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Aliases for TIGD4 Gene

Aliases for TIGD4 Gene

  • Tigger Transposable Element Derived 4 2 3 5

External Ids for TIGD4 Gene

Previous GeneCards Identifiers for TIGD4 Gene

  • GC04M154542
  • GC04M154079
  • GC04M154268
  • GC04M154048
  • GC04M153909
  • GC04M153690
  • GC04M149416

Summaries for TIGD4 Gene

Entrez Gene Summary for TIGD4 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD4 Gene

TIGD4 (Tigger Transposable Element Derived 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is TIGD5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD4 Gene

Genomics for TIGD4 Gene

Regulatory Elements for TIGD4 Gene

Promoters for TIGD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIGD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIGD4 Gene

Chromosome:
4
Start:
152,769,354 bp from pter
End:
152,779,789 bp from pter
Size:
10,436 bases
Orientation:
Minus strand

Genomic View for TIGD4 Gene

Genes around TIGD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD4 Gene

Proteins for TIGD4 Gene

  • Protein details for TIGD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY51-TIGD4_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 4
    Protein Accession:
    Q8IY51
    Secondary Accessions:
    • Q96LP5

    Protein attributes for TIGD4 Gene

    Size:
    512 amino acids
    Molecular mass:
    57468 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71642.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TIGD4 Gene

Proteomics data for TIGD4 Gene at MOPED

Post-translational modifications for TIGD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD4 Gene

Domains & Families for TIGD4 Gene

Gene Families for TIGD4 Gene

Suggested Antigen Peptide Sequences for TIGD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY51

UniProtKB/Swiss-Prot:

TIGD4_HUMAN :
  • Contains 1 DDE domain.
  • Belongs to the tigger transposable element derived protein family.
Domain:
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD4: view

Function for TIGD4 Gene

genes like me logo Genes that share phenotypes with TIGD4: view

Animal Model Products

miRNA for TIGD4 Gene

miRTarBase miRNAs that target TIGD4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD4 Gene

Localization for TIGD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIGD4 Gene COMPARTMENTS Subcellular localization image for TIGD4 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TIGD4 Gene

Pathways & Interactions for TIGD4 Gene

SuperPathways for TIGD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIGD4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD4 Gene

Drugs & Compounds for TIGD4 Gene

No Compound Related Data Available

Transcripts for TIGD4 Gene

mRNA/cDNA for TIGD4 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD4 Gene

Tigger transposable element derived 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD4 Gene

No ASD Table

Relevant External Links for TIGD4 Gene

GeneLoc Exon Structure for
TIGD4
ECgene alternative splicing isoforms for
TIGD4

Expression for TIGD4 Gene

mRNA expression in normal human tissues for TIGD4 Gene

mRNA differential expression in normal tissues according to GTEx for TIGD4 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for TIGD4 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGD4 Gene



SOURCE GeneReport for Unigene cluster for TIGD4 Gene Hs.301243

genes like me logo Genes that share expression patterns with TIGD4: view

Protein tissue co-expression partners for TIGD4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TIGD4 Gene

Orthologs for TIGD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIGD4 35
  • 99.48 (n)
  • 99.02 (a)
TIGD4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIGD4 36
  • 90 (a)
OneToOne
TIGD4 35
  • 89.65 (n)
  • 90.23 (a)
dog
(Canis familiaris)
Mammalia TIGD4 35
  • 91.83 (n)
  • 91.57 (a)
TIGD4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tigd4 16
Tigd4 36
  • 85 (a)
OneToOne
Tigd4 35
  • 84.11 (n)
  • 85.16 (a)
oppossum
(Monodelphis domestica)
Mammalia TIGD4 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102550932 35
  • 84.24 (n)
  • 84.77 (a)
lizard
(Anolis carolinensis)
Reptilia TIGD4 36
  • 65 (a)
OneToOne
Species with no ortholog for TIGD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD4 Gene

ENSEMBL:
Gene Tree for TIGD4 (if available)
TreeFam:
Gene Tree for TIGD4 (if available)

Paralogs for TIGD4 Gene

Paralogs for TIGD4 Gene

(1) SIMAP similar genes for TIGD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD4: view

Variants for TIGD4 Gene

Sequence variations from dbSNP and Humsavar for TIGD4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4696354 - 152,769,690(+) GCATA(C/G/T)GGAAT reference, missense
rs34432931 - 152,769,711(-) GTGAA(A/G)CAGCA reference, missense
rs35581576 - 152,769,539(-) AAGTC(A/G)AGATA reference, missense
rs4276265 -- 152,774,627(+) CTAAT(C/T)AGAAA intron-variant, upstream-variant-2KB
rs6850467 -- 152,775,483(+) ccagg(C/T)gcaat intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TIGD4 Gene

Variant ID Type Subtype PubMed ID
nsv522511 CNV Loss 19592680
nsv516652 CNV Loss 19592680

Variation tolerance for TIGD4 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGD4 Gene

HapMap Linkage Disequilibrium report
TIGD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD4 Gene

Disorders for TIGD4 Gene

Relevant External Links for TIGD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIGD4

No disorders were found for TIGD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD4 Gene

Publications for TIGD4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TIGD4 Gene

Sources for TIGD4 Gene

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