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Aliases for TIFA Gene

Aliases for TIFA Gene

  • TRAF Interacting Protein With Forkhead Associated Domain 2 3 5
  • Putative NF-Kappa-B-Activating Protein 20 3 4
  • Putative MAPK-Activating Protein PM14 3 4
  • TRAF2 Binding Protein 2 3
  • TRAF6 Binding Protein 2 3
  • T2BP 3 4
  • TRAF-Interacting Protein With FHA Domain-Containing Protein A 3
  • TRAF-Interacting Protein With A Forkhead-Associated Domain 3
  • TRAF-Interacting Protein With Forkhead-Associated Domain 2
  • TRAF2-Binding Protein 4
  • TIFAA 3
  • T6BP 3

External Ids for TIFA Gene

Previous GeneCards Identifiers for TIFA Gene

  • GC04M113555
  • GC04M113416
  • GC04M113196
  • GC04M108928

Summaries for TIFA Gene

GeneCards Summary for TIFA Gene

TIFA (TRAF Interacting Protein With Forkhead Associated Domain) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway.

UniProtKB/Swiss-Prot for TIFA Gene

  • Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFA Gene

Genomics for TIFA Gene

Regulatory Elements for TIFA Gene

Enhancers for TIFA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F112282 1.4 FANTOM5 ENCODE 26.6 -0.5 -451 7.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A GLI4 DMAP1 ZNF2 YY1 GLIS2 TIFA C4orf32 AP1AR RTEL1P1 LARP7 ALPK1 ZGRF1 GC04P112321
GH04F112279 1.4 FANTOM5 Ensembl ENCODE 20.7 +5.8 5803 2.2 PKNOX1 TBL1XR1 BMI1 CREM JUNB CEBPB TBX21 IKZF1 CEBPA NBN TIFA C4orf32 ENSG00000272567 ALPK1
GH04F112230 1.1 ENCODE 17.1 +53.9 53868 3.7 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 TIFA AP1AR LOC105377371
GH04F112312 1.3 FANTOM5 Ensembl ENCODE 12.7 -27.0 -26962 1.9 HDGF TBP PKNOX1 POLR2A GATA2 CBX5 NCOR1 EED ETV6 MTA2 TIFA AP1AR ALPK1 LARP7 GC04P112321
GH04F112259 0.9 FANTOM5 17.6 +25.9 25897 0.3 ELF3 RAD21 ZSCAN9 ZNF48 RARA THAP11 MIXL1 HMG20B KLF11 MXD4 TIFA C4orf32 NEUROG2 ENSG00000249509 ZGRF1 AP1AR ENSG00000272567 LOC105377371
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIFA on UCSC Golden Path with GeneCards custom track

Promoters for TIFA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001247536 903 3201 HDGF WRNIP1 ARID4B SIN3A GLI4 DMAP1 ZNF2 YY1 GLIS2 ZNF143

Genomic Location for TIFA Gene

Chromosome:
4
Start:
112,274,542 bp from pter
End:
112,285,903 bp from pter
Size:
11,362 bases
Orientation:
Minus strand

Genomic View for TIFA Gene

Genes around TIFA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIFA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIFA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIFA Gene

Proteins for TIFA Gene

  • Protein details for TIFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CG3-TIFA_HUMAN
    Recommended name:
    TRAF-interacting protein with FHA domain-containing protein A
    Protein Accession:
    Q96CG3

    Protein attributes for TIFA Gene

    Size:
    184 amino acids
    Molecular mass:
    21445 Da
    Quaternary structure:
    • Homotrimer. Interacts with IRAK1, TIFAB, ZCCHC11, TRAF2 and TRAF6. Binding to TIFAB inhibits TRAF6 activation possibly by inducing a conformational change in TIFA. Binding to ZCCHC11 suppresses the TRAF6-dependent activation of NF-kappa-B.

    Three dimensional structures from OCA and Proteopedia for TIFA Gene

neXtProt entry for TIFA Gene

Post-translational modifications for TIFA Gene

  • Ubiquitination at Lys 48, Lys 63, and Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for TIFA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIFA Gene

Domains & Families for TIFA Gene

Protein Domains for TIFA Gene

Suggested Antigen Peptide Sequences for TIFA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CG3

UniProtKB/Swiss-Prot:

TIFA_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with TIFA: view

No data available for Gene Families for TIFA Gene

Function for TIFA Gene

Molecular function for TIFA Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.

Gene Ontology (GO) - Molecular Function for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11798190
genes like me logo Genes that share ontologies with TIFA: view
genes like me logo Genes that share phenotypes with TIFA: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIFA Gene

Localization for TIFA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIFA gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TIFA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TIFA Gene

Pathways & Interactions for TIFA Gene

genes like me logo Genes that share pathways with TIFA: view

Pathways by source for TIFA Gene

1 BioSystems pathway for TIFA Gene

Gene Ontology (GO) - Biological Process for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with TIFA: view

No data available for SIGNOR curated interactions for TIFA Gene

Transcripts for TIFA Gene

mRNA/cDNA for TIFA Gene

Unigene Clusters for TIFA Gene

TRAF-interacting protein with forkhead-associated domain:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIFA Gene

No ASD Table

Relevant External Links for TIFA Gene

GeneLoc Exon Structure for
TIFA
ECgene alternative splicing isoforms for
TIFA

Expression for TIFA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIFA Gene

This gene is overexpressed in Spleen (22.9), Blymphocyte (11.5), Fetal gut (10.1), Salivary gland (9.1), Skin (8.7), and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIFA Gene



NURSA nuclear receptor signaling pathways regulating expression of TIFA Gene:

TIFA

SOURCE GeneReport for Unigene cluster for TIFA Gene:

Hs.310640
genes like me logo Genes that share expression patterns with TIFA: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TIFA Gene

Orthologs for TIFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIFA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIFA 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia TIFA 34 35
  • 87.8 (n)
rat
(Rattus norvegicus)
Mammalia Tifa 34
  • 84.15 (n)
cow
(Bos Taurus)
Mammalia TIFA 34 35
  • 82.51 (n)
mouse
(Mus musculus)
Mammalia Tifa 34 16 35
  • 82.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIFA 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves TIFA 34 35
  • 65.04 (n)
lizard
(Anolis carolinensis)
Reptilia TIFA 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tifa 34
  • 54.12 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC560548 34
  • 50.12 (n)
TIFA 35
  • 31 (a)
OneToOne
Species where no ortholog for TIFA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIFA Gene

ENSEMBL:
Gene Tree for TIFA (if available)
TreeFam:
Gene Tree for TIFA (if available)

Paralogs for TIFA Gene

No data available for Paralogs for TIFA Gene

Variants for TIFA Gene

Sequence variations from dbSNP and Humsavar for TIFA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000620 -- 112,282,048(+) ctgat(A/G)ggagg intron-variant
rs10000700 -- 112,282,115(+) atcac(A/G)agatc intron-variant
rs10003654 -- 112,282,997(+) AACCT(A/G)CTTTT intron-variant
rs10008828 -- 112,283,940(+) TGTGA(C/T)ATCTG intron-variant
rs10026212 -- 112,282,958(+) TCACT(C/T)TTGTT intron-variant

Variation tolerance for TIFA Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIFA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIFA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIFA Gene

Disorders for TIFA Gene

Relevant External Links for TIFA

Genetic Association Database (GAD)
TIFA
Human Genome Epidemiology (HuGE) Navigator
TIFA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIFA

No disorders were found for TIFA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIFA Gene

Publications for TIFA Gene

  1. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. (PMID: 15492226) Ea C.-K. … Chen Z.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  3. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. (PMID: 16643855) Minoda Y. … Yoshimura A. (Biochem. Biophys. Res. Commun. 2006) 3 4 64
  4. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead- associated domain. (PMID: 15047173) Matsumura T. … Inoue J. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  5. Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. (PMID: 12566447) Takatsuna H. … Inoue J. (J. Biol. Chem. 2003) 3 4 64

Products for TIFA Gene

Sources for TIFA Gene

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