Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TICAM2 Gene

protein-coding   GIFtS: 56
GCID: GC05M114942

Toll-Like Receptor Adaptor Molecule 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Toll-Like Receptor Adaptor Molecule 21 2     Cytoplasmic Adaptor2
TIRP2 3 5     NF-Kappa-B-Activating Protein 5022
TRAM2 3 5     TIR Domain-Containing Adapter Molecule 22
Putative NF-Kappa-B-Activating Protein 5022 3     Toll/Interleukin-1 Receptor (TIR) Domain-Containing Adapter Protein2
Toll-Like Receptor Adaptor Protein 32 3     TRIF-Related Adaptor Molecule2
MyD88-42 3     Toll/Interleukin-1 Receptor Domain-Containing Protein3
TICAM-22 3     TRIF-Related Adapter Molecule3
TIRAP32 3     

External Ids:    HGNC: 213541   Entrez Gene: 3533762   Ensembl: ENSG000002434147   OMIM: 6083215   UniProtKB: Q86XR73   

Export aliases for TICAM2 gene to outside databases

Previous GC identifers: GC00U917008 GC05M110096


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TICAM2 Gene:
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll
receptor signaling (see TLR4; MIM 603030).(supplied by OMIM, Apr 2004)

GeneCards Summary for TICAM2 Gene: 
TICAM2 (toll-like receptor adaptor molecule 2) is a protein-coding gene. Diseases associated with TICAM2 include progressive multifocal leukoencephalopathy, and vaccinia, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7
Function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the
innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to
TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in
IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are
controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18
signaling during adaptive immune response
Function: Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1
thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late
endosomes

Gene Wiki entry for TICAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TICAM2 gene promoter:
         STAT1   HOXA3   AML1a   GCNF   AREB6   GCNF-1   FOXO4   ZID   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTICAM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TICAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TICAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22.3

TICAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TICAM2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M114942:  view genomic region     (about GC identifiers)

Start:
114,914,339 bp from pter      End:
114,961,876 bp from pter
Size:
47,538 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7 (See protein sequence)
Recommended Name: TIR domain-containing adapter molecule 2  
Size: 235 amino acids; 26916 Da
Subunit: Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP,
IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts
with isoform 2; the interaction occurs in late endosomes and disrupts the interaction between isoform 1 and
TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in a time-dependent manner.
Interacts with IL18R1 and IL18RAP
Subcellular location: Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome
membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation.
Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform
2 in late endosomes
Subcellular location: Isoform 2: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane.
Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1
Secondary accessions: B3Y698 Q6JUT2
Alternative splicing: 2 isoforms:  Q86XR7-1   Q86XR7-2   

Explore the universe of human proteins at neXtProt for TICAM2: NX_Q86XR7

Explore proteomics data for TICAM2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the
    membrane upon phosphorylation
  • UniProtKB: Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate
    efficient signaling
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86XR7

  • TICAM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TICAM2 Protein Expression
    REFSEQ proteins: NP_067681.1  
    ENSEMBL proteins: 
     ENSP00000415139   ENSP00000386341  
    Reactome Protein details: Q86XR7
    Human Recombinant Protein Products for TICAM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TICAM2
    OriGene Protein Over-expression Lysate for TICAM2
    OriGene MassSpec for TICAM2 
    OriGene Custom Protein Services for TICAM2
    GenScript Custom Purified and Recombinant Proteins Services for TICAM2
    Novus Biologicals TICAM2 Proteins
    Novus Biologicals TICAM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TICAM2
    Cloud-Clone Corp. Proteins for TICAM2 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA--
    GO:0005770late endosome IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--

    TICAM2 for ontologies           About GeneDecksing



    TICAM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TICAM2
    R&D Systems Antibodies for TICAM2 (TRAM/TICAM2)
    OriGene Antibodies for TICAM2
    OriGene Custom Antibody Services for TICAM2
    GenScript Custom Superior Antibodies Services for TICAM2
    Novus Biologicals TICAM2 Antibodies
    Abcam antibodies for TICAM2
    Cloud-Clone Corp. Antibodies for TICAM2 
    ThermoFisher Antibodies for TICAM2
    LSBio Antibodies in human, mouse, rat for TICAM2 

    Assay Products for TICAM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TICAM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TICAM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TICAM2 
    Cloud-Clone Corp. CLIAs for TICAM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000157 TIR_dom

    Graphical View of Domain Structure for InterPro Entry Q86XR7

    ProtoNet protein and cluster: Q86XR7

    UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7
    Domain: The TIR domain mediates the interaction with TRAF6 and MYD88
    Similarity: Contains 1 TIR domain


    TICAM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAM2_HUMAN, Q86XR7
    Function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the
    innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to
    TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in
    IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are
    controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18
    signaling during adaptive immune response
    Function: Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1
    thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late
    endosomes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding ----
         
    TICAM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ticam2):
     immune system 

