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Aliases for TIE1 Gene

Aliases for TIE1 Gene

  • Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1 2 3 5
  • Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1 2 3
  • EC 4 61
  • TIE 3 4
  • Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1 2
  • Tyrosine-Protein Kinase Receptor Tie-1 3
  • EC 2.7.10 61
  • JTK14 3

External Ids for TIE1 Gene

Previous HGNC Symbols for TIE1 Gene

  • TIE

Previous GeneCards Identifiers for TIE1 Gene

  • GC01P043437
  • GC01P043539
  • GC01P043766
  • GC01P041886

Summaries for TIE1 Gene

Entrez Gene Summary for TIE1 Gene

  • This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIE1 Gene

TIE1 (Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEK.

UniProtKB/Swiss-Prot for TIE1 Gene

  • Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIE1 Gene

Genomics for TIE1 Gene

Regulatory Elements for TIE1 Gene

Enhancers for TIE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F043539 1.7 FANTOM5 Ensembl ENCODE 4.5 +246.6 246589 15.4 ARNT MLX ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF143 DEK LOC101929592 PTPRF MED8 SZT2 ST3GAL3 KDM4A-AS1 IPO13 LOC101929609 HYI DPH2
GH01F043266 0.6 ENCODE 11.1 -33.2 -33206 1.6 ZNF263 HDAC1 RNF2 ZNF175 ZMYM3 FOSL1 CREB3 ZNF589 ZNF512 CFAP57 TIE1 SZT2 TMEM125 LOC105378685
GH01F043293 1.4 FANTOM5 Ensembl ENCODE 2 -5.9 -5895 4.0 HDGF TBP JUN KLF17 ASH2L RAD21 RELA YY1 SOX5 STAT1 MED8 EBNA1BP2 MIR6733 MPL LOC105378687 CDC20 MIR6734 ELOVL1 ENSG00000229431 SZT2
GH01F043301 0.7 ENCODE 0.8 +1.9 1916 1.7 PKNOX1 KLF17 ZNF121 ZFHX2 EED SCRT2 EGR2 ZNF16 TBX21 ETS2 MED8 LOC101929609 DMAP1 HYI TIE1 PIR52122
GH01F043321 0.8 ENCODE 0.3 +20.6 20619 0.8 SOX13 ATF1 TFAP4 SAP130 JUN MAX ARID4B ZNF644 RARA TEAD3 MED8 CDC20 LOC105378687 MIR6734 ELOVL1 PTPRF SZT2 ENSG00000229431 PIR52122 TIE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIE1 on UCSC Golden Path with GeneCards custom track

Promoters for TIE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000535537 1005 1801 PKNOX1 MTA2 KLF17 ZNF16 TBX21 ZNF121 RAD51 POLR2A SCRT2 IKZF1

Genomic Location for TIE1 Gene

43,300,895 bp from pter
43,323,110 bp from pter
22,216 bases
Plus strand

Genomic View for TIE1 Gene

Genes around TIE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIE1 Gene

Proteins for TIE1 Gene

  • Protein details for TIE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein kinase receptor Tie-1
    Protein Accession:
    Secondary Accessions:
    • B5A949
    • B5A950

    Protein attributes for TIE1 Gene

    1138 amino acids
    Molecular mass:
    125090 Da
    Quaternary structure:
    • Heterodimer with TEK/TIE2.

    Alternative splice isoforms for TIE1 Gene


neXtProt entry for TIE1 Gene

Selected DME Specific Peptides for TIE1 Gene


Post-translational modifications for TIE1 Gene

  • Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • Glycosylation at Asn 83, Asn 161, Asn 503, Asn 596, and Asn 709
  • Modification sites at PhosphoSitePlus

Other Protein References for TIE1 Gene

Antibody Products

  • Abcam antibodies for TIE1

Domains & Families for TIE1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EGF-like domains.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
  • Contains 3 EGF-like domains.
  • Contains 3 fibronectin type-III domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
genes like me logo Genes that share domains with TIE1: view

