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Aliases for TIGD1 Gene

Aliases for TIGD1 Gene

  • Tigger Transposable Element Derived 1 2 3 5
  • Tigger Transposable Element-Derived Protein 1 3
  • EEYORE 3

External Ids for TIGD1 Gene

Previous GeneCards Identifiers for TIGD1 Gene

  • GC02M231469
  • GC02M232142
  • GC02M233376
  • GC02M233615
  • GC02M233238
  • GC02M233121
  • GC02M225263

Summaries for TIGD1 Gene

Entrez Gene Summary for TIGD1 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD1 Gene

TIGD1 (Tigger Transposable Element Derived 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD1 Gene

Genomics for TIGD1 Gene

Regulatory Elements for TIGD1 Gene

Enhancers for TIGD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TIGD1 on UCSC Golden Path with GeneCards custom track

Promoters for TIGD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TIGD1 Gene

232,547,968 bp from pter
232,550,592 bp from pter
2,625 bases
Minus strand

Genomic View for TIGD1 Gene

Genes around TIGD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD1 Gene

Proteins for TIGD1 Gene

  • Protein details for TIGD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6P4D2
    • Q6PIF9

    Protein attributes for TIGD1 Gene

    591 amino acids
    Molecular mass:
    67299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD1 Gene

Post-translational modifications for TIGD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD1 Gene

Domains & Families for TIGD1 Gene

Gene Families for TIGD1 Gene

Protein Domains for TIGD1 Gene

Suggested Antigen Peptide Sequences for TIGD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DDE domain.
  • Belongs to the tigger transposable element derived protein family.
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD1: view

Function for TIGD1 Gene

Gene Ontology (GO) - Molecular Function for TIGD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD1: view
genes like me logo Genes that share phenotypes with TIGD1: view

Animal Model Products

CRISPR Products

miRNA for TIGD1 Gene

miRTarBase miRNAs that target TIGD1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD1 Gene

Localization for TIGD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD1 Gene

Subcellular locations from

Jensen Localization Image for TIGD1 Gene COMPARTMENTS Subcellular localization image for TIGD1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TIGD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD1: view

Pathways & Interactions for TIGD1 Gene

SuperPathways for TIGD1 Gene

No Data Available

Interacting Proteins for TIGD1 Gene

Gene Ontology (GO) - Biological Process for TIGD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD1 Gene

Drugs & Compounds for TIGD1 Gene

No Compound Related Data Available

Transcripts for TIGD1 Gene

mRNA/cDNA for TIGD1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD1 Gene

Tigger transposable element derived 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD1 Gene

No ASD Table

Relevant External Links for TIGD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD1 Gene

mRNA expression in normal human tissues for TIGD1 Gene

Protein differential expression in normal tissues from HIPED for TIGD1 Gene

This gene is overexpressed in Breast (54.4) and Synovial fluid (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIGD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD1 Gene:


SOURCE GeneReport for Unigene cluster for TIGD1 Gene:

genes like me logo Genes that share expression patterns with TIGD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TIGD1 Gene

Orthologs for TIGD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101902808 34
  • 89.69 (n)
  • 87.29 (a)
(Pan troglodytes)
Mammalia TIGD1 34
  • 99.27 (n)
  • 99.32 (a)
TIGD1 35
  • 99 (a)
(Canis familiaris)
Mammalia TIGD1 35
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 24 (a)
-- 35
  • 36 (a)
-- 35
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia TIGD1 35
  • 40 (a)
(Anolis carolinensis)
Reptilia TIGD1 35
  • 53 (a)
Species where no ortholog for TIGD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD1 Gene

Gene Tree for TIGD1 (if available)
Gene Tree for TIGD1 (if available)

Paralogs for TIGD1 Gene

Paralogs for TIGD1 Gene

(2) SIMAP similar genes for TIGD1 Gene using alignment to 1 proteins: Pseudogenes for TIGD1 Gene

genes like me logo Genes that share paralogs with TIGD1: view

Variants for TIGD1 Gene

Sequence variations from dbSNP and Humsavar for TIGD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs146398054 -- 232,548,037(+) TGCAA(C/T)AGCAT utr-variant-3-prime
rs192806094 -- 232,548,052(+) TAATA(A/C)AACAA utr-variant-3-prime
rs187560207 -- 232,547,675(+) GAGTG(A/G)GGGAG downstream-variant-500B
rs112969708 -- 232,547,573(+) AGTTC(A/G)TATTA downstream-variant-500B
rs113546674 -- 232,547,634(+) AGAGC(A/T)GAGTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TIGD1 Gene

Variant ID Type Subtype PubMed ID
nsv3212 CNV deletion 18451855
nsv821918 CNV gain 20364138

Variation tolerance for TIGD1 Gene

Gene Damage Index Score: 2.39; 42.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIGD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD1 Gene

Disorders for TIGD1 Gene

Relevant External Links for TIGD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIGD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD1 Gene

Publications for TIGD1 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 65
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 65

Products for TIGD1 Gene

Sources for TIGD1 Gene

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