Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIGIT Gene

Aliases for TIGIT Gene

  • T-Cell Immunoreceptor With Ig And ITIM Domains 2 3 5
  • V-Set And Immunoglobulin Domain-Containing Protein 9 3 4
  • V-Set And Transmembrane Domain-Containing Protein 3 3 4
  • V-Set And Immunoglobulin Domain Containing 9 2 3
  • V-Set And Transmembrane Domain Containing 3 2 3
  • VSIG9 3 4
  • VSTM3 3 4
  • T Cell Immunoreceptor With Ig And ITIM Domains 2
  • Washington University Cell Adhesion Molecule 3
  • WUCAM 3

External Ids for TIGIT Gene

Previous HGNC Symbols for TIGIT Gene

  • VSIG9
  • VSTM3

Previous GeneCards Identifiers for TIGIT Gene

  • GC03P115496
  • GC03P113995
  • GC03P111385

Summaries for TIGIT Gene

Entrez Gene Summary for TIGIT Gene

  • This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

GeneCards Summary for TIGIT Gene

TIGIT (T-Cell Immunoreceptor With Ig And ITIM Domains) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for TIGIT Gene

  • Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGIT Gene

Genomics for TIGIT Gene

Regulatory Elements for TIGIT Gene

Enhancers for TIGIT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TIGIT on UCSC Golden Path with GeneCards custom track

Genomic Location for TIGIT Gene

Chromosome:
3
Start:
114,276,913 bp from pter
End:
114,310,288 bp from pter
Size:
33,376 bases
Orientation:
Plus strand

Genomic View for TIGIT Gene

Genes around TIGIT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGIT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGIT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGIT Gene

Proteins for TIGIT Gene

  • Protein details for TIGIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495A1-TIGIT_HUMAN
    Recommended name:
    T-cell immunoreceptor with Ig and ITIM domains
    Protein Accession:
    Q495A1
    Secondary Accessions:
    • Q495A3
    • Q5JPD8
    • Q6MZS2
    • Q8N877

    Protein attributes for TIGIT Gene

    Size:
    244 amino acids
    Molecular mass:
    26319 Da
    Quaternary structure:
    • Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to NECTIN2 and NECTIN3.
    SequenceCaution:
    • Sequence=CAI46183.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TIGIT Gene

    Alternative splice isoforms for TIGIT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIGIT Gene

Post-translational modifications for TIGIT Gene

  • Glycosylation at Asn 32 and Asn 101
  • Modification sites at PhosphoSitePlus

Other Protein References for TIGIT Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for TIGIT

No data available for DME Specific Peptides for TIGIT Gene

Domains & Families for TIGIT Gene

Gene Families for TIGIT Gene

Protein Domains for TIGIT Gene

Suggested Antigen Peptide Sequences for TIGIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495A1

UniProtKB/Swiss-Prot:

TIGIT_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TIGIT: view

Function for TIGIT Gene

Molecular function for TIGIT Gene

UniProtKB/Swiss-Prot Function:
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Gene Ontology (GO) - Molecular Function for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IPI 19011627
GO:0005515 protein binding IPI 19011627
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with TIGIT: view

Phenotypes for TIGIT Gene

MGI mutant phenotypes for TIGIT:
inferred from 1 alleles
GenomeRNAi human phenotypes for TIGIT:
genes like me logo Genes that share phenotypes with TIGIT: view

Animal Models for TIGIT Gene

MGI Knock Outs for TIGIT:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIGIT Gene

Localization for TIGIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGIT Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIGIT Gene COMPARTMENTS Subcellular localization image for TIGIT gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0005913 cell-cell adherens junction IBA --
GO:0009986 cell surface IDA 19011627
genes like me logo Genes that share ontologies with TIGIT: view

Pathways & Interactions for TIGIT Gene

genes like me logo Genes that share pathways with TIGIT: view

Interacting Proteins for TIGIT Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373167%0d%0a9606.ENSP00000402060%0d%0a9606.ENSP00000418070%0d%0a9606.ENSP00000252483%0d%0a9606.ENSP00000356991%0d%0a
Selected Interacting proteins: ENSP00000373167 Q495A1-TIGIT_HUMAN for TIGIT Gene via STRING UniProtKB IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-DRB1
NECTIN3
NECTIN4

