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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TICAM1 Gene

protein-coding   GIFtS: 59
GCID: GC19M004815

Toll-Like Receptor Adaptor Molecule 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Toll-Like Receptor Adaptor Molecule 11 2     PRVTIRB2 3
TRIF2 3 5     TICAM-12 3
Proline-Rich, Vinculin And TIR Domain-Containing Protein B2 3     TIR Domain-Containing Adapter Protein Inducing IFN-Beta2 3
Putative NF-Kappa-B-Activating Protein 502H2 3     IIAE62
Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing
Interferon Beta2 3
     TIR Domain Containing Adaptor Inducing Interferon-Beta2
MyD88-32 3     TIR Domain-Containing Adapter Molecule 12

External Ids:    HGNC: 183481   Entrez Gene: 1480222   Ensembl: ENSG000001276667   OMIM: 6076015   UniProtKB: Q8IUC63   

Export aliases for TICAM1 gene to outside databases

Previous GC identifers: GC19M004767 GC19M004577


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TICAM1 Gene:
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an
intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs)
and signal-transduction components. This protein is involved in native immunity against invading pathogens. It
specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA
induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
(provided by RefSeq, Jan 2012)

GeneCards Summary for TICAM1 Gene: 
TICAM1 (toll-like receptor adaptor molecule 1) is a protein-coding gene. Diseases associated with TICAM1 include herpes simplex encephalitis 4, and herpes simplex encephalitis, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways. GO annotations related to this gene include protein kinase binding and signal transducer activity.

UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
Function: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2)
to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding
to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow
recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of
transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TICAM1 gene promoter:
         CRE-BP1   Tal-1   ATF-2   NF-kappaB   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTICAM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TICAM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TICAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TICAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TICAM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004815:  view genomic region     (about GC identifiers)

Start:
4,815,938 bp from pter      End:
4,831,737 bp from pter
Size:
15,800 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6 (See protein sequence)
Recommended Name: TIR domain-containing adapter molecule 1  
Size: 712 amino acids; 76422 Da
Subunit: Homodimer (Probable). Interacts (via the TIR domain) with TLR3; mediates TLR3 signaling. Interacts with
AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the
TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1
blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3 (By similarity). Interacts with
TRAF6. Interacts with TRAFD1 (By similarity)
Sequence caution: Sequence=AAO85488.1; Type=Frameshift; Positions=141, 148, 161;
1 PDB 3D structure from and Proteopedia for TICAM1:
3RC4 (3D)    
Secondary accessions: B3Y691 O75532 Q86XP8 Q96GA0

Explore the universe of human proteins at neXtProt for TICAM1: NX_Q8IUC6

Explore proteomics data for TICAM1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by TBK1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IUC6

  • TICAM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TICAM1 Protein Expression
    REFSEQ proteins: NP_891549.1  
    ENSEMBL proteins: 
     ENSP00000248244  
    Reactome Protein details: Q8IUC6
    Human Recombinant Protein Products for TICAM1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TICAM1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    TICAM1 for ontologies           About GeneDecksing



    TICAM1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR025735 RHIM_dom
     IPR017278 Tol-interleuk_rcpt_adapt_Ticam

    Graphical View of Domain Structure for InterPro Entry Q8IUC6

    ProtoNet protein and cluster: Q8IUC6

    UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
    Domain: The N-terminal region is essential for activation of the IFNB promoter activity
    Similarity: Contains 1 TIR domain


    TICAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAM1_HUMAN, Q8IUC6
    Function: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2)
    to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding
    to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow
    recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of
    transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI14982987
    GO:0019901protein kinase binding IPI14530355
         
    TICAM1 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ticam1):
     cardiovascular system  cellular  digestive/alimentary  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  tumorigenesis  vision/eye 

    TICAM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TICAM1: Ticam1tm1Aki Ticam1tm1Tsse

