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Aliases for TIGD6 Gene

Aliases for TIGD6 Gene

  • Tigger Transposable Element Derived 6 2 3 5

External Ids for TIGD6 Gene

Previous GeneCards Identifiers for TIGD6 Gene

  • GC05M149442
  • GC05M149960
  • GC05M149355
  • GC05M149401
  • GC05M149352
  • GC05M149372
  • GC05M144520

Summaries for TIGD6 Gene

Entrez Gene Summary for TIGD6 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. [provided by RefSeq, Oct 2009]

GeneCards Summary for TIGD6 Gene

TIGD6 (Tigger Transposable Element Derived 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

Additional gene information for TIGD6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD6 Gene

Genomics for TIGD6 Gene

GeneHancer (GH) Regulatory Elements for TIGD6 Gene

Promoters and enhancers for TIGD6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I149999 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 567.2 +0.1 97 3.5 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 HMGXB3 TIGD6 ZNF300P1 TCOF1 RPS20P4 RPL7P1 ZNF300 CAMK2A
GH05I149956 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.1 +41.5 41518 6.7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 SLC26A2 PDE6A HMGXB3 TCOF1 ZNF300 ZNF300P1 TIGD6 RPL7P1 CSNK1A1 RPS20P4
GH05I149209 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.5 +787.3 787327 8.5 ZNF493 ZNF529 ZFP64 BMI1 ZNF354C RCOR1 FOS ZNF680 ZNF654 ZBTB11 HMGXB3 FBXO38 ENSG00000251330 AFAP1L1 TIGD6 LOC102546294 RPS20P4 RPL7P1 ENSG00000248647 ENSG00000253406
GH05I149546 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +451.2 451238 6.2 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 ARHGEF37 CSNK1A1 HMGXB3 RPL7P1 RPS14 TIGD6 TCOF1 RPL29P14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIGD6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIGD6 gene promoter:

Genomic Locations for TIGD6 Gene

Genomic Locations for TIGD6 Gene
8,050 bases
Minus strand

Genomic View for TIGD6 Gene

Genes around TIGD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD6 Gene

Proteins for TIGD6 Gene

  • Protein details for TIGD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 6
    Protein Accession:
    Secondary Accessions:
    • B3KTZ8
    • Q96MQ4
    • Q9H0X7

    Protein attributes for TIGD6 Gene

    521 amino acids
    Molecular mass:
    58656 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD6 Gene

Post-translational modifications for TIGD6 Gene

No Post-translational modifications

Other Protein References for TIGD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD6 Gene

Domains & Families for TIGD6 Gene

Suggested Antigen Peptide Sequences for TIGD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tigger transposable element derived protein family.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD6: view

Function for TIGD6 Gene

Phenotypes From GWAS Catalog for TIGD6 Gene

Gene Ontology (GO) - Molecular Function for TIGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD6: view
genes like me logo Genes that share phenotypes with TIGD6: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD6 Gene

Localization for TIGD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD6 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with TIGD6: view

Pathways & Interactions for TIGD6 Gene

SuperPathways for TIGD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIGD6 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD6 Gene

Drugs & Compounds for TIGD6 Gene

No Compound Related Data Available

Transcripts for TIGD6 Gene

Unigene Clusters for TIGD6 Gene

Tigger transposable element derived 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: - -
SP3: -

Relevant External Links for TIGD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIGD6 Gene

Protein differential expression in normal tissues from HIPED for TIGD6 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGD6 Gene

Protein tissue co-expression partners for TIGD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD6 Gene:


SOURCE GeneReport for Unigene cluster for TIGD6 Gene:


Evidence on tissue expression from TISSUES for TIGD6 Gene

  • Intestine(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TIGD6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD6 Gene

Orthologs for TIGD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIGD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIGD6 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia TIGD6 33 34
  • 90.34 (n)
(Monodelphis domestica)
Mammalia TIGD6 34
  • 83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDC2 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00996 33
  • 46.87 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cbh2 33
  • 45.91 (n)
Species where no ortholog for TIGD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD6 Gene

Gene Tree for TIGD6 (if available)
Gene Tree for TIGD6 (if available)

Paralogs for TIGD6 Gene

Paralogs for TIGD6 Gene

(2) SIMAP similar genes for TIGD6 Gene using alignment to 1 proteins: Pseudogenes for TIGD6 Gene

genes like me logo Genes that share paralogs with TIGD6: view

Variants for TIGD6 Gene

Sequence variations from dbSNP and Humsavar for TIGD6 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000118570 -- 149,999,404(-) T/C intron_variant
rs1000188063 -- 150,000,665(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000679417 -- 150,000,241(-) G/A 5_prime_UTR_variant, intron_variant
rs1000980030 -- 150,000,466(-) C/T 5_prime_UTR_variant, intron_variant
rs1001527020 -- 149,995,415(-) G/A coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for TIGD6 Gene

Variant ID Type Subtype PubMed ID
esv24664 CNV gain+loss 19812545
esv2663277 CNV deletion 23128226
nsv830518 CNV loss 17160897

Variation tolerance for TIGD6 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD6 Gene

Disorders for TIGD6 Gene

Additional Disease Information for TIGD6

No disorders were found for TIGD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD6 Gene

Publications for TIGD6 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for TIGD6 Gene

Sources for TIGD6 Gene

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