Aliases for TIGD5 Gene
External Ids for TIGD5 Gene
- HGNC: 18336
- Entrez Gene: 84948
- Ensembl: ENSG00000179886
- UniProtKB: Q53EQ6
Previous GeneCards Identifiers for TIGD5 Gene
- GC08P142725
- GC08P144908
- GC08P144454
- GC08P144785
- GC08P144751
- GC08P144680
- GC08P139914
Summaries for TIGD5 Gene
-
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIGD5 Gene
TIGD5 (Tigger Transposable Element Derived 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD5 Gene
Genomics for TIGD5 Gene
Regulatory Elements for TIGD5 Gene
Enhancers for TIGD5 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TIGD5 on UCSC Golden Path with GeneCards custom track
Promoters for TIGD5 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TIGD5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TIGD5 Gene
- Chromosome:
- 8
- Start:
- 143,597,835 bp from pter
- End:
- 143,603,224 bp from pter
- Size:
- 5,390 bases
- Orientation:
- Plus strand
Genomic View for TIGD5 Gene
Genes around TIGD5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
TIGD5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIGD5 Gene
Proteins for TIGD5 Gene
-
Protein details for TIGD5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q53EQ6-TIGD5_HUMAN
- Recommended name:
- Tigger transposable element-derived protein 5
- Protein Accession:
- Q53EQ6
- E7EWS2
- Q6NT83
- Q8N5A1
- Q96JW8
Protein attributes for TIGD5 Gene
- Size:
- 642 amino acids
- Molecular mass:
- 69222 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH32632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for TIGD5 Gene
Post-translational modifications for TIGD5 Gene
Other Protein References for TIGD5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TIGD5
- antibodies-online Antibodies for TIGD5: See all 7
- Search GeneTex for Antibodies for TIGD5
-
Santa Cruz Biotechnology (SCBT) Antibodies for TIGD5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TIGD5
- Origene Custom Protein Services for TIGD5
- antibodies-online Proteins for TIGD5: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TIGD5
Assay Products
No data available for DME Specific Peptides for TIGD5 Gene
Domains & Families for TIGD5 Gene
Gene Families for TIGD5 Gene
Protein Domains for TIGD5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIGD5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q53EQ6UniProtKB/Swiss-Prot:
TIGD5_HUMAN :- Contains 2 DDE domains.
- Belongs to the tigger transposable element derived protein family.
- Domain:
-
- Contains 2 DDE domains.
- Contains 1 HTH CENPB-type DNA-binding domain.
- Contains 1 HTH psq-type DNA-binding domain.
- Family:
-
- Belongs to the tigger transposable element derived protein family.
Function for TIGD5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for TIGD5 Gene
- GenomeRNAi human phenotypes for TIGD5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TIGD5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
- Search ViGene Biosciences for TIGD5
CRISPR Products
-
OriGene CRISPR knockouts for TIGD5
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIGD5
- GenScript: Design CRISPR guide RNA sequences for TIGD5
miRNA for TIGD5 Gene
- miRTarBase miRNAs that target TIGD5
-
- hsa-mir-7111-5p (MIRT486369)
- hsa-mir-6870-5p (MIRT486370)
- hsa-mir-5698 (MIRT486371)
- hsa-mir-4723-5p (MIRT486372)
- hsa-mir-6883-5p (MIRT486373)
- hsa-mir-6825-5p (MIRT486374)
- hsa-mir-6785-5p (MIRT486375)
- hsa-mir-4728-5p (MIRT486376)
- hsa-mir-149-3p (MIRT486377)
- hsa-mir-7106-5p (MIRT486378)
- hsa-mir-765 (MIRT486379)
- hsa-mir-4306 (MIRT486380)
- hsa-mir-4644 (MIRT486381)
- hsa-mir-185-5p (MIRT486382)
- hsa-mir-4784 (MIRT486383)
- hsa-mir-3150b-3p (MIRT486384)
- hsa-mir-1273f (MIRT486385)
- hsa-mir-6764-5p (MIRT486386)
- hsa-mir-6798-5p (MIRT486387)
- hsa-mir-1915-3p (MIRT486388)
- hsa-mir-6871-5p (MIRT486389)
- hsa-mir-6794-5p (MIRT486390)
- hsa-mir-4716-3p (MIRT486391)
- hsa-mir-4659b-3p (MIRT707841)
- hsa-mir-4659a-3p (MIRT707842)
- hsa-mir-6875-3p (MIRT707843)
- hsa-mir-3924 (MIRT707844)
- hsa-mir-190a-3p (MIRT707845)
- hsa-mir-5011-5p (MIRT707846)
- hsa-mir-5580-3p (MIRT707847)
miRNA Products
- Search ViGene Biosciences for TIGD5
Clone Products
- OriGene clones in human for TIGD5
- OriGene ORF clones in human,mouse,rat for TIGD5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TIGD5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TIGD5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD5 Gene
Localization for TIGD5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIGD5 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
No data available for Gene Ontology (GO) - Cellular Components for TIGD5 Gene
Pathways & Interactions for TIGD5 Gene
More details on SuperPathways for TIGD5
No Data Available
Interacting Proteins for TIGD5 Gene
Selected Interacting proteins:
ENSP00000421489
