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Aliases for TIGD2 Gene

Aliases for TIGD2 Gene

  • Tigger Transposable Element Derived 2 2 3 5
  • Tigger Transposable Element-Derived Protein 2 3
  • Epididymis Luminal Protein 106 3
  • HEL106 3

External Ids for TIGD2 Gene

Previous GeneCards Identifiers for TIGD2 Gene

  • GC04U990144
  • GC04P090335
  • GC04P090492
  • GC04P090391
  • GC04P090252
  • GC04P090033
  • GC04P085785

Summaries for TIGD2 Gene

Entrez Gene Summary for TIGD2 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD2 Gene

TIGD2 (Tigger Transposable Element Derived 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is JRKL.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD2 Gene

Genomics for TIGD2 Gene

Regulatory Elements for TIGD2 Gene

Enhancers for TIGD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F089055 0.2 ENCODE 16.3 -54.6 -54646 2.4 ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A YY1 GTF2B REST SMARCB1 TIGD2 FAM13A MMRN1 GC04P089101 GC04M088970
GH04F089020 0.6 ENCODE 14.9 -89.5 -89486 2.1 ARID1B SMARCA4 GATA2 ZNF512 TCF7 DPF2 TIGD2 FAM13A-AS1 FAM13A NAP1L5 GC04M088970 GC04P089101
GH04F089134 1.2 Ensembl ENCODE 10.7 +23.8 23795 1.3 BHLHE40 TIGD2 FAM13A RNU6-907P GC04M089241
GH04F088818 0.2 ENCODE 10.7 -290.0 -289962 6.4 HDGF PKNOX1 ARNT MLX ARID4B SIN3A YY1 CBX5 ZNF263 SP3 FAM13A TIGD2 PIR43353 LOC105377327
GH04F088997 1.5 FANTOM5 Ensembl ENCODE 10.3 -111.5 -111485 5.5 PKNOX1 ATF1 FEZF1 ELK1 TSHZ1 REST MEF2D SMARCA4 GLIS1 HMBOX1 FAM13A FAM13A-AS1 TIGD2 NAP1L5 SNCA GC04M088970 GC04P089101
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TIGD2 on UCSC Golden Path with GeneCards custom track

Promoters for TIGD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001245212 0 2201 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13

Genomic Location for TIGD2 Gene

89,111,500 bp from pter
89,114,901 bp from pter
3,402 bases
Plus strand

Genomic View for TIGD2 Gene

Genes around TIGD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD2 Gene

Proteins for TIGD2 Gene

  • Protein details for TIGD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 2
    Protein Accession:

    Protein attributes for TIGD2 Gene

    525 amino acids
    Molecular mass:
    59623 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD2 Gene

Post-translational modifications for TIGD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD2 Gene

Domains & Families for TIGD2 Gene

Gene Families for TIGD2 Gene

Suggested Antigen Peptide Sequences for TIGD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DDE-1 domain.
  • Belongs to the tigger transposable element derived protein family.
  • Contains 1 DDE-1 domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD2: view

Function for TIGD2 Gene

Gene Ontology (GO) - Molecular Function for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD2: view
genes like me logo Genes that share phenotypes with TIGD2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD2 Gene

Localization for TIGD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD2 Gene

Subcellular locations from

Jensen Localization Image for TIGD2 Gene COMPARTMENTS Subcellular localization image for TIGD2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD2: view

Pathways & Interactions for TIGD2 Gene

SuperPathways for TIGD2 Gene

No Data Available

Interacting Proteins for TIGD2 Gene

Gene Ontology (GO) - Biological Process for TIGD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD2 Gene

Transcripts for TIGD2 Gene

mRNA/cDNA for TIGD2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD2 Gene

Tigger transposable element derived 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD2 Gene

No ASD Table

Relevant External Links for TIGD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIGD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIGD2 Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for TIGD2 Gene

This gene is overexpressed in Frontal cortex (37.5) and NK cells (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIGD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD2 Gene:


SOURCE GeneReport for Unigene cluster for TIGD2 Gene:

genes like me logo Genes that share expression patterns with TIGD2: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TIGD2 Gene

Orthologs for TIGD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIGD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TIGD2 34 35
  • 93.14 (n)
(Bos Taurus)
Mammalia TIGD2 34 35
  • 92.57 (n)
(Mus musculus)
Mammalia Tigd2 34 16 35
  • 86.77 (n)
(Rattus norvegicus)
Mammalia LOC100912924 34
  • 86.7 (n)
(Monodelphis domestica)
Mammalia TIGD2 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003894 34
  • 48.22 (n)
Species where no ortholog for TIGD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD2 Gene

Gene Tree for TIGD2 (if available)
Gene Tree for TIGD2 (if available)

Paralogs for TIGD2 Gene

Paralogs for TIGD2 Gene

(5) SIMAP similar genes for TIGD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD2: view

Variants for TIGD2 Gene

Sequence variations from dbSNP and Humsavar for TIGD2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs111450146 -- 89,114,539(+) AAATA(A/G)CAAAA reference, missense
rs112541524 -- 89,113,845(+) TTCTT(C/T)TAGAT reference, synonymous-codon
rs116708897 -- 89,112,610(+) TATTC(C/T)GGCAA upstream-variant-2KB
rs117596423 -- 89,113,040(+) AAACT(C/T)GAGGA upstream-variant-2KB, reference, synonymous-codon
rs117877123 -- 89,112,690(+) AGTTT(C/T)TAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TIGD2 Gene

Variant ID Type Subtype PubMed ID
esv3569577 CNV loss 25503493
nsv461576 CNV gain 19166990
nsv470051 CNV gain 18288195
nsv594806 CNV gain 21841781

Variation tolerance for TIGD2 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD2 Gene

Disorders for TIGD2 Gene

Relevant External Links for TIGD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIGD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD2 Gene

Publications for TIGD2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3 64
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3 64
  5. Tiggers and DNA transposon fossils in the human genome. (PMID: 8643651) Smit A.F. … Riggs A.D. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 64

Products for TIGD2 Gene

Sources for TIGD2 Gene

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