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TIMELESS Gene

protein-coding   GIFtS: 58
GCID: GC12M056810

Timeless Circadian Clock

(Previous names: timeless (Drosophila) homolog, timeless homolog (Drosophila))
  See TIMELESS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Timeless Circadian Clock1 2     Timeless Homolog (Drosophila)1
TIM2 3 5     Tof1 Homolog (S. Cerevisiae)1
TIM12 3 5     Protein Timeless Homolog2
Timeless Circadian Clock 11 2     Timeless Homolog2
hTIM2 3     Tof1 Homolog2
Timeless (Drosophila) Homolog1     TIMELESS13

External Ids:    HGNC: 118131   Entrez Gene: 89142   Ensembl: ENSG000001116027   OMIM: 6038875   UniProtKB: Q9UNS13   

Export aliases for TIMELESS gene to outside databases

Previous GC identifers: GC12P056609 GC12M057034 GC12M056526 GC12M055097 GC12M053849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIMELESS Gene:
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress,
increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis.
The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD
genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene
or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. (provided by
RefSeq, Feb 2014)

GeneCards Summary for TIMELESS Gene:
TIMELESS (timeless circadian clock) is a protein-coding gene. Diseases associated with TIMELESS include vestibular nystagmus, and pellagra. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1
Function: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop.
Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into
the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication
stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by
hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation
of branching tubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIMELESS gene promoter:
         Sp1   AP-2alpha isoform 3   ATF-2   AP-2alpha isoform 2   Max   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMELESS promoter sequence
   Search Chromatin IP Primers for TIMELESS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMELESS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

TIMELESS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMELESS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056810:  view genomic region     (about GC identifiers)

Start:
56,810,157 bp from pter      End:
56,843,200 bp from pter
Size:
33,044 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1 (See protein sequence)
Recommended Name: Protein timeless homolog  
Size: 1208 amino acids; 138658 Da
Subunit: Homomultimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or
NPAS2, BMAL1 or BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1, PER2
and PER3. Interacts with PER2 via its second PAS domain in vitro. Binds CRY1, CRY2, CHEK1, ATR and ATRIP (By
similarity). Interacts with TIPIN and CLSPN
Sequence caution: Sequence=AAH39842.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: B2ZAV0 O94802 Q86VM1 Q8IWH3
Alternative splicing: 2 isoforms:  Q9UNS1-1   Q9UNS1-2   

Explore the universe of human proteins at neXtProt for TIMELESS: NX_Q9UNS1

Explore proteomics data for TIMELESS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys288, Lys299
  • Modification sites at PhosphoSitePlus

  • See TIMELESS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003911.2  
    ENSEMBL proteins: 
     ENSP00000229201   ENSP00000450607   ENSP00000450848  

    TIMELESS Human Recombinant Protein Products:

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    OriGene Purified Protein for TIMELESS
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    Novus Biologicals TIMELESS Protein
    Novus Biologicals TIMELESS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TIMELESS 

    TIMELESS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TIMELESS Antibodies
    Search for Antibodies for TIMELESS at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TIMELESS
    LSBio Antibodies in human, mouse, rat for TIMELESS

    TIMELESS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIMELESS
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TIMELESS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007725 TIMELESS_C
     IPR006906 Timeless

    Graphical View of Domain Structure for InterPro Entry Q9UNS1

    ProtoNet protein and cluster: Q9UNS1

    1 Blocks protein domain: IPB006906 Timeless protein

    UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1
    Similarity: Belongs to the timeless family


    Find genes that share domains with TIMELESS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIM_HUMAN, Q9UNS1
    Function: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop.
    Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into
    the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication
    stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by
    hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation
    of branching tubules
    Induction: Regulated by the cell cycle. High levels in S, G(2) and M phases, with highest level in S phase. Low
    expression in G(0) and G(1) phases

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15798197
    GO:0042803protein homodimerization activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with TIMELESS           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TIMELESS:
     Increased S DNA content, incre  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Timeless):
     mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with TIMELESS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TIMELESS: Timelesstm1Jt Timelesstm1Rep

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIMELESS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIMELESS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMELESS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMELESS

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIMELESS:
    hsa-mir-324-5p (MIRT043049), hsa-mir-615-3p (MIRT039980), hsa-mir-484 (MIRT041838), hsa-mir-320b (MIRT036201), hsa-mir-877-3p (MIRT036827), hsa-mir-183-5p (MIRT047095)