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TICAM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TICAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TICAM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TICAM1 

    miRNA
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    miRTarBase miRNAs that target TICAM1:
    hsa-mir-221 (MIRT005475)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TICAM1
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TICAM1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    2Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    3TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    4TRAF6 mediated induction of TAK1 complex
    TRAF6 mediated induction of TAK1 complex0.56
    IKK complex recruitment mediated by RIP10.42
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon0.50
    TRIF-mediated programmed cell death0.32
    5Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TICAM1
        Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    2 R&D Systems Pathways for TICAM1
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for TICAM1
        NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for TICAM1
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    1 BioSystems Pathway for TICAM1
        Toll-like receptor signaling pathway

    5/12        Reactome Pathways for TICAM1 (see all 12)
        IKK complex recruitment mediated by RIP1
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    TRIF-mediated programmed cell death
    Toll Like Receptor 3 (TLR3) Cascade


    5/8         Kegg Pathways  (Kegg details for TICAM1) (see all 8):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Pertussis
    Chagas disease (American trypanosomiasis)
    Hepatitis C


    TICAM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TICAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for TICAM1 (Q8IUC62, 3 ENSP000002482444) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIAS4Q8N2W92, 3, ENSP000002629714MINT-50621 I2D: score=3 STRING: ENSP00000262971
    TNFAIP3P215802, 3, ENSP000002372894MINT-50566 I2D: score=4 STRING: ENSP00000237289
    TBK1Q9UHD23, ENSP000003299674I2D: score=6 STRING: ENSP00000329967
    IRF7Q929853, ENSP000003294114I2D: score=3 STRING: ENSP00000329411
    TANKQ928443, ENSP000002590754I2D: score=3 STRING: ENSP00000259075
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002281macrophage activation involved in immune response IEA--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006915apoptotic process ----
    GO:0006954inflammatory response IEA--

    TICAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TICAM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TICAM1 (TCAM1)

    3 Novoseek inferred chemical compound relationships for TICAM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 78.4 3 15737993 (1), 16849320 (1)
    rantes 49.8 1 18282411 (1)
    serine 0 2 17651439 (1), 19353241 (1)

    Search CenterWatch for drugs/clinical trials and news about TICAM1 / TCAM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TICAM1 gene (2 alternative transcripts): 
    NM_182919.3  NM_014261.1  

    Unigene Cluster for TICAM1:

    Toll-like receptor adaptor molecule 1
    Hs.29344  [show with all ESTs]
    Unigene Representative Sequence: BC035331
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248244(uc002mbi.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB086380.1 AB093555.1 AB097023.1 AB446484.1 AF070530.1 BC009860.2 BC035331.1 BC136556.1 
    BC136557.1 

    4 DOTS entries:

    DT.213492  DT.95107436  DT.95262570  DT.95363392 

    24/106 AceView cDNA sequences (see all 106):

    BQ772589 AF070530 AB086380 AW138109 CD367514 BM763771 AA926989 CR592986 
    CA443266 CA308725 AB093555 NM_182919 AB097023 AA357024 BM550597 CD365233 
    BQ684287 BU173884 CF242882 AI560708 BF115568 BG027767 BX356785 BM562157 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TICAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAACCAGA
    TICAM1 Expression
    About this image


    See TICAM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TICAM1

    SOURCE GeneReport for Unigene cluster: Hs.29344

    UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
    Tissue specificity: Ubiquitously expressed but with higher levels in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including TICAM1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TICAM1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ticam11 , 5 toll-like receptor adaptor molecule 11, 5 67.79(n)1
    59.36(a)1
      17 (29.24 cM)5
    1067591  NM_174989.41  NP_778154.11 
     562693195 
    chicken
    (Gallus gallus)
    Aves TICAM11 toll-like receptor adaptor molecule 1 45.87(n)
    36.68(a)
      100008585  NM_001081506.1  NP_001074975.1 
    lizard
    (Anolis carolinensis)
    Reptilia TICAM16
    toll-like receptor adaptor molecule 1
    26(a)
    1 ↔ 1
    GL343661.1(279017-281200)
    zebrafish
    (Danio rerio)
    Actinopterygii ticam11 toll-like receptor adaptor molecule 1 42.91(n)
    34.46(a)
      403147  NM_001044759.1  NP_001038224.1 


