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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIFA Gene

protein-coding GIFtS: 52
GCID: GC04M113196

TRAF-interacting protein with forkhead-associated domain

Explore 2 diseases affiliated with
TIFA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TRAF-Interacting Protein With Forkhead-Associated Domain¹ ²		TRAF2-Binding Protein² ³
T2BP¹ ² ³		MGC20791¹
T6BP¹ ²		TRAF-Interacting Protein With A Forkhead-Associated Domain²
TIFAA¹ ²		TRAF-Interacting Protein With FHA Domain-Containing Protein A²
Putative MAPK-Activating Protein PM14² ³		TRAF2 Binding Protein²
Putative NF-Kappa-B-Activating Protein 20² ³		TRAF6 Binding Protein²

External Ids:	HGNC: 19075¹	Entrez Gene: 92610²	Ensembl: ENSG00000145365⁷	OMIM: 609028⁵	UniProtKB: Q96CG3³

Export aliases for TIFA gene to outside databases

Previous GC identifers: GC04M113555 GC04M113416 GC04M108928

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TIFA_HUMAN, Q96CG3

Function: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the

downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6,

which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIFA gene promoter:
AP-2rep HOXA3 FOXO3 Cdc5 Ik-3 FOXO3b SRY STAT3 IRF-7A FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIFA promoter sequence

Search SABiosciences Chromatin IP Primers for TIFA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIFA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25

TIFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIFA gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M113196: view genomic region (about GC identifiers)

Start:	113,196,782 bp from pter	End:	113,207,059 bp from pter
Size:	10,278 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIFA_HUMAN, Q96CG3 (See protein sequence)

Recommended Name: TRAF-interacting protein with FHA domain-containing protein A

Size: 184 amino acids; 21445 Da

Subunit: Homotrimer. Interacts with IRAK1, TIFAB, ZCCHC11, TRAF2 and TRAF6. Binding to TIFAB inhibits TRAF6 activation

possibly by inducing a conformational change in TIFA. Binding to ZCCHC11 suppresses the TRAF6-dependent activation of

NF-kappa-B

Explore the universe of human proteins at neXtProt for TIFA: NX_Q96CG3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96CG3

TIFA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_443096.1

ENSEMBL proteins:

ENSP00000354911 ENSP00000424231

Human Recombinant Protein Products for TIFA:

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TIFA Antibody Products:

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Assay Products for TIFA:

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	Uscn ELISAs and CLIAs for TIFA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIFA for domains About GeneDecksing

1 InterPro domain/family:

IPR000253 FHA_dom

Graphical View of Domain Structure for InterPro Entry Q96CG3

ProtoNet protein and cluster: Q96CG3

1 Blocks protein family: IPB000253 Forkhead-associated (FHA)

UniProtKB/Swiss-Prot: TIFA_HUMAN, Q96CG3

Similarity: Contains 1 FHA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TIFA_HUMAN, Q96CG3

Function: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the

downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6,

which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16643855

TIFA for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for TIFA:

Decreased POU5F1-GFP protein e

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TIFA

miRNA Products:		OriGene 3'-UTR Clone: TIFA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIFA
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TIFA:
		hsa-miR-33a* hsa-miR-125a-3p hsa-miR-215 hsa-miR-192 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: TIFA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIFA (see all 4) OriGene shRNA RFP: TIFA OriGene siRNA: TIFA
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TIFA

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TIFA
			Sirion Biotech Customized adenovirus for overexpression of TIFA Sirion Biotech Customized adenovirus for potent knockdown of TIFA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIFA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIFA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TIFA (NM_052864)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TIFA
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		Sirion Biotech Customized stable knockdown cell line services for TIFA Sirion Biotech Customized inducible knockdown cell line services for TIFA Sirion Biotech Customized stable overexpressing cell line services for TIFA Sirion Biotech Customized inducible overexpressing cell line services for TIFA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

1 BioSystems Pathway for TIFA

TNF-alpha/NF-kB Signaling Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TIFA

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/22 Interacting proteins for TIFA (Q96CG3^{1, 2, 3} ENSP00000354911⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-67122 I2D: score=5 STRING: ENSP00000263925
SDCBP2	Q9H190²^,³, ENSP00000342935⁴	MINT-66594 I2D: score=5 STRING: ENSP00000342935
TRAF2	Q12933²^,³, ENSP00000247668⁴	MINT-50381 MINT-50380 I2D: score=6 STRING: ENSP00000247668
NIF3L1	Q9GZT8²^,³, ENSP00000386394⁴	MINT-66957 I2D: score=5 STRING: ENSP00000386394
NUDT18	Q6ZVK8²^,³, ENSP00000307852⁴	MINT-66371 I2D: score=5 STRING: ENSP00000307852

