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Aliases for TIAM1 Gene

Aliases for TIAM1 Gene

  • T-Cell Lymphoma Invasion And Metastasis 1 2 3
  • TIAM-1 3 4
  • Human T-Lymphoma Invasion And Metastasis Inducing TIAM1 Protein 3
  • T-Lymphoma Invasion And Metastasis-Inducing Protein 1 3

External Ids for TIAM1 Gene

Summaries for TIAM1 Gene

GeneCards Summary for TIAM1 Gene

TIAM1 (T-Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include spastic quadriplegia and quadriplegia. Among its related pathways are Signaling by FGFR and Ras signaling pathway. GO annotations related to this gene include phospholipid binding and receptor signaling protein activity. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for TIAM1 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Gene Wiki entry for TIAM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAM1 Gene

Genomics for TIAM1 Gene

Genomic Location for TIAM1 Gene

31,118,416 bp from pter
31,559,977 bp from pter
441,562 bases
Minus strand

Genomic View for TIAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAM1 Gene

Regulatory Elements for TIAM1 Gene

Proteins for TIAM1 Gene

  • Protein details for TIAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 1
    Protein Accession:
    Secondary Accessions:
    • B7ZLR6
    • F5GZ53
    • Q17RT7

    Protein attributes for TIAM1 Gene

    1591 amino acids
    Molecular mass:
    177508 Da
    Quaternary structure:
    • Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for TIAM1 Gene

    Alternative splice isoforms for TIAM1 Gene


neXtProt entry for TIAM1 Gene

Proteomics data for TIAM1 Gene at MOPED

Post-translational modifications for TIAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIAM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TIAM1 Gene

Domains for TIAM1 Gene

Gene Families for TIAM1 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing
  • ARHGEF :Rho guanine nucleotide exchange factors

Suggested Antigen Peptide Sequences for TIAM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.:
    • Q13009
  • Contains 1 DH (DBL-homology) domain.:
    • Q13009
  • Contains 1 PDZ (DHR) domain.:
    • Q13009
  • Contains 2 PH domains.:
    • Q13009
  • Contains 1 RBD (Ras-binding) domain.:
    • Q13009
  • Belongs to the TIAM family.:
    • Q13009
genes like me logo Genes that share domains with TIAM1: view

Function for TIAM1 Gene

Molecular function for TIAM1 Gene

GENATLAS Biochemistry: murine T lymphoma invasion and metastasis inducing gene 1 (Tiam1) homolog,overexpressed in bone marrow of Down syndrome children during the acute phase of AML (M7),involved in neural cell development
UniProtKB/Swiss-Prot Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Gene Ontology (GO) - Molecular Function for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005085 guanyl-nucleotide exchange factor activity EXP --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS 10835422
GO:0005515 protein binding --
GO:0005543 phospholipid binding IEA --
genes like me logo Genes that share ontologies with TIAM1: view
genes like me logo Genes that share phenotypes with TIAM1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIAM1 Gene

Localization for TIAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM1 Gene

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TIAM1 Gene COMPARTMENTS Subcellular localization image for TIAM1 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane --
GO:0005911 cell-cell junction IDA 20332120
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA 20361982
GO:0044291 cell-cell contact zone IDA 20361982
genes like me logo Genes that share ontologies with TIAM1: view

Pathways for TIAM1 Gene

genes like me logo Genes that share pathways with TIAM1: view

Gene Ontology (GO) - Biological Process for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IMP 20361982
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0016477 cell migration IMP 20361982
genes like me logo Genes that share ontologies with TIAM1: view

Compounds for TIAM1 Gene

(1) HMDB Compounds for TIAM1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(11) Novoseek inferred chemical compound relationships for TIAM1 Gene

Compound -log(P) Hits PubMed IDs
gdp 68.6 8
bufalin 68.2 9
gtp 54.7 7
phosphatidylinositol 3-phosphate 53.4 3
phosphoinositide 46.2 5
genes like me logo Genes that share compounds with TIAM1: view

Transcripts for TIAM1 Gene

Unigene Clusters for TIAM1 Gene

T-cell lymphoma invasion and metastasis 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2: - - - - - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33

Relevant External Links for TIAM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIAM1 Gene

mRNA expression in normal human tissues for TIAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIAM1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (14.6) and Brain - Cerebellum (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIAM1 Gene

