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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIGD5 Gene

protein-coding GIFtS: 43
GCID: GC08P144680

Tigger Transposable Element Derived 5

Search for TIGD5
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tigger Transposable Element Derived 5¹ ²
Tigger Transposable Element-Derived Protein 5²

External Ids:	HGNC: 18336¹	Entrez Gene: 84948²	Ensembl: ENSG00000179886⁷	UniProtKB: Q53EQ6³

Export aliases for TIGD5 gene to outside databases

Previous GC identifers: GC08P142725 GC08P144908 GC08P144454 GC08P144785 GC08P144751 GC08P139914

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIGD5 Gene:

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated

transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more

distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere

protein B. The exact function of this gene is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIGD5 Gene:

TIGD5 (tigger transposable element derived 5) is a protein-coding gene. GO annotations related to this gene include DNA binding and molecular_function. An important paralog of this gene is TIGD2.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.2 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIGD5 gene promoter:
GCNF AP-4 YY1 CREB E2F-1 E2F GCNF-1 STAT3 ZIC2/Zic2 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIGD5 promoter sequence

Search SABiosciences Chromatin IP Primers for TIGD5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

TIGD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIGD5 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P144680: view genomic region (about GC identifiers)

Start:	144,680,074 bp from pter	End:	144,682,485 bp from pter
Size:	2,412 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIGD5_HUMAN, Q53EQ6 (See protein sequence)

Recommended Name: Tigger transposable element-derived protein 5

Size: 642 amino acids; 69222 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAH32632.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB55398.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD97303.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: E7EWS2 Q6NT83 Q8N5A1 Q96JW8

Alternative splicing: 2 isoforms: Q53EQ6-1 Q53EQ6-2

Explore the universe of human proteins at neXtProt for TIGD5: NX_Q53EQ6

Explore proteomics data for TIGD5 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q53EQ6

TIGD5 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_116251.4

ENSEMBL proteins:

ENSP00000421489 ENSP00000315906

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--

TIGD5 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro protein domains:

IPR006600 HTH_CenpB_DNA-bd_dom

IPR004875 DDE_SF_endonuclease_CENPB-like

IPR009057 Homeodomain-like

IPR007889 HTH_Psq

Graphical View of Domain Structure for InterPro Entry Q53EQ6

ProtoNet protein and cluster: Q53EQ6

1 Blocks protein domain: IPB004875 CENP-B protein

UniProtKB/Swiss-Prot: TIGD5_HUMAN, Q53EQ6

Similarity: Belongs to the tigger transposable element derived protein family

Similarity: Contains 2 DDE domains

Similarity: Contains 1 HTH CENPB-type DNA-binding domain

Similarity: Contains 1 HTH psq-type DNA-binding domain

TIGD5 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--

TIGD5 for ontologies About GeneDecksing

Animal Models:

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		SwitchGear 3'UTR luciferase reporter plasmid: TIGD5 3' UTR sequence

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TIGD5

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TIGD5 (ENSP00000315906⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

TIGD5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIGD5

Search CenterWatch for drugs/clinical trials and news about TIGD5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TIGD5 gene:

NM_032862.4

Unigene Cluster for TIGD5:

Tigger transposable element derived 5

Hs.71574 [show with all ESTs]

Unigene Representative Sequence: NM_032862

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000504548 ENST00000321385(uc003yyx.2)

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		SwitchGear 3'UTR luciferase reporter plasmid: TIGD5 3' UTR sequence

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Additional mRNA sequence:

AK027832.1 AK223583.1 BC032632.1 BC069229.1

1 DOTS entry:

DT.453841

24/43 AceView cDNA sequences (see all 43):

AI133279 CB055230 NM_032862 BE350277 AI648562 CB055231 BM727243 BC032632

BM049601 AI733896 AK027832 BM915841 BV202302 BX113218 BU740809 AI376573

AW665438 AW151443 AI991797 BI857753 BC069229 BM556133 BM471048 R40682

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIGD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CACTGGACGA

About this image

See TIGD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIGD5

SOURCE GeneReport for Unigene cluster: Hs.71574

SABiosciences Custom PCR Arrays for TIGD5

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TIGD5 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tigd5^{1 , 5}	tigger transposable element derived 5^{1, 5}	82.09(n)¹ 86.01(a)¹		15 (35.07 cM)⁵ 105734¹ NM_178646.4¹ NP_848761.2¹ 75909760⁵
chicken (Gallus gallus)	Aves	TIGD5⁶	tigger transposable element derived 5	60(a)	1 ↔ 1	2(148471391-148473563)

