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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIMM10 Gene

protein-coding GIFtS: 54
GCID: GC11M057299

translocase of inner mitochondrial membrane 10 homolog (yeast)

(Previous name: translocase of inner mitochondrial membrane 10 (yeast)...)

Explore 6 diseases affiliated with
TIMM10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast)¹ ²
TIM10¹ ² ³ ⁵
TIM10A¹ ² ⁵
Translocase Of Inner Mitochondrial Membrane 10 (Yeast) Homolog¹
Mitochondrial Import Inner Membrane Translocase Subunit Tim10²

External Ids:	HGNC: 11814¹	Entrez Gene: 26519²	Ensembl: ENSG00000134809⁷	OMIM: 602251⁵	UniProtKB: P62072³

Export aliases for TIMM10 gene to outside databases

Previous GC identifers: GC11M059689 GC11M058809 GC11M057546 GC11M057071 GC11M057052 GC11M057296 GC11M053644

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIMM10:

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are

organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import

and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane

space chaperones for the highly insoluble carrier proteins. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072

Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass

transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel

precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a

chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the

mitochondrial intermembrane space

Gene Wiki entry for TIMM10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIMM10 gene promoter:
SRF SRF (504 AA) Pax-6 Lmo2 Tal-1beta Evi-1 RORalpha2 HEN1 ITF-2 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIMM10 promoter sequence

Search SABiosciences Chromatin IP Primers for TIMM10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMM10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1-q12.3 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1-q12.3

TIMM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMM10 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M057299: view genomic region (about GC identifiers)

Start:	57,295,936 bp from pter	End:	57,298,276 bp from pter
Size:	2,341 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072 (See protein sequence)

Recommended Name: Mitochondrial import inner membrane translocase subunit Tim10

Size: 90 amino acids; 10333 Da

Subunit: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The

complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex.

Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and

FXC1/TIM10B

Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side

1 PDB 3D structure from and Proteopedia for TIMM10:

2BSK (3D)

Secondary accessions: A8K136 Q9WV99 Q9WVA0 Q9Y5J8

Explore the universe of human proteins at neXtProt for TIMM10: NX_P62072

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62072

TIMM10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036588.1

ENSEMBL proteins:

ENSP00000257245 ENSP00000435678 ENSP00000433627

Reactome Protein details: P62072
Human Recombinant Protein Products:

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	Novus Biologicals TIMM10 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TIMM10

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--
GO:0005743	mitochondrial inner membrane	TAS	--
GO:0005744	mitochondrial inner membrane presequence translocase complex	TAS	10552927
GO:0005758	mitochondrial intermembrane space	TAS	14726512
GO:0042719	mitochondrial intermembrane space protein transporter complex	IDA	14726512

TIMM10 for ontologies About GeneDecksing

TIMM10 Antibody Products:

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Assay Products for TIMM10:

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	Uscn ELISAs and CLIAs for TIMM10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIMM10 for domains About GeneDecksing

2 InterPro domains/families:

IPR004217 zf-Tim10_DDP

IPR027247 Tim10/Tim12

Graphical View of Domain Structure for InterPro Entry P62072

ProtoNet protein and cluster: P62072

1 Blocks protein family: IPB004217 Zn-finger

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072

Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial

intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues

probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane

(Probable)

Similarity: Belongs to the small Tim family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072

Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass

transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel

precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a

chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the

mitochondrial intermembrane space

Genatlas biochemistry entry for TIMM10:

translocase of inner mitochondrial membrane 10 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S

cerevisiae Tim10p,and essential for escorting a class of multimembrane-spanning proteins

miRNA Products:		OriGene 3'-UTR Clone: TIMM10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM10
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM10:
		hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-3202 hsa-miR-3941 hsa-miR-3179
		SwitchGear 3'UTR luciferase reporter plasmid: TIMM10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM10 (see all 7) OriGene shRNA RFP: TIMM10 OriGene siRNA: TIMM10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TIMM10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TIMM10 (NM_012456)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TIMM10
		Search LifeMap BioReagents cell lines for TIMM10