    Block miRNA regulation of human, mouse, rat TIMELESS using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TIMELESS:
    hsa-miR-483-3p hsa-miR-548a-3p hsa-miR-1224-3p hsa-miR-3662 hsa-miR-548e hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidTIMELESS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIMELESS
    Predesigned siRNA for gene silencing in human, mouse, rat TIMELESS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TIMELESS

    Clone
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    OriGene clones in human, mouse for TIMELESS (see all 11)
    OriGene ORF clones in mouse, rat for TIMELESS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMELESS (NM_003920)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMELESS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMELESS
    Addgene plasmids for TIMELESS 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TIMELESS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMELESS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIM_HUMAN, Q9UNS1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA17102137
    GO:0005634nucleus IDA17102137

    Find genes that share ontologies with TIMELESS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TIMELESS About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian rhythm pathway
    Circadian rhythm pathway


    1 BioSystems Pathway for TIMELESS
        Circadian rhythm pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including TIMELESS: 
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TIMELESS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIMELESS (Q9UNS11, 3 ENSP000002292014) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK1O147571, 3, ENSP000002789164EBI-2212315,EBI-974488 I2D: score=3 STRING: ENSP00000278916
    PER2O150553, ENSP000002546574I2D: score=4 STRING: ENSP00000254657
    CRY2Q49AN03, ENSP000004067514I2D: score=3 STRING: ENSP00000406751
    CLSPNQ9HAW43, ENSP000003129954I2D: score=1 STRING: ENSP00000312995
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002009morphogenesis of an epithelium ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006974cellular response to DNA damage stimulus IEA--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with TIMELESS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIMELESS (TIM)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIMELESS gene: 
    NM_003920.3  

    Unigene Cluster for TIMELESS:

    Timeless circadian clock
    Hs.118631  [show with all ESTs]
    Unigene Representative Sequence: NM_003920
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229201(uc001slf.2 uc001slg.2) ENST00000553532 ENST00000557589
    ENST00000554616 ENST00000553314 ENST00000555808
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TIMELESS using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TIMELESS:
    hsa-miR-483-3p hsa-miR-548a-3p hsa-miR-1224-3p hsa-miR-3662 hsa-miR-548e hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidTIMELESS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TIMELESS
    Predesigned siRNA for gene silencing in human, mouse, rat TIMELESS
    Clone
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    OriGene clones in human, mouse for TIMELESS (see all 11)
    OriGene ORF clones in mouse, rat for TIMELESS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIMELESS (NM_003920)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMELESS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMELESS
    Addgene plasmids for TIMELESS 
    Primer
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    OriGene qPCR primer pairs and template standards for TIMELESS
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMELESS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMELESS
      QuantiTect SYBR Green Assays in human, mouse, rat TIMELESS
      QuantiFast Probe-based Assays in human, mouse, rat TIMELESS

    Additional mRNA sequence: 

    AB015597.1 AF098162.1 AK000721.1 AK022702.1 AK296869.1 BC031514.1 BC039842.1 BC050557.1 

    6 DOTS entries:

    DT.309306  DT.91690397  DT.100042356  DT.100785401  DT.92439590  DT.95209610 

    Selected AceView cDNA sequences (see all 294):

    BE300827 AI559688 AW512259 BQ683360 BE170974 BM474905 BQ958679 BM696254 
    BF971197 AA115381 BQ961203 AW189438 BU172010 CD675572 BM670187 AW275265 
    BQ679254 AF098162 AK022702 BU163559 BU521442 BM467715 AI283089 BM666977 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TIMELESS (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -     -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29
    SP1:                                                                                                                  
    SP2:                    -                       -                             -                                       
    SP3:                    -                                                     -                                       
    SP4:                    -                       -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for TIMELESS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIMELESS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGATTAGA
    TIMELESS Expression
    About this image


    TIMELESS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Brain (Nervous System)
             Hippocampus
    TIMELESS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIMELESS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118631