ENSEMBL Gene Tree for TIGD5 (if available)
TreeFam Gene Tree for TIGD5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TIGD5 gene

TIGD2² TIGD1² CENPB² TIGD6² TIGD4² JRKL² TIGD7² TIGD3²

1 SIMAP similar gene for TIGD5 using alignment to 1 protein entry: TIGD5_HUMAN:

JH8

TIGD5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_030043⁴		--	--	see VAR_030043	2	M I	mis⁴		0	--	--	--	--
rs146036086^1,2	C	--	144682235(+)	`TCAGGA/GCAGGC`	1	--	ut3¹		0	--	--	--	--
rs3210186^1,2	C,F,A,H	--	144682311(+)	`CCGTGG/CGGCTG`	1	--	ut3¹		10		NS EA NA	660
rs139786888^1,2		--	144682351(+)	`CTGGAC/TGAGGG`	1	--	ut3¹		0	--	--	--	--
rs143174212^1,2	C	--	144682358(+)	`AGGGCC/TGAAAC`	1	--	ut3¹		0	--	--	--	--
rs112637095^1,2	C,F	--	144682428(+)	`AGTGGC/TGAAGC`	1	--	ut3¹		2		NA	122
rs146194616^1,2		--	144682451(+)	`TCTATG/TTTTTT`	1	--	ut3¹		0	--	--	--	--
rs148428106^1,2	C	--	144682701(+)	`TATTCC/TGTGGG`	1	--	ds500¹		0	--	--	--	--
rs6558375^1,2	C,F,A	--	144682748(+)	`GCCAAC/TGGCAG`	1	--	ds500¹		12		NA WA CSA EA	375
rs184064762^1,2		--	144682877(+)	`CCACCC/TTCTGT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TIGD5 (144680074 - 144682485 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/17 variations for TIGD5 (see all 17): About this table

Variant ID	Type	Subtype	PubMed ID
esv26007	CNV	Loss	19812545
nsv466004	CNV	Loss	19166990
dgv7932n71	CNV	Loss	21882294
nsv516210	CNV	Loss	19592680
nsv891739	CNV	Loss	21882294
dgv7936n71	CNV	Loss	21882294
nsv891734	CNV	Loss	21882294
dgv7928n71	CNV	Loss	21882294
dgv7934n71	CNV	Loss	21882294
dgv7933n71	CNV	Loss	21882294

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TIGD5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TIGD5)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84948	HGNC: 18336	AceView: TIGD5	Ensembl:ENSG00000179886	euGenes: HUgn84948
ECgene: TIGD5	H-InvDB: TIGD5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TIGD5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TIGD5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TIGD5 gene:
Search GeneIP for patents involving TIGD5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for TIGD5
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	OriGene Custom Mass Spec		OriGene clones in human, mouse for TIGD5
	OriGene qSTAR qPCR primer pairs in human, mouse for TIGD5		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for TIGD5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIGD5
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	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIGD5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGD5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIGD5

	GenScript Custom Purified and Recombinant Proteins Services for TIGD5		GenScript cDNA clones with any tag delivered in your preferred vector for TIGD5
	GenScript Custom Assay Services for TIGD5		GenScript Custom Superior Antibodies Services for TIGD5
	GenScript Custom overexpressing Cell Line Services for TIGD5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD5

	SwitchGear 3'UTR luciferase reporter plasmids for TIGD5
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ThermoFisher Antibodies for TIGD5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD5

	inGenious Targeting Laboratory - Custom generated mouse model solutions for TIGD5
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TIGD5

Customized:

	lentivirus for stable overexpression of TIGD5
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LSBio Antibodies in human, mouse, rat for TIGD5

Customized transgenic rodents for:

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TIGD5 gene at Home site.

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TIGD5 Gene

Tigger Transposable Element Derived 5

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TIGD5 Gene

Tigger Transposable Element Derived 5

Aliasesfor TIGD5 gene

Summariesfor TIGD5 gene

Genomic Viewsfor TIGD5 gene

Proteinsfor TIGD5 gene

Protein Domains /Familiesfor TIGD5 gene

Functionfor TIGD5 gene

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