Gene Ontology (GO) - Biological Process for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
GO:0032695 negative regulation of interleukin-12 production IMP 19011627
GO:0032733 positive regulation of interleukin-10 production IMP 19011627
genes like me logo Genes that share ontologies with TIGIT: view

No data available for SIGNOR curated interactions for TIGIT Gene

Drugs & Compounds for TIGIT Gene

No Compound Related Data Available

Transcripts for TIGIT Gene

mRNA/cDNA for TIGIT Gene

Unigene Clusters for TIGIT Gene

T cell immunoreceptor with Ig and ITIM domains:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGIT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TIGIT Gene

GeneLoc Exon Structure for
TIGIT
ECgene alternative splicing isoforms for
TIGIT

Expression for TIGIT Gene

mRNA expression in normal human tissues for TIGIT Gene

mRNA differential expression in normal tissues according to GTEx for TIGIT Gene

This gene is overexpressed in Whole Blood (x15.3), Spleen (x8.7), and Small Intestine - Terminal Ileum (x5.4).

Protein differential expression in normal tissues from HIPED for TIGIT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGIT Gene



Protein tissue co-expression partners for TIGIT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIGIT Gene:

TIGIT

SOURCE GeneReport for Unigene cluster for TIGIT Gene:

Hs.421750

mRNA Expression by UniProt/SwissProt for TIGIT Gene:

Q495A1-TIGIT_HUMAN
Tissue specificity: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).
genes like me logo Genes that share expression patterns with TIGIT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TIGIT Gene

Orthologs for TIGIT Gene

This gene was present in the common ancestor of mammals.

Orthologs for TIGIT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIGIT 34
  • 77.64 (n)
  • 67.08 (a)
TIGIT 35
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIGIT 34
  • 77.05 (n)
  • 66.39 (a)
TIGIT 35
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tigit 34
  • 75.31 (n)
  • 61.51 (a)
Tigit 16
Tigit 35
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIGIT 34
  • 98.5 (n)
  • 98.36 (a)
TIGIT 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tigit 34
  • 73.81 (n)
  • 59.66 (a)
oppossum
(Monodelphis domestica)
Mammalia TIGIT 35
  • 37 (a)
OneToOne
Species where no ortholog for TIGIT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGIT Gene

ENSEMBL:
Gene Tree for TIGIT (if available)
TreeFam:
Gene Tree for TIGIT (if available)

Paralogs for TIGIT Gene

No data available for Paralogs for TIGIT Gene

Variants for TIGIT Gene

Sequence variations from dbSNP and Humsavar for TIGIT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13098836 - 114,295,580(+) GGAAC(A/G)TTTCT reference, missense
rs1405088 -- 114,301,301(-) CAGAA(C/T)TGAGT intron-variant
rs1039523 -- 114,299,206(-) AATTC(A/G)AAATT intron-variant
rs1039524 -- 114,293,427(-) ACTTT(A/G)TTGAA upstream-variant-2KB
rs4682159 -- 114,309,302(+) TGAAC(C/T)GCTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIGIT Gene

Variant ID Type Subtype PubMed ID
dgv2580n106 CNV deletion 24896259
dgv921e214 CNV gain 21293372
esv1507464 CNV deletion 17803354
esv2043603 CNV deletion 18987734
esv2725786 CNV deletion 23290073
esv2742710 CNV deletion 23290073
esv3562406 CNV deletion 23714750
esv3597455 CNV loss 21293372
nsv1149670 CNV deletion 26484159
nsv441835 CNV loss 18776908
nsv822223 CNV loss 20364138

Variation tolerance for TIGIT Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGIT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIGIT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGIT Gene

Disorders for TIGIT Gene

Relevant External Links for TIGIT

Genetic Association Database (GAD)
TIGIT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIGIT

No disorders were found for TIGIT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGIT Gene

Publications for TIGIT Gene

  1. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. (PMID: 19011627) Yu X. … Grogan J.L. (Nat. Immunol. 2009) 2 3 4 65
  2. Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. (PMID: 22421438) Stengel K.F. … Grogan J.L. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). (PMID: 26735971) Yasuma K. … Matsuoka M. (PLoS Pathog. 2016) 3 65
  5. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. (PMID: 26741490) Chew G.M. … Ndhlovu L.C. (PLoS Pathog. 2016) 3 65

Products for TIGIT Gene

Sources for TIGIT Gene

Content