TIFAB Gene
protein-coding GIFtS: 33
GCID: GC05M134813
|
|
TRAF-interacting protein with forkhead-associated domain,...
| |
Aliases
for TIFAB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TRAF-Interacting Protein With Forkhead-Associated Domain, Family MemberB1 2 | | TIFA-Like Protein2 3 | | TIFA-Related Protein TIFAB2 | | TRAF-Interacting Protein With FHA Domain-Containing Protein B2 |
Export aliases for TIFAB gene to outside databasesPrevious GC identifers: GC05U900526 GC05M129972 |
Summaries
for TIFAB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TIFAB:
TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011)(Matsumura et al., 2004 (PubMed 15047173)).(supplied by OMIM, Mar 2009)
UniProtKB/Swiss-Prot: TIFAB_HUMAN, Q6ZNK6Function: Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA
|
Genomic Views
for TIFAB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TIFAB gene promoter:
SRF TBP RREB-1 Brachyury SRF (504 AA) POU3F1 AP-4 AREB6 IRF-2 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIFAB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIFAB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.1TIFAB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M134813: view genomic region
(about GC identifiers)
Start:
|
134,779,908 bp from pter |
End:
|
134,788,089 bp from pter |
Size:
|
8,182 bases |
Orientation:
|
minus strand |
|
Proteins
for TIFAB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIFAB_HUMAN, Q6ZNK6 (See
protein sequence)Recommended Name: TRAF-interacting protein with FHA domain-containing protein B Size: 161 amino acids; 17888 Da
Subunit: Interacts with TIFA
Sequence caution: Sequence=BAC85138.1; Type=Erroneous initiation;
Secondary accessions: Q5H8A9Explore the universe of human proteins at neXtProt for TIFAB: NX_Q6ZNK6
TIFAB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092691.1
ENSEMBL proteins: ENSP00000440509
Human Recombinant Protein Products for TIFAB:
TIFAB Antibody Products:
Assay Products for TIFAB: |
Protein
Domains /
Families
for TIFAB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIFAB for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZNK6ProtoNet protein and cluster: Q6ZNK6 UniProtKB/Swiss-Prot: TIFAB_HUMAN, Q6ZNK6Similarity: Contains 1 FHA domain |
Function
for TIFAB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TIFAB_HUMAN, Q6ZNK6Function: Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFAAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIFAB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIFAB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TIFAB (NM_001099221) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIFAB | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIFAB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFAB |
|
Pathways & Interactions
for TIFAB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIFAB
1 Interacting protein for TIFAB (Q6ZNK63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TIFAB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TIFAB
Search CenterWatch for drugs/clinical trials and news about TIFAB
|
Transcripts
for TIFAB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TIFAB gene: NM_001099221.1 Unigene Cluster for TIFAB: TRAF-interacting protein with forkhead-associated domain, family member B Hs.552091 [show with all ESTs]Unigene Representative Sequence: NM_0010992211 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000537858(uc003law.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIFAB (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIFAB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TIFAB (NM_001099221) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIFAB | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIFAB |
Additional cDNA sequence: AB161513.1 1 DOTS entry: DT.40118818
GeneLoc Exon Structure
|
Expression
for TIFAB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIFAB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGCCCTTC
About this image
See TIFAB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIFAB
SOURCE GeneReport for Unigene cluster: Hs.552091
SABiosciences Custom PCR Arrays for TIFAB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIFAB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIFAB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIFAB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIFAB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFAB |
Orthologs
for TIFAB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for TIFAB gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for TIFAB (if available)
TreeFam Gene Tree for TIFAB (if available) |
Paralogs
for TIFAB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TIFAB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TIFAB (134779908 - 134788089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIFAB: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TIFAB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TIFAB for disorders About MalaCards
TIFAB for disorders About GeneDecksing
OMIM gene information: 612663
OMIM disorders: --
Export disorders for TIFAB gene to outside databases
|
Publications
for TIFAB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIFAB gene integrated from 9 sources:
(articles sorted by number of sources associating them with TIFAB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PubMed id 15047173)1, 2, 3, 9 Matsumura T....Inoue J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- TRAF-interacting protein with a forkhead-associated d omain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions . (PubMed id 19470519)9 Matsumura T....Inoue J. (2009)
|
External Searches for TIFAB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TIFAB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIFAB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIFAB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TIFAB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TIFAB gene:
Search GeneIP for patents involving TIFAB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIFAB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TIFAB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIFAB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIFAB | | | OriGene Protein Over-expression Lysate for TIFAB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TIFAB | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIFAB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIFAB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TIFAB | | OriGene Custom Protein Services for TIFAB | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIFAB | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIFAB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIFAB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIFAB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIFAB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIFAB |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TIFAB |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFAB |
|  |  |  |  | | | | ThermoFisher Antibodies for TIFAB |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TIFAB |
| |  | |
|
|
|
