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TIMD4 Gene

protein-coding   GIFtS: 50
GCID: GC05M156346

T-Cell Immunoglobulin And Mucin Domain Containing 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Cell Immunoglobulin And Mucin Domain Containing 41 2     T-Cell Membrane Protein 42 3
TIM42 3 5     SMUCKLER2 5
TIM-42 3     T-Cell Immunoglobulin And Mucin Domain-Containing Protein 42
TIMD-42 3     TIMED45
T-Cell Immunoglobulin Mucin Receptor 42 3     

External Ids:    HGNC: 251321   Entrez Gene: 919372   Ensembl: ENSG000001458507   OMIM: 6100965   UniProtKB: Q96H153   

Export aliases for TIMD4 gene to outside databases

Previous GC identifers: GC05M156278 GC05M151439


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TIMD4 Gene:
TIMD4 (T-cell immunoglobulin and mucin domain containing 4) is a protein-coding gene. Diseases associated with TIMD4 include interdigitating dendritic cell sarcoma, and histiocytic sarcoma. An important paralog of this gene is HAVCR1.

UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15
Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating
T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIMD4 gene promoter:
         ISGF-3   AP-1   XBP-1   Nkx2-5   HNF-4alpha2   IRF-1   Evi-1   HNF-4alpha1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIMD4 promoter sequence
   Search Chromatin IP Primers for TIMD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIMD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

TIMD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMD4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M156346:  view genomic region     (about GC identifiers)

Start:
156,346,293 bp from pter      End:
156,390,266 bp from pter
Size:
43,974 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15 (See protein sequence)
Recommended Name: T-cell immunoglobulin and mucin domain-containing protein 4 precursor  
Size: 378 amino acids; 41578 Da
Secondary accessions: B5MCL9
Alternative splicing: 2 isoforms:  Q96H15-1   Q96H15-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TIMD4: NX_Q96H15

Explore proteomics data for TIMD4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn291
  • Modification sites at PhosphoSitePlus

  • See TIMD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001140198.1  NP_612388.2  

    ENSEMBL proteins: 
     ENSP00000274532   ENSP00000385882   ENSP00000385973  

    TIMD4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TIMD4 (TIM-4)
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    OriGene Protein Over-expression Lysate for TIMD4
    OriGene MassSpec for TIMD4
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    GenScript Custom Purified and Recombinant Proteins Services for TIMD4
    Novus Biologicals TIMD4 Proteins
    Sino Biological Recombinant Protein for TIMD4
    Sino Biological Cell Lysate for TIMD4
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIMD4

    TIMD4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TIMD4 (TIM-4)
    OriGene Antibodies for TIMD4
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    Novus Biologicals TIMD4 Antibodies
    Abcam antibodies for TIMD4
    Cloud-Clone Corp. Antibodies for TIMD4
    ThermoFisher Antibodies for TIMD4
    LSBio Antibodies in human, mouse, rat for TIMD4

    TIMD4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TIMD4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIMD4
    Cloud-Clone Corp. CLIAs for TIMD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q96H15

    ProtoNet protein and cluster: Q96H15

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15
    Domain: Recognizes phosphatidyl serine via its immunoglobulin domain
    Similarity: Belongs to the immunoglobulin superfamily. TIM family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    TIMD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIMD4_HUMAN, Q96H15
    Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating
    T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TIMD4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Timd4):
     cellular  hematopoietic system  immune system 

    TIMD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TIMD4: Timd4tm1Wouy Timd4tm1Kuch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIMD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIMD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIMD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIMD4

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TIMD4
    Predesigned siRNA for gene silencing in human, mouse, rat TIMD4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TIMD4

    Clone
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    OriGene clones in human, mouse for TIMD4 (see all 12)
    OriGene ORF clones in mouse, rat for TIMD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIMD4 (NM_138379)
    Sino Biological Human cDNA Clone for TIMD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMD4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TIMD4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIMD4_HUMAN, Q96H15: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TIMD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIMD4
    Interactions:

        Search GeneGlobe Interaction Network for TIMD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TIMD4 (ENSP000002745324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAVCR1ENSP000003448444STRING: ENSP00000344844
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIMD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TIMD4 gene (2 alternative transcripts): 
    NM_001146726.1  NM_138379.2  

    Unigene Cluster for TIMD4:

    T-cell immunoglobulin and mucin domain containing 4
    Hs.334907  [show with all ESTs]
    Unigene Representative Sequence: BM559521
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274532(uc003lwh.2 uc010jii.2) ENST00000406964(uc003lwg.2)
    ENST00000407087
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TIMD4
    Predesigned siRNA for gene silencing in human, mouse, rat TIMD4
    Clone
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    OriGene clones in human, mouse for TIMD4 (see all 12)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIMD4 (NM_138379)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIMD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIMD4
    Primer
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    OriGene qPCR primer pairs and template standards for TIMD4
    OriGene qSTAR qPCR primer pairs in human, mouse for TIMD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIMD4
      QuantiTect SYBR Green Assays in human, mouse, rat TIMD4
      QuantiFast Probe-based Assays in human, mouse, rat TIMD4

