Aliases for TIAM1 Gene
External Ids for TIAM1 Gene
Previous GeneCards Identifiers for TIAM1 Gene
GeneCards Summary for TIAM1 Gene
TIAM1 (T-Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include lymphoma and colorectal cancer. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for TIAM1 Gene
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.