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Aliases for TIAM1 Gene

Aliases for TIAM1 Gene

  • T-Cell Lymphoma Invasion And Metastasis 1 2 3 5
  • TIAM-1 3 4
  • Human T-Lymphoma Invasion And Metastasis Inducing TIAM1 Protein 3
  • T-Lymphoma Invasion And Metastasis-Inducing Protein 1 3

External Ids for TIAM1 Gene

Previous GeneCards Identifiers for TIAM1 Gene

  • GC21M029069
  • GC21M031411
  • GC21M031412
  • GC21M031414
  • GC21M032361
  • GC21M017900
  • GC21M032490

Summaries for TIAM1 Gene

GeneCards Summary for TIAM1 Gene

TIAM1 (T-Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include Lymphoma and Colorectal Cancer. Among its related pathways are Signaling by GPCR and Cytoskeleton remodeling_Role of PDGFs in cell migration. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TIAM2.

UniProtKB/Swiss-Prot for TIAM1 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Gene Wiki entry for TIAM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAM1 Gene

Genomics for TIAM1 Gene

Regulatory Elements for TIAM1 Gene

Enhancers for TIAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F031443 1.2 Ensembl ENCODE 18.7 +114.1 114140 5.5 BCOR PKNOX1 NR2F1 BHLHE40 ZMYM3 EBF1 TEAD3 OSR2 BCL11A NR2F6 TIAM1 LOC150051 LOC100129168 GC21M031330
GH21F031529 0.5 ENCODE 18.1 +30.1 30115 0.7 RFX1 SIN3A ZNF217 MBD2 OSR2 CTBP1 JUND GATA3 GLIS1 TIAM1 LOC150051 GC21P031506
GH21F031530 0.5 ENCODE 17.7 +29.0 28997 1.0 KLF1 FEZF1 ZIC2 ZNF101 ZNF324 ZFHX2 ZNF366 PATZ1 PRDM10 KLF7 TIAM1 LOC150051 GC21P031506
GH21F031407 1.1 FANTOM5 Ensembl ENCODE 16.8 +150.4 150449 3.5 CTCF HDGF ZSCAN5A TBP PKNOX1 SUZ12 TSC22D4 GLI4 ZNF48 ZNF121 TIAM1 LOC150051 LOC100129168 GC21M031330
GH21F031413 0.5 ENCODE 16.6 +145.3 145304 1.8 ZNF664 ZNF316 JUND HLF TIAM1 LOC150051 LOC100129168 GC21M031330
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TIAM1 on UCSC Golden Path with GeneCards custom track

Promoters for TIAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000684125 977 2401 HDGF PKNOX1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF143 SP3 JUNB

Genomic Location for TIAM1 Gene

Chromosome:
21
Start:
31,118,416 bp from pter
End:
31,559,977 bp from pter
Size:
441,562 bases
Orientation:
Minus strand

Genomic View for TIAM1 Gene

Genes around TIAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAM1 Gene

Proteins for TIAM1 Gene

  • Protein details for TIAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13009-TIAM1_HUMAN
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 1
    Protein Accession:
    Q13009
    Secondary Accessions:
    • B7ZLR6
    • F5GZ53
    • Q17RT7

    Protein attributes for TIAM1 Gene

    Size:
    1591 amino acids
    Molecular mass:
    177508 Da
    Quaternary structure:
    • Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for TIAM1 Gene

    Alternative splice isoforms for TIAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAM1 Gene

Post-translational modifications for TIAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for TIAM1

No data available for DME Specific Peptides for TIAM1 Gene

Domains & Families for TIAM1 Gene

Suggested Antigen Peptide Sequences for TIAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13009

UniProtKB/Swiss-Prot:

TIAM1_HUMAN :
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
  • Belongs to the TIAM family.
Domain:
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 2 PH domains.
  • Contains 1 RBD (Ras-binding) domain.
Family:
  • Belongs to the TIAM family.
genes like me logo Genes that share domains with TIAM1: view

Function for TIAM1 Gene

Molecular function for TIAM1 Gene

GENATLAS Biochemistry:
murine T lymphoma invasion and metastasis inducing gene 1 (Tiam1) homolog,overexpressed in bone marrow of Down syndrome children during the acute phase of AML (M7),involved in neural cell development
UniProtKB/Swiss-Prot Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Gene Ontology (GO) - Molecular Function for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor IEA --
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 23109420
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with TIAM1: view
genes like me logo Genes that share phenotypes with TIAM1: view

Animal Models for TIAM1 Gene

MGI Knock Outs for TIAM1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAM1 Gene

Localization for TIAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM1 Gene

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIAM1 Gene COMPARTMENTS Subcellular localization image for TIAM1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 4
cytoskeleton 3
endosome 1

Gene Ontology (GO) - Cellular Components for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TIAM1: view

Pathways & Interactions for TIAM1 Gene

genes like me logo Genes that share pathways with TIAM1: view

SIGNOR curated interactions for TIAM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003300 cardiac muscle hypertrophy IEA --
GO:0006915 apoptotic process IEA --
GO:0007160 cell-matrix adhesion IMP 20361982
GO:0007165 signal transduction IEA --
GO:0008284 positive regulation of cell proliferation IDA 25032858
genes like me logo Genes that share ontologies with TIAM1: view

Drugs & Compounds for TIAM1 Gene

(3) Drugs for TIAM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(9) Additional Compounds for TIAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAM1: view

Transcripts for TIAM1 Gene

Unigene Clusters for TIAM1 Gene

T-cell lymphoma invasion and metastasis 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for TIAM1 Gene

GeneLoc Exon Structure for
TIAM1
ECgene alternative splicing isoforms for
TIAM1

Expression for TIAM1 Gene

mRNA expression in normal human tissues for TIAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIAM1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.6) and Brain - Cerebellum (x10.3).

