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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TIE1 Gene

protein-coding   GIFtS: 62
GCID: GC01P043766

tyrosine kinase with immunoglobulin-like and EGF-like domains...

(Previous name: tyrosine kinase with immunoglobulin and epidermal growth...)
(Previous symbol: TIE)
 Explore 44 diseases affiliated with
TIE1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TIE1    

Aliases
for TIE1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 11 2     EC 2.7.10.13 8
TIE1 2 3 5     Tyrosine-Protein Kinase Receptor Tie-12
JTK141 2 5     EC 2.7.108
Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology
Domains 11 2
     

External Ids:    HGNC: 118091   Entrez Gene: 70752   Ensembl: ENSG000000660567   OMIM: 6002225   UniProtKB: P355903   

Export aliases for TIE1 gene to outside databases

Previous GC identifers: GC01P043437 GC01P043539 GC01P041886


Summaries
for TIE1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TIE1:
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in
angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor
tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by
multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: TIE1_HUMAN, P35590
Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of
angiogenesis




Genomic Views
for TIE1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TIE1 gene promoter:
         Spz1   Elk-1   Egr-1   CUTL1   LCR-F1   POU2F1   POU2F1a   POU2F1b   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TIE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34-p33   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34-p33

TIE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIE1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P043766:  view genomic region     (about GC identifiers)

Start:
 43,766,664 bp from pter      End:
 43,788,779 bp from pter
Size:
 22,116 bases      Orientation:
 plus strand

Proteins
for TIE1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TIE1_HUMAN, P35590 (See protein sequence)
Recommended Name: Tyrosine-protein kinase receptor Tie-1 precursor  
Size: 1138 amino acids; 125090 Da
Subunit: Heterodimer with TEK/TIE2
Subcellular location: Cell membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for TIE1: NX_P35590

Post-translational modifications:

  • Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35590

    • 4/13 DME Specific Peptides for TIE1 (P35590) (see all 13)
     NCDDEVY  FTYAGID  RDLAARN  WMAIESL 

    TIE1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001240286.1  NP_005415.1  

    ENSEMBL proteins: 
     ENSP00000361554   ENSP00000361553   ENSP00000401903   ENSP00000440063   ENSP00000411728  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TIE1 (Tie-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TIE1
    OriGene Protein Over-expression Lysate: TIE1
    OriGene Custom Protein Services for TIE1 
    GenScript Custom Purified and Recombinant Proteins Services for TIE1
    Novus Biologicals TIE1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TIE1
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS1312667
    GO:0016021integral to membrane ----


    TIE1 for ontologies           About GeneDecksing



    TIE1 Antibody Products: 
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    Novus Biologicals TIE1 Antibodies
    Search for Antibodies for TIE1 at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for TIE1

    Assay Products for TIE1: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for TIE1 (Tie-1)         (see all)
    GenScript Custom Assay Services for TIE1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for TIE1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TIE1 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR003599 Ig_sub
     IPR000742 EG-like_dom
     IPR003961 Fibronectin_type3
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P35590

    ProtoNet protein and cluster: P35590

    3 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB006210 Type I EGF
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: TIE1_HUMAN, P35590
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily
    Similarity: Contains 3 EGF-like domains
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Function
    for TIE1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TIE1_HUMAN, P35590
    Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of
    angiogenesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TIE1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIE1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIE1:
    hsa-miR-922 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: TIE1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIE1 (see all 7)
    OriGene shRNA RFP: TIE1
    OriGene siRNA: TIE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIE1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TIE1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIE1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIE1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TIE1 (NM_005424)
    Sino Biological Human cDNA Clone for TIE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIE1 

    Cell Line
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    Search LifeMap BioReagents cell lines for TIE1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIE1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    TIE1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for TIE1:
     Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Increased cell death in HCC-19  Increased mitotic index 

    Animal Models:
         Mouse knock-outs for TIE1: Tie1tm1Sato Tie1tm1.1Scba
         13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tie1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     nervous system  renal/urinary system  respiratory system 

    TIE1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TIE1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_PDGF signaling via STATs and NF-kB
    		Development Angiopoietin - Tie2 signaling0.38
    		Development_Angiopoietin - Tie2 signaling0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TIE1
        Development Angiopoietin - Tie2 signaling


    1 GeneGo (Thomson Reuters) Pathway for TIE1
        Development Angiopoietin - Tie2 signaling



    TIE1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TIE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for TIE1 (P355901, 2, 3 ENSP000003615544) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279863, ENSP000002743354I2D: score=2 STRING: ENSP00000274335
    TEKQ027633, ENSP000003839774I2D: score=2 STRING: ENSP00000383977
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    PTPRCP085753, ENSP000003563464I2D: score=1 STRING: ENSP00000356346
    PTPRJQ129133, ENSP000004000104I2D: score=1 STRING: ENSP00000400010
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0007165signal transduction TAS1312667
    GO:0007498mesoderm development TAS7596437
    GO:0016525negative regulation of angiogenesis IEA--


