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Aliases for TICAM2 Gene

Aliases for TICAM2 Gene

  • Toll Like Receptor Adaptor Molecule 2 2 3 5
  • Putative NF-Kappa-B-Activating Protein 502 3 4
  • Toll-Like Receptor Adaptor Protein 3 3 4
  • MyD88-4 3 4
  • TICAM-2 3 4
  • TIRAP3 3 4
  • TIRP 3 4
  • TRAM 3 4
  • Toll/Interleukin-1 Receptor (TIR) Domain-Containing Adapter Protein 3
  • Toll/Interleukin-1 Receptor Domain-Containing Protein 4
  • TIR Domain-Containing Adapter Molecule 2 3
  • Toll-Like Receptor Adaptor Molecule 2 2
  • NF-Kappa-B-Activating Protein 502 3
  • TRIF-Related Adaptor Molecule 3
  • TRIF-Related Adapter Molecule 4
  • Cytoplasmic Adaptor 3

External Ids for TICAM2 Gene

Previous GeneCards Identifiers for TICAM2 Gene

  • GC00U917008
  • GC05M114942
  • GC05M110096

Summaries for TICAM2 Gene

Entrez Gene Summary for TICAM2 Gene

  • TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]

GeneCards Summary for TICAM2 Gene

TICAM2 (Toll Like Receptor Adaptor Molecule 2) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways and MyD88 cascade initiated on plasma membrane. GO annotations related to this gene include signal transducer activity and phospholipid binding. An important paralog of this gene is TMED7-TICAM2.

UniProtKB/Swiss-Prot for TICAM2 Gene

  • Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.

  • Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Gene Wiki entry for TICAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICAM2 Gene

Genomics for TICAM2 Gene

Regulatory Elements for TICAM2 Gene

Enhancers for TICAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TICAM2 on UCSC Golden Path with GeneCards custom track

Promoters for TICAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TICAM2 Gene

Chromosome:
5
Start:
115,578,496 bp from pter
End:
115,602,479 bp from pter
Size:
23,984 bases
Orientation:
Minus strand

Genomic View for TICAM2 Gene

Genes around TICAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TICAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICAM2 Gene

Proteins for TICAM2 Gene

  • Protein details for TICAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XR7-TCAM2_HUMAN
    Recommended name:
    TIR domain-containing adapter molecule 2
    Protein Accession:
    Q86XR7
    Secondary Accessions:
    • B3Y698
    • Q6JUT2

    Protein attributes for TICAM2 Gene

    Size:
    235 amino acids
    Molecular mass:
    26916 Da
    Quaternary structure:
    • Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner. Interacts with IL18R1 and IL18RAP.

    Three dimensional structures from OCA and Proteopedia for TICAM2 Gene

    Alternative splice isoforms for TICAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TICAM2 Gene

Post-translational modifications for TICAM2 Gene

  • Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TICAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TICAM2 Gene

Domains & Families for TICAM2 Gene

Gene Families for TICAM2 Gene

Protein Domains for TICAM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TICAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XR7

UniProtKB/Swiss-Prot:

TCAM2_HUMAN :
  • The TIR domain mediates the interaction with TRAF6 and MYD88.
Domain:
  • The TIR domain mediates the interaction with TRAF6 and MYD88.
  • Contains 1 TIR domain.
genes like me logo Genes that share domains with TICAM2: view

Function for TICAM2 Gene

Molecular function for TICAM2 Gene

UniProtKB/Swiss-Prot Function:
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
UniProtKB/Swiss-Prot Function:
Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Gene Ontology (GO) - Molecular Function for TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IEA,IPI 17258210
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with TICAM2: view
genes like me logo Genes that share phenotypes with TICAM2: view

Animal Models for TICAM2 Gene

MGI Knock Outs for TICAM2:

Animal Model Products

CRISPR Products

miRNA for TICAM2 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TICAM2 Gene

Localization for TICAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICAM2 Gene

Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.
Isoform 2: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TICAM2 Gene COMPARTMENTS Subcellular localization image for TICAM2 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with TICAM2: view

Pathways & Interactions for TICAM2 Gene

genes like me logo Genes that share pathways with TICAM2: view

SIGNOR curated interactions for TICAM2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006954 inflammatory response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS --
GO:0032729 positive regulation of interferon-gamma production IEA --
GO:0032755 positive regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with TICAM2: view

Drugs & Compounds for TICAM2 Gene

No Compound Related Data Available

Transcripts for TICAM2 Gene

mRNA/cDNA for TICAM2 Gene

Unigene Clusters for TICAM2 Gene

Toll-like receptor adaptor molecule 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TICAM2 Gene

No ASD Table

Relevant External Links for TICAM2 Gene

GeneLoc Exon Structure for
TICAM2
ECgene alternative splicing isoforms for
TICAM2

Expression for TICAM2 Gene

mRNA expression in normal human tissues for TICAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TICAM2 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TICAM2 Gene



Protein tissue co-expression partners for TICAM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TICAM2 Gene:

TICAM2

SOURCE GeneReport for Unigene cluster for TICAM2 Gene:

Hs.718838

mRNA Expression by UniProt/SwissProt for TICAM2 Gene:

Q86XR7-TCAM2_HUMAN
Tissue specificity: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
genes like me logo Genes that share expression patterns with TICAM2: view

Primer Products

No data available for mRNA differential expression in normal tissues for TICAM2 Gene

Orthologs for TICAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TICAM2 34
  • 83.76 (n)
  • 81.03 (a)
TICAM2 35
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TICAM2 34
  • 75.04 (n)
  • 76.17 (a)
TMED7 35
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ticam2 34
  • 78.59 (n)
  • 75.43 (a)
Ticam2 16
Ticam2 35
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TICAM2 34
  • 99.43 (n)
  • 99.57 (a)
TICAM2 35
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ticam2 34
  • 78.59 (n)
  • 78.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmed7 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta p24-1 35
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B10.5 35
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 35
  • 48 (a)
OneToMany
Species where no ortholog for TICAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TICAM2 Gene

ENSEMBL:
Gene Tree for TICAM2 (if available)
TreeFam:
Gene Tree for TICAM2 (if available)

Paralogs for TICAM2 Gene

Paralogs for TICAM2 Gene

genes like me logo Genes that share paralogs with TICAM2: view

Variants for TICAM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv830455 CNV gain 17160897

Variation tolerance for TICAM2 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TICAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TICAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TICAM2 Gene

Disorders for TICAM2 Gene

Relevant External Links for TICAM2

Genetic Association Database (GAD)
TICAM2
Human Genome Epidemiology (HuGE) Navigator
TICAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TICAM2

No disorders were found for TICAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TICAM2 Gene

Publications for TICAM2 Gene

  1. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PMID: 12721283) Bin L.-H. … Shu H.-B. (J. Biol. Chem. 2003) 3 4 22 65
  2. TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. (PMID: 22685567) Ohnishi H. … Kondo N. (PLoS ONE 2012) 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PMID: 19412184) Palsson-McDermott E.M. … O'Neill L.A. (Nat. Immunol. 2009) 3 4 65
  5. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. (PMID: 19543401) Hawn T.R. … Hooton T.M. (PLoS ONE 2009) 3 46 65

Products for TICAM2 Gene

Sources for TICAM2 Gene

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