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Aliases for TICAM1 Gene

Aliases for TICAM1 Gene

  • Toll Like Receptor Adaptor Molecule 1 2 3 5
  • Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta 3 4
  • Proline-Rich, Vinculin And TIR Domain-Containing Protein B 3 4
  • TIR Domain-Containing Adapter Protein Inducing IFN-Beta 3 4
  • Putative NF-Kappa-B-Activating Protein 502H 3 4
  • MyD88-3 3 4
  • PRVTIRB 3 4
  • TICAM-1 3 4
  • TRIF 3 4
  • TIR Domain Containing Adaptor Inducing Interferon-Beta 3
  • TIR Domain-Containing Adapter Molecule 1 3
  • Toll-Like Receptor Adaptor Molecule 1 2
  • IIAE6 3

External Ids for TICAM1 Gene

Previous GeneCards Identifiers for TICAM1 Gene

  • GC19M004767
  • GC19M004577

Summaries for TICAM1 Gene

Entrez Gene Summary for TICAM1 Gene

  • This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]

GeneCards Summary for TICAM1 Gene

TICAM1 (Toll Like Receptor Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with TICAM1 include Herpes Simplex Encephalitic 6 and Herpes Simplex Encephalitis. Among its related pathways are Toll-Like receptor Signaling Pathways and MyD88 cascade initiated on plasma membrane. GO annotations related to this gene include protein kinase binding and signal transducer activity.

UniProtKB/Swiss-Prot for TICAM1 Gene

  • Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICAM1 Gene

Genomics for TICAM1 Gene

Regulatory Elements for TICAM1 Gene

Enhancers for TICAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TICAM1 on UCSC Golden Path with GeneCards custom track

Promoters for TICAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TICAM1 Gene

Chromosome:
19
Start:
4,815,924 bp from pter
End:
4,831,742 bp from pter
Size:
15,819 bases
Orientation:
Minus strand

Genomic View for TICAM1 Gene

Genes around TICAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TICAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TICAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICAM1 Gene

Proteins for TICAM1 Gene

  • Protein details for TICAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC6-TCAM1_HUMAN
    Recommended name:
    TIR domain-containing adapter molecule 1
    Protein Accession:
    Q8IUC6
    Secondary Accessions:
    • B3Y691
    • O75532
    • Q86XP8
    • Q96GA0

    Protein attributes for TICAM1 Gene

    Size:
    712 amino acids
    Molecular mass:
    76422 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with AZI2, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3 (By similarity). Interacts with TBK1, TRAF6 and RIPK1 and these interactions are enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TRAFD1 (By similarity). Interacts with UBQLN1 (via UBA domain). Interacts with TLR4 in response to LPS in a WDFY1-dependent manner (By similarity). Interacts with WDFY1 in response to poly(I:C) (By similarity). Interacts (via the TIR domain) with TLR3 in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436).
    SequenceCaution:
    • Sequence=AAO85488.1; Type=Frameshift; Positions=141, 148, 161; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TICAM1 Gene

neXtProt entry for TICAM1 Gene

Post-translational modifications for TICAM1 Gene

Other Protein References for TICAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TICAM1 (TICAM1)
  • Cloud-Clone Corp. Antibodies for TICAM1

No data available for DME Specific Peptides for TICAM1 Gene

Domains & Families for TICAM1 Gene

Gene Families for TICAM1 Gene

Protein Domains for TICAM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TICAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IUC6

UniProtKB/Swiss-Prot:

TCAM1_HUMAN :
  • The N-terminal region is essential for activation of the IFNB promoter activity.
Domain:
  • The N-terminal region is essential for activation of the IFNB promoter activity.
  • The N-terminal domain (TRIF-NTD) is globular and consists of two alpha-helical subdomains connected by a 14-residue linker. It shares structural similarity with IFIT family members N-terminal regions.
  • Contains 1 TIR domain.
genes like me logo Genes that share domains with TICAM1: view

Function for TICAM1 Gene

Molecular function for TICAM1 Gene

UniProtKB/Swiss-Prot Function:
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Gene Ontology (GO) - Molecular Function for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IEA,IPI 14982987
GO:0019901 protein kinase binding IPI 14530355
genes like me logo Genes that share ontologies with TICAM1: view
genes like me logo Genes that share phenotypes with TICAM1: view

Human Phenotype Ontology for TICAM1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TICAM1 Gene

MGI Knock Outs for TICAM1:

Animal Model Products

CRISPR Products

miRNA for TICAM1 Gene

miRTarBase miRNAs that target TICAM1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TICAM1 Gene

Localization for TICAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICAM1 Gene

Cytoplasmic vesicle, autophagosome. Note=Colocalizes with UBQLN1 in the autophagosome. {ECO:0000269 PubMed:21695056}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TICAM1 Gene COMPARTMENTS Subcellular localization image for TICAM1 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 3
vacuole 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagosome IEA --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0097342 ripoptosome IDA 21737330
genes like me logo Genes that share ontologies with TICAM1: view

