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Aliases for TIGAR Gene

Aliases for TIGAR Gene

  • TP53 Induced Glycolysis Regulatory Phosphatase 2 3
  • TP53-Induced Glycolysis And Apoptosis Regulator 2 3 4
  • C12orf5 3 4 6
  • Probable Fructose-2,6-Bisphosphatase TIGAR 3
  • Fructose-2,6-Bisphosphate 2-Phosphatase 3
  • Chromosome 12 Open Reading Frame 5 2
  • Fructose-2,6-Bisphosphatase TIGAR 3
  • Transactivated By NS3TP2 Protein 3
  • EC 3.1.3.46 4
  • FR2BP 3

External Ids for TIGAR Gene

Previous Symbols for TIGAR Gene

  • C12orf5

Summaries for TIGAR Gene

Entrez Gene Summary for TIGAR Gene

  • This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGAR Gene

TIGAR (TP53 Induced Glycolysis Regulatory Phosphatase) is a Protein Coding gene. Among its related pathways are Direct p53 effectors and Fructose and mannose metabolism.

UniProtKB/Swiss-Prot for TIGAR Gene

  • Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.

Gene Wiki entry for TIGAR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGAR Gene

Genomics for TIGAR Gene

Genomic Location for TIGAR Gene

Start:
4,321,193 bp from pter
End:
4,360,028 bp from pter
Size:
38,836 bases
Orientation:
Plus strand

Genomic View for TIGAR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIGAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGAR Gene

No data available for Regulatory Elements for TIGAR Gene

Proteins for TIGAR Gene

  • Protein details for TIGAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ88-TIGAR_HUMAN
    Recommended name:
    Fructose-2,6-bisphosphatase TIGAR
    Protein Accession:
    Q9NQ88
    Secondary Accessions:
    • B2R840

    Protein attributes for TIGAR Gene

    Size:
    270 amino acids
    Molecular mass:
    30063 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for TIGAR Gene

neXtProt entry for TIGAR Gene

Proteomics data for TIGAR Gene at MOPED

Post-translational modifications for TIGAR Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys37

Other Protein References for TIGAR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGAR Gene

Domains for TIGAR Gene

UniProtKB/Swiss-Prot:

TIGAR_HUMAN
Family:
  • Belongs to the phosphoglycerate mutase family.:
    • Q9NQ88
genes like me logo Genes that share domains with TIGAR: view

No data available for Gene Families for TIGAR Gene

Function for TIGAR Gene

Molecular function for TIGAR Gene

UniProtKB/Swiss-Prot CatalyticActivity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
UniProtKB/Swiss-Prot Function: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.
UniProtKB/Swiss-Prot Induction: Rapidly up-regulated by p53/TP53.

Enzyme Numbers (IUBMB) for TIGAR Gene

Gene Ontology (GO) - Molecular Function for TIGAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA --
GO:0016791 phosphatase activity IBA --
genes like me logo Genes that share ontologies with TIGAR: view
genes like me logo Genes that share phenotypes with TIGAR: view

Animal Models for TIGAR Gene

MGI Knock Outs for TIGAR:

miRNA for TIGAR Gene

miRTarBase miRNAs that target TIGAR

No data available for Transcription Factor Targeting and HOMER Transcription for TIGAR Gene

Localization for TIGAR Gene

Gene Ontology (GO) - Cellular Components for TIGAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TIGAR: view

Pathways for TIGAR Gene

genes like me logo Genes that share pathways with TIGAR: view

Pathways by source for TIGAR Gene

1 BioSystems pathway for TIGAR Gene
1 KEGG pathway for TIGAR Gene

Interacting Proteins for TIGAR Gene

Gene Ontology (GO) - Biological Process for TIGAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0009410 response to xenobiotic stimulus IEA --
GO:0010332 response to gamma radiation IEA --
GO:0010467 gene expression TAS --
GO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA --
genes like me logo Genes that share ontologies with TIGAR: view

Transcripts for TIGAR Gene

mRNA/cDNA for TIGAR Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TIGAR Gene

No ASD Table

Relevant External Links for TIGAR Gene

GeneLoc Exon Structure for
TIGAR
ECgene alternative splicing isoforms for
TIGAR

Expression for TIGAR Gene

mRNA expression in normal human tissues for TIGAR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIGAR Gene

genes like me logo Genes that share expressions with TIGAR: view

Orthologs for TIGAR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIGAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf5 36
  • 99.51 (n)
  • 98.89 (a)
C12orf5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf5 36
  • 83.4 (n)
  • 81.78 (a)
TIGAR 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12orf5 37
  • 84 (a)
OneToOne
C27H12orf5 36
  • 86.86 (n)
  • 84.76 (a)
mouse
(Mus musculus)
Mammalia 9630033F20Rik 36
  • 75.56 (n)
  • 73.31 (a)
9630033F20Rik 16
9630033F20Rik 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C12orf5 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C12orf5 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1308005 36
  • 75.17 (n)
  • 73.71 (a)
chicken
(Gallus gallus)
Aves C12orf5 37
  • 55 (a)
OneToOne
C1H12ORF5 36
  • 67.18 (n)
  • 60.15 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf5 36
  • 58.77 (n)
  • 53.38 (a)
zebrafish
(Danio rerio)
Actinopterygii C25H12orf5 (2 of 2) 37
  • 38 (a)
OneToMany
C4H12orf5 (1 of 2) 37
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToOne
Species with no ortholog for TIGAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIGAR Gene

ENSEMBL:
Gene Tree for TIGAR (if available)
TreeFam:
Gene Tree for TIGAR (if available)

Paralogs for TIGAR Gene

No data available for Paralogs for TIGAR Gene

Variants for TIGAR Gene

Sequence variations from dbSNP and Humsavar for TIGAR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1046161 -- 4,352,874(+) TTGTC(C/T)AAGTA utr-variant-3-prime
rs1046164 -- 4,352,980(+) GATTA(A/G)TAACC utr-variant-3-prime
rs1046165 -- 4,352,995(+) TACAA(C/T)GGTTT utr-variant-3-prime
rs1861914 -- 4,337,406(-) GAGGC(A/G)AGTGG intron-variant
rs2358726 -- 4,358,153(+) tggtg(A/G)ctcag utr-variant-3-prime

Relevant External Links for TIGAR Gene

HapMap Linkage Disequilibrium report
TIGAR

No data available for Structural Variations from Database of Genomic Variants (DGV) for TIGAR Gene

Disorders for TIGAR Gene

No disorders were found for TIGAR Gene.

No data available for UniProtKB/Swiss-Prot for TIGAR Gene

Publications for TIGAR Gene

  1. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. (PMID: 16839880) Bensaad K. … Vousden K.H. (Cell 2006) 2 3 4
  2. Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells. (PMID: 18945750) LA^pez-Guerra M. … Pastor-Anglada M. (Haematologica 2008) 2 3
  3. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PMID: 11062477) White K.E. … Strom T.M. (Nat. Genet. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of novel p53 target genes in ionizing radiation response. (PMID: 16140933) Jen K.Y. … Cheung V.G. (Cancer Res. 2005) 2 3

Products for TIGAR Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TIGAR
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TIGAR
    • Block miRNA regulation of TIGAR using miScript Target Protectors

    Sources for TIGAR Gene

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