    TICAM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TICAM2: Ticam2tm1Aki Ticam2tm1Btlr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TICAM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TICAM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TICAM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TICAM2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TICAM2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TICAM2 (see all 9):
    hsa-miR-4307 hsa-miR-27a hsa-miR-513a-5p hsa-miR-298 hsa-miR-1303 hsa-miR-186 hsa-miR-580 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTICAM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TICAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TICAM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TICAM2
    Sirion Biotech Customized adenovirus for overexpression of TICAM2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TICAM2 (see all 7)
    OriGene ORF clones in mouse, rat for TICAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TICAM2 (NM_021649)
    Sino Biological Human cDNA Clone for TICAM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TICAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TICAM2
    Sirion Biotech Customized lentivirus for stable overexpression of TICAM2 
                         Customized lentivirus expression plasmids for stable overexpression of TICAM2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TICAM2
    Search LifeMap BioReagents cell lines for TICAM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TICAM2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    3TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    4TRAF6 mediated induction of TAK1 complex
    TRAF6 mediated induction of TAK1 complex0.56
    IKK complex recruitment mediated by RIP10.42
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon0.50
    TRIF-mediated programmed cell death0.32
    5Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TICAM2
        Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    2 R&D Systems Pathways for TICAM2
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways


    1 GeneGo (Thomson Reuters) Pathway for TICAM2
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    2 BioSystems Pathways for TICAM2
        Toll-like receptor signaling pathway
    IL1-mediated signaling events


    5/12        Reactome Pathways for TICAM2 (see all 12)
        IKK complex recruitment mediated by RIP1
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    TRIF-mediated programmed cell death
    Toll Like Receptor 3 (TLR3) Cascade


    4         Kegg Pathways  (Kegg details for TICAM2):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Pertussis
    Hepatitis B


    TICAM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TICAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/27 Interacting proteins for TICAM2 (Q86XR73 ENSP000003863414) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1R1P147783, ENSP000002339464I2D: score=3 STRING: ENSP00000233946
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=2 STRING: ENSP00000072516
    IRAK3Q9Y6163, ENSP000002612334I2D: score=2 STRING: ENSP00000261233
    TICAM1Q8IUC63, ENSP000002482444I2D: score=2 STRING: ENSP00000248244
    TIRAPP587533, ENSP000003764454I2D: score=2 STRING: ENSP00000376445
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006810transport ----
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    TICAM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TICAM2 (TCAM2)

    Search CenterWatch for drugs/clinical trials and news about TICAM2 / TCAM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TICAM2 gene: 
    NM_021649.6  

    Unigene Cluster for TICAM2:

    Toll-like receptor adaptor molecule 2
    Hs.718838  [show with all ESTs]
    Unigene Representative Sequence: NM_181836
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427199(uc003krc.3) ENST00000513729 ENST00000408996(uc003kre.3 uc003krd.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TICAM2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TICAM2 (see all 9):
    hsa-miR-4307 hsa-miR-27a hsa-miR-513a-5p hsa-miR-298 hsa-miR-1303 hsa-miR-186 hsa-miR-580 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTICAM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TICAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TICAM2
    Clone
    Products:
         
    OriGene clones in human, mouse for TICAM2 (see all 7)
    OriGene ORF clones in mouse, rat for TICAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TICAM2 (NM_021649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TICAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TICAM2
    Sirion Biotech Customized lentivirus for stable overexpression of TICAM2 
                         Customized lentivirus expression plasmids for stable overexpression of TICAM2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TICAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for TICAM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TICAM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TICAM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TICAM2

    Additional mRNA sequence: 

    AB002442.1 AB002444.1 AB091054.1 AB097022.1 AB109098.1 AB446491.1 AK027512.1 AK074962.1 
    AK304210.1 AY232653.1 AY304582.1 BC019349.2 BC107426.1 BC109265.2 BC109266.2 

    19 DOTS entries:

    DT.91706620  DT.317427  DT.102829506  DT.100682969  DT.91756295  DT.100794712  DT.407654  DT.86847868 
    DT.120852761  DT.120852749  DT.407653  DT.75199754  DT.95134689  DT.92419987  DT.120852775  DT.120852782 
    DT.444446  DT.95134675  DT.95134717 

    24/366 AceView cDNA sequences (see all 366):

    AA382927 AA627524 CN479117 AW513039 CB122425 AA427692 CA867704 AA460222 
    AI537661 BM720603 BQ639833 AW510525 AA918130 AB097022 AI687414 AK075218 
    BE274946 AY304583 AA427693 AA677458 BE673298 AW514768 AY275836 AA476468 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TICAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATATGTA
    TICAM2 Expression
    About this image


    See TICAM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TICAM2

    SOURCE GeneReport for Unigene cluster: Hs.718838

    UniProtKB/Swiss-Prot: TCAM2_HUMAN, Q86XR7
    Tissue specificity: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood
    leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at
    lower levels than isoform 1)

