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Aliases for TIFAB Gene

Aliases for TIFAB Gene

  • TRAF-Interacting Protein With Forkhead-Associated Domain, Family Member B 2 3
  • TIFA-Like Protein 4

External Ids for TIFAB Gene

Previous GeneCards Identifiers for TIFAB Gene

  • GC05U900526
  • GC05M134813
  • GC05M129972

Summaries for TIFAB Gene

Entrez Gene Summary for TIFAB Gene

  • TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]

GeneCards Summary for TIFAB Gene

TIFAB (TRAF-Interacting Protein With Forkhead-Associated Domain, Family Member B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIFAB Gene

  • Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFAB Gene

Genomics for TIFAB Gene

Regulatory Elements for TIFAB Gene

Genomic Location for TIFAB Gene

Chromosome:
5
Start:
135,444,218 bp from pter
End:
135,452,399 bp from pter
Size:
8,182 bases
Orientation:
Minus strand

Genomic View for TIFAB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TIFAB Gene

Proteins for TIFAB Gene

  • Protein details for TIFAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNK6-TIFAB_HUMAN
    Recommended name:
    TRAF-interacting protein with FHA domain-containing protein B
    Protein Accession:
    Q6ZNK6
    Secondary Accessions:
    • Q5H8A9

    Protein attributes for TIFAB Gene

    Size:
    161 amino acids
    Molecular mass:
    17888 Da
    Quaternary structure:
    • Interacts with TIFA.
    SequenceCaution:
    • Sequence=BAC85138.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TIFAB Gene

Proteomics data for TIFAB Gene at MOPED

Post-translational modifications for TIFAB Gene

No Post-translational modifications

Other Protein References for TIFAB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIFAB Gene

Domains & Families for TIFAB Gene

Protein Domains for TIFAB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIFAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNK6

UniProtKB/Swiss-Prot:

TIFAB_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with TIFAB: view

No data available for Gene Families for TIFAB Gene

Function for TIFAB Gene

Molecular function for TIFAB Gene

UniProtKB/Swiss-Prot Function:
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.

Gene Ontology (GO) - Molecular Function for TIFAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TIFAB: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TIFAB Gene

Localization for TIFAB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TIFAB Gene

Pathways & Interactions for TIFAB Gene

SuperPathways for TIFAB Gene

No Data Available

Interacting Proteins for TIFAB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000440509%0d%0a9606.ENSP00000354911%0d%0a
Selected Interacting proteins: ENSP00000440509 Q6ZNK6-TIFAB_HUMAN for TIFAB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TIFAB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIFAB Gene

Drugs & Compounds for TIFAB Gene

No Compound Related Data Available

Transcripts for TIFAB Gene

mRNA/cDNA for TIFAB Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIFAB Gene

TRAF-interacting protein with forkhead-associated domain, family member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIFAB Gene

No ASD Table

Relevant External Links for TIFAB Gene

GeneLoc Exon Structure for
TIFAB
ECgene alternative splicing isoforms for
TIFAB

Expression for TIFAB Gene

mRNA expression in normal human tissues for TIFAB Gene

Protein differential expression in normal tissues from HIPED for TIFAB Gene

This gene is overexpressed in Monocytes (41.3) and Tlymphocyte (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIFAB Gene



SOURCE GeneReport for Unigene cluster for TIFAB Gene Hs.552091

genes like me logo Genes that share expression patterns with TIFAB: view

Protein tissue co-expression partners for TIFAB Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIFAB Gene

Orthologs for TIFAB Gene

This gene was present in the common ancestor of mammals.

Orthologs for TIFAB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIFAB 35
  • 81.57 (n)
  • 77.02 (a)
TIFAB 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIFAB 35
  • 84.6 (n)
  • 79.75 (a)
TIFAB 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tifab 35
  • 80.95 (n)
  • 80.27 (a)
Tifab 16
Tifab 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIFAB 35
  • 99.38 (n)
  • 98.76 (a)
TIFAB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tifab 35
  • 81.86 (n)
  • 79.59 (a)
oppossum
(Monodelphis domestica)
Mammalia TIFAB 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIFAB 36
  • 47 (a)
OneToOne
Species with no ortholog for TIFAB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIFAB Gene

ENSEMBL:
Gene Tree for TIFAB (if available)
TreeFam:
Gene Tree for TIFAB (if available)

Paralogs for TIFAB Gene

No data available for Paralogs for TIFAB Gene

Variants for TIFAB Gene

Variation tolerance for TIFAB Gene

Residual Variation Intolerance Score: 74.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIFAB Gene

HapMap Linkage Disequilibrium report
TIFAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TIFAB Gene

Disorders for TIFAB Gene

Relevant External Links for TIFAB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIFAB
genes like me logo Genes that share disorders with TIFAB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIFAB Gene

Publications for TIFAB Gene

  1. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PMID: 15047173) Matsumura T. … Inoue J. (Biochem. Biophys. Res. Commun. 2004) 2 23 67
  2. TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions. (PMID: 19470519) Matsumura T. … Inoue J. (J. Biochem. 2009) 23 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 67

Products for TIFAB Gene

Sources for TIFAB Gene

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