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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMELESS Gene

protein-coding   GIFtS: 57
GCID: GC12M056810

Timeless Circadian Clock

(Previous names: timeless (Drosophila) homolog, timeless homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Timeless Circadian Clock1 2     Timeless Homolog (Drosophila)1
TIM2 3 5     Tof1 Homolog (S. Cerevisiae)1
TIM12 3 5     Protein Timeless Homolog2
Timeless Circadian Clock 11 2     Timeless Homolog2
hTIM2 3     Tof1 Homolog2
Timeless (Drosophila) Homolog1     TIMELESS13

External Ids:    HGNC: 118131   Entrez Gene: 89142   Ensembl: ENSG000001116027   OMIM: 6038875   UniProtKB: Q9UNS13   

Export aliases for TIMELESS gene to outside databases

Previous GC identifers: GC12P056609 GC12M057034 GC12M056526 GC12M055097 GC12M053849


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TIMELESS Gene: 
TIMELESS (timeless circadian clock) is a protein-coding gene. Diseases associated with TIMELESS include vestibular nystagmus, and pellagra. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1
Function: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop.
Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into
the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication
stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by
hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation
of branching tubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMELESS gene promoter:
         Sp1   AP-2alpha isoform 3   ATF-2   AP-2alpha isoform 2   Max   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMELESS promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMELESS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMELESS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

TIMELESS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMELESS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056810:  view genomic region     (about GC identifiers)

Start:
56,810,157 bp from pter      End:
56,843,200 bp from pter
Size:
33,044 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1 (See protein sequence)
Recommended Name: Protein timeless homolog  
Size: 1208 amino acids; 138658 Da
Subunit: Homomultimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or
NPAS2, BMAL1 or BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1, PER2
and PER3. Interacts with PER2 via its second PAS domain in vitro. Binds CRY1, CRY2, CHEK1, ATR and ATRIP (By
similarity). Interacts with TIPIN and CLSPN
Subcellular location: Nucleus
Sequence caution: Sequence=AAH39842.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: B2ZAV0 O94802 Q86VM1 Q8IWH3
Alternative splicing: 2 isoforms:  Q9UNS1-1   Q9UNS1-2   

Explore the universe of human proteins at neXtProt for TIMELESS: NX_Q9UNS1

Explore proteomics data for TIMELESS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNS1

  • TIMELESS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMELESS Protein Expression
    REFSEQ proteins: NP_003911.2  
    ENSEMBL proteins: 
     ENSP00000229201   ENSP00000450607   ENSP00000450848  

    Human Recombinant Protein Products for TIMELESS: 
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    OriGene Purified Protein for TIMELESS
    OriGene Protein Over-expression Lysate for TIMELESS
    OriGene MassSpec for TIMELESS 
    OriGene Custom Protein Services for TIMELESS
    GenScript Custom Purified and Recombinant Proteins Services for TIMELESS
    Novus Biologicals TIMELESS Protein
    Novus Biologicals TIMELESS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA17102137
    GO:0005634nucleus IDA17102137

    TIMELESS for ontologies           About GeneDecksing



    TIMELESS Antibody Products: 
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    Abcam antibodies for TIMELESS
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for TIMELESS
    LSBio Antibodies in human, mouse, rat for TIMELESS 

    Assay Products for TIMELESS: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007725 TIMELESS_C
     IPR006906 Timeless

    Graphical View of Domain Structure for InterPro Entry Q9UNS1

    ProtoNet protein and cluster: Q9UNS1

    1 Blocks protein domain: IPB006906 Timeless protein

    UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1
    Similarity: Belongs to the timeless family


    TIMELESS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM_HUMAN, Q9UNS1
    Function: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop.
    Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into
    the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication
    stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by
    hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation
    of branching tubules
    Induction: Regulated by the cell cycle. High levels in S, G(2) and M phases, with highest level in S phase. Low
    expression in G(0) and G(1) phases

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15798197
    GO:0042803protein homodimerization activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TIMELESS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TIMELESS:
     Increased S DNA content, incre  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Timeless):
     mortality/aging  no phenotypic analysis 

    TIMELESS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TIMELESS: Timelesstm1Jt Timelesstm1Rep