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007249	I-kappaB kinase/NF-kappaB cascade	IEA	--

TIFA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIFA
Search CenterWatch for drugs/clinical trials and news about TIFA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TIFA gene:

NM_052864.2

Unigene Cluster for TIFA:

TRAF-interacting protein with forkhead-associated domain

Hs.310640 [show with all ESTs]

Unigene Representative Sequence: NM_052864

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361717(uc003ial.3) ENST00000500655

miRNA Products:		OriGene 3'-UTR Clone: TIFA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIFA
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TIFA:
		hsa-miR-33a* hsa-miR-125a-3p hsa-miR-215 hsa-miR-192 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: TIFA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIFA (see all 4) OriGene shRNA RFP: TIFA OriGene siRNA: TIFA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIFA
		Sirion Biotech Custom design and validation of potent shRNA sequences against TIFA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIFA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIFA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TIFA (NM_052864)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIFA Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIFA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIFA

Additional cDNA sequence:

AB062110.1 AB097011.1 AB097038.1 AK292900.1 BC008294.1 BC014259.2

2 DOTS entries:

DT.454574 DT.95269001

24/125 AceView cDNA sequences (see all 125):

AA830457 AA805515 BQ011608 CR599623 AI337865 BU687073 BX089515 AI915509

BM718895 CA772080 CR623539 AB097038 BM680758 Z35722 AA769537 BX100167

AI188439 AI147211 BU625851 AA814954 AB097011 BG236358 BM680110 BF002808

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIFA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACATAATAA

About this image

TIFA expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Brain

Gut Tube

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TIFA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIFA

SOURCE GeneReport for Unigene cluster: Hs.310640

SABiosciences Custom PCR Arrays for TIFA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIFA Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIFA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TIFA gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tifa^{1 , 5}	TRAF-interacting protein with forkhead-associated domain^{1, 5}	82.42(n)¹ 77.47(a)¹		3 (56.54 cM)⁵ 211550¹ NM_145133.3¹ NP_660115.1¹ 127789872⁵
chicken (Gallus gallus)	Aves	TIFA¹	TRAF-interacting protein with forkhead-associated domain	65.04(n) 54.89(a)		422692 XM_420645.3 XP_420645.1
lizard (Anolis carolinensis)	Reptilia	TIFA⁶	--	56(a)	1 ↔ 1	5(143157738-143158271)
zebrafish (Danio rerio)	Actinopterygii	AL928799.1⁶	--	31(a)	1 ↔ 1	7(23956440-23957021)

ENSEMBL Gene Tree for TIFA (if available)
TreeFam Gene Tree for TIFA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191342216^1,2		--	113196288(+)	`TCTATC/GCACAT`	1	--	ds500¹		0	--	--	--	--
rs34635660^1,2	C,F	--	113196318(+)	`CATTAC/TATAAT`	1	--	ds500¹		10		NA WA CSA EA	370
rs146261891^1,2		--	113196453(+)	`GGGAGA/CTACAG`	1	--	ds500¹		0	--	--	--	--
rs3822289^1,2	C,F,A,H	--	113196545(-)	`TTTCAC/TAGAAC`	1	--	ds500¹		34		EA NA NS WA CSA	4543
rs3733630^1,2	C,F,A,H	--	113196787(-)	`TTTTTG/ATTCTA`	1	--	ut3¹		10		NA WA CSA EA	373
rs75525116^1,2		--	113196799(+)	`TTTAAC/TATTTC`	1	--	ut3¹		0	--	--	--	--
rs149918979^1,2		--	113196842(+)	`ATTAGA/GAGAAA`	1	--	ut3¹		0	--	--	--	--
rs3202899^1,2	C,F,O,A,H	--	113196906(-)	`TATTGG/AATCCA`	1	--	ut3¹ ese³		24		EA MN NS NA WA CSA	3269
rs149162436^1,2		--	113197063(+)	`AGAACA/GCCTTT`	1	--	ut3¹		0	--	--	--	--
rs182118990^1,2		--	113197116(+)	`TGGCTA/GTAAAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TIFA (113196782 - 113207059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIFA: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIFA

DNA2.0 Custom Variant and Variant Library Synthesis for TIFA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TIFA for disorders           About GeneDecksing

OMIM gene information: 609028    OMIM disorders: --

2 diseases for TIFA:    About MalaCards

alcohol dependence alcoholism

Human Genome Epidemiology (HuGE) Navigator: TIFA (10 documents)

Export disorders for TIFA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TIFA gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with TIFA)

Utopia: connect your pdf to the dynamic
world of online information

TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. (PubMed id 15492226)^{1, 2, 9} Ea C.-K.... Chen Z.J. (2004)
A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. (PubMed id 16643855)^{1, 2} Minoda Y.... Yoshimura A. (2006)
TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PubMed id 15047173)^{1, 2} Matsumura T....Inoue J. (2004)
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)^{1, 2} Matsuda A....Sugano S. (2003)
Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. (PubMed id 12566447)^{1, 2} Takatsuna H.... Inoue J. (2003)
Plastic surgical rehabilitation of the prison patient. (PubMed id 1179819)^{1, 3} Fisher J.C. and Edgerton M.P. (1975)
Intermolecular binding between TIFA-FHA and TIFA-pT me diates tumor necrosis factor alpha stimulation and NF-kB activation. (PubMed id 22566686)¹ Huang C.C....Tsai M.D. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 92610	HGNC: 19075	AceView: T2BP	Ensembl:ENSG00000145365	euGenes: HUgn92610
ECgene: TIFA	H-InvDB: TIFA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TIFA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TIFA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TIFA gene:
Search GeneIP for patents involving TIFA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for TIFA
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIFA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIFA
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	OriGene siRNA for TIFA		OriGene 3'-UTR Clone for TIFA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIFA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIFA
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	OriGene Custom Antibody Services for TIFA		OriGene Custom Protein Services for TIFA
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIFA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIFA
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIFA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIFA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIFA

	GenScript Custom Purified and Recombinant Proteins Services for TIFA		GenScript cDNA clones with any tag delivered in your preferred vector for TIFA
	GenScript Custom Assay Services for TIFA		GenScript Superior Antibodies for TIFA
	GenScript Custom overexpressing Cell Line Services for TIFA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in TIFA promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Recombinant Protein for TIFA

TIFA Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TIFA

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFA

	SwitchGear 3'UTR luciferase reporter plasmids for TIFA
	SwitchGear Promoter luciferase reporter plasmids for TIFA

ThermoFisher Antibodies for TIFA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIFA

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TIFA

Sirion Biotech Customized:

	stable knockdown cell line services for TIFA
	inducible knockdown cell line services for TIFA
	design and validation of potent shRNA sequences against TIFA
	adenovirus for potent knockdown of TIFA
	adenovirus for overexpression of TIFA
	stable overexpressing cell line services for TIFA
	inducible overexpressing cell line services for TIFA

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TIFA gene at Home site.

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TIFA Gene

TRAF-interacting protein with forkhead-associated domain

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TIFA Gene

TRAF-interacting protein with forkhead-associated domain

Aliasesfor TIFA gene

Summariesfor TIFA gene

Genomic Viewsfor TIFA gene

Proteinsfor TIFA gene

Protein Domains /Familiesfor TIFA gene

Functionfor TIFA gene

Pathways & Interactionsfor TIFA gene

Drugs & Compoundsfor TIFA gene

Transcriptsfor TIFA gene

Expression for TIFA gene

Orthologsfor TIFA gene

Paralogsfor TIFA gene

Genomic Variantsfor TIFA gene

Disorders / Diseasesfor TIFA gene

Publicationsfor TIFA gene

External Searches for TIFA gene

Genome Databases showing TIFA gene

Other Databases showing TIFA gene

Specialized Databases showing TIFA gene

Intellectual Propertyfor TIFA gene

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Aliases
for TIFA gene

Summaries
for TIFA gene

Genomic Views
for TIFA gene

Proteins
for TIFA gene

Protein Domains /
Families
for TIFA gene

Function
for TIFA gene

Pathways & Interactions
for TIFA gene

Drugs & Compounds
for TIFA gene

Transcripts
for TIFA gene

Expression
for TIFA gene

Orthologs
for TIFA gene

Paralogs
for TIFA gene

Genomic Variants
for TIFA gene

Disorders / Diseases
for TIFA gene

Publications
for TIFA gene

Intellectual Property
for TIFA gene

Products
for TIFA gene