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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIGD4 Gene

protein-coding   GIFtS: 43
GCID: GC04M153690

tigger transposable element derived 4
  Search for TIGD4
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TIGD4    

Aliases
for TIGD4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tigger Transposable Element Derived 41 2
Tigger Transposable Element-Derived Protein 42

External Ids:    HGNC: 183351   Entrez Gene: 2017982   Ensembl: ENSG000001699897   UniProtKB: Q8IY513   

Export aliases for TIGD4 gene to outside databases

Previous GC identifers: GC04M154542 GC04M154079 GC04M154268 GC04M154048 GC04M153909 GC04M149416


Summaries
for TIGD4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TIGD4:
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in
humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and
mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of
this gene is not known. (provided by RefSeq, Jul 2008)




Genomic Views
for TIGD4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIGD4 gene promoter:
         STAT1   ISGF-3   PPAR-alpha   MEF-2A   AREB6   PPAR-gamma1   HSF2   Chx10   aMEF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIGD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIGD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.23

TIGD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIGD4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M153690:  view genomic region     (about GC identifiers)

Start:
 153,690,506 bp from pter      End:
 153,700,916 bp from pter
Size:
 10,411 bases      Orientation:
 minus strand

Proteins
for TIGD4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TIGD4_HUMAN, Q8IY51 (See protein sequence)
Recommended Name: Tigger transposable element-derived protein 4  
Size: 512 amino acids; 57468 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB71642.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96LP5

Explore the universe of human proteins at neXtProt for TIGD4: NX_Q8IY51

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IY51

    • TIGD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_663772.1  
    ENSEMBL proteins: 
     ENSP00000355162  

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    Uscn Proteins for TIGD4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TIGD4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TIGD4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TIGD4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006600 HTH_CenpB_DNA-bd_dom
     IPR004875 DDE_SF_endonuclease_CENPB-like
     IPR009057 Homeodomain-like
     IPR007889 HTH_Psq

    Graphical View of Domain Structure for InterPro Entry Q8IY51

    ProtoNet protein and cluster: Q8IY51

    2 Blocks protein families:
    IPB004875 CENP-B protein
    IPB006695 CENP-B


    UniProtKB/Swiss-Prot: TIGD4_HUMAN, Q8IY51
    Similarity: Belongs to the tigger transposable element derived protein family
    Similarity: Contains 1 DDE domain
    Similarity: Contains 1 HTH CENPB-type DNA-binding domain
    Similarity: Contains 1 HTH psq-type DNA-binding domain


    Function
    for TIGD4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--


    TIGD4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TIGD4:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for TIGD4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIGD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TIGD4 (Q8IY513 ENSP000003551624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXD4P090163, ENSP000003025484I2D: score=1 STRING: ENSP00000302548
    About this table

    Drugs & Compounds
    for TIGD4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIGD4
    Search CenterWatch for drugs/clinical trials and news about TIGD4 

    Transcripts
    for TIGD4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TIGD4 gene: 
    NM_145720.3  

    Unigene Cluster for TIGD4:

    Tigger transposable element derived 4
    Hs.301243  [show with all ESTs]
    Unigene Representative Sequence: AK024235
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304337(uc003imy.3)

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK024235.1 AK058054.1 BC037869.2 

    3 DOTS entries:

    DT.40196986  DT.91916452  DT.97830993 

    15 AceView cDNA sequences:

    BE218430 AK058054 BC037869 NM_145720 BX954732 AA758641 BI827730 BX954595 
    BG720707 BX109512 AI566011 BP368839 BG538792 BX490787 BX499808 

    GeneLoc Exon Structure


    Expression
    for TIGD4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIGD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TIGD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Beating cell clusters (Spontaneous differen...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TIGD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIGD4

    SOURCE GeneReport for Unigene cluster: Hs.301243
        SABiosciences Custom PCR Arrays for TIGD4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD4

    Orthologs
    for TIGD4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TIGD4 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia TIGD46
    		 --
    		 63(a)
    		 1 ↔ 1
    		 5(131497661-131498788)


    ENSEMBL Gene Tree for TIGD4 (if available)
    TreeFam Gene Tree for TIGD4 (if available) 

    Paralogs
    for TIGD4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIGD4 gene
    TIGD12  TIGD22  CENPB2  TIGD62  TIGD72  JRKL2  TIGD52  TIGD32  
    1 SIMAP similar gene for TIGD4 using alignment to 1 protein entry:     TIGD4_HUMAN:
    TIGD6

    TIGD4 for paralogs           About GeneDecksing



    Genomic Variants
    for TIGD4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TIGD4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TIGD4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIGD4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TIGD4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for TIGD4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TIGD4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201798 HGNC: 18335 AceView: TIGD4 Ensembl:ENSG00000169989 euGenes: HUgn201798
    ECgene: TIGD4 H-InvDB: TIGD4

    Other Databases showing TIGD4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TIGD4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIGD4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TIGD4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TIGD4 gene:
    Search GeneIP for patents involving TIGD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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