Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIE1 Gene

Aliases for TIE1 Gene

  • Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1 2 3
  • Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1 2 3
  • EC 2.7.10.1 4 63
  • TIE 3 4
  • EC 2.7.10 63
  • JTK14 3

External Ids for TIE1 Gene

Previous HGNC Symbols for TIE1 Gene

  • TIE

Previous GeneCards Identifiers for TIE1 Gene

  • GC01P043437
  • GC01P043539
  • GC01P043766
  • GC01P041886

Summaries for TIE1 Gene

Entrez Gene Summary for TIE1 Gene

  • This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIE1 Gene

TIE1 (Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STYK1.

UniProtKB/Swiss-Prot for TIE1 Gene

  • Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIE1 Gene

Genomics for TIE1 Gene

Regulatory Elements for TIE1 Gene

Genomic Location for TIE1 Gene

Chromosome:
1
Start:
43,300,895 bp from pter
End:
43,323,110 bp from pter
Size:
22,216 bases
Orientation:
Plus strand

Genomic View for TIE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIE1 Gene

Proteins for TIE1 Gene

  • Protein details for TIE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35590-TIE1_HUMAN
    Recommended name:
    Tyrosine-protein kinase receptor Tie-1
    Protein Accession:
    P35590
    Secondary Accessions:
    • B5A949
    • B5A950

    Protein attributes for TIE1 Gene

    Size:
    1138 amino acids
    Molecular mass:
    125090 Da
    Quaternary structure:
    • Heterodimer with TEK/TIE2

    Alternative splice isoforms for TIE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIE1 Gene

Proteomics data for TIE1 Gene at MOPED

Post-translational modifications for TIE1 Gene

  • Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • Glycosylation at Asn 83, Asn 161, Asn 503, Asn 596, and Asn 709
  • Modification sites at PhosphoSitePlus

Other Protein References for TIE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for TIE1 Gene

Graphical View of Domain Structure for InterPro Entry

P35590

UniProtKB/Swiss-Prot:

TIE1_HUMAN :
  • Contains 3 EGF-like domains.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Domain:
  • Contains 3 EGF-like domains.
  • Contains 3 fibronectin type-III domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
genes like me logo Genes that share domains with TIE1: view

Function for TIE1 Gene

Molecular function for TIE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Enzyme Numbers (IUBMB) for TIE1 Gene

Gene Ontology (GO) - Molecular Function for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 21982860
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TIE1: view
genes like me logo Genes that share phenotypes with TIE1: view

Animal Models for TIE1 Gene

MGI Knock Outs for TIE1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIE1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for TIE1 Gene

Localization for TIE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIE1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIE1 Gene COMPARTMENTS Subcellular localization image for TIE1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 1312667
genes like me logo Genes that share ontologies with TIE1: view

Pathways & Interactions for TIE1 Gene

genes like me logo Genes that share pathways with TIE1: view

Pathways by source for TIE1 Gene

1 GeneGo (Thomson Reuters) pathway for TIE1 Gene
1 R&D Systems pathway for TIE1 Gene

PCR Array Products

SIGNOR curated interactions for TIE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001568 blood vessel development --
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006468 protein phosphorylation --
genes like me logo Genes that share ontologies with TIE1: view

Drugs & Compounds for TIE1 Gene

(3) Drugs for TIE1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Nitric Oxide Approved Pharma 540
tyrosine Nutra 547

(3) Additional Compounds for TIE1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
glucose
VEGF
genes like me logo Genes that share compounds with TIE1: view

Transcripts for TIE1 Gene

Unigene Clusters for TIE1 Gene

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIE1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: -
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TIE1 Gene

GeneLoc Exon Structure for
TIE1
ECgene alternative splicing isoforms for
TIE1

Expression for TIE1 Gene

mRNA expression in normal human tissues for TIE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIE1 Gene

This gene is overexpressed in Plasma (53.8) and Bone (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIE1 Gene



SOURCE GeneReport for Unigene cluster for TIE1 Gene Hs.78824

mRNA Expression by UniProt/SwissProt for TIE1 Gene

P35590-TIE1_HUMAN
Tissue specificity: Specifically expressed in developing vascular endothelial cells
genes like me logo Genes that share expression patterns with TIE1: view

Protein tissue co-expression partners for TIE1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TIE1 Gene

Orthologs for TIE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIE1 35
  • 89.9 (n)
  • 93.22 (a)
TIE1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIE1 35
  • 89.69 (n)
  • 93.5 (a)
TIE1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tie1 35
  • 87.76 (n)
  • 93.12 (a)
Tie1 16
Tie1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIE1 35
  • 99.56 (n)
  • 99.65 (a)
TIE1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tie1 35
  • 87.88 (n)
  • 92.69 (a)
oppossum
(Monodelphis domestica)
Mammalia TIE1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIE1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIE1 35
  • 68.52 (n)
  • 66.58 (a)
TIE1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIE1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tie1 35
  • 60.88 (n)
  • 62.28 (a)
zebrafish
(Danio rerio)
Actinopterygii tie1 35
  • 59.45 (n)
  • 59.3 (a)
tie1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tie 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ver-3 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TIE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIE1 Gene

ENSEMBL:
Gene Tree for TIE1 (if available)
TreeFam:
Gene Tree for TIE1 (if available)

Paralogs for TIE1 Gene

Paralogs for TIE1 Gene

genes like me logo Genes that share paralogs with TIE1: view

Variants for TIE1 Gene

Sequence variations from dbSNP and Humsavar for TIE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8966 -- 43,322,939(-) AACTA(A/G)AAAAA utr-variant-3-prime, nc-transcript-variant
rs839997 -- 43,322,501(-) TTACC(A/G)GCCCA intron-variant
rs866332 -- 43,323,187(+) CCGGG(C/T)GTGGT downstream-variant-500B
rs1098182 -- 43,320,097(+) ACTTC(C/G)TGCTT intron-variant
rs1098183 -- 43,320,664(+) tggct(A/G)acaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIE1 Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV Loss 17160897
esv2747574 CNV Deletion 23290073

Variation tolerance for TIE1 Gene

Residual Variation Intolerance Score: 3.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIE1 Gene

HapMap Linkage Disequilibrium report
TIE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIE1 Gene

Disorders for TIE1 Gene

Relevant External Links for TIE1

Genetic Association Database (GAD)
TIE1
Human Genome Epidemiology (HuGE) Navigator
TIE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIE1
genes like me logo Genes that share disorders with TIE1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIE1 Gene

Publications for TIE1 Gene

  1. Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. (PMID: 19922791) Hansen T.M. … Brindle N.P. (Cell. Signal. 2010) 23 67
  2. The expression of angiogenic growth factors and their receptors in ovarian follicles throughout the estrous cycle in the ewe. (PMID: 20042232) Chowdhury M.W. … Khalid M. (Theriogenology 2010) 23 67
  3. A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. (PMID: 19880500) Li K. … Ramchandran R. (Blood 2010) 23 67
  4. Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. (PMID: 19285068) Gu A. … Shively J.E. (Exp. Cell Res. 2009) 23 67
  5. Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis. (PMID: 18848573) Milner C.S. … Brindle N.P. (Microvasc. Res. 2009) 23 67

Products for TIE1 Gene

Sources for TIE1 Gene

Back to Top

Content