Protein differential expression in normal tissues from HIPED for TIAM1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.5) and Plasma (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIAM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TIAM1 Gene:

TIAM1

SOURCE GeneReport for Unigene cluster for TIAM1 Gene:

Hs.517228

mRNA Expression by UniProt/SwissProt for TIAM1 Gene:

Q13009-TIAM1_HUMAN
Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
genes like me logo Genes that share expression patterns with TIAM1: view

Primer Products

No data available for Protein tissue co-expression partners for TIAM1 Gene

Orthologs for TIAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAM1 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia TIAM1 34 35
  • 91.31 (n)
cow
(Bos Taurus)
Mammalia TIAM1 34 35
  • 90.49 (n)
mouse
(Mus musculus)
Mammalia Tiam1 34 16 35
  • 89.38 (n)
rat
(Rattus norvegicus)
Mammalia Tiam1 34
  • 88.87 (n)
oppossum
(Monodelphis domestica)
Mammalia TIAM1 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIAM1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIAM1 34 35
  • 79.32 (n)
lizard
(Anolis carolinensis)
Reptilia TIAM1 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiam1 34
  • 72.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25648 34
zebrafish
(Danio rerio)
Actinopterygii LOC100330358 34
  • 65.03 (n)
TIAM1 (1 of 3) 35
  • 64 (a)
OneToMany
tiam1a 35
  • 62 (a)
OneToMany
TIAM1 (3 of 3) 35
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sif 36 35
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
ManyToMany
Species where no ortholog for TIAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAM1 Gene

ENSEMBL:
Gene Tree for TIAM1 (if available)
TreeFam:
Gene Tree for TIAM1 (if available)

Paralogs for TIAM1 Gene

(2) SIMAP similar genes for TIAM1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIAM1: view

Variants for TIAM1 Gene

Sequence variations from dbSNP and Humsavar for TIAM1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_035977 A colorectal cancer sample
VAR_035978 A colorectal cancer sample
rs1016709 -- 31,330,759(+) AAATG(A/C)AAAGA intron-variant
rs10211860 -- 31,226,977(+) tttga(A/C/G)acagg intron-variant
rs10211886 -- 31,503,796(+) AAAGA(A/C)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TIAM1 Gene

Variant ID Type Subtype PubMed ID
dgv2379n106 CNV deletion 24896259
dgv811e214 CNV gain 21293372
esv1536810 CNV deletion 17803354
esv2659845 CNV deletion 23128226
esv2668093 CNV deletion 23128226
esv2671245 CNV deletion 23128226
esv2723329 CNV deletion 23290073
esv2723330 CNV deletion 23290073
esv2723331 CNV deletion 23290073
esv2762107 CNV gain 21179565
esv32755 CNV gain 17666407
esv3435719 CNV insertion 20981092
esv3575385 CNV gain 25503493
esv3646851 CNV loss 21293372
esv3646854 CNV loss 21293372
esv3646858 CNV loss 21293372
esv3646860 CNV loss 21293372
esv3646861 CNV loss 21293372
esv3646863 CNV gain 21293372
esv3646864 CNV loss 21293372
esv3646865 CNV loss 21293372
nsv1061254 CNV gain 25217958
nsv1067151 CNV gain 25217958
nsv1073124 CNV deletion 25765185
nsv1116916 CNV deletion 24896259
nsv1123551 CNV deletion 24896259
nsv1127892 CNV deletion 24896259
nsv1136622 CNV deletion 24896259
nsv1152605 CNV insertion 26484159
nsv459238 CNV gain 19166990
nsv519899 CNV gain 19592680
nsv525026 CNV loss 19592680
nsv587362 CNV gain 21841781
nsv587363 CNV gain 21841781
nsv587364 CNV gain 21841781
nsv819990 CNV loss 19587683
nsv828862 CNV loss 20364138
nsv828863 CNV loss 20364138
nsv953353 CNV deletion 24416366

Variation tolerance for TIAM1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.44; 96.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAM1 Gene

Disorders for TIAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TIAM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TIAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIAM1

Genetic Association Database (GAD)
TIAM1
Human Genome Epidemiology (HuGE) Navigator
TIAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIAM1
genes like me logo Genes that share disorders with TIAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIAM1 Gene

Publications for TIAM1 Gene

  1. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. (PMID: 20361982) Shepherd T.R. … Fuentes E.J. (J. Mol. Biol. 2010) 3 4 22 64
  2. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. (PMID: 15899863) Connolly B.A. … Buchsbaum R.J. (Mol. Cell. Biol. 2005) 3 4 22 64
  3. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. (PMID: 15340013) Uhlenbrock K. … Ahmadian M.R. (J. Cell. Sci. 2004) 2 3 22 64
  4. Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. (PMID: 8595894) Chen H. … Antonarakis S.E. (Genomics 1995) 2 3 22 64
  5. Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. (PMID: 7731688) Habets G.G.M. … Collard J.G. (Oncogene 1995) 3 4 22 64

Products for TIAM1 Gene

Sources for TIAM1 Gene

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