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TICAM1 Gene

protein-coding   GIFtS: 57
GCID: GC19M004815

Toll-Like Receptor Adaptor Molecule 1

  See TICAM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Toll-Like Receptor Adaptor Molecule 11 2     PRVTIRB2 3
TRIF2 3 5     TICAM-12 3
Proline-Rich, Vinculin And TIR Domain-Containing Protein B2 3     TIR Domain-Containing Adapter Protein Inducing IFN-Beta2 3
Putative NF-Kappa-B-Activating Protein 502H2 3     IIAE62 5
Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing
Interferon Beta2 3
     TIR Domain Containing Adaptor Inducing Interferon-Beta2
MyD88-32 3     TIR Domain-Containing Adapter Molecule 12

External Ids:    HGNC: 183481   Entrez Gene: 1480222   Ensembl: ENSG000001276667   OMIM: 6076015   UniProtKB: Q8IUC63   

Export aliases for TICAM1 gene to outside databases

Previous GC identifers: GC19M004767 GC19M004577


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TICAM1 Gene:
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an
intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs)
and signal-transduction components. This protein is involved in native immunity against invading pathogens. It
specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA
induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
(provided by RefSeq, Jan 2012)

GeneCards Summary for TICAM1 Gene:
TICAM1 (toll-like receptor adaptor molecule 1) is a protein-coding gene. Diseases associated with TICAM1 include encephalopathy, acute, infection-induced 6, and herpes simplex encephalitis 1. GO annotations related to this gene include protein kinase binding and signal transducer activity.

UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
Function: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2)
to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding
to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow
recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of
transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TICAM1 gene promoter:
         CRE-BP1   Tal-1   ATF-2   NF-kappaB   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTICAM1 promoter sequence
   Search Chromatin IP Primers for TICAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TICAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TICAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TICAM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004815:  view genomic region     (about GC identifiers)

Start:
4,815,938 bp from pter      End:
4,831,737 bp from pter
Size:
15,800 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6 (See protein sequence)
Recommended Name: TIR domain-containing adapter molecule 1  
Size: 712 amino acids; 76422 Da
Subunit: Homodimer (Probable). Interacts (via the TIR domain) with TLR3; mediates TLR3 signaling. Interacts with
AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the
TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1
blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3 (By similarity). Interacts with
TRAF6. Interacts with TRAFD1 (By similarity)
Sequence caution: Sequence=AAO85488.1; Type=Frameshift; Positions=141, 148, 161;
4 PDB 3D structures from and Proteopedia for TICAM1:
2M1X (3D)        3RC4 (3D)        4BSX (3D)        4C0M (3D)    
Secondary accessions: B3Y691 O75532 Q86XP8 Q96GA0

Explore the universe of human proteins at neXtProt for TICAM1: NX_Q8IUC6

Explore proteomics data for TICAM1 at MOPED

Post-translational modifications: 

  • Phosphorylated by TBK11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TICAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_891549.1  
    ENSEMBL proteins: 
     ENSP00000248244  
    Reactome Protein details: Q8IUC6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR025735 RHIM_dom
     IPR000157 TIR_dom
     IPR017278 TICAM1

    Graphical View of Domain Structure for InterPro Entry Q8IUC6

    ProtoNet protein and cluster: Q8IUC6

    UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
    Domain: The N-terminal region is essential for activation of the IFNB promoter activity
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TICAM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAM1_HUMAN, Q8IUC6
    Function: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2)
    to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding
    to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow
    recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of
    transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI14982987
    GO:0019901protein kinase binding IPI14530355
         
    Find genes that share ontologies with TICAM1           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ticam1):
     cardiovascular system  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with TICAM1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TICAM1: Ticam1tm1Aki Ticam1tm1Tsse

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TICAM1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TICAM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TICAM1

    miRNA
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    miRTarBase miRNAs that target TICAM1:
    hsa-mir-193b-3p (MIRT041391), hsa-mir-221-3p (MIRT005475)

    Block miRNA regulation of human, mouse, rat TICAM1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TICAM1
    SwitchGear 3'UTR luciferase reporter plasmidTICAM1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for TICAM1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    plasma membrane2
    lysosome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--
    GO:0097342ripoptosome IDA--

