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Aliases for TIFAB Gene

Aliases for TIFAB Gene

  • TIFA Inhibitor 2 3 5
  • TRAF-Interacting Protein With Forkhead-Associated Domain, Family Member B 2
  • TIFA-Like Protein 4

External Ids for TIFAB Gene

Previous GeneCards Identifiers for TIFAB Gene

  • GC05U900526
  • GC05M134813
  • GC05M129972

Summaries for TIFAB Gene

Entrez Gene Summary for TIFAB Gene

  • TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]

GeneCards Summary for TIFAB Gene

TIFAB (TIFA Inhibitor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIFAB Gene

  • Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFAB Gene

Genomics for TIFAB Gene

Regulatory Elements for TIFAB Gene

Enhancers for TIFAB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G135455 1.7 FANTOM5 Ensembl ENCODE 12.2 -4.2 -4248 2.1 PKNOX1 ATF1 CREB3L1 ZNF2 ZNF48 TCF12 ZNF766 CBX5 ZNF143 FOS TIFAB ENSG00000250167 CXCL14 H2AFY NEUROG1
GH05G135488 1.5 Ensembl ENCODE dbSUPER 5.9 -37.4 -37446 2.2 FOXA2 ZNF48 GLIS2 KLF7 ZNF263 SP3 SP5 NFYC ZNF610 SMARCA4 NEUROG1 ENSG00000250167 CXCL14 TIFAB ENSG00000249639 JADE2 ENSG00000270021
GH05G135493 1.1 Ensembl ENCODE dbSUPER 6.5 -41.5 -41454 1.6 JUN CEBPB EP300 FOSL1 JUND ZBTB48 STAT3 FOS MAFK NFE2L2 TIFAB NEUROG1
GH05G135450 0.4 Ensembl 9.2 +0.7 699 1.8 ZNF121 PAF1 TIFAB ENSG00000249639
GH05G135482 1.3 ENCODE dbSUPER 0.3 -30.0 -29971 0.6 HDGF FOXA2 MLX ARID4B DMAP1 GLI4 ZNF48 GATA2 ZNF416 ZNF207 ENSG00000250167 NEUROG1 CXCL14 ENSG00000254239 TIFAB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIFAB on UCSC Golden Path with GeneCards custom track

Genomic Location for TIFAB Gene

Chromosome:
5
Start:
135,444,218 bp from pter
End:
135,452,399 bp from pter
Size:
8,182 bases
Orientation:
Minus strand

Genomic View for TIFAB Gene

Genes around TIFAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIFAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIFAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIFAB Gene

Proteins for TIFAB Gene

  • Protein details for TIFAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNK6-TIFAB_HUMAN
    Recommended name:
    TRAF-interacting protein with FHA domain-containing protein B
    Protein Accession:
    Q6ZNK6
    Secondary Accessions:
    • Q5H8A9

    Protein attributes for TIFAB Gene

    Size:
    161 amino acids
    Molecular mass:
    17888 Da
    Quaternary structure:
    • Interacts with TIFA.
    SequenceCaution:
    • Sequence=BAC85138.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TIFAB Gene

Post-translational modifications for TIFAB Gene

No Post-translational modifications

Other Protein References for TIFAB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIFAB Gene

Domains & Families for TIFAB Gene

Protein Domains for TIFAB Gene

Suggested Antigen Peptide Sequences for TIFAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIFAB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TIFAB Gene

Function for TIFAB Gene

Molecular function for TIFAB Gene

UniProtKB/Swiss-Prot Function:
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIFAB Gene

Localization for TIFAB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIFAB gene
Compartment Confidence
lysosome 1

Gene Ontology (GO) - Cellular Components for TIFAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TIFAB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TIFAB Gene

Pathways & Interactions for TIFAB Gene

SuperPathways for TIFAB Gene

No Data Available

Interacting Proteins for TIFAB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000440509%0d%0a9606.ENSP00000354911%0d%0a
Selected Interacting proteins: Q6ZNK6-TIFAB_HUMAN ENSP00000440509 for TIFAB Gene via IID STRING

Gene Ontology (GO) - Biological Process for TIFAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
GO:0007356 thorax and anterior abdomen determination IGI 23419067
GO:0021559 trigeminal nerve development IGI 23419067
GO:0021650 vestibulocochlear nerve formation IGI 23419067
GO:0030432 peristalsis IGI 23419067
genes like me logo Genes that share ontologies with TIFAB: view

No data available for Pathways by source and SIGNOR curated interactions for TIFAB Gene

Drugs & Compounds for TIFAB Gene

No Compound Related Data Available

Transcripts for TIFAB Gene

mRNA/cDNA for TIFAB Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIFAB Gene

TRAF-interacting protein with forkhead-associated domain, family member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIFAB Gene

No ASD Table

Relevant External Links for TIFAB Gene

GeneLoc Exon Structure for
TIFAB
ECgene alternative splicing isoforms for
TIFAB

Expression for TIFAB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIFAB Gene

Protein differential expression in normal tissues from HIPED for TIFAB Gene

This gene is overexpressed in Monocytes (41.3) and Tlymphocyte (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIFAB Gene



Protein tissue co-expression partners for TIFAB Gene

NURSA nuclear receptor signaling pathways regulating expression of TIFAB Gene:

TIFAB

SOURCE GeneReport for Unigene cluster for TIFAB Gene:

Hs.552091
genes like me logo Genes that share expression patterns with TIFAB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIFAB Gene

Orthologs for TIFAB Gene

This gene was present in the common ancestor of mammals.

Orthologs for TIFAB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIFAB 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia TIFAB 34 35
  • 84.6 (n)
rat
(Rattus norvegicus)
Mammalia Tifab 34
  • 81.86 (n)
cow
(Bos Taurus)
Mammalia TIFAB 34 35
  • 81.57 (n)
mouse
(Mus musculus)
Mammalia Tifab 34 16 35
  • 80.95 (n)
oppossum
(Monodelphis domestica)
Mammalia TIFAB 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIFAB 35
  • 47 (a)
OneToOne
Species where no ortholog for TIFAB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIFAB Gene

ENSEMBL:
Gene Tree for TIFAB (if available)
TreeFam:
Gene Tree for TIFAB (if available)

Paralogs for TIFAB Gene

No data available for Paralogs for TIFAB Gene

Variants for TIFAB Gene

Sequence variations from dbSNP and Humsavar for TIFAB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000088351 -- 135,452,813(+) CCTGC(A/C)GAACA upstream-variant-2KB
rs1000846504 -- 135,451,284(+) AATGT(C/T)CCTCC intron-variant
rs1001330660 -- 135,450,704(+) CATCA(C/T)CTTCA intron-variant
rs1001431619 -- 135,450,536(+) GAAAG(A/G)CTGCC intron-variant
rs1002032453 -- 135,449,350(+) GGGGG(G/T)TCCCT utr-variant-3-prime

Variation tolerance for TIFAB Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIFAB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIFAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIFAB Gene

Disorders for TIFAB Gene

Relevant External Links for TIFAB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIFAB

No disorders were found for TIFAB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIFAB Gene

Publications for TIFAB Gene

  1. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PMID: 15047173) Matsumura T. … Inoue J. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. (PMID: 26458771) Varney M.E. … Starczynowski D.T. (J. Exp. Med. 2015) 3 64
  4. A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]. (PMID: 23419067) SchrAPder J.C. … Bartsch O. (Behav Brain Funct 2013) 3 64
  5. TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions. (PMID: 19470519) Matsumura T. … Inoue J. (J. Biochem. 2009) 22 64

Products for TIFAB Gene

Sources for TIFAB Gene

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