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TIGD5 Gene

protein-coding   GIFtS: 42
GCID: GC08P144680

Tigger Transposable Element Derived 5

  Search for TIGD5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tigger Transposable Element Derived 51 2
Tigger Transposable Element-Derived Protein 52

External Ids:    HGNC: 183361   Entrez Gene: 849482   Ensembl: ENSG000001798867   UniProtKB: Q53EQ63   

Export aliases for TIGD5 gene to outside databases

Previous GC identifers: GC08P142725 GC08P144908 GC08P144454 GC08P144785 GC08P144751 GC08P139914


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIGD5 Gene:
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated
transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more
distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere
protein B. The exact function of this gene is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIGD5 Gene:
TIGD5 (tigger transposable element derived 5) is a protein-coding gene. An important paralog of this gene is TIGD2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  NT_187571.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIGD5 gene promoter:
         GCNF   AP-4   YY1   CREB   E2F-1   E2F   GCNF-1   STAT3   ZIC2/Zic2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIGD5 promoter sequence
   Search Chromatin IP Primers for TIGD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIGD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

TIGD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIGD5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144680:  view genomic region     (about GC identifiers)

Start:
144,680,074 bp from pter      End:
144,682,485 bp from pter
Size:
2,412 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIGD5_HUMAN, Q53EQ6 (See protein sequence)
Recommended Name: Tigger transposable element-derived protein 5  
Size: 642 amino acids; 69222 Da
Sequence caution: Sequence=AAH32632.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB55398.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD97303.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: E7EWS2 Q6NT83 Q8N5A1 Q96JW8
Alternative splicing: 2 isoforms:  Q53EQ6-1   Q53EQ6-2   

Explore the universe of human proteins at neXtProt for TIGD5: NX_Q53EQ6

Explore proteomics data for TIGD5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIGD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116251.4  
    ENSEMBL proteins: 
     ENSP00000421489   ENSP00000315906  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR006600 HTH_CenpB_DNA-bd_dom
     IPR004875 DDE_SF_endonuclease_CENPB-like
     IPR009057 Homeodomain-like
     IPR007889 HTH_Psq

    Graphical View of Domain Structure for InterPro Entry Q53EQ6

    ProtoNet protein and cluster: Q53EQ6

    1 Blocks protein domain: IPB004875 CENP-B protein

    UniProtKB/Swiss-Prot: TIGD5_HUMAN, Q53EQ6
    Similarity: Belongs to the tigger transposable element derived protein family
    Similarity: Contains 2 DDE domains
    Similarity: Contains 1 HTH CENPB-type DNA-binding domain
    Similarity: Contains 1 HTH psq-type DNA-binding domain


    TIGD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
         
    TIGD5 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTIGD5 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIGD5_HUMAN, Q53EQ6: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    TIGD5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIGD5
    Interactions:

        Search GeneGlobe Interaction Network for TIGD5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TIGD5 (ENSP000003159064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    TIGD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIGD5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TIGD5 gene: 
    NM_032862.4  

    Unigene Cluster for TIGD5:

    Tigger transposable element derived 5
    Hs.71574  [show with all ESTs]
    Unigene Representative Sequence: NM_032862
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504548 ENST00000321385(uc003yyx.2)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TIGD5:
    hsa-miR-152 hsa-miR-199a-5p hsa-miR-148b hsa-miR-199b-5p hsa-miR-3118 hsa-miR-134 hsa-miR-1825 hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidTIGD5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TIGD5
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TIGD5
      QuantiFast Probe-based Assays in human, mouse, rat TIGD5

    Additional mRNA sequence: 

    AK027832.1 AK223583.1 BC032632.1 BC069229.1 

    1 DOTS entry:

    DT.453841 

    Selected AceView cDNA sequences (see all 43):

    BM727243 NM_032862 AI648562 AI133279 BE350277 CB055230 CB055231 BC069229 
    BM049601 BM915841 AW665438 BU740809 BI857753 BV202302 BX113218 AI733896 
    AI376573 BM471048 BM556133 BC032632 AW151443 AK027832 AI991797 AA622968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIGD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTGGACGA
    TIGD5 Expression
    About this image

    TIGD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIGD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.71574
        Custom PCR Arrays for TIGD5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TIGD5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tigd51 , 5 tigger transposable element derived 51, 5 81.53(n)1
    85.93(a)1
      15 (35.07 cM)5
    1057341  NM_178646.41  NP_848761.21 
     759097605 
    chicken
    (Gallus gallus)
    Aves TIGD51 tigger transposable element derived 5 68.5(n)
    73.95(a)
      101749031  XM_004940092.1  XP_004940149.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    21(a)
    many ↔ many
    2(103059200-103060456)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tigd51 tigger transposable element derived 5 64.48(n)
    65.67(a)
      100491467  XM_004915012.1  XP_004915069.1 


    ENSEMBL Gene Tree for TIGD5 (if available)
    TreeFam Gene Tree for TIGD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIGD5 gene
    TIGD22  JRKL2  TIGD12  TIGD72  CENPB2  TIGD62  TIGD32  TIGD42  
    1 SIMAP similar gene for TIGD5 using alignment to 1 protein entry:     TIGD5_HUMAN:
    JH8

    TIGD5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIGD5 (see all 19)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460360861,2
    C--144682235(+) TCAGGA/GCAGGC 1 -- ut310--------
    rs32101861,2
    C,F,A,H--144682311(+) CCGTGG/CGGCTG 1 -- ut3110Minor allele frequency- C:0.38NS EA NA 660
    rs1397868881,2
    --144682351(+) CTGGAC/TGAGGG 1 -- ut310--------
    rs1431742121,2
    C--144682358(+) AGGGCC/TGAAAC 1 -- ut310--------
    rs1126370951,2
    C,F--144682428(+) AGTGGC/TGAAGC 1 -- ut312Minor allele frequency- T:0.04NA 122
    rs1461946161,2
    --144682451(+) TCTATG/TTTTTT 1 -- ut310--------
    rs1484281061,2
    C--144682701(+) TATTCC/TGTGGG 1 -- ds50010--------
    rs65583751,2
    C,F,A--144682748(+) GCCAAC/TGGCAG 1 -- ds500112Minor allele frequency- T:0.26NA WA CSA EA 375
    rs1840647621,2
    --144682877(+) CCACCC/TTCTGT 1 -- ds50010--------
    rs102829291,2,4
    ----see VAR_0300432 mis40--------

    HapMap Linkage Disequilibrium report for TIGD5 (144680074 - 144682485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TIGD5 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv26007CNV Loss19812545
    nsv466004CNV Loss19166990
    dgv7932n71CNV Loss21882294
    nsv516210CNV Loss19592680
    nsv891739CNV Loss21882294
    dgv7936n71CNV Loss21882294
    nsv891734CNV Loss21882294
    dgv7928n71CNV Loss21882294
    dgv7934n71CNV Loss21882294
    dgv7933n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIGD5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TIGD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84948 HGNC: 18336 AceView: TIGD5 Ensembl:ENSG00000179886 euGenes: HUgn84948
    ECgene: TIGD5 H-InvDB: TIGD5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIGD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIGD5 gene:
    Search GeneIP for patents involving TIGD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TIGD5  
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     Block miRNA regulation of human, mouse, rat TIGD5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TIGD5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIGD5 Predesigned siRNA for gene silencing in human, mouse, rat TIGD5
     QuantiFast Probe-based Assays in human, mouse, rat TIGD5 QuantiTect SYBR Green Assays in human, mouse, rat TIGD5
     Custom PCR Arrays for TIGD5 Search Chromatin IP Primers for TIGD5
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     SwitchGear 3'UTR luciferase reporter plasmids for TIGD5
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     ThermoFisher Antibodies for TIGD5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIGD5
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     Search LSBio for Antibodies for TIGD5
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