Aliases for TICAM2 Gene
External Ids for TICAM2 Gene
Previous GeneCards Identifiers for TICAM2 Gene
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
GeneCards Summary for TICAM2 Gene
TICAM2 (Toll Like Receptor Adaptor Molecule 2) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways and MyD88 cascade initiated on plasma membrane. GO annotations related to this gene include signal transducer activity and phospholipid binding. An important paralog of this gene is TMED7-TICAM2.
UniProtKB/Swiss-Prot for TICAM2 Gene
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.