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Aliases for TIE1 Gene

Aliases for TIE1 Gene

  • Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1 2 3 5
  • Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1 2 3
  • EC 4 56
  • TIE 3 4
  • Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1 2
  • Tyrosine-Protein Kinase Receptor Tie-1 3
  • EC 2.7.10 56
  • JTK14 3

External Ids for TIE1 Gene

Previous HGNC Symbols for TIE1 Gene

  • TIE

Previous GeneCards Identifiers for TIE1 Gene

  • GC01P043437
  • GC01P043539
  • GC01P043766
  • GC01P041886

Summaries for TIE1 Gene

Entrez Gene Summary for TIE1 Gene

  • This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIE1 Gene

TIE1 (Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEK.

UniProtKB/Swiss-Prot for TIE1 Gene

  • Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Additional gene information for TIE1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIE1 Gene

Genomics for TIE1 Gene

GeneHancer (GH) Regulatory Elements for TIE1 Gene

Promoters and enhancers for TIE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I043300 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.4 1412 2.7 KLF17 ZNF16 NFIL3 ZFHX2 ZNF585B POLR2A CEBPA HNF4A WT1 EGR2 GC01P043301 TIE1 MED8 FOXJ3 LOC101929609 ARTN SZT2 DMAP1 HYI PIR52122
GH01I043266 Enhancer 0.7 ENCODE dbSUPER 11.1 -33.2 -33206 1.6 ZNF3 RXRA ZMYM3 HNF4A CFAP57 TIE1 SZT2 EBNA1BP2 TMEM125 LOC105378685
GH01I043539 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +246.6 246589 15.4 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 GC01M043545 LOC101929592 PTPRF MED8 ST3GAL3 KDM4A-AS1 IPO13 LOC101929609 HYI DPH2
GH01I043323 Enhancer 0.5 dbSUPER 12.4 +23.5 23481 1.8 FOSL1 SMARCA4 BATF SETDB1 TIE1 LOC105378687 CDC20 ELOVL1 ENSG00000229431 MED8 SZT2 PIR52122
GH01I043293 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2 -5.8 -5822 3.8 HDGF FOXA2 KLF17 RAD21 YY1 ATF7 ETV6 IKZF2 RUNX3 RXRA MED8 EBNA1BP2 MPL LOC105378687 CDC20 ELOVL1 ENSG00000229431 SZT2 FAM183A ATP6V0B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIE1 gene promoter:

Genomic Locations for TIE1 Gene

Genomic Locations for TIE1 Gene
22,216 bases
Plus strand

Genomic View for TIE1 Gene

Genes around TIE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIE1 Gene

Proteins for TIE1 Gene

  • Protein details for TIE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tyrosine-protein kinase receptor Tie-1
    Protein Accession:
    Secondary Accessions:
    • B5A949
    • B5A950

    Protein attributes for TIE1 Gene

    1138 amino acids
    Molecular mass:
    125090 Da
    Quaternary structure:
    • Heterodimer with TEK/TIE2.

    Three dimensional structures from OCA and Proteopedia for TIE1 Gene

    Alternative splice isoforms for TIE1 Gene


neXtProt entry for TIE1 Gene

Selected DME Specific Peptides for TIE1 Gene


Post-translational modifications for TIE1 Gene

  • Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • Glycosylation at posLast=8383, posLast=161161, posLast=503503, isoforms=596, and posLast=709709

Other Protein References for TIE1 Gene

Domains & Families for TIE1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
genes like me logo Genes that share domains with TIE1: view

Function for TIE1 Gene

Molecular function for TIE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Enzyme Numbers (IUBMB) for TIE1 Gene

Phenotypes From GWAS Catalog for TIE1 Gene

Gene Ontology (GO) - Molecular Function for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS,IEA --
GO:0005515 protein binding IPI 21982860
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TIE1: view
genes like me logo Genes that share phenotypes with TIE1: view

Animal Models for TIE1 Gene

MGI Knock Outs for TIE1:

Clone Products

  • Addgene plasmids for TIE1

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TIE1 Gene

Localization for TIE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIE1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIE1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 1312667
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TIE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIE1 Gene

Pathways & Interactions for TIE1 Gene

genes like me logo Genes that share pathways with TIE1: view

Pathways by source for TIE1 Gene

SIGNOR curated interactions for TIE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001568 blood vessel development IEA --
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with TIE1: view

Drugs & Compounds for TIE1 Gene

(4) Drugs for TIE1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(2) Additional Compounds for TIE1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TIE1: view

Transcripts for TIE1 Gene

Unigene Clusters for TIE1 Gene

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TIE1

Alternative Splicing Database (ASD) splice patterns (SP) for TIE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP4: - -
SP5: -
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -

Relevant External Links for TIE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIE1 Gene

This gene is overexpressed in Plasma (53.8) and Bone (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIE1 Gene

Protein tissue co-expression partners for TIE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIE1 Gene:


SOURCE GeneReport for Unigene cluster for TIE1 Gene:


mRNA Expression by UniProt/SwissProt for TIE1 Gene:

Tissue specificity: Specifically expressed in developing vascular endothelial cells.

Evidence on tissue expression from TISSUES for TIE1 Gene

  • Lung(4.6)
  • Nervous system(3.7)
  • Heart(3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TIE1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIE1 Gene

Orthologs for TIE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIE1 33 34
  • 99.56 (n)
(Bos Taurus)
Mammalia TIE1 33 34
  • 89.9 (n)
(Canis familiaris)
Mammalia TIE1 33 34
  • 89.69 (n)
(Rattus norvegicus)
Mammalia Tie1 33
  • 87.88 (n)
(Mus musculus)
Mammalia Tie1 33 16 34
  • 87.76 (n)
(Monodelphis domestica)
Mammalia TIE1 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TIE1 34
  • 70 (a)
(Gallus gallus)
Aves TIE1 33 34
  • 68.52 (n)
(Anolis carolinensis)
Reptilia TIE1 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tie1 33
  • 60.88 (n)
(Danio rerio)
Actinopterygii tie1 33 34
  • 59.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tie 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea ver-3 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for TIE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIE1 Gene

Gene Tree for TIE1 (if available)
Gene Tree for TIE1 (if available)

Paralogs for TIE1 Gene

Paralogs for TIE1 Gene

genes like me logo Genes that share paralogs with TIE1: view

Variants for TIE1 Gene

Sequence variations from dbSNP and Humsavar for TIE1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008078 -- 43,310,288(+) G/T intron_variant
rs1000042253 -- 43,303,521(+) C/T intron_variant
rs1000089908 -- 43,323,427(+) C/G downstream_transcript_variant
rs1000254972 -- 43,304,583(+) G/A intron_variant
rs1000459608 -- 43,318,598(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIE1 Gene

Variant ID Type Subtype PubMed ID
esv2747574 CNV deletion 23290073
nsv546128 CNV loss 21841781
nsv829693 CNV loss 17160897

Variation tolerance for TIE1 Gene

Residual Variation Intolerance Score: 3.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIE1 Gene

Disorders for TIE1 Gene

Additional Disease Information for TIE1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TIE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIE1 Gene

Publications for TIE1 Gene

  1. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PMID: 18593464) Jin P … Paleolog EM (Arthritis research & therapy 2008) 3 4 22 58
  2. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. (PMID: 1312667) Partanen J … Alitalo K (Molecular and cellular biology 1992) 2 3 4 58
  3. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts KE … Pulmonary Vascular Complications of Liver Disease Study Group (Gastroenterology 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. (PMID: 20227369) Seegar TC … Barton WA (Molecular cell 2010) 3 4 58

Products for TIE1 Gene

Sources for TIE1 Gene

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