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Aliases for TIGD3 Gene

Aliases for TIGD3 Gene

  • Tigger Transposable Element Derived 3 2 3

External Ids for TIGD3 Gene

Previous GeneCards Identifiers for TIGD3 Gene

  • GC11P067639
  • GC11P066803
  • GC11P065372
  • GC11P064897
  • GC11P064878
  • GC11P065122
  • GC11P061449

Summaries for TIGD3 Gene

Entrez Gene Summary for TIGD3 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD3 Gene

TIGD3 (Tigger Transposable Element Derived 3) is a Protein Coding gene. An important paralog of this gene is TIGD5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD3 Gene

Genomics for TIGD3 Gene

Regulatory Elements for TIGD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIGD3 Gene

65,354,767 bp from pter
65,357,613 bp from pter
2,847 bases
Plus strand

Genomic View for TIGD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIGD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD3 Gene

Proteins for TIGD3 Gene

  • Protein details for TIGD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TIGD3 Gene

    471 amino acids
    Molecular mass:
    52027 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD3 Gene

Proteomics data for TIGD3 Gene at MOPED

Post-translational modifications for TIGD3 Gene

No Post-translational modifications

Other Protein References for TIGD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD3 Gene

Domains for TIGD3 Gene

Protein Domains for TIGD3 Gene

Suggested Antigen Peptide Sequences for TIGD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6B0B8
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD3: view

No data available for Gene Families for TIGD3 Gene

Function for TIGD3 Gene

Gene Ontology (GO) - Molecular Function for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD3: view

Phenotypes for TIGD3 Gene

genes like me logo Genes that share phenotypes with TIGD3: view

Animal Model Products

miRNA for TIGD3 Gene

miRTarBase miRNAs that target TIGD3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIGD3 Gene

Localization for TIGD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD3 Gene

Subcellular locations from

Jensen Localization Image for TIGD3 Gene COMPARTMENTS Subcellular localization image for TIGD3 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD3: view

Pathways for TIGD3 Gene

SuperPathways for TIGD3 Gene

No Data Available

Interacting Proteins for TIGD3 Gene

Gene Ontology (GO) - Biological Process for TIGD3 Gene


No data available for Pathways by source for TIGD3 Gene

Transcripts for TIGD3 Gene

mRNA/cDNA for TIGD3 Gene

(28) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD3 Gene

Tigger transposable element derived 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD3 Gene

No ASD Table

Relevant External Links for TIGD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD3 Gene

mRNA expression in normal human tissues for TIGD3 Gene

mRNA differential expression in normal tissues according to GTEx for TIGD3 Gene

This gene is overexpressed in Whole Blood (7.2), Testis (5.8), Brain - Cerebellum (5.1), and Brain - Cerebellar Hemisphere (4.9).

Protein differential expression in normal tissues for TIGD3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIGD3 Gene

SOURCE GeneReport for Unigene cluster for TIGD3 Gene Hs.632121

genes like me logo Genes that share expressions with TIGD3: view

Expression partners for TIGD3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TIGD3 Gene

Orthologs for TIGD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIGD3 35
  • 87.05 (n)
  • 84.5 (a)
TIGD3 36
  • 85 (a)
(Canis familiaris)
Mammalia TIGD3 35
  • 87.33 (n)
  • 87.69 (a)
TIGD3 36
  • 88 (a)
(Mus musculus)
Mammalia Tigd3 35
  • 83.12 (n)
  • 83.62 (a)
Tigd3 16
Tigd3 36
  • 84 (a)
(Pan troglodytes)
Mammalia TIGD3 35
  • 99.58 (n)
  • 99.15 (a)
TIGD3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tigd3 35
  • 82.41 (n)
  • 82.98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 20 (a)
(Gallus gallus)
Aves TIGD3 36
  • 34 (a)
(Anolis carolinensis)
Reptilia TIGD3 36
  • 24 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tigd3 35
  • 45.28 (n)
  • 33.53 (a)
Species with no ortholog for TIGD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD3 Gene

Gene Tree for TIGD3 (if available)
Gene Tree for TIGD3 (if available)

Paralogs for TIGD3 Gene

Paralogs for TIGD3 Gene

genes like me logo Genes that share paralogs with TIGD3: view

Variants for TIGD3 Gene

Sequence variations from dbSNP and Humsavar for TIGD3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs612392 -- 65,355,775(+) CTCAA(G/T)CTTTC intron-variant
rs658794 -- 65,353,732(+) ATTCT(G/T)AAAGT upstream-variant-2KB
rs1018853 -- 65,355,211(+) GCCCT(C/G)CCCTC intron-variant
rs3741386 -- 65,357,521(-) CACCT(A/T)TCTAA utr-variant-3-prime
rs3832789 -- 65,357,599(-) TAAAA(-/A)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TIGD3 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
nsv832190 CNV Loss 17160897
esv2422285 CNV Deletion 17116639
dgv1175n71 CNV Loss 21882294
nsv482159 CNV Gain 20164927

Relevant External Links for TIGD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD3 Gene

Disorders for TIGD3 Gene

No disorders were found for TIGD3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TIGD3 Gene

Publications for TIGD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Putative CENP-B paralogues are not present at mammalian centromeres. (PMID: 22080934) Marshall O.J. … Choo K.H. (Chromosoma 2012) 3
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TIGD3 Gene

Sources for TIGD3 Gene

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