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Aliases for TIGD6 Gene

Aliases for TIGD6 Gene

  • Tigger Transposable Element Derived 6 2 3 5

External Ids for TIGD6 Gene

Previous GeneCards Identifiers for TIGD6 Gene

  • GC05M149442
  • GC05M149960
  • GC05M149355
  • GC05M149401
  • GC05M149352
  • GC05M149372
  • GC05M144520

Summaries for TIGD6 Gene

Entrez Gene Summary for TIGD6 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. [provided by RefSeq, Oct 2009]

GeneCards Summary for TIGD6 Gene

TIGD6 (Tigger Transposable Element Derived 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD6 Gene

Genomics for TIGD6 Gene

Regulatory Elements for TIGD6 Gene

Enhancers for TIGD6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TIGD6 on UCSC Golden Path with GeneCards custom track

Promoters for TIGD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIGD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIGD6 Gene

Chromosome:
5
Start:
149,993,118 bp from pter
End:
150,001,167 bp from pter
Size:
8,050 bases
Orientation:
Minus strand

Genomic View for TIGD6 Gene

Genes around TIGD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD6 Gene

Proteins for TIGD6 Gene

  • Protein details for TIGD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RP2-TIGD6_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 6
    Protein Accession:
    Q17RP2
    Secondary Accessions:
    • B3KTZ8
    • Q96MQ4
    • Q9H0X7

    Protein attributes for TIGD6 Gene

    Size:
    521 amino acids
    Molecular mass:
    58656 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD6 Gene

Proteomics data for TIGD6 Gene at MOPED

Post-translational modifications for TIGD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD6 Gene

Domains & Families for TIGD6 Gene

Gene Families for TIGD6 Gene

Suggested Antigen Peptide Sequences for TIGD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RP2

UniProtKB/Swiss-Prot:

TIGD6_HUMAN :
  • Contains 1 DDE domain.
  • Belongs to the tigger transposable element derived protein family.
Domain:
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD6: view

Function for TIGD6 Gene

genes like me logo Genes that share phenotypes with TIGD6: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD6 Gene

Localization for TIGD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIGD6 Gene COMPARTMENTS Subcellular localization image for TIGD6 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TIGD6 Gene

Pathways & Interactions for TIGD6 Gene

SuperPathways for TIGD6 Gene

No Data Available

Interacting Proteins for TIGD6 Gene

Gene Ontology (GO) - Biological Process for TIGD6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD6 Gene

Drugs & Compounds for TIGD6 Gene

No Compound Related Data Available

Transcripts for TIGD6 Gene

Unigene Clusters for TIGD6 Gene

Tigger transposable element derived 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: - -
SP2:
SP3: -

Relevant External Links for TIGD6 Gene

GeneLoc Exon Structure for
TIGD6
ECgene alternative splicing isoforms for
TIGD6

Expression for TIGD6 Gene

mRNA expression in normal human tissues for TIGD6 Gene

Protein differential expression in normal tissues from HIPED for TIGD6 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGD6 Gene



SOURCE GeneReport for Unigene cluster for TIGD6 Gene Hs.169333

genes like me logo Genes that share expression patterns with TIGD6: view

Protein tissue co-expression partners for TIGD6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIGD6 Gene

Orthologs for TIGD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIGD6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TIGD6 35
  • 90.34 (n)
  • 89.64 (a)
TIGD6 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIGD6 35
  • 99.62 (n)
  • 99.04 (a)
TIGD6 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIGD6 36
  • 83 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDC2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00996 35
  • 46.87 (n)
  • 38.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cbh2 35
  • 45.91 (n)
  • 31.76 (a)
Species with no ortholog for TIGD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD6 Gene

ENSEMBL:
Gene Tree for TIGD6 (if available)
TreeFam:
Gene Tree for TIGD6 (if available)

Paralogs for TIGD6 Gene

Paralogs for TIGD6 Gene

(2) SIMAP similar genes for TIGD6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TIGD6 Gene

genes like me logo Genes that share paralogs with TIGD6: view

Variants for TIGD6 Gene

Sequence variations from dbSNP and Humsavar for TIGD6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs9324636 - 149,996,174(+) CTCCC(A/G)CACCT reference, missense
rs10875553 - 149,995,369(+) GGCTC(C/T)GGTAC reference, missense
rs973077 -- 149,993,577(+) TCTTA(C/T)TAAtt utr-variant-3-prime
rs973078 -- 149,993,940(+) caaac(A/G)aacga utr-variant-3-prime
rs3832324 -- 149,995,317(+) TCTTC(-/T)TGATC reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for TIGD6 Gene

Variant ID Type Subtype PubMed ID
esv24664 CNV Gain+Loss 19812545
nsv830518 CNV Loss 17160897
esv2663277 CNV Deletion 23128226

Variation tolerance for TIGD6 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TIGD6 Gene

Disorders for TIGD6 Gene

Relevant External Links for TIGD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIGD6

No disorders were found for TIGD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD6 Gene

Publications for TIGD6 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TIGD6 Gene

Sources for TIGD6 Gene

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