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMELESS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMELESS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMELESS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMELESS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMELESS
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMELESS:
    hsa-miR-483-3p hsa-miR-548a-3p hsa-miR-1224-3p hsa-miR-3662 hsa-miR-548e hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidTIMELESS 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for TIMELESS
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TIMELESS (see all 11)
    OriGene ORF clones in mouse, rat for TIMELESS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMELESS (NM_003920)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMELESS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMELESS
    Sirion Biotech Customized lentivirus for stable overexpression of TIMELESS 
                         Customized lentivirus expression plasmids for stable overexpression of TIMELESS 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMELESS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TIMELESS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Circadian rhythm pathway
    Circadian rhythm pathway


    1 BioSystems Pathway for TIMELESS
        Circadian rhythm pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMELESS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for TIMELESS (Q9UNS11, 3 ENSP000002292014) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK1O147571, 3, ENSP000002789164EBI-2212315,EBI-974488 I2D: score=3 STRING: ENSP00000278916
    PER2O150553, ENSP000002546574I2D: score=4 STRING: ENSP00000254657
    CRY2Q49AN03, ENSP000004067514I2D: score=3 STRING: ENSP00000406751
    CLSPNQ9HAW43, ENSP000003129954I2D: score=1 STRING: ENSP00000312995
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002009morphogenesis of an epithelium ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006974response to DNA damage stimulus IEA--
    GO:0007067mitosis IEA--

    TIMELESS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMELESS (TIM)

    Search CenterWatch for drugs/clinical trials and news about TIMELESS / TIM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMELESS gene: 
    NM_003920.3  

    Unigene Cluster for TIMELESS:

    Timeless circadian clock
    Hs.118631  [show with all ESTs]
    Unigene Representative Sequence: NM_003920
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229201(uc001slf.2 uc001slg.2) ENST00000553532 ENST00000557589
    ENST00000554616 ENST00000553314 ENST00000555808
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMELESS
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TIMELESS:
    hsa-miR-483-3p hsa-miR-548a-3p hsa-miR-1224-3p hsa-miR-3662 hsa-miR-548e hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidTIMELESS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMELESS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMELESS
    Clone
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    OriGene clones in human, mouse for TIMELESS (see all 11)
    OriGene ORF clones in mouse, rat for TIMELESS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMELESS (NM_003920)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMELESS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMELESS
    Sirion Biotech Customized lentivirus for stable overexpression of TIMELESS 
                         Customized lentivirus expression plasmids for stable overexpression of TIMELESS 
    Primer
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    OriGene qPCR primer pairs and template standards for TIMELESS
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMELESS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMELESS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMELESS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMELESS

    Additional mRNA sequence: 

    AB015597.1 AF098162.1 AK000721.1 AK022702.1 AK296869.1 BC031514.1 BC039842.1 BC050557.1 

    6 DOTS entries:

    DT.309306  DT.91690397  DT.100042356  DT.100785401  DT.92439590  DT.95209610 

    24/294 AceView cDNA sequences (see all 294):

    AW769136 BU685029 CA422437 AW167047 AI969152 AW189438 BM824810 BQ961203 
    AW675811 AI494276 BE793649 AI887884 CR596590 BU521442 AI333322 BM910771 
    BU552412 BE170974 BC031514 BQ679254 NM_003920 BM740568 BM764369 AA809127 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TIMELESS (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -     -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29
    SP1:                                                                                                                  
    SP2:                    -                       -                             -                                       
    SP3:                    -                                                     -                                       
    SP4:                    -                       -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for TIMELESS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMELESS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGATTAGA
    TIMELESS Expression
    About this image


    See TIMELESS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMELESS

    SOURCE GeneReport for Unigene cluster: Hs.118631

    UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1
    Tissue specificity: Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle,
    kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus
    and testis

        SABiosciences Expression via Pathway-Focused PCR Array including TIMELESS: 
              Circadian Rhythms in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TIMELESS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMELESS
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMELESS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMELESS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TIMELESS gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timeless1 , 5 timeless homolog (Drosophila)1, 5 83.14(n)1
    84.59(a)1
      10 (76.49 cM)5
    218531  NM_011589.21  NP_035719.11 
     1282320655 
    chicken
    (Gallus gallus)
    Aves --
    --
    --
    62(a)
    41(a)
    many → 1
    many → 1
    AADN03014486.1(21-984)
    AADN03013001.1(223-1462)
    lizard
    (Anolis carolinensis)
    Reptilia TIMELESS6
    timeless circadian clock
    65(a)
    1 ↔ 1
    2(93222426-93291002)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.296132 Xenopus laevis transcribed sequence with weak similarity more 74.19(n)    BU912250.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fd23d071 wu:fd23d07 62.4(n)
    62.46(a)
      325855  XM_003199412.1  XP_003199460.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta timeout1 , 3 CG7855-PA1 33(a)3
    46.53(n)1
    34.9(a)1
      416151  NM_079617.31  NP_524341.31 
    worm
    (Caenorhabditis elegans)
    Secernentea Y75B8A.223   -- 28(a)   III(12312119-12321798)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOF16
    Subunit of a replication-pausing checkpoint comple...
    11(a)
    1 ↔ 1
    XIV(122883-126599)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATIM1 timeless family protein 40.79(n)
    27.3(a)
      835368  NM_124669.2  NP_200103.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g02105001 hypothetical protein 39.71(n)
    28.1(a)
      4338095  NM_001061450.1  NP_001054915.1 


