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TIAM2 Gene

protein-coding   GIFtS: 59
GCID: GC06P155153

T-Cell Lymphoma Invasion And Metastasis 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Cell Lymphoma Invasion And Metastasis 21 2
STEF2 3
TIAM-22 3
SIF And TIAM1-Like Exchange Factor2 3
T-Lymphoma Invasion And Metastasis-Inducing Protein 22
KIAA20163

External Ids:    HGNC: 118061   Entrez Gene: 262302   Ensembl: ENSG000001464267   OMIM: 6047095   UniProtKB: Q8IVF53   

Export aliases for TIAM2 gene to outside databases

Previous GC identifers: GC06P155030 GC06P155364 GC06P155459 GC06P155479 GC06P155520 GC06U900794 GC06P152973


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIAM2 Gene:
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates
ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine
diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a
role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been
described. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIAM2 Gene:
TIAM2 (T-cell lymphoma invasion and metastasis 2) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF6.

UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5
Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal
activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of
RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to
neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal
neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling
accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates
specifically RAC1, but not CDC42 and RHOA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIAM2 gene promoter:
         AP-1   ATF-2   Nkx3-1 v1   CUTL1   aMEF-2   c-Jun   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIAM2 promoter sequence
   Search Chromatin IP Primers for TIAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25

TIAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIAM2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P155153:  view genomic region     (about GC identifiers)

Start:
155,153,831 bp from pter      End:
155,578,857 bp from pter
Size:
425,027 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5 (See protein sequence)
Recommended Name: T-lymphoma invasion and metastasis-inducing protein 2  
Size: 1701 amino acids; 190103 Da
Subunit: Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2 (By similarity)
Sequence caution: Sequence=AAF05900.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC23112.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC86170.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RP56 C9JZV2 Q6NXN9 Q6ZUP9 Q9UFG6 Q9UKV9 Q9UKW0
Alternative splicing: 5 isoforms:  Q8IVF5-1   Q8IVF5-2   Q8IVF5-3   Q8IVF5-4   Q8IVF5-5   

Explore the universe of human proteins at neXtProt for TIAM2: NX_Q8IVF5

Explore proteomics data for TIAM2 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by
    Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE
    and reduces its ability to promote neurite growth (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010927.1  NP_036586.2  

    ENSEMBL proteins: 
     ENSP00000437188   ENSP00000444040   ENSP00000437435   ENSP00000443546   ENSP00000434901  
     ENSP00000442989   ENSP00000353528   ENSP00000433348   ENSP00000407183   ENSP00000435335  
     ENSP00000444897   ENSP00000275246   ENSP00000431269   ENSP00000407746   ENSP00000327315  
     ENSP00000356142  
    Reactome Protein details: Q8IVF5

    TIAM2 Human Recombinant Protein Products:

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    Novus Biologicals TIAM2 Proteins
    Novus Biologicals TIAM2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIAM2

     
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    TIAM2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TIAM2 Antibodies
    Abcam antibodies for TIAM2
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    LSBio Antibodies in human, mouse, rat for TIAM2

    TIAM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TIAM2
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    Search eBioscience for ELISAs for TIAM2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 6):
     IPR001331 GDS_CDC24_CS
     IPR001478 PDZ
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR003116 Raf-like_ras-bd

    Graphical View of Domain Structure for InterPro Entry Q8IVF5

    ProtoNet protein and cluster: Q8IVF5

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5
    Domain: The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for
    membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in
    the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary
    to induce neurite-like structure (By similarity)
    Similarity: Belongs to the TIAM family
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 2 PH domains
    Similarity: Contains 1 RBD (Ras-binding) domain


    Find genes that share domains with TIAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIAM2_HUMAN, Q8IVF5
    Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal
    activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of
    RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to
    neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal
    neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling
    accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates
    specifically RAC1, but not CDC42 and RHOA

