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Aliases for TIGIT Gene

Aliases for TIGIT Gene

  • T Cell Immunoreceptor With Ig And ITIM Domains 2 3
  • V-Set And Immunoglobulin Domain-Containing Protein 9 3 4
  • V-Set And Transmembrane Domain-Containing Protein 3 3 4
  • V-Set And Immunoglobulin Domain Containing 9 2 3
  • V-Set And Transmembrane Domain Containing 3 2 3
  • VSIG9 3 4
  • VSTM3 3 4
  • T-Cell Immunoreceptor With Ig And ITIM Domains 3
  • Washington University Cell Adhesion Molecule 3
  • WUCAM 3

External Ids for TIGIT Gene

Previous HGNC Symbols for TIGIT Gene

  • VSIG9
  • VSTM3

Previous GeneCards Identifiers for TIGIT Gene

  • GC03P115496
  • GC03P113995
  • GC03P111385

Summaries for TIGIT Gene

Entrez Gene Summary for TIGIT Gene

  • This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

GeneCards Summary for TIGIT Gene

TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for TIGIT Gene

  • Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGIT Gene

Genomics for TIGIT Gene

Genomic Location for TIGIT Gene

Start:
114,276,913 bp from pter
End:
114,312,158 bp from pter
Size:
35,246 bases
Orientation:
Plus strand

Genomic View for TIGIT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIGIT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGIT Gene

Proteins for TIGIT Gene

  • Protein details for TIGIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495A1-TIGIT_HUMAN
    Recommended name:
    T-cell immunoreceptor with Ig and ITIM domains
    Protein Accession:
    Q495A1
    Secondary Accessions:
    • Q495A3
    • Q5JPD8
    • Q6MZS2
    • Q8N877

    Protein attributes for TIGIT Gene

    Size:
    244 amino acids
    Molecular mass:
    26319 Da
    Quaternary structure:
    • Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to PVRL2 and PVRL3.
    SequenceCaution:
    • Sequence=CAI46183.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TIGIT Gene

    Alternative splice isoforms for TIGIT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIGIT Gene

Proteomics data for TIGIT Gene at MOPED

Post-translational modifications for TIGIT Gene

  • Glycosylation at Asn32 and Asn101
  • Modification sites at PhosphoSitePlus

Other Protein References for TIGIT Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TIGIT

No data available for DME Specific Peptides for TIGIT Gene

Domains for TIGIT Gene

Gene Families for TIGIT Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for TIGIT Gene

Suggested Antigen Peptide Sequences for TIGIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495A1

UniProtKB/Swiss-Prot:

TIGIT_HUMAN :
  • Q495A1
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TIGIT: view

Function for TIGIT Gene

Molecular function for TIGIT Gene

UniProtKB/Swiss-Prot Function:
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Gene Ontology (GO) - Molecular Function for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 19011627
GO:0005515 protein binding IPI 19011627
genes like me logo Genes that share ontologies with TIGIT: view

Phenotypes for TIGIT Gene

genes like me logo Genes that share phenotypes with TIGIT: view

Animal Models for TIGIT Gene

MGI Knock Outs for TIGIT:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TIGIT Gene

Localization for TIGIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGIT Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIGIT Gene COMPARTMENTS Subcellular localization image for TIGIT gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 19011627
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIGIT: view

Pathways for TIGIT Gene

SuperPathways for TIGIT Gene

genes like me logo Genes that share pathways with TIGIT: view

Pathways by source for TIGIT Gene

1 KEGG pathway for TIGIT Gene

Gene Ontology (GO) - Biological Process for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032695 negative regulation of interleukin-12 production IMP 19011627
GO:0032733 positive regulation of interleukin-10 production IMP 19011627
GO:0050868 negative regulation of T cell activation IMP 19011627
genes like me logo Genes that share ontologies with TIGIT: view

Transcripts for TIGIT Gene

mRNA/cDNA for TIGIT Gene

Unigene Clusters for TIGIT Gene

T cell immunoreceptor with Ig and ITIM domains:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGIT

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGIT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TIGIT Gene

GeneLoc Exon Structure for
TIGIT
ECgene alternative splicing isoforms for
TIGIT

Expression for TIGIT Gene

mRNA expression in normal human tissues for TIGIT Gene

mRNA differential expression in normal tissues according to GTEx for TIGIT Gene

This gene is overexpressed in Whole Blood (15.3), Spleen (8.7), and Small Intestine - Terminal Ileum (5.4).

Protein differential expression in normal tissues for TIGIT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIGIT Gene

SOURCE GeneReport for Unigene cluster for TIGIT Gene Hs.421750

mRNA Expression by UniProt/SwissProt for TIGIT Gene

Q495A1-TIGIT_HUMAN
Tissue specificity: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).
genes like me logo Genes that share expressions with TIGIT: view

Expression partners for TIGIT Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TIGIT Gene

Orthologs for TIGIT Gene

This gene was present in the common ancestor of mammals.

Orthologs for TIGIT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIGIT 35
  • 77.64 (n)
  • 67.08 (a)
TIGIT 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIGIT 35
  • 77.05 (n)
  • 66.39 (a)
TIGIT 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tigit 35
  • 75.31 (n)
  • 61.51 (a)
Tigit 16
Tigit 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIGIT 35
  • 98.5 (n)
  • 98.36 (a)
TIGIT 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tigit 35
  • 73.81 (n)
  • 59.66 (a)
oppossum
(Monodelphis domestica)
Mammalia TIGIT 36
  • 37 (a)
OneToOne
Species with no ortholog for TIGIT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGIT Gene

ENSEMBL:
Gene Tree for TIGIT (if available)
TreeFam:
Gene Tree for TIGIT (if available)

Paralogs for TIGIT Gene

No data available for Paralogs for TIGIT Gene

Variants for TIGIT Gene

Sequence variations from dbSNP and Humsavar for TIGIT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1039523 -- 114,299,206(-) AATTC(A/G)AAATT intron-variant
rs1039524 -- 114,293,427(-) ACTTT(A/G)TTGAA upstream-variant-2KB
rs1316642 -- 114,305,216(+) TCAGT(A/G)CACCA intron-variant
rs1405088 -- 114,301,301(-) CAGAA(C/T)TGAGT intron-variant
rs2654758 -- 114,297,200(-) TAACC(A/G)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIGIT Gene

Variant ID Type Subtype PubMed ID
esv2043603 CNV Deletion 18987734
esv2725786 CNV Deletion 23290073
esv1507464 CNV Deletion 17803354
esv2742710 CNV Deletion 23290073
nsv822223 CNV Loss 20364138
nsv441835 CNV CNV 18776908

Relevant External Links for TIGIT Gene

HapMap Linkage Disequilibrium report
TIGIT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGIT Gene

Disorders for TIGIT Gene

Relevant External Links for TIGIT

Genetic Association Database (GAD)
TIGIT

No disorders were found for TIGIT Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TIGIT Gene

Publications for TIGIT Gene

  1. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. (PMID: 19011627) Yu X. … Grogan J.L. (Nat. Immunol. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. (PMID: 22421438) Stengel K.F. … Grogan J.L. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  4. The TIGIT/CD226 axis regulates human T cell function. (PMID: 22427644) Lozano E. … Hafler D.A. (J. Immunol. 2012) 3
  5. Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection. (PMID: 22706088) Moorman J.P. … Yao Z.Q. (J. Immunol. 2012) 3

Products for TIGIT Gene

Sources for TIGIT Gene

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