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Aliases for TICRR Gene

Aliases for TICRR Gene

  • TOPBP1-Interacting Checkpoint And Replication Regulator 2 3
  • C15orf42 3 4 6
  • TopBP1-Interacting, Replication-Stimulating Protein 3 4
  • Treslin 3 6
  • TopBP1-Interacting Checkpoint And Replication Regulator 4
  • TOPBP1-Interacting Replication-Stimulating Protein 2
  • TopBP1-Interacting Replication-Stimulating Protein 3
  • Chromosome 15 Open Reading Frame 42 2
  • SLD3 Homolog (S. Cerevisiae) 2
  • SLD3 Homolog 3
  • SLD3 3

External Ids for TICRR Gene

Previous HGNC Symbols for TICRR Gene

  • C15orf42

Previous GeneCards Identifiers for TICRR Gene

  • GC15P090119

Summaries for TICRR Gene

Entrez Gene Summary for TICRR Gene

  • Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TICRR Gene

TICRR (TOPBP1-Interacting Checkpoint And Replication Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for TICRR Gene

  • Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICRR Gene

Genomics for TICRR Gene

Genomic Location for TICRR Gene

Start:
89,575,482 bp from pter
End:
89,631,056 bp from pter
Size:
55,575 bases
Orientation:
Plus strand

Genomic View for TICRR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TICRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICRR Gene

No data available for Regulatory Elements for TICRR Gene

Proteins for TICRR Gene

  • Protein details for TICRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2Z1-TICRR_HUMAN
    Recommended name:
    Treslin
    Protein Accession:
    Q7Z2Z1
    Secondary Accessions:
    • B2RE07
    • B3KVV9
    • D3IUT4
    • Q8N4X8
    • Q8NCH6
    • Q9BU55

    Protein attributes for TICRR Gene

    Size:
    1910 amino acids
    Molecular mass:
    210857 Da
    Quaternary structure:
    • Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner.
    SequenceCaution:
    • Sequence=BAC11165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38104.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG53921.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TICRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TICRR Gene

Proteomics data for TICRR Gene at MOPED

Post-translational modifications for TICRR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TICRR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TICRR Gene

Domains for TICRR Gene

Protein Domains for TICRR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TICRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z2Z1

UniProtKB/Swiss-Prot:

TICRR_HUMAN :
  • Q7Z2Z1
Family:
  • Belongs to the treslin family.
genes like me logo Genes that share domains with TICRR: view

No data available for Gene Families for TICRR Gene

Function for TICRR Gene

Molecular function for TICRR Gene

UniProtKB/Swiss-Prot Function: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

Gene Ontology (GO) - Molecular Function for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20080954
GO:0005515 protein binding IPI 20080954
genes like me logo Genes that share ontologies with TICRR: view
genes like me logo Genes that share phenotypes with TICRR: view

miRNA for TICRR Gene

miRTarBase miRNAs that target TICRR

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TICRR Gene

Localization for TICRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICRR Gene

Nucleus. Note=Associates with chromatin.

Gene Ontology (GO) - Cellular Components for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20080954
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TICRR: view

No data available for Subcellular locations from COMPARTMENTS for TICRR Gene

Pathways for TICRR Gene

SuperPathways for TICRR Gene

No Data Available

Interacting Proteins for TICRR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268138%0d%0a9606.ENSP00000260810%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000268138 for TICRR Gene via STRING

Gene Ontology (GO) - Biological Process for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint ISS --
GO:0001731 formation of translation preinitiation complex ISS --
GO:0006260 DNA replication ISS --
GO:0006281 DNA repair ISS --
GO:0010212 response to ionizing radiation ISS --
genes like me logo Genes that share ontologies with TICRR: view

No data available for Pathways by source for TICRR Gene

Transcripts for TICRR Gene

Unigene Clusters for TICRR Gene

TOPBP1-interacting checkpoint and replication regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TICRR Gene

No ASD Table

Relevant External Links for TICRR Gene

GeneLoc Exon Structure for
TICRR
ECgene alternative splicing isoforms for
TICRR

Expression for TICRR Gene

mRNA expression in normal human tissues for TICRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TICRR Gene

This gene is overexpressed in Esophagus - Mucosa (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TICRR Gene

SOURCE GeneReport for Unigene cluster for TICRR Gene Hs.441708

genes like me logo Genes that share expressions with TICRR: view

No data available for mRNA Expression by UniProt/SwissProt for TICRR Gene

Orthologs for TICRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for TICRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICRR 35
  • 98.13 (n)
  • 97.54 (a)
TICRR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TICRR 35
  • 80.81 (n)
  • 73.34 (a)
TICRR 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TICRR 35
  • 82 (n)
  • 74.73 (a)
TICRR 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ticrr 35
  • 77.74 (n)
  • 70.19 (a)
Ticrr 16
Ticrr 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TICRR 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TICRR 36
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ticrr 35
  • 77.55 (n)
  • 70.09 (a)
chicken
(Gallus gallus)
Aves C10H15ORF42 35
  • 60.03 (n)
  • 51.39 (a)
TICRR 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TICRR 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ticrr 35
  • 53.76 (n)
  • 44.93 (a)
Species with no ortholog for TICRR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TICRR Gene

ENSEMBL:
Gene Tree for TICRR (if available)
TreeFam:
Gene Tree for TICRR (if available)

Paralogs for TICRR Gene

No data available for Paralogs for TICRR Gene

Variants for TICRR Gene

Sequence variations from dbSNP and Humsavar for TICRR Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs765264 -- 89,590,768(-) AATGC(A/C/G)TACTT intron-variant
rs893723 -- 89,585,679(-) TGAGA(A/G)TATTA intron-variant
rs893724 -- 89,585,568(-) CATTA(A/T)TAGAG intron-variant
rs893725 -- 89,584,992(-) ACATT(G/T)CTACA intron-variant
rs920562 -- 89,612,197(-) ataca(C/T)acttt intron-variant

Relevant External Links for TICRR Gene

HapMap Linkage Disequilibrium report
TICRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TICRR Gene

Disorders for TICRR Gene

No disorders were found for TICRR Gene.

No data available for UniProtKB/Swiss-Prot for TICRR Gene

Publications for TICRR Gene

  1. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. (PMID: 20080954) Sansam C.L. … Lees J.A. (Genes Dev. 2010) 2 3 4
  2. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. (PMID: 20116089) Kumagai A. … Dunphy W.G. (Cell 2010) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Homology explains the functional similarities of Treslin/Ticrr and Sld3. (PMID: 20620901) Sanchez-Pulido L. … Ponting C.P. (Curr. Biol. 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TICRR Gene

Sources for TICRR Gene

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