Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIMD4 Gene

protein-coding   GIFtS: 49
GCID: GC05M156278

T-Cell Immunoglobulin And Mucin Domain Containing 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Cell Immunoglobulin And Mucin Domain Containing 41 2     T-Cell Membrane Protein 42 3
TIM-42 3     SMUCKLER2
TIM42 3     T-Cell Immunoglobulin And Mucin Domain-Containing Protein 42
TIMD-42 3     T-Cell Immunoglobulin Mucin Receptor 42

External Ids:    HGNC: 251321   Entrez Gene: 919372   Ensembl: ENSG000001458507   OMIM: 6100965   UniProtKB: Q96H153   

Export aliases for TIMD4 gene to outside databases

Previous GC identifer: GC05M151439


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TIMD4 Gene: 
TIMD4 (T-cell immunoglobulin and mucin domain containing 4) is a protein-coding gene. Diseases associated with TIMD4 include interdigitating dendritic cell sarcoma, and histiocytic sarcoma. An important paralog of this gene is HAVCR1.

UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15
Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating
T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIMD4 gene promoter:
         ISGF-3   AP-1   XBP-1   Nkx2-5   HNF-4alpha2   IRF-1   Evi-1   HNF-4alpha1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIMD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

TIMD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMD4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156278:  view genomic region     (about GC identifiers)

Start:
156,346,293 bp from pter      End:
156,390,266 bp from pter
Size:
43,974 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15 (See protein sequence)
Recommended Name: T-cell immunoglobulin and mucin domain-containing protein 4 precursor  
Size: 378 amino acids; 41578 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B5MCL9
Alternative splicing: 2 isoforms:  Q96H15-1   Q96H15-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TIMD4: NX_Q96H15

Explore proteomics data for TIMD4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96H15

  • TIMD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIMD4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001140198.1  NP_612388.2  

    ENSEMBL proteins: 
     ENSP00000274532   ENSP00000385882   ENSP00000385973  

    Human Recombinant Protein Products for TIMD4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TIMD4 (TIM-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TIMD4
    OriGene Protein Over-expression Lysate for TIMD4
    OriGene MassSpec for TIMD4 
    OriGene Custom Protein Services for TIMD4
    GenScript Custom Purified and Recombinant Proteins Services for TIMD4
    Novus Biologicals TIMD4 Proteins
    Sino Biological Recombinant Protein for TIMD4
    Sino Biological Cell Lysate for TIMD4 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIMD4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TIMD4 for ontologies           About GeneDecksing



    TIMD4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TIMD4 (TIM-4)
    OriGene Antibodies for TIMD4
    OriGene Custom Antibody Services for TIMD4
    GenScript Custom Superior Antibodies Services for TIMD4
    Novus Biologicals TIMD4 Antibodies
    Abcam antibodies for TIMD4
    Cloud-Clone Corp. Antibodies for TIMD4 
    ThermoFisher Antibodies for TIMD4
    LSBio Antibodies in human, mouse, rat for TIMD4 

    Assay Products for TIMD4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TIMD4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIMD4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIMD4 
    Cloud-Clone Corp. CLIAs for TIMD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q96H15

    ProtoNet protein and cluster: Q96H15

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15
    Domain: Recognizes phosphatidyl serine via its immunoglobulin domain
    Similarity: Belongs to the immunoglobulin superfamily. TIM family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    TIMD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIMD4_HUMAN, Q96H15
    Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating
    T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TIMD4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Timd4):
     cellular  hematopoietic system  immune system 

    TIMD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TIMD4: Timd4tm1Wouy Timd4tm1Kuch

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMD4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMD4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMD4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMD4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TIMD4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIMD4
    Sirion Biotech Customized adenovirus for overexpression of TIMD4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TIMD4 (see all 12)
    OriGene ORF clones in mouse, rat for TIMD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIMD4 (NM_138379)
    Sino Biological Human cDNA Clone for TIMD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMD4
    Sirion Biotech Customized lentivirus for stable overexpression of TIMD4 
                         Customized lentivirus expression plasmids for stable overexpression of TIMD4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIMD4
    Search LifeMap BioReagents cell lines for TIMD4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMD4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIMD4

