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Aliases for TIMD4 Gene

Aliases for TIMD4 Gene

  • T-Cell Immunoglobulin And Mucin Domain Containing 4 2 3 5
  • T-Cell Immunoglobulin Mucin Receptor 4 3 4
  • T-Cell Membrane Protein 4 3 4
  • TIMD-4 3 4
  • TIM-4 3 4
  • TIM4 3 4

External Ids for TIMD4 Gene

Previous GeneCards Identifiers for TIMD4 Gene

  • GC05M156278
  • GC05M151439
  • GC05M156346

Summaries for TIMD4 Gene

GeneCards Summary for TIMD4 Gene

TIMD4 (T-Cell Immunoglobulin And Mucin Domain Containing 4) is a Protein Coding gene. Diseases associated with TIMD4 include Histiocytic Sarcoma and Malaria. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. An important paralog of this gene is HAVCR1.

UniProtKB/Swiss-Prot for TIMD4 Gene

  • Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMD4 Gene

Genomics for TIMD4 Gene

Regulatory Elements for TIMD4 Gene

Enhancers for TIMD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TIMD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIMD4 Gene

156,919,282 bp from pter
156,972,310 bp from pter
53,029 bases
Minus strand

Genomic View for TIMD4 Gene

Genes around TIMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMD4 Gene

Proteins for TIMD4 Gene

  • Protein details for TIMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell immunoglobulin and mucin domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B5MCL9

    Protein attributes for TIMD4 Gene

    378 amino acids
    Molecular mass:
    41578 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TIMD4 Gene

    Alternative splice isoforms for TIMD4 Gene


neXtProt entry for TIMD4 Gene

Proteomics data for TIMD4 Gene at MOPED

Post-translational modifications for TIMD4 Gene

  • Glycosylation at Asn 291
  • Modification sites at PhosphoSitePlus

Other Protein References for TIMD4 Gene

Antibody Products

  • Abcam antibodies for TIM 4

No data available for DME Specific Peptides for TIMD4 Gene

Domains & Families for TIMD4 Gene

Gene Families for TIMD4 Gene

Protein Domains for TIMD4 Gene

Suggested Antigen Peptide Sequences for TIMD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Recognizes phosphatidyl serine via its immunoglobulin domain.
  • Belongs to the immunoglobulin superfamily. TIM family.
  • Recognizes phosphatidyl serine via its immunoglobulin domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. TIM family.
genes like me logo Genes that share domains with TIMD4: view

Function for TIMD4 Gene

Molecular function for TIMD4 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

Gene Ontology (GO) - Molecular Function for TIMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TIMD4: view
genes like me logo Genes that share phenotypes with TIMD4: view

Animal Models for TIMD4 Gene

MGI Knock Outs for TIMD4:

Animal Model Products

miRNA for TIMD4 Gene

miRTarBase miRNAs that target TIMD4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMD4 Gene

Localization for TIMD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMD4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TIMD4 Gene COMPARTMENTS Subcellular localization image for TIMD4 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TIMD4 Gene

Pathways & Interactions for TIMD4 Gene

genes like me logo Genes that share pathways with TIMD4: view

Pathways by source for TIMD4 Gene

1 R&D Systems pathway for TIMD4 Gene

Interacting Proteins for TIMD4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000274532 for TIMD4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TIMD4 Gene


No data available for SIGNOR curated interactions for TIMD4 Gene

Drugs & Compounds for TIMD4 Gene

No Compound Related Data Available

Transcripts for TIMD4 Gene

Unigene Clusters for TIMD4 Gene

T-cell immunoglobulin and mucin domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: -

Relevant External Links for TIMD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMD4 Gene

mRNA expression in normal human tissues for TIMD4 Gene

mRNA differential expression in normal tissues according to GTEx for TIMD4 Gene

This gene is overexpressed in Testis (x31.0) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for TIMD4 Gene

This gene is overexpressed in Synovial fluid (45.7) and Peripheral blood mononuclear cells (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIMD4 Gene

SOURCE GeneReport for Unigene cluster for TIMD4 Gene Hs.334907

genes like me logo Genes that share expression patterns with TIMD4: view

Protein tissue co-expression partners for TIMD4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TIMD4 Gene

Orthologs for TIMD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIMD4 35
  • 72.01 (n)
  • 62.31 (a)
TIMD4 36
  • 53 (a)
(Canis familiaris)
Mammalia TIMD4 35
  • 72.33 (n)
  • 59.33 (a)
TIMD4 36
  • 54 (a)
(Mus musculus)
Mammalia Timd4 35
  • 67.94 (n)
  • 53.82 (a)
Timd4 16
Timd4 36
  • 48 (a)
(Pan troglodytes)
Mammalia TIMD4 35
  • 98.94 (n)
  • 97.35 (a)
TIMD4 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Timd4 35
  • 64.81 (n)
  • 50.56 (a)
(Monodelphis domestica)
Mammalia TIMD4 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
-- 36
  • 22 (a)
(Gallus gallus)
Aves TIMD4 35
  • 46.88 (n)
  • 35.73 (a)
TIMD4 36
  • 23 (a)
(Anolis carolinensis)
Reptilia TIMD4 36
  • 24 (a)
(Danio rerio)
Actinopterygii timd4 36
  • 13 (a)
Species with no ortholog for TIMD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMD4 Gene

Gene Tree for TIMD4 (if available)
Gene Tree for TIMD4 (if available)

Paralogs for TIMD4 Gene

Paralogs for TIMD4 Gene

genes like me logo Genes that share paralogs with TIMD4: view

Variants for TIMD4 Gene

Sequence variations from dbSNP and Humsavar for TIMD4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs6873053 - 156,949,692(+) ACTCA(A/G)CACTA reference, missense
rs7731575 - 156,919,501(+) CTGCA(A/C/T)GTCAT reference, missense
rs2862057 -- 156,928,140(+) tacaa(A/C)ataca intron-variant
rs2862058 -- 156,928,364(+) AAAAC(A/G)TCAGC intron-variant
rs2862059 -- 156,957,504(+) CGAGA(C/G)TCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMD4 Gene

Variant ID Type Subtype PubMed ID
esv2730953 CNV Deletion 23290073
esv2674952 CNV Deletion 23128226

Variation tolerance for TIMD4 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TIMD4 Gene

Disorders for TIMD4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TIMD4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
histiocytic sarcoma
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search TIMD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIMD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TIMD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIMD4 Gene

Publications for TIMD4 Gene

  1. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PMID: 18294362) Nuchnoi P. … Patarapotikul J. (Ann. Hum. Genet. 2008) 3 23 48 67
  2. Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus. (PMID: 20140011) Zhao P. … Gao L. (Cell. Mol. Immunol. 2010) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  5. TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner. (PMID: 26512878) Zhang Q. … Gao L. (Br. J. Cancer 2015) 3

Products for TIMD4 Gene

Sources for TIMD4 Gene