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Aliases for TIFA Gene

Aliases for TIFA Gene

  • TRAF-Interacting Protein With Forkhead-Associated Domain 2 3
  • Putative NF-Kappa-B-Activating Protein 20 3 4
  • Putative MAPK-Activating Protein PM14 3 4
  • TRAF2 Binding Protein 2 3
  • TRAF6 Binding Protein 2 3
  • TRAF2-Binding Protein 3 4
  • T2BP 3 4
  • TRAF-Interacting Protein With FHA Domain-Containing Protein A 3
  • TRAF-Interacting Protein With A Forkhead-Associated Domain 3
  • TIFAA 3
  • T6BP 3

External Ids for TIFA Gene

Summaries for TIFA Gene

GeneCards Summary for TIFA Gene

TIFA (TRAF-Interacting Protein With Forkhead-Associated Domain) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway.

UniProtKB/Swiss-Prot for TIFA Gene

  • Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFA Gene

Genomics for TIFA Gene

Genomic Location for TIFA Gene

Start:
112,274,542 bp from pter
End:
112,285,903 bp from pter
Size:
11,362 bases
Orientation:
Minus strand

Genomic View for TIFA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIFA Gene

Regulatory Elements for TIFA Gene

Proteins for TIFA Gene

  • Protein details for TIFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CG3-TIFA_HUMAN
    Recommended name:
    TRAF-interacting protein with FHA domain-containing protein A
    Protein Accession:
    Q96CG3
    Secondary Accessions:

    Protein attributes for TIFA Gene

    Size:
    184 amino acids
    Molecular mass:
    21445 Da
    Quaternary structure:
    • Homotrimer. Interacts with IRAK1, TIFAB, ZCCHC11, TRAF2 and TRAF6. Binding to TIFAB inhibits TRAF6 activation possibly by inducing a conformational change in TIFA. Binding to ZCCHC11 suppresses the TRAF6-dependent activation of NF-kappa-B.

neXtProt entry for TIFA Gene

Proteomics data for TIFA Gene at MOPED

Post-translational modifications for TIFA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48, Lys63, and Lys108

Other Protein References for TIFA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIFA Gene

Domains for TIFA Gene

Protein Domains for TIFA Gene

UniProtKB/Swiss-Prot:

TIFA_HUMAN
Domain:
  • Contains 1 FHA domain.:
    • Q96CG3
genes like me logo Genes that share domains with TIFA: view

No data available for Gene Families for TIFA Gene

Function for TIFA Gene

Molecular function for TIFA Gene

UniProtKB/Swiss-Prot Function: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.

Gene Ontology (GO) - Molecular Function for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11798190
genes like me logo Genes that share ontologies with TIFA: view

Phenotypes for TIFA Gene

genes like me logo Genes that share phenotypes with TIFA: view

miRNA for TIFA Gene

miRTarBase miRNAs that target TIFA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIFA Gene

Localization for TIFA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIFA Gene COMPARTMENTS Subcellular localization image for TIFA gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TIFA Gene

Pathways for TIFA Gene

genes like me logo Genes that share pathways with TIFA: view

Pathways by source for TIFA Gene

1 BioSystems pathway for TIFA Gene

Gene Ontology (GO) - Biological Process for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with TIFA: view

Transcripts for TIFA Gene

mRNA/cDNA for TIFA Gene

Unigene Clusters for TIFA Gene

TRAF-interacting protein with forkhead-associated domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIFA Gene

No ASD Table

Relevant External Links for TIFA Gene

GeneLoc Exon Structure for
TIFA
ECgene alternative splicing isoforms for
TIFA

Expression for TIFA Gene

mRNA expression in normal human tissues for TIFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIFA Gene

SOURCE GeneReport for Unigene cluster for TIFA Gene Hs.310640

genes like me logo Genes that share expressions with TIFA: view

Orthologs for TIFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIFA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIFA 36
  • 99.46 (n)
  • 98.91 (a)
TIFA 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIFA 36
  • 82.51 (n)
  • 75.96 (a)
TIFA 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIFA 36
  • 87.8 (n)
  • 87.43 (a)
TIFA 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tifa 36
  • 82.42 (n)
  • 77.47 (a)
Tifa 16
Tifa 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 59 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TIFA 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tifa 36
  • 84.15 (n)
  • 79.23 (a)
chicken
(Gallus gallus)
Aves TIFA 36
  • 65.04 (n)
  • 54.89 (a)
TIFA 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIFA 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tifa 36
  • 54.12 (n)
  • 48.24 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560548 36
  • 50.12 (n)
  • 35.46 (a)
TIFA 37
  • 31 (a)
OneToOne
Species with no ortholog for TIFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIFA Gene

ENSEMBL:
Gene Tree for TIFA (if available)
TreeFam:
Gene Tree for TIFA (if available)

Paralogs for TIFA Gene

No data available for Paralogs for TIFA Gene

Variants for TIFA Gene

Sequence variations from dbSNP and Humsavar for TIFA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs701758 -- 112,277,649(+) GAGCA(C/G)TTAAA utr-variant-3-prime
rs701759 -- 112,277,919(+) AGCGA(A/G)TAAGT synonymous-codon, reference
rs909031 -- 112,284,984(+) TCTCC(C/G)ACTCT intron-variant
rs909032 -- 112,285,265(+) GCCGT(A/G)GCAGT intron-variant
rs955361 -- 112,277,390(+) CACTA(G/T)CCTAG utr-variant-3-prime

Relevant External Links for TIFA Gene

HapMap Linkage Disequilibrium report
TIFA

No data available for Structural Variations from Database of Genomic Variants (DGV) for TIFA Gene

Disorders for TIFA Gene

Relevant External Links for TIFA

Genetic Association Database (GAD)
TIFA
Human Genome Epidemiology (HuGE) Navigator
TIFA
genes like me logo Genes that share disorders with TIFA: view

No data available for UniProtKB/Swiss-Prot for TIFA Gene

Publications for TIFA Gene

  1. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. (PMID: 15492226) Ea C.-K. … Chen Z.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  2. Plastic surgical rehabilitation of the prison patient. (PMID: 1179819) Fisher J.C. … Edgerton M.P. (Va Med Mon (1918) 1975) 2 3
  3. Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. (PMID: 12566447) Takatsuna H. … Inoue J. (J. Biol. Chem. 2003) 3 4
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  5. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PMID: 15047173) Matsumura T. … Inoue J. (Biochem. Biophys. Res. Commun. 2004) 3 4

Products for TIFA Gene

Sources for TIFA Gene

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