Function for TIE1 Gene

Molecular function for TIE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Enzyme Numbers (IUBMB) for TIE1 Gene

Gene Ontology (GO) - Molecular Function for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA,TAS --
GO:0005515 protein binding IPI 21982860
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TIE1: view
genes like me logo Genes that share phenotypes with TIE1: view

Animal Models for TIE1 Gene

MGI Knock Outs for TIE1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TIE1 Gene

Localization for TIE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIE1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIE1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 1312667
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIE1: view

Pathways & Interactions for TIE1 Gene

genes like me logo Genes that share pathways with TIE1: view

SIGNOR curated interactions for TIE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001568 blood vessel development IEA --
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with TIE1: view

Drugs & Compounds for TIE1 Gene

(4) Drugs for TIE1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for TIE1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TIE1: view

Transcripts for TIE1 Gene

Unigene Clusters for TIE1 Gene

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP4: - -
SP5: -
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -

Relevant External Links for TIE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIE1 Gene

This gene is overexpressed in Plasma (53.8) and Bone (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIE1 Gene

Protein tissue co-expression partners for TIE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIE1 Gene:


SOURCE GeneReport for Unigene cluster for TIE1 Gene:


mRNA Expression by UniProt/SwissProt for TIE1 Gene:

Tissue specificity: Specifically expressed in developing vascular endothelial cells.
genes like me logo Genes that share expression patterns with TIE1: view

Primer Products

No data available for mRNA differential expression in normal tissues for TIE1 Gene

Orthologs for TIE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIE1 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia TIE1 34 35
  • 89.9 (n)
(Canis familiaris)
Mammalia TIE1 34 35
  • 89.69 (n)
(Rattus norvegicus)
Mammalia Tie1 34
  • 87.88 (n)
(Mus musculus)
Mammalia Tie1 34 16 35
  • 87.76 (n)
(Monodelphis domestica)
Mammalia TIE1 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TIE1 35
  • 70 (a)
(Gallus gallus)
Aves TIE1 34 35
  • 68.52 (n)
(Anolis carolinensis)
Reptilia TIE1 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tie1 34
  • 60.88 (n)
(Danio rerio)
Actinopterygii tie1 34 35
  • 59.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tie 35
  • 17 (a)
(Caenorhabditis elegans)
Secernentea ver-3 35
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for TIE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIE1 Gene

Gene Tree for TIE1 (if available)
Gene Tree for TIE1 (if available)

Paralogs for TIE1 Gene

Paralogs for TIE1 Gene

genes like me logo Genes that share paralogs with TIE1: view

Variants for TIE1 Gene

Sequence variations from dbSNP and Humsavar for TIE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1098182 -- 43,320,097(+) ACTTC(C/G)TGCTT intron-variant
rs1098183 -- 43,320,664(+) tggct(A/G)acaca intron-variant
rs1098184 -- 43,320,680(+) acccc(A/G)tctct intron-variant
rs111252191 -- 43,321,661(+) GAGCG(A/G)CCCCC nc-transcript-variant, reference, synonymous-codon
rs111494871 -- 43,308,345(+) AGTGG(A/G)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIE1 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV loss 17160897
nsv546128 CNV loss 21841781
esv2747574 CNV deletion 23290073

Variation tolerance for TIE1 Gene

Residual Variation Intolerance Score: 3.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIE1 Gene

Disorders for TIE1 Gene

Relevant External Links for TIE1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIE1 Gene

Publications for TIE1 Gene

  1. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PMID: 18593464) Jin P. … Paleolog E.M. (Arthritis Res. Ther. 2008) 3 4 22 64
  2. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. (PMID: 1312667) Partanen J. … Alitalo K. (Mol. Cell. Biol. 1992) 2 3 4 64
  3. A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. (PMID: 19880500) Li K. … Ramchandran R. (Blood 2010) 3 22 64
  4. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts K.E. … Fallon M.B. (Gastroenterology 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for TIE1 Gene

Sources for TIE1 Gene

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