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Aliases for TICRR Gene

Aliases for TICRR Gene

  • TOPBP1 Interacting Checkpoint And Replication Regulator 2 3
  • TopBP1-Interacting Checkpoint And Replication Regulator 4 5
  • TopBP1-Interacting, Replication-Stimulating Protein 3 4
  • C15orf42 3 4
  • TOPBP1-Interacting Checkpoint And Replication Regulator 3
  • TOPBP1-Interacting Replication-Stimulating Protein 2
  • TopBP1-Interacting Replication-Stimulating Protein 3
  • Chromosome 15 Open Reading Frame 42 2
  • SLD3 Homolog (S. Cerevisiae) 2
  • Treslin 3
  • SLD3 3

External Ids for TICRR Gene

Previous HGNC Symbols for TICRR Gene

  • C15orf42

Previous GeneCards Identifiers for TICRR Gene

  • GC15P090119

Summaries for TICRR Gene

Entrez Gene Summary for TICRR Gene

  • Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TICRR Gene

TICRR (TOPBP1 Interacting Checkpoint And Replication Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for TICRR Gene

  • Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICRR Gene

Genomics for TICRR Gene

Regulatory Elements for TICRR Gene

Enhancers for TICRR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TICRR on UCSC Golden Path with GeneCards custom track

Promoters for TICRR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TICRR on UCSC Golden Path with GeneCards custom track

Genomic Location for TICRR Gene

Chromosome:
15
Start:
89,575,438 bp from pter
End:
89,631,056 bp from pter
Size:
55,619 bases
Orientation:
Plus strand

Genomic View for TICRR Gene

Genes around TICRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TICRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TICRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICRR Gene

Proteins for TICRR Gene

  • Protein details for TICRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2Z1-TICRR_HUMAN
    Recommended name:
    Treslin
    Protein Accession:
    Q7Z2Z1
    Secondary Accessions:
    • B2RE07
    • B3KVV9
    • D3IUT4
    • Q8N4X8
    • Q8NCH6
    • Q9BU55

    Protein attributes for TICRR Gene

    Size:
    1910 amino acids
    Molecular mass:
    210857 Da
    Quaternary structure:
    • Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner.
    SequenceCaution:
    • Sequence=BAC11165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38104.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG53921.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TICRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TICRR Gene

Proteomics data for TICRR Gene at MOPED

Post-translational modifications for TICRR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TICRR Gene

No data available for DME Specific Peptides for TICRR Gene

Domains & Families for TICRR Gene

Protein Domains for TICRR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TICRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z2Z1

UniProtKB/Swiss-Prot:

TICRR_HUMAN :
  • Belongs to the treslin family.
Family:
  • Belongs to the treslin family.
genes like me logo Genes that share domains with TICRR: view

No data available for Gene Families for TICRR Gene

Function for TICRR Gene

Molecular function for TICRR Gene

UniProtKB/Swiss-Prot Function:
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
genes like me logo Genes that share phenotypes with TICRR: view

Animal Model Products

miRNA for TICRR Gene

miRTarBase miRNAs that target TICRR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TICRR Gene

Localization for TICRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICRR Gene

Nucleus. Note=Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TICRR Gene COMPARTMENTS Subcellular localization image for TICRR gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for TICRR Gene

Pathways & Interactions for TICRR Gene

SuperPathways for TICRR Gene

No Data Available

Interacting Proteins for TICRR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268138%0d%0a9606.ENSP00000260810%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000268138 for TICRR Gene via STRING

Gene Ontology (GO) - Biological Process for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint ISS --
GO:0001731 formation of translation preinitiation complex ISS --
GO:0010212 response to ionizing radiation IEA,ISS --
genes like me logo Genes that share ontologies with TICRR: view

No data available for Pathways by source and SIGNOR curated interactions for TICRR Gene

Drugs & Compounds for TICRR Gene

No Compound Related Data Available

Transcripts for TICRR Gene

Unigene Clusters for TICRR Gene

TOPBP1-interacting checkpoint and replication regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TICRR Gene

No ASD Table

Relevant External Links for TICRR Gene

GeneLoc Exon Structure for
TICRR
ECgene alternative splicing isoforms for
TICRR

Expression for TICRR Gene

mRNA expression in normal human tissues for TICRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TICRR Gene

This gene is overexpressed in Esophagus - Mucosa (x7.0).

Protein differential expression in normal tissues from HIPED for TICRR Gene

This gene is overexpressed in Plasma (36.2), Tlymphocyte (23.6), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TICRR Gene



SOURCE GeneReport for Unigene cluster for TICRR Gene Hs.441708

genes like me logo Genes that share expression patterns with TICRR: view

Protein tissue co-expression partners for TICRR Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TICRR Gene

Orthologs for TICRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for TICRR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TICRR 35
  • 80.81 (n)
  • 73.34 (a)
TICRR 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TICRR 35
  • 82 (n)
  • 74.73 (a)
TICRR 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ticrr 35
  • 77.74 (n)
  • 70.19 (a)
Ticrr 16
Ticrr 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TICRR 35
  • 98.13 (n)
  • 97.54 (a)
TICRR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ticrr 35
  • 77.55 (n)
  • 70.09 (a)
oppossum
(Monodelphis domestica)
Mammalia TICRR 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TICRR 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves TICRR 36
  • 41 (a)
OneToOne
C10H15ORF42 35
  • 60.03 (n)
  • 51.39 (a)
lizard
(Anolis carolinensis)
Reptilia TICRR 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ticrr 35
  • 53.76 (n)
  • 44.93 (a)
Species with no ortholog for TICRR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TICRR Gene

ENSEMBL:
Gene Tree for TICRR (if available)
TreeFam:
Gene Tree for TICRR (if available)

Paralogs for TICRR Gene

No data available for Paralogs for TICRR Gene

Variants for TICRR Gene

Sequence variations from dbSNP and Humsavar for TICRR Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_034631 -, -
rs10775247 - 89,582,890(+) TAAAC(C/T)GTTTG reference, missense
rs11629584 - 89,585,735(+) AAGGC(C/T)GGCCC reference, missense
rs12905387 - 89,601,384(+) AGTAG(C/T)GGAGG reference, missense
VAR_050889 -

Variation tolerance for TICRR Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.43; 99.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TICRR Gene

HapMap Linkage Disequilibrium report
TICRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TICRR Gene

Disorders for TICRR Gene

Relevant External Links for TICRR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TICRR

No disorders were found for TICRR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TICRR Gene

Publications for TICRR Gene

  1. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. (PMID: 20080954) Sansam C.L. … Lees J.A. (Genes Dev. 2010) 2 3 4 67
  2. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. (PMID: 20116089) Kumagai A. … Dunphy W.G. (Cell 2010) 2 3
  3. Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation. (PMID: 25737283) Sansam C.G. … Sansam C.L. (Genes Dev. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase. (PMID: 26405041) Bruck I. … Kaplan D.L. (J. Biol. Chem. 2015) 3

Products for TICRR Gene

Sources for TICRR Gene

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