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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIGD3 Gene

protein-coding GIFtS: 43
GCID: GC11P065122

tigger transposable element derived 3

Search for TIGD3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tigger Transposable Element Derived 3¹ ²
Tigger Transposable Element-Derived Protein 3²

External Ids:	HGNC: 18334¹	Entrez Gene: 220359²	Ensembl: ENSG00000173825⁷	UniProtKB: Q6B0B8³

Export aliases for TIGD3 gene to outside databases

Previous GC identifers: GC11P067639 GC11P066803 GC11P065372 GC11P064897 GC11P064878 GC11P061449

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIGD3:

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in

humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and

mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of

this gene is not known. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIGD3 gene promoter:
FOXF2 LCR-F1 Meis-1b RORalpha2 C/EBPalpha Egr-2 HOXA5 SEF-1 (1) Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIGD3 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1

TIGD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIGD3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065122: view genomic region (about GC identifiers)

Start:	65,122,238 bp from pter	End:	65,125,084 bp from pter
Size:	2,847 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIGD3_HUMAN, Q6B0B8 (See protein sequence)

Recommended Name: Tigger transposable element-derived protein 3

Size: 471 amino acids; 52027 Da

Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for TIGD3: NX_Q6B0B8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6B0B8

TIGD3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_663771.1

ENSEMBL proteins:

ENSP00000308354

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TIGD3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIGD3 for domains About GeneDecksing

4 InterPro domains/families:

IPR006600 HTH_CenpB_DNA-bd_dom

IPR004875 DDE_SF_endonuclease_CENPB-like

IPR009057 Homeodomain-like

IPR007889 HTH_Psq

Graphical View of Domain Structure for InterPro Entry Q6B0B8

ProtoNet protein and cluster: Q6B0B8

1 Blocks protein family: IPB004875 CENP-B protein

UniProtKB/Swiss-Prot: TIGD3_HUMAN, Q6B0B8

Similarity: Belongs to the tigger transposable element derived protein family

Similarity: Contains 1 DDE domain

Similarity: Contains 1 HTH CENPB-type DNA-binding domain

Similarity: Contains 1 HTH psq-type DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

TIGD3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TIGD3:

Decreased POU5F1-GFP protein e

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TIGD3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TIGD3 gene:

NM_145719.2

Unigene Cluster for TIGD3:

Tigger transposable element derived 3

Hs.632121 [show with all ESTs]

Unigene Representative Sequence: NM_145719

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000309880(uc001odo.4)

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Additional cDNA sequence:

AF001546.1 BC074862.2

1 DOTS entry:

DT.442121

24/28 AceView cDNA sequences (see all 28):

AI800805 NM_145719 AI221324 BM988096 CR599655 BC074862 AI863063 BM679909

AI283490 AI243383 AA952902 AI769014 BU630785 F10384 AI660235 BU741546

BX350318 AL558462 AI028111 BV184098 F12776 AL580283 BM728260 N76165

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIGD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAACGGCCT

About this image

TIGD3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See TIGD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIGD3

SOURCE GeneReport for Unigene cluster: Hs.632121

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TIGD3 gene from 1/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	TIGD3⁶	--	29(a)	1 ↔ 1	GL343620.1(164351-165742)

ENSEMBL Gene Tree for TIGD3 (if available)
TreeFam Gene Tree for TIGD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TIGD3 gene

TIGD2² JRKL² TIGD1² TIGD7² TIGD5² CENPB² TIGD6² TIGD4²

TIGD3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74809589^1,2	F,	--	65121078(+)	`CTTACG/ATGGCA`	1	--	us2k¹		1		WA	118
rs658794^1,2	C,F,A,H,	--	65121203(+)	`ATTCTG/TAAAGT`	1	--	us2k¹		6		NS NA	478
rs138796491^1,2		--	65121264(+)	`AATAAA/GCAGGG`	1	--	us2k¹		0	--	--	--	--
rs187939378^1,2		--	65121406(+)	`AAGAAA/GTGTGG`	1	--	us2k¹		0	--	--	--	--
rs191979795^1,2		--	65121517(+)	`GGTAGG/TACGGG`	1	--	us2k¹		0	--	--	--	--
rs112866560^1,2		--	65121524(+)	`CGGGGG/TTGCGG`	1	--	us2k¹		2		CSA WA	120
rs73482268^1,2	C,F,	--	65121780(+)	`CGAGCC/TAGCGC`	1	--	us2k¹		3		WA CSA	122
rs148462787^1,2		--	65122080(+)	`CCCCC-/AGAGGGG CTCGACGAACCGCC`	1	--	us2k¹		0	--	--	--	--
rs12790028^1,2	C	--	65122165(+)	`ATCTGC/TTTGGG`	1	--	us2k¹		1		NA	2
rs1018853^1,2	C,	--	65122682(+)	`GCCCTG/CCCCTC`	1	--	int¹		5		NA WA EA	362

HapMap Linkage Disequilibrium report for TIGD3 (65122238 - 65125084 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TIGD3
1 CNV: 5423

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TIGD3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TIGD3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Putative CENP-B paralogues are not present at mammalia n centromeres. (PubMed id 22080934)¹ Marshall O.J. and Choo K.H. (2012)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 220359	HGNC: 18334	AceView: TIGD3	Ensembl:ENSG00000173825	euGenes: HUgn220359
ECgene: TIGD3	H-InvDB: TIGD3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TIGD3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TIGD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TIGD3 gene:
Search GeneIP for patents involving TIGD3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD3

	SwitchGear 3'UTR luciferase reporter plasmids for TIGD3
	SwitchGear Promoter luciferase reporter plasmids for TIGD3

ThermoFisher Antibodies for TIGD3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TIGD3 gene at Home site.

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TIGD3 Gene

tigger transposable element derived 3

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TIGD3 Gene

tigger transposable element derived 3

Aliasesfor TIGD3 gene

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Genomic Viewsfor TIGD3 gene

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External Searches for TIGD3 gene

Genome Databases showing TIGD3 gene

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Specialized Databases showing TIGD3 gene

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for TIGD3 gene

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for TIGD3 gene

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for TIGD3 gene

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for TIGD3 gene

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for TIGD3 gene

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for TIGD3 gene

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for TIGD3 gene

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