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Aliases for TIMM10 Gene

Aliases for TIMM10 Gene

  • Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast) 2 3 5
  • TIM10 3 4
  • Translocase Of Inner Mitochondrial Membrane 10 (Yeast) Homolog 2
  • TIM10A 3

External Ids for TIMM10 Gene

Previous GeneCards Identifiers for TIMM10 Gene

  • GC11M059689
  • GC11M058809
  • GC11M057546
  • GC11M057071
  • GC11M057052
  • GC11M057296
  • GC11M053644
  • GC11M057299
  • GC11M057531
  • GC11M057534

Summaries for TIMM10 Gene

Entrez Gene Summary for TIMM10 Gene

  • The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIMM10 Gene

TIMM10 (Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. GO annotations related to this gene include protein homodimerization activity and chaperone binding.

UniProtKB/Swiss-Prot for TIMM10 Gene

  • Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Gene Wiki entry for TIMM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM10 Gene

Genomics for TIMM10 Gene

Regulatory Elements for TIMM10 Gene

Promoters for TIMM10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIMM10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIMM10 Gene

Chromosome:
11
Start:
57,528,463 bp from pter
End:
57,530,803 bp from pter
Size:
2,341 bases
Orientation:
Minus strand

Genomic View for TIMM10 Gene

Genes around TIMM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM10 Gene

Proteins for TIMM10 Gene

  • Protein details for TIMM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62072-TIM10_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim10
    Protein Accession:
    P62072
    Secondary Accessions:
    • A8K136
    • Q9WV99
    • Q9WVA0
    • Q9Y5J8

    Protein attributes for TIMM10 Gene

    Size:
    90 amino acids
    Molecular mass:
    10333 Da
    Quaternary structure:
    • Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

    Three dimensional structures from OCA and Proteopedia for TIMM10 Gene

neXtProt entry for TIMM10 Gene

Proteomics data for TIMM10 Gene at MOPED

Post-translational modifications for TIMM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM10 Gene

Domains & Families for TIMM10 Gene

Protein Domains for TIMM10 Gene

Suggested Antigen Peptide Sequences for TIMM10 Gene

Graphical View of Domain Structure for InterPro Entry

P62072

UniProtKB/Swiss-Prot:

TIM10_HUMAN :
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
  • Belongs to the small Tim family.
Domain:
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
Family:
  • Belongs to the small Tim family.
genes like me logo Genes that share domains with TIMM10: view

No data available for Gene Families for TIMM10 Gene

Function for TIMM10 Gene

Molecular function for TIMM10 Gene

GENATLAS Biochemistry:
translocase of inner mitochondrial membrane 10 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S cerevisiae Tim10p,and essential for escorting a class of multimembrane-spanning proteins
UniProtKB/Swiss-Prot Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Gene Ontology (GO) - Molecular Function for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14726512
GO:0008565 protein transporter activity IBA --
GO:0042803 protein homodimerization activity IPI 16387659
genes like me logo Genes that share ontologies with TIMM10: view
genes like me logo Genes that share phenotypes with TIMM10: view

Animal Model Products

CRISPR Products

miRNA for TIMM10 Gene

miRTarBase miRNAs that target TIMM10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM10 Gene

Localization for TIMM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM10 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIMM10 Gene COMPARTMENTS Subcellular localization image for TIMM10 gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 3

Gene Ontology (GO) - Cellular Components for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0042719 mitochondrial intermembrane space protein transporter complex IDA 14726512
genes like me logo Genes that share ontologies with TIMM10: view

Pathways & Interactions for TIMM10 Gene

genes like me logo Genes that share pathways with TIMM10: view

Pathways by source for TIMM10 Gene

2 Reactome pathways for TIMM10 Gene

Gene Ontology (GO) - Biological Process for TIMM10 Gene

None

No data available for SIGNOR curated interactions for TIMM10 Gene

Drugs & Compounds for TIMM10 Gene

No Compound Related Data Available

Transcripts for TIMM10 Gene

mRNA/cDNA for TIMM10 Gene

Unigene Clusters for TIMM10 Gene

Translocase of inner mitochondrial membrane 10 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for TIMM10 Gene

