Aliases for TICAM1 Gene
- Toll-Like Receptor Adaptor Molecule 1 2 3
- Trif 3 4 6
- Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta 3 4
- Proline-Rich, Vinculin And TIR Domain-Containing Protein B 3 4
- TIR Domain-Containing Adapter Protein Inducing IFN-Beta 3 4
- Putative NF-Kappa-B-Activating Protein 502H 3 4
- MyD88-3 3 4
External Ids for TICAM1 Gene
Previous GeneCards Identifiers for TICAM1 Gene
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
GeneCards Summary for TICAM1 Gene
TICAM1 (Toll-Like Receptor Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with TICAM1 include encephalopathy, acute, infection-induced 6 and herpes simplex encephalitis. Among its related pathways are Hepatitis C and Influenza A. GO annotations related to this gene include protein kinase binding and signal transducer activity.
UniProtKB/Swiss-Prot for TICAM1 Gene
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.