    ENSEMBL Gene Tree for TIMELESS (if available)
    TreeFam Gene Tree for TIMELESS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMELESS gene
    1 SIMAP similar gene for TIMELESS using alignment to 2 protein entries:     TIM_HUMAN (see all proteins):
    DKFZp686H09231

    TIMELESS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1053 SNPs in TIMELESS are shown (see all 1053)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364354
    A breast cancer sample4--see VAR_0364352 A D mis40--------
    VAR_0364364
    A breast cancer sample4--see VAR_0364362 Q E mis40--------
    rs589571071,2
    C--56668180(+) TTTTT-/TTT   
       
    /TTTT
    GAGAC
    2 -- int1 cds11NA 2
    rs1164915211,2
    C,F--56809711(+) ATTTGC/TGGGGC 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1808448081,2
    --56809805(+) GAGCCA/GAGATC 1 -- int10--------
    rs671065911,2
    C--56809857(+) AAAAAA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1386242881,2
    C--56809925(+) AGCCCA/GGATCA 1 -- int10--------
    rs1493289931,2
    --56809937(+) GGAGGC/GAAAAC 1 -- int10--------
    rs26436291,2
    C,F,A,H--56809993(-) TGAGCC/TTTTCT 1 -- int128Minor allele frequency- T:0.06NS EA NA WA CSA 2130
    rs26436281,2
    C,F--56810008(-) GGTGTC/GTCTTC 1 -- int17Minor allele frequency- G:0.12WA CSA NA EA 365

    HapMap Linkage Disequilibrium report for TIMELESS (56810157 - 56843200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TIMELESS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745927CNV Deletion23290073
    nsv482992CNV Complex15286789

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMELESS
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603887    OMIM disorders: --

    19 diseases for TIMELESS:    About MalaCards
    vestibular nystagmus    pellagra    mental disorders    bipolar i disorder
    schizoaffective disorder    allergic asthma    smallpox    mood disorder
    bipolar disorder    cholera    asthma    dementia
    alcoholism    schizophrenia    rheumatoid arthritis    arthritis
    hepatocellular carcinoma    prostatitis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for TIMELESS:
    Vestibular nystagmus     Pellagra

    TIMELESS for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIMELESS
    Human Genome Epidemiology (HuGE) Navigator: TIMELESS (20 documents)

    Export disorders for TIMELESS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMELESS gene, integrated from 9 sources (see all 99):
    (articles sorted by number of sources associating them with TIMELESS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. (PubMed id 9856465)1, 2, 3 Sangoram A.M.... Takahashi J.S. (1998)
    2. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. (PubMed id 17102137)1, 2, 9 Yoshizawa-Sugata N. and Masai H. (2007)
    3. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CL OCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4, 9 Soria V....Urretavizcaya M. (2010)
    4. Circadian clock gene polymorphisms in alcohol use dis orders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (2010)
    5. Systematic analysis of circadian genes in a populatio n-based sample reveals association of TIMELESS with depression and sleep distur bance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. PER2 variantion is associated with depression vulnera bility. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Testing the circadian gene hypothesis in prostate can cer: a population-based case-control study. (PubMed id 19934327)1, 4 Zhu Y....Stanford J.L. (2009)
    10. NPAS2 and PER2 are linked to risk factors of the meta bolic syndrome. (PubMed id 19470168)1, 4 Englund A....Partonen T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8914 HGNC: 11813 AceView: TIMELESS Ensembl:ENSG00000111602 euGenes: HUgn8914
    ECgene: TIMELESS H-InvDB: TIMELESS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMELESS Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/timeless/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMELESS gene:
    Search GeneIP for patents involving TIMELESS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Regulatory tfbs in TIMELESS promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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