GeneLoc Exon Structure for
TIMM10
ECgene alternative splicing isoforms for
TIMM10

Expression for TIMM10 Gene

mRNA expression in normal human tissues for TIMM10 Gene

Protein differential expression in normal tissues from HIPED for TIMM10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.1), Pancreas (10.9), and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIMM10 Gene



SOURCE GeneReport for Unigene cluster for TIMM10 Gene Hs.235750

mRNA Expression by UniProt/SwissProt for TIMM10 Gene

P62072-TIM10_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
genes like me logo Genes that share expression patterns with TIMM10: view

Protein tissue co-expression partners for TIMM10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TIMM10 Gene

Orthologs for TIMM10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM10 35
  • 100 (n)
  • 100 (a)
TIMM10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 78 (a)
OneToMany
TIMM10 36
  • 98 (a)
OneToMany
TIMM10 35
  • 92.59 (n)
  • 97.78 (a)
dog
(Canis familiaris)
Mammalia TIMM10 35
  • 94.44 (n)
  • 98.89 (a)
TIMM10 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Timm10 36
  • 100 (a)
OneToOne
Timm10 16
Timm10 35
  • 92.59 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia TIMM10 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM10 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Timm10 35
  • 92.59 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves TIMM10 36
  • 87 (a)
OneToOne
TIMM10 35
  • 78.89 (n)
  • 87.78 (a)
lizard
(Anolis carolinensis)
Reptilia TIMM10 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23815 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76115 35
timm10 35
  • 77.52 (n)
  • 90.7 (a)
zebrafish
(Danio rerio)
Actinopterygii timm10 36
  • 80 (a)
OneToOne
Dr.28317 35
timm10 35
  • 73.11 (n)
  • 80.68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010679 35
  • 67.98 (n)
  • 64.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tim10 36
  • 60 (a)
OneToOne
Tim10 35
  • 70.18 (n)
  • 71.05 (a)
worm
(Caenorhabditis elegans)
Secernentea tin-10 35
  • 63.11 (n)
  • 58.67 (a)
tin-10 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM10 36
  • 33 (a)
OneToOne
TIM10 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1154 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5364 36
  • 57 (a)
OneToOne
Species with no ortholog for TIMM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM10 Gene

ENSEMBL:
Gene Tree for TIMM10 (if available)
TreeFam:
Gene Tree for TIMM10 (if available)

Paralogs for TIMM10 Gene

(1) SIMAP similar genes for TIMM10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIMM10: view

No data available for Paralogs for TIMM10 Gene

Variants for TIMM10 Gene

Sequence variations from dbSNP and Humsavar for TIMM10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10547275 -- 57,528,510(+) ATATA(-/TATATATA)CACAT utr-variant-3-prime
rs10792101 -- 57,529,186(+) GCAAT(A/G)CTTAC intron-variant
rs10896623 -- 57,528,391(+) CATTA(A/G)TCTCC downstream-variant-500B
rs58460878 -- 57,528,512(+) ATATA(-/TATATA)CACAT cds-indel
rs35915913 -- 57,531,052(+) CCTCA(-/C)CCCCC upstream-variant-2KB

Variation tolerance for TIMM10 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIMM10 Gene

HapMap Linkage Disequilibrium report
TIMM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIMM10 Gene

Disorders for TIMM10 Gene

Relevant External Links for TIMM10

Genetic Association Database (GAD)
TIMM10
Human Genome Epidemiology (HuGE) Navigator
TIMM10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIMM10

No disorders were found for TIMM10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM10 Gene

Publications for TIMM10 Gene

  1. The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. (PMID: 10552927) Jin H. … Vetrie D.L.P. (Genomics 1999) 2 3 4 67
  2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer M.F. … Hofmann S. (FEBS Lett. 1999) 3 23
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for TIMM10 Gene

Sources for TIMM10 Gene

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