Aliases for TICRR Gene
External Ids for TICRR Gene
Previous Symbols for TICRR Gene
Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
GeneCards Summary for TICRR Gene
TICRR (TOPBP1-Interacting Checkpoint And Replication Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot for TICRR Gene
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.