Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TIMM10 Gene

protein-coding   GIFtS: 56
GCID: GC11M057299

Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast)

(Previous name: translocase of inner mitochondrial membrane 10 (yeast) homolog)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast)1 2
TIM102 3 5
TIM10A2 5
Translocase Of Inner Mitochondrial Membrane 10 (Yeast) Homolog1
Mitochondrial Import Inner Membrane Translocase Subunit Tim102

External Ids:    HGNC: 118141   Entrez Gene: 265192   Ensembl: ENSG000001348097   OMIM: 6022515   UniProtKB: P620723   

Export aliases for TIMM10 gene to outside databases

Previous GC identifers: GC11M059689 GC11M058809 GC11M057546 GC11M057071 GC11M057052 GC11M057296 GC11M053644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TIMM10 Gene:
The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are
organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the
import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as
intermembrane space chaperones for the highly insoluble carrier proteins. (provided by RefSeq, Nov 2011)

GeneCards Summary for TIMM10 Gene:
TIMM10 (translocase of inner mitochondrial membrane 10 homolog (yeast)) is a protein-coding gene. GO annotations related to this gene include chaperone binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072
Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass
transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of
beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer
membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide
them through the mitochondrial intermembrane space

Gene Wiki entry for TIMM10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIMM10 gene promoter:
         SRF   SRF (504 AA)   Pax-6   Lmo2   Tal-1beta   Evi-1   RORalpha2   HEN1   ITF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMM10 promoter sequence
   Search Chromatin IP Primers for TIMM10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1-q12.3   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1-q12.3

TIMM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057299:  view genomic region     (about GC identifiers)

Start:
57,295,936 bp from pter      End:
57,298,276 bp from pter
Size:
2,341 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072 (See protein sequence)
Recommended Name: Mitochondrial import inner membrane translocase subunit Tim10  
Size: 90 amino acids; 10333 Da
Subunit: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex.
The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22
complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9,
TIMM10/TIM10A and FXC1/TIM10B
1 PDB 3D structure from and Proteopedia for TIMM10:
2BSK (3D)    
Secondary accessions: A8K136 Q9WV99 Q9WVA0 Q9Y5J8

Explore the universe of human proteins at neXtProt for TIMM10: NX_P62072

Explore proteomics data for TIMM10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIMM10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036588.1  
    ENSEMBL proteins: 
     ENSP00000257245   ENSP00000435678   ENSP00000433627  
    Reactome Protein details: P62072

    TIMM10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TIMM10
    OriGene Protein Over-expression Lysate for TIMM10
    OriGene MassSpec for TIMM10
    OriGene Custom Protein Services for TIMM10
    GenScript Custom Purified and Recombinant Proteins Services for TIMM10
    Novus Biologicals TIMM10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIMM10

     
    Search eBioscience for Proteins for TIMM10 

     
    antibodies-online proteins for TIMM10 (6 products) 

     
    antibodies-online peptides for TIMM10

    TIMM10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TIMM10
    Novus Biologicals TIMM10 Antibody
    Abcam antibodies for TIMM10
    Cloud-Clone Corp. Antibodies for TIMM10
    Search ThermoFisher Antibodies for TIMM10
    antibodies-online antibodies for TIMM10 (4 products) 

    TIMM10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TIMM10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIMM10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIMM10
    Cloud-Clone Corp. CLIAs for TIMM10
    Search eBioscience for ELISAs for TIMM10 
    antibodies-online kits for TIMM10 (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR004217 Tim10/DDP_fam_Znf
     IPR027247 Tim10/Tim12

    Graphical View of Domain Structure for InterPro Entry P62072

    ProtoNet protein and cluster: P62072

    1 Blocks protein domain: IPB004217 Zn-finger

    UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072
    Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial
    intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues
    probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer
    membrane (Probable)
    Similarity: Belongs to the small Tim family


    Find genes that share domains with TIMM10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM10_HUMAN, P62072
    Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass
    transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of
    beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer
    membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide
    them through the mitochondrial intermembrane space

         Genatlas biochemistry entry for TIMM10:
    translocase of inner mitochondrial membrane 10 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S
    cerevisiae Tim10p,and essential for escorting a class of multimembrane-spanning proteins

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IDA16387659
    GO:0005515protein binding IPI14726512
    GO:0008270zinc ion binding TAS10552927
    GO:0042803protein homodimerization activity IPI16387659
    GO:0051087chaperone binding IPI16387659
         
    Find genes that share ontologies with TIMM10           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TIMM10

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIMM10:
    hsa-mir-125b-5p (MIRT046101), hsa-mir-26b-5p (MIRT029571), hsa-mir-30a-5p (MIRT028579)

    Block miRNA regulation of human, mouse, rat TIMM10 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TIMM10:
    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-3202 hsa-miR-3941 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidTIMM10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIMM10
    Predesigned siRNA for gene silencing in human, mouse, rat TIMM10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMM10

    Clone
    Products:
         
    OriGene clones in human, mouse for TIMM10 (see all 7)
    OriGene ORF clones in mouse, rat for TIMM10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMM10 (NM_012456)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIMM10
    Browse ESI BIO Cell Lines and PureStem Progenitors for TIMM10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TIM10_HUMAN, P62072: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3
    extracellular3
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005744mitochondrial inner membrane presequence translocase complex TAS10552927
    GO:0005758mitochondrial intermembrane space TAS14726512
    GO:0042719mitochondrial intermembrane space protein transporter complex IDA14726512

    Find genes that share ontologies with TIMM10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TIMM10 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import


    Find genes that share SuperPaths with TIMM10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TIMM10
        Mitochondrial protein import


        Pathway & Disease-focused RT2 Profiler PCR Array including TIMM10: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TIMM10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIMM10 (P620721, 3 ENSP000002572454) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIMM9Q9Y5J71, 3EBI-1200391,EBI-1200370 I2D: score=1 
    TIMM10BQ9Y5J63, ENSP000002546164I2D: score=1 STRING: ENSP00000254616
    TIMM22Q9Y5843, ENSP000003202364I2D: score=2 STRING: ENSP00000320236
    TOMM20ENSP000003555664STRING: ENSP00000355566
    TOMM22ENSP000002160344STRING: ENSP00000216034
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS10552927
    GO:0007605sensory perception of sound TAS10552927
    GO:0044267cellular protein metabolic process TAS--
    GO:0045039protein import into mitochondrial inner membrane ISS14726512
    GO:0072321chaperone-mediated protein transport IDA16387659

    Find genes that share ontologies with TIMM10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIMM10 (TIM10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TIMM10 gene: 
    NM_012456.2  

    Unigene Cluster for TIMM10:

    Translocase of inner mitochondrial membrane 10 homolog (yeast)
    Hs.235750  [show with all ESTs]
    Unigene Representative Sequence: BC011987
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257245(uc001nkm.1) ENST00000525587 ENST00000525158
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TIMM10 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TIMM10:
    hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-3202 hsa-miR-3941 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidTIMM10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TIMM10
    Predesigned siRNA for gene silencing in human, mouse, rat TIMM10
    Clone
    Products:
         
    OriGene clones in human, mouse for TIMM10 (see all 7)
    OriGene ORF clones in mouse, rat for TIMM10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMM10 (NM_012456)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIMM10
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMM10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMM10
      QuantiTect SYBR Green Assays in human, mouse, rat TIMM10
      QuantiFast Probe-based Assays in human, mouse, rat TIMM10

    Additional mRNA sequence: 

    AF150089.1 AF152354.1 AK289751.1 BC011987.1 BC032133.2 

    5 DOTS entries:

    DT.86840693  DT.102822448  DT.120682991  DT.100792476  DT.120682989 

    Selected AceView cDNA sequences (see all 183):

    BI835353 BP873011 BU737670 BQ011801 BM755437 AA147779 W60915 BE047615 
    BP429972 CD678817 BQ012276 AF152354 BG231892 BM668965 CF530058 BE349980 
    CB121496 BQ011318 AI568254 AJ572794 BX282125 BM706045 CD678816 BM663017 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:              -                     
    SP2:                                    


    ECgene alternative splicing isoforms for TIMM10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TIMM10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCCCTGT
    TIMM10 Expression
    About this image


    TIMM10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    TIMM10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIMM10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.235750

    UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072
    Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including TIMM10: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TIMM10
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMM10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMM10
    QuantiTect SYBR Green Assays in human, mouse, rat TIMM10
    QuantiFast Probe-based Assays in human, mouse, rat TIMM10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TIMM10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timm101 , 5 translocase of inner mitochondrial membrane 10 homolog more5
    translocase of inner mitochondrial membrane 101
    92.59(n)1
    100(a)1
      2 (49.45 cM)5
    300591  NM_013899.21  NP_038927.21 
     848269975 
    chicken
    (Gallus gallus)
    Aves TIMM101 translocase of inner mitochondrial membrane 10 homolog more 78.89(n)
    87.78(a)
      425202  XM_422986.4  XP_422986.2 
    lizard
    (Anolis carolinensis)
    Reptilia TIMM106
    translocase of inner mitochondrial membrane 10 hom...
    94(a)
    1 ↔ 1
    1(91753871-91756973)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238152 Xenopus laevis transcribed sequence with strong similarity more 78.24(n)    48053845 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283172 Transcribed sequence with moderate similarity to protein more 75.46(n)    CB361419.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tim101 Translocase of inner membrane 10 70.18(n)
    71.05(a)
      37478  NM_166474.2  NP_726104.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tin-101 tin-10 63.11(n)
    58.67(a)
      176580  NM_067079.5  NP_499480.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIM10(YHR005C-A)4 Essential protein of the mitochondrial intermembrane more   --   8(115901-115620) 856395  NP_011869.1 


