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TIAM1 Gene

protein-coding   GIFtS: 69
GCID: GC21M032490

T-Cell Lymphoma Invasion And Metastasis 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
T-Cell Lymphoma Invasion And Metastasis 11 2
Human T-Lymphoma Invasion And Metastasis Inducing TIAM1 Protein2 11
TIAM-12 3
T-Lymphoma Invasion And Metastasis-Inducing Protein 12

External Ids:    HGNC: 118051   Entrez Gene: 70742   Ensembl: ENSG000001562997   OMIM: 6006875   UniProtKB: Q130093   

Export aliases for TIAM1 gene to outside databases

Previous GC identifers: GC21M029069 GC21M031411 GC21M031412 GC21M031414 GC21M032361 GC21M017900


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TIAM1 Gene:
TIAM1 (T-cell lymphoma invasion and metastasis 1) is a protein-coding gene. Diseases associated with TIAM1 include spastic quadriplegia, and quadriplegia. GO annotations related to this gene include phospholipid binding and receptor signaling protein activity. An important paralog of this gene is ARHGEF6.

UniProtKB/Swiss-Prot: TIAM1_HUMAN, Q13009
Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal
activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of
RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell
adhesion and cell migration

Gene Wiki entry for TIAM1 (T-cell lymphoma invasion and metastasis-inducing protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIAM1 gene promoter:
         SRF   GATA-3   AP-1   SRF (504 AA)   ATF-2   GATA-1   HOXA5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTIAM1 promoter sequence

   Search Chromatin IP Primers for TIAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
TIAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIAM1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M032490:   GeneLoc Nature:405,311-319
Start:
32,490,734 bp from pter       18,069,188 bp from centromere
End:
32,932,290 bp from pter 18,507,997 bp from centromere
Size:
441,557 bases 438,810 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: U16296
genomic clones: R137B7 to pS158


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TIAM1_HUMAN, Q13009 (See protein sequence)
Recommended Name: T-lymphoma invasion and metastasis-inducing protein 1  
Size: 1591 amino acids; 177508 Da
Subunit: Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1.
Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity).
Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with
PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus)
Selected PDB 3D structures from and Proteopedia for TIAM1 (see all 7):
2D8I (3D)        3KZD (3D)        3KZE (3D)        4GVC (3D)        4GVD (3D)        4K2O (3D)    
Secondary accessions: Q17RT7

Explore the universe of human proteins at neXtProt for TIAM1: NX_Q13009

Explore proteomics data for TIAM1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TIAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003244.2  
    ENSEMBL proteins: 
     ENSP00000286827   ENSP00000393384   ENSP00000388217   ENSP00000441570  
    Reactome Protein details: Q13009

    TIAM1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TIAM1
    OriGene Protein Over-expression Lysate for TIAM1
    OriGene MassSpec for TIAM1
    OriGene Custom Protein Services for TIAM1
    GenScript Custom Purified and Recombinant Proteins Services for TIAM1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TIAM1

    TIAM1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TIAM1 Antibodies
    Abcam antibodies for TIAM1
    Cloud-Clone Corp. Antibodies for TIAM1
    ThermoFisher Antibodies for TIAM1
    LSBio Antibodies in human, mouse, rat for TIAM1

    TIAM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIAM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIAM1
    Cloud-Clone Corp. CLIAs for TIAM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 6):
     IPR001331 GDS_CDC24_CS
     IPR001478 PDZ
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR003116 Raf-like_ras-bd

    Graphical View of Domain Structure for InterPro Entry Q13009

    ProtoNet protein and cluster: Q13009

    4 Blocks protein domains:
    IPB000219 DH domain
    IPB001478 PDZ/DHR/GLGF domain
    IPB001849 Pleckstrin-like
    IPB003116 Raf-like Ras-binding


    UniProtKB/Swiss-Prot: TIAM1_HUMAN, Q13009
    Domain: The first PH domain mediates interaction with membranes enriched in phosphoinositides (By similarity)
    Similarity: Belongs to the TIAM family
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 2 PH domains
    Similarity: Contains 1 RBD (Ras-binding) domain


    TIAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIAM1_HUMAN, Q13009
    Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal
    activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of
    RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell
    adhesion and cell migration

         Genatlas biochemistry entry for TIAM1:
    murine T lymphoma invasion and metastasis inducing gene 1 (Tiam1) homolog,overexpressed in bone marrow of Down
    syndrome children during the acute phase of AML (M7),involved in neural cell development

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity TAS10835422
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    TIAM1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tiam1):
     cellular  homeostasis/metabolism  nervous system  tumorigenesis 

