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Aliases for TIAM1 Gene

Aliases for TIAM1 Gene

  • T-Cell Lymphoma Invasion And Metastasis 1 2 3 5
  • TIAM-1 3 4
  • Human T-Lymphoma Invasion And Metastasis Inducing TIAM1 Protein 3
  • T-Lymphoma Invasion And Metastasis-Inducing Protein 1 3

External Ids for TIAM1 Gene

Previous GeneCards Identifiers for TIAM1 Gene

  • GC21M029069
  • GC21M031411
  • GC21M031412
  • GC21M031414
  • GC21M032361
  • GC21M017900
  • GC21M032490

Summaries for TIAM1 Gene

Entrez Gene Summary for TIAM1 Gene

  • This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]

GeneCards Summary for TIAM1 Gene

TIAM1 (T-Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include Lymphoma and Colorectal Cancer. Among its related pathways are p75 NTR receptor-mediated signalling and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TIAM2.

UniProtKB/Swiss-Prot for TIAM1 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Gene Wiki entry for TIAM1 Gene

Additional gene information for TIAM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAM1 Gene

Genomics for TIAM1 Gene

Regulatory Elements for TIAM1 Gene

Enhancers for TIAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H031407 1.1 FANTOM5 ENCODE 16.8 +150.4 150449 3 HDGF ZSCAN5A PKNOX1 ZSCAN26 SUZ12 ZSCAN4 TSC22D4 CEBPG GLI4 ZNF48 SCAF4 MIS18A ENSG00000238390 TIAM1 URB1 MIS18A-AS1 LOC150051 LOC100129168 GC21M031330
GH21H031559 1.2 FANTOM5 ENCODE 13.3 +2.5 2529 0 PKNOX1 ZSCAN4 INSM2 KLF17 ZNF2 ZNF121 GLIS2 ZSCAN5C SCRT2 ZNF391 TIAM1 LOC150051 GC21P031506
GH21H031173 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +385.6 385579 2 L3MBTL2 MAX ZIC2 NR2F2 ZFP69B ZFHX2 ZNF692 ZNF341 ZNF600 RCOR1 ENSG00000238390 LOC102724449 SOD1 TIAM1 LOC150051 GC21P031202 GC21M031017
GH21H031180 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +377.2 377150 5 CTCF ZNF654 SMC3 ZNF384 PRDM4 ZBTB40 RAD21 LOC150051 TIAM1 GC21P031202 GC21M031017
GH21H031530 0.8 ENCODE 17.7 +29.0 28997 1 KLF1 NFIB FEZF1 ZIC2 ZNF324 ZFHX2 ZNF366 ZSCAN5C PATZ1 PRDM10 TIAM1 LOC150051 GC21P031506
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIAM1 on UCSC Golden Path with GeneCards custom track

Promoters for TIAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141322 777 1201 PKNOX1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF143 SP3 GLIS1 ZNF624

Genomic Location for TIAM1 Gene

Chromosome:
21
Start:
31,118,416 bp from pter
End:
31,559,977 bp from pter
Size:
441,562 bases
Orientation:
Minus strand

Genomic View for TIAM1 Gene

Genes around TIAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAM1 Gene

Proteins for TIAM1 Gene

  • Protein details for TIAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13009-TIAM1_HUMAN
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 1
    Protein Accession:
    Q13009
    Secondary Accessions:
    • B7ZLR6
    • F5GZ53
    • Q17RT7

    Protein attributes for TIAM1 Gene

    Size:
    1591 amino acids
    Molecular mass:
    177508 Da
    Quaternary structure:
    • Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for TIAM1 Gene

    Alternative splice isoforms for TIAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAM1 Gene

Post-translational modifications for TIAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIAM1 Gene

Domains & Families for TIAM1 Gene

Suggested Antigen Peptide Sequences for TIAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13009

UniProtKB/Swiss-Prot:

TIAM1_HUMAN :
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
  • Belongs to the TIAM family.
Domain:
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
Family:
  • Belongs to the TIAM family.
genes like me logo Genes that share domains with TIAM1: view

Function for TIAM1 Gene

Molecular function for TIAM1 Gene

GENATLAS Biochemistry:
murine T lymphoma invasion and metastasis inducing gene 1 (Tiam1) homolog,overexpressed in bone marrow of Down syndrome children during the acute phase of AML (M7),involved in neural cell development
UniProtKB/Swiss-Prot Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Phenotypes From GWAS Catalog for TIAM1 Gene

Gene Ontology (GO) - Molecular Function for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor IEA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 15324660
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with TIAM1: view
genes like me logo Genes that share phenotypes with TIAM1: view

Animal Models for TIAM1 Gene

MGI Knock Outs for TIAM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TIAM1
  • Applied Biological Materials Clones for TIAM1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAM1 Gene

Localization for TIAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM1 Gene

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIAM1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
cytoskeleton 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TIAM1: view

Pathways & Interactions for TIAM1 Gene

genes like me logo Genes that share pathways with TIAM1: view

SIGNOR curated interactions for TIAM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003300 cardiac muscle hypertrophy IEA --
GO:0006915 apoptotic process IEA --
GO:0007160 cell-matrix adhesion IMP 20361982
GO:0007165 signal transduction IEA --
GO:0008284 positive regulation of cell proliferation IDA 25032858
genes like me logo Genes that share ontologies with TIAM1: view

Drugs & Compounds for TIAM1 Gene

(3) Drugs for TIAM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(9) Additional Compounds for TIAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAM1: view

Transcripts for TIAM1 Gene

Unigene Clusters for TIAM1 Gene

T-cell lymphoma invasion and metastasis 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TIAM1
  • Applied Biological Materials Clones for TIAM1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for TIAM1 Gene

GeneLoc Exon Structure for
TIAM1
ECgene alternative splicing isoforms for
TIAM1

Expression for TIAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIAM1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.6) and Brain - Cerebellum (x10.3).