    UniProtKB/Swiss-Prot: TIM_HUMAN, Q9UNS1
    Tissue specificity: Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle,
    kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus
    and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including TIMELESS: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TIMELESS
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMELESS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMELESS
    QuantiTect SYBR Green Assays in human, mouse, rat TIMELESS
    QuantiFast Probe-based Assays in human, mouse, rat TIMELESS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMELESS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TIMELESS gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timeless1 , 5 timeless homolog (Drosophila)5
    timeless circadian clock 11
    82.61(n)1
    83.75(a)1
      10 (76.49 cM)5
    218531  NM_011589.21  NP_035719.11 
     1282320655 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    64(a)
    23(a)
    many → 1
    many → 1
    AADN03014486.1(21-984)
    AADN03013001.1(223-1462)
    lizard
    (Anolis carolinensis)
    Reptilia TIMELESS6
    timeless circadian clock
    64(a)
    1 ↔ 1
    2(93222426-93291002)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.296132 Xenopus laevis transcribed sequence with weak similarity more 74.19(n)    BU912250.1 
    zebrafish
    (Danio rerio)
    Actinopterygii timeless1 timeless homolog (Drosophila) 63.71(n)
    65.02(a)
      325855  NM_001278600.1  NP_001265529.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta timeout1 , 3 timeout1 33(a)3
    47.47(n)1
    36.53(a)1
      416151  NM_079617.31  NP_524341.31 
    worm
    (Caenorhabditis elegans)
    Secernentea Y75B8A.223   -- 28(a)   III(12312119-12321798)   --


    ENSEMBL Gene Tree for TIMELESS (if available)
    TreeFam Gene Tree for TIMELESS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIMELESS gene
    1 SIMAP similar gene for TIMELESS using alignment to 2 protein entries:     TIM_HUMAN (see all proteins):
    DKFZp686H09231

    Find genes that share paralogs with TIMELESS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIMELESS (see all 1053)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364354
    A breast cancer sample4--see VAR_0364352 A D mis40--------
    VAR_0364364
    A breast cancer sample4--see VAR_0364362 Q E mis40--------
    rs589571071,2
    C--56668180(+) TTTTT-/TTT   
       
    /TTTT
    GAGAC
    2 -- int1 cds11NA 2
    rs1164915211,2
    C,F--56809711(+) ATTTGC/TGGGGC 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1808448081,2
    --56809805(+) GAGCCA/GAGATC 1 -- int10--------
    rs671065911,2
    C--56809857(+) AAAAAA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1386242881,2
    C--56809925(+) AGCCCA/GGATCA 1 -- int10--------
    rs1493289931,2
    --56809937(+) GGAGGC/GAAAAC 1 -- int10--------
    rs26436291,2
    C,F,A,H--56809993(-) TGAGCC/TTTTCT 1 -- int128Minor allele frequency- T:0.06NS EA NA WA CSA 2130
    rs26436281,2
    C,F--56810008(-) GGTGTC/GTCTTC 1 -- int17Minor allele frequency- G:0.12WA CSA NA EA 365

    HapMap Linkage Disequilibrium report for TIMELESS (56810157 - 56843200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TIMELESS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745927CNV Deletion23290073
    nsv482992CNV Complex15286789

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMELESS
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMELESS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603887    OMIM disorders: --

    5 diseases for TIMELESS:    
    About MalaCards
    vestibular nystagmus    pellagra    lung cancer    prostate cancer
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for TIMELESS:
    Vestibular nystagmus     Pellagra

    Find genes that share disorders with TIMELESS           About GenesLikeMe

    Genetic Association Database (GAD): TIMELESS
    Human Genome Epidemiology (HuGE) Navigator: TIMELESS (20 documents)

    Export disorders for TIMELESS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIMELESS gene, integrated from 10 sources (see all 101):
    (articles sorted by number of sources associating them with TIMELESS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. (PubMed id 9856465)1, 2, 3 Sangoram A.M.... Takahashi J.S. (Neuron 1998)
    2. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. (PubMed id 17102137)1, 2, 9 Yoshizawa-Sugata N. and Masai H. (J. Biol. Chem. 2007)
    3. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4, 9 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    4. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (Alcohol Alcohol. 2010)
    5. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (PLoS ONE 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. PER2 variantion is associated with depression vulnerability. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PubMed id 19934327)1, 4 Zhu Y....Stanford J.L. (Cancer Res. 2009)
    10. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. (PubMed id 19470168)1, 4 Englund A....Partonen T. (J Circadian Rhythms 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8914 HGNC: 11813 AceView: TIMELESS Ensembl:ENSG00000111602 euGenes: HUgn8914
    ECgene: TIMELESS H-InvDB: TIMELESS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIMELESS Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/timeless/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIMELESS gene:
    Search GeneIP for patents involving TIMELESS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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