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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIGD2 Gene

protein-coding GIFtS: 43
GCID: GC04P090033

tigger transposable element derived 2

Explore 2 diseases affiliated with
TIGD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tigger Transposable Element Derived 2¹ ²
Tigger Transposable Element-Derived Protein 2²

External Ids:	HGNC: 18333¹	Entrez Gene: 166815²	Ensembl: ENSG00000180346⁷	OMIM: 612973⁵	UniProtKB: Q4W5G0³

Export aliases for TIGD2 gene to outside databases

Previous GC identifers: GC04U990144 GC04P090335 GC04P090492 GC04P090391 GC04P090252 GC04P085785

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIGD2:

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in

humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and

mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of

this gene is not known. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIGD2 gene promoter:
Egr-3 C/EBPbeta AML1a FOXD3 C/EBPalpha MEF-2A HSF2 aMEF-2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIGD2 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q21.3

TIGD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIGD2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P090033: view genomic region (about GC identifiers)

Start:	90,033,968 bp from pter	End:	90,036,052 bp from pter
Size:	2,085 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: TIGD2_HUMAN, Q4W5G0 (See protein sequence)

Recommended Name: Tigger transposable element-derived protein 2

Size: 525 amino acids; 59623 Da

Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for TIGD2: NX_Q4W5G0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q4W5G0

TIGD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_663761.1

ENSEMBL proteins:

ENSP00000317170

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TIGD2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIGD2 for domains About GeneDecksing

4 InterPro domains/families:

IPR006600 HTH_CenpB_DNA-bd_dom

IPR004875 DDE_SF_endonuclease_CENPB-like

IPR009057 Homeodomain-like

IPR007889 HTH_Psq

Graphical View of Domain Structure for InterPro Entry Q4W5G0

ProtoNet protein and cluster: Q4W5G0

2 Blocks protein families:

IPB004875 CENP-B protein

IPB006695 CENP-B

UniProtKB/Swiss-Prot: TIGD2_HUMAN, Q4W5G0

Similarity: Belongs to the tigger transposable element derived protein family

Similarity: Contains 1 DDE domain

Similarity: Contains 1 HTH CENPB-type DNA-binding domain

Similarity: Contains 1 HTH psq-type DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

TIGD2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TIGD2:

Increased S DNA content

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TIGD2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TIGD2 gene:

NM_145715.2

Unigene Cluster for TIGD2:

Tigger transposable element derived 2

Hs.58924 [show with all ESTs]

Unigene Representative Sequence: NM_145715

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000317005(uc003hsk.3)

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Additional cDNA sequence:

AK027653.2 AL833679.1

1 DOTS entry:

DT.100020810

24/27 AceView cDNA sequences (see all 27):

BQ021688 BE326617 BM718720 C00749 NM_145715 AA677232 AI744433 BU929255

BP334478 BM467877 AI278920 AI610112 AK027653 AI348080 AI318074 CA428766

CB130942 AL833679 BU507066 CB268292 AI278732 AI052318 AA367494 BG547310

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIGD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACTATAG

About this image

TIGD2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TIGD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIGD2

SOURCE GeneReport for Unigene cluster: Hs.58924

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TIGD2 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	44(a) 38(a)	possible ortholog possible ortholog	3(135604617-135605273) GL343575.1(371492-373055)

ENSEMBL Gene Tree for TIGD2 (if available)
TreeFam Gene Tree for TIGD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TIGD2 gene

TIGD1² CENPB² TIGD6² TIGD4² TIGD7² JRKL² TIGD5² TIGD3²

5 SIMAP similar genes for TIGD2 using alignment to 1 protein entry: TIGD2_HUMAN:

JRKL TIGD1 DKFZp686C24207 TIGD7 JRK

TIGD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72877630^1,2	C	--	85784798(+)	`TACTTG/CCACCT`	1	--	ds500¹		1		WA	2
rs116708897^1,2	C,F	--	85784822(+)	`TATTCT/CGGCAA`	1	--	ds500¹		1		NA	120
rs34378169^1,2	C,F	--	90032368(+)	`TTCCCC/TCCAGC`	2	--	us2k¹ int¹		5		NA CSA WA EA	362
rs75992847^1,2		--	90032377(+)	`GCACTG/AGGGGG`	2	--	us2k¹ int¹		3		CSA NA EA	242
rs70959658^1,2	C	--	90032567(+)	`CCGGG-/CCCCCC`	2	--	int¹ us2k¹		1		NA	2
rs189321438^1,2		--	90033102(+)	`ATTTAA/GCTATC`	2	--	us2k¹ int¹		0	--	--	--	--
rs182002072^1,2		--	90033231(+)	`GCCTCC/GGAGTA`	2	--	us2k¹ ut3¹		0	--	--	--	--
rs12647095^1,2	C,H	--	90033240(+)	`TATCTA/CTACAG`	2	--	us2k¹ ut3¹		14		NA WA CSA EA	377
rs148477069^1,2		--	90033311(+)	`ACATCA/GTCTTC`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs184732210^1,2		--	90033426(+)	`CCTTTC/TCAGCT`	2	--	us2k¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TIGD2 (90033968 - 90036052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TIGD2
1 CNV: 29744

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TIGD2 for disorders           About GeneDecksing

OMIM gene information: 612973    OMIM disorders: --

2 diseases for TIGD2:    About MalaCards

intrahepatic cholangiocarcinoma cholangiocarcinoma

Export disorders for TIGD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TIGD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TIGD2)

Utopia: connect your pdf to the dynamic
world of online information

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)¹ Wang A.G....Kim N.S. (2006)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
Tiggers and DNA transposon fossils in the human genome. (PubMed id 8643651)¹ Smit A.F. and Riggs A.D. (1996)
Members of the pogo superfamily of DNA-mediated transposons in the human genome. (PubMed id 8917322)¹ Robertson H.M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 166815	HGNC: 18333	AceView: TIGD2	Ensembl:ENSG00000180346	euGenes: HUgn166815
ECgene: TIGD2	H-InvDB: TIGD2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TIGD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TIGD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TIGD2 gene:
Search GeneIP for patents involving TIGD2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TIGD2 gene at Home site.

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TIGD2 Gene

tigger transposable element derived 2

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TIGD2 Gene

tigger transposable element derived 2

Aliasesfor TIGD2 gene

Summariesfor TIGD2 gene

Genomic Viewsfor TIGD2 gene

Proteinsfor TIGD2 gene

Protein Domains /Familiesfor TIGD2 gene

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Expression for TIGD2 gene

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External Searches for TIGD2 gene

Genome Databases showing TIGD2 gene

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for TIGD2 gene

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for TIGD2 gene

Genomic Views
for TIGD2 gene

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for TIGD2 gene

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for TIGD2 gene

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for TIGD2 gene

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for TIGD2 gene

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for TIGD2 gene

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for TIGD2 gene

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Orthologs
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