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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMM10 Gene

protein-coding   GIFtS: 54
GCID: GC11M057299

Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast)

(Previous name: translocase of inner mitochondrial membrane 10 (yeast) homolog)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast)1 2
TIM102 3 5
TIM10A2 5
Translocase Of Inner Mitochondrial Membrane 10 (Yeast) Homolog1
Mitochondrial Import Inner Membrane Translocase Subunit Tim102

External Ids:    HGNC: 118141   Entrez Gene: 265192   Ensembl: ENSG000001348097   OMIM: 6022515   UniProtKB: P620723   

Export aliases for TIMM10 gene to outside databases

Previous GC identifers: GC11M059689 GC11M058809 GC11M057546 GC11M057071 GC11M057052 GC11M057296 GC11M053644


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIMM10 Gene:
The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are
organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the
import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as
intermembrane space chaperones for the highly insoluble carrier proteins. (provided by RefSeq, Nov 2011)

GeneCards Summary for TIMM10 Gene: 
TIMM10 (translocase of inner mitochondrial membrane 10 homolog (yeast)) is a protein-coding gene. Diseases associated with TIMM10 include familial deafness, and intrahepatic cholangiocarcinoma, and among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include chaperone binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass
transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of
beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer
membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide
them through the mitochondrial intermembrane space

Gene Wiki entry for TIMM10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMM10 gene promoter:
         SRF   SRF (504 AA)   Pax-6   Lmo2   Tal-1beta   Evi-1   RORalpha2   HEN1   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMM10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1-q12.3   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1-q12.3

TIMM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057299:  view genomic region     (about GC identifiers)

Start:
57,295,936 bp from pter      End:
57,298,276 bp from pter
Size:
2,341 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim10  
Size: 90 amino acids; 10333 Da
Subunit: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex.
The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22
complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9,
TIMM10/TIM10A and FXC1/TIM10B
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
1 PDB 3D structure from and Proteopedia for TIMM10:
2BSK (3D)    
Secondary accessions: A8K136 Q9WV99 Q9WVA0 Q9Y5J8

Explore the universe of human proteins at neXtProt for TIMM10: NX_P62072

Explore proteomics data for TIMM10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62072

  • TIMM10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMM10 Protein Expression
    REFSEQ proteins: NP_036588.1  
    ENSEMBL proteins: 
     ENSP00000257245   ENSP00000435678   ENSP00000433627  
    Reactome Protein details: P62072
    Human Recombinant Protein Products for TIMM10: 
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    Cloud-Clone Corp. Proteins for TIMM10 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005744mitochondrial inner membrane presequence translocase complex TAS10552927
    GO:0005758mitochondrial intermembrane space TAS14726512
    GO:0042719mitochondrial intermembrane space protein transporter complex IDA14726512

    TIMM10 for ontologies           About GeneDecksing



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    Assay Products for TIMM10: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR004217 Tim10/DDP_fam_Znf
     IPR027247 Tim10/Tim12

    Graphical View of Domain Structure for InterPro Entry P62072

    ProtoNet protein and cluster: P62072

    1 Blocks protein domain: IPB004217 Zn-finger

    UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072
    Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial
    intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues
    probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer
    membrane (Probable)
    Similarity: Belongs to the small Tim family


    TIMM10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM10_HUMAN, P62072
    Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass
    transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of
    beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer
    membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide
    them through the mitochondrial intermembrane space

         Genatlas biochemistry entry for TIMM10:
    translocase of inner mitochondrial membrane 10 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S
    cerevisiae Tim10p,and essential for escorting a class of multimembrane-spanning proteins

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IDA16387659
    GO:0005515protein binding IPI14726512
    GO:0008270zinc ion binding TAS10552927
    GO:0042803protein homodimerization activity IPI16387659
    GO:0051087chaperone binding IPI16387659
         
    TIMM10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMM10 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMM10 
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM10:
    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-3202 hsa-miR-3941 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidTIMM10 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIMM10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for TIMM10
        Mitochondrial Protein Import
    Metabolism of proteins



    TIMM10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMM10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for TIMM10 (P620721, 3 ENSP000002572454) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIMM9Q9Y5J71, 3EBI-1200391,EBI-1200370 I2D: score=1 
    TIMM22Q9Y5843, ENSP000003202364I2D: score=2 STRING: ENSP00000320236
    TIMM10BQ9Y5J63, ENSP000002546164I2D: score=1 STRING: ENSP00000254616
    TOMM20ENSP000003555664STRING: ENSP00000355566
    TOMM22ENSP000002160344STRING: ENSP00000216034
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS10552927
    GO:0007605sensory perception of sound TAS10552927
    GO:0044267cellular protein metabolic process TAS--
    GO:0045039protein import into mitochondrial inner membrane ISS14726512
    GO:0072321chaperone-mediated protein transport IDA16387659

    TIMM10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMM10 (TIM10)

    Search CenterWatch for drugs/clinical trials and news about TIMM10 / TIM10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMM10 gene: 
    NM_012456.2  

    Unigene Cluster for TIMM10:

    Translocase of inner mitochondrial membrane 10 homolog (yeast)
    Hs.235750  [show with all ESTs]
    Unigene Representative Sequence: BC011987
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257245(uc001nkm.1) ENST00000525587 ENST00000525158
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM10:
    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-3202 hsa-miR-3941 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidTIMM10 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM10

    Additional mRNA sequence: 

    AF150089.1 AF152354.1 AK289751.1 BC011987.1 BC032133.2 

    5 DOTS entries:

    DT.86840693  DT.102822448  DT.120682991  DT.100792476  DT.120682989 

    24/183 AceView cDNA sequences (see all 183):

    AF152354 BX282125 BC032133 BG231892 BM874616 AW178875 BE349980 BM668965 
    AA147779 BG683054 CF530058 CD678817 BP873011 BQ011801 CD678816 BQ011318 
    AJ572794 BQ013017 CB121496 BI835353 W60915 BE047615 BQ013892 AA687778 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:              -                     
    SP2:                                    


    ECgene alternative splicing isoforms for TIMM10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMM10 expression in normal human tissues (normalized intensities)      TIMM10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCCCTGT
    TIMM10 Expression
    About this image


    TIMM10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See TIMM10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMM10

    SOURCE GeneReport for Unigene cluster: Hs.235750

    UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072
    Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including TIMM10: 
              Mitochondria in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TIMM10 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm101 , 5 translocase of inner mitochondrial membrane 10 homolog more5
    translocase of inner mitochondrial membrane 101
    92.59(n)1
    100(a)1
      2 (49.45 cM)5
    300591  NM_013899.21  NP_038927.21 
     848269975 
    chicken
    (Gallus gallus)
    Aves TIMM101 translocase of inner mitochondrial membrane 10 homolog more 78.89(n)
    87.78(a)
      425202  XM_422986.3  XP_422986.2 
    lizard
    (Anolis carolinensis)
    Reptilia TIMM106
    Uncharacterized protein
    96(a)
    1 ↔ 1
    1(91753871-91756973)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238152 Xenopus laevis transcribed sequence with strong similarity more 78.24(n)    48053845 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283172 Transcribed sequence with moderate similarity to protein more 75.46(n)    CB361419.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG424971 CG42497 70.18(n)
    71.05(a)
      8674071  NM_137762.3  NP_611606.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tin-101 Protein TIN-10 63.11(n)
    58.67(a)
      176580  NM_067079.4  NP_499480.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIM10(YHR005C-A)4 Essential protein of the mitochondrial intermembrane more   --   8(115901-115620) 856395  NP_011869.1 


    ENSEMBL Gene Tree for TIMM10 (if available)
    TreeFam Gene Tree for TIMM10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMM10 gene
    1 SIMAP similar gene for TIMM10 using alignment to 1 protein entry:     TIM10_HUMAN:
    TIMM9

    TIMM10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/85 SNPs in TIMM10 are shown (see all 85)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108966231,2
    C,F,A,H--57295864(+) CATTAA/GTCTCC 1 -- ds500125Minor allele frequency- G:0.35NS EA NA WA CSA 2772
    rs714702721,2
    C--57295957(+) TTGTTTATAT   
       ATA
    /-
    TATAT
    1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1132664521,2
    C--57296048(+) GGAGAC/AAGCGC 1 -- ut312Minor allele frequency- A:0.08CSA WA 121
    rs1470270251,2
    C--57296124(+) CCCAA-/CAGGGA 1 -- ut310--------
    rs2009881721,2
    --57296307(+) CATCGC/GTCCAG 2 D E mis10--------
    rs1428294921,2
    C,F--57296313(+) TCCAGG/TCACAC 2 * C stg12Minor allele frequency- T:0.00NA EU 5875
    rs1999924841,2
    --57296327(+) CTCGCC/TCTTGG 2 S G mis10--------
    rs2019389581,2
    --57296415(+) AAGGTC/GATGTC 1 -- int10--------
    rs107921011,2
    C,F,A,H--57296659(+) GCAATG/ACTTAC 1 -- int122Minor allele frequency- A:0.26NS EA NA WA CSA 2351
    rs1395041161,2
    C--57296676(+) CCTAAA/GAGACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TIMM10 (57295936 - 57298276 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TIMM10: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMM10
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602251    OMIM disorders: --

    4 diseases for TIMM10:    About MalaCards
    familial deafness    intrahepatic cholangiocarcinoma    cholangiocarcinoma    rhabdomyosarcoma


    TIMM10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIMM10
    Human Genome Epidemiology (HuGE) Navigator: TIMM10 (1 document)

    Export disorders for TIMM10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMM10 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with TIMM10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PubMed id 10552927)1, 2, 3 Jin H.... Vetrie D.L.P. (1999)
    2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2, 9 Bauer M.F.... Hofmann S. (1999)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. (PubMed id 16387659)1, 2 Webb C.T.... Gulbis J.M. (2006)
    5. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)1, 2 Muhlenbein N....Bauer M.F. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PubMed id 11489896)1, 2 Rothbauer U.... Bauer M.F. (2001)
    8. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26519 HGNC: 11814 AceView: TIMM10 Ensembl:ENSG00000134809 euGenes: HUgn26519
    ECgene: TIMM10 H-InvDB: TIMM10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMM10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMM10 gene:
    Search GeneIP for patents involving TIMM10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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