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Aliases for TIGD3 Gene

Aliases for TIGD3 Gene

  • Tigger Transposable Element Derived 3 2 3 5

External Ids for TIGD3 Gene

Previous GeneCards Identifiers for TIGD3 Gene

  • GC11P067639
  • GC11P066803
  • GC11P065372
  • GC11P064897
  • GC11P064878
  • GC11P065122
  • GC11P061449

Summaries for TIGD3 Gene

Entrez Gene Summary for TIGD3 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD3 Gene

TIGD3 (Tigger Transposable Element Derived 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD3 Gene

Genomics for TIGD3 Gene

Regulatory Elements for TIGD3 Gene

Enhancers for TIGD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065567 1 FANTOM5 ENCODE 13.3 +218.9 218908 12.0 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC NEAT1 MRPL11 KCNK7 CD248 EHBP1L1 TIGD3 MAP3K11 CTSW PCNX3 CDC42EP2
GH11F065375 0.8 ENCODE 12.7 +20.5 20458 0.2 ZNF316 TIGD3 MIR612 CDC42EP2 ENSG00000255478 SLC25A45
GH11F065400 0.6 ENCODE 11.4 +46.7 46661 2.4 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A ARID4B ZNF48 JUNB NCOA1 NEAT1 ENSG00000255478 MIR612 TIGD3 LOC728975 BANF1 FRMD8 GC11P065418
GH11F065438 1 ENCODE 11.2 +89.5 89464 10.7 PKNOX1 SIN3A YY1 ZNF121 GLIS2 ZNF207 PAF1 ZNF263 TBX21 SSRP1 NEAT1 FRMD8 SLC25A45 MALAT1 ENSG00000255478 TIGD3 CDC42EP2 LOC101927789 LOC728975 BANF1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TIGD3 on UCSC Golden Path with GeneCards custom track

Promoters for TIGD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TIGD3 Gene

65,354,767 bp from pter
65,357,613 bp from pter
2,847 bases
Plus strand

Genomic View for TIGD3 Gene

Genes around TIGD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD3 Gene

Proteins for TIGD3 Gene

  • Protein details for TIGD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 3
    Protein Accession:

    Protein attributes for TIGD3 Gene

    471 amino acids
    Molecular mass:
    52027 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD3 Gene

Post-translational modifications for TIGD3 Gene

No Post-translational modifications

Other Protein References for TIGD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD3 Gene

Domains & Families for TIGD3 Gene

Gene Families for TIGD3 Gene

Protein Domains for TIGD3 Gene

Suggested Antigen Peptide Sequences for TIGD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DDE-1 domain.
  • Belongs to the tigger transposable element derived protein family.
  • Contains 1 DDE-1 domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD3: view

Function for TIGD3 Gene

Gene Ontology (GO) - Molecular Function for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD3: view
genes like me logo Genes that share phenotypes with TIGD3: view

Animal Model Products

miRNA for TIGD3 Gene

miRTarBase miRNAs that target TIGD3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD3 Gene

Localization for TIGD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD3 Gene

Subcellular locations from

Jensen Localization Image for TIGD3 Gene COMPARTMENTS Subcellular localization image for TIGD3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD3: view

Pathways & Interactions for TIGD3 Gene

SuperPathways for TIGD3 Gene

No Data Available

Interacting Proteins for TIGD3 Gene

Gene Ontology (GO) - Biological Process for TIGD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD3 Gene

Transcripts for TIGD3 Gene

mRNA/cDNA for TIGD3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD3 Gene

Tigger transposable element derived 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD3 Gene

No ASD Table

Relevant External Links for TIGD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIGD3 Gene

mRNA differential expression in normal tissues according to GTEx for TIGD3 Gene

This gene is overexpressed in Whole Blood (x7.2), Testis (x5.8), Brain - Cerebellum (x5.1), and Brain - Cerebellar Hemisphere (x4.9).

Protein differential expression in normal tissues from HIPED for TIGD3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGD3 Gene

Protein tissue co-expression partners for TIGD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIGD3 Gene:


SOURCE GeneReport for Unigene cluster for TIGD3 Gene:

genes like me logo Genes that share expression patterns with TIGD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TIGD3 Gene

Orthologs for TIGD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIGD3 34 35
  • 99.58 (n)
(Canis familiaris)
Mammalia TIGD3 34 35
  • 87.33 (n)
(Bos Taurus)
Mammalia TIGD3 34 35
  • 87.05 (n)
(Mus musculus)
Mammalia Tigd3 34 16 35
  • 83.12 (n)
(Rattus norvegicus)
Mammalia Tigd3 34
  • 82.41 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 20 (a)
(Gallus gallus)
Aves TIGD3 35
  • 34 (a)
(Anolis carolinensis)
Reptilia TIGD3 35
  • 24 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tigd3 34
  • 45.28 (n)
Species where no ortholog for TIGD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD3 Gene

Gene Tree for TIGD3 (if available)
Gene Tree for TIGD3 (if available)

Paralogs for TIGD3 Gene

Paralogs for TIGD3 Gene

genes like me logo Genes that share paralogs with TIGD3: view

Variants for TIGD3 Gene

Sequence variations from dbSNP and Humsavar for TIGD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1018853 -- 65,355,211(+) GCCCT(C/G)CCCTC intron-variant
rs111844146 -- 65,353,476(+) TGCCT(G/T)CAGCG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs11227182 -- 65,353,640(+) TTTTA(A/G)AAGTC upstream-variant-2KB, utr-variant-3-prime
rs112411807 -- 65,357,437(+) GGTAG(G/T)AATCC utr-variant-3-prime
rs112866560 -- 65,354,053(+) CGGGG(G/T)TGCGG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIGD3 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv482159 CNV gain 20164927
nsv526181 CNV gain 19592680
nsv832190 CNV loss 17160897

Variation tolerance for TIGD3 Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD3 Gene

Disorders for TIGD3 Gene

Relevant External Links for TIGD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIGD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD3 Gene

Publications for TIGD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Putative CENP-B paralogues are not present at mammalian centromeres. (PMID: 22080934) Marshall O.J. … Choo K.H. (Chromosoma 2012) 3 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru S.C. … Chandrasekharappa S.C. (Genome Res. 1997) 3 64
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for TIGD3 Gene

Sources for TIGD3 Gene

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