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Aliases for TICRR Gene

Aliases for TICRR Gene

  • TOPBP1 Interacting Checkpoint And Replication Regulator 2 3 5
  • TopBP1-Interacting Checkpoint And Replication Regulator 3 4
  • C15orf42 3 4
  • TopBP1-Interacting, Replication-Stimulating Protein 4
  • TOPBP1-Interacting Replication-Stimulating Protein 2
  • TopBP1-Interacting Replication-Stimulating Protein 3
  • Chromosome 15 Open Reading Frame 42 2
  • SLD3 Homolog (S. Cerevisiae) 2
  • Treslin 3
  • SLD3 3

External Ids for TICRR Gene

Previous HGNC Symbols for TICRR Gene

  • C15orf42

Previous GeneCards Identifiers for TICRR Gene

  • GC15P090119

Summaries for TICRR Gene

Entrez Gene Summary for TICRR Gene

  • Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TICRR Gene

TICRR (TOPBP1 Interacting Checkpoint And Replication Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for TICRR Gene

  • Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICRR Gene

Genomics for TICRR Gene

Regulatory Elements for TICRR Gene

Enhancers for TICRR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G090071 1.5 Ensembl ENCODE dbSUPER 11.9 +498.6 498553 6.3 PKNOX1 ZNF133 ARID4B SIN3A ZNF2 ZNF121 GATA2 ZNF143 FOS JUNB NIFKP5 TICRR ENSG00000270322 ZNF710 ENSG00000276376 PIR55871
GH15G089086 1.7 FANTOM5 ENCODE dbSUPER 9.8 -484.3 -484252 9.0 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B LOC102724566 POLG RNU7-195P ENSG00000261407 ABHD2 LOC100631255 TICRR HAPLN3 ISG20 GC15M089095
GH15G090182 1.4 ENCODE dbSUPER 11.8 +609.3 609287 3.9 CREB3L1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 ZNF610 GLIS1 POLG SEMA4B NIFKP5 TICRR ENSG00000270322 ENSG00000259314 CIB1 PIR44533 GC15P090181
GH15G090387 1.4 ENCODE dbSUPER 9.8 +813.4 813356 2.8 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IQGAP1 LOC100631255 ENSG00000259314 ZNF774 TICRR ENSG00000259177
GH15G090306 1.1 Ensembl ENCODE 11.8 +731.3 731325 1.0 ZFP64 RELB IKZF2 CREM EGR2 ZNF202 ZNF680 CBFB ZBTB11 CEBPB IQGAP1 ENSG00000259314 POLG NIFKP5 TICRR ENSG00000270322 GABARAPL3 ZNF774 ENSG00000261478 NGRN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TICRR on UCSC Golden Path with GeneCards custom track

Promoters for TICRR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080935 363 2400 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 FOS

Genomic Location for TICRR Gene

Chromosome:
15
Start:
89,575,438 bp from pter
End:
89,631,056 bp from pter
Size:
55,619 bases
Orientation:
Plus strand

Genomic View for TICRR Gene

Genes around TICRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TICRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TICRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICRR Gene

Proteins for TICRR Gene

  • Protein details for TICRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2Z1-TICRR_HUMAN
    Recommended name:
    Treslin
    Protein Accession:
    Q7Z2Z1
    Secondary Accessions:
    • B2RE07
    • B3KVV9
    • D3IUT4
    • Q8N4X8
    • Q8NCH6
    • Q9BU55

    Protein attributes for TICRR Gene

    Size:
    1910 amino acids
    Molecular mass:
    210857 Da
    Quaternary structure:
    • Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner.
    SequenceCaution:
    • Sequence=BAC11165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38104.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG53921.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TICRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TICRR Gene

Post-translational modifications for TICRR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TICRR Gene

No data available for DME Specific Peptides for TICRR Gene

Domains & Families for TICRR Gene

Protein Domains for TICRR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TICRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z2Z1

UniProtKB/Swiss-Prot:

TICRR_HUMAN :
  • Belongs to the treslin family.
Family:
  • Belongs to the treslin family.
genes like me logo Genes that share domains with TICRR: view

No data available for Gene Families for TICRR Gene

Function for TICRR Gene

Molecular function for TICRR Gene

UniProtKB/Swiss-Prot Function:
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

Gene Ontology (GO) - Molecular Function for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20080954
GO:0005515 protein binding IPI 20080954
genes like me logo Genes that share ontologies with TICRR: view
genes like me logo Genes that share phenotypes with TICRR: view

Animal Model Products

CRISPR Products

miRNA for TICRR Gene

miRTarBase miRNAs that target TICRR

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TICRR Gene

Localization for TICRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICRR Gene

