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Aliases for TIMM10B Gene

Aliases for TIMM10B Gene

  • Translocase Of Inner Mitochondrial Membrane 10B 2 3 5
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim9 B 3 4
  • Fracture Callus Protein 1 3 4
  • TIM10B 3 4
  • Tim9b 3 4
  • FXC1 3 4
  • Translocase Of Inner Mitochondrial Membrane 10 Homolog B (Yeast) 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B 3
  • Translocase Of Inner Mitochondrial Membrane 10 Homolog B 3
  • Fracture Callus 1 (Rat) Homolog 2
  • Fracture Callus 1 Homolog (Rat) 2
  • Fracture Callus 1 Homolog 3
  • TIMM9B 4

External Ids for TIMM10B Gene

Previous HGNC Symbols for TIMM10B Gene

  • FXC1

Summaries for TIMM10B Gene

Entrez Gene Summary for TIMM10B Gene

  • FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

GeneCards Summary for TIMM10B Gene

TIMM10B (Translocase Of Inner Mitochondrial Membrane 10B) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. An important paralog of this gene is ENSG00000283977.

UniProtKB/Swiss-Prot for TIMM10B Gene

  • Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Gene Wiki entry for TIMM10B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM10B Gene

Genomics for TIMM10B Gene

Regulatory Elements for TIMM10B Gene

Enhancers for TIMM10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G006458 1.1 ENCODE 18.7 -21.9 -21911 2.4 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SP3 SP5 TIMM10B ARFIP2 DNHD1 RRP8 FAM160A2 APBB1 SMPD1 GC11P006457 GC11M006470
GH11G006479 1.3 ENCODE dbSUPER 12.5 0.0 -15 3.6 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SP3 TIMM10B FAM160A2 APBB1 SMPD1 TRIM34 TRIM3
GH11G006400 1.3 Ensembl ENCODE dbSUPER 10.2 -78.1 -78078 5.5 TBL1XR1 ZBTB40 ZNF766 SCRT2 RELB ETV6 IKZF2 CREM CBFB JUNB SMPD1 HPX ARFIP2 TIMM10B CAVIN3 APBB1 GC11P006400 PIR40798
GH11G006473 1.2 ENCODE dbSUPER 9.9 -6.1 -6111 4.6 FOXA2 AGO1 SIN3A GLIS2 KDM4B ZNF263 NFYC SMARCA4 GLIS1 PRDM4 TRIM3 APBB1 SMPD1 TIMM10B
GH11G006523 0.6 ENCODE 16.6 +42.0 42019 0.2 FOSL1 JUND GATA2 JUN CUX1 FOS TIMM10B ENSG00000255390 TPP1 ARFIP2 APBB1 SMPD1 ILK TAF10 ENSG00000254641 DNHD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIMM10B on UCSC Golden Path with GeneCards custom track

Promoters for TIMM10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036302 -47 1601 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 FOS

Genomic Location for TIMM10B Gene

Chromosome:
11
Start:
6,481,447 bp from pter
End:
6,484,681 bp from pter
Size:
3,235 bases
Orientation:
Plus strand

Genomic View for TIMM10B Gene

Genes around TIMM10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM10B Gene

Proteins for TIMM10B Gene

  • Protein details for TIMM10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5J6-T10B_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim10 B
    Protein Accession:
    Q9Y5J6
    Secondary Accessions:
    • Q96FF3

    Protein attributes for TIMM10B Gene

    Size:
    103 amino acids
    Molecular mass:
    11586 Da
    Quaternary structure:
    • Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein TIMM10B/FXC1 and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. Also forms a complex composed of TIMM9, TIMM10/TIM10A and TIMM10B/FXC1.

neXtProt entry for TIMM10B Gene

Post-translational modifications for TIMM10B Gene

No Post-translational modifications

Other Protein References for TIMM10B Gene

No data available for DME Specific Peptides for TIMM10B Gene

Domains & Families for TIMM10B Gene

Gene Families for TIMM10B Gene

Protein Domains for TIMM10B Gene

Suggested Antigen Peptide Sequences for TIMM10B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5J6

UniProtKB/Swiss-Prot:

T10B_HUMAN :
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B/FXC1 from the cytoplasm into the mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across the mitochondrial outer membrane (By similarity).
  • Belongs to the small Tim family.
Domain:
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10B/FXC1 from the cytoplasm into the mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across the mitochondrial outer membrane (By similarity).
Family:
  • Belongs to the small Tim family.
genes like me logo Genes that share domains with TIMM10B: view

Function for TIMM10B Gene

Molecular function for TIMM10B Gene

UniProtKB/Swiss-Prot Function:
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Gene Ontology (GO) - Molecular Function for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27554484
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIMM10B: view
genes like me logo Genes that share phenotypes with TIMM10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM10B Gene

Localization for TIMM10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM10B Gene

Mitochondrion inner membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM10B gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005758 mitochondrial intermembrane space TAS 14726512
GO:0016020 membrane IEA --
GO:0042719 mitochondrial intermembrane space protein transporter complex IDA 14726512
genes like me logo Genes that share ontologies with TIMM10B: view

Pathways & Interactions for TIMM10B Gene

genes like me logo Genes that share pathways with TIMM10B: view

Pathways by source for TIMM10B Gene

2 Reactome pathways for TIMM10B Gene

Gene Ontology (GO) - Biological Process for TIMM10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006810 transport IEA --
GO:0007160 cell-matrix adhesion TAS 9731230
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TIMM10B: view

No data available for SIGNOR curated interactions for TIMM10B Gene

Drugs & Compounds for TIMM10B Gene

No Compound Related Data Available

Transcripts for TIMM10B Gene

Unigene Clusters for TIMM10B Gene

Translocase of inner mitochondrial membrane 10 homolog B (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for TIMM10B Gene

GeneLoc Exon Structure for
TIMM10B
ECgene alternative splicing isoforms for
TIMM10B

Expression for TIMM10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIMM10B Gene

This gene is overexpressed in Liver (42.7) and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM10B Gene



Protein tissue co-expression partners for TIMM10B Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMM10B Gene:

TIMM10B

SOURCE GeneReport for Unigene cluster for TIMM10B Gene:

Hs.54943

mRNA Expression by UniProt/SwissProt for TIMM10B Gene:

Q9Y5J6-T10B_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Evidence on tissue expression from TISSUES for TIMM10B Gene

  • Bone marrow(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TIMM10B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM10B Gene

Orthologs for TIMM10B Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FXC1 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
FXC1 34
  • 93.55 (n)
rat
(Rattus norvegicus)
Mammalia Timm10b 34
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Timm10b 34 16 35
  • 90.68 (n)
cow
(Bos Taurus)
Mammalia FXC1 34 35
  • 89.61 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8097 34
zebrafish
(Danio rerio)
Actinopterygii timm10b 34 35
  • 63.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tim9b 35
  • 27 (a)
OneToMany
Species where no ortholog for TIMM10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMM10B Gene

ENSEMBL:
Gene Tree for TIMM10B (if available)
TreeFam:
Gene Tree for TIMM10B (if available)

Paralogs for TIMM10B Gene

Paralogs for TIMM10B Gene

(2) SIMAP similar genes for TIMM10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TIMM10B: view

Variants for TIMM10B Gene

Sequence variations from dbSNP and Humsavar for TIMM10B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000365664 -- 6,481,926(+) CACTT(C/G)CCGTA intron-variant, upstream-variant-2KB
rs1000681000 -- 6,484,558(+) AAACA(C/G)GTTTG utr-variant-3-prime
rs1001483841 -- 6,482,248(+) AAGGC(C/T)TTGGA upstream-variant-2KB, utr-variant-3-prime
rs1002050326 -- 6,482,457(+) AGTGC(A/G)TATCT upstream-variant-2KB, utr-variant-3-prime
rs1002259766 -- 6,484,191(+) TCAAG(A/C)AGTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIMM10B Gene

Variant ID Type Subtype PubMed ID
esv3625266 CNV gain 21293372
nsv972944 CNV duplication 23825009

Variation tolerance for TIMM10B Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM10B Gene

Disorders for TIMM10B Gene

Relevant External Links for TIMM10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM10B

No disorders were found for TIMM10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM10B Gene

Publications for TIMM10B Gene

  1. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PMID: 10552927) Jin H. … Vetrie D.L.P. (Genomics 1999) 2 3 4 64
  2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Muehlenbein N. … Bauer M.F. (J. Biol. Chem. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PMID: 11489896) Rothbauer U. … Bauer M.F. (J. Biol. Chem. 2001) 3 4 64
  5. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer M.F. … Hofmann S. (FEBS Lett. 1999) 3 4 64

Products for TIMM10B Gene

Sources for TIMM10B Gene

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