        SABiosciences Expression via Pathway-Focused PCR Arrays including TICAM2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TICAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for TICAM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TICAM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TICAM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TICAM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TICAM2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ticam21 , 5 toll-like receptor adaptor molecule 21, 5 78.59(n)1
    75.43(a)1
      18 (24.65 cM)5
    2254711  NM_173394.31  NP_775570.11 
     465591555 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    40(a)
    possible ortholog
    GL343193.1(8301237-8313846)
    zebrafish
    (Danio rerio)
    Actinopterygii tmed76
    transmembrane emp24 protein transport domain conta...
    69(a)
    1 → many
    8(442391-447707)
    fruit fly
    (Drosophila melanogaster)
    Insecta p24-16
    p24-related-1
    42(a)
    1 → many
    X(11745364-11746548)
    worm
    (Caenorhabditis elegans)
    Secernentea F57B10.56
    Protein F57B10.5
    47(a)
    1 → many
    I(6562697-6563660)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMP246
    Component of the p24 complex; binds to GPI anchor ...
    21(a)
    1 → many
    VII(122694-123305)


    ENSEMBL Gene Tree for TICAM2 (if available)
    TreeFam Gene Tree for TICAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TICAM2 gene
    TMED52  TMED12  TMED7-TICAM22  TMED22  TMED32  TMED72  

    TICAM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TICAM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830455CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TICAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for TICAM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608321    OMIM disorders: --

    5 diseases for TICAM2:    About MalaCards
    progressive multifocal leukoencephalopathy    vaccinia    pertussis    lung cancer
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for TICAM2:
    Retinoblastoma     Progressive multifocal leukoencephalopathy

    TICAM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TICAM2
    Human Genome Epidemiology (HuGE) Navigator: TICAM2 (3 documents)

    Export disorders for TICAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TICAM2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with TICAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PubMed id 12721283)1, 2, 9 Bin L.H.... Shu H.B. (2003)
    2. TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. (PubMed id 22685567)1, 2 Ohnishi H....Kondo N. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Toll-like receptor polymorphisms and susceptibility t o urinary tract infections in adult women. (PubMed id 19543401)1, 4 Hawn T.R....Hooton T.M. (2009)
    5. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2 Nakajima T....Kimura A. (2008)
    6. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. (PubMed id 16603631)1, 2 Rowe D.C.... Golenbock D.T. (2006)
    7. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. (PubMed id 14517278)1, 2 Fitzgerald K.A.... Golenbock D.T. (2003)
    8. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (2003)
    9. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon- beta. (PubMed id 14519765)1, 2 Oshiumi H.... Seya T. (2003)
    10. Human cytomegalovirus induces TLR4 signaling component s in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-alpha expression. (PubMed id 22970235)1 Yew K.H....Harrison C.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353376 HGNC: 21354 AceView: TICAM2andCGI-109 Ensembl:ENSG00000243414 euGenes: HUgn353376
    ECgene: TICAM2 Kegg: 353376 H-InvDB: TICAM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TICAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TICAM2 gene:
    Search GeneIP for patents involving TICAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TICAM2
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TICAM2 (TRAM/TICAM2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TICAM2   OriGene RNAi products in human, mouse, rat for TICAM2  
     OriGene qPCR primer pairs and template standards for TICAM2   OriGene Protein Over-expression Lysate for TICAM2  
     OriGene MassSpec something-or-other for TICAM2   OriGene clones in human, mouse for TICAM2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TICAM2   OriGene Purified Protein for TICAM2  
     OriGene ORF clones in mouse, rat for TICAM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TICAM2   OriGene Custom Protein Services for TICAM2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TICAM2
     QIAGEN SeqTarget long-range PCR primers for resequencing TICAM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TICAM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TICAM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TICAM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TICAM2
     GenScript Custom Purified and Recombinant Proteins Services for TICAM2 GenScript cDNA clones with any tag delivered in your preferred vector for TICAM2
     GenScript Custom Assay Services for TICAM2 GenScript Custom Superior Antibodies Services for TICAM2
     GenScript Custom overexpressing Cell Line Services for TICAM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TICAM2 promoter
     Search Chromatin IP Primers for TICAM2
     RT2 qPCR Primer Assay in human, mouse, rat TICAM2
     GNC Network for TICAM2
     SABiosciences PCR Arrays including human, mouse, rat TICAM2
     Search Tocris compounds for TICAM2 (TCAM2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for TICAM2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TICAM2 antibodies
     TICAM2 proteins
     TICAM2 lysates
     Antibodies for TICAM2
     See all of Abcam's Antibodies, Kits and Proteins for TICAM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TICAM2




     Proteins for TICAM2
     Antibodies for TICAM2
     ELISAs for TICAM2
     CLIAs for TICAM2
     Search LifeMap BioReagents cell lines for TICAM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM2
     SwitchGear 3'UTR luciferase reporter plasmids for TICAM2
     SwitchGear Promoter luciferase reporter plasmids for TICAM2
     ThermoFisher Antibodies for TICAM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TICAM2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TICAM2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TICAM2
    Customized:
     lentivirus for stable overexpression of TICAM2
     lentivirus expression plasmids for stable overexpression of TICAM2
     adenovirus for overexpression of TICAM2
     LSBio Antibodies in human, mouse, rat for TICAM2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TICAM2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4