Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TICAM2 Gene

protein-coding   GIFtS: 54
GCID: GC05M114942

Toll-Like Receptor Adaptor Molecule 2

  See TICAM2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Toll-Like Receptor Adaptor Molecule 21 2     Cytoplasmic Adaptor2
TIRP2 3 5     NF-Kappa-B-Activating Protein 5022
TRAM2 3 5     TIR Domain-Containing Adapter Molecule 22
Putative NF-Kappa-B-Activating Protein 5022 3     Toll/Interleukin-1 Receptor (TIR) Domain-Containing Adapter Protein2
Toll-Like Receptor Adaptor Protein 32 3     TRIF-Related Adaptor Molecule2
MyD88-42 3     Toll/Interleukin-1 Receptor Domain-Containing Protein3
TICAM-22 3     TRIF-Related Adapter Molecule3
TIRAP32 3     

External Ids:    HGNC: 213541   Entrez Gene: 3533762   Ensembl: ENSG000002434147   OMIM: 6083215   UniProtKB: Q86XR73   

Export aliases for TICAM2 gene to outside databases

Previous GC identifers: GC00U917008 GC05M110096


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TICAM2 Gene:
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll
receptor signaling (see TLR4; MIM 603030).(supplied by OMIM, Apr 2004)

GeneCards Summary for TICAM2 Gene:
TICAM2 (toll-like receptor adaptor molecule 2) is a protein-coding gene. Diseases associated with TICAM2 include vaccinia. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7
Function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the
innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to
TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in
IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are
controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18
signaling during adaptive immune response
Function: Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1
thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late
endosomes

Gene Wiki entry for TICAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the TICAM2 gene promoter:
         STAT1   HOXA3   AML1a   GCNF   AREB6   GCNF-1   FOXO4   ZID   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTICAM2 promoter sequence
   Search Chromatin IP Primers for TICAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TICAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22.3

TICAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TICAM2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M114942:  view genomic region     (about GC identifiers)

Start:
114,914,339 bp from pter      End:
114,961,876 bp from pter
Size:
47,538 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7 (See protein sequence)
Recommended Name: TIR domain-containing adapter molecule 2  
Size: 235 amino acids; 26916 Da
Subunit: Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP,
IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts
with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and
TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner.
Interacts with IL18R1 and IL18RAP
1 PDB 3D structure from and Proteopedia for TICAM2:
2M1W (3D)    
Secondary accessions: B3Y698 Q6JUT2
Alternative splicing: 2 isoforms:  Q86XR7-1   Q86XR7-2   

Explore the universe of human proteins at neXtProt for TICAM2: NX_Q86XR7

Explore proteomics data for TICAM2 at MOPED

Post-translational modifications: 

  • Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the
    membrane upon phosphorylation1
  • Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate
    efficient signaling1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TICAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067681.1  
    ENSEMBL proteins: 
     ENSP00000415139   ENSP00000386341  
    Reactome Protein details: Q86XR7

    TICAM2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TICAM2
    OriGene Protein Over-expression Lysate for TICAM2
    OriGene MassSpec for TICAM2
    OriGene Custom Protein Services for TICAM2
    GenScript Custom Purified and Recombinant Proteins Services for TICAM2
    Novus Biologicals TICAM2 Proteins
    Novus Biologicals TICAM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TICAM2
    Cloud-Clone Corp. Proteins for TICAM2

     
    Search eBioscience for Proteins for TICAM2 

     
    antibodies-online proteins for TICAM2 (6 products) 

     
    antibodies-online peptides for TICAM2

    TICAM2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TICAM2
    R&D Systems Antibodies for TICAM2 (TRAM/TICAM2)
    OriGene Antibodies for TICAM2
    OriGene Custom Antibody Services for TICAM2
    Novus Biologicals TICAM2 Antibodies
    Abcam antibodies for TICAM2
    Cloud-Clone Corp. Antibodies for TICAM2
    ThermoFisher Antibodies for TICAM2
    antibodies-online antibodies for TICAM2 (71 products) 

    TICAM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TICAM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TICAM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TICAM2
    Cloud-Clone Corp. CLIAs for TICAM2
    Search eBioscience for ELISAs for TICAM2 
    antibodies-online kits for TICAM2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000157 TIR_dom

    Graphical View of Domain Structure for InterPro Entry Q86XR7

    ProtoNet protein and cluster: Q86XR7

    UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7
    Domain: The TIR domain mediates the interaction with TRAF6 and MYD88
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TICAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAM2_HUMAN, Q86XR7
    Function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the
    innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to
    TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in
    IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are
    controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18
    signaling during adaptive immune response
    Function: Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1
    thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late
    endosomes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TICAM2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ticam2):
     immune system 

    Find genes that share phenotypes with TICAM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TICAM2: Ticam2tm1Aki Ticam2tm1Btlr

       genOway: Develop your customized and physiologically relevant rodent model for TICAM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TICAM2:
    hsa-mir-192-5p (MIRT026317), hsa-mir-30a-5p (MIRT028516), hsa-mir-215-5p (MIRT024278), hsa-mir-155-5p (MIRT020664)

