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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIAM2 Gene

protein-coding GIFtS: 60
GCID: GC06P155153

T-cell lymphoma invasion and metastasis 2

Explore 3 diseases affiliated with
TIAM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T-Cell Lymphoma Invasion And Metastasis 2¹ ²
STEF¹ ² ³
TIAM-2² ³
SIF And TIAM1-Like Exchange Factor² ³
T-Lymphoma Invasion And Metastasis-Inducing Protein 2²
KIAA2016³

External Ids:	HGNC: 11806¹	Entrez Gene: 26230²	Ensembl: ENSG00000146426⁷	OMIM: 604709⁵	UniProtKB: Q8IVF5³

Export aliases for TIAM2 gene to outside databases

Previous GC identifers: GC06P155030 GC06P155364 GC06P155459 GC06P155479 GC06P155520 GC06U900794 GC06P152973

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIAM2:

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates

ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine

diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role

in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5

Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities.

Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and

activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in

lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of

neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin

filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIAM2 gene promoter:
AP-1 ATF-2 Nkx3-1 v1 CUTL1 aMEF-2 c-Jun Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TIAM2 promoter sequence

Search SABiosciences Chromatin IP Primers for TIAM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIAM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q25

TIAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIAM2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P155153: view genomic region (about GC identifiers)

Start:	155,153,831 bp from pter	End:	155,578,857 bp from pter
Size:	425,027 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5 (See protein sequence)

Recommended Name: T-lymphoma invasion and metastasis-inducing protein 2

Size: 1701 amino acids; 190103 Da

Subunit: Interacts with MAP1A, MAP1B, PARP1 and YWHAE (By similarity)

Subcellular location: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection,

filopodium (By similarity). Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites (By

similarity)

Sequence caution: Sequence=AAF05900.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAC23112.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC86170.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B2RP56 C9JZV2 Q6NXN9 Q6ZUP9 Q9UFG6 Q9UKV9 Q9UKW0

Alternative splicing: 5 isoforms: Q8IVF5-1 Q8IVF5-2 Q8IVF5-3 Q8IVF5-4 Q8IVF5-5

Explore the universe of human proteins at neXtProt for TIAM2: NX_Q8IVF5

Post-translational modifications:

Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by

Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and

reduces its ability to promote neurite growth (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IVF5

TIAM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001010927.1 NP_036586.2

ENSEMBL proteins:

ENSP00000437188 ENSP00000444040 ENSP00000437435 ENSP00000443546 ENSP00000434901

ENSP00000442989 ENSP00000353528 ENSP00000433348 ENSP00000407183 ENSP00000435335

ENSP00000444897 ENSP00000275246 ENSP00000431269 ENSP00000407746 ENSP00000327315

ENSP00000356142

Reactome Protein details: Q8IVF5
Human Recombinant Protein Products:

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	Novus Biologicals TIAM2 Proteins Novus Biologicals TIAM2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TIAM2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	IEA	--

TIAM2 for ontologies About GeneDecksing

TIAM2 Antibody Products:

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	Novus Biologicals TIAM2 Antibodies
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	Uscn Antibodies for TIAM2
	Search ThermoFisher Antibodies for TIAM2

Assay Products for TIAM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for TIAM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TIAM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIAM2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001331 GDS_CDC24_CS

IPR001478 PDZ

IPR000219 DH-domain

IPR001849 Pleckstrin_homology

IPR003116 Raf-like_ras-bd

Graphical View of Domain Structure for InterPro Entry Q8IVF5

ProtoNet protein and cluster: Q8IVF5

3 Blocks protein families:

IPB000219 DH domain

IPB001849 Pleckstrin-like

IPB011072 Protein kinase PKN/PRK1

UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5

Domain: The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for

membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the

enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce

neurite-like structure (By similarity)

Similarity: Belongs to the TIAM family

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 2 PH domains

Similarity: Contains 1 RBD (Ras-binding) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5

Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities.

Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and

activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in

lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of

neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin

filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA

Genatlas biochemistry entry for TIAM2:

murine T lymphoma invasion and metastasis inducing gene 2 (Tiam2) homolog,expressed in cerebrum,cerebellum and

testis,involved in neural cell development with two alternatively spliced isoforms,long and short,lacking the EX and

PDZ motifs

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TIAM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIAM2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate TIAM2:
		hsa-miR-365 hsa-miR-101 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: TIAM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIAM2 (see all 4) OriGene shRNA RFP: TIAM2 OriGene siRNA: TIAM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIAM2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TIAM2

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TIAM2
		Search LifeMap BioReagents cell lines for TIAM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAM2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005085	guanyl-nucleotide exchange factor activity	TAS	10512681
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005096	GTPase activator activity	IEA	--
GO:0005543	phospholipid binding	IEA	--

TIAM2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TIAM2:

Decreased Tat-dependent transc

Decreased Wnt reporter activit

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Cell death signalling via NRAGE, NRIF and NADE	1.00	G alpha (12/13) signalling events	0.39
NRAGE signals death through JNK	0.74	Rho GTPase cycle	0.25
p75 NTR receptor-mediated signalling	0.73	Signaling by Rho GTPases	0.25

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Expression of TIAM2

Expression of TIAM2

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for TIAM2

Regulation of RAC1 activity

5/16 Reactome Pathways for TIAM2 (see all 16)

	G alpha (12/13) signalling events
	Cell death signalling via NRAGE, NRIF and NADE
	Metabolism
	p75 NTR receptor-mediated signalling
	Fatty acid, triacylglycerol, and ketone body metabolism

2 Kegg Pathways (Kegg details for TIAM2):

	Chemokine signaling pathway
	Regulation of actin cytoskeleton

TIAM2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TIAM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/33 Interacting proteins for TIAM2 (Q8IVF5^{2, 3} ENSP00000327315⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANXA7	P20073²^,³	MINT-8248768 I2D: score=2
DNM2	P50570²^,³	MINT-8254487 I2D: score=2
H2AFX	P16104²^,³	MINT-8257988 I2D: score=2
SH3GL2	Q99962²^,³	MINT-8270594 I2D: score=2
TK1	P04183²^,³	MINT-8274192 I2D: score=2

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--
GO:0035556	intracellular signal transduction	--	--
GO:0043547	positive regulation of GTPase activity	--	--

TIAM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIAM2

3 HMDB Compounds for TIAM2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about TIAM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TIAM2 gene (2 alternative transcripts):

NM_001010927.2 NM_012454.3

Unigene Cluster for TIAM2:

T-cell lymphoma invasion and metastasis 2

Hs.586279 [show with all ESTs]

Unigene Representative Sequence: NM_012454

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000461783(uc003qqb.3) ENST00000535064 ENST00000460692 ENST00000449545(uc003qqc.1)

ENST00000545347 ENST00000538270 ENST00000535231 ENST00000528535 ENST00000431620

ENST00000535583 ENST00000360366 ENST00000529824 ENST00000456877 ENST00000528391(uc011efl.1)

ENST00000543712 ENST00000539296 ENST00000275246 ENST00000546145

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TIAM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIAM2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate TIAM2:
		hsa-miR-365 hsa-miR-101 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: TIAM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIAM2 (see all 4) OriGene shRNA RFP: TIAM2 OriGene siRNA: TIAM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIAM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIAM2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIAM2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TIAM2 (NM_012454)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIAM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIAM2

Additional cDNA sequence:

AF195656.1 AK123859.1 AK125459.1 AK299723.1 AK302860.1 AL122086.1 BC022469.1 BC066979.1

BC137275.1

12 DOTS entries:

DT.100746277 DT.121369086 DT.101976318 DT.99928812 DT.92427137 DT.101976317 DT.95362817 DT.121368902

DT.100736873 DT.121369042 DT.101969141 DT.91811204

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TIAM2 (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	·	20c	^
SP1:																	-		-						-																-										-
SP2:																	-		-						-																-										-
SP3:																																																			-
SP4:																									-				-		-		-		-		-		-		-		-		-		-				-
SP5:

ExUns:	21a	·	21b	^	22	^	23	^	24	^	25	^	26a	·	26b	^	27a	·	27b	^	28	^	29	^	30a	·	30b
SP1:																	-
SP2:									-
SP3:									-								-
SP4:
SP5:

ECgene alternative splicing isoforms for TIAM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIAM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATAACTAT

About this image

TIAM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Right Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

See TIAM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIAM2

SOURCE GeneReport for Unigene cluster: Hs.586279

UniProtKB/Swiss-Prot: TIAM2_HUMAN, Q8IVF5

Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis

SABiosciences Custom PCR Arrays for TIAM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIAM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TIAM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIAM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIAM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TIAM2 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TIAM2¹	T-cell lymphoma invasion and metastasis 2	74(n) 78.22(a)		421648 XM_419687.3 XP_419687.3
lizard (Anolis carolinensis)	Reptilia	TIAM2⁶	--	71(a)	1 ↔ 1	1(214616969-214726909)
zebrafish (Danio rerio)	Actinopterygii	CU694254.2⁶ CABZ01067977.1⁶	--	53(a) 51(a)	1 ↔ 1 possible ortholog	17(49252170-49373557) 20(4341246-4373078)
fruit fly (Drosophila melanogaster)	Insecta	sif³	actin cytoskeleton organization and biogenesis more	48(a)		--
worm (Caenorhabditis elegans)	Secernentea	cgef-2⁶	Protein CGEF-2	15(a)	possible ortholog	I(4422033-4426177)

ENSEMBL Gene Tree for TIAM2 (if available)
TreeFam Gene Tree for TIAM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TIAM2 gene

ARHGEF6² VAV1² PLEKHG2² PLEKHG3² PREX2² ARHGEF7² TIAM1² SPATA13²

ARHGEF9² VAV3² VAV2² ARHGEF4² PLEKHG1² PREX1²

2 SIMAP similar genes for TIAM2 using alignment to 10 protein entries: TIAM2_HUMAN (see all proteins):

TIAM1 PREX2

TIAM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113082030^1,2	C,	--	153139283(+)	`CCAGGC/TGTGAT`	1	--	ds500¹		1		NA	2
rs111319813^1,2		--	153139661(+)	`ACATAG/ATTGAG`	1	--	ut3¹		1		CSA	2
rs57405392^1,2		--	153140017(+)	`AGAGCA/TGCGGC`	1	--	ut3¹		0	--	--	--	--
rs74849543^1,2		--	153141564(+)	`TTAACC/TCTCAT`	1	--	int¹		1		WA	118
rs7738946^1,2	C,	--	155409434(+)	`ggtctC/Tgaact`	1	--	us2k¹		0	--	--	--	--
rs186272579^1,2		--	155409435(+)	`GTCTCA/GAACTC`	1	--	us2k¹		0	--	--	--	--
rs191568880^1,2		--	155409516(+)	`GGCCCC/TGGTAT`	1	--	us2k¹		0	--	--	--	--
rs146814241^1,2		--	155409822(+)	`CCTTGA/CTCTAA`	1	--	us2k¹		0	--	--	--	--
rs112801053^1,2		--	155409872(+)	`GCCCAG/CGATGG`	1	--	us2k¹		3		CSA WA	121
rs140632277^1,2		--	155409946(+)	`ATTTTC/TTTTAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TIAM2 (155153831 - 155403831 bp, first 250kb of TIAM2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TIAM2
1 Indel: 60634
1 Inversion: 59838

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TIAM2 for disorders           About GeneDecksing

OMIM gene information: 604709    OMIM disorders: --

3 diseases for TIAM2:    About MalaCards

cerebritis schizophrenia neuronitis

Human Genome Epidemiology (HuGE) Navigator: TIAM2 (2 documents)

Export disorders for TIAM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TIAM2 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TIAM2)

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Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. (PubMed id 10512681)^{1, 2, 3} Chiu C.-Y.... Duhl D.M. (1999)
Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer. (PubMed id 21469146)¹ Chen J.S....Sun H.S. (2012)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)¹ Camargo L.M....Brandon N.J. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. (PubMed id 15723051)¹ Nishimura T....Kaibuchi K. (2005)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26230	HGNC: 11806	Ensembl:ENSG00000146426	euGenes: HUgn26230	ECgene: TIAM2	Kegg: 26230
H-InvDB: TIAM2

(According to HUGE)
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HUGE: KIAA2016

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TIAM2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TIAM2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TIAM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TIAM2 gene:
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GeneCards and IP:
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