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Aliases for TIFAB Gene

Aliases for TIFAB Gene

  • TRAF-Interacting Protein With Forkhead-Associated Domain, Family Member B 2 3
  • TIFA-Like Protein 4

External Ids for TIFAB Gene

Previous GeneCards Identifiers for TIFAB Gene

  • GC05U900526
  • GC05M134813
  • GC05M129972

Summaries for TIFAB Gene

Entrez Gene Summary for TIFAB Gene

  • TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]

GeneCards Summary for TIFAB Gene

TIFAB (TRAF-Interacting Protein With Forkhead-Associated Domain, Family Member B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIFAB Gene

  • Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFAB Gene

Genomics for TIFAB Gene

Regulatory Elements for TIFAB Gene

Genomic Location for TIFAB Gene

135,444,218 bp from pter
135,452,399 bp from pter
8,182 bases
Minus strand

Genomic View for TIFAB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIFAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIFAB Gene

Proteins for TIFAB Gene

  • Protein details for TIFAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRAF-interacting protein with FHA domain-containing protein B
    Protein Accession:
    Secondary Accessions:
    • Q5H8A9

    Protein attributes for TIFAB Gene

    161 amino acids
    Molecular mass:
    17888 Da
    Quaternary structure:
    • Interacts with TIFA.
    • Sequence=BAC85138.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TIFAB Gene

Proteomics data for TIFAB Gene at MOPED

Post-translational modifications for TIFAB Gene

No Post-translational modifications

Other Protein References for TIFAB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIFAB Gene

Domains for TIFAB Gene

Protein Domains for TIFAB Gene


Suggested Antigen Peptide Sequences for TIFAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FHA domain.
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with TIFAB: view

No data available for Gene Families for TIFAB Gene

Function for TIFAB Gene

Molecular function for TIFAB Gene

UniProtKB/Swiss-Prot Function:
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.

Gene Ontology (GO) - Molecular Function for TIFAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TIFAB: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIFAB Gene

Localization for TIFAB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TIFAB Gene

Pathways for TIFAB Gene

SuperPathways for TIFAB Gene

No Data Available

Interacting Proteins for TIFAB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000440509 Q6ZNK6-TIFAB_HUMAN for TIFAB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TIFAB Gene


No data available for Pathways by source for TIFAB Gene

Transcripts for TIFAB Gene

mRNA/cDNA for TIFAB Gene

(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIFAB Gene

TRAF-interacting protein with forkhead-associated domain, family member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIFAB Gene

No ASD Table

Relevant External Links for TIFAB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIFAB Gene

mRNA expression in normal human tissues for TIFAB Gene

Protein differential expression in normal tissues for TIFAB Gene

This gene is overexpressed in Monocytes (41.3) and Tlymphocyte (27.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TIFAB Gene

SOURCE GeneReport for Unigene cluster for TIFAB Gene Hs.552091

genes like me logo Genes that share expressions with TIFAB: view

Expression partners for TIFAB Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIFAB Gene

Orthologs for TIFAB Gene

This gene was present in the common ancestor of mammals.

Orthologs for TIFAB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TIFAB 35
  • 81.57 (n)
  • 77.02 (a)
  • 77 (a)
(Canis familiaris)
Mammalia TIFAB 35
  • 84.6 (n)
  • 79.75 (a)
  • 65 (a)
(Mus musculus)
Mammalia Tifab 35
  • 80.95 (n)
  • 80.27 (a)
Tifab 16
Tifab 36
  • 80 (a)
(Pan troglodytes)
Mammalia TIFAB 35
  • 99.38 (n)
  • 98.76 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tifab 35
  • 81.86 (n)
  • 79.59 (a)
(Monodelphis domestica)
Mammalia TIFAB 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia TIFAB 36
  • 47 (a)
Species with no ortholog for TIFAB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIFAB Gene

Gene Tree for TIFAB (if available)
Gene Tree for TIFAB (if available)

Paralogs for TIFAB Gene

No data available for Paralogs for TIFAB Gene

Variants for TIFAB Gene

Sequence variations from dbSNP and Humsavar for TIFAB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6596227 -- 135,452,604(+) GAAAA(A/G)AAGAG upstream-variant-2KB
rs6596228 -- 135,453,052(+) ttttt(A/C)tgaca upstream-variant-2KB
rs6596229 -- 135,453,185(+) aaaga(C/T)tggtt upstream-variant-2KB
rs6889333 -- 135,451,945(+) TTCAC(A/T)GTTGC intron-variant
rs6889578 -- 135,451,802(+) TCGAG(A/G)TATGC intron-variant

Relevant External Links for TIFAB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIFAB Gene

Disorders for TIFAB Gene

No disorders were found for TIFAB Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TIFAB Gene

Publications for TIFAB Gene

  1. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PMID: 15047173) Matsumura T. … Inoue J. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions. (PMID: 19470519) Matsumura T. … Inoue J. (J. Biochem. 2009) 23
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for TIFAB Gene

Sources for TIFAB Gene

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