Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIGD4 Gene

Aliases for TIGD4 Gene

  • Tigger Transposable Element Derived 4 2 3

External Ids for TIGD4 Gene

Previous GeneCards Identifiers for TIGD4 Gene

  • GC04M154542
  • GC04M154079
  • GC04M154268
  • GC04M154048
  • GC04M153909
  • GC04M153690
  • GC04M149416

Summaries for TIGD4 Gene

Entrez Gene Summary for TIGD4 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD4 Gene

TIGD4 (Tigger Transposable Element Derived 4) is a Protein Coding gene. An important paralog of this gene is TIGD5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD4 Gene

Genomics for TIGD4 Gene

Regulatory Elements for TIGD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIGD4 Gene

152,768,685 bp from pter
152,779,764 bp from pter
11,080 bases
Minus strand

Genomic View for TIGD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIGD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD4 Gene

Proteins for TIGD4 Gene

  • Protein details for TIGD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 4
    Protein Accession:
    Secondary Accessions:
    • Q96LP5

    Protein attributes for TIGD4 Gene

    512 amino acids
    Molecular mass:
    57468 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71642.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TIGD4 Gene

Proteomics data for TIGD4 Gene at MOPED

Post-translational modifications for TIGD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TIGD4 Gene

Domains for TIGD4 Gene

Suggested Antigen Peptide Sequences for TIGD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IY51
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD4: view

No data available for Gene Families for TIGD4 Gene

Function for TIGD4 Gene

Gene Ontology (GO) - Molecular Function for TIGD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding --
genes like me logo Genes that share ontologies with TIGD4: view

Phenotypes for TIGD4 Gene

GenomeRNAi human phenotypes for TIGD4:
genes like me logo Genes that share phenotypes with TIGD4: view

Animal Model Products

miRNA for TIGD4 Gene

miRTarBase miRNAs that target TIGD4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIGD4 Gene

Localization for TIGD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD4 Gene

Subcellular locations from

Jensen Localization Image for TIGD4 Gene COMPARTMENTS Subcellular localization image for TIGD4 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TIGD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD4: view

Pathways for TIGD4 Gene

SuperPathways for TIGD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIGD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with TIGD4: view

No data available for Pathways by source for TIGD4 Gene

Transcripts for TIGD4 Gene

mRNA/cDNA for TIGD4 Gene

(15) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD4 Gene

Tigger transposable element derived 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD4 Gene

No ASD Table

Relevant External Links for TIGD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD4 Gene

mRNA expression in normal human tissues for TIGD4 Gene

mRNA differential expression in normal tissues according to GTEx for TIGD4 Gene

This gene is overexpressed in Testis (8.8).

Protein differential expression in normal tissues for TIGD4 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIGD4 Gene

SOURCE GeneReport for Unigene cluster for TIGD4 Gene Hs.301243

genes like me logo Genes that share expressions with TIGD4: view

Expression partners for TIGD4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TIGD4 Gene

Orthologs for TIGD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIGD4 35
  • 89.65 (n)
  • 90.23 (a)
TIGD4 36
  • 90 (a)
(Canis familiaris)
Mammalia TIGD4 35
  • 91.83 (n)
  • 91.57 (a)
TIGD4 36
  • 91 (a)
(Mus musculus)
Mammalia Tigd4 35
  • 84.11 (n)
  • 85.16 (a)
Tigd4 16
Tigd4 36
  • 85 (a)
(Pan troglodytes)
Mammalia TIGD4 35
  • 99.48 (n)
  • 99.02 (a)
TIGD4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC102550932 35
  • 84.24 (n)
  • 84.77 (a)
(Monodelphis domestica)
Mammalia TIGD4 36
  • 78 (a)
(Anolis carolinensis)
Reptilia TIGD4 36
  • 65 (a)
Species with no ortholog for TIGD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD4 Gene

Gene Tree for TIGD4 (if available)
Gene Tree for TIGD4 (if available)

Paralogs for TIGD4 Gene

Paralogs for TIGD4 Gene

Selected SIMAP similar genes for TIGD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD4: view

Variants for TIGD4 Gene

Sequence variations from dbSNP and Humsavar for TIGD4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4276265 -- 152,774,627(+) CTAAT(C/T)AGAAA intron-variant
rs4359882 -- 152,773,783(+) TAACA(A/T)TAAAA intron-variant, upstream-variant-2KB
rs4359883 -- 152,773,961(+) TACTA(A/T)GAGAA intron-variant
rs4359884 -- 152,774,349(+) AAAAA(C/T)AATCA intron-variant
rs4696353 -- 152,768,545(+) AAGTG(A/C/T)TACCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TIGD4 Gene

Variant ID Type Subtype PubMed ID
nsv522511 CNV Loss 19592680
nsv516652 CNV Loss 19592680

Relevant External Links for TIGD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD4 Gene

Disorders for TIGD4 Gene

No disorders were found for TIGD4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TIGD4 Gene

Publications for TIGD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for TIGD4 Gene

Sources for TIGD4 Gene

Back to Top