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TIMM10B Gene

protein-coding   GIFtS: 44
GCID: GC11P006502

Translocase Of Inner Mitochondrial Membrane 10 Homolog B...

(Previous names: fracture callus 1 (rat) homolog, fracture callus 1 homolog...)
(Previous symbol: FXC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Inner Mitochondrial Membrane 10 Homolog B (Yeast)1 2     Tim9b2
FXC11 2 3 5     Fracture Callus 1 Homolog2
Fracture Callus Protein 12 3     Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B2
Mitochondrial Import Inner Membrane Translocase Subunit Tim9 B2 3     FxC13
Fracture Callus 1 (Rat) Homolog1     TIM9B3
Fracture Callus 1 Homolog (Rat)1     TIMM9B3
TIM10B2     Tim10b3

External Ids:    HGNC: 40221   Entrez Gene: 265152   Ensembl: ENSG000001322867   OMIM: 6073885   UniProtKB: Q9Y5J63   

Export aliases for TIMM10B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIMM10B Gene:
FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric
complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of
hydrophobic membrane proteins into the mitochondrial inner membrane.(supplied by OMIM, Apr 2004)

GeneCards Summary for TIMM10B Gene:
TIMM10B (translocase of inner mitochondrial membrane 10 homolog B (yeast)) is a protein-coding gene. Diseases associated with TIMM10B include familial deafness, and thyroiditis. An important paralog of this gene is ENSG00000265264.

UniProtKB/Swiss-Prot: T10B_HUMAN, Q9Y5J6
Function: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass
transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase
that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking
point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial
intermembrane space

Gene Wiki entry for TIMM10B (FXC1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TIMM10B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM10B promoter sequence
   Search Chromatin IP Primers for TIMM10B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMM10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

TIMM10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM10B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006502:  view genomic region     (about GC identifiers)

Start:
6,502,677 bp from pter      End:
6,505,911 bp from pter
Size:
3,235 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T10B_HUMAN, Q9Y5J6 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim10 B  
Size: 103 amino acids; 11586 Da
Subunit: Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein
TIMM10B/FXC1 and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10.
Also forms a complex composed of TIMM9, TIMM10/TIM10A and TIMM10B/FXC1
Secondary accessions: Q96FF3

Explore the universe of human proteins at neXtProt for TIMM10B: NX_Q9Y5J6

Explore proteomics data for TIMM10B at MOPED


See TIMM10B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036324.1  
ENSEMBL proteins: 
 ENSP00000254616   ENSP00000436579   ENSP00000433087   ENSP00000436948  
Reactome Protein details: Q9Y5J6

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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004217 Tim10/DDP_fam_Znf

Graphical View of Domain Structure for InterPro Entry Q9Y5J6

ProtoNet protein and cluster: Q9Y5J6

1 Blocks protein domain: IPB004217 Zn-finger

UniProtKB/Swiss-Prot: T10B_HUMAN, Q9Y5J6
Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial
intermembrane space. However, during the transit of TIMM10B/FXC1 from the cytoplasm into the mitochondrion, the
Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across the
mitochondrial outer membrane (By similarity)
Similarity: Belongs to the small Tim family


TIMM10B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: T10B_HUMAN, Q9Y5J6
Function: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass
transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase
that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking
point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial
intermembrane space

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0046872metal ion binding IEA--
     
TIMM10B for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIMM10B
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miRNA
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miRTarBase miRNAs that target TIMM10B:
hsa-mir-877-3p (MIRT037012), hsa-mir-16-5p (MIRT031455)

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SwitchGear 3'UTR luciferase reporter plasmidTIMM10B 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
T10B_HUMAN, Q9Y5J6: Mitochondrion inner membrane; Peripheral membrane protein

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005743mitochondrial inner membrane TAS--
GO:0005758mitochondrial intermembrane space TAS14726512
GO:0042719mitochondrial intermembrane space protein transporter complex IDA14726512

TIMM10B for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TIMM10B About    
See pathways by source

SuperPathContained pathways About
1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30
2Mitochondrial Protein Import
Mitochondrial Protein Import

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for TIMM10B
    Mitochondrial protein import



TIMM10B for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIMM10B
Interactions:

    Search GeneGlobe Interaction Network for TIMM10B

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for TIMM10B (Q9Y5J63 ENSP000002546164) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
TIMM10P620723, ENSP000002572454I2D: score=1 STRING: ENSP00000257245
TIMM22Q9Y5843, ENSP000003202364I2D: score=1 STRING: ENSP00000320236
TIMM9Q9Y5J73I2D: score=1 
TIMM13ENSP000002155704STRING: ENSP00000215570
CHCHD4ENSP000002957674STRING: ENSP00000295767
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006626protein targeting to mitochondrion TAS--
GO:0007160cell-matrix adhesion TAS9731230
GO:0044267cellular protein metabolic process TAS--

TIMM10B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TIMM10B (T10B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TIMM10B gene: 
NM_012192.3  

Unigene Cluster for TIMM10B:

Translocase of inner mitochondrial membrane 10 homolog B (yeast)
Hs.54943  [show with all ESTs]
Unigene Representative Sequence: NM_012192
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000254616(uc001mdn.4 uc001mdo.4) ENST00000528908 ENST00000530751
ENST00000531462 ENST00000533379
miRNA
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Primer
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OriGene qPCR primer pairs and template standards for TIMM10B
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  QuantiFast Probe-based Assays in human, mouse, rat TIMM10B

Additional mRNA sequence: 

AF152355.1 AF183415.1 AK002130.1 AK058048.1 AK311763.1 BC011014.1 

17 DOTS entries:

DT.454579  DT.100783675  DT.95085372  DT.95085369  DT.100783666  DT.95085382  DT.97802157  DT.100783667 
DT.100783674  DT.95085366  DT.100783670  DT.100027846  DT.100687156  DT.120709462  DT.100648397  DT.120709468 
DT.429715 

Selected AceView cDNA sequences (see all 282):

AL528403 CA438943 CR607360 BP376097 BE391074 BM713570 BU681855 AL548974 
C21011 AI347493 AI095923 AW129951 BP362855 AW517348 BQ690187 BQ718911 
BQ066622 BI523998 CR595140 BM709673 BP368813 BQ928410 AI052126 AF152355 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10B    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1:                                      -         
SP2:                                                
SP3:                    -                           
SP4:                                                


ECgene alternative splicing isoforms for TIMM10B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TIMM10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TIMM10B Expression
About this image


TIMM10B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Ovary (Reproductive System)
         Primary Oocyte Primary Follicle
 
 Gonad
         Primary Oocyte Primary Follicle
 
 Thyroid (Endocrine System)
TIMM10B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TIMM10B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.54943

UniProtKB/Swiss-Prot: T10B_HUMAN, Q9Y5J6
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM10B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TIMM10B gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Timm10b1 , 5 fractured callus expressed transcript 15
translocase of inner mitochondrial membrane 10B1
90.68(n)1
92.47(a)1
  7 (55.93 cM)5
143561  NM_019502.21  NP_062375.11 
 1056400565 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
59(a)
1 → many
GL343952.1(73165-73555)
African clawed frog
(Xenopus laevis)
Amphibia Xl.80972 Xenopus laevis transcribed sequence with weak similarity more 74.34(n)    AW638439.1 
zebrafish
(Danio rerio)
Actinopterygii timm10b1 translocase of inner mitochondrial membrane 10 homolog more 63.2(n)
63.64(a)
  550527  NM_001017829.1  NP_001017829.1 
fruit fly
(Drosophila melanogaster)
Insecta Tim9b6
Translocase of inner membrane 9b
27(a)
1 → many
X(19510696-19512570)


ENSEMBL Gene Tree for TIMM10B (if available)
TreeFam Gene Tree for TIMM10B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TIMM10B gene
ENSG000002652642  
2 SIMAP similar genes for TIMM10B using alignment to 2 protein entries:     T10B_HUMAN (see all proteins):
FXC1    TIMM9

TIMM10B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TIMM10B (see all 34)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1928278221,2
--6504802(+) CACACA/CAACAC 1 -- ut310--------
rs1829396311,2
--6504855(+) TCCTTA/CTCTAA 1 -- ut310--------
rs1417897451,2
--6504885(+) ACACCG/TCTACT 1 -- ut310--------
rs1880458611,2
--6504970(+) CATTGA/GTTTCC 1 -- ut310--------
rs1462087751,2
--6505026(+) GTTCTA/GTCCTA 1 -- ut310--------
rs1379506281,2
--6505063(+) CAAGTA/GGCAGA 1 -- ut310--------
rs1922251941,2
--6505267(+) ATCCAA/GAATGT 1 -- ut310--------
rs110408981,2
C,F,H--6505271(+) AGAATG/ATGCCA 1 -- ut3112Minor allele frequency- A:0.21NS EA NA CSA WA 785
rs1127989991,2
C,F--6505381(+) TGGAGC/TGATCT 1 -- ut311Minor allele frequency- T:0.50WA 2
rs1893364831,2
--6505459(+) GATTAC/TAGGCA 1 -- ut310--------

HapMap Linkage Disequilibrium report for TIMM10B (6502677 - 6505911 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TIMM10B: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TIMM10B
DNA2.0 Custom Variant and Variant Library Synthesis for TIMM10B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607388    OMIM disorders: --

2 diseases for TIMM10B:    
About MalaCards
familial deafness    thyroiditis


TIMM10B for disorders           About GeneDecksing


Export disorders for TIMM10B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TIMM10B gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with TIMM10B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PubMed id 10552927)1, 2, 3 Jin H.... Vetrie D.L.P. (Genomics 1999)
  2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)1, 2 Muehlenbein N.... Bauer M.F. (J. Biol. Chem. 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PubMed id 11489896)1, 2 Rothbauer U.... Bauer M.F. (J. Biol. Chem. 2001)
  5. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2 Bauer M.F.... Hofmann S. (FEBS Lett. 1999)
  6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
  7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  8. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26515 HGNC: 4022 AceView: FXC1andFLJ35709 Ensembl:ENSG00000132286 euGenes: HUgn26515
ECgene: TIMM10B H-InvDB: TIMM10B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TIMM10B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TIMM10B gene:
Search GeneIP for patents involving TIMM10B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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