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIMD4

    Search CenterWatch for drugs/clinical trials and news about TIMD4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIMD4 gene (2 alternative transcripts): 
    NM_001146726.1  NM_138379.2  

    Unigene Cluster for TIMD4:

    T-cell immunoglobulin and mucin domain containing 4
    Hs.334907  [show with all ESTs]
    Unigene Representative Sequence: BM559521
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274532(uc003lwh.2 uc010jii.2) ENST00000406964(uc003lwg.2)
    ENST00000407087
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIMD4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TIMD4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TIMD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMD4
    Clone
    Products:
         
    OriGene clones in human, mouse for TIMD4 (see all 12)
    OriGene ORF clones in mouse, rat for TIMD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIMD4 (NM_138379)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMD4
    Sirion Biotech Customized lentivirus for stable overexpression of TIMD4 
                         Customized lentivirus expression plasmids for stable overexpression of TIMD4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIMD4
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMD4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMD4

    Additional mRNA sequence: 

    AK131025.1 AK301337.1 AK312746.1 BC008988.1 JX049980.1 

    2 DOTS entries:

    DT.97783175  DT.92066900 

    24/29 AceView cDNA sequences (see all 29):

    BE552351 AA400536 AW516351 AI218853 NM_138379 BC008988 BP371340 CR603034 
    BX439191 BE550640 AA861640 AK131025 BF338867 BX281207 BQ182903 BX448841 
    AI862534 AW274868 AI149724 AI476417 AA936598 AW292593 AA843555 BU958106 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TIMD4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:                                -                       -               
    SP2:                                                        -               
    SP3:                                                                        


    ECgene alternative splicing isoforms for TIMD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIMD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTCCAGT
    TIMD4 Expression
    About this image


    See TIMD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIMD4

    SOURCE GeneReport for Unigene cluster: Hs.334907
        SABiosciences Custom PCR Arrays for TIMD4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TIMD4
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMD4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIMD4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMD4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TIMD4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timd41 , 5 T cell immunoglobulin and mucin domain containing 41, 5 68.63(n)1
    55.16(a)1
      11 (28.09 cM)5
    2768911  NM_178759.41  NP_848874.31 
     468108005 
    chicken
    (Gallus gallus)
    Aves TIMD41 T-cell immunoglobulin and mucin domain containing 4 48.45(n)
    37.79(a)
      416250  NM_001006149.1  NP_001006149.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIMD46
    T-cell immunoglobulin and mucin domain containing ...
    20(a)
    1 ↔ 1
    GL343205.1(2492000-2531449)
    zebrafish
    (Danio rerio)
    Actinopterygii havcr26
    havcr16
    (see all 3)
    hepatitis A virus cellular receptor 1
    (see all 3)
    23(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    21(28507148-28513954)
    21(28496783-28504565)


    ENSEMBL Gene Tree for TIMD4 (if available)
    TreeFam Gene Tree for TIMD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIMD4 gene
    HAVCR12  HAVCR22  

    TIMD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1072 SNPs in TIMD4 are shown (see all 1072)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs712850451,2
    C--151443431(-) GGGATTCTCA/
            
    TCTCT
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs1849045041,2
    --156345810(+) GTATCC/TCAGAA 2 -- int10--------
    rs1897891541,2
    --156345946(+) GGTAAC/TCATCT 2 -- int10--------
    rs112961651,2
    C--156345990(+) GAGAG-/AAAAAA 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs595867951,2
    C--156345991(+) AGAGAA/GAAAAA 2 -- int10--------
    rs1141887941,2
    C--156345992(+) GAGAAA/GAAAAA 2 -- int10--------
    rs113937721,2
    C--156346030(+) TTTTT-/TGTCCT 2 -- int10--------
    rs1808123351,2
    --156346064(+) TGATCC/TGGCAG 2 -- int10--------
    rs1461927321,2
    --156346134(+) TCATCC/TGGAGA 2 -- int10--------
    rs1393861441,2
    --156346202(+) CCTTGC/TGTGTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for TIMD4 (156346293 - 156390266 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TIMD4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674952CNV Deletion23128226
    esv2730953CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMD4
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610096    OMIM disorders: --

