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Aliases for TIAM2 Gene

Aliases for TIAM2 Gene

  • T-Cell Lymphoma Invasion And Metastasis 2 2 3
  • SIF And TIAM1-Like Exchange Factor 3 4
  • TIAM-2 3 4
  • STEF 3 4
  • T-Lymphoma Invasion And Metastasis-Inducing Protein 2 3
  • KIAA2016 4

External Ids for TIAM2 Gene

Previous GeneCards Identifiers for TIAM2 Gene

  • GC06P155030
  • GC06P155364
  • GC06P155459
  • GC06P155479
  • GC06P155520
  • GC06U900794
  • GC06P152973
  • GC06P155153

Summaries for TIAM2 Gene

Entrez Gene Summary for TIAM2 Gene

  • This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAM2 Gene

TIAM2 (T-Cell Lymphoma Invasion And Metastasis 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for TIAM2 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAM2 Gene

Genomics for TIAM2 Gene

Regulatory Elements for TIAM2 Gene

Genomic Location for TIAM2 Gene

Start:
154,832,697 bp from pter
End:
155,257,723 bp from pter
Size:
425,027 bases
Orientation:
Plus strand

Genomic View for TIAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAM2 Gene

Proteins for TIAM2 Gene

  • Protein details for TIAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF5-TIAM2_HUMAN
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 2
    Protein Accession:
    Q8IVF5
    Secondary Accessions:
    • B2RP56
    • C9JZV2
    • Q6NXN9
    • Q6ZUP9
    • Q9UFG6
    • Q9UKV9
    • Q9UKW0

    Protein attributes for TIAM2 Gene

    Size:
    1701 amino acids
    Molecular mass:
    190103 Da
    Quaternary structure:
    • Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2 (By similarity).
    SequenceCaution:
    • Sequence=AAF05900.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC23112.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86170.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TIAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAM2 Gene

Proteomics data for TIAM2 Gene at MOPED

Post-translational modifications for TIAM2 Gene

  • Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIAM2 Gene

Domains for TIAM2 Gene

Gene Families for TIAM2 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for TIAM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVF5

UniProtKB/Swiss-Prot:

TIAM2_HUMAN :
  • Q8IVF5
Domain:
  • The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity).
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 2 PH domains.
  • Contains 1 RBD (Ras-binding) domain.
Family:
  • Belongs to the TIAM family.
genes like me logo Genes that share domains with TIAM2: view

Function for TIAM2 Gene

Molecular function for TIAM2 Gene

GENATLAS Biochemistry: murine T lymphoma invasion and metastasis inducing gene 2 (Tiam2) homolog,expressed in cerebrum,cerebellum and testis,involved in neural cell development with two alternatively spliced isoforms,long and short,lacking the EX and PDZ motifs
UniProtKB/Swiss-Prot Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

Gene Ontology (GO) - Molecular Function for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS 10512681
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TIAM2: view

Phenotypes for TIAM2 Gene

genes like me logo Genes that share phenotypes with TIAM2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TIAM2 Gene

Localization for TIAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM2 Gene

Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIAM2 Gene COMPARTMENTS Subcellular localization image for TIAM2 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0030027 lamellipodium IEA --
GO:0030175 filopodium IEA --
genes like me logo Genes that share ontologies with TIAM2: view

Pathways for TIAM2 Gene

genes like me logo Genes that share pathways with TIAM2: view

Gene Ontology (GO) - Biological Process for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0035556 intracellular signal transduction --
GO:0043065 positive regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with TIAM2: view

Compounds for TIAM2 Gene

(3) HMDB Compounds for TIAM2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with TIAM2: view

Transcripts for TIAM2 Gene

mRNA/cDNA for TIAM2 Gene

(9) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIAM2 Gene

T-cell lymphoma invasion and metastasis 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIAM2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TIAM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TIAM2 Gene

GeneLoc Exon Structure for
TIAM2
ECgene alternative splicing isoforms for
TIAM2

Expression for TIAM2 Gene

mRNA expression in normal human tissues for TIAM2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TIAM2 Gene

SOURCE GeneReport for Unigene cluster for TIAM2 Gene Hs.586279

mRNA Expression by UniProt/SwissProt for TIAM2 Gene

Q8IVF5-TIAM2_HUMAN
Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
genes like me logo Genes that share expressions with TIAM2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TIAM2 Gene

Orthologs for TIAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAM2 35
  • 99.37 (n)
  • 99.29 (a)
TIAM2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TIAM2 35
  • 85.39 (n)
  • 88.19 (a)
TIAM2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIAM2 35
  • 83.99 (n)
  • 85.51 (a)
TIAM2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tiam2 35
  • 83.76 (n)
  • 84.98 (a)
Tiam2 16
Tiam2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIAM2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100362710 35
  • 84.1 (n)
  • 85.96 (a)
chicken
(Gallus gallus)
Aves TIAM2 35
  • 74 (n)
  • 78.22 (a)
lizard
(Anolis carolinensis)
Reptilia TIAM2 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tiam2 35
  • 58.19 (n)
  • 55.94 (a)
TIAM2 (1 of 2) 36
  • 52 (a)
OneToMany
tiam2a 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sif 36
  • 20 (a)
OneToMany
sif 37
  • 48 (a)
Species with no ortholog for TIAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAM2 Gene

ENSEMBL:
Gene Tree for TIAM2 (if available)
TreeFam:
Gene Tree for TIAM2 (if available)

Paralogs for TIAM2 Gene

Selected SIMAP similar genes for TIAM2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with TIAM2: view

Variants for TIAM2 Gene

Sequence variations from dbSNP and Humsavar for TIAM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs745535 -- 155,219,629(-) AATTT(A/T)TTAAA intron-variant
rs745536 -- 155,219,628(-) ATTTT(A/T)TAAAA intron-variant
rs745537 -- 155,220,012(-) TTCTT(A/C)CCACT intron-variant
rs751975 -- 155,208,893(-) TTGCC(A/G)AGTGT intron-variant
rs751976 -- 155,209,226(-) CTCTC(A/G)CGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIAM2 Gene

Variant ID Type Subtype PubMed ID
nsv886789 CNV Gain 21882294
esv9372 CNV Gain 19470904
esv271450 CNV Insertion 20981092
esv274656 CNV Insertion 20981092
nsv5552 CNV Loss 18451855
nsv886790 CNV Loss 21882294
esv5639 OTHER Inversion 19470904
nsv525690 CNV Loss 19592680
nsv526576 CNV Loss 19592680

Relevant External Links for TIAM2 Gene

HapMap Linkage Disequilibrium report
TIAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAM2 Gene

Disorders for TIAM2 Gene

Relevant External Links for TIAM2

Genetic Association Database (GAD)
TIAM2
Human Genome Epidemiology (HuGE) Navigator
TIAM2
genes like me logo Genes that share disorders with TIAM2: view

No data available for UniProtKB/Swiss-Prot for TIAM2 Gene

Publications for TIAM2 Gene

  1. Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. (PMID: 10512681) Chiu C.-Y. … Duhl D.M. (Genomics 1999) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer. (PMID: 21469146) Chen J.S. … Sun H.S. (Int. J. Cancer 2012) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. TIAM2 Enhances Non-small Cell Lung Cancer Cell Invasion and Motility. (PMID: 24377522) Zhao Z.Y. … Cheng L.Y. (Asian Pac. J. Cancer Prev. 2013) 3

Products for TIAM2 Gene

Sources for TIAM2 Gene

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