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Aliases for TICAM2 Gene

Aliases for TICAM2 Gene

  • Toll-Like Receptor Adaptor Molecule 2 2 3
  • TRAM 3 4 6
  • TIRP 3 4 6
  • Putative NF-Kappa-B-Activating Protein 502 3 4
  • Toll-Like Receptor Adaptor Protein 3 3 4
  • MyD88-4 3 4
  • TICAM-2 3 4
  • TIRAP3 3 4
  • Toll/Interleukin-1 Receptor (TIR) Domain-Containing Adapter Protein 3
  • Toll/Interleukin-1 Receptor Domain-Containing Protein 4
  • TIR Domain-Containing Adapter Molecule 2 3
  • NF-Kappa-B-Activating Protein 502 3
  • TRIF-Related Adaptor Molecule 3
  • TRIF-Related Adapter Molecule 4
  • Cytoplasmic Adaptor 3

External Ids for TICAM2 Gene

Previous GeneCards Identifiers for TICAM2 Gene

  • GC00U917008
  • GC05M114942
  • GC05M110096

Summaries for TICAM2 Gene

Entrez Gene Summary for TICAM2 Gene

  • TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]

GeneCards Summary for TICAM2 Gene

TICAM2 (Toll-Like Receptor Adaptor Molecule 2) is a Protein Coding gene. Diseases associated with TICAM2 include vaccinia. Among its related pathways are NF-kappa B signaling pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED3.

UniProtKB/Swiss-Prot for TICAM2 Gene

  • Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response

  • Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes

Gene Wiki entry for TICAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICAM2 Gene

Genomics for TICAM2 Gene

Regulatory Elements for TICAM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TICAM2 Gene

Start:
115,578,642 bp from pter
End:
115,602,479 bp from pter
Size:
23,838 bases
Orientation:
Minus strand

Genomic View for TICAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICAM2 Gene

Proteins for TICAM2 Gene

  • Protein details for TICAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XR7-TCAM2_HUMAN
    Recommended name:
    TIR domain-containing adapter molecule 2
    Protein Accession:
    Q86XR7
    Secondary Accessions:
    • B3Y698
    • Q6JUT2

    Protein attributes for TICAM2 Gene

    Size:
    235 amino acids
    Molecular mass:
    26916 Da
    Quaternary structure:
    • Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner. Interacts with IL18R1 and IL18RAP.

    Three dimensional structures from OCA and Proteopedia for TICAM2 Gene

    Alternative splice isoforms for TICAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TICAM2 Gene

Proteomics data for TICAM2 Gene at MOPED

Post-translational modifications for TICAM2 Gene

  • Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TICAM2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TICAM2 Gene

Domains for TICAM2 Gene

Protein Domains for TICAM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TICAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XR7

UniProtKB/Swiss-Prot:

TCAM2_HUMAN :
  • Q86XR7
Domain:
  • The TIR domain mediates the interaction with TRAF6 and MYD88.
  • Contains 1 TIR domain.
genes like me logo Genes that share domains with TICAM2: view

No data available for Gene Families for TICAM2 Gene

Function for TICAM2 Gene

Molecular function for TICAM2 Gene

UniProtKB/Swiss-Prot Function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response
UniProtKB/Swiss-Prot Function: Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes

Gene Ontology (GO) - Molecular Function for TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 25416956
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with TICAM2: view

Phenotypes for TICAM2 Gene

MGI mutant phenotypes for TICAM2:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with TICAM2: view

Animal Models for TICAM2 Gene

MGI Knock Outs for TICAM2:

Animal Model Products

CRISPR Products

miRNA for TICAM2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TICAM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TICAM2 Gene

Localization for TICAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICAM2 Gene

Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.
Isoform 2: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TICAM2 Gene COMPARTMENTS Subcellular localization image for TICAM2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
endosome 4
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IDA 19412184
GO:0005770 late endosome IDA 19412184
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with TICAM2: view

Pathways for TICAM2 Gene

genes like me logo Genes that share pathways with TICAM2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TICAM2 Gene

Selected Interacting proteins: Q86XR7-TCAM2_HUMAN for TICAM2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006915 apoptotic process TAS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with TICAM2: view

Transcripts for TICAM2 Gene

mRNA/cDNA for TICAM2 Gene

(366) Selected AceView cDNA sequences:
(15) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TICAM2 Gene

Toll-like receptor adaptor molecule 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TICAM2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TICAM2 Gene

No ASD Table

Relevant External Links for TICAM2 Gene

GeneLoc Exon Structure for
TICAM2
ECgene alternative splicing isoforms for
TICAM2

Expression for TICAM2 Gene

mRNA expression in normal human tissues for TICAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TICAM2 Gene

SOURCE GeneReport for Unigene cluster for TICAM2 Gene Hs.718838

mRNA Expression by UniProt/SwissProt for TICAM2 Gene

Q86XR7-TCAM2_HUMAN
Tissue specificity: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
genes like me logo Genes that share expressions with TICAM2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TICAM2 Gene

Orthologs for TICAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICAM2 35
  • 99.43 (n)
  • 99.57 (a)
TICAM2 36
  • 93 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TICAM2 35
  • 83.76 (n)
  • 81.03 (a)
TICAM2 36
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TICAM2 35
  • 75.04 (n)
  • 76.17 (a)
TMED7 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ticam2 35
  • 78.59 (n)
  • 75.43 (a)
Ticam2 16
Ticam2 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ticam2 35
  • 78.59 (n)
  • 78.02 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmed7 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta p24-1 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B10.5 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 36
  • 48 (a)
OneToMany
Species with no ortholog for TICAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TICAM2 Gene

ENSEMBL:
Gene Tree for TICAM2 (if available)
TreeFam:
Gene Tree for TICAM2 (if available)

Paralogs for TICAM2 Gene

Paralogs for TICAM2 Gene

genes like me logo Genes that share paralogs with TICAM2: view

Variants for TICAM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv830455 CNV Gain 17160897

Relevant External Links for TICAM2 Gene

HapMap Linkage Disequilibrium report
TICAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TICAM2 Gene

Disorders for TICAM2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TICAM2 Gene including...

Search for TICAM2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TICAM2 Gene

Relevant External Links for TICAM2

Genetic Association Database (GAD)
TICAM2
Human Genome Epidemiology (HuGE) Navigator
TICAM2
genes like me logo Genes that share disorders with TICAM2: view

No data available for UniProtKB/Swiss-Prot for TICAM2 Gene

Publications for TICAM2 Gene

  1. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PMID: 12721283) Bin L.-H. … Shu H.-B. (J. Biol. Chem. 2003) 3 4 23
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  3. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. (PMID: 14517278) Fitzgerald K.A. … Golenbock D.T. (J. Exp. Med. 2003) 3 4
  4. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon- beta. (PMID: 14519765) Oshiumi H. … Seya T. (J. Biol. Chem. 2003) 3 4
  5. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. (PMID: 16603631) Rowe D.C. … Golenbock D.T. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4

Products for TICAM2 Gene

Sources for TICAM2 Gene

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