    Block miRNA regulation of human, mouse, rat TICAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TICAM2 (see all 9):
    hsa-miR-4307 hsa-miR-27a hsa-miR-513a-5p hsa-miR-298 hsa-miR-1303 hsa-miR-186 hsa-miR-580 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTICAM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TICAM2
    Predesigned siRNA for gene silencing in human, mouse, rat TICAM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TICAM2

    Clone
    Products:
         
    OriGene clones in human, mouse for TICAM2 (see all 6)
    OriGene ORF clones in mouse, rat for TICAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TICAM2 (NM_021649)
    Sino Biological Human cDNA Clone for TICAM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TICAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TICAM2
    Addgene plasmids for TICAM2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TICAM2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TICAM2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TCAM2_HUMAN, Q86XR7: Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome
    membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation.
    Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform
    2 in late endosomes
    TCAM2_HUMAN, Q86XR7: Isoform 2: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane.
    Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    plasma membrane5
    endosome4
    cytosol2
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA--
    GO:0005770late endosome IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with TICAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TICAM2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    Inflammasome Activation Pathways0.51
    3Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    TRIF-mediated programmed cell death0.00
    Toll Like Receptor 3 (TLR3) Cascade0.69
    4Interleukin-1 signaling
    IL1-mediated signaling events0.45
    5Pertussis
    Pertussis


    Find genes that share SuperPaths with TICAM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TICAM2
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways


    1 GeneGo (Thomson Reuters) Pathway for TICAM2
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    3 BioSystems Pathways for TICAM2
        Toll-like receptor signaling pathway
    IL1-mediated signaling events
    Regulation of toll-like receptor signaling pathway


    Selected Reactome Pathways for TICAM2 (see all 6)
        IKK complex recruitment mediated by RIP1
    TRIF-mediated programmed cell death
    MyD88-independent cascade
    Toll Like Receptor 4 (TLR4) Cascade
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


    4 Kegg Pathways  (Kegg details for TICAM2):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Pertussis
    Hepatitis B

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TICAM2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TICAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for TICAM2 (Q86XR73 ENSP000003863414) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1R1P147783, ENSP000002339464I2D: score=3 STRING: ENSP00000233946
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=2 STRING: ENSP00000072516
    IRAK3Q9Y6163, ENSP000002612334I2D: score=2 STRING: ENSP00000261233
    TICAM1Q8IUC63, ENSP000002482444I2D: score=2 STRING: ENSP00000248244
    TIRAPP587533, ENSP000003764454I2D: score=2 STRING: ENSP00000376445
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006810transport ----
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    Find genes that share ontologies with TICAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TICAM2 (TCAM2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TICAM2 gene: 
    NM_021649.7  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427199(uc003krc.3) ENST00000513729 ENST00000408996(uc003kre.3 uc003krd.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TICAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TICAM2 (see all 9):
    hsa-miR-4307 hsa-miR-27a hsa-miR-513a-5p hsa-miR-298 hsa-miR-1303 hsa-miR-186 hsa-miR-580 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTICAM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TICAM2
    Predesigned siRNA for gene silencing in human, mouse, rat TICAM2
    Clone
    Products:
         
    OriGene clones in human, mouse for TICAM2 (see all 6)
    OriGene ORF clones in mouse, rat for TICAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TICAM2 (NM_021649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TICAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TICAM2
    Addgene plasmids for TICAM2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TICAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for TICAM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TICAM2
      QuantiTect SYBR Green Assays in human, mouse, rat TICAM2
      QuantiFast Probe-based Assays in human, mouse, rat TICAM2

    Selected AceView cDNA sequences (see all 366):

    BE274946 AA427692 AW450623 W32427 AY275836 T39138 AI143515 CB122425 
    AA639647 AB109098 AY304582 AI537661 BQ639833 AA287681 AI687414 BF970324 
    BM129556 BF196537 AY304581 AA476469 BE905763 AY304583 AI423680 AI457158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TICAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATATGTA
    TICAM2 Expression
    About this image


    TICAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    TICAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TICAM2 Protein Expression

    UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7
    Tissue specificity: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood
    leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at
    lower levels than isoform 1)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TICAM2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TICAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for TICAM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TICAM2
    QuantiTect SYBR Green Assays in human, mouse, rat TICAM2
    QuantiFast Probe-based Assays in human, mouse, rat TICAM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TICAM2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ticam21 , 5 toll-like receptor adaptor molecule 21, 5 78.59(n)1
    75.43(a)1
      18 (24.65 cM)5
    2254711  NM_173394.31  NP_775570.11 
     465591555 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    76(a)
    1 → many
    Z(72816763-72823417)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    40(a)
    1 → many
    GL343193.1(8301237-8313846)
    zebrafish
    (Danio rerio)
    Actinopterygii tmed76
    transmembrane emp24 protein transport domain conta...
    69(a)
    1 → many
    8(442391-447707) ENSDARG00000046022
    fruit fly
    (Drosophila melanogaster)
    Insecta p24-16
    p24-related-1
    43(a)
    1 → many
    X(11745364-11746548)
    worm
    (Caenorhabditis elegans)
    Secernentea F57B10.56
    Protein F57B10.5 (F57B10.5) mRNA, complete cds
    49(a)
    1 → many
    I(6562699-6563660) WBGene00019003
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMP246
    Component of the p24 complex; binds to GPI anchor ...
    21(a)
    1 → many
    VII(122694-123305) YGL200C


