesion TAS 9731230
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TIMM10B: view

Transcripts for TIMM10B Gene

Unigene Clusters for TIMM10B Gene

Translocase of inner mitochondrial membrane 10 homolog B (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM10B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for TIMM10B Gene

GeneLoc Exon Structure for
TIMM10B
ECgene alternative splicing isoforms for
TIMM10B

Expression for TIMM10B Gene

mRNA expression in normal human tissues for TIMM10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM10B Gene

SOURCE GeneReport for Unigene cluster for TIMM10B Gene Hs.54943

mRNA Expression by UniProt/SwissProt for TIMM10B Gene

Q9Y5J6-T10B_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
genes like me logo Genes that share expressions with TIMM10B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TIMM10B Gene

Orthologs for TIMM10B Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FXC1 35
  • 99.35 (n)
  • 99.03 (a)
FXC1 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FXC1 35
  • 89.61 (n)
  • 91.4 (a)
FXC1 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
OneToMany
FXC1 35
  • 93.55 (n)
  • 97.85 (a)
mouse
(Mus musculus)
Mammalia Timm10b 35
  • 90.68 (n)
  • 92.47 (a)
Timm10b 16
Timm10b 36
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Timm10b 35
  • 91.4 (n)
  • 94.62 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8097 35
zebrafish
(Danio rerio)
Actinopterygii timm10b 35
  • 63.2 (n)
  • 63.64 (a)
timm10b 36
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tim9b 36
  • 27 (a)
OneToMany
Species with no ortholog for TIMM10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMM10B Gene

ENSEMBL:
Gene Tree for TIMM10B (if available)
TreeFam:
Gene Tree for TIMM10B (if available)

Paralogs for TIMM10B Gene

Selected SIMAP similar genes for TIMM10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TIMM10B: view

No data available for Paralogs for TIMM10B Gene

Variants for TIMM10B Gene

Sequence variations from dbSNP and Humsavar for TIMM10B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1140221 -- 6,484,294(+) TCACT(A/G)TATTG utr-variant-3-prime
rs11040898 -- 6,484,041(+) AGAAT(A/G)TGCCA utr-variant-3-prime
rs34052361 -- 6,484,049(+) CAGAA(-/A)GGCAC utr-variant-3-prime
rs59421287 -- 6,484,239(+) ATGCG(A/C/G)CACCA utr-variant-3-prime
rs73400870 -- 6,484,876(+) TTTCA(A/G)TCTCT downstream-variant-500B

Relevant External Links for TIMM10B Gene

HapMap Linkage Disequilibrium report
TIMM10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIMM10B Gene

Disorders for TIMM10B Gene

No disorders were found for TIMM10B Gene.

No data available for UniProtKB/Swiss-Prot for TIMM10B Gene

Publications for TIMM10B Gene

  1. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PMID: 10552927) Jin H. … Vetrie D.L.P. (Genomics 1999) 2 3 4
  2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer M.F. … Hofmann S. (FEBS Lett. 1999) 3 4
  3. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PMID: 11489896) Rothbauer U. … Bauer M.F. (J. Biol. Chem. 2001) 3 4
  4. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Muehlenbein N. … Bauer M.F. (J. Biol. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TIMM10B Gene

Sources for TIMM10B Gene

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