Aliases for TIAM1 Gene
External Ids for TIAM1 Gene
Previous GeneCards Identifiers for TIAM1 Gene
GeneCards Summary for TIAM1 Gene
TIAM1 (T-Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include Lymphoma and Colorectal Cancer. Among its related pathways are Development Slit-Robo signaling and p75 NTR receptor-mediated signalling. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TIAM2.
UniProtKB/Swiss-Prot for TIAM1 Gene
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.