SOURCE GeneReport for Unigene cluster for TIAM1 Gene Hs.517228

mRNA Expression by UniProt/SwissProt for TIAM1 Gene

Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas
genes like me logo Genes that share expressions with TIAM1: view

Orthologs for TIAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIAM1 35
  • 99.69 (n)
  • 99.81 (a)
TIAM1 36
  • 100 (a)
(Bos Taurus)
Mammalia TIAM1 35
  • 90.49 (n)
  • 95.06 (a)
TIAM1 36
  • 94 (a)
(Canis familiaris)
Mammalia TIAM1 35
  • 91.31 (n)
  • 95.73 (a)
TIAM1 36
  • 96 (a)
(Mus musculus)
Mammalia Tiam1 35
  • 89.38 (n)
  • 95.47 (a)
Tiam1 16
Tiam1 36
  • 95 (a)
(Monodelphis domestica)
Mammalia TIAM1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TIAM1 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Tiam1 35
  • 88.87 (n)
  • 95.16 (a)
(Gallus gallus)
Aves TIAM1 35
  • 79.32 (n)
  • 87.05 (a)
TIAM1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia TIAM1 36
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25648 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tiam1 35
  • 72.57 (n)
  • 78.79 (a)
(Danio rerio)
Actinopterygii LOC100330358 35
  • 65.03 (n)
  • 66.75 (a)
TIAM1 (1 of 3) 36
  • 64 (a)
TIAM1 (3 of 3) 36
  • 17 (a)
tiam1a 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta sif 36
  • 19 (a)
sif 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for TIAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAM1 Gene

Gene Tree for TIAM1 (if available)
Gene Tree for TIAM1 (if available)

Paralogs for TIAM1 Gene

Selected SIMAP similar genes for TIAM1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIAM1: view

Variants for TIAM1 Gene

Sequence variations from dbSNP and Humsavar for TIAM1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1831 -- 31,466,408(-) ATCCT(C/T)TATTC intron-variant
rs9358 -- 31,118,575(+) GCACC(C/T)TCTCC utr-variant-3-prime
rs13453 -- 31,118,616(+) GATGT(G/T)TTGCA utr-variant-3-prime
rs473296 -- 31,456,507(+) TTTTA(A/T)GATAA intron-variant
rs473348 -- 31,445,564(+) TGACT(A/G)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIAM1 Gene

Variant ID Type Subtype PubMed ID
esv32755 CNV Gain 17666407
esv2723329 CNV Deletion 23290073
esv2668093 CNV Deletion 23128226
nsv819990 CNV Loss 19587683
nsv828862 CNV Loss 20364138
esv2723330 CNV Deletion 23290073
nsv459238 CNV Gain 19166990
esv2659845 CNV Deletion 23128226
nsv828863 CNV Loss 20364138
nsv913678 CNV Loss 21882294
nsv525026 CNV Loss 19592680
nsv913679 CNV Gain 21882294
nsv519899 CNV Gain 19592680
esv2671245 CNV Deletion 23128226
esv2723331 CNV Deletion 23290073
esv1536810 CNV Deletion 17803354

Relevant External Links for TIAM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAM1 Gene

Disorders for TIAM1 Gene

(1) University of Copenhagen DISEASES for TIAM1 Gene

(13) Novoseek inferred disease relationships for TIAM1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 53.9 49
colorectal carcinoma 44.4 16
tumors 33.4 42
lymphoma 33.2 9
colon tumor 24.2 3

Relevant External Links for TIAM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TIAM1: view

No data available for UniProtKB/Swiss-Prot for TIAM1 Gene

Publications for TIAM1 Gene

  1. Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. (PMID: 8595894) Chen H. … Antonarakis S.E. (Genomics 1995) 2 3 23
  2. Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. (PMID: 7731688) Habets G.G.M. … Collard J.G. (Oncogene 1995) 3 4 23
  3. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. (PMID: 15899863) Connolly B.A. … Buchsbaum R.J. (Mol. Cell. Biol. 2005) 3 4 23
  4. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. (PMID: 15340013) Uhlenbrock K. … Ahmadian M.R. (J. Cell. Sci. 2004) 2 3 23
  5. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. (PMID: 20361982) Shepherd T.R. … Fuentes E.J. (J. Mol. Biol. 2010) 3 4 23

Products for TIAM1 Gene

  • Addgene plasmids for TIAM1

Sources for TIAM1 Gene

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