    ENSEMBL Gene Tree for TICAM2 (if available)
    TreeFam Gene Tree for TICAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TICAM2 gene
    TMED52  TMED12  TMED7-TICAM22  TMED22  TMED32  TMED72  

    Find genes that share paralogs with TICAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TICAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830455CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TICAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for TICAM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608321    OMIM disorders: --

    1 disease for TICAM2:    
    About MalaCards
    vaccinia

    2 diseases from the University of Copenhagen DISEASES database for TICAM2:
    Retinoblastoma     Progressive multifocal leukoencephalopathy

    Find genes that share disorders with TICAM2           About GenesLikeMe

    Genetic Association Database (GAD): TICAM2
    Human Genome Epidemiology (HuGE) Navigator: TICAM2 (3 documents)

    Export disorders for TICAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TICAM2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with TICAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PubMed id 12721283)1, 2, 9 Bin L.-H.... Shu H.-B. (J. Biol. Chem. 2003)
    2. TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. (PubMed id 22685567)1, 2 Ohnishi H....Kondo N. (PLoS ONE 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PubMed id 19412184)1, 2 Palsson-McDermott E.M....O'Neill L.A. (Nat. Immunol. 2009)
    5. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. (PubMed id 19543401)1, 4 Hawn T.R....Hooton T.M. (PLoS ONE 2009)
    6. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2 Nakajima T....Kimura A. (Immunogenetics 2008)
    7. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. (PubMed id 16603631)1, 2 Rowe D.C.... Golenbock D.T. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. (PubMed id 14517278)1, 2 Fitzgerald K.A.... Golenbock D.T. (J. Exp. Med. 2003)
    9. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    10. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon- beta. (PubMed id 14519765)1, 2 Oshiumi H.... Seya T. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 353376 HGNC: 21354 AceView: TICAM2andCGI-109 Ensembl:ENSG00000243414 euGenes: HUgn353376
    ECgene: TICAM2 Kegg: 353376 H-InvDB: TICAM2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TICAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TICAM2 gene:
    Search GeneIP for patents involving TICAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TICAM2
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for TICAM2 (TRAM/TICAM2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TICAM2   OriGene RNAi products in human, mouse, rat for TICAM2  
     OriGene qPCR primer pairs and template standards for TICAM2   OriGene Protein Over-expression Lysate for TICAM2  
     OriGene MassSpec for TICAM2   OriGene clones in human, mouse for TICAM2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TICAM2   OriGene Purified Protein for TICAM2  
     OriGene ORF clones in mouse, rat for TICAM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TICAM2   OriGene Custom Protein Services for TICAM2  

     
     
     Block miRNA regulation of human, mouse, rat TICAM2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TICAM2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TICAM2 Predesigned siRNA for gene silencing in human, mouse, rat TICAM2
     QuantiFast Probe-based Assays in human, mouse, rat TICAM2 QuantiTect SYBR Green Assays in human, mouse, rat TICAM2
     PCR Arrays including human, mouse, rat TICAM2 Search Chromatin IP Primers for TICAM2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TICAM2  GeneGlobe Interaction Network for TICAM2
     Regulatory tfbs in TICAM2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TICAM2 GenScript cDNA clones with any tag delivered in your preferred vector for TICAM2
     GenScript Custom Assay Services for TICAM2 GenScript Custom overexpressing Cell Line Services for TICAM2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TICAM2 (TCAM2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TICAM2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TICAM2 antibodies
     TICAM2 proteins
     TICAM2 lysates
     Antibodies for TICAM2
     See all of Abcam's Antibodies, Kits and Proteins for TICAM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TICAM2
     Proteins for TICAM2
     Antibodies for TICAM2
     ELISAs for TICAM2
     CLIAs for TICAM2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TICAM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM2
     SwitchGear 3'UTR luciferase reporter plasmids for TICAM2
     SwitchGear Promoter luciferase reporter plasmids for TICAM2
     ThermoFisher Antibodies for TICAM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TICAM2
     Browse compounds at ApexBio
     Addgene plasmids for TICAM2
      Search eBioscience for proteins for TICAM2
      Search eBioscience for elisas for TICAM2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TICAM2
     antibodies-online antibodies for TICAM2 (71 products)
     antibodies-online kits for TICAM2 (6 products)
     antibodies-online peptides for TICAM2
     antibodies-online proteins for TICAM2 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TICAM2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4