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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIGD2 Gene

protein-coding   GIFtS: 43
GCID: GC04P090033

Tigger Transposable Element Derived 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tigger Transposable Element Derived 21 2
Tigger Transposable Element-Derived Protein 22

External Ids:    HGNC: 183331   Entrez Gene: 1668152   Ensembl: ENSG000001803467   OMIM: 6129735   UniProtKB: Q4W5G03   

Export aliases for TIGD2 gene to outside databases

Previous GC identifers: GC04U990144 GC04P090335 GC04P090492 GC04P090391 GC04P090252 GC04P085785


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIGD2 Gene:
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated
transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more
distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere
protein B. The exact function of this gene is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIGD2 Gene: 
TIGD2 (tigger transposable element derived 2) is a protein-coding gene. Diseases associated with TIGD2 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include DNA binding. An important paralog of this gene is JRKL.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIGD2 gene promoter:
         Egr-3   C/EBPbeta   AML1a   FOXD3   C/EBPalpha   MEF-2A   HSF2   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIGD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIGD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21.3

TIGD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIGD2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P090033:  view genomic region     (about GC identifiers)

Start:
90,033,968 bp from pter      End:
90,036,052 bp from pter
Size:
2,085 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIGD2_HUMAN, Q4W5G0 (See protein sequence)
Recommended Name: Tigger transposable element-derived protein 2  
Size: 525 amino acids; 59623 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for TIGD2: NX_Q4W5G0

Explore proteomics data for TIGD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4W5G0

  • TIGD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIGD2 Protein Expression
    REFSEQ proteins: NP_663761.1  
    ENSEMBL proteins: 
     ENSP00000317170  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TIGD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR006600 HTH_CenpB_DNA-bd_dom
     IPR004875 DDE_SF_endonuclease_CENPB-like
     IPR009057 Homeodomain-like
     IPR007889 HTH_Psq

    Graphical View of Domain Structure for InterPro Entry Q4W5G0

    ProtoNet protein and cluster: Q4W5G0

    2 Blocks protein domains:
    IPB004875 CENP-B protein
    IPB006695 CENP-B


    UniProtKB/Swiss-Prot: TIGD2_HUMAN, Q4W5G0
    Similarity: Belongs to the tigger transposable element derived protein family
    Similarity: Contains 1 DDE domain
    Similarity: Contains 1 HTH CENPB-type DNA-binding domain
    Similarity: Contains 1 HTH psq-type DNA-binding domain


    TIGD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
         
    TIGD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TIGD2:
     Increased S DNA content 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIGD2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIGD2

    Search CenterWatch for drugs/clinical trials and news about TIGD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIGD2 gene: 
    NM_145715.2  

    Unigene Cluster for TIGD2:

    Tigger transposable element derived 2
    Hs.58924  [show with all ESTs]
    Unigene Representative Sequence: NM_145715
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317005(uc003hsk.3)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGD2

    Additional mRNA sequence: 

    AK027653.2 AL833679.1 

    1 DOTS entry:

    DT.100020810 

    24/27 AceView cDNA sequences (see all 27):

    BE326617 C00749 BQ021688 BM718720 NM_145715 BU507066 CA428766 AI278920 
    BM467877 AI318074 AL833679 BP334478 AI278732 AI744433 AI610112 BU929255 
    AI348080 AK027653 CB268292 AA677232 CB130942 AI052318 BG547310 AA367494 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIGD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACTATAG
    TIGD2 Expression
    About this image


    See TIGD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIGD2

    SOURCE GeneReport for Unigene cluster: Hs.58924
        SABiosciences Custom PCR Arrays for TIGD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TIGD2 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tigd21 , 5 tigger transposable element derived 21, 5 86.77(n)1
    88.36(a)1
      6 (28.29 cM)5
    681401  NM_001081145.11  NP_001074614.11 
     592088705 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    43(a)
    38(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(135604617-135605273)
    GL343575.1(371492-373055)


    ENSEMBL Gene Tree for TIGD2 (if available)
    TreeFam Gene Tree for TIGD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIGD2 gene
    JRKL2  TIGD12  TIGD72  TIGD52  CENPB2  TIGD62  TIGD32  TIGD42  
    5 SIMAP similar genes for TIGD2 using alignment to 1 protein entry:     TIGD2_HUMAN:
    JRKL    TIGD1    DKFZp686C24207    TIGD7    JRK

    TIGD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 SNPs in TIGD2 are shown (see all 90)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809460091,2
    --90033967(+) CAAGTA/CGATTC 1 -- us2k10--------
    rs1408041461,2
    C--90034020(+) CTAGAA/GGTGAG 1 -- ut510--------
    rs170150251,2
    C,F,H--90034030(+) GAGGAG/AGAATC 1 -- ut51 ese3 trp326Minor allele frequency- A:0.18NA NS EA CSA WA 2902
    rs1503880871,2
    C,F--90034134(+) TTGGGG/AAAACG 2 /G syn12Minor allele frequency- A:0.01NA EU 5805
    rs1175964231,2
    C,F--90034191(+) AAACTT/CGAGGA 2 /L syn12Minor allele frequency- C:0.00EA NA 4628
    rs1444195941,2
    C,F--90034380(+) ATAGAG/ATGGTT 2 /E syn12Minor allele frequency- A:0.00NA EU 5651
    rs2003680281,2
    --90034385(+) GTGGTG/TTAACC 2 C F mis10--------
    rs2018588441,2
    C--90034398(+) CAGAAA/GACAGA 2 K syn10--------
    rs1492720571,2
    F--90034491(+) GCATCG/ATCAGG 2 /S syn11Minor allele frequency- A:0.00NA 3094
    rs1444728071,2
    C,F--90034595(+) TTGTGG/ATAGCT 2 /D /G mis11Minor allele frequency- A:0.00NA 3726

    HapMap Linkage Disequilibrium report for TIGD2 (90033968 - 90036052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TIGD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv470051CNV Gain18288195
    nsv461576CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612973    OMIM disorders: --

    2 diseases for TIGD2:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma


    TIGD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIGD2

    Export disorders for TIGD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIGD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TIGD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    5. Tiggers and DNA transposon fossils in the human genome. (PubMed id 8643651)1 Smit A.F. and Riggs A.D. (1996)
    6. Members of the pogo superfamily of DNA-mediated transposons in the human genome. (PubMed id 8917322)1 Robertson H.M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 166815 HGNC: 18333 AceView: TIGD2 Ensembl:ENSG00000180346 euGenes: HUgn166815
    ECgene: TIGD2 H-InvDB: TIGD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIGD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIGD2 gene:
    Search GeneIP for patents involving TIGD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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