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Aliases for TIMD4 Gene

Aliases for TIMD4 Gene

  • T-Cell Immunoglobulin And Mucin Domain Containing 4 2 3
  • TIM4 3 4 6
  • T-Cell Immunoglobulin Mucin Receptor 4 3 4
  • T-Cell Membrane Protein 4 3 4
  • SMUCKLER 3 6
  • TIMD-4 3 4
  • TIM-4 3 4
  • T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4 3
  • TIMED4 6

External Ids for TIMD4 Gene

Previous GeneCards Identifiers for TIMD4 Gene

  • GC05M156278
  • GC05M151439
  • GC05M156346

Summaries for TIMD4 Gene

GeneCards Summary for TIMD4 Gene

TIMD4 (T-Cell Immunoglobulin And Mucin Domain Containing 4) is a Protein Coding gene. Diseases associated with TIMD4 include histiocytic sarcoma and malaria. An important paralog of this gene is HAVCR2.

UniProtKB/Swiss-Prot for TIMD4 Gene

  • Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMD4 Gene

Genomics for TIMD4 Gene

Regulatory Elements for TIMD4 Gene

Genomic Location for TIMD4 Gene

156,919,282 bp from pter
156,963,255 bp from pter
43,974 bases
Minus strand

Genomic View for TIMD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMD4 Gene

Proteins for TIMD4 Gene

  • Protein details for TIMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell immunoglobulin and mucin domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B5MCL9

    Protein attributes for TIMD4 Gene

    378 amino acids
    Molecular mass:
    41578 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TIMD4 Gene


neXtProt entry for TIMD4 Gene

Proteomics data for TIMD4 Gene at MOPED

Post-translational modifications for TIMD4 Gene

  • Glycosylation at Asn291
  • Modification sites at PhosphoSitePlus

Other Protein References for TIMD4 Gene

No data available for DME Specific Peptides for TIMD4 Gene

Domains for TIMD4 Gene

Gene Families for TIMD4 Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for TIMD4 Gene

Suggested Antigen Peptide Sequences for TIMD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96H15
  • Recognizes phosphatidyl serine via its immunoglobulin domain
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. TIM family.
genes like me logo Genes that share domains with TIMD4: view

Function for TIMD4 Gene

Molecular function for TIMD4 Gene

UniProtKB/Swiss-Prot Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

Gene Ontology (GO) - Molecular Function for TIMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TIMD4: view

Phenotypes for TIMD4 Gene

genes like me logo Genes that share phenotypes with TIMD4: view

Animal Models for TIMD4 Gene

MGI Knock Outs for TIMD4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TIMD4 Gene

Localization for TIMD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMD4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TIMD4 Gene COMPARTMENTS Subcellular localization image for TIMD4 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TIMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIMD4: view

Pathways for TIMD4 Gene

SuperPathways for TIMD4 Gene

No Data Available

Interacting Proteins for TIMD4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000274532 for TIMD4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TIMD4 Gene


No data available for Pathways by source for TIMD4 Gene

Transcripts for TIMD4 Gene

Unigene Clusters for TIMD4 Gene

T-cell immunoglobulin and mucin domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIMD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: -

Relevant External Links for TIMD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMD4 Gene

mRNA expression in normal human tissues for TIMD4 Gene

mRNA differential expression in normal tissues according to GTEx for TIMD4 Gene

This gene is overexpressed in Testis (31.0) and Spleen (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIMD4 Gene

SOURCE GeneReport for Unigene cluster for TIMD4 Gene Hs.334907

genes like me logo Genes that share expressions with TIMD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TIMD4 Gene

Orthologs for TIMD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIMD4 35
  • 98.94 (n)
  • 97.35 (a)
TIMD4 36
  • 97 (a)
(Bos Taurus)
Mammalia TIMD4 35
  • 72.01 (n)
  • 62.31 (a)
TIMD4 36
  • 53 (a)
(Canis familiaris)
Mammalia TIMD4 35
  • 72.33 (n)
  • 59.33 (a)
TIMD4 36
  • 54 (a)
(Mus musculus)
Mammalia Timd4 35
  • 67.94 (n)
  • 53.82 (a)
Timd4 16
Timd4 36
  • 48 (a)
(Monodelphis domestica)
Mammalia TIMD4 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
-- 36
  • 22 (a)
(Rattus norvegicus)
Mammalia Timd4 35
  • 64.81 (n)
  • 50.56 (a)
(Gallus gallus)
Aves TIMD4 35
  • 46.88 (n)
  • 35.73 (a)
TIMD4 36
  • 23 (a)
(Anolis carolinensis)
Reptilia TIMD4 36
  • 24 (a)
(Danio rerio)
Actinopterygii timd4 36
  • 13 (a)
Species with no ortholog for TIMD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMD4 Gene

Gene Tree for TIMD4 (if available)
Gene Tree for TIMD4 (if available)

Paralogs for TIMD4 Gene

Paralogs for TIMD4 Gene

genes like me logo Genes that share paralogs with TIMD4: view

Variants for TIMD4 Gene

Sequence variations from dbSNP and Humsavar for TIMD4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1345616 -- 156,924,663(-) GTTCT(C/T)CTTCC intron-variant
rs1345617 -- 156,924,492(-) CAAAA(C/G)AAGTC intron-variant
rs1345618 -- 156,924,336(-) TTTAT(A/G)TAGCT intron-variant
rs1363232 -- 156,956,411(-) ACTCA(C/T)GCTTC intron-variant
rs1975026 -- 156,943,818(-) TGCCT(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIMD4 Gene

Variant ID Type Subtype PubMed ID
esv2730953 CNV Deletion 23290073
esv2674952 CNV Deletion 23128226

Relevant External Links for TIMD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMD4 Gene

Disorders for TIMD4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TIMD4 Gene including...

Search for TIMD4 Gene in MalaCards »

Relevant External Links for TIMD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TIMD4: view

No data available for UniProtKB/Swiss-Prot for TIMD4 Gene

Publications for TIMD4 Gene

  1. Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PMID: 18294362) Nuchnoi P. … Patarapotikul J. (Ann. Hum. Genet. 2008) 3 23 48
  2. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 48
  3. Association of TIM4 promoter polymorphism -1419G>A with childhood asthma in a Chinese Han population. (PMID: 19392790) Cai P.C. … Wu Q.W. (Tissue Antigens 2009) 3 48
  4. Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus. (PMID: 20140011) Zhao P. … Gao L. (Cell. Mol. Immunol. 2010) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for TIMD4 Gene

Sources for TIMD4 Gene

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