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Aliases for TIE1 Gene

Aliases for TIE1 Gene

  • Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1 2 3
  • Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1 2 3 5
  • Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1 2 3
  • EC 2.7.10.1 4 63
  • TIE 3 4
  • EC 2.7.10 63
  • JTK14 3

External Ids for TIE1 Gene

Previous HGNC Symbols for TIE1 Gene

  • TIE

Previous GeneCards Identifiers for TIE1 Gene

  • GC01P043437
  • GC01P043539
  • GC01P043766
  • GC01P041886

Summaries for TIE1 Gene

Entrez Gene Summary for TIE1 Gene

  • This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIE1 Gene

TIE1 (Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STYK1.

UniProtKB/Swiss-Prot for TIE1 Gene

  • Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIE1 Gene

Genomics for TIE1 Gene

Regulatory Elements for TIE1 Gene

Promoters for TIE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIE1 Gene

Chromosome:
1
Start:
43,300,895 bp from pter
End:
43,323,110 bp from pter
Size:
22,216 bases
Orientation:
Plus strand

Genomic View for TIE1 Gene

Genes around TIE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIE1 Gene

Proteins for TIE1 Gene

  • Protein details for TIE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35590-TIE1_HUMAN
    Recommended name:
    Tyrosine-protein kinase receptor Tie-1
    Protein Accession:
    P35590
    Secondary Accessions:
    • B5A949
    • B5A950

    Protein attributes for TIE1 Gene

    Size:
    1138 amino acids
    Molecular mass:
    125090 Da
    Quaternary structure:
    • Heterodimer with TEK/TIE2.

    Alternative splice isoforms for TIE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIE1 Gene

Proteomics data for TIE1 Gene at MOPED

Post-translational modifications for TIE1 Gene

  • Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • Glycosylation at Asn 83, Asn 161, Asn 503, Asn 596, and Asn 709
  • Modification sites at PhosphoSitePlus

Other Protein References for TIE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for TIE1 Gene

Graphical View of Domain Structure for InterPro Entry

P35590

UniProtKB/Swiss-Prot:

TIE1_HUMAN :
  • Contains 3 EGF-like domains.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Domain:
  • Contains 3 EGF-like domains.
  • Contains 3 fibronectin type-III domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
genes like me logo Genes that share domains with TIE1: view

Function for TIE1 Gene

Molecular function for TIE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Enzyme Numbers (IUBMB) for TIE1 Gene

Gene Ontology (GO) - Molecular Function for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with TIE1: view
genes like me logo Genes that share phenotypes with TIE1: view

Animal Models for TIE1 Gene

MGI Knock Outs for TIE1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TIE1 Gene

Localization for TIE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIE1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIE1 Gene COMPARTMENTS Subcellular localization image for TIE1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TIE1 Gene

Pathways & Interactions for TIE1 Gene

genes like me logo Genes that share pathways with TIE1: view

Pathways by source for TIE1 Gene

SIGNOR curated interactions for TIE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0007165 signal transduction TAS 1312667
GO:0007498 mesoderm development TAS 7596437
GO:0018108 peptidyl-tyrosine phosphorylation TAS 1312667
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with TIE1: view

Drugs & Compounds for TIE1 Gene

(3) Drugs for TIE1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for TIE1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TIE1: view

Transcripts for TIE1 Gene

Unigene Clusters for TIE1 Gene

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: -
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TIE1 Gene

GeneLoc Exon Structure for
TIE1
ECgene alternative splicing isoforms for
TIE1

Expression for TIE1 Gene

mRNA expression in normal human tissues for TIE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIE1 Gene

This gene is overexpressed in Plasma (53.8) and Bone (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIE1 Gene



SOURCE GeneReport for Unigene cluster for TIE1 Gene Hs.78824

mRNA Expression by UniProt/SwissProt for TIE1 Gene

P35590-TIE1_HUMAN
Tissue specificity: Specifically expressed in developing vascular endothelial cells.
genes like me logo Genes that share expression patterns with TIE1: view

Protein tissue co-expression partners for TIE1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TIE1 Gene

Orthologs for TIE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIE1 35
  • 89.9 (n)
  • 93.22 (a)
TIE1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIE1 35
  • 89.69 (n)
  • 93.5 (a)
TIE1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tie1 35
  • 87.76 (n)
  • 93.12 (a)
Tie1 16
Tie1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIE1 35
  • 99.56 (n)
  • 99.65 (a)
TIE1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tie1 35
  • 87.88 (n)
  • 92.69 (a)
oppossum
(Monodelphis domestica)
Mammalia TIE1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIE1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIE1 35
  • 68.52 (n)
  • 66.58 (a)
TIE1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIE1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tie1 35
  • 60.88 (n)
  • 62.28 (a)
zebrafish
(Danio rerio)
Actinopterygii tie1 35
  • 59.45 (n)
  • 59.3 (a)
tie1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tie 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ver-3 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TIE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIE1 Gene

ENSEMBL:
Gene Tree for TIE1 (if available)
TreeFam:
Gene Tree for TIE1 (if available)

Paralogs for TIE1 Gene

Paralogs for TIE1 Gene

genes like me logo Genes that share paralogs with TIE1: view

Variants for TIE1 Gene

Sequence variations from dbSNP and Humsavar for TIE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs56302794 - 43,311,679(+) CCCCC(A/G)TGCCC nc-transcript-variant, reference, missense
rs35573981 - 43,321,681(+) GATTG(C/T)GCTAC nc-transcript-variant, reference, missense
rs34993202 - 43,321,696(+) AGGCC(A/G)CATGC nc-transcript-variant, reference, missense
rs8966 -- 43,322,939(-) AACTA(A/G)AAAAA nc-transcript-variant, utr-variant-3-prime
rs866332 -- 43,323,187(+) CCGGG(C/T)GTGGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TIE1 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV Loss 17160897
esv2747574 CNV Deletion 23290073

Variation tolerance for TIE1 Gene

Residual Variation Intolerance Score: 3.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIE1 Gene

HapMap Linkage Disequilibrium report
TIE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIE1 Gene

Disorders for TIE1 Gene

Relevant External Links for TIE1

Genetic Association Database (GAD)
TIE1
Human Genome Epidemiology (HuGE) Navigator
TIE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIE1

No disorders were found for TIE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIE1 Gene

Publications for TIE1 Gene

  1. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. (PMID: 1312667) Partanen J. … Alitalo K. (Mol. Cell. Biol. 1992) 2 3 4 67
  2. A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. (PMID: 19880500) Li K. … Ramchandran R. (Blood 2010) 3 23
  3. Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function. (PMID: 19236867) Chan B. … Sukhatme V.P. (FEBS Lett. 2009) 3 23
  4. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PMID: 18593464) Jin P. … Paleolog E.M. (Arthritis Res. Ther. 2008) 3 23
  5. The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta. (PMID: 18675456) Seval Y. … Demir R. (Placenta 2008) 3 23

Products for TIE1 Gene

Sources for TIE1 Gene

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