Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIMM10B Gene

Aliases for TIMM10B Gene

  • Translocase Of Inner Mitochondrial Membrane 10B 2 3 5
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim9 B 3 4
  • Fracture Callus Protein 1 3 4
  • TIM10B 3 4
  • Tim9b 3 4
  • FXC1 3 4
  • Translocase Of Inner Mitochondrial Membrane 10 Homolog B (Yeast) 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B 3
  • Translocase Of Inner Mitochondrial Membrane 10 Homolog B 3
  • Fracture Callus 1 (Rat) Homolog 2
  • Fracture Callus 1 Homolog (Rat) 2
  • Fracture Callus 1 Homolog 3
  • TIMM9B 4

External Ids for TIMM10B Gene

Previous HGNC Symbols for TIMM10B Gene

  • FXC1

Summaries for TIMM10B Gene

Entrez Gene Summary for TIMM10B Gene

  • FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

GeneCards Summary for TIMM10B Gene

TIMM10B (Translocase Of Inner Mitochondrial Membrane 10B) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. An important paralog of this gene is ENSG00000283977.

UniProtKB/Swiss-Prot for TIMM10B Gene

  • Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Gene Wiki entry for TIMM10B Gene

Additional gene information for TIMM10B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM10B Gene

Genomics for TIMM10B Gene

GeneHancer (GH) Regulatory Elements for TIMM10B Gene

Promoters and enhancers for TIMM10B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I006479 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 562.6 0.0 -15 3.6 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 TIMM10B ENSG00000283977 ARFIP2 FAM160A2 APBB1 SMPD1 TRIM34 TRIM3 GC11P006473
GH11I006616 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.3 +137.0 136970 3.6 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B TPP1 ENSG00000255680 RRP8 OLFML1 MRPL17 RPL21P94 LOC644169 TIMM10B DCHS1 ILK
GH11I006473 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 9.9 -6.1 -6111 4.6 HDAC1 FOXA2 RB1 KLF17 SIN3A ZBTB40 RAD21 ZNF335 POLR2B GLIS2 TRIM3 GC11P006473 APBB1 SMPD1 TIMM10B ARFIP2
GH11I006400 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.3 -78.1 -78077 5.5 SIN3A BATF IRF4 SCRT2 ETV6 BCLAF1 IKZF2 RUNX3 CBFB JUNB APBB1 SMPD1 HPX TIMM10B ARFIP2 CAVIN3 GC11P006400 PIR40798
GH11I006693 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 +213.6 213552 3.3 HDAC1 PKNOX1 TAF9B ZBTB40 TCF12 ZNF121 ATF7 PHF21A CAVIN1 ZBTB11 GC11P006694 GC11P006693 RRP8 OLFML1 GVINP2 OR2AG2 ILK LOC644169 ENSG00000254400 TIMM10B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIMM10B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TIMM10B Gene

Genomic Locations for TIMM10B Gene
chr11:6,481,447-6,484,681
(GRCh38/hg38)
Size:
3,235 bases
Orientation:
Plus strand
chr11:6,502,677-6,505,911
(GRCh37/hg19)

Genomic View for TIMM10B Gene

Genes around TIMM10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM10B Gene

Proteins for TIMM10B Gene

  • Protein details for TIMM10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5J6-T10B_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim10 B
    Protein Accession:
    Q9Y5J6
    Secondary Accessions:
    • Q96FF3

    Protein attributes for TIMM10B Gene

    Size:
    103 amino acids
    Molecular mass:
    11586 Da
    Quaternary structure:
    • Component of the TIM22 complex, which core is composed of TIMM22, associated with TIMM10 (TIMM10A and/or TIMM10B), TIMM9, AGK and TIMM29 (PubMed:28712724).

neXtProt entry for TIMM10B Gene

Post-translational modifications for TIMM10B Gene

No Post-translational modifications

Other Protein References for TIMM10B Gene

No data available for DME Specific Peptides for TIMM10B Gene

Domains & Families for TIMM10B Gene

Gene Families for TIMM10B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TIMM10B Gene

Suggested Antigen Peptide Sequences for TIMM10B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5J6

UniProtKB/Swiss-Prot:

T10B_HUMAN :
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
  • Belongs to the small Tim family.
Domain:
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
Family:
  • Belongs to the small Tim family.
genes like me logo Genes that share domains with TIMM10B: view

