Aliases for TICAM1 Gene
- Toll Like Receptor Adaptor Molecule 1 2 3 5
- Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta 3 4
- Proline-Rich, Vinculin And TIR Domain-Containing Protein B 3 4
- TIR Domain-Containing Adapter Protein Inducing IFN-Beta 3 4
- Putative NF-Kappa-B-Activating Protein 502H 3 4
- TIR Domain-Containing Adapter Molecule 1 2 3
- MyD88-3 3 4
External Ids for TICAM1 Gene
Previous GeneCards Identifiers for TICAM1 Gene
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
GeneCards Summary for TICAM1 Gene
TICAM1 (Toll Like Receptor Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with TICAM1 include Herpes Simplex Encephalitic 6 and Herpes Simplex Encephalitis Susceptibility 6. Among its related pathways are Activated TLR4 signalling and Diseases of Immune System. GO annotations related to this gene include protein kinase binding and signal transducer activity. An important paralog of this gene is TMED7-TICAM2.
UniProtKB/Swiss-Prot for TICAM1 Gene
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.