         Genatlas biochemistry entry for TIAM2:
    murine T lymphoma invasion and metastasis inducing gene 2 (Tiam2) homolog,expressed in cerebrum,cerebellum and
    testis,involved in neural cell development with two alternatively spliced isoforms,long and short,lacking the EX
    and PDZ motifs

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005085guanyl-nucleotide exchange factor activity TAS10512681
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TIAM2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TIAM2:
     Decreased Tat-dependent transc  Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIAM2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIAM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIAM2

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TIAM2:
    hsa-miR-365 hsa-miR-101 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidTIAM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIAM2
    Predesigned siRNA for gene silencing in human, mouse, rat TIAM2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TIAM2

    Clone
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    OriGene clones in human, mouse for TIAM2 (see all 11)
    OriGene ORF clones in mouse, rat for TIAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIAM2 (NM_012454)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TIAM2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIAM2_HUMAN, Q8IVF5: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection,
    filopodium (By similarity). Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--
    GO:0030027lamellipodium IEA--
    GO:0030175filopodium IEA--

    Find genes that share ontologies with TIAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TIAM2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    4Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with TIAM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TIAM2
        Regulation of RAC1 activity

    4 Reactome Pathways for TIAM2
        G alpha (12/13) signalling events
    PPARA activates gene expression
    NRAGE signals death through JNK
    Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TIAM2
    Interactions:

        GeneGlobe Interaction Network for TIAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIAM2 (Q8IVF52, 3 ENSP000003273154) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248768 I2D: score=2 
    DNM2P505702, 3MINT-8254487 I2D: score=2 
    H2AFXP161042, 3MINT-8257988 I2D: score=2 
    SH3GL2Q999622, 3MINT-8270594 I2D: score=2 
    TK1P041832, 3MINT-8274192 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043065positive regulation of apoptotic process TAS--
    GO:0043547positive regulation of GTPase activity ----

    Find genes that share ontologies with TIAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIAM2

    3 HMDB Compounds for TIAM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TIAM2 gene (2 alternative transcripts): 
    NM_001010927.2  NM_012454.3  

    Unigene Cluster for TIAM2:

    T-cell lymphoma invasion and metastasis 2
    Hs.586279  [show with all ESTs]
    Unigene Representative Sequence: NM_012454
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000461783(uc003qqb.3) ENST00000535064 ENST00000460692 ENST00000449545(uc003qqc.1)
    ENST00000545347 ENST00000538270 ENST00000535231 ENST00000528535 ENST00000431620
    ENST00000535583 ENST00000360366 ENST00000529824 ENST00000456877 ENST00000528391(uc011efl.1)
    ENST00000543712 ENST00000539296 ENST00000275246 ENST00000546145
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTIAM2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIAM2 (NM_012454)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAM2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIAM2
      QuantiTect SYBR Green Assays in human, mouse, rat TIAM2
      QuantiFast Probe-based Assays in human, mouse, rat TIAM2

    Additional mRNA sequence: 

    AF195656.1 AK123859.1 AK125459.1 AK299723.1 AK302860.1 AL122086.1 BC022469.1 BC066979.1 
    BC137275.1 

    12 DOTS entries:

    DT.100746277  DT.121369086  DT.101976318  DT.99928812  DT.92427137  DT.101976317  DT.95362817  DT.121368902 
    DT.100736873  DT.121369042  DT.101969141  DT.91811204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TIAM2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^
    SP1:                                                  -     -                 -                                               -                             -   
    SP2:                                                  -     -                 -                                               -                             -   
    SP3:                                                                                                                                                        -   
    SP4:                                                                          -           -     -     -     -     -     -     -     -     -     -           -   
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
    SP1:                                                  -                                 
    SP2:                          -                                                         
    SP3:                          -                       -                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TIAM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAACTAT
    TIAM2 Expression
    About this image


    TIAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TIAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.586279

    UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5
    Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TIAM2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tiam21 , 5 T cell lymphoma invasion and metastasis 21, 5 83.76(n)1
    84.98(a)1
      17 (1.99 cM)5
    240011  NM_011878.21  NP_036008.21 
     33265735 
    chicken
    (Gallus gallus)
    Aves TIAM21 T-cell lymphoma invasion and metastasis 2 74(n)
    78.22(a)
      421648  NM_001267535.1  NP_001254464.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIAM26
    T-cell lymphoma invasion and metastasis 2
    71(a)
    1 ↔ 1
    1(214616969-214763610)
    zebrafish
    (Danio rerio)
    Actinopterygii tiam21 T-cell lymphoma invasion and metastasis 2 58.19(n)
    55.94(a)
      100334442  XM_002665252.3  XP_002665298.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta sif3 actin cytoskeleton organization and
    biogenesis more
    48(a)     --


    ENSEMBL Gene Tree for TIAM2 (if available)
    TreeFam Gene Tree for TIAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIAM2 gene
    ARHGEF62  PLEKHG22  PLEKHG32  PREX22  ENSG000002731672  ARHGEF72  TIAM12  SPATA132  
    ARHGEF92  ARHGEF42  PLEKHG12  PREX12  
    2 SIMAP similar genes for TIAM2 using alignment to 10 protein entries:     TIAM2_HUMAN (see all proteins):
    TIAM1    PREX2

    Find genes that share paralogs with TIAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIAM2 (see all 3788)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77389461,2
    C--155409434(+) ggtctC/Tgaact 1 -- us2k10--------
    rs1862725791,2
    --155409435(+) GTCTCA/GAACTC 1 -- us2k10--------
    rs1915688801,2
    --155409516(+) GGCCCC/TGGTAT 1 -- us2k10--------
    rs1468142411,2
    --155409822(+) CCTTGA/CTCTAA 1 -- us2k10--------
    rs1128010531,2
    C,F--155409872(+) GCCCAG/CGATGG 1 -- us2k13Minor allele frequency- C:0.08CSA WA 121
    rs1406322771,2
    --155409946(+) ATTTTC/TTTTAA 1 -- us2k10--------
    rs1128173121,2
    C,F--155410005(+) GACAGC/TTTCTC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1821770061,2
    --155410007(+) CAGTTC/TCTCTT 1 -- us2k10--------
    rs170859531,2
    C,F,H--155410073(+) TCTTTA/GTCAAG 1 -- us2k111Minor allele frequency- G:0.05NA NS EA CSA WA 682
    rs1452096671,2
    --155410112(+) TTATTG/TCCATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TIAM2 (155153831 - 155403831 bp, first 250kb of TIAM2)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TIAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271450CNV Insertion20981092
    esv274656CNV Insertion20981092
    nsv5552CNV Loss18451855
    nsv526576CNV Loss19592680
    nsv525690CNV Loss19592680
    nsv886790CNV Loss21882294
    esv9372CNV Gain19470904
    nsv886789CNV Gain21882294
    esv5639OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604709    OMIM disorders: --


    Find genes that share disorders with TIAM2           About GenesLikeMe

    Genetic Association Database (GAD): TIAM2
    Human Genome Epidemiology (HuGE) Navigator: TIAM2 (2 documents)

    Export disorders for TIAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIAM2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TIAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. (PubMed id 10512681)1, 2, 3 Chiu C.-Y.... Duhl D.M. (Genomics 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer. (PubMed id 21469146)1 Chen J.S....Sun H.S. (Int. J. Cancer 2012)
    4. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    6. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    7. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    8. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (Mol. Psychiatry 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. (PubMed id 15723051)1 Nishimura T....Kaibuchi K. (Nat. Cell Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26230 HGNC: 11806 Ensembl:ENSG00000146426 euGenes: HUgn26230 ECgene: TIAM2
    H-InvDB: TIAM2

    (According to HUGE)
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    HUGE: KIAA2016

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIAM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIAM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIAM2 gene:
    Search GeneIP for patents involving TIAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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