Aliases for TIGD5 Gene
External Ids for TIGD5 Gene
- HGNC: 18336
- Entrez Gene: 84948
- Ensembl: ENSG00000179886
- UniProtKB: Q53EQ6
Previous GeneCards Identifiers for TIGD5 Gene
- GC08P142725
- GC08P144908
- GC08P144454
- GC08P144785
- GC08P144751
- GC08P144680
- GC08P139914
Summaries for TIGD5 Gene
-
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIGD5 Gene
TIGD5 (Tigger Transposable Element Derived 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is JRKL.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD5 Gene
Genomics for TIGD5 Gene
GeneHancer (GH) Regulatory Elements for TIGD5 Gene
Promoters and enhancers for TIGD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TIGD5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TIGD5 Gene
Genomic Locations for TIGD5 Gene
- chr8:143,597,835-143,603,224
- (GRCh38/hg38)
- Size:
- 5,390 bases
- Orientation:
- Plus strand
- chr8:144,680,074-144,682,485
- (GRCh37/hg19)
Genomic View for TIGD5 Gene
Genes around TIGD5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
TIGD5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIGD5 Gene
Proteins for TIGD5 Gene
-
Protein details for TIGD5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q53EQ6-TIGD5_HUMAN
- Recommended name:
- Tigger transposable element-derived protein 5
- Protein Accession:
- Q53EQ6
- E7EWS2
- Q6NT83
- Q8N5A1
- Q96JW8
Protein attributes for TIGD5 Gene
- Size:
- 642 amino acids
- Molecular mass:
- 69222 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH32632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for TIGD5 Gene
Post-translational modifications for TIGD5 Gene
No Post-translational modifications
Other Protein References for TIGD5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TIGD5
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-
Quality Products:
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-
Abcam proteins for TIGD5
Assay Products
No data available for DME Specific Peptides for TIGD5 Gene
Domains & Families for TIGD5 Gene
Gene Families for TIGD5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TIGD5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIGD5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q53EQ6UniProtKB/Swiss-Prot:
TIGD5_HUMAN :- Belongs to the tigger transposable element derived protein family.
- Family:
-
- Belongs to the tigger transposable element derived protein family.
Function for TIGD5 Gene
Phenotypes From GWAS Catalog for TIGD5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for TIGD5 Gene
- GenomeRNAi human phenotypes for TIGD5:
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for TIGD5
- genomics-online: gRNA clones - Search results for 84 available TIGD5 gene related products
- Overview of 84 available TIGD5 gene related products
- Applied Biological Materials CRISPR for TIGD5
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIGD5
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miRNA for TIGD5 Gene
- miRTarBase miRNAs that target TIGD5
-
- hsa-mir-7111-5p (MIRT486369)
- hsa-mir-6870-5p (MIRT486370)
- hsa-mir-5698 (MIRT486371)
- hsa-mir-4723-5p (MIRT486372)
- hsa-mir-6883-5p (MIRT486373)
- hsa-mir-6825-5p (MIRT486374)
- hsa-mir-6785-5p (MIRT486375)
- hsa-mir-4728-5p (MIRT486376)
- hsa-mir-149-3p (MIRT486377)
- hsa-mir-7106-5p (MIRT486378)
- hsa-mir-765 (MIRT486379)
- hsa-mir-4306 (MIRT486380)
- hsa-mir-4644 (MIRT486381)
- hsa-mir-185-5p (MIRT486382)
- hsa-mir-4784 (MIRT486383)
- hsa-mir-3150b-3p (MIRT486384)
- hsa-mir-1273f (MIRT486385)
- hsa-mir-6764-5p (MIRT486386)
- hsa-mir-6798-5p (MIRT486387)
- hsa-mir-1915-3p (MIRT486388)
- hsa-mir-6871-5p (MIRT486389)
- hsa-mir-6794-5p (MIRT486390)
- hsa-mir-4716-3p (MIRT486391)
- hsa-mir-4659b-3p (MIRT707841)
- hsa-mir-4659a-3p (MIRT707842)
- hsa-mir-6875-3p (MIRT707843)
- hsa-mir-3924 (MIRT707844)
- hsa-mir-190a-3p (MIRT707845)
- hsa-mir-5011-5p (MIRT707846)
- hsa-mir-5580-3p (MIRT707847)
- hsa-mir-4325 (MIRT785762)
- hsa-mir-4793-3p (MIRT786800)
- hsa-mir-500a-3p (MIRT786973)
- hsa-mir-6804-3p (MIRT788826)
miRNA Products
- Search ViGene Biosciences for TIGD5
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TIGD5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TIGD5
-
ViGene Biosciences adenoviral particle packaged cDNA for TIGD5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TIGD5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD5 Gene
Localization for TIGD5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIGD5 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIGD5 Gene
Pathways & Interactions for TIGD5 Gene
No Data Available
Interacting Proteins for TIGD5 Gene
Selected Interacting proteins:
Q53EQ6-TIGD5_HUMAN
ENSP00000421489
for TIGD5 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for TIGD5 Gene
Transcripts for TIGD5 Gene
mRNA/cDNA for TIGD5 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (43) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TIGD5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TIGD5
