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Aliases for TIFA Gene

Aliases for TIFA Gene

  • TRAF-Interacting Protein With Forkhead-Associated Domain 2 3
  • Putative NF-Kappa-B-Activating Protein 20 3 4
  • Putative MAPK-Activating Protein PM14 3 4
  • TRAF2 Binding Protein 2 3
  • TRAF6 Binding Protein 2 3
  • TRAF2-Binding Protein 3 4
  • T2BP 3 4
  • TRAF-Interacting Protein With A Forkhead-Associated Domain 3
  • TIFAA 3
  • T6BP 3

External Ids for TIFA Gene

Previous GeneCards Identifiers for TIFA Gene

  • GC04M113555
  • GC04M113416
  • GC04M113196
  • GC04M108928

Summaries for TIFA Gene

GeneCards Summary for TIFA Gene

TIFA (TRAF-Interacting Protein With Forkhead-Associated Domain) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway.

UniProtKB/Swiss-Prot for TIFA Gene

  • Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFA Gene

Genomics for TIFA Gene

Regulatory Elements for TIFA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIFA Gene

Chromosome:
4
Start:
112,274,542 bp from pter
End:
112,285,903 bp from pter
Size:
11,362 bases
Orientation:
Minus strand

Genomic View for TIFA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TIFA Gene

Proteins for TIFA Gene

  • Protein details for TIFA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CG3-TIFA_HUMAN
    Recommended name:
    TRAF-interacting protein with FHA domain-containing protein A
    Protein Accession:
    Q96CG3

    Protein attributes for TIFA Gene

    Size:
    184 amino acids
    Molecular mass:
    21445 Da
    Quaternary structure:
    • Homotrimer. Interacts with IRAK1, TIFAB, ZCCHC11, TRAF2 and TRAF6. Binding to TIFAB inhibits TRAF6 activation possibly by inducing a conformational change in TIFA. Binding to ZCCHC11 suppresses the TRAF6-dependent activation of NF-kappa-B.

neXtProt entry for TIFA Gene

Proteomics data for TIFA Gene at MOPED

Post-translational modifications for TIFA Gene

  • Ubiquitination at Lys 48, Lys 63, and Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for TIFA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIFA Gene

Domains & Families for TIFA Gene

Protein Domains for TIFA Gene

Suggested Antigen Peptide Sequences for TIFA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CG3

UniProtKB/Swiss-Prot:

TIFA_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
genes like me logo Genes that share domains with TIFA: view

No data available for Gene Families for TIFA Gene

Function for TIFA Gene

Molecular function for TIFA Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.

Gene Ontology (GO) - Molecular Function for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11798190
genes like me logo Genes that share ontologies with TIFA: view
genes like me logo Genes that share phenotypes with TIFA: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIFA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TIFA Gene

Localization for TIFA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIFA Gene COMPARTMENTS Subcellular localization image for TIFA gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TIFA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TIFA Gene

Pathways & Interactions for TIFA Gene

genes like me logo Genes that share pathways with TIFA: view

Pathways by source for TIFA Gene

1 BioSystems pathway for TIFA Gene

Gene Ontology (GO) - Biological Process for TIFA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with TIFA: view

No data available for SIGNOR curated interactions for TIFA Gene

Drugs & Compounds for TIFA Gene

No Compound Related Data Available

Transcripts for TIFA Gene

mRNA/cDNA for TIFA Gene

Unigene Clusters for TIFA Gene

TRAF-interacting protein with forkhead-associated domain:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIFA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIFA Gene

No ASD Table

Relevant External Links for TIFA Gene

GeneLoc Exon Structure for
TIFA
ECgene alternative splicing isoforms for
TIFA

Expression for TIFA Gene

mRNA expression in normal human tissues for TIFA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIFA Gene

This gene is overexpressed in Spleen (22.9), Blymphocyte (11.5), Fetal gut (10.1), Salivary gland (9.1), Skin (8.7), and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIFA Gene



SOURCE GeneReport for Unigene cluster for TIFA Gene Hs.310640

genes like me logo Genes that share expression patterns with TIFA: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TIFA Gene

Orthologs for TIFA Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIFA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIFA 35
  • 82.51 (n)
  • 75.96 (a)
TIFA 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIFA 35
  • 87.8 (n)
  • 87.43 (a)
TIFA 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tifa 35
  • 82.42 (n)
  • 77.47 (a)
Tifa 16
Tifa 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIFA 35
  • 99.46 (n)
  • 98.91 (a)
TIFA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tifa 35
  • 84.15 (n)
  • 79.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TIFA 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIFA 35
  • 65.04 (n)
  • 54.89 (a)
TIFA 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIFA 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tifa 35
  • 54.12 (n)
  • 48.24 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560548 35
  • 50.12 (n)
  • 35.46 (a)
TIFA 36
  • 31 (a)
OneToOne
Species with no ortholog for TIFA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIFA Gene

ENSEMBL:
Gene Tree for TIFA (if available)
TreeFam:
Gene Tree for TIFA (if available)

Paralogs for TIFA Gene

No data available for Paralogs for TIFA Gene

Variants for TIFA Gene

Sequence variations from dbSNP and Humsavar for TIFA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_051422 -

Variation tolerance for TIFA Gene

Residual Variation Intolerance Score: 75.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIFA Gene

HapMap Linkage Disequilibrium report
TIFA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIFA Gene

Disorders for TIFA Gene

Relevant External Links for TIFA

Genetic Association Database (GAD)
TIFA
Human Genome Epidemiology (HuGE) Navigator
TIFA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIFA
genes like me logo Genes that share disorders with TIFA: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIFA Gene

Publications for TIFA Gene

  1. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. (PMID: 15492226) Ea C.-K. … Chen Z.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 23 67
  2. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PMID: 12536145) Gurung R. … Mitchell C.A. (J. Biol. Chem. 2003) 23 67
  3. Plastic surgical rehabilitation of the prison patient. (PMID: 1179819) Fisher J.C. … Edgerton M.P. (Va Med Mon (1918) 1975) 2 67
  4. INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. (PMID: 26068852) Gaudet R.G. … Gray-Owen S.D. (Science 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for TIFA Gene

Sources for TIFA Gene

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