Q53EQ6-TIGD5_HUMAN
for TIGD5 Gene via
STRING
UniProtKB
No data available for Pathways by source and SIGNOR curated interactions for TIGD5 Gene
Transcripts for TIGD5 Gene
mRNA/cDNA for TIGD5 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (43) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TIGD5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TIGD5
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIGD5
- GenScript: Design CRISPR guide RNA sequences for TIGD5
miRNA Products
- Search ViGene Biosciences for TIGD5
Clone Products
- OriGene clones in human for TIGD5
- OriGene ORF clones in human,mouse,rat for TIGD5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for TIGD5 Gene
This gene is overexpressed in Kidney (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIGD5 Gene
SOURCE GeneReport for Unigene cluster for TIGD5 Gene Hs.71574
Primer Products
-
OriGene qPCR primer pairs for TIGD5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIGD5 Gene
Orthologs for TIGD5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TIGD5 35 |
|
||
| TIGD5 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TIGD5 35 |
|
||
| TIGD5 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Tigd5 35 |
|
||
| Tigd5 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Tigd5 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TIGD5 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TIGD5 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TIGD5 35 |
|
||
| TIGD5 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tigd5 35 |
|
- Species with no ortholog for TIGD5:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TIGD5 Gene
(1) SIMAP similar genes for TIGD5 Gene using alignment to 1 proteins:
Variants for TIGD5 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_030043 | - | ||||
| rs3210186 | -- | 143,600,141(+) | CCGTG(C/G)GGCTG | utr-variant-3-prime | |
| rs6558375 | -- | 143,600,578(+) | GCCAA(C/T)GGCAG | downstream-variant-500B | |
| rs111956838 | -- | 143,599,834(+) | GTGAC(C/T)AGGCC | utr-variant-3-prime | |
| rs143174212 | -- | 143,600,188(+) | AGGGC(C/T)GAAAC | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv470247 | CNV | Loss | 18288195 |
| nsv891676 | CNV | Loss | 21882294 |
| dgv7928n71 | CNV | Loss | 21882294 |
| dgv7932n71 | CNV | Loss | 21882294 |
| dgv7933n71 | CNV | Loss | 21882294 |
| dgv7934n71 | CNV | Loss | 21882294 |
| nsv516210 | CNV | Loss | 19592680 |
| dgv7935n71 | CNV | Loss | 21882294 |
| dgv7936n71 | CNV | Loss | 21882294 |
| dgv7937n71 | CNV | Loss | 21882294 |
| nsv891734 | CNV | Loss | 21882294 |
| nsv891737 | CNV | Gain | 21882294 |
| nsv466004 | CNV | Loss | 19166990 |
| nsv891739 | CNV | Loss | 21882294 |
| nsv831488 | CNV | Loss | 17160897 |
| nsv824771 | CNV | Gain | 20364138 |
| esv26007 | CNV | Loss | 19812545 |
Gene Damage Index Score:
1.92;
35.76% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TIGD5 Gene
Disorders for TIGD5 Gene
Relevant External Links for TIGD5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TIGD5
No disorders were found for TIGD5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD5 Gene
Publications for TIGD5 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
Products for TIGD5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for TIGD5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TIGD5
- Origene Custom Protein Services for TIGD5
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for TIGD5
- Browse OriGene Inhibitory RNA Products For TIGD5
- OriGene qPCR primer pairs for TIGD5
- OriGene CRISPR knockouts for TIGD5
- OriGene clones in human for TIGD5
- OriGene ORF clones in human,mouse,rat for TIGD5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TIGD5
- GenScript Custom Assay Services for TIGD5
- GenScript Custom overexpressing Cell Line Services for TIGD5
- GenScript: Design CRISPR guide RNA sequences for TIGD5
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- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
- GenScript Custom Peptide Services for TIGD5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for TIGD5: See all 7
- Search antibodies-online for kits
- antibodies-online Proteins for TIGD5: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for TIGD5
- Search GeneTex for Proteins for TIGD5
- ViGene Biosciences adenoviral particle packaged cDNA for TIGD5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TIGD5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TIGD5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TIGD5 gene
- Search ViGene Biosciences for TIGD5
- Search ViGene Biosciences for TIGD5
- Santa Cruz Biotechnology (SCBT) Antibodies for TIGD5
- Search Santa Cruz Biotechnology (SCBT) for TIGD5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TIGD5
Sources for TIGD5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon