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Aliases for TIGIT Gene

Aliases for TIGIT Gene

  • T-Cell Immunoreceptor With Ig And ITIM Domains 2 3 5
  • V-Set And Immunoglobulin Domain-Containing Protein 9 3 4
  • V-Set And Transmembrane Domain-Containing Protein 3 3 4
  • T Cell Immunoreceptor With Ig And ITIM Domains 2 3
  • V-Set And Immunoglobulin Domain Containing 9 2 3
  • V-Set And Transmembrane Domain Containing 3 2 3
  • VSIG9 3 4
  • VSTM3 3 4
  • Washington University Cell Adhesion Molecule 3
  • WUCAM 3

External Ids for TIGIT Gene

Previous HGNC Symbols for TIGIT Gene

  • VSIG9
  • VSTM3

Previous GeneCards Identifiers for TIGIT Gene

  • GC03P115496
  • GC03P113995
  • GC03P111385

Summaries for TIGIT Gene

Entrez Gene Summary for TIGIT Gene

  • This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

GeneCards Summary for TIGIT Gene

TIGIT (T-Cell Immunoreceptor With Ig And ITIM Domains) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs) and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for TIGIT Gene

  • Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGIT Gene

Genomics for TIGIT Gene

Regulatory Elements for TIGIT Gene

Enhancers for TIGIT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TIGIT on UCSC Golden Path with GeneCards custom track

Genomic Location for TIGIT Gene

Chromosome:
3
Start:
114,276,913 bp from pter
End:
114,310,288 bp from pter
Size:
33,376 bases
Orientation:
Plus strand

Genomic View for TIGIT Gene

Genes around TIGIT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGIT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGIT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGIT Gene

Proteins for TIGIT Gene

  • Protein details for TIGIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495A1-TIGIT_HUMAN
    Recommended name:
    T-cell immunoreceptor with Ig and ITIM domains
    Protein Accession:
    Q495A1
    Secondary Accessions:
    • Q495A3
    • Q5JPD8
    • Q6MZS2
    • Q8N877

    Protein attributes for TIGIT Gene

    Size:
    244 amino acids
    Molecular mass:
    26319 Da
    Quaternary structure:
    • Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to PVRL2 and PVRL3.
    SequenceCaution:
    • Sequence=CAI46183.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TIGIT Gene

    Alternative splice isoforms for TIGIT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIGIT Gene

Proteomics data for TIGIT Gene at MOPED

Post-translational modifications for TIGIT Gene

  • Glycosylation at Asn 32 and Asn 101
  • Modification sites at PhosphoSitePlus

Other Protein References for TIGIT Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TIGIT

No data available for DME Specific Peptides for TIGIT Gene

Domains & Families for TIGIT Gene

Gene Families for TIGIT Gene

Protein Domains for TIGIT Gene

Suggested Antigen Peptide Sequences for TIGIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495A1

UniProtKB/Swiss-Prot:

TIGIT_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TIGIT: view

Function for TIGIT Gene

Molecular function for TIGIT Gene

UniProtKB/Swiss-Prot Function:
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Gene Ontology (GO) - Molecular Function for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with TIGIT: view

Phenotypes for TIGIT Gene

MGI mutant phenotypes for TIGIT:
inferred from 1 alleles
GenomeRNAi human phenotypes for TIGIT:
genes like me logo Genes that share phenotypes with TIGIT: view

Animal Models for TIGIT Gene

MGI Knock Outs for TIGIT:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIGIT Gene

Localization for TIGIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGIT Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIGIT Gene COMPARTMENTS Subcellular localization image for TIGIT gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIGIT: view

Pathways & Interactions for TIGIT Gene

genes like me logo Genes that share pathways with TIGIT: view

Gene Ontology (GO) - Biological Process for TIGIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
genes like me logo Genes that share ontologies with TIGIT: view

No data available for SIGNOR curated interactions for TIGIT Gene

Drugs & Compounds for TIGIT Gene

No Compound Related Data Available

Transcripts for TIGIT Gene

Unigene Clusters for TIGIT Gene

T cell immunoreceptor with Ig and ITIM domains:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIGIT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TIGIT Gene

GeneLoc Exon Structure for
TIGIT
ECgene alternative splicing isoforms for
TIGIT

Expression for TIGIT Gene

mRNA expression in normal human tissues for TIGIT Gene

mRNA differential expression in normal tissues according to GTEx for TIGIT Gene

This gene is overexpressed in Whole Blood (x15.3), Spleen (x8.7), and Small Intestine - Terminal Ileum (x5.4).