    TIAM1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIAM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIAM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIAM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIAM1:
    hsa-mir-769-3p (MIRT039107), hsa-mir-615-3p (MIRT040238), hsa-let-7b-5p (MIRT052155), hsa-mir-93-3p (MIRT038766), hsa-mir-21-5p (MIRT005565), hsa-mir-335-5p (MIRT018498), hsa-mir-31-5p (MIRT005566), hsa-mir-221-3p (MIRT046873), hsa-mir-744-5p (MIRT037502)

    Block miRNA regulation of human, mouse, rat TIAM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIAM1 (see all 59):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-3607-3p hsa-miR-376b hsa-miR-548k hsa-miR-106a hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmidTIAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIAM1
    Predesigned siRNA for gene silencing in human, mouse, rat TIAM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIAM1

    Clone
    Products:
         
    OriGene clones in human, mouse for TIAM1 (see all 9)
    OriGene ORF clones in mouse, rat for TIAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIAM1 (NM_003253)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAM1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TIAM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TIAM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIAM1_HUMAN, Q13009: Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected
    at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is
    required for its localization to the cell junction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----
    GO:0005911cell-cell junction IDA--
    GO:0031234extrinsic component of cytoplasmic side of plasma membrane IDA--
    GO:0044291cell-cell contact zone IDA--

    TIAM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TIAM1 About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    5Signaling by FGFR
    Signalling by NGF0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TIAM1
        Rac1 Pathway
    Epithelial Tight Junctions
    PDGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for TIAM1 (see all 9)
        G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Regulation of RAC1 activity
    G-protein signaling H-RAS regulation pathway
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Role of PDGFs in cell migration

    Selected BioSystems Pathways for TIAM1 (see all 11)
        BDNF signaling pathway
    LPA receptor mediated events
    EPHA2 forward signaling
    Neurotrophic factor-mediated Trk receptor signaling
    CDC42 signaling events

    3 Reactome Pathways for TIAM1
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle


    5 Kegg Pathways  (Kegg details for TIAM1):
        Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Regulation of actin cytoskeleton
    Proteoglycans in cancer


    TIAM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TIAM1: 
              Cytoskeleton Regulators in human mouse rat
              Tight Junctions in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TIAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIAM1 (Q130092, 3 ENSP000002868274) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50808 I2D: score=4 STRING: ENSP00000306330
    PARD3Q8TEW02, 3, ENSP000003639214MINT-3380813 I2D: score=3 STRING: ENSP00000363921
    HRASP011123, ENSP000003098454I2D: score=4 STRING: ENSP00000309845
    ANK1P161573, ENSP000002657094I2D: score=3 STRING: ENSP00000265709
    MAPK8IP1Q9UQF23, ENSP000002410144I2D: score=3 STRING: ENSP00000241014
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion IMP--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0016477cell migration IMP--
    GO:0016601Rac protein signal transduction IMP--

    TIAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIAM1

    1 HMDB Compound for TIAM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for TIAM1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 68.6 11 10893266 (3), 8570171 (1), 15242348 (1), 18505730 (1) (see all 6)
    bufalin 68.2 10 17352239 (5), 10229192 (4)
    gtp 54.7 14 10893266 (3), 15242348 (1), 18505730 (1), 14641027 (1) (see all 5)
    phosphatidylinositol 3-phosphate 53.4 3 12525493 (2), 11577097 (1)
    phosphoinositide 46.2 9 17339315 (2), 10734127 (1), 12525493 (1), 11577097 (1)
    matrigel 37.1 1 19575901 (1)
    guanine 30.6 2 19082465 (1), 20361982 (1)
    tyrosine 13.9 6 12810717 (2), 9407095 (1), 20333299 (1), 17440041 (1)
    phosphatidylinositol 9.87 5 16267014 (1), 14663478 (1), 9268346 (1)
    lipid 0 2 10998360 (1), 11577097 (1)



    TIAM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TIAM1 gene: 
    NM_003253.2  

    Unigene Cluster for TIAM1:

    T-cell lymphoma invasion and metastasis 1
    Hs.517228  [show with all ESTs]
    Unigene Representative Sequence: NM_003253
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286827(uc011adk.1 uc011adl.1 uc002yow.1) ENST00000423206
    ENST00000491927 ENST00000469412(uc002yox.1) ENST00000455508 ENST00000541036

    miRNA
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    Block miRNA regulation of human, mouse, rat TIAM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIAM1 (see all 59):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-3607-3p hsa-miR-376b hsa-miR-548k hsa-miR-106a hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmidTIAM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TIAM1
    Predesigned siRNA for gene silencing in human, mouse, rat TIAM1
    Clone
    Products:
         
    OriGene clones in human, mouse for TIAM1 (see all 9)
    OriGene ORF clones in mouse, rat for TIAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TIAM1 (NM_003253)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAM1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TIAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIAM1
      QuantiTect SYBR Green Assays in human, mouse, rat TIAM1
      QuantiFast Probe-based Assays in human, mouse, rat TIAM1

