Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIGD2 Gene

Aliases for TIGD2 Gene

  • Tigger Transposable Element Derived 2 2 3
  • Tigger Transposable Element-Derived Protein 2 3
  • Epididymis Luminal Protein 106 3
  • HEL106 3

External Ids for TIGD2 Gene

Summaries for TIGD2 Gene

Entrez Gene Summary for TIGD2 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD2 Gene

TIGD2 (Tigger Transposable Element Derived 2) is a Protein Coding gene. Diseases associated with TIGD2 include intrahepatic cholangiocarcinoma. An important paralog of this gene is TIGD5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD2 Gene

Genomics for TIGD2 Gene

Genomic Location for TIGD2 Gene

89,112,817 bp from pter
89,114,901 bp from pter
2,085 bases
Plus strand

Genomic View for TIGD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIGD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD2 Gene

Regulatory Elements for TIGD2 Gene

Proteins for TIGD2 Gene

  • Protein details for TIGD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TIGD2 Gene

    525 amino acids
    Molecular mass:
    59623 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD2 Gene

Proteomics data for TIGD2 Gene at MOPED

Post-translational modifications for TIGD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD2 Gene

Domains for TIGD2 Gene


  • Contains 1 DDE domain.:
    • Q4W5G0
  • Contains 1 HTH CENPB-type DNA-binding domain.:
    • Q4W5G0
  • Contains 1 HTH psq-type DNA-binding domain.:
    • Q4W5G0
  • Belongs to the tigger transposable element derived protein family.:
    • Q4W5G0
genes like me logo Genes that share domains with TIGD2: view

No data available for Gene Families for TIGD2 Gene

Function for TIGD2 Gene

Gene Ontology (GO) - Molecular Function for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD2: view

Phenotypes for TIGD2 Gene

GenomeRNAi human phenotypes for TIGD2:
genes like me logo Genes that share phenotypes with TIGD2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TIGD2 Gene

Localization for TIGD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD2 Gene

Subcellular locations from

Jensen Localization Image for TIGD2 Gene COMPARTMENTS Subcellular localization image for TIGD2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD2: view

Pathways for TIGD2 Gene

SuperPathways for TIGD2 Gene

No Data Available

Interacting Proteins for TIGD2 Gene

Gene Ontology (GO) - Biological Process for TIGD2 Gene


No data available for Pathways by source for TIGD2 Gene

Transcripts for TIGD2 Gene

mRNA/cDNA for TIGD2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD2 Gene

Tigger transposable element derived 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD2 Gene

No ASD Table

Relevant External Links for TIGD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD2 Gene

mRNA expression in normal human tissues for TIGD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIGD2 Gene

This gene is overexpressed in Liver (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIGD2 Gene

SOURCE GeneReport for Unigene cluster for TIGD2 Gene Hs.58924

genes like me logo Genes that share expressions with TIGD2: view

Orthologs for TIGD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIGD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIGD2 36
  • 92.57 (n)
  • 94.29 (a)
TIGD2 37
  • 94 (a)
(Canis familiaris)
Mammalia TIGD2 36
  • 93.14 (n)
  • 94.67 (a)
TIGD2 37
  • 95 (a)
(Mus musculus)
Mammalia Tigd2 36
  • 86.77 (n)
  • 88.36 (a)
Tigd2 16
Tigd2 37
  • 88 (a)
(Monodelphis domestica)
Mammalia TIGD2 37
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 61 (a)
(Rattus norvegicus)
Mammalia LOC100912924 36
  • 86.7 (n)
  • 87.6 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003894 36
  • 48.22 (n)
  • 38.67 (a)
Species with no ortholog for TIGD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD2 Gene

Gene Tree for TIGD2 (if available)
Gene Tree for TIGD2 (if available)

Paralogs for TIGD2 Gene

Paralogs for TIGD2 Gene

Selected SIMAP similar genes for TIGD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD2: view

Variants for TIGD2 Gene

Sequence variations from dbSNP and Humsavar for TIGD2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8582 -- 89,114,816(+) TCTGT(A/T)GTGCC utr-variant-3-prime
rs2280099 - 89,114,398(-) TAATA(C/T)GCTTC reference, missense
rs3733448 -- 89,115,312(-) AGAAC(C/T)CAAAA downstream-variant-500B
rs12645173 -- 89,114,948(+) TTTCC(A/G)CAGCT downstream-variant-500B
rs17015027 -- 89,113,535(+) CTACC(A/G)TCAAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TIGD2 Gene

Variant ID Type Subtype PubMed ID
nsv461576 CNV Gain 19166990
nsv470051 CNV Gain 18288195

Relevant External Links for TIGD2 Gene

HapMap Linkage Disequilibrium report

Disorders for TIGD2 Gene

Relevant External Links for TIGD2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TIGD2: view

No data available for UniProtKB/Swiss-Prot for TIGD2 Gene

Publications for TIGD2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  3. Tiggers and DNA transposon fossils in the human genome. (PMID: 8643651) Smit A.F. … Riggs A.D. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Members of the pogo superfamily of DNA-mediated transposons in the human genome. (PMID: 8917322) Robertson H.M. (Mol. Gen. Genet. 1996) 3

Products for TIGD2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TIGD2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TIGD2
    • Block miRNA regulation of TIGD2 using miScript Target Protectors

    Sources for TIGD2 Gene

    Back to Top