TIMELESS Gene
protein-coding GIFtS: 57
GCID: GC12M056810
|
|
timeless circadian clock(Previous names: timeless (Drosophila) homolog, timeless homolog (Drosophila)...)
| |
Aliases for TIMELESS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Timeless Circadian Clock1 2 | | Protein Timeless Homolog2 | | TIM1 2 3 5 | | Timeless Circadian Clock 12 | | TIM11 2 3 5 | | Timeless Homolog2 | | HTIM1 | | Tof1 Homolog2 | | Timeless (Drosophila) Homolog1 | | TIMELESS13 | | Timeless Homolog (Drosophila)1 | | |
Export aliases for TIMELESS gene to outside databasesPrevious GC identifers: GC12P056609 GC12M057034 GC12M056526 GC12M055097 GC12M053849 |
Summaries for TIMELESS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1Function: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negativelyregulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus.Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May bespecifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultravioletlight. May also play an important role in epithelial cell morphogenesis and formation of branching tubules
|
Genomic Views for TIMELESS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TIMELESS gene promoter: Sp1 AP-2alpha isoform 3 ATF-2 AP-2alpha isoform 2 Max AP-2alpha isoform 4 AP-2alpha AP-2alphaA c-Myc Other transcription factors
Search SABiosciences Chromatin IP Primers for TIMELESS
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMELESS |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3TIMELESS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M056810: view genomic region
(about GC identifiers)
Start:
|
56,810,157 bp from pter |
End:
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56,843,200 bp from pter |
Size:
|
33,044 bases |
Orientation:
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minus strand |
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Proteins for TIMELESS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1 (See
protein sequence)Recommended Name: Protein timeless homolog Size: 1208 amino acids; 138658 Da
Subunit: Homomultimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2,BMAL1 or BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1, PER2 and PER3.Interacts with PER2 via its second PAS domain in vitro. Binds CRY1, CRY2, CHEK1, ATR and ATRIP (By similarity).Interacts with TIPIN and CLSPN
Subcellular location: Nucleus
Sequence caution: Sequence=AAH39842.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: B2ZAV0 O94802 Q86VM1 Q8IWH3Alternative splicing: 2 isoforms: Q9UNS1-1 Q9UNS1-2 Explore the universe of human proteins at neXtProt for TIMELESS: NX_Q9UNS1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UNS1 TIMELESS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003911.2 ENSEMBL proteins: ENSP00000229201 ENSP00000450607 ENSP00000450848 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TIMELESS for ontologies About GeneDecksing
TIMELESS Antibody Products: Assay Products for TIMELESS: |
Protein
Domains / Families for TIMELESS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIMELESS for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UNS1ProtoNet protein and cluster: Q9UNS1 1 Blocks protein family: IPB006906 Timeless protein
UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1Similarity: Belongs to the timeless family |
Function for TIMELESS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1Function: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negativelyregulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus.Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May bespecifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultravioletlight. May also play an important role in epithelial cell morphogenesis and formation of branching tubulesInduction: Regulated by the cell cycle. High levels in S, G(2) and M phases, with highest level in S phase. Lowexpression in G(0) and G(1) phases
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMELESS (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMELESS OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TIMELESS (NM_003920) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIMELESS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMELESS  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMELESS |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TIMELESS for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TIMELESS: Animal Models: Mouse knock-outs for TIMELESS: Timelesstm1Jt Timelesstm1Rep 2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Timeless):
TIMELESS for phenotypes About GeneDecksing
|
Pathways & Interactions for TIMELESS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Circadian rhythm pathway | |
1 BioSystems Pathway for TIMELESS 
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIMELESS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/29 Interacting proteins for TIMELESS (Q9UNS11, 3 ENSP000002292014) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0002009 | morphogenesis of an epithelium |
ISS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006974 | response to DNA damage stimulus |
IEA | -- | | GO:0007067 | mitosis |
IEA | -- |
TIMELESS for ontologies About GeneDecksing
|
Drugs & Compounds for TIMELESS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TIMELESS Search CenterWatch for drugs/clinical trials and news about TIMELESS / TIM 
|
Transcripts for TIMELESS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TIMELESS gene: NM_003920.3 Unigene Cluster for TIMELESS: Timeless circadian clock Hs.118631 [show with all ESTs]Unigene Representative Sequence: NM_0039206 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000229201(uc001slf.2 uc001slg.2) ENST00000553532 ENST00000557589 ENST00000554616 ENST00000553314 ENST00000555808
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMELESS (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMELESS OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TIMELESS (NM_003920) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIMELESS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMELESS  |
Additional cDNA sequence: AB015597.1 AF098162.1 AK000721.1 AK022702.1 AK296869.1 BC031514.1 BC039842.1 BC050557.1 6 DOTS entries: DT.309306 DT.91690397 DT.100042356 DT.100785401 DT.92439590 DT.95209610 24/294 AceView cDNA sequences (see all 294): AA115381 CA777183 BM765603 BQ679251 BU552412 BQ961203 AK022702 BX110927 AW769136 AW189438 BQ895708 AI417732 BQ679317 BQ927468 CA776900 BC031514 AI559688 AI969152 AA417857 BM764369 BU543485 BQ672871 BE170974 CR624744 GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TIMELESS (see all 13) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d | ^ | 18a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TIMELESS
|
Expression for TIMELESS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIMELESS expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAAGATTAGA
About this image See TIMELESS Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TIMELESS
SOURCE GeneReport for Unigene cluster: Hs.118631 UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1Tissue specificity: Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney,placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis SABiosciences Expression via Pathway-Focused PCR Array including TIMELESS:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMELESS Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMELESS | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMELESS | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMELESS | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMELESS |
Orthologs for TIMELESS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TIMELESS gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Timeless1 , 5 |
timeless homolog (Drosophila)1, 5 |
83.14(n)1 84.59(a)1 |
  |
10 (76.49 cM)5 218531 NM_011589.21 NP_035719.11 1282320655 |
lizard (Anolis carolinensis) |
Reptilia |
TIMELESS6 |
-- |
66(a) |
1 ↔ 1 |
2(93257515-93290993) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.296132 |
Xenopus laevis transcribed sequence with weak similarity more |
74.19(n) |
  |
BU912250.1 |
zebrafish (Danio rerio) |
Actinopterygii |
wu:fd23d071 |
wu:fd23d07 |
62.4(n) 62.46(a) |
  |
325855 XM_003199412.1 XP_003199460.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
timeout1 , 3 |
CG7855-PA1 |
33(a)3 46.53(n)1 34.9(a)1 |
  |
416151 NM_079617.31 NP_524341.31 |
worm (Caenorhabditis elegans) |
Secernentea |
Y75B8A.223 |
-- |
28(a) |
  |
III(12312119-12321798) -- |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
ATIM1 |
timeless family protein |
40.79(n) 27.3(a) |
  |
835368 NM_124669.2 NP_200103.1 |
rice (Oryza sativa) |
Liliopsida |
Os05g02105001 |
hypothetical protein |
39.71(n) 28.1(a) |
  |
4338095 NM_001061450.1 NP_001054915.1 |
ENSEMBL Gene Tree for TIMELESS (if available) TreeFam Gene Tree for TIMELESS (if available)  |
Paralogs for TIMELESS gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for TIMELESS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TIMELESS (56810157 - 56843200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TIMELESS 1 CNV: 0164  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMELESS |
|
Disorders
/ Diseases for TIMELESS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TIMELESS for disorders About GeneDecksing
OMIM gene information: 603887
OMIM disorders: --
19 diseases for TIMELESS: About MalaCardsvestibular nystagmus bipolar i disorder schizoaffective disorder allergic asthma mood disorder mental disorders nystagmus bipolar disorder rheumatoid arthritis asthma cholera hepatocellular carcinoma arthritis dementia breast carcinoma carcinoma schizophrenia prostatitis alcoholism 2 diseases from the University of Copenhagen DISEASES database for TIMELESS:Vestibular nystagmus Pellagra Genetic Association Database (GAD): TIMELESS Human Genome Epidemiology (HuGE) Navigator: TIMELESS (20 documents) Export disorders for TIMELESS gene to outside databases
|
Publications for TIMELESS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIMELESS gene, integrated from 9 sources (see all 91): (articles sorted by number of sources associating them with TIMELESS) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. (PubMed id 9856465)1, 2, 3 Sangoram A.M.... Takahashi J.S. (1998)
- Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. (PubMed id 17102137)1, 2, 9 Yoshizawa-Sugata N. and Masai H. (2007)
- The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. (PubMed id 17296725)1, 2 Uensal-Kacmaz K.... Kaufmann W.K. (2007)
- Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. (PubMed id 17141802)1, 2 Gotter A.L.... Emanuel B.S. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. (PubMed id 17116885)1, 2 Chou D.M. and Elledge S.J. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Coupling of human circadian and cell cycles by the timeless protein. (PubMed id 15798197)1, 2 Uensal-Kacmaz K.... Sancar A. (2005)
- The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population. (PubMed id 15565336)1, 4 Chae S.C....Chung H.T. (2005)
- The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population. (PubMed id 14985107)1, 4 Chae S.C....Chung H.T. (2004)
|
External Searches for TIMELESS gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TIMELESS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIMELESS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIMELESS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TIMELESS | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/timeless/ |
|
| | |
About This Section
| Patent Information for TIMELESS gene: Search GeneIP for patents involving TIMELESS
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for TIMELESS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | OriGene Antibodies for TIMELESS | | OriGene shRNA RFP for TIMELESS | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIMELESS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIMELESS | | OriGene Protein Over-expression Lysate for TIMELESS | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for TIMELESS | | OriGene 3'-UTR Clone for TIMELESS | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIMELESS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIMELESS | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for TIMELESS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for TIMELESS | | OriGene Custom Protein Services for TIMELESS | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMELESS | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIMELESS | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMELESS | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMELESS | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMELESS | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMELESS |
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 | | TIMELESS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMELESS |
|  |  |  | | | Search ThermoFisher Antibodies for TIMELESS |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMELESS |
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