Aliases for TICAM2 Gene
External Ids for TICAM2 Gene
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
GeneCards Summary for TICAM2 Gene
TICAM2 (Toll-Like Receptor Adaptor Molecule 2) is a Protein Coding gene. Diseases associated with TICAM2 include vaccinia. Among its related pathways are NF-kappa B signaling pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED3.
UniProtKB/Swiss-Prot for TICAM2 Gene
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response
Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes