Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIAM2 Gene

Aliases for TIAM2 Gene

  • T-Cell Lymphoma Invasion And Metastasis 2 2 3 5
  • SIF And TIAM1-Like Exchange Factor 3 4
  • TIAM-2 3 4
  • STEF 3 4
  • T-Lymphoma Invasion And Metastasis-Inducing Protein 2 3
  • KIAA2016 4

External Ids for TIAM2 Gene

Previous GeneCards Identifiers for TIAM2 Gene

  • GC06P155030
  • GC06P155364
  • GC06P155459
  • GC06P155479
  • GC06P155520
  • GC06U900794
  • GC06P152973
  • GC06P155153

Summaries for TIAM2 Gene

Entrez Gene Summary for TIAM2 Gene

  • This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAM2 Gene

TIAM2 (T-Cell Lymphoma Invasion And Metastasis 2) is a Protein Coding gene. Diseases associated with TIAM2 include Lymphoma. Among its related pathways are Signaling by GPCR and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TIAM1.

UniProtKB/Swiss-Prot for TIAM2 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAM2 Gene

Genomics for TIAM2 Gene

Regulatory Elements for TIAM2 Gene

Enhancers for TIAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F155223 1.4 FANTOM5 Ensembl ENCODE 23.7 +391.7 391677 1.7 ELF3 PKNOX1 JUN TEAD3 GATA3 CBX5 EED ETV6 FOS FOSL2 TIAM2 SCAF8 ENSG00000235381 LOC100421330
GH06F155245 1.1 Ensembl ENCODE 11.3 +414.7 414650 3.6 PAF1 CTCF ZNF654 TEAD4 TRIM22 RAD21 ZNF121 RAD51 POLR2A SMC3 ENSG00000235381 TIAM2 LOC100421330
GH06F155252 0.9 ENCODE 11.3 +420.9 420850 1.7 ZFHX2 JUND SAP130 POLR2A NFE2 HOMEZ EGR2 ENSG00000235381 TIAM2 LOC100421330
GH06F155264 0.7 ENCODE 11.3 +432.5 432481 0.4 PKNOX1 REST MAFK ENSG00000235381 TIAM2 CLDN20 TFB1M
GH06F155272 0.8 Ensembl ENCODE 11.3 +440.9 440877 2.9 CTCF JUN JUND ZNF316 SMARCA4 IKZF1 KDM1A NFE2 MAFK ENSG00000235381 TIAM2 ENSG00000238963 TFB1M CLDN20
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TIAM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIAM2 Gene

Chromosome:
6
Start:
154,832,697 bp from pter
End:
155,257,723 bp from pter
Size:
425,027 bases
Orientation:
Plus strand

Genomic View for TIAM2 Gene

Genes around TIAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAM2 Gene

Proteins for TIAM2 Gene

  • Protein details for TIAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF5-TIAM2_HUMAN
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 2
    Protein Accession:
    Q8IVF5
    Secondary Accessions:
    • B2RP56
    • C9JZV2
    • Q6NXN9
    • Q6ZUP9
    • Q9UFG6
    • Q9UKV9
    • Q9UKW0

    Protein attributes for TIAM2 Gene

    Size:
    1701 amino acids
    Molecular mass:
    190103 Da
    Quaternary structure:
    • Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2 (By similarity).
    SequenceCaution:
    • Sequence=AAF05900.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC23112.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86170.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TIAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAM2 Gene

Post-translational modifications for TIAM2 Gene

  • Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIAM2 Gene

Domains & Families for TIAM2 Gene

Suggested Antigen Peptide Sequences for TIAM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVF5

UniProtKB/Swiss-Prot:

TIAM2_HUMAN :
  • The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity).
  • Belongs to the TIAM family.
Domain:
  • The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity).
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 2 PH domains.
  • Contains 1 RBD (Ras-binding) domain.
Family:
  • Belongs to the TIAM family.
genes like me logo Genes that share domains with TIAM2: view

Function for TIAM2 Gene

Molecular function for TIAM2 Gene

GENATLAS Biochemistry:
murine T lymphoma invasion and metastasis inducing gene 2 (Tiam2) homolog,expressed in cerebrum,cerebellum and testis,involved in neural cell development with two alternatively spliced isoforms,long and short,lacking the EX and PDZ motifs
UniProtKB/Swiss-Prot Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

Gene Ontology (GO) - Molecular Function for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor IEA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with TIAM2: view
genes like me logo Genes that share phenotypes with TIAM2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TIAM2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIAM2 Gene