    Additional mRNA sequence: 

    AB209101.1 AK093621.1 AK124647.1 BC117192.1 BC117196.1 BC143970.1 BC143980.1 U16296.1 
    U90902.1 

    11 DOTS entries:

    DT.95365610  DT.100710340  DT.121138661  DT.86854229  DT.97797101  DT.455337  DT.121138692  DT.100741632 
    DT.100868348  DT.102830912  DT.91703834 

    Selected AceView cDNA sequences (see all 163):

    X86351 BQ004667 R25910 BM556620 AI079343 AI338955 F03475 N50956 
    AI497820 F04327 AI382503 AI433796 AA947650 AI918151 R39451 F03222 
    BF195102 F13242 X86350 N23108 AI242287 CA942824 CD367453 CR597039 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TIAM1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                    -     -           -                                               -                 -                                                   
    SP2:        -           -     -           -     -     -                                   -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TIAM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIAM1 expression in normal human tissues (normalized intensities)      TIAM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGTGTCTAT
    TIAM1 Expression
    About this image


    TIAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Brain (Nervous System)
             Cerebellum
    TIAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517228

    UniProtKB/Swiss-Prot: TIAM1_HUMAN, Q13009
    Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas,
    melanomas and carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TIAM1: 
              Cytoskeleton Regulators in human mouse rat
              Tight Junctions in human mouse rat
              Cardiotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TIAM1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tiam11 , 5 T cell lymphoma invasion and metastasis 11, 5 89.38(n)1
    95.47(a)1
      16 (51.50 cM)5
    218441  NM_009384.31  NP_033410.21 
     897871115 
    chicken
    (Gallus gallus)
    Aves TIAM11 T-cell lymphoma invasion and metastasis 1 79.32(n)
    87.05(a)
      418491  XM_416699.4  XP_416699.2 
    lizard
    (Anolis carolinensis)
    Reptilia TIAM16
    T-cell lymphoma invasion and metastasis 1
    84(a)
    1 ↔ 1
    3(145880089-145992949)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256482 Xenopus laevis transcribed sequence with moderate similarity more 75.48(n)    BX852344.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003303581 t-lymphoma invasion and metastasis-inducing protein more 65.03(n)
    66.75(a)
      100330358  XM_002664702.3  XP_002664748.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta sif3 actin cytoskeleton organization and
    biogenesis more
    35(a)     --


    ENSEMBL Gene Tree for TIAM1 (if available)
    TreeFam Gene Tree for TIAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TIAM1 gene
    ARHGEF62  PLEKHG22  PLEKHG32  PREX22  ENSG000002731672  ARHGEF72  SPATA132  TIAM22  
    ARHGEF92  ARHGEF42  PLEKHG12  PREX12  
    2 SIMAP similar genes for TIAM1 using alignment to 5 protein entries:     TIAM1_HUMAN (see all proteins):
    TIAM2    PREX2

    TIAM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TIAM1 (see all 10054)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359774
    A colorectal cancer sample4--see VAR_0359772 R C mis40--------
    VAR_0359784
    A colorectal cancer sample4--see VAR_0359782 A V mis40--------
    rs340609791,2
    C--18041041(+) GTCTC-/A/AA  
            
    AAAAA
    1 -- int12NA 4
    rs106344871,2
    C--18144660(+) TGACA-/ATT/
    TTATTATT
    attat
    2 -- cds10--------
    rs717915151,2
    C--18144660(+) TGACAATT/-ATTAT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs105753491,2
    C--18252461(+) CAAAC-/AAAAAAA 1 -- int11Minor allele frequency- AA:0.00CSA 2
    rs354010901,2
    C--23143198(+) TTTTT-/TTGAGAC 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs106039251,2
    C--23361621(+) AGAAA-/CAGTCTA 1 -- int10--------
    rs28332761,2
    C,F,O,A,H--32490292(+) GGACTT/CGAGAG 1 -- int119Minor allele frequency- C:0.33NA NS EA WA CSA 958
    rs1928121351,2
    --32490295(+) CTCGAA/GAGGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TIAM1 (32490734 - 32740734 bp, first 250kb of TIAM1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TIAM1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659845CNV Deletion23128226
    esv2723329CNV Deletion23290073
    esv2671245CNV Deletion23128226
    esv2723330CNV Deletion23290073
    esv2668093CNV Deletion23128226
    esv1536810CNV Deletion17803354
    esv2723331CNV Deletion23290073
    nsv525026CNV Loss19592680
    nsv819990CNV Loss19587683
    nsv828863CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600687    OMIM disorders: --

    Selected diseases for TIAM1 (see all 38):    About MalaCards
    spastic quadriplegia    quadriplegia    wolf-hirschhorn syndrome    adult t-cell leukemia
    spasticