Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIE1 Gene

Aliases for TIE1 Gene

  • Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1 2 3
  • TIE 3 4 6
  • Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1 2 3
  • EC 4 63
  • Tyrosine-Protein Kinase Receptor Tie-1 3
  • EC 2.7.10 63
  • JTK14, 6
  • JTK14 3

External Ids for TIE1 Gene

Previous HGNC Symbols for TIE1 Gene

  • TIE

Previous GeneCards Identifiers for TIE1 Gene

  • GC01P043437
  • GC01P043539
  • GC01P043766
  • GC01P041886

Summaries for TIE1 Gene

Entrez Gene Summary for TIE1 Gene

  • This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIE1 Gene

TIE1 (Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1) is a Protein Coding gene. Diseases associated with TIE1 include cerebral arteriovenous malformation. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is STYK1.

UniProtKB/Swiss-Prot for TIE1 Gene

  • Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIE1 Gene

Genomics for TIE1 Gene

Regulatory Elements for TIE1 Gene

Genomic Location for TIE1 Gene

43,300,895 bp from pter
43,323,110 bp from pter
22,216 bases
Plus strand

Genomic View for TIE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIE1 Gene

Proteins for TIE1 Gene

  • Protein details for TIE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein kinase receptor Tie-1
    Protein Accession:
    Secondary Accessions:
    • B5A949
    • B5A950

    Protein attributes for TIE1 Gene

    1138 amino acids
    Molecular mass:
    125090 Da
    Quaternary structure:
    • Heterodimer with TEK/TIE2

    Alternative splice isoforms for TIE1 Gene


neXtProt entry for TIE1 Gene

Proteomics data for TIE1 Gene at MOPED

Post-translational modifications for TIE1 Gene

  • Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • Glycosylation at Asn83, Asn161, Asn503, Asn596, and Asn709
  • Modification sites at PhosphoSitePlus

Other Protein References for TIE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TIE1 Gene

Gene Families for TIE1 Gene

  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Suggested Antigen Peptide Sequences for TIE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P35590
  • Contains 3 EGF-like domains.
  • Contains 3 fibronectin type-III domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
genes like me logo Genes that share domains with TIE1: view

Function for TIE1 Gene

Molecular function for TIE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Enzyme Numbers (IUBMB) for TIE1 Gene

Gene Ontology (GO) - Molecular Function for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 21982860
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TIE1: view
genes like me logo Genes that share phenotypes with TIE1: view

Animal Models for TIE1 Gene

MGI Knock Outs for TIE1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TIE1 Gene

Localization for TIE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIE1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TIE1 Gene COMPARTMENTS Subcellular localization image for TIE1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 1312667
genes like me logo Genes that share ontologies with TIE1: view

Pathways for TIE1 Gene

genes like me logo Genes that share pathways with TIE1: view

Pathways by source for TIE1 Gene

1 GeneGo (Thomson Reuters) pathway for TIE1 Gene
1 R&D Systems pathway for TIE1 Gene

Gene Ontology (GO) - Biological Process for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001568 blood vessel development --
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006468 protein phosphorylation --
genes like me logo Genes that share ontologies with TIE1: view

Compounds for TIE1 Gene

(2) HMDB Compounds for TIE1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(4) Novoseek inferred chemical compound relationships for TIE1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 72.9 47
vegf 71.7 43
nitric oxide 0 3
glucose 0 2
genes like me logo Genes that share compounds with TIE1: view

Transcripts for TIE1 Gene

Unigene Clusters for TIE1 Gene

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP4: - -
SP5: -
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -

Relevant External Links for TIE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIE1 Gene

mRNA expression in normal human tissues for TIE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIE1 Gene

SOURCE GeneReport for Unigene cluster for TIE1 Gene Hs.78824

mRNA Expression by UniProt/SwissProt for TIE1 Gene

Tissue specificity: Specifically expressed in developing vascular endothelial cells
genes like me logo Genes that share expressions with TIE1: view

No data available for mRNA differential expression in normal tissues for TIE1 Gene

Orthologs for TIE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIE1 35
  • 99.56 (n)
  • 99.65 (a)
TIE1 36
  • 100 (a)
(Bos Taurus)
Mammalia TIE1 35
  • 89.9 (n)
  • 93.22 (a)
TIE1 36
  • 93 (a)
(Canis familiaris)
Mammalia TIE1 35
  • 89.69 (n)
  • 93.5 (a)
TIE1 36
  • 93 (a)
(Mus musculus)
Mammalia Tie1 35
  • 87.76 (n)
  • 93.12 (a)
Tie1 16
Tie1 36
  • 93 (a)
(Monodelphis domestica)
Mammalia TIE1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TIE1 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Tie1 35
  • 87.88 (n)
  • 92.69 (a)
(Gallus gallus)
Aves TIE1 35
  • 68.52 (n)
  • 66.58 (a)
TIE1 36
  • 65 (a)
(Anolis carolinensis)
Reptilia TIE1 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tie1 35
  • 60.88 (n)
  • 62.28 (a)
(Danio rerio)
Actinopterygii tie1 35
  • 59.45 (n)
  • 59.3 (a)
tie1 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tie 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea ver-3 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for TIE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIE1 Gene

Gene Tree for TIE1 (if available)
Gene Tree for TIE1 (if available)

Paralogs for TIE1 Gene

Paralogs for TIE1 Gene

genes like me logo Genes that share paralogs with TIE1: view

Variants for TIE1 Gene

Sequence variations from dbSNP and Humsavar for TIE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8966 -- 43,322,939(-) AACTA(A/G)AAAAA utr-variant-3-prime
rs839997 -- 43,322,501(-) TTACC(A/G)GCCCA intron-variant
rs866332 -- 43,323,187(+) CCGGG(C/T)GTGGT downstream-variant-500B
rs1098182 -- 43,320,097(+) ACTTC(C/G)TGCTT intron-variant
rs1098183 -- 43,320,664(+) tggct(A/G)acaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIE1 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV Loss 17160897
esv2747574 CNV Deletion 23290073

Relevant External Links for TIE1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIE1 Gene

Disorders for TIE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TIE1 Gene including...

Search for TIE1 Gene in MalaCards »

(22) Novoseek inferred disease relationships for TIE1 Gene

Disease -log(P) Hits PubMed IDs
inflammatory breast cancer 49.5 2
neovascularization 44.1 1
cns tumors 31.5 1
tumors 31.4 23
rheumatoid arthritis 28.1 5

Relevant External Links for TIE1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TIE1: view

No data available for UniProtKB/Swiss-Prot for TIE1 Gene

Publications for TIE1 Gene

  1. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PMID: 18593464) Jin P. … Paleolog E.M. (Arthritis Res. Ther. 2008) 3 4 23
  2. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. (PMID: 1312667) Partanen J. … Alitalo K. (Mol. Cell. Biol. 1992) 2 3 4
  3. The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta. (PMID: 18675456) Seval Y. … Demir R. (Placenta 2008) 3 23
  4. Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function. (PMID: 19236867) Chan B. … Sukhatme V.P. (FEBS Lett. 2009) 3 23
  5. Expression of tie1 and tie2 proteins during reendothelialization in balloon-injured rat carotid artery. (PMID: 10474040) Fujikawa K. … Varticovski L. (J. Vasc. Res. 1999) 3 23

Products for TIE1 Gene

  • Addgene plasmids for TIE1

Sources for TIE1 Gene

Back to Top