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Aliases for TIGD5 Gene

Aliases for TIGD5 Gene

  • Tigger Transposable Element Derived 5 2 3 5

External Ids for TIGD5 Gene

Previous GeneCards Identifiers for TIGD5 Gene

  • GC08P142725
  • GC08P144908
  • GC08P144454
  • GC08P144785
  • GC08P144751
  • GC08P144680
  • GC08P139914

Summaries for TIGD5 Gene

Entrez Gene Summary for TIGD5 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD5 Gene

TIGD5 (Tigger Transposable Element Derived 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD5 Gene

Genomics for TIGD5 Gene

Regulatory Elements for TIGD5 Gene

Enhancers for TIGD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TIGD5 on UCSC Golden Path with GeneCards custom track

Promoters for TIGD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIGD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIGD5 Gene

143,597,835 bp from pter
143,603,224 bp from pter
5,390 bases
Plus strand

Genomic View for TIGD5 Gene

Genes around TIGD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD5 Gene

Proteins for TIGD5 Gene

  • Protein details for TIGD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 5
    Protein Accession:
    Secondary Accessions:
    • E7EWS2
    • Q6NT83
    • Q8N5A1
    • Q96JW8

    Protein attributes for TIGD5 Gene

    642 amino acids
    Molecular mass:
    69222 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TIGD5 Gene


neXtProt entry for TIGD5 Gene

Proteomics data for TIGD5 Gene at MOPED

Post-translational modifications for TIGD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD5 Gene

Domains & Families for TIGD5 Gene

Gene Families for TIGD5 Gene

Protein Domains for TIGD5 Gene

Suggested Antigen Peptide Sequences for TIGD5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 DDE domains.
  • Belongs to the tigger transposable element derived protein family.
  • Contains 2 DDE domains.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD5: view

Function for TIGD5 Gene

Gene Ontology (GO) - Molecular Function for TIGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD5: view

Phenotypes for TIGD5 Gene

GenomeRNAi human phenotypes for TIGD5:
genes like me logo Genes that share phenotypes with TIGD5: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD5 Gene

Localization for TIGD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD5 Gene

Subcellular locations from

Jensen Localization Image for TIGD5 Gene COMPARTMENTS Subcellular localization image for TIGD5 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TIGD5 Gene

Pathways & Interactions for TIGD5 Gene

SuperPathways for TIGD5 Gene

No Data Available

Interacting Proteins for TIGD5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000421489 Q53EQ6-TIGD5_HUMAN for TIGD5 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TIGD5 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD5 Gene

Drugs & Compounds for TIGD5 Gene

No Compound Related Data Available

Transcripts for TIGD5 Gene

mRNA/cDNA for TIGD5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD5 Gene

Tigger transposable element derived 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD5 Gene

No ASD Table

Relevant External Links for TIGD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD5 Gene

mRNA expression in normal human tissues for TIGD5 Gene

Protein differential expression in normal tissues from HIPED for TIGD5 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIGD5 Gene

SOURCE GeneReport for Unigene cluster for TIGD5 Gene Hs.71574

genes like me logo Genes that share expression patterns with TIGD5: view

Protein tissue co-expression partners for TIGD5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIGD5 Gene

Orthologs for TIGD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIGD5 35
  • 87.34 (n)
  • 88.42 (a)
TIGD5 36
  • 87 (a)
(Canis familiaris)
Mammalia TIGD5 35
  • 88.95 (n)
  • 90.52 (a)
TIGD5 36
  • 88 (a)
(Mus musculus)
Mammalia Tigd5 35
  • 81.53 (n)
  • 85.93 (a)
Tigd5 16
(Rattus norvegicus)
Mammalia Tigd5 35
  • 79.39 (n)
  • 84.76 (a)
(Monodelphis domestica)
Mammalia TIGD5 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TIGD5 36
  • 80 (a)
(Gallus gallus)
Aves TIGD5 35
  • 68.5 (n)
  • 73.95 (a)
TIGD5 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tigd5 35
  • 64.48 (n)
  • 65.67 (a)
Species with no ortholog for TIGD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD5 Gene

Gene Tree for TIGD5 (if available)
Gene Tree for TIGD5 (if available)

Paralogs for TIGD5 Gene

Paralogs for TIGD5 Gene

(1) SIMAP similar genes for TIGD5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD5: view

Variants for TIGD5 Gene

Sequence variations from dbSNP and Humsavar for TIGD5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_030043 -
rs3210186 -- 143,600,141(+) CCGTG(C/G)GGCTG utr-variant-3-prime
rs6558375 -- 143,600,578(+) GCCAA(C/T)GGCAG downstream-variant-500B
rs111956838 -- 143,599,834(+) GTGAC(C/T)AGGCC utr-variant-3-prime
rs143174212 -- 143,600,188(+) AGGGC(C/T)GAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIGD5 Gene

Variant ID Type Subtype PubMed ID
nsv470247 CNV Loss 18288195
nsv891676 CNV Loss 21882294
dgv7928n71 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
dgv7933n71 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
nsv516210 CNV Loss 19592680
dgv7935n71 CNV Loss 21882294
dgv7936n71 CNV Loss 21882294
dgv7937n71 CNV Loss 21882294
nsv891734 CNV Loss 21882294
nsv891737 CNV Gain 21882294
nsv466004 CNV Loss 19166990
nsv891739 CNV Loss 21882294
nsv831488 CNV Loss 17160897
nsv824771 CNV Gain 20364138
esv26007 CNV Loss 19812545

Variation tolerance for TIGD5 Gene

Gene Damage Index Score: 1.92; 35.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TIGD5 Gene

Disorders for TIGD5 Gene

Relevant External Links for TIGD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIGD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD5 Gene

Publications for TIGD5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TIGD5 Gene

Sources for TIGD5 Gene