TIGD6 Gene
protein-coding GIFtS: 45
GCID: GC05M149372
|
|
tigger transposable element derived 6
| |
Aliases
for TIGD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Tigger Transposable Element Derived 61 2 | | DKFZp761E21101 | | Tigger Transposable Element-Derived Protein 62 |
| External Ids: | HGNC: 183321 | Entrez Gene: 817892 | Ensembl: ENSG000001642967 | UniProtKB: Q17RP23 | | ORGUL members: | |
|---|
| NONCODE:n410901 | |
Export aliases for TIGD6 gene to outside databasesPrevious GC identifers: GC05M149442 GC05M149960 GC05M149355 GC05M149401 GC05M149352 GC05M144520
|---|
Summaries
for TIGD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TIGD6:
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons inhumans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 andmariner transposases. They are also very similar to the major mammalian centromere protein B. (provided by RefSeq, Oct2009)
|
Genomic Views
for TIGD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TIGD6 gene promoter:
AhR PPAR-alpha AML1a Brachyury Sox9 AP-4 CUTL1 LyF-1 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIGD6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q33.1TIGD6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M149372: view genomic region
(about GC identifiers)
Start:
|
149,372,681 bp from pter |
End:
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149,380,730 bp from pter |
Size:
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8,050 bases |
Orientation:
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minus strand |
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Proteins
for TIGD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIGD6_HUMAN, Q17RP2 (See
protein sequence)Recommended Name: Tigger transposable element-derived protein 6 Size: 521 amino acids; 58656 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B3KTZ8 Q96MQ4 Q9H0X7Explore the universe of human proteins at neXtProt for TIGD6: NX_Q17RP2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q17RP2
TIGD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001230182.1 NP_112215.1
ENSEMBL proteins: ENSP00000296736 ENSP00000425318
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
TIGD6 for ontologies About GeneDecksing
TIGD6 Antibody Products:
Assay Products for TIGD6: |
Protein
Domains /
Families
for TIGD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIGD6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q17RP2ProtoNet protein and cluster: Q17RP2 2 Blocks protein families: IPB004875 CENP-B protein IPB006695 CENP-B
UniProtKB/Swiss-Prot: TIGD6_HUMAN, Q17RP2Similarity: Belongs to the tigger transposable element derived protein familySimilarity: Contains 1 DDE domainSimilarity: Contains 1 HTH CENPB-type DNA-binding domainSimilarity: Contains 1 HTH psq-type DNA-binding domain |
Function
for TIGD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
TIGD6 for ontologies About GeneDecksing
|
Pathways & Interactions
for TIGD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIGD6
|
Drugs & Compounds
for TIGD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TIGD6
Search CenterWatch for drugs/clinical trials and news about TIGD6
|
Transcripts
for TIGD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TIGD6 gene (2 alternative transcripts): NM_001243253.1 NM_030953.3 Unigene Cluster for TIGD6: Tigger transposable element derived 6 Hs.169333 [show with all ESTs]Unigene Representative Sequence: NM_0309533 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296736(uc003lri.3 uc003lrj.3) ENST00000515406 ENST00000532987
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TIGD6 (NM_030953) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIGD6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD6 |
Additional cDNA sequence: AK056604.1 AK092978.1 AK096325.1 AL136539.1 BC033641.1 BC062669.1 BC117249.1 CR533559.1 4 DOTS entries: DT.216158 DT.409381 DT.97835733 DT.100020770 24/42 AceView cDNA sequences (see all 42): CR533559 CR604620 BM474491 NM_030953 AA031477 AA363947 BM701979 BU729644 AA418909 AL136539 BX110310 AA426555 BX393613 BI771197 BX457884 AK096325 AK092978 H44364 BC033641 BG824417 BU959649 AK056604 AW207888 BX342242
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TIGD6 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for TIGD6
|
Expression
for TIGD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIGD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCTGGCG
About this image
See TIGD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIGD6
SOURCE GeneReport for Unigene cluster: Hs.169333
SABiosciences Custom PCR Arrays for TIGD6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIGD6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TIGD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIGD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGD6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD6 |
Orthologs
for TIGD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TIGD6 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mosquito
(Anopheles gambiae) |
Insecta |
AgaP_AGAP0019061 |
AGAP001906-PA |
43.67(n)
29.72(a) |
|
1281221 XM_321159.4 XP_321159.4 |
Species with no ortholog for TIGD6
ENSEMBL Gene Tree for TIGD6 (if available)
TreeFam Gene Tree for TIGD6 (if available) |
Paralogs
for TIGD6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TIGD6 gene
- TIGD22 TIGD12 CENPB2 TIGD42 TIGD72 JRKL2 TIGD52 TIGD32
2 SIMAP similar genes for TIGD6 using alignment to 1 protein entry: TIGD6_HUMAN:TIGD4 CENPB
TIGD6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TIGD6
PGOHUM00000243701
|
Genomic Variants
for TIGD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TIGD6 (149372681 - 149380730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TIGD6
1 CNV: 69220 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIGD6 |
|
Disorders
/ Diseases
for TIGD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TIGD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIGD6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TIGD6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
- DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
|
External Searches for TIGD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TIGD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIGD6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIGD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TIGD6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TIGD6 gene:
Search GeneIP for patents involving TIGD6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIGD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | Search Tocris compounds for TIGD6 |
| |  |  |  |  | | | | |
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 | | | TIGD6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD6 |
|  |  |  | | | | ThermoFisher Antibodies for TIGD6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD6 |
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