    20 diseases for TIMD4:    About MalaCards
    interdigitating dendritic cell sarcoma    histiocytic sarcoma    cerebral malaria    dendritic cell sarcoma
    hemophilia b    hepatitis a    hemophilia    allergic asthma
    malaria    atopic dermatitis    sarcoma    dermatitis
    asthma    cerebritis    systemic lupus erythematosus    hepatitis
    lupus erythematosus    hepatitis b    rheumatoid arthritis    arthritis


    TIMD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIMD4
    Human Genome Epidemiology (HuGE) Navigator: TIMD4 (8 documents)

    Export disorders for TIMD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIMD4 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with TIMD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PubMed id 18294362)1, 4, 9 Nuchnoi P....Patarapotikul J. (2008)
    2. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (2009)
    4. Association of TIM4 promoter polymorphism -1419G>A with childhood asthma in a Chinese Han population. (PubMed id 19392790)1, 4 Cai P.C....Wu Q.W. (2009)
    5. [Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China] (PubMed id 17407086)1, 4 Xia Y.P....Wu J.M. (2007)
    6. Genetic association studies between the T cell immunoglobulin mucin (TIM) gene locus and childhood atopic dermatitis. (PubMed id 16940744)1, 4 Page N.S....Stewart G.J. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    9. Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells fr om patients with system lupus erythematosus. (PubMed id 20140011)1, 9 Zhao P....Gao L. (2010)
    10. Genomic study in Mexicans identifies a new locus for t riglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91937 HGNC: 25132 AceView: TIMD4 Ensembl:ENSG00000145850 euGenes: HUgn91937
    ECgene: TIMD4 H-InvDB: TIMD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIMD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIMD4 gene:
    Search GeneIP for patents involving TIMD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TIMD4 (TIM-4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for TIMD4 (TIM-4)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TIMD4   OriGene RNAi products in human, mouse, rat for TIMD4  
     OriGene qPCR primer pairs and template standards for TIMD4   OriGene Protein Over-expression Lysate for TIMD4  
     OriGene MassSpec something-or-other for TIMD4   OriGene clones in human, mouse for TIMD4  
     OriGene qSTAR qPCR primer pairs in human, mouse for TIMD4   OriGene Purified Protein for TIMD4  
     OriGene ORF clones in mouse, rat for TIMD4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TIMD4   OriGene Custom Protein Services for TIMD4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIMD4
     QIAGEN SeqTarget long-range PCR primers for resequencing TIMD4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIMD4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIMD4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIMD4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIMD4
     GenScript Custom Purified and Recombinant Proteins Services for TIMD4 GenScript cDNA clones with any tag delivered in your preferred vector for TIMD4
     GenScript Custom Assay Services for TIMD4 GenScript Custom Superior Antibodies Services for TIMD4
     GenScript Custom overexpressing Cell Line Services for TIMD4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TIMD4 promoter
     Search Chromatin IP Primers for TIMD4
     RT2 qPCR Primer Assay in human, mouse, rat TIMD4
     Search GNC Networks for TIMD4
     SABiosciences Custom PCR Arrays for TIMD4
     Search Tocris compounds for TIMD4
     Proteins and Antibodies for TIMD4
     Cell Lysates for TIMD4
     cDNA Clones for TIMD4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TIMD4 antibodies
     TIMD4 proteins
     Antibodies for TIMD4
     See all of Abcam's Antibodies, Kits and Proteins for TIMD4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TIMD4
     Antibodies for TIMD4
     ELISAs for TIMD4
     CLIAs for TIMD4
     Search LifeMap BioReagents cell lines for TIMD4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMD4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TIMD4
     SwitchGear Promoter luciferase reporter plasmids for TIMD4
     ThermoFisher Antibodies for TIMD4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMD4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TIMD4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIMD4
    Customized:
     lentivirus for stable overexpression of TIMD4
     lentivirus expression plasmids for stable overexpression of TIMD4
     adenovirus for overexpression of TIMD4
     LSBio Antibodies in human, mouse, rat for TIMD4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TIMD4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4