TIGD1 Gene
protein-coding GIFtS: 41
GCID: GC02M233376
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tigger transposable element derived 1
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Aliases
for TIGD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tigger Transposable Element Derived 11 2 | | EEYORE1 2 | | Tigger Transposable Element-Derived Protein 12 |
Export aliases for TIGD1 gene to outside databasesPrevious GC identifers: GC02M231469 GC02M232142 GC02M233615 GC02M233238 GC02M233121 GC02M225263 |
Summaries
for TIGD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TIGD1:
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons inhumans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 andmariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function ofthis gene is not known. (provided by RefSeq, Jul 2008)
|
Genomic Views
for TIGD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TIGD1 gene promoter:
HFH-3 SRF (504 AA) NRSF form 1 AP-4 Nkx2-5 NRSF form 2 FOXI1 IRF-2 Nkx6-1 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIGD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1TIGD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M233376: view genomic region
(about GC identifiers)
Start:
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233,412,779 bp from pter |
End:
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233,415,226 bp from pter |
Size:
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2,448 bases |
Orientation:
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minus strand |
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Proteins
for TIGD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIGD1_HUMAN, Q96MW7 (See
protein sequence)Recommended Name: Tigger transposable element-derived protein 1 Size: 591 amino acids; 67299 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q6P4D2 Q6PIF9Explore the universe of human proteins at neXtProt for TIGD1: NX_Q96MW7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MW7
TIGD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_663748.1
ENSEMBL proteins: ENSP00000386186
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TIGD1 for ontologies About GeneDecksing
TIGD1 Antibody Products:
Assay Products for TIGD1: |
Protein
Domains /
Families
for TIGD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIGD1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96MW7ProtoNet protein and cluster: Q96MW7 UniProtKB/Swiss-Prot: TIGD1_HUMAN, Q96MW7Similarity: Belongs to the tigger transposable element derived protein familySimilarity: Contains 1 DDE domainSimilarity: Contains 1 HTH CENPB-type DNA-binding domainSimilarity: Contains 1 HTH psq-type DNA-binding domain |
Function
for TIGD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TIGD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
TIGD1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TIGD1:
|
Pathways & Interactions
for TIGD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIGD1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TIGD1 (ENSP000003861864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TIGD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TIGD1
Search CenterWatch for drugs/clinical trials and news about TIGD1
|
Transcripts
for TIGD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TIGD1 gene: NM_145702.1 Unigene Cluster for TIGD1: Tigger transposable element derived 1 Hs.211823 [show with all ESTs]Unigene Representative Sequence: BC0351431 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000408957(uc002vsy.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIGD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TIGD1 (NM_145702) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIGD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD1 |
Additional cDNA sequence: AK056329.1 BC035143.1 BC063500.1 3 DOTS entries: DT.97820733 DT.40310392 DT.121030437 24/84 AceView cDNA sequences (see all 84): BQ899110 BQ687194 BU622317 BU179659 BQ688003 BQ685032 AI144166 BQ688928 BQ896861 N24942 BC063500 BM703722 BU728674 BQ686807 BQ688350 BU190792 BQ888774 BQ685738 BM668477 BU196981 BQ687268 AA331774 BQ685449 CA430123
GeneLoc Exon Structure
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Expression
for TIGD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIGD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TIGD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIGD1
SOURCE GeneReport for Unigene cluster: Hs.211823
SABiosciences Custom PCR Arrays for TIGD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIGD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TIGD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIGD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD1 |
Orthologs
for TIGD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TIGD1 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for TIGD1 (if available)
TreeFam Gene Tree for TIGD1 (if available) |
Paralogs
for TIGD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TIGD1 gene
- TIGD22 JRKL2 TIGD72 TIGD52 CENPB2 TIGD62 TIGD32 TIGD42
2 SIMAP similar genes for TIGD1 using alignment to 1 protein entry: TIGD1_HUMAN:CENPBD1 TIGD2
TIGD1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TIGD1
PGOHUM00000236396
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Genomic Variants
for TIGD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TIGD1 (233412779 - 233415226 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIGD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIGD1 |
|
Disorders
/ Diseases
for TIGD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TIGD1 for disorders About GeneDecksing
OMIM gene information: 612972
OMIM disorders: --
1  disease for TIGD1: About MalaCardstuberculosis
1 disease from the University of Copenhagen DISEASES database for TIGD1:Plague Export disorders for TIGD1 gene to outside databases
|
Publications
for TIGD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIGD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TIGD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Tiggers and DNA transposon fossils in the human genome. (PubMed id 8643651)1 Smit A.F. and Riggs A.D. (1996)
- Members of the pogo superfamily of DNA-mediated transposons in the human genome. (PubMed id 8917322)1 Robertson H.M. (1996)
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External Searches for TIGD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TIGD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIGD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIGD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TIGD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TIGD1 gene:
Search GeneIP for patents involving TIGD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIGD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for TIGD1 | | OriGene Custom Protein Services for TIGD1 | | | OriGene Custom Immunoassay Development | | |
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 | | | TIGD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TIGD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGD1 |
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