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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIGD1 Gene

protein-coding   GIFtS: 43
GCID: GC02M233376

Tigger Transposable Element Derived 1

  Search for TIGD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tigger Transposable Element Derived 11 2
EEYORE2
Tigger Transposable Element-Derived Protein 12

External Ids:    HGNC: 145231   Entrez Gene: 2007652   Ensembl: ENSG000002219447   OMIM: 6129725   UniProtKB: Q96MW73   

Export aliases for TIGD1 gene to outside databases

Previous GC identifers: GC02M231469 GC02M232142 GC02M233615 GC02M233238 GC02M233121 GC02M225263


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIGD1 Gene:
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated
transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more
distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere
protein B. The exact function of this gene is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIGD1 Gene: 
TIGD1 (tigger transposable element derived 1) is a protein-coding gene. GO annotations related to this gene include DNA binding. An important paralog of this gene is TIGD2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIGD1 gene promoter:
         HFH-3   SRF (504 AA)   NRSF form 1   AP-4   Nkx2-5   NRSF form 2   FOXI1   IRF-2   Nkx6-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIGD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIGD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

TIGD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIGD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M233376:  view genomic region     (about GC identifiers)

Start:
233,412,779 bp from pter      End:
233,415,226 bp from pter
Size:
2,448 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TIGD1_HUMAN, Q96MW7 (See protein sequence)
Recommended Name: Tigger transposable element-derived protein 1  
Size: 591 amino acids; 67299 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q6P4D2 Q6PIF9

Explore the universe of human proteins at neXtProt for TIGD1: NX_Q96MW7

Explore proteomics data for TIGD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MW7

  • TIGD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TIGD1 Protein Expression
    REFSEQ proteins: NP_663748.1  
    ENSEMBL proteins: 
     ENSP00000386186  

    Human Recombinant Protein Products for TIGD1: 
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    Cloud-Clone Corp. Proteins for TIGD1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TIGD1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR006600 HTH_CenpB_DNA-bd_dom
     IPR004875 DDE_SF_endonuclease_CENPB-like
     IPR009057 Homeodomain-like
     IPR007889 HTH_Psq

    Graphical View of Domain Structure for InterPro Entry Q96MW7

    ProtoNet protein and cluster: Q96MW7

    UniProtKB/Swiss-Prot: TIGD1_HUMAN, Q96MW7
    Similarity: Belongs to the tigger transposable element derived protein family
    Similarity: Contains 1 DDE domain
    Similarity: Contains 1 HTH CENPB-type DNA-binding domain
    Similarity: Contains 1 HTH psq-type DNA-binding domain


    TIGD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
         
    TIGD1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TIGD1:
     Increased S DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIGD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TIGD1 (ENSP000003861864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAENSP000003684384STRING: ENSP00000368438
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIGD1

    Search CenterWatch for drugs/clinical trials and news about TIGD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TIGD1 gene: 
    NM_145702.1  

    Unigene Cluster for TIGD1:

    Tigger transposable element derived 1
    Hs.211823  [show with all ESTs]
    Unigene Representative Sequence: BC035143
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000408957(uc002vsy.1)
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TIGD1 (NM_145702)
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                         Customized lentivirus expression plasmids for stable overexpression of TIGD1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIGD1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIGD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGD1

    Additional mRNA sequence: 

    AK056329.1 BC035143.1 BC063500.1 

    3 DOTS entries:

    DT.97820733  DT.40310392  DT.121030437 

    24/84 AceView cDNA sequences (see all 84):

    BQ888774 N24942 BQ878067 BQ896861 BQ899110 NM_145702 BQ685032 AK056329 
    BQ688350 AI144166 BC063500 BQ687669 CA430123 BU728674 BU616791 BU622317 
    BX952645 BQ691071 BU190792 BQ894838 BQ689687 BQ685738 BQ687268 BM668477 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIGD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TIGD1 Expression
    About this image


    See TIGD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIGD1

    SOURCE GeneReport for Unigene cluster: Hs.211823
        SABiosciences Custom PCR Arrays for TIGD1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TIGD1 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC1008560861 tigger transposable element-derived protein 1-like 49.5(n)
    42.56(a)
      100856086  XM_003638849.1  XP_003638897.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIGD16
    --
    (see all 11)
    Uncharacterized protein
    (see all 11)
    53(a)
    42(a)
    (see all 11)
    1 ↔ 1
    possible ortholog
    (see all 11)
    2(196204927-196205808)
    1(111866077-111867314)
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0000261 AGAP000026-PA 44.21(n)
    33.79(a)
      1272251  XM_311135.4  XP_311135.4 


    ENSEMBL Gene Tree for TIGD1 (if available)
    TreeFam Gene Tree for TIGD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIGD1 gene
    TIGD22  JRKL2  TIGD72  TIGD52  CENPB2  TIGD62  TIGD32  TIGD42  
    2 SIMAP similar genes for TIGD1 using alignment to 1 protein entry:     TIGD1_HUMAN:
    CENPBD1    TIGD2

    TIGD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TIGD1
    PGOHUM00000236396


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/97 SNPs in TIGD1 are shown (see all 97)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129697081,2
    F--232784919(+) AGTTCG/ATATTA 1 -- ds50012Minor allele frequency- A:0.50CSA 4
    rs1875602071,2
    --232785021(+) GAGTGA/GGGGAG 1 -- ds50010--------
    rs1463980541,2
    --232785383(+) TGCAAC/TAGCAT 1 -- ds50010--------
    rs1928060941,2
    C--232785398(+) TAATAA/CAACAA 1 -- ds50010--------
    rs49735391,2
    C,F,H--232785456(+) tatcaA/Gtctga 2 D syn120Minor allele frequency- G:0.14NS EA NA WA 2538
    rs3723628361,2
    C--232785467(+) GCCTTC/TGGTGA 2 K E mis10--------
    rs1840816701,2
    C--232785508(+) GCCTCA/GAGGTT 2 S L mis10--------
    rs1888098131,2
    C--232785547(+) CTGCTA/GAAGGT 2 S L mis10--------
    rs1920476001,2
    C--232785602(+) TTTTCA/GCATGA 2 R * stg10--------
    rs1845486851,2
    --232785648(+) CATGCA/GATGCT 2 I syn10--------

    HapMap Linkage Disequilibrium report for TIGD1 (233412779 - 233415226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TIGD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv875977CNV Loss21882294
    nsv875998CNV Loss21882294
    dgv4454n71CNV Loss21882294
    nsv3212CNV Loss18451855
    nsv821918CNV Gain20364138
    nsv876000CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TIGD1 for disorders           About MalaCards
    OMIM gene information: 612972    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TIGD1:
    Plague

    TIGD1 for disorders           About GeneDecksing


    Export disorders for TIGD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIGD1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TIGD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Tiggers and DNA transposon fossils in the human genome. (PubMed id 8643651)1 Smit A.F. and Riggs A.D. (1996)
    8. Members of the pogo superfamily of DNA-mediated transposons in the human genome. (PubMed id 8917322)1 Robertson H.M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200765 HGNC: 14523 AceView: TIGD1 Ensembl:ENSG00000221944 euGenes: HUgn200765
    ECgene: TIGD1 H-InvDB: TIGD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIGD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TIGD1 gene:
    Search GeneIP for patents involving TIGD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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