Protein differential expression in normal tissues from HIPED for TIAM1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.5) and Plasma (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIAM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TIAM1 Gene:

TIAM1

SOURCE GeneReport for Unigene cluster for TIAM1 Gene:

Hs.517228

mRNA Expression by UniProt/SwissProt for TIAM1 Gene:

Q13009-TIAM1_HUMAN
Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Evidence on tissue expression from TISSUES for TIAM1 Gene

  • Nervous system(4.8)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TIAM1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAM1 Gene

Orthologs for TIAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAM1 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia TIAM1 33 34
  • 91.31 (n)
cow
(Bos Taurus)
Mammalia TIAM1 33 34
  • 90.49 (n)
mouse
(Mus musculus)
Mammalia Tiam1 33 16 34
  • 89.38 (n)
rat
(Rattus norvegicus)
Mammalia Tiam1 33
  • 88.87 (n)
oppossum
(Monodelphis domestica)
Mammalia TIAM1 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIAM1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIAM1 33 34
  • 79.32 (n)
lizard
(Anolis carolinensis)
Reptilia TIAM1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiam1 33
  • 72.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25648 33
zebrafish
(Danio rerio)
Actinopterygii LOC100330358 33
  • 65.03 (n)
TIAM1 (1 of 3) 34
  • 64 (a)
OneToMany
tiam1a 34
  • 62 (a)
OneToMany
TIAM1 (3 of 3) 34
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sif 35 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
ManyToMany
Species where no ortholog for TIAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAM1 Gene

ENSEMBL:
Gene Tree for TIAM1 (if available)
TreeFam:
Gene Tree for TIAM1 (if available)

Paralogs for TIAM1 Gene

Paralogs for TIAM1 Gene

(2) SIMAP similar genes for TIAM1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIAM1: view

Variants for TIAM1 Gene

Sequence variations from dbSNP and Humsavar for TIAM1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_035977 A colorectal cancer sample
VAR_035978 A colorectal cancer sample
rs1000000483 -- 31,540,856(+) AGAAA(C/T)GGAGA intron-variant
rs1000010790 -- 31,274,075(+) GCCAG(A/G)CATGG intron-variant
rs1000012194 -- 31,208,585(+) AAAGC(A/C)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIAM1 Gene

Variant ID Type Subtype PubMed ID
dgv2379n106 CNV deletion 24896259
dgv811e214 CNV gain 21293372
esv1536810 CNV deletion 17803354
esv2659845 CNV deletion 23128226
esv2668093 CNV deletion 23128226
esv2671245 CNV deletion 23128226
esv2723329 CNV deletion 23290073
esv2723330 CNV deletion 23290073
esv2723331 CNV deletion 23290073
esv2762107 CNV gain 21179565
esv32755 CNV gain 17666407
esv3435719 CNV insertion 20981092
esv3575385 CNV gain 25503493
esv3646851 CNV loss 21293372
esv3646854 CNV loss 21293372
esv3646858 CNV loss 21293372
esv3646860 CNV loss 21293372
esv3646861 CNV loss 21293372
esv3646863 CNV gain 21293372
esv3646864 CNV loss 21293372
esv3646865 CNV loss 21293372
nsv1061254 CNV gain 25217958
nsv1067151 CNV gain 25217958
nsv1073124 CNV deletion 25765185
nsv1116916 CNV deletion 24896259
nsv1123551 CNV deletion 24896259
nsv1127892 CNV deletion 24896259
nsv1136622 CNV deletion 24896259
nsv1152605 CNV insertion 26484159
nsv459238 CNV gain 19166990
nsv519899 CNV gain 19592680
nsv525026 CNV loss 19592680
nsv587362 CNV gain 21841781
nsv587363 CNV gain 21841781
nsv587364 CNV gain 21841781
nsv819990 CNV loss 19587683
nsv828862 CNV loss 20364138
nsv828863 CNV loss 20364138
nsv953353 CNV deletion 24416366

Variation tolerance for TIAM1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.44; 96.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIAM1 Gene

Human Gene Mutation Database (HGMD)
TIAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAM1 Gene

Disorders for TIAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TIAM1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TIAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIAM1

Genetic Association Database (GAD)
TIAM1
Human Genome Epidemiology (HuGE) Navigator
TIAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIAM1
genes like me logo Genes that share disorders with TIAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIAM1 Gene

Publications for TIAM1 Gene

  1. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. (PMID: 20361982) Shepherd TR … Fuentes EJ (Journal of molecular biology 2010) 3 4 22 60
  2. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. (PMID: 15899863) Connolly BA … Buchsbaum RJ (Molecular and cellular biology 2005) 3 4 22 60
  3. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. (PMID: 15340013) Uhlenbrock K … Ahmadian MR (Journal of cell science 2004) 2 3 22 60
  4. Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. (PMID: 8595894) Chen H … Antonarakis SE (Genomics 1995) 2 3 22 60
  5. Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. (PMID: 7731688) Habets GG … Collard JG (Oncogene 1995) 3 4 22 60

Products for TIAM1 Gene

  • Addgene plasmids for TIAM1

Sources for TIAM1 Gene

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