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Aliases for TIMM10 Gene

Aliases for TIMM10 Gene

  • Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast) 2 3
  • TIM10 3 4 6
  • TIM10A 3 6
  • Translocase Of Inner Mitochondrial Membrane 10 (Yeast) Homolog 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim10 3

External Ids for TIMM10 Gene

Previous GeneCards Identifiers for TIMM10 Gene

  • GC11M059689
  • GC11M058809
  • GC11M057546
  • GC11M057071
  • GC11M057052
  • GC11M057296
  • GC11M053644
  • GC11M057299

Summaries for TIMM10 Gene

Entrez Gene Summary for TIMM10 Gene

  • The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIMM10 Gene

TIMM10 (Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include protein homodimerization activity and chaperone binding.

UniProtKB/Swiss-Prot for TIMM10 Gene

  • Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Gene Wiki entry for TIMM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM10 Gene

Genomics for TIMM10 Gene

Regulatory Elements for TIMM10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIMM10 Gene

Start:
57,528,463 bp from pter
End:
57,530,803 bp from pter
Size:
2,341 bases
Orientation:
Minus strand

Genomic View for TIMM10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM10 Gene

Proteins for TIMM10 Gene

  • Protein details for TIMM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62072-TIM10_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim10
    Protein Accession:
    P62072
    Secondary Accessions:
    • A8K136
    • Q9WV99
    • Q9WVA0
    • Q9Y5J8

    Protein attributes for TIMM10 Gene

    Size:
    90 amino acids
    Molecular mass:
    10333 Da
    Quaternary structure:
    • Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

    Three dimensional structures from OCA and Proteopedia for TIMM10 Gene

neXtProt entry for TIMM10 Gene

Proteomics data for TIMM10 Gene at MOPED

Post-translational modifications for TIMM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM10 Gene

Domains for TIMM10 Gene

Protein Domains for TIMM10 Gene

Suggested Antigen Peptide Sequences for TIMM10 Gene

Graphical View of Domain Structure for InterPro Entry

P62072

UniProtKB/Swiss-Prot:

TIM10_HUMAN :
  • P62072
Domain:
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
Family:
  • Belongs to the small Tim family.
genes like me logo Genes that share domains with TIMM10: view

No data available for Gene Families for TIMM10 Gene

Function for TIMM10 Gene

Molecular function for TIMM10 Gene

GENATLAS Biochemistry: translocase of inner mitochondrial membrane 10 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S cerevisiae Tim10p,and essential for escorting a class of multimembrane-spanning proteins
UniProtKB/Swiss-Prot Function: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Gene Ontology (GO) - Molecular Function for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IDA 16387659
GO:0005515 protein binding IPI 14726512
GO:0008270 zinc ion binding TAS 10552927
GO:0008565 protein transporter activity IBA --
GO:0042803 protein homodimerization activity IPI 16387659
genes like me logo Genes that share ontologies with TIMM10: view

Animal Model Products

CRISPR Products

miRNA for TIMM10 Gene

miRTarBase miRNAs that target TIMM10

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIMM10 Gene

Localization for TIMM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM10 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM10 Gene COMPARTMENTS Subcellular localization image for TIMM10 gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005744 mitochondrial inner membrane presequence translocase complex TAS 10552927
GO:0005758 mitochondrial intermembrane space TAS 14726512
GO:0042719 mitochondrial intermembrane space protein transporter complex IDA 14726512
genes like me logo Genes that share ontologies with TIMM10: view

Pathways for TIMM10 Gene

genes like me logo Genes that share pathways with TIMM10: view

Pathways by source for TIMM10 Gene

2 Reactome pathways for TIMM10 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 10552927
GO:0007605 sensory perception of sound TAS 10552927
GO:0044267 cellular protein metabolic process TAS --
GO:0045039 protein import into mitochondrial inner membrane ISS 14726512
GO:0072321 chaperone-mediated protein transport IDA 16387659
genes like me logo Genes that share ontologies with TIMM10: view

Transcripts for TIMM10 Gene

mRNA/cDNA for TIMM10 Gene

Unigene Clusters for TIMM10 Gene

Translocase of inner mitochondrial membrane 10 homolog (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIMM10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for TIMM10 Gene

GeneLoc Exon Structure for
TIMM10
ECgene alternative splicing isoforms for
TIMM10

Expression for TIMM10 Gene

mRNA expression in normal human tissues for TIMM10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM10 Gene

SOURCE GeneReport for Unigene cluster for TIMM10 Gene Hs.235750

mRNA Expression by UniProt/SwissProt for TIMM10 Gene

P62072-TIM10_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
genes like me logo Genes that share expressions with TIMM10: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TIMM10 Gene

Orthologs for TIMM10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM10 35
  • 100 (n)
  • 100 (a)
TIMM10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 78 (a)
OneToMany
TIMM10 35
  • 92.59 (n)
  • 97.78 (a)
TIMM10 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TIMM10 35
  • 94.44 (n)
  • 98.89 (a)
TIMM10 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm10 35
  • 92.59 (n)
  • 100 (a)
Timm10 16
Timm10 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM10 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM10 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm10 35
  • 92.59 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves TIMM10 35
  • 78.89 (n)
  • 87.78 (a)
TIMM10 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIMM10 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23815 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76115 35
timm10 35
  • 77.52 (n)
  • 90.7 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28317 35
timm10 35
  • 73.11 (n)
  • 80.68 (a)
timm10 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010679 35
  • 67.98 (n)
  • 64.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tim10 35
  • 70.18 (n)
  • 71.05 (a)
Tim10 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tin-10 35
  • 63.11 (n)
  • 58.67 (a)
tin-10 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM10 36
  • 33 (a)
OneToOne
TIM10 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1154 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5364 36
  • 57 (a)
OneToOne
Species with no ortholog for TIMM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM10 Gene

ENSEMBL:
Gene Tree for TIMM10 (if available)
TreeFam:
Gene Tree for TIMM10 (if available)

Paralogs for TIMM10 Gene

Selected SIMAP similar genes for TIMM10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIMM10: view

No data available for Paralogs for TIMM10 Gene

Variants for TIMM10 Gene

Sequence variations from dbSNP and Humsavar for TIMM10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs539893 -- 57,530,178(+) GCCCT(A/C/G/T)AGAGG synonymous-codon, reference
rs1798167 -- 57,531,900(+) tatat(G/T)tatct upstream-variant-2KB
rs10547275 -- 57,528,510(+) ATATA(-/TATATATA)CACAT utr-variant-3-prime
rs10792101 -- 57,529,186(+) GCAAT(A/G)CTTAC intron-variant
rs10896623 -- 57,528,391(+) CATTA(A/G)TCTCC downstream-variant-500B

Relevant External Links for TIMM10 Gene

HapMap Linkage Disequilibrium report
TIMM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIMM10 Gene

Disorders for TIMM10 Gene

Relevant External Links for TIMM10

Genetic Association Database (GAD)
TIMM10
Human Genome Epidemiology (HuGE) Navigator
TIMM10
genes like me logo Genes that share disorders with TIMM10: view

No data available for UniProtKB/Swiss-Prot for TIMM10 Gene

Publications for TIMM10 Gene

  1. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer M.F. … Hofmann S. (FEBS Lett. 1999) 3 4 23
  2. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PMID: 10552927) Jin H. … Vetrie D.L.P. (Genomics 1999) 2 3 4
  3. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. (PMID: 11489896) Rothbauer U. … Bauer M.F. (J. Biol. Chem. 2001) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. (PMID: 14726512) Muehlenbein N. … Bauer M.F. (J. Biol. Chem. 2004) 3 4

Products for TIMM10 Gene

Sources for TIMM10 Gene

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