    Additional mRNA sequence: 

    AK131025.1 AK301337.1 AK312746.1 BC008988.1 JX049980.1 

    2 DOTS entries:

    DT.97783175  DT.92066900 

    Selected AceView cDNA sequences (see all 29):

    BE550640 NM_138379 AI218853 BE552351 AK131025 AA861640 BX439191 AW516351 
    CR603034 AA400536 BP371340 BC008988 BF338867 BX448841 AI476417 AW274868 
    AI862534 BQ182903 BX281207 AI149724 AW292593 AA843555 AA936598 AA759080 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TIMD4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:                                -                       -               
    SP2:                                                        -               
    SP3:                                                                        


    ECgene alternative splicing isoforms for TIMD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIMD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTCCAGT
    TIMD4 Expression
    About this image

    TIMD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIMD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334907
        Custom PCR Arrays for TIMD4
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    OriGene qPCR primer pairs and template standards for TIMD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIMD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TIMD4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Timd41 , 5 T cell immunoglobulin and mucin domain containing 41, 5 67.94(n)1
    53.82(a)1
      11 (28.09 cM)5
    2768911  NM_178759.41  NP_848874.31 
     468108005 
    chicken
    (Gallus gallus)
    Aves TIMD41 T-cell immunoglobulin and mucin domain containing 4 46.88(n)
    35.73(a)
      416250  NM_001006149.1  NP_001006149.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIMD46
    T-cell immunoglobulin and mucin domain containing ...
    24(a)
    1 ↔ 1
    GL343205.1(2492000-2531449)
    zebrafish
    (Danio rerio)
    Actinopterygii timd46
    T-cell immunoglobulin and mucin domain containing ...
    13(a)
    1 → many
    21(28485046-28494504) ENSDARG00000077257


    ENSEMBL Gene Tree for TIMD4 (if available)
    TreeFam Gene Tree for TIMD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIMD4 gene
    HAVCR12  HAVCR22  

    TIMD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIMD4 (see all 1072)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs712850451,2
    C--151443431(-) GGGATTCTCA/
            
    TCTCT
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs1849045041,2
    --156345810(+) GTATCC/TCAGAA 2 -- int10--------
    rs1897891541,2
    --156345946(+) GGTAAC/TCATCT 2 -- int10--------
    rs112961651,2
    C--156345990(+) GAGAG-/AAAAAA 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs595867951,2
    C--156345991(+) AGAGAA/GAAAAA 2 -- int10--------
    rs1141887941,2
    C--156345992(+) GAGAAA/GAAAAA 2 -- int10--------
    rs113937721,2
    C--156346030(+) TTTTT-/TGTCCT 2 -- int10--------
    rs1808123351,2
    --156346064(+) TGATCC/TGGCAG 2 -- int10--------
    rs1461927321,2
    --156346134(+) TCATCC/TGGAGA 2 -- int10--------
    rs1393861441,2
    --156346202(+) CCTTGC/TGTGTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for TIMD4 (156346293 - 156390266 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TIMD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674952CNV Deletion23128226
    esv2730953CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIMD4
    DNA2.0 Custom Variant and Variant Library Synthesis for TIMD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610096    OMIM disorders: --

    20 diseases for TIMD4:    About MalaCards
    interdigitating dendritic cell sarcoma    histiocytic sarcoma    dendritic cell sarcoma    hepatitis a
    hemophilia b    hemophilia    cerebral malaria    allergic asthma
    malaria    sarcoma    atopic dermatitis    asthma
    dermatitis    cerebritis    systemic lupus erythematosus    hepatitis
    lupus erythematosus    hepatitis b    rheumatoid arthritis    arthritis


    TIMD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIMD4
    Human Genome Epidemiology (HuGE) Navigator: TIMD4 (8 documents)

    Export disorders for TIMD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIMD4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with TIMD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PubMed id 18294362)1, 4, 9 Nuchnoi P....Patarapotikul J. (Ann. Hum. Genet. 2008)
    2. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    4. Association of TIM4 promoter polymorphism -1419G&gt;A with childhood asthma in a Chinese Han population. (PubMed id 19392790)1, 4 Cai P.C....Wu Q.W. (Tissue Antigens 2009)
    5. [Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China]. (PubMed id 17407086)1, 4 Xia Y.P....Wu J.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    6. Genetic association studies between the T cell immunoglobulin mucin (TIM) gene locus and childhood atopic dermatitis. (PubMed id 16940744)1, 4 Page N.S....Stewart G.J. (Int. Arch. Allergy Immunol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus. (PubMed id 20140011)1, 9 Zhao P....Gao L. (amp 2010)
    10. Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine. (PubMed id 24286866)1 Schweigert O....Scheller J. (Biochim. Biophys. Acta 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91937 HGNC: 25132 AceView: TIMD4 Ensembl:ENSG00000145850 euGenes: HUgn91937
    ECgene: TIMD4 H-InvDB: TIMD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TIMD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TIMD4 gene:
    Search GeneIP for patents involving TIMD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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