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Aliases for TIGD7 Gene

Aliases for TIGD7 Gene

  • Tigger Transposable Element Derived 7 2 3 5
  • Sancho 3

External Ids for TIGD7 Gene

Previous GeneCards Identifiers for TIGD7 Gene

  • GC16M003361
  • GC16M003349
  • GC16M003288
  • GC16M003340

Summaries for TIGD7 Gene

Entrez Gene Summary for TIGD7 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD7 Gene

TIGD7 (Tigger Transposable Element Derived 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD7 Gene

Genomics for TIGD7 Gene

Regulatory Elements for TIGD7 Gene

Promoters for TIGD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIGD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIGD7 Gene

Chromosome:
16
Start:
3,298,808 bp from pter
End:
3,305,729 bp from pter
Size:
6,922 bases
Orientation:
Minus strand

Genomic View for TIGD7 Gene

Genes around TIGD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD7 Gene

Proteins for TIGD7 Gene

  • Protein details for TIGD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT04-TIGD7_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 7
    Protein Accession:
    Q6NT04
    Secondary Accessions:
    • Q9BXZ0

    Protein attributes for TIGD7 Gene

    Size:
    549 amino acids
    Molecular mass:
    63236 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TIGD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIGD7 Gene

Proteomics data for TIGD7 Gene at MOPED

Post-translational modifications for TIGD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD7 Gene

Domains & Families for TIGD7 Gene

Gene Families for TIGD7 Gene

Protein Domains for TIGD7 Gene

Suggested Antigen Peptide Sequences for TIGD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NT04

UniProtKB/Swiss-Prot:

TIGD7_HUMAN :
  • Contains 1 DDE domain.
  • Belongs to the tigger transposable element derived protein family.
Domain:
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD7: view

Function for TIGD7 Gene

Gene Ontology (GO) - Molecular Function for TIGD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD7: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIGD7 Gene

Localization for TIGD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIGD7 Gene COMPARTMENTS Subcellular localization image for TIGD7 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TIGD7 Gene

Pathways & Interactions for TIGD7 Gene

SuperPathways for TIGD7 Gene

No Data Available

Interacting Proteins for TIGD7 Gene

Selected Interacting proteins: Q6NT04-TIGD7_HUMAN for TIGD7 Gene via UniProtKB

Symbol External ID(s) Details
RAB3IL1

Gene Ontology (GO) - Biological Process for TIGD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD7 Gene

Drugs & Compounds for TIGD7 Gene

No Compound Related Data Available

Transcripts for TIGD7 Gene

Unigene Clusters for TIGD7 Gene

Tigger transposable element derived 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD7 Gene

No ASD Table

Relevant External Links for TIGD7 Gene

GeneLoc Exon Structure for
TIGD7
ECgene alternative splicing isoforms for
TIGD7

Expression for TIGD7 Gene

mRNA expression in normal human tissues for TIGD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIGD7 Gene

This gene is overexpressed in Plasma (25.0), Gallbladder (18.6), and Colon (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIGD7 Gene



SOURCE GeneReport for Unigene cluster for TIGD7 Gene Hs.161287

mRNA Expression by UniProt/SwissProt for TIGD7 Gene

Q6NT04-TIGD7_HUMAN
Tissue specificity: Expressed in all tissues tested. Higher expression in testis and ovary.
genes like me logo Genes that share expression patterns with TIGD7: view

Protein tissue co-expression partners for TIGD7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TIGD7 Gene

Orthologs for TIGD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIGD7 35
  • 88.89 (n)
  • 87.32 (a)
TIGD7 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIGD7 35
  • 89.88 (n)
  • 89.4 (a)
TIGD7 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIGD7 35
  • 99.76 (n)
  • 99.64 (a)
TIGD7 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIGD7 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jrk 36
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TIGD7 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
Species with no ortholog for TIGD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD7 Gene

ENSEMBL:
Gene Tree for TIGD7 (if available)
TreeFam:
Gene Tree for TIGD7 (if available)

Paralogs for TIGD7 Gene

Paralogs for TIGD7 Gene

(2) SIMAP similar genes for TIGD7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TIGD7 Gene

genes like me logo Genes that share paralogs with TIGD7: view

Variants for TIGD7 Gene

Sequence variations from dbSNP and Humsavar for TIGD7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs6501167 -- 3,302,651(+) TCAGA(C/G)ATAAA intron-variant
rs6501168 -- 3,302,685(+) TAAAT(A/G)GAAAA intron-variant
rs6501169 -- 3,303,205(+) AGGAA(C/T)GTTTG intron-variant
rs12445388 -- 3,303,112(+) ggatt(A/T)caggt intron-variant
rs36025215 -- 3,302,832(+) CGTCG(G/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIGD7 Gene

Variant ID Type Subtype PubMed ID
dgv2583n71 CNV Loss 21882294

Variation tolerance for TIGD7 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGD7 Gene

HapMap Linkage Disequilibrium report
TIGD7
Human Gene Mutation Database (HGMD)
TIGD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD7 Gene

Disorders for TIGD7 Gene

Relevant External Links for TIGD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIGD7

No disorders were found for TIGD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD7 Gene

Publications for TIGD7 Gene

  1. Isolation and characterization of a Jerky and JRK/JH8 like gene, tigger transposable element derived 7, TIGD7. (PMID: 15487591) Dou T. … Mao Y. (Biochem. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TIGD7 Gene

Sources for TIGD7 Gene

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