Localization for TIAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM2 Gene

Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIAM2 Gene COMPARTMENTS Subcellular localization image for TIAM2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
golgi apparatus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0030027 lamellipodium IEA --
genes like me logo Genes that share ontologies with TIAM2: view

Pathways & Interactions for TIAM2 Gene

genes like me logo Genes that share pathways with TIAM2: view

Gene Ontology (GO) - Biological Process for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with TIAM2: view

No data available for SIGNOR curated interactions for TIAM2 Gene

Drugs & Compounds for TIAM2 Gene

(3) Drugs for TIAM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with TIAM2: view

Transcripts for TIAM2 Gene

mRNA/cDNA for TIAM2 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIAM2 Gene

T-cell lymphoma invasion and metastasis 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TIAM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TIAM2 Gene

GeneLoc Exon Structure for
TIAM2
ECgene alternative splicing isoforms for
TIAM2

Expression for TIAM2 Gene

mRNA expression in normal human tissues for TIAM2 Gene

Protein differential expression in normal tissues from HIPED for TIAM2 Gene

This gene is overexpressed in Frontal cortex (55.9) and Heart (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIAM2 Gene



Protein tissue co-expression partners for TIAM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIAM2 Gene:

TIAM2

SOURCE GeneReport for Unigene cluster for TIAM2 Gene:

Hs.586279

mRNA Expression by UniProt/SwissProt for TIAM2 Gene:

Q8IVF5-TIAM2_HUMAN
Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
genes like me logo Genes that share expression patterns with TIAM2: view

Primer Products

No data available for mRNA differential expression in normal tissues for TIAM2 Gene

Orthologs for TIAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAM2 34 35
  • 99.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TIAM2 34 35
  • 85.39 (n)
rat
(Rattus norvegicus)
Mammalia LOC100362710 34
  • 84.1 (n)
dog
(Canis familiaris)
Mammalia TIAM2 34 35
  • 83.99 (n)
mouse
(Mus musculus)
Mammalia Tiam2 34 16 35
  • 83.76 (n)
oppossum
(Monodelphis domestica)
Mammalia TIAM2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIAM2 34
  • 74 (n)
lizard
(Anolis carolinensis)
Reptilia TIAM2 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tiam2 34
  • 58.19 (n)
TIAM2 (1 of 2) 35
  • 52 (a)
OneToMany
tiam2a 35
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sif 36 35
  • 48 (a)
Species where no ortholog for TIAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAM2 Gene

ENSEMBL:
Gene Tree for TIAM2 (if available)
TreeFam:
Gene Tree for TIAM2 (if available)

Paralogs for TIAM2 Gene

genes like me logo Genes that share paralogs with TIAM2: view

Variants for TIAM2 Gene

Sequence variations from dbSNP and Humsavar for TIAM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10081066 -- 155,198,063(+) CCTTT(C/T)ATGCT intron-variant
rs10214877 -- 155,163,848(+) GCATT(C/T)TCCAA intron-variant
rs10223883 -- 155,099,557(+) ACAAA(C/T)GTGAT intron-variant
rs1032140 -- 155,164,401(+) CCTCT(A/G)TTTTT intron-variant
rs1032141 -- 155,164,420(+) ATCCA(A/G)CAATG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TIAM2 Gene

Variant ID Type Subtype PubMed ID
esv3328575 CNV duplication 20981092
esv3400314 CNV insertion 20981092
esv5639 OTHER inversion 19470904
esv9372 CNV gain 19470904
nsv1025003 CNV gain 25217958
nsv525690 CNV loss 19592680
nsv526576 CNV loss 19592680
nsv5552 CNV deletion 18451855

Variation tolerance for TIAM2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.12; 96.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAM2 Gene

Disorders for TIAM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TIAM2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search TIAM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIAM2

Genetic Association Database (GAD)
TIAM2
Human Genome Epidemiology (HuGE) Navigator
TIAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIAM2
genes like me logo Genes that share disorders with TIAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIAM2 Gene

Publications for TIAM2 Gene

  1. Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. (PMID: 10512681) Chiu C.-Y. … Duhl D.M. (Genomics 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma. (PMID: 26763486) Yen W.H. … Sun H.S. (Cancer Med 2016) 3 64
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64
  5. TIAM2 Enhances Non-small Cell Lung Cancer Cell Invasion and Motility. (PMID: 24377522) Zhao Z.Y. … Cheng L.Y. (Asian Pac. J. Cancer Prev. 2013) 3 64

Products for TIAM2 Gene

Sources for TIAM2 Gene

Content
Loading form....