    ENSEMBL Gene Tree for TIMM10 (if available)
    TreeFam Gene Tree for TIMM10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TIMM10 gene
    1 SIMAP similar gene for TIMM10 using alignment to 1 protein entry:     TIM10_HUMAN:
    TIMM9

    Find genes that share paralogs with TIMM10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TIMM10 (see all 85)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108966231,2
    C,F,A,H--57295864(+) CATTAA/GTCTCC 1 -- ds500125Minor allele frequency- G:0.35NS EA NA WA CSA 2772
    rs714702721,2
    C--57295957(+) TTGTTTATAT   
       ATA
    /-
    TATAT
    1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1132664521,2
    C--57296048(+) GGAGAC/AAGCGC 1 -- ut312Minor allele frequency- A:0.08CSA WA 121
    rs1470270251,2
    C--57296124(+) CCCAA-/CAGGGA 1 -- ut310--------
    rs2009881721,2
    --57296307(+) CATCGC/GTCCAG 2 D E mis10--------
    rs1428294921,2
    C,F--57296313(+) TCCAGG/TCACAC 2 * C stg12Minor allele frequency- T:0.00NA EU 5875
    rs1999924841,2
    --57296327(+) CTCGCC/TCTTGG 2 S G mis10--------
    rs2019389581,2
    --57296415(+) AAGGTC/GATGTC 1 -- int10--------
    rs107921011,2
    C,F,A,H--57296659(+) GCAATG/ACTTAC 1 -- int122Minor allele frequency- A:0.26NS EA NA WA CSA 2351
    rs1395041161,2
    C--57296676(+) CCTAAA/GAGACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TIMM10 (57295936 - 57298276 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TIMM10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMM10
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMM10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602251    OMIM disorders: --


    Find genes that share disorders with TIMM10           About GenesLikeMe

    Genetic Association Database (GAD): TIMM10
    Human Genome Epidemiology (HuGE) Navigator: TIMM10 (1 document)

    Export disorders for TIMM10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TIMM10 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TIMM10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PubMed id 10552927)1, 2, 3 Jin H.... Vetrie D.L.P. (Genomics 1999)
    2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)1, 2, 9 Bauer M.F.... Hofmann S. (FEBS Lett. 1999)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. (PubMed id 16387659)1, 2 Webb C.T.... Gulbis J.M. (Mol. Cell 2006)
    5. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)1, 2 Muehlenbein N.... Bauer M.F. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PubMed id 11489896)1, 2 Rothbauer U.... Bauer M.F. (J. Biol. Chem. 2001)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26519 HGNC: 11814 AceView: TIMM10 Ensembl:ENSG00000134809 euGenes: HUgn26519
    ECgene: TIMM10 H-InvDB: TIMM10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TIMM10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIMM10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TIMM10 gene:
    Search GeneIP for patents involving TIMM10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TIMM10  
     OriGene qPCR primer pairs and template standards for TIMM10   OriGene Protein Over-expression Lysate for TIMM10  
     OriGene MassSpec for TIMM10   OriGene clones in human, mouse for TIMM10  
     OriGene qSTAR qPCR primer pairs in human, mouse for TIMM10   OriGene Purified Protein for TIMM10  
     OriGene ORF clones in mouse, rat for TIMM10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TIMM10   OriGene Custom Protein Services for TIMM10  

     
     
     Block miRNA regulation of human, mouse, rat TIMM10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TIMM10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMM10 Predesigned siRNA for gene silencing in human, mouse, rat TIMM10
     QuantiFast Probe-based Assays in human, mouse, rat TIMM10 QuantiTect SYBR Green Assays in human, mouse, rat TIMM10
     PCR Arrays including human, mouse, rat TIMM10 Search Chromatin IP Primers for TIMM10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMM10  GeneGlobe Interaction Network for TIMM10
     Regulatory tfbs in TIMM10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TIMM10 GenScript cDNA clones with any tag delivered in your preferred vector for TIMM10
     GenScript Custom Assay Services for TIMM10 GenScript Custom overexpressing Cell Line Services for TIMM10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TIMM10 (TIM10)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TIMM10 antibodies
     TIMM10 lysates
     Antibodies for TIMM10
     See all of Abcam's Antibodies, Kits and Proteins for TIMM10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TIMM10
     Antibodies for TIMM10
     ELISAs for TIMM10
     CLIAs for TIMM10



     Browse ESI BIO Cell Lines and PureStem Progenitors for TIMM10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMM10
     SwitchGear 3'UTR luciferase reporter plasmids for TIMM10
     SwitchGear Promoter luciferase reporter plasmids for TIMM10
     Search ThermoFisher Antibodies for TIMM10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM10
     Browse compounds at ApexBio
     Search Addgene for plasmids for TIMM10
      Search eBioscience for proteins for TIMM10
      Search eBioscience for elisas for TIMM10
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TIMM10
     antibodies-online antibodies for TIMM10 (4 products)
     antibodies-online kits for TIMM10 (20 products)
     antibodies-online peptides for TIMM10
     antibodies-online proteins for TIMM10 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TIMM10 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4