    TIE1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TIE1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TIE1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TIE1

    2 HMDB Compounds for TIE1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    4 Novoseek chemical compound relationships for TIE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 72.9 54 10913057 (2), 10949653 (2), 12853700 (2), 14530387 (2) (see all 41)
    vegf 71.7 58 8939195 (3), 19376222 (3), 10694277 (3), 11866538 (3) (see all 30)
    nitric oxide 0 3 17132814 (1), 19662988 (1), 17379831 (1)
    glucose 0 2 15613462 (1), 17494864 (1)

    Search CenterWatch for drugs/clinical trials and news about TIE1 

    Transcripts
    for TIE1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TIE1 gene (2 alternative transcripts): 
    NM_001253357.1  NM_005424.4  

    Unigene Cluster for TIE1:

    Tyrosine kinase with immunoglobulin-like and EGF-like domains 1
    Hs.78824  [show with all ESTs]
    Unigene Representative Sequence: NM_005424
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372476(uc010oka.2 uc010okb.2 uc010okc.2 uc010okd.2 uc010okf.1 uc010oke.2 uc001ciu.3 uc009vwq.3 uc010okg.2)
    ENST00000372475(uc021omo.1) ENST00000485125 ENST00000480269 ENST00000488437
    ENST00000471187 ENST00000461061 ENST00000473014 ENST00000492599 ENST00000492874
    ENST00000441333 ENST00000538015 ENST00000433781

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TIE1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIE1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TIE1:
    hsa-miR-922 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: TIE1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIE1 (see all 7)
    OriGene shRNA RFP: TIE1
    OriGene siRNA: TIE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIE1
    Clone
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    GenScript: all cDNA clones in your preferred vector: TIE1 (NM_005424)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIE1

    Additional cDNA sequence: 

    AF217976.1 AK225560.1 AK296735.1 AK300399.1 AK300623.1 AK307639.1 BC038239.1 EU826586.1 
    EU826587.1 EU826588.1 EU826589.1 EU826590.1 GU166386.1 X60957.1 

    12 DOTS entries:

    DT.415745  DT.121328166  DT.92427592  DT.121328153  DT.91710036  DT.92427596  DT.121328170  DT.92427595 
    DT.97798813  DT.100705053  DT.40262086  DT.92043278 

    24/161 AceView cDNA sequences (see all 161):

    BC038239 BI523784 AI239977 BI758078 BQ878590 BX348301 BQ719791 X60957 
    AW452236 BF847824 BI824583 AL833389 AJ708186 BF847819 BM996123 BM970991 
    CB993023 CA432662 BF849487 BI010593 AF217976 BG012156 CR601214 BF850172 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TIE1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                    -     -                                                                                               -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -     -                                                                                                                                 
    SP5:                    -                                                                                                                                       

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:  -                           
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for TIE1

    Expression
    for TIE1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TIE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGTTCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TIE1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalEndocardial Tube CellsEndocardium
    HeartEndocardiumEndocardial CellsEndocardium
    HeartOutflow TractEndocardial Tube CellsEndocardium
    Lateral Plate MesodermProepicardiumAngioblastsEndothelium
    Lateral Plate MesodermEmbryonic Blood IslandsAngioblastsEndothelium
    PlacentaChorionic VillusExtraembryonic Hemangioblast CellsBlood, Endothelium
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    BoneZeugopod PeriosteumBone
    HeartHeart TubeHeart
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)Bone
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

    See TIE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TIE1

    SOURCE GeneReport for Unigene cluster: Hs.78824

    UniProtKB/Swiss-Prot: TIE1_HUMAN, P35590
    Tissue specificity: Specifically expressed in developing vascular endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including TIE1: 
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIE1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIE1

    Orthologs
    for TIE1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TIE1 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TIE11 tyrosine kinase with immunoglobulin-like and EGF-like more 68.74(n)
    67.15(a)    		   424562  XM_422400.3  XP_422400.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TIE16
    		 --
    		 64(a)
    		 1 ↔ 1
    		 4(107180931-107212820)
    zebrafish
    (Danio rerio)    		 Actinopterygii tie11 endothelium-specific receptor tyrosine kinase 1 60.36(n)
    60.21(a)    		   30746  XM_001334637.5  XP_001334673.4 


    ENSEMBL Gene Tree for TIE1 (if available)
    TreeFam Gene Tree for TIE1 (if available) 

    Paralogs
    for TIE1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TIE1 gene
    AXL2  MET2  RYK2  TEK2  TYRO32  MERTK2  MST1R2  
    18/81 SIMAP similar genes for TIE1 using alignment to 3 protein entries:     TIE1_HUMAN (see all proteins) (see all similar genes):
    TIE    TEK    ABL1    FLT1    BTK kinase deficient isoform 6    CCDC6-RETa
    CCDC6-RETc    RET/PTC2    TXK    EPHA2    urf-ret    tec
    MATK    SRC    RET    FGFR2    FGR    MERTK

