Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TIFA Gene

protein-coding   GIFtS: 55
GCID: GC04M113196

TRAF-Interacting Protein With Forkhead-Associated Domain

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TRAF-Interacting Protein With Forkhead-Associated Domain1 2     TRAF2-Binding Protein2 3
TRAF2 Binding Protein1 2     T6BP2
TRAF6 Binding Protein1 2     TIFAA2
Putative MAPK-Activating Protein PM142 3     TRAF-Interacting Protein With A Forkhead-Associated Domain2
Putative NF-Kappa-B-Activating Protein 202 3     TRAF-Interacting Protein With FHA Domain-Containing Protein A2
T2BP2 3     

External Ids:    HGNC: 190751   Entrez Gene: 926102   Ensembl: ENSG000001453657   OMIM: 6090285   UniProtKB: Q96CG33   

Export aliases for TIFA gene to outside databases

Previous GC identifers: GC04M113555 GC04M113416 GC04M108928


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TIFA Gene:
TIFA (TRAF-interacting protein with forkhead-associated domain) is a protein-coding gene. Diseases associated with TIFA include alcohol dependence.

UniProtKB/Swiss-Prot: TIFA_HUMAN, Q96CG3
Function: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in
the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of
TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIFA gene promoter:
         AP-2rep   HOXA3   FOXO3   Cdc5   Ik-3   FOXO3b   SRY   STAT3   IRF-7A   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIFA promoter sequence
   Search Chromatin IP Primers for TIFA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

TIFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIFA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M113196:  view genomic region     (about GC identifiers)

Start:
113,195,698 bp from pter      End:
113,207,059 bp from pter
Size:
11,362 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TIFA_HUMAN, Q96CG3 (See protein sequence)
Recommended Name: TRAF-interacting protein with FHA domain-containing protein A  
Size: 184 amino acids; 21445 Da
Subunit: Homotrimer. Interacts with IRAK1, TIFAB, ZCCHC11, TRAF2 and TRAF6. Binding to TIFAB inhibits TRAF6
activation possibly by inducing a conformational change in TIFA. Binding to ZCCHC11 suppresses the
TRAF6-dependent activation of NF-kappa-B

Explore the universe of human proteins at neXtProt for TIFA: NX_Q96CG3

Explore proteomics data for TIFA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys48, Lys63, Lys108
  • Modification sites at PhosphoSitePlus

  • See TIFA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443096.1  
    ENSEMBL proteins: 
     ENSP00000354911   ENSP00000424231  

    TIFA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TIFA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TIFA
    GenScript Custom Purified and Recombinant Proteins Services for TIFA
    Novus Biologicals TIFA Proteins
    Novus Biologicals TIFA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TIFA
    Cloud-Clone Corp. Proteins for TIFA

    TIFA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TIFA
    Novus Biologicals TIFA Antibody
    Abcam antibodies for TIFA
    Cloud-Clone Corp. Antibodies for TIFA
    ThermoFisher Antibodies for TIFA
    LSBio Antibodies in human, mouse, rat for TIFA

    TIFA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TIFA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIFA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIFA
    Cloud-Clone Corp. CLIAs for TIFA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry Q96CG3

    ProtoNet protein and cluster: Q96CG3

    1 Blocks protein domain: IPB000253 Forkhead-associated (FHA)

    UniProtKB/Swiss-Prot: TIFA_HUMAN, Q96CG3
    Similarity: Contains 1 FHA domain


    TIFA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIFA_HUMAN, Q96CG3
    Function: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in
    the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of
    TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16643855
         
    TIFA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TIFA:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIFA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIFA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIFA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIFA

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIFA:
    hsa-mir-215-5p (MIRT024752), hsa-mir-192-5p (MIRT026675)

    Block miRNA regulation of human, mouse, rat TIFA using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TIFA:
    hsa-miR-33a* hsa-miR-125a-3p hsa-miR-215 hsa-miR-192 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTIFA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIFA
    Predesigned siRNA for gene silencing in human, mouse, rat TIFA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIFA

    Clone
    Products:
         
    OriGene clones in human, mouse for TIFA (see all 7)
    OriGene ORF clones in mouse, rat for TIFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIFA (NM_052864)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIFA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIFA
    Browse ESI BIO Cell Lines and PureStem Progenitors for TIFA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TIFA About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for TIFA
        TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIFA
    Interactions:

        GeneGlobe Interaction Network for TIFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for TIFA (Q96CG31, 2, 3 ENSP000003549114) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67122 I2D: score=5 STRING: ENSP00000263925
    SDCBP2Q9H1902, 3, ENSP000003429354MINT-66594 I2D: score=5 STRING: ENSP00000342935
    TRAF2Q129332, 3, ENSP000002476684MINT-50381 MINT-50380 I2D: score=6 STRING: ENSP00000247668
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-66957 I2D: score=5 STRING: ENSP00000386394
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-66371 I2D: score=5 STRING: ENSP00000307852
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007249I-kappaB kinase/NF-kappaB signaling IEA--

    TIFA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIFA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TIFA gene: 
    NM_052864.2  

    Unigene Cluster for TIFA:

    TRAF-interacting protein with forkhead-associated domain
    Hs.310640  [show with all ESTs]
    Unigene Representative Sequence: NM_052864
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361717(uc003ial.3) ENST00000500655
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TIFA using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TIFA:
    hsa-miR-33a* hsa-miR-125a-3p hsa-miR-215 hsa-miR-192 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTIFA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TIFA
    Predesigned siRNA for gene silencing in human, mouse, rat TIFA
    Clone
    Products:
         
    OriGene clones in human, mouse for TIFA (see all 7)
    OriGene ORF clones in mouse, rat for TIFA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIFA (NM_052864)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIFA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIFA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIFA
    OriGene qSTAR qPCR primer pairs in human, mouse for TIFA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIFA
      QuantiTect SYBR Green Assays in human, mouse, rat TIFA
      QuantiFast Probe-based Assays in human, mouse, rat TIFA

    Additional mRNA sequence: 

    AB062110.1 AB097011.1 AB097038.1 AK292900.1 BC008294.1 BC014259.2 

    2 DOTS entries:

    DT.454574  DT.95269001 

    Selected AceView cDNA sequences (see all 125):

    CR623539 BX100167 AA814954 AI188439 AB097011 CA772080 BM680758 AA805515 
    BC008294 BG236358 AA761315 AA857917 BM680110 BX089515 AA830457 BF002808 
    BQ011608 AB097038 AA809893 BU687073 AA766382 AI337865 CR599623 BM718895 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TIFA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATAATAA
    TIFA Expression
    About this image


    TIFA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Brain (Nervous System)
             Medulla Oblongata
    TIFA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIFA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.310640
        Custom PCR Arrays for TIFA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TIFA
    OriGene qSTAR qPCR primer pairs in human, mouse for TIFA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIFA
    QuantiTect SYBR Green Assays in human, mouse, rat TIFA
    QuantiFast Probe-based Assays in human, mouse, rat TIFA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TIFA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tifa1 , 5 TRAF-interacting protein with forkhead-associated domain1, 5 82.42(n)1
    77.47(a)1
      3 (56.54 cM)5
    2115501  NM_145133.31  NP_660115.11 
     1277898725 
    chicken
    (Gallus gallus)
    Aves TIFA1 TRAF-interacting protein with forkhead-associated domain 65.04(n)
    54.89(a)
      422692  XM_420645.4  XP_420645.2 
    lizard
    (Anolis carolinensis)
    Reptilia TIFA6
    TRAF-interacting protein with forkhead-associated ...
    56(a)
    1 ↔ 1
    5(143157738-143158271)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tifa1 TRAF-interacting protein with forkhead-associated domain 54.12(n)
    48.24(a)
      100216213  NM_001142181.1  NP_001135653.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5605481 TRAF-interacting protein with FHA domain-containing more 50.12(n)
    35.46(a)
      560548  XM_005172311.1  XP_005172368.1 


    ENSEMBL Gene Tree for TIFA (if available)
    TreeFam Gene Tree for TIFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TIFA (see all 277)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913422161,2
    --113196288(+) TCTATC/GCACAT 1 -- ds50010--------
    rs346356601,2
    C,F--113196318(+) CATTAC/TATAAT 1 -- ds500110Minor allele frequency- T:0.27NA WA CSA EA 370
    rs1462618911,2
    --113196453(+) GGGAGA/CTACAG 1 -- ds50010--------
    rs1117621201,2
    C--113196480(+) TATGCC/ATTGAG 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs38222891,2
    C,F,A,H--113196545(-) TTTCAC/TAGAAC 1 -- ds500134Minor allele frequency- T:0.25EA NA NS WA CSA 4543
    rs37336301,2
    C,F,A,H--113196787(-) TTTTTG/ATTCTA 1 -- ut3110Minor allele frequency- A:0.25NA WA CSA EA 373
    rs755251161,2
    --113196799(+) TTTAAC/TATTTC 1 -- ut310--------
    rs1499189791,2
    --113196842(+) ATTAGA/GAGAAA 1 -- ut310--------
    rs32028991,2
    C,F,O,A,H--113196906(-) TATTGG/AATCCA 1 -- ut31 ese324Minor allele frequency- A:0.26EA MN NS NA WA CSA 3269
    rs1491624361,2
    C--113197063(+) AGAACA/GCCTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TIFA (113195698 - 113207059 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TIFA: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIFA
    DNA2.0 Custom Variant and Variant Library Synthesis for TIFA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609028    OMIM disorders: --

    1 disease for TIFA:    
    About MalaCards
    alcohol dependence


    TIFA for disorders           About GeneDecksing

    Genetic Association Database (GAD): TIFA
    Human Genome Epidemiology (HuGE) Navigator: TIFA (10 documents)

    Export disorders for TIFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TIFA gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TIFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. (PubMed id 15492226)1, 2, 9 Ea C.-K.... Chen Z.J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. (PubMed id 16643855)1, 2 Minoda Y.... Yoshimura A. (Biochem. Biophys. Res. Commun. 2006)
    4. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PubMed id 15047173)1, 2 Matsumura T....Inoue J. (Biochem. Biophys. Res. Commun. 2004)
    5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    6. Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. (PubMed id 12566447)1, 2 Takatsuna H.... Inoue J. (J. Biol. Chem. 2003)
    7. Plastic surgical rehabilitation of the prison patient. (PubMed id 1179819)1, 3 Fisher J.C. and Edgerton M.P. (Va Med Mon (1918) 1975)
    8. Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-I_B activation. (PubMed id 22566686)1 Huang C.C....Tsai M.D. (Mol. Cell. Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 92610 HGNC: 19075 AceView: T2BP Ensembl:ENSG00000145365 euGenes: HUgn92610
    ECgene: TIFA H-InvDB: TIFA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TIFA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TIFA gene:
    Search GeneIP for patents involving TIFA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TIFA  
     OriGene qPCR primer pairs and template standards for TIFA   OriGene Protein Over-expression Lysate for TIFA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TIFA  
     OriGene qSTAR qPCR primer pairs in human, mouse for TIFA   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TIFA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TIFA   OriGene Custom Protein Services for TIFA  

     
     
     Block miRNA regulation of human, mouse, rat TIFA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TIFA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIFA Predesigned siRNA for gene silencing in human, mouse, rat TIFA
     QuantiFast Probe-based Assays in human, mouse, rat TIFA QuantiTect SYBR Green Assays in human, mouse, rat TIFA
     Custom PCR Arrays for TIFA Search Chromatin IP Primers for TIFA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIFA  GeneGlobe Interaction Network for TIFA
     Regulatory tfbs in TIFA promoter
     GenScript Custom Purified and Recombinant Proteins Services for TIFA GenScript cDNA clones with any tag delivered in your preferred vector for TIFA
     GenScript Custom Assay Services for TIFA GenScript Custom overexpressing Cell Line Services for TIFA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TIFA
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TIFA antibodies
     TIFA proteins
     TIFA lysates
     Antibodies for TIFA
     See all of Abcam's Antibodies, Kits and Proteins for TIFA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TIFA
     Proteins for TIFA
     Antibodies for TIFA
     ELISAs for TIFA
     CLIAs for TIFA



     Browse ESI BIO Cell Lines and PureStem Progenitors for TIFA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIFA
     SwitchGear 3'UTR luciferase reporter plasmids for TIFA
     SwitchGear Promoter luciferase reporter plasmids for TIFA
     ThermoFisher Antibodies for TIFA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIFA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIFA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIFA
     LSBio Antibodies in human, mouse, rat for TIFA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TIFA gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4