Function for TIMM10B Gene

Molecular function for TIMM10B Gene

UniProtKB/Swiss-Prot Function:
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Gene Ontology (GO) - Molecular Function for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27554484
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIMM10B: view
genes like me logo Genes that share phenotypes with TIMM10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM10B Gene

Localization for TIMM10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM10B Gene

Mitochondrion inner membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM10B gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IDA,TAS --
GO:0005758 mitochondrial intermembrane space TAS 14726512
GO:0016020 membrane IEA --
GO:0042719 mitochondrial intermembrane space protein transporter complex IDA 14726512
genes like me logo Genes that share ontologies with TIMM10B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIMM10B Gene

Pathways & Interactions for TIMM10B Gene

genes like me logo Genes that share pathways with TIMM10B: view

Pathways by source for TIMM10B Gene

2 Reactome pathways for TIMM10B Gene

Gene Ontology (GO) - Biological Process for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006810 transport IEA --
GO:0007160 cell-matrix adhesion TAS 9731230
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TIMM10B: view

No data available for SIGNOR curated interactions for TIMM10B Gene

Drugs & Compounds for TIMM10B Gene

No Compound Related Data Available

Transcripts for TIMM10B Gene

Unigene Clusters for TIMM10B Gene

Translocase of inner mitochondrial membrane 10 homolog B (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for TIMM10B Gene

GeneLoc Exon Structure for
TIMM10B
ECgene alternative splicing isoforms for
TIMM10B

Expression for TIMM10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIMM10B Gene

This gene is overexpressed in Liver (42.7) and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM10B Gene



Protein tissue co-expression partners for TIMM10B Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMM10B Gene:

TIMM10B

SOURCE GeneReport for Unigene cluster for TIMM10B Gene:

Hs.54943

mRNA Expression by UniProt/SwissProt for TIMM10B Gene:

Q9Y5J6-T10B_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Evidence on tissue expression from TISSUES for TIMM10B Gene

  • Bone marrow(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TIMM10B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM10B Gene

Orthologs for TIMM10B Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FXC1 34 33
  • 99.35 (n)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
OneToMany
FXC1 33
  • 93.55 (n)
rat
(Rattus norvegicus)
Mammalia Timm10b 33
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Timm10b 33 16 34
  • 90.68 (n)
cow
(Bos Taurus)
Mammalia FXC1 34 33
  • 89.61 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8097 33
zebrafish
(Danio rerio)
Actinopterygii timm10b 33 34
  • 63.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tim9b 34
  • 27 (a)
OneToMany
Species where no ortholog for TIMM10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMM10B Gene

ENSEMBL:
Gene Tree for TIMM10B (if available)
TreeFam:
Gene Tree for TIMM10B (if available)

Paralogs for TIMM10B Gene

Paralogs for TIMM10B Gene

(2) SIMAP similar genes for TIMM10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TIMM10B: view

Variants for TIMM10B Gene

Sequence variations from dbSNP and Humsavar for TIMM10B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000365664 -- 6,481,926(+) C/G intron_variant
rs1000681000 -- 6,484,558(+) G/C 3_prime_UTR_variant
rs1001483841 -- 6,482,248(+) C/T 3_prime_UTR_variant
rs1002050326 -- 6,482,457(+) A/G 3_prime_UTR_variant
rs1002259766 -- 6,484,191(+) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM10B Gene

Variant ID Type Subtype PubMed ID
esv3625266 CNV gain 21293372
nsv972944 CNV duplication 23825009

Variation tolerance for TIMM10B Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIMM10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM10B Gene

Disorders for TIMM10B Gene

Additional Disease Information for TIMM10B

No disorders were found for TIMM10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM10B Gene

Publications for TIMM10B Gene

  1. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. (PMID: 10552927) Jin H … Vetrie DL (Genomics 1999) 2 3 4 58
  2. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. (PMID: 28712724) Vukotic M … Langer T (Molecular cell 2017) 3 4 58
  3. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Mühlenbein N … Bauer MF (The Journal of biological chemistry 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PMID: 11489896) Rothbauer U … Bauer MF (The Journal of biological chemistry 2001) 3 4 58

Products for TIMM10B Gene

Sources for TIMM10B Gene

Content
Loading form....