Pathways & Interactions for TICAM1 Gene

genes like me logo Genes that share pathways with TICAM1: view

SIGNOR curated interactions for TICAM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IEA --
GO:0002756 MyD88-independent toll-like receptor signaling pathway IEA,TAS --
GO:0006954 inflammatory response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS --
GO:0030890 positive regulation of B cell proliferation IEA --
genes like me logo Genes that share ontologies with TICAM1: view

Drugs & Compounds for TICAM1 Gene

(1) Drugs for TICAM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TICAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TICAM1: view

Transcripts for TICAM1 Gene

mRNA/cDNA for TICAM1 Gene

Unigene Clusters for TICAM1 Gene

Toll-like receptor adaptor molecule 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TICAM1 Gene

No ASD Table

Relevant External Links for TICAM1 Gene

GeneLoc Exon Structure for
TICAM1
ECgene alternative splicing isoforms for
TICAM1

Expression for TICAM1 Gene

mRNA expression in normal human tissues for TICAM1 Gene

mRNA differential expression in normal tissues according to GTEx for TICAM1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TICAM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TICAM1 Gene:

TICAM1

SOURCE GeneReport for Unigene cluster for TICAM1 Gene:

Hs.29344

mRNA Expression by UniProt/SwissProt for TICAM1 Gene:

Q8IUC6-TCAM1_HUMAN
Tissue specificity: Ubiquitously expressed but with higher levels in liver.
genes like me logo Genes that share expression patterns with TICAM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for TICAM1 Gene

Orthologs for TICAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TICAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TICAM1 34
  • 77.27 (n)
  • 71.9 (a)
TICAM1 35
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TICAM1 34
  • 76.97 (n)
  • 71.24 (a)
TICAM1 35
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ticam1 34
  • 66.47 (n)
  • 57.6 (a)
Ticam1 16
Ticam1 35
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TICAM1 34
  • 98.31 (n)
  • 98.31 (a)
TICAM1 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ticam1 34
  • 66.37 (n)
  • 57.14 (a)
oppossum
(Monodelphis domestica)
Mammalia TICAM1 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TICAM1 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves TICAM1 35
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TICAM1 35
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ticam1 35
  • 25 (a)
OneToMany
ticam1 35
  • 25 (a)
OneToMany
Species where no ortholog for TICAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TICAM1 Gene

ENSEMBL:
Gene Tree for TICAM1 (if available)
TreeFam:
Gene Tree for TICAM1 (if available)

Paralogs for TICAM1 Gene

No data available for Paralogs for TICAM1 Gene

Variants for TICAM1 Gene

Sequence variations from dbSNP and Humsavar for TICAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_038789 A breast cancer sample
rs11466719 - 4,818,155(-) TGGCC(C/T)GCCAG reference, missense
rs11466721 - 4,817,555(-) CTGGG(C/G)TTCCC reference, missense
rs11466724 - 4,816,382(+) CTACG(A/C/G/T)CCTCA reference, missense
rs146550489 Herpes simplex encephalitis 4 (HSE4) 4,817,821(+) AGTCC(A/G)AAACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TICAM1 Gene

Variant ID Type Subtype PubMed ID
nsv1062709 CNV loss 25217958
nsv470117 CNV loss 18288195

Variation tolerance for TICAM1 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TICAM1 Gene

Human Gene Mutation Database (HGMD)
TICAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TICAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TICAM1 Gene

Disorders for TICAM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TICAM1 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex encephalitic 6
  • herpes simplex encephalitis 4
herpes simplex encephalitis
  • herpetic encephalitis
herpes simplex
  • herpesvirus hominis disease
encephalitis
pertussis
  • bordetella infection
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TCAM1_HUMAN
  • Herpes simplex encephalitis 4 (HSE4) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269 PubMed:22105173}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TICAM1

Genetic Association Database (GAD)
TICAM1
Human Genome Epidemiology (HuGE) Navigator
TICAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TICAM1
genes like me logo Genes that share disorders with TICAM1: view

No data available for Genatlas for TICAM1 Gene

Publications for TICAM1 Gene

  1. A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. (PMID: 12471095) Yamamoto M. … Akira S. (J. Immunol. 2002) 2 3 4 22 65
  2. The human adaptor SARM negatively regulates adaptor protein TRIF- dependent Toll-like receptor signaling. (PMID: 16964262) Carty M. … Bowie A.G. (Nat. Immunol. 2006) 3 4 22 65
  3. NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PMID: 15611223) Sasai M. … Seya T. (J. Immunol. 2005) 3 4 22 65
  4. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PMID: 14739303) Han K.J. … Shu H.-B. (J. Biol. Chem. 2004) 3 4 22 65
  5. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN- beta. (PMID: 14982987) Jiang Z. … Li X. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 65

Products for TICAM1 Gene

Sources for TICAM1 Gene

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