    TIE1 for paralogs           About GeneDecksing



    Genomic Variants
    for TIE1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/487 NCBI SNPs in TIE1 are shown (see all 487)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs740695491,2
    		C,--41885146(+) CATCCA/GTCCCA 2 -- us2k12Minor allele frequency- G:0.08WA 120
    rs66783631,2
    		C,F,H,--41885202(+) GCTGCC/ACATCC 2 -- us2k110Minor allele frequency- A:0.03NS EA NA WA 1212
    rs728785581,2
    		C,--41885442(+) GCACCT/ACCCTG 2 -- us2k12Minor allele frequency- A:0.04WA 120
    rs740695501,2
    		C,--41885927(+) TGTGCC/TGGGGG 2 -- us2k12Minor allele frequency- T:0.10WA 120
    rs747973881,2
    		F,--41886164(+) CTTGTG/CGGGGC 2 -- us2k11Minor allele frequency- C:0.10WA 118
    rs611942631,2
    		--41886907(+) GCTCAC/TGCCTG 2 -- int10--------
    rs66716241,2
    		C,F,H,--41887176(+) aaaaaA/Tagatg 2 -- int1 trp35Minor allele frequency- T:0.04NS EA WA 510
    rs780642201,2
    		C,--41887399(+) AGGGGG/TTGTTC 2 -- int13Minor allele frequency- T:0.06CSA WA 121
    rs1124362461,2
    		C,--41887487(+) GTGCTA/GAGTGC 2 -- int13Minor allele frequency- G:0.10CSA WA 121
    rs120969891,2
    		H,--41887794(+) GAGTTC/TAGCTT 2 -- int14Minor allele frequency- T:0.00NS EA 420

    HapMap Linkage Disequilibrium report for TIE1 (43766664 - 43788779 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TIE1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIE1
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    Disorders / Diseases
    for TIE1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TIE1 for disorders           About GeneDecksing

    OMIM gene information: 600222    OMIM disorders: --

    20/44 diseases for TIE1 (see all 44):    About MalaCards
    cavernous malformation    non-small cell lung carcinoma    cerebral cavernous malformations    arteriovenous malformation
    gastrointestinal stromal tumor    venous malformations    inflammatory breast cancer    angiosarcoma
    giant cell tumor    myeloid leukemia    rheumatoid arthritis    chronic lymphocytic leukemia
    chronic myeloid leukemia    acute myeloid leukemia    lymphocytic leukemia    hemangiopericytoma
    hepatopulmonary syndrome    angiofibroma    kaposi's sarcoma    hemangioblastoma

    10/22 Novoseek disease relationships for TIE1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory breast cancer 49.5 2 15585631 (2)
    neovascularization 44.1 1 12853700 (1)
    cns tumors 31.5 1 7856749 (1)
    tumors 31.4 32 12853700 (5), 11501841 (3), 10027415 (2), 7856749 (1) (see all 16)
    rheumatoid arthritis 28.1 7 10913057 (2), 19236867 (1), 11261813 (1), 12010571 (1)
    angiosarcoma 23.8 4 10854238 (3)
    colon tumor 23.3 1 12853700 (1)
    adenocarcinoma gastric 22.5 1 14987226 (1)
    atherosclerosis 12.4 3 18448073 (1), 19236867 (1)
    carcinoma ductal 11.2 1 12853700 (1)

    Human Genome Epidemiology (HuGE) Navigator: TIE1 (5 documents)

    Export disorders for TIE1 gene to outside databases

    Publications
    for TIE1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TIE1 gene, integrated from 9 sources (see all 143):
    (articles sorted by number of sources associating them with TIE1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. (PubMed id 1312667)1, 2, 3 Partanen J.... Alitalo K. (1992)
    2. Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. (PubMed id 20227369)1, 2 Seegar T.C....Barton W.A. (2010)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. (PubMed id 17728252)1, 9 Marron M.B....Brindle N.P. (2007)
    6. Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2. (PubMed id 10995770)1, 9 Marron M.B....Brindle N.P. (2000)
    7. Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia. (PubMed id 11920509)1, 9 Verstovsek S....Albitar M. (2002)
    8. Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells. (PubMed id 8547681)1, 9 Hashiyama M....Suda T. (1996)
    9. A noncoding antisense RNA in tie-1 locus regulates ti e-1 function in vivo. (PubMed id 19880500)1, 9 Li K....Ramchandran R. (2010)
    10. Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function. (PubMed id 19236867)1, 9 Chan B. and Sukhatme V.P. (2009)

    External Searches for TIE1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TIE1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7075 HGNC: 11809 AceView: TIE Ensembl:ENSG00000066056 euGenes: HUgn7075
    ECgene: TIE1 H-InvDB: TIE1

    Other Databases showing TIE1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TIE1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TIE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIE1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TIE1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TIE1 gene:
    Search GeneIP for patents involving TIE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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