    Find genes that share ontologies with TICAM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TICAM1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    Inflammasome Activation Pathways0.51
    3Cytosolic sensors of pathogen-associated DNA
    RIP-mediated NFkB activation via ZBP10.81
    Cytosolic sensors of pathogen-associated DNA0.38
    ZBP1(DAI) mediated induction of type I IFNs0.81
    4Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    TRIF-mediated programmed cell death0.00
    Toll Like Receptor 3 (TLR3) Cascade0.69
    5Influenza A
    Influenza A0.34
    Herpes simplex infection0.33


    Find genes that share SuperPaths with TICAM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TICAM1
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TICAM1
        Toll-Like Receptors Pathway
    TLR-TRIF Pathway

    1 Cell Signaling Technology (CST) Pathway for TICAM1
        NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for TICAM1
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    2 BioSystems Pathways for TICAM1
        Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway

    Selected Reactome Pathways for TICAM1 (see all 6)
        IKK complex recruitment mediated by RIP1
    TRIF-mediated programmed cell death
    MyD88-independent cascade
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
    RIP-mediated NFkB activation via ZBP1


    Selected Kegg Pathways  (Kegg details for TICAM1) (see all 8):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    Pertussis
    Chagas disease (American trypanosomiasis)
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TICAM1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TICAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TICAM1 (Q8IUC62, 3 ENSP000002482444) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIAS4Q8N2W92, 3, ENSP000002629714MINT-50621 I2D: score=3 STRING: ENSP00000262971
    TNFAIP3P215802, 3, ENSP000002372894MINT-50566 I2D: score=4 STRING: ENSP00000237289
    TBK1Q9UHD23, ENSP000003299674I2D: score=6 STRING: ENSP00000329967
    IRF7Q929853, ENSP000003294114I2D: score=3 STRING: ENSP00000329411
    TANKQ928443, ENSP000002590754I2D: score=3 STRING: ENSP00000259075
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    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002281macrophage activation involved in immune response IEA--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    Find genes that share ontologies with TICAM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TICAM1 (TCAM1)

    3 Novoseek inferred chemical compound relationships for TICAM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 78.4 3 15737993 (1), 16849320 (1)
    rantes 49.8 1 18282411 (1)
    serine 0 2 17651439 (1), 19353241 (1)



    Find genes that share compounds with TICAM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TICAM1 gene (2 alternative transcripts): 
    NM_182919.3  NM_014261.1  

    Unigene Cluster for TICAM1:

    Toll-like receptor adaptor molecule 1
    Hs.29344  [show with all ESTs]
    Unigene Representative Sequence: BC035331
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248244(uc002mbi.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat TICAM1

    Additional mRNA sequence: 

    AB086380.1 AB093555.1 AB097023.1 AB446484.1 AF070530.1 BC009860.2 BC035331.1 BC136556.1 
    BC136557.1 

    4 DOTS entries:

    DT.213492  DT.95107436  DT.95262570  DT.95363392 

    Selected AceView cDNA sequences (see all 106):

    CA443266 NM_182919 AA926989 AB086380 AW138109 CR592986 AB093555 CF242882 
    BM763771 BU173884 CD365233 CA308725 AB097023 BQ684287 AA357024 CD367514 
    AF070530 BQ772589 BM550597 AA366190 AW006301 BM982298 BG753470 CA435274 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TICAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAACCAGA
    TICAM1 Expression
    About this image

    TICAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TICAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29344

    UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
    Tissue specificity: Ubiquitously expressed but with higher levels in liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TICAM1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TICAM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TICAM1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ticam11 , 5 toll-like receptor adaptor molecule 11, 5 66.47(n)1
    57.6(a)1
      17 (29.24 cM)5
    1067591  NM_174989.41  NP_778154.11 
     562693195 
    chicken
    (Gallus gallus)
    Aves TICAM16
    Gallus gallus toll-like receptor adaptor molecule ...
    30(a)
    1 ↔ 1
    28(4625272-4627738)
    lizard
    (Anolis carolinensis)
    Reptilia TICAM16
    toll-like receptor adaptor molecule 1
    28(a)
    1 ↔ 1
    GL343661.1(279017-281200)
    zebrafish
    (Danio rerio)
    Actinopterygii ticam16
    ticam16
    toll-like receptor adaptor molecule 1
    25(a)
    25(a)
    many → 1
    many → 1
    22(4117520-4120897) ENSDARG00000086136
    22(3850516-3853876) ENSDARG00000042714


    ENSEMBL Gene Tree for TICAM1 (if available)
    TreeFam Gene Tree for TICAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TICAM1 (see all 541)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465504891,2,,4
    C,FHerpes simplex encephalitis 4 (HSE4)4 --4817833(+) AGTCCG/AAAACA 2 /S /L mis12Minor allele frequency- A:0.00NA EU 5431
    VAR_0387894
    A breast cancer sample4--see VAR_0387892 M I mis40--------
    rs343927351,2
    F--4815467(+) CACTCA/G/TCTCAC 1 -- ds50012NA 8
    rs602522111,2
    C--4815473(+) TTCATTCAT/-  
            
    AGCTC
    1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs621160761,2
    F--4815476(+) ACTCAC/TTCATT 1 -- ds50012Minor allele frequency- T:0.50NA CSA 4
    rs114667271,2
    C,F--4815486(-) TGAATG/TAATGA 1 -- ds50013Minor allele frequency- T:0.01NA EU 84
    rs2009169891,2
    C--4815715(+) CTCGGA/GAGGCA 1 -- ds50010--------
    rs1812073041,2
    --4815720(+) GAGGCA/TCACGG 1 -- ds50010--------
    rs1179750271,2
    F--4815753(+) CCCAGG/AGTTCC 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs104197131,2
    C,F,H--4815810(+) gagggC/Taaagg 1 -- ds50018Minor allele frequency- T:0.03NS EA NA EU WA 630

    HapMap Linkage Disequilibrium report for TICAM1 (4815938 - 4831737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TICAM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910847CNV Loss21882294
    nsv910859CNV Loss21882294
    nsv470117CNV Loss18288195

    Human Gene Mutation Database (HGMD): TICAM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TICAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for TICAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607601   
    OMIM disorders: 614850  
    UniProtKB/Swiss-Prot: TCAM1_HUMAN, Q8IUC6
  • Herpes simplex encephalitis 4 (HSE4) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1)
    infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic
    necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache,
    seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 5 diseases for TICAM1:    
    About MalaCards
    encephalopathy, acute, infection-induced 6    herpes simplex encephalitis 1    herpes simplex encephalitis    herpes simplex
    encephalitis


    Find genes that share disorders with TICAM1           About GenesLikeMe

    3 Novoseek inferred disease relationships for TICAM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 23.7 2 14739303 (1), 14960149 (1)
    melanoma 17 1 19353241 (1)
    tumors 0 2 14739303 (1), 19898473 (1)

    Genetic Association Database (GAD): TICAM1
    Human Genome Epidemiology (HuGE) Navigator: TICAM1 (11 documents)

    Export disorders for TICAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TICAM1 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with TICAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. (PubMed id 12471095)1, 2, 3, 9 Yamamoto M....Akira S. (J. Immunol. 2002)
    2. TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction. (PubMed id 12539043)1, 2, 3 Oshiumi H.... Seya T. (Nat. Immunol. 2003)
    3. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. (PubMed id 14530355)1, 2, 9 Sato S....Akira S. (J. Immunol. 2003)
    4. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN- beta. (PubMed id 14982987)1, 2, 9 Jiang Z.... Li X. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PubMed id 14739303)1, 2, 9 Han K.J.... Shu H.-B. (J. Biol. Chem. 2004)
    6. The human adaptor SARM negatively regulates adaptor protein TRIF- dependent Toll-like receptor signaling. (PubMed id 16964262)1, 2, 9 Carty M....Bowie A.G. (Nat. Immunol. 2006)
    7. NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PubMed id 15611223)1, 2, 9 Sasai M....Seya T. (J. Immunol. 2005)
    8. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. (PubMed id 22105173)1, 2 Sancho-Shimizu V.... Casanova J.L. (J. Clin. Invest. 2011)
    9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 148022 HGNC: 18348 AceView: TRIF Ensembl:ENSG00000127666 euGenes: HUgn148022
    ECgene: TICAM1 Kegg: 148022 H-InvDB: TICAM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TICAM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TICAM1 gene:
    Search GeneIP for patents involving TICAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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