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Aliases for TIGD7 Gene

Aliases for TIGD7 Gene

  • Tigger Transposable Element Derived 7 2 3 5
  • Tigger Transposable Element-Derived Protein 7 3
  • Sancho 3

External Ids for TIGD7 Gene

Previous GeneCards Identifiers for TIGD7 Gene

  • GC16M003361
  • GC16M003349
  • GC16M003288
  • GC16M003340

Summaries for TIGD7 Gene

Entrez Gene Summary for TIGD7 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD7 Gene

TIGD7 (Tigger Transposable Element Derived 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is JRKL.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD7 Gene

Genomics for TIGD7 Gene

Regulatory Elements for TIGD7 Gene

Enhancers for TIGD7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003148 1.4 Ensembl ENCODE 24 +154.5 154544 4.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC CREBBP THOC6 ZNF213-AS1 ZNF263 LOC105371055 ZNF205 TRAF7 TIGD7 ZNF597 CLUAP1
GH16F003870 1.2 Ensembl ENCODE 21.4 -567.6 -567572 5.4 PKNOX1 ATF1 WRNIP1 ZNF493 ZNF133 YBX1 KLF7 FOS ZNF263 ZNF488 TIGD7 CLUAP1 ZNF213-AS1 FLYWCH2 TRAP1 MTCO1P28 MTND1P8 NLRC3 CREBBP ENSG00000262516
GH16F003097 1.8 FANTOM5 Ensembl ENCODE 13.2 +205.6 205643 6.2 MLX CREB3L1 ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF205 CREBBP THOC6 ZNF263 ZNF597 SNHG19 LOC105371055 SNORD60 ZNF213-AS1 ENSG00000200059
GH16F002750 1.1 ENCODE 21.4 +552.7 552657 4.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TIGD7 CLUAP1 ZNF213-AS1 ELOB PRSS33 ENSG00000221719 PRSS41 ZNF205 PRSS27 NME3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIGD7 on UCSC Golden Path with GeneCards custom track

Promoters for TIGD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001503122 328 2399 HDGF PKNOX1 ATF1 CREB3L1 SIN3A ZNF2 ETS1 YY1 ELK1 CBX5

Genomic Location for TIGD7 Gene

3,298,808 bp from pter
3,305,729 bp from pter
6,922 bases
Minus strand

Genomic View for TIGD7 Gene

Genes around TIGD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD7 Gene

Proteins for TIGD7 Gene

  • Protein details for TIGD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 7
    Protein Accession:
    Secondary Accessions:
    • Q9BXZ0

    Protein attributes for TIGD7 Gene

    549 amino acids
    Molecular mass:
    63236 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TIGD7 Gene


neXtProt entry for TIGD7 Gene

Post-translational modifications for TIGD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD7 Gene

Domains & Families for TIGD7 Gene

Gene Families for TIGD7 Gene

Protein Domains for TIGD7 Gene

Suggested Antigen Peptide Sequences for TIGD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DDE-1 domain.
  • Belongs to the tigger transposable element derived protein family.
  • Contains 1 DDE-1 domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD7: view

Function for TIGD7 Gene

Gene Ontology (GO) - Molecular Function for TIGD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TIGD7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIGD7 Gene

Localization for TIGD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD7 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TIGD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD7: view

Pathways & Interactions for TIGD7 Gene

SuperPathways for TIGD7 Gene

No Data Available

Interacting Proteins for TIGD7 Gene

Gene Ontology (GO) - Biological Process for TIGD7 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD7 Gene

Transcripts for TIGD7 Gene

Unigene Clusters for TIGD7 Gene

Tigger transposable element derived 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD7 Gene

No ASD Table

Relevant External Links for TIGD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIGD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIGD7 Gene

This gene is overexpressed in Plasma (25.0), Gallbladder (18.6), and Colon (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIGD7 Gene

Protein tissue co-expression partners for TIGD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD7 Gene:


SOURCE GeneReport for Unigene cluster for TIGD7 Gene:


mRNA Expression by UniProt/SwissProt for TIGD7 Gene:

Tissue specificity: Expressed in all tissues tested. Higher expression in testis and ovary.
genes like me logo Genes that share expression patterns with TIGD7: view

Primer Products

No data available for mRNA differential expression in normal tissues for TIGD7 Gene

Orthologs for TIGD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIGD7 34 35
  • 99.76 (n)
(Canis familiaris)
Mammalia TIGD7 34 35
  • 89.88 (n)
(Bos Taurus)
Mammalia TIGD7 34 35
  • 88.89 (n)
(Monodelphis domestica)
Mammalia TIGD7 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TIGD7 35
  • 60 (a)
(Mus musculus)
Mammalia Jrk 35
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 23 (a)
Species where no ortholog for TIGD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD7 Gene

Gene Tree for TIGD7 (if available)
Gene Tree for TIGD7 (if available)

Paralogs for TIGD7 Gene

Paralogs for TIGD7 Gene

(2) SIMAP similar genes for TIGD7 Gene using alignment to 2 proteins: Pseudogenes for TIGD7 Gene

genes like me logo Genes that share paralogs with TIGD7: view

Variants for TIGD7 Gene

Sequence variations from dbSNP and Humsavar for TIGD7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111249127 -- 3,306,941(+) CATAA(A/G)TTTTA intron-variant, upstream-variant-2KB
rs111422669 -- 3,299,360(+) ATAAT(C/G)CCCAT intron-variant, reference, missense
rs111498047 -- 3,300,848(+) GGCTC(C/T)TGCTC intron-variant, utr-variant-5-prime
rs111703569 -- 3,307,221(+) GCTGG(G/T)ATTAC intron-variant, upstream-variant-2KB
rs111786598 -- 3,306,723(+) AAAAA(-/C)AAAAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TIGD7 Gene

Variant ID Type Subtype PubMed ID
nsv1044147 CNV loss 25217958
nsv1036149 CNV gain 25217958

Variation tolerance for TIGD7 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGD7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD7 Gene

Disorders for TIGD7 Gene

Relevant External Links for TIGD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIGD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD7 Gene

Publications for TIGD7 Gene

  1. Isolation and characterization of a Jerky and JRK/JH8 like gene, tigger transposable element derived 7, TIGD7. (PMID: 15487591) Dou T. … Mao Y. (Biochem. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for TIGD7 Gene

Sources for TIGD7 Gene

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