    ENSEMBL Gene Tree for TICAM1 (if available)
    TreeFam Gene Tree for TICAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/541 SNPs in TICAM1 are shown (see all 541)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0387894
    A breast cancer sample4--see VAR_0387892 M I mis40--------
    rs1465504891,2,4
    C,FHerpes simplex encephalitis 4 (HSE4)4 --4817833(+) AGTCCG/AAAACA 2 /S /L mis12Minor allele frequency- A:0.00NA EU 5431
    rs343927351,2
    F--4815467(+) CACTCA/G/TCTCAC 1 -- ds50012NA 8
    rs602522111,2
    C--4815473(+) TTCATTCAT/-  
            
    AGCTC
    1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs621160761,2
    F--4815476(+) ACTCAC/TTCATT 1 -- ds50012Minor allele frequency- T:0.50NA CSA 4
    rs114667271,2
    C,F--4815486(-) TGAATG/TAATGA 1 -- ds50013Minor allele frequency- T:0.01NA EU 84
    rs2009169891,2
    C--4815715(+) CTCGGA/GAGGCA 1 -- ds50010--------
    rs1812073041,2
    --4815720(+) GAGGCA/TCACGG 1 -- ds50010--------
    rs1179750271,2
    F--4815753(+) CCCAGG/AGTTCC 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs104197131,2
    C,F,H--4815810(+) gagggC/Taaagg 1 -- ds50018Minor allele frequency- T:0.03NS EA NA EU WA 630

    HapMap Linkage Disequilibrium report for TICAM1 (4815938 - 4831737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TICAM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv910847CNV Loss21882294
    nsv910859CNV Loss21882294
    nsv470117CNV Loss18288195


    Human Gene Mutation Database (HGMD): TICAM1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TICAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for TICAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607601    OMIM disorders: --

    UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
  • Herpes simplex encephalitis 4 (HSE4) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1)
    infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic
    necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache,
    seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 20/28 diseases for TICAM1 (see all 28):    About MalaCards
    herpes simplex encephalitis 4    herpes simplex encephalitis    cellulitis    hepatitis a
    trypanosomiasis    herpes simplex    chagas disease    dengue hemorrhagic fever
    kawasaki disease    hemorrhagic fever    synovitis    encephalitis
    pertussis    headache    kaposi's sarcoma    vitiligo
    hepatitis c    meningioma    hepatitis    influenza


    TICAM1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TICAM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 23.7 2 14739303 (1), 14960149 (1)
    melanoma 17 1 19353241 (1)
    tumors 0 2 14739303 (1), 19898473 (1)

    Genetic Association Database (GAD): TICAM1
    Human Genome Epidemiology (HuGE) Navigator: TICAM1 (11 documents)

    Export disorders for TICAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TICAM1 gene, integrated from 9 sources (see all 149):
    (articles sorted by number of sources associating them with TICAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. (PubMed id 12471095)1, 2, 3, 9 Yamamoto M....Akira S. (2002)
    2. TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction. (PubMed id 12539043)1, 2, 3 Oshiumi H.... Seya T. (2003)
    3. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. (PubMed id 14530355)1, 2, 9 Sato S....Akira S. (2003)
    4. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN- beta. (PubMed id 14982987)1, 2, 9 Jiang Z.... Li X. (2004)
    5. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PubMed id 14739303)1, 2, 9 Han K.J.... Shu H.-B. (2004)
    6. The human adaptor SARM negatively regulates adaptor protein TRIF- dependent Toll-like receptor signaling. (PubMed id 16964262)1, 2, 9 Carty M....Bowie A.G. (2006)
    7. NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PubMed id 15611223)1, 2, 9 Sasai M....Seya T. (2005)
    8. Herpes simplex encephalitis in children with autosoma l recessive and dominant TRIF deficiency. (PubMed id 22105173)1, 2 Sancho-Shimizu V....Casanova J.L. (2011)
    9. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    10. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 148022 HGNC: 18348 AceView: TRIF Ensembl:ENSG00000127666 euGenes: HUgn148022
    ECgene: TICAM1 Kegg: 148022 H-InvDB: TICAM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TICAM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TICAM1 gene:
    Search GeneIP for patents involving TICAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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