- genomics-online: gRNA clones - Search results for 84 available TIGD5 gene related products
- Overview of 84 available TIGD5 gene related products
- Applied Biological Materials CRISPR for TIGD5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIGD5
- GenScript: Design CRISPR guide RNA sequences for TIGD5
miRNA Products
- Search ViGene Biosciences for TIGD5
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TIGD5
- Browse OriGene Inhibitory RNA Products For TIGD5
- genomics-online: shRNA clones - Search results for 84 available TIGD5 gene related products
- Overview of 84 available TIGD5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TIGD5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIGD5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TIGD5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TIGD5 Gene
This gene is overexpressed in Kidney (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIGD5 Gene
NURSA nuclear receptor signaling pathways regulating expression of TIGD5 Gene:
TIGD5SOURCE GeneReport for Unigene cluster for TIGD5 Gene:
Hs.71574Evidence on tissue expression from TISSUES for TIGD5 Gene
- Kidney(4.1)
- Skin(4)
Primer Products
-
OriGene qPCR primer pairs for TIGD5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD5 Gene
Orthologs for TIGD5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | TIGD5 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TIGD5 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tigd5 33 16 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TIGD5 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tigd5 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TIGD5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TIGD5 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tigd5 33 |
|
- Species where no ortholog for TIGD5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TIGD5 Gene
Variants for TIGD5 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000551410 | -- | 143,597,910(+) | C/A | coding_sequence_variant, missense_variant | |
| rs1001156173 | -- | 143,598,513(+) | A/C/G | coding_sequence_variant, missense_variant | |
| rs1001505088 | -- | 143,595,932(+) | C/T | upstream_transcript_variant | |
| rs1001598335 | -- | 143,596,177(+) | T/A | upstream_transcript_variant | |
| rs1001790227 | -- | 143,598,779(+) | G/A | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12410n54 | CNV | loss | 21841781 |
| dgv12418n54 | CNV | loss | 21841781 |
| dgv12419n54 | CNV | loss | 21841781 |
| dgv12420n54 | CNV | gain | 21841781 |
| dgv12421n54 | CNV | gain | 21841781 |
| dgv12422n54 | CNV | gain | 21841781 |
| dgv12423n54 | CNV | gain+loss | 21841781 |
| dgv12424n54 | CNV | gain+loss | 21841781 |
| dgv12425n54 | CNV | loss | 21841781 |
| dgv12426n54 | CNV | loss | 21841781 |
| dgv7336n100 | CNV | gain | 25217958 |
| esv26007 | CNV | loss | 19812545 |
| nsv1161809 | CNV | deletion | 26073780 |
| nsv1161810 | CNV | deletion | 26073780 |
| nsv466004 | CNV | loss | 19166990 |
| nsv470247 | CNV | loss | 18288195 |
| nsv516210 | CNV | loss | 19592680 |
| nsv612774 | CNV | loss | 21841781 |
| nsv612777 | CNV | gain | 21841781 |
| nsv612793 | CNV | loss | 21841781 |
| nsv612813 | CNV | loss | 21841781 |
| nsv612819 | CNV | gain | 21841781 |
| nsv612820 | CNV | loss | 21841781 |
| nsv612822 | CNV | gain | 21841781 |
| nsv612845 | CNV | gain | 21841781 |
| nsv612847 | CNV | loss | 21841781 |
| nsv612849 | CNV | loss | 21841781 |
| nsv612850 | CNV | loss | 21841781 |
| nsv824771 | CNV | gain | 20364138 |
| nsv831488 | CNV | loss | 17160897 |
| nsv950013 | CNV | deletion | 24416366 |
Gene Damage Index Score:
1.92;
35.76% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TIGD5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TIGD5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD5 Gene
Disorders for TIGD5 Gene
Additional Disease Information for TIGD5
No disorders were found for TIGD5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD5 Gene
Publications for TIGD5 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
Products for TIGD5 Gene
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- VectorBuilder custom plasmid, inducible vectors for TIGD5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIGD5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available TIGD5 related products ranked by validation data
- antibodies-online: Search results for available TIGD5 related products ranked by validation data
- antibodies-online: Search results for 3 available TIGD5 Proteins ranked by validation data
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- Quality Products:
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- Overview of 84 available TIGD5 gene related products
Sources for TIGD5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
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