Nucleus. Note=Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TICRR gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20080954
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TICRR: view

Pathways & Interactions for TICRR Gene

SuperPathways for TICRR Gene

No Data Available

Interacting Proteins for TICRR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268138%0d%0a9606.ENSP00000260810%0d%0a9606.ENSP00000274026%0d%0a
Selected Interacting proteins: ENSP00000268138 Q7Z2Z1-TICRR_HUMAN for TICRR Gene via STRING IID

Gene Ontology (GO) - Biological Process for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint ISS --
GO:0001731 formation of translation preinitiation complex ISS --
GO:0006260 DNA replication ISS,IEA --
GO:0006281 DNA repair ISS --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with TICRR: view

No data available for Pathways by source and SIGNOR curated interactions for TICRR Gene

Drugs & Compounds for TICRR Gene

No Compound Related Data Available

Transcripts for TICRR Gene

Unigene Clusters for TICRR Gene

TOPBP1-interacting checkpoint and replication regulator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TICRR Gene

No ASD Table

Relevant External Links for TICRR Gene

GeneLoc Exon Structure for
TICRR
ECgene alternative splicing isoforms for
TICRR

Expression for TICRR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TICRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TICRR Gene

This gene is overexpressed in Esophagus - Mucosa (x7.0).

Protein differential expression in normal tissues from HIPED for TICRR Gene

This gene is overexpressed in Plasma (36.2), Tlymphocyte (23.6), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TICRR Gene



Protein tissue co-expression partners for TICRR Gene

NURSA nuclear receptor signaling pathways regulating expression of TICRR Gene:

TICRR

SOURCE GeneReport for Unigene cluster for TICRR Gene:

Hs.441708

Evidence on tissue expression from TISSUES for TICRR Gene

  • Lung(4)
  • Muscle(4)
genes like me logo Genes that share expression patterns with TICRR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TICRR Gene

Orthologs for TICRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for TICRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICRR 34 35
  • 98.13 (n)
dog
(Canis familiaris)
Mammalia TICRR 34 35
  • 82 (n)
cow
(Bos Taurus)
Mammalia TICRR 34 35
  • 80.81 (n)
mouse
(Mus musculus)
Mammalia Ticrr 34 16 35
  • 77.74 (n)
rat
(Rattus norvegicus)
Mammalia Ticrr 34
  • 77.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TICRR 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TICRR 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF42 34
  • 60.03 (n)
TICRR 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TICRR 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ticrr 34
  • 53.76 (n)
Species where no ortholog for TICRR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TICRR Gene

ENSEMBL:
Gene Tree for TICRR (if available)
TreeFam:
Gene Tree for TICRR (if available)

Paralogs for TICRR Gene

No data available for Paralogs for TICRR Gene

Variants for TICRR Gene

Sequence variations from dbSNP and Humsavar for TICRR Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs113145397 Likely benign 89,627,988(+) AAAGA(-/T)TTTTT utr-variant-3-prime
rs145726393 Uncertain significance 89,628,453(+) TCCCC(A/G/T)GGCTG downstream-variant-500B, reference, missense
rs147387691 Uncertain significance 89,628,382(+) AGGCT(C/G/T)GGAGT downstream-variant-500B, utr-variant-3-prime
rs150248985 Uncertain significance 89,628,507(+) TCCAG(A/G)GCAGG downstream-variant-500B, reference, missense
rs370152166 Uncertain significance 89,628,383(+) GGCTC(A/G)GAGTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TICRR Gene

Variant ID Type Subtype PubMed ID
esv2750005 CNV deletion 23290073
esv34025 CNV loss 18971310
esv3637198 CNV loss 21293372
esv3892721 CNV gain 25118596
nsv1038140 CNV gain 25217958
nsv1160317 CNV duplication 26073780
nsv1659 CNV deletion 18451855
nsv521260 CNV loss 19592680

Variation tolerance for TICRR Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.43; 99.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TICRR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TICRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TICRR Gene

Disorders for TICRR Gene

Relevant External Links for TICRR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TICRR

No disorders were found for TICRR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TICRR Gene

Publications for TICRR Gene

  1. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. (PMID: 20080954) Sansam C.L. … Lees J.A. (Genes Dev. 2010) 2 3 4 64
  2. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. (PMID: 20116089) Kumagai A. … Dunphy W.G. (Cell 2010) 2 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase. (PMID: 26405041) Bruck I. … Kaplan D.L. (J. Biol. Chem. 2015) 3 64

Products for TICRR Gene

Sources for TICRR Gene

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