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Aliases for TIGD6 Gene

Aliases for TIGD6 Gene

  • Tigger Transposable Element Derived 6 2 3

External Ids for TIGD6 Gene

Previous GeneCards Identifiers for TIGD6 Gene

  • GC05M149442
  • GC05M149960
  • GC05M149355
  • GC05M149401
  • GC05M149352
  • GC05M149372
  • GC05M144520

Summaries for TIGD6 Gene

Entrez Gene Summary for TIGD6 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. [provided by RefSeq, Oct 2009]

GeneCards Summary for TIGD6 Gene

TIGD6 (Tigger Transposable Element Derived 6) is a Protein Coding gene. An important paralog of this gene is TIGD5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD6 Gene

Genomics for TIGD6 Gene

Regulatory Elements for TIGD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIGD6 Gene

149,993,118 bp from pter
150,001,167 bp from pter
8,050 bases
Minus strand

Genomic View for TIGD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIGD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD6 Gene

Proteins for TIGD6 Gene

  • Protein details for TIGD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 6
    Protein Accession:
    Secondary Accessions:
    • B3KTZ8
    • Q96MQ4
    • Q9H0X7

    Protein attributes for TIGD6 Gene

    521 amino acids
    Molecular mass:
    58656 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD6 Gene

Proteomics data for TIGD6 Gene at MOPED

Post-translational modifications for TIGD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD6 Gene

Domains for TIGD6 Gene

Gene Families for TIGD6 Gene

Suggested Antigen Peptide Sequences for TIGD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DDE domain.
  • Belongs to the tigger transposable element derived protein family.
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD6: view

Function for TIGD6 Gene

Gene Ontology (GO) - Molecular Function for TIGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD6: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TIGD6 Gene

Localization for TIGD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD6 Gene

Subcellular locations from

Jensen Localization Image for TIGD6 Gene COMPARTMENTS Subcellular localization image for TIGD6 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TIGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with TIGD6: view

Pathways for TIGD6 Gene

SuperPathways for TIGD6 Gene

No Data Available

Interacting Proteins for TIGD6 Gene

Gene Ontology (GO) - Biological Process for TIGD6 Gene


No data available for Pathways by source for TIGD6 Gene

Transcripts for TIGD6 Gene

Unigene Clusters for TIGD6 Gene

Tigger transposable element derived 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: - -
SP3: -

Relevant External Links for TIGD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD6 Gene

mRNA expression in normal human tissues for TIGD6 Gene

Protein differential expression in normal tissues for TIGD6 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIGD6 Gene

SOURCE GeneReport for Unigene cluster for TIGD6 Gene Hs.169333

genes like me logo Genes that share expressions with TIGD6: view

Expression partners for TIGD6 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIGD6 Gene

Orthologs for TIGD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIGD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TIGD6 35
  • 90.34 (n)
  • 89.64 (a)
TIGD6 36
  • 89 (a)
(Pan troglodytes)
Mammalia TIGD6 35
  • 99.62 (n)
  • 99.04 (a)
TIGD6 36
  • 99 (a)
(Monodelphis domestica)
Mammalia TIGD6 36
  • 83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDC2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00996 35
  • 46.87 (n)
  • 38.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cbh2 35
  • 45.91 (n)
  • 31.76 (a)
Species with no ortholog for TIGD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD6 Gene

Gene Tree for TIGD6 (if available)
Gene Tree for TIGD6 (if available)

Paralogs for TIGD6 Gene

Paralogs for TIGD6 Gene

(2) SIMAP similar genes for TIGD6 Gene using alignment to 1 proteins: Pseudogenes for TIGD6 Gene

genes like me logo Genes that share paralogs with TIGD6: view

Variants for TIGD6 Gene

Sequence variations from dbSNP and Humsavar for TIGD6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs973077 -- 149,993,577(+) TCTTA(C/T)TAAtt utr-variant-3-prime
rs973078 -- 149,993,940(+) caaac(A/G)aacga utr-variant-3-prime
rs3832324 -- 149,995,317(+) TCTTC(-/T)TGATC frameshift-variant, reference
rs4705104 -- 149,998,447(+) GATAG(A/G)TGCTT intron-variant
rs6868575 -- 149,993,659(+) ttccc(A/G)atgtg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIGD6 Gene

Variant ID Type Subtype PubMed ID
esv24664 CNV Gain+Loss 19812545
nsv830518 CNV Loss 17160897
esv2663277 CNV Deletion 23128226

Relevant External Links for TIGD6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD6 Gene

Disorders for TIGD6 Gene

No disorders were found for TIGD6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TIGD6 Gene

Publications for TIGD6 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for TIGD6 Gene

Sources for TIGD6 Gene

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