Protein differential expression in normal tissues from HIPED for TIGIT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGIT Gene



SOURCE GeneReport for Unigene cluster for TIGIT Gene Hs.421750

mRNA Expression by UniProt/SwissProt for TIGIT Gene

Q495A1-TIGIT_HUMAN
Tissue specificity: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).
genes like me logo Genes that share expression patterns with TIGIT: view

Protein tissue co-expression partners for TIGIT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TIGIT Gene

Orthologs for TIGIT Gene

This gene was present in the common ancestor of mammals.

Orthologs for TIGIT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIGIT 35
  • 77.64 (n)
  • 67.08 (a)
TIGIT 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIGIT 35
  • 77.05 (n)
  • 66.39 (a)
TIGIT 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tigit 35
  • 75.31 (n)
  • 61.51 (a)
Tigit 16
Tigit 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIGIT 35
  • 98.5 (n)
  • 98.36 (a)
TIGIT 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tigit 35
  • 73.81 (n)
  • 59.66 (a)
oppossum
(Monodelphis domestica)
Mammalia TIGIT 36
  • 37 (a)
OneToOne
Species with no ortholog for TIGIT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGIT Gene

ENSEMBL:
Gene Tree for TIGIT (if available)
TreeFam:
Gene Tree for TIGIT (if available)

Paralogs for TIGIT Gene

No data available for Paralogs for TIGIT Gene

Variants for TIGIT Gene

Sequence variations from dbSNP and Humsavar for TIGIT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13098836 - 114,295,580(+) GGAAC(A/G)TTTCT reference, missense
rs1039523 -- 114,299,206(-) AATTC(A/G)AAATT intron-variant
rs1039524 -- 114,293,427(-) ACTTT(A/G)TTGAA upstream-variant-2KB
rs1316642 -- 114,305,216(+) TCAGT(A/G)CACCA intron-variant
rs1405088 -- 114,301,301(-) CAGAA(C/T)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIGIT Gene

Variant ID Type Subtype PubMed ID
esv2043603 CNV Deletion 18987734
esv2725786 CNV Deletion 23290073
esv1507464 CNV Deletion 17803354
esv2742710 CNV Deletion 23290073
nsv822223 CNV Loss 20364138
nsv441835 CNV CNV 18776908

Variation tolerance for TIGIT Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGIT Gene

HapMap Linkage Disequilibrium report
TIGIT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGIT Gene

Disorders for TIGIT Gene

Relevant External Links for TIGIT

Genetic Association Database (GAD)
TIGIT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIGIT

No disorders were found for TIGIT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGIT Gene

Publications for TIGIT Gene

  1. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. (PMID: 19011627) Yu X. … Grogan J.L. (Nat. Immunol. 2009) 2 3 4 67
  2. TIGIT and PD-1 impair tumor antigen-specific CD8a8_ T cells in melanoma patients. (PMID: 25866972) Chauvin J.M. … Zarour H.M. (J. Clin. Invest. 2015) 3
  3. TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals. (PMID: 26171588) Wang F. … Sun Z. (Eur. J. Immunol. 2015) 3
  4. Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. (PMID: 25994968) Fuhrman C.A. … Brusko T.M. (J. Immunol. 2015) 3
  5. Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells. (PMID: 25762785) Bin Dhuban K. … Piccirillo C.A. (J. Immunol. 2015) 3

Products for TIGIT Gene

Sources for TIGIT Gene

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