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Aliases for TIGD6 Gene

Aliases for TIGD6 Gene

  • Tigger Transposable Element Derived 6 2 3 5

External Ids for TIGD6 Gene

Previous GeneCards Identifiers for TIGD6 Gene

  • GC05M149442
  • GC05M149960
  • GC05M149355
  • GC05M149401
  • GC05M149352
  • GC05M149372
  • GC05M144520

Summaries for TIGD6 Gene

Entrez Gene Summary for TIGD6 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. [provided by RefSeq, Oct 2009]

GeneCards Summary for TIGD6 Gene

TIGD6 (Tigger Transposable Element Derived 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

Additional gene information for TIGD6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD6 Gene

Genomics for TIGD6 Gene

Regulatory Elements for TIGD6 Gene

Enhancers for TIGD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H149449 2 FANTOM5 Ensembl ENCODE dbSUPER 46.4 +547.7 547700 8 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B YBX1 DMAP1 SLC30A9 TCOF1 HMGXB3 TIGD6 RPS20P4 CARMN RPL7P1 CSNK1A1 PDGFRB RPS14 ARHGEF37
GH05H149956 2 FANTOM5 Ensembl ENCODE dbSUPER 39.1 +41.5 41518 6 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 ZBTB7B YY1 HMGXB3 TCOF1 ZNF300 ZNF300P1 TIGD6 RPL7P1 CSNK1A1 RPS20P4 PDGFRB SLC26A2
GH05H149209 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.5 +787.3 787328 8 ZNF493 ZFP64 BMI1 ZNF354C RCOR1 FOS ZNF654 ZNF680 ZC3H11A CEBPB HMGXB3 AFAP1L1 TIGD6 FBXO38 RPS20P4 ENSG00000251330 LOC102546294 RPL7P1 ENSG00000253406 ENSG00000248647
GH05H149999 1.7 FANTOM5 ENCODE dbSUPER 17.1 +0.1 97 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 HMGXB3 TCOF1 ZNF300P1 ZNF300 TIGD6 CARMN RPS20P4 RPL7P1 RBM22 CAMK2A
GH05H150025 1.3 ENCODE dbSUPER 18.3 -25.3 -25297 2 HDGF FOXA2 ATF1 MLX ARNT ARID4B DMAP1 TCF12 GATA2 ATF7 HMGXB3 TIGD6 PDGFRB CDX1 RPS20P4 GC05P150052
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIGD6 on UCSC Golden Path with GeneCards custom track

Promoters for TIGD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000188892 167 2401 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for TIGD6 Gene

Chromosome:
5
Start:
149,993,118 bp from pter
End:
150,001,167 bp from pter
Size:
8,050 bases
Orientation:
Minus strand

Genomic View for TIGD6 Gene

Genes around TIGD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD6 Gene

Proteins for TIGD6 Gene

  • Protein details for TIGD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RP2-TIGD6_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 6
    Protein Accession:
    Q17RP2
    Secondary Accessions:
    • B3KTZ8
    • Q96MQ4
    • Q9H0X7

    Protein attributes for TIGD6 Gene

    Size:
    521 amino acids
    Molecular mass:
    58656 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD6 Gene

Post-translational modifications for TIGD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD6 Gene

Domains & Families for TIGD6 Gene

Suggested Antigen Peptide Sequences for TIGD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RP2

UniProtKB/Swiss-Prot:

TIGD6_HUMAN :
  • Belongs to the tigger transposable element derived protein family.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD6: view

Function for TIGD6 Gene

Phenotypes From GWAS Catalog for TIGD6 Gene

Gene Ontology (GO) - Molecular Function for TIGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD6: view
genes like me logo Genes that share phenotypes with TIGD6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TIGD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD6 Gene

Localization for TIGD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD6 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with TIGD6: view

Pathways & Interactions for TIGD6 Gene

SuperPathways for TIGD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIGD6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD6 Gene

Drugs & Compounds for TIGD6 Gene

No Compound Related Data Available

Transcripts for TIGD6 Gene

Unigene Clusters for TIGD6 Gene

Tigger transposable element derived 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TIGD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: - -
SP2:
SP3: -

Relevant External Links for TIGD6 Gene

GeneLoc Exon Structure for
TIGD6
ECgene alternative splicing isoforms for
TIGD6

Expression for TIGD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIGD6 Gene

Protein differential expression in normal tissues from HIPED for TIGD6 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGD6 Gene



Protein tissue co-expression partners for TIGD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD6 Gene:

TIGD6

SOURCE GeneReport for Unigene cluster for TIGD6 Gene:

Hs.169333

Evidence on tissue expression from TISSUES for TIGD6 Gene

  • Intestine(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TIGD6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD6 Gene

Orthologs for TIGD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIGD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIGD6 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia TIGD6 33 34
  • 90.34 (n)
oppossum
(Monodelphis domestica)
Mammalia TIGD6 34
  • 83 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDC2 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00996 33
  • 46.87 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cbh2 33
  • 45.91 (n)
Species where no ortholog for TIGD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD6 Gene

ENSEMBL:
Gene Tree for TIGD6 (if available)
TreeFam:
Gene Tree for TIGD6 (if available)

Paralogs for TIGD6 Gene

Paralogs for TIGD6 Gene

(2) SIMAP similar genes for TIGD6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TIGD6 Gene

genes like me logo Genes that share paralogs with TIGD6: view

Variants for TIGD6 Gene

Sequence variations from dbSNP and Humsavar for TIGD6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000118570 -- 149,999,404(+) CTGTG(C/T)AAAGA intron-variant, upstream-variant-2KB
rs1000188063 -- 150,000,665(+) CGCCA(A/G)GGGTC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000679417 -- 150,000,241(+) CCAGT(A/G)GGAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000980030 -- 150,000,466(+) CCGCC(C/T)CTGTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001527020 -- 149,995,415(+) TGGCT(A/G)CAGGA reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for TIGD6 Gene

Variant ID Type Subtype PubMed ID
esv24664 CNV gain+loss 19812545
esv2663277 CNV deletion 23128226
nsv830518 CNV loss 17160897

Variation tolerance for TIGD6 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIGD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD6 Gene

Disorders for TIGD6 Gene

Relevant External Links for TIGD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIGD6

No disorders were found for TIGD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD6 Gene

Publications for TIGD6 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for TIGD6 Gene

Sources for TIGD6 Gene

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