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TIMM10

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IDA	16387659
GO:0005515	protein binding	IPI	14726512
GO:0008270	zinc ion binding	TAS	10552927
GO:0042803	protein homodimerization activity	IPI	16387659
GO:0051087	chaperone binding	IPI	16387659

TIMM10 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mitochondrial Protein Import

Mitochondrial Protein Import

1.00

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for TIMM10

	Mitochondrial Protein Import
	Metabolism of proteins

TIMM10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TIMM10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/32 Interacting proteins for TIMM10 (P62072^{1, 3} ENSP00000257245⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TIMM9	Q9Y5J7¹^,³	EBI-1200391,EBI-1200370 I2D: score=1
TIMM22	Q9Y584³, ENSP00000320236⁴	I2D: score=2 STRING: ENSP00000320236
TIMM10B	Q9Y5J6³	I2D: score=1
TOMM20	ENSP00000355566⁴	STRING: ENSP00000355566
TOMM22	ENSP00000216034⁴	STRING: ENSP00000216034

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006626	protein targeting to mitochondrion	TAS	--
GO:0007605	sensory perception of sound	TAS	10552927
GO:0044267	cellular protein metabolic process	TAS	--
GO:0045039	protein import into mitochondrial inner membrane	ISS	14726512
GO:0072321	chaperone-mediated protein transport	IDA	16387659

TIMM10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIMM10
Search CenterWatch for drugs/clinical trials and news about TIMM10 / TIM10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TIMM10 gene:

NM_012456.2

Unigene Cluster for TIMM10:

Translocase of inner mitochondrial membrane 10 homolog (yeast)

Hs.235750 [show with all ESTs]

Unigene Representative Sequence: BC011987

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000257245(uc001nkm.1) ENST00000525587 ENST00000525158

miRNA Products:		OriGene 3'-UTR Clone: TIMM10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMM10
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMM10:
		hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-3202 hsa-miR-3941 hsa-miR-3179
		SwitchGear 3'UTR luciferase reporter plasmid: TIMM10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMM10 (see all 7) OriGene shRNA RFP: TIMM10 OriGene siRNA: TIMM10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMM10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMM10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TIMM10 (NM_012456)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMM10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMM10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TIMM10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMM10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM10

Additional cDNA sequence:

AF150089.1 AF152354.1 AK289751.1 BC011987.1 BC032133.2

5 DOTS entries:

DT.86840693 DT.102822448 DT.120682991 DT.100792476 DT.120682989

24/183 AceView cDNA sequences (see all 183):

AA687778 CD678816 BP873011 AF152354 BE047615 BQ013017 BX282125 BM755437

CD678817 AJ572794 AW178875 BE349980 AI568254 BM663017 BG683054 BQ012276

CB121496 CF530058 BM668965 BM874616 BU737670 BQ013892 BQ011801 BM699933

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b
SP1:					-
SP2:

ECgene alternative splicing isoforms for TIMM10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIMM10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGTCCCTGT

About this image

TIMM10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TIMM10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIMM10

SOURCE GeneReport for Unigene cluster: Hs.235750

UniProtKB/Swiss-Prot: TIM10_HUMAN, P62072

Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including TIMM10:

Mitochondria in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMM10 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMM10

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TIMM10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIMM10 gene from 9/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Timm10^{1 , 5}	translocase of inner mitochondrial membrane 10 homolog more⁵ translocase of inner mitochondrial membrane 10¹	92.59(n)¹ 100(a)¹		2 (49.45 cM)⁵ 30059¹ NM_013899.2¹ NP_038927.2¹ 84826997⁵
chicken (Gallus gallus)	Aves	TIMM10¹	translocase of inner mitochondrial membrane 10 homolog more	78.89(n) 87.78(a)		425202 XM_422986.3 XP_422986.2
lizard (Anolis carolinensis)	Reptilia	TIMM10⁶	--	96(a)	1 ↔ 1	1(91753871-91756973)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23815²	Xenopus laevis transcribed sequence with strong similarity more	78.24(n)		48053845
zebrafish (Danio rerio)	Actinopterygii	Dr.28317²	Transcribed sequence with moderate similarity to protein more	75.46(n)		CB361419.1
fruit fly (Drosophila melanogaster)	Insecta	CG42497¹	CG42497	70.18(n) 71.05(a)		8674071 NM_137762.3 NP_611606.1
worm (Caenorhabditis elegans)	Secernentea	tin-10¹	Protein TIN-10	63.11(n) 58.67(a)		176580 NM_067079.4 NP_499480.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TIM10⁶	mitochondrial import inner membrane translocase su...	25(a)	1 ↔ 1	2(12640800-12642387)
rice (Oryza sativa)	Liliopsida	--	mitochondrial import inner membrane translocase su...	34(a)	1 ↔ 1	3(34661855-34664011)

ENSEMBL Gene Tree for TIMM10 (if available)
TreeFam Gene Tree for TIMM10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10896623^1,2	C,F,A,H,	--	57295864(+)	`CATTAA/GTCTCC`	1	--	ds500¹		25		NS EA NA WA CSA	2772
rs71470272^1,2	C,	--	57295957(+)	`TTGTTTATAT ATA/-TATAT`	1	--	ut3¹		1		NA	2
rs113266452^1,2	C,	--	57296048(+)	`GGAGAC/AAGCGC`	1	--	ut3¹		2		CSA WA	121
rs147027025^1,2	C,	--	57296124(+)	`CCCAA-/CAGGGA`	1	--	ut3¹		0	--	--	--	--
rs200988172^1,2		--	57296307(+)	`CATCGC/GTCCAG`	2	D E	mis¹		0	--	--	--	--
rs142829492^1,2	C,F	--	57296313(+)	`TCCAGG/TCACAC`	2	* C	stg¹		2		NA EU	5875
rs199992484^1,2		--	57296327(+)	`CTCGCC/TCTTGG`	2	S G	mis¹		0	--	--	--	--
rs201938958^1,2		--	57296415(+)	`AAGGTC/GATGTC`	1	--	int¹		0	--	--	--	--
rs10792101^1,2	C,F,A,H,	--	57296659(+)	`GCAATG/ACTTAC`	1	--	int¹		22		NS EA NA WA CSA	2351
rs139504116^1,2		--	57296676(+)	`CCTAAA/GAGACA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TIMM10 (57295936 - 57298276 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIMM10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMM10

DNA2.0 Custom Variant and Variant Library Synthesis for TIMM10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TIMM10 for disorders           About GeneDecksing

OMIM gene information: 602251    OMIM disorders: --

6 diseases for TIMM10:    About MalaCards

familial deafness intrahepatic cholangiocarcinoma cholangiocarcinoma rhabdomyosarcoma

twinning malaria

Human Genome Epidemiology (HuGE) Navigator: TIMM10 (1 document)

Export disorders for TIMM10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TIMM10 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with TIMM10)

Utopia: connect your pdf to the dynamic
world of online information

The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PubMed id 10552927)^{1, 2, 3} Jin H.... Vetrie D.L.P. (1999)
The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PubMed id 10611480)^{1, 2, 9} Bauer M.F.... Hofmann S. (1999)
Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. (PubMed id 16387659)^{1, 2} Webb C.T.... Gulbis J.M. (2006)
Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PubMed id 14726512)^{1, 2} Muhlenbein N....Bauer M.F. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PubMed id 11489896)^{1, 2} Rothbauer U.... Bauer M.F. (2001)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)¹ Impens F....Gevaert K. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

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Entrez Gene: 26519	HGNC: 11814	AceView: TIMM10	Ensembl:ENSG00000134809	euGenes: HUgn26519
ECgene: TIMM10	H-InvDB: TIMM10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for TIMM10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TIMM10	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TIMM10 gene
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Patent Information for TIMM10 gene:
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TIMM10 Gene

translocase of inner mitochondrial membrane 10 homolog (yeast)

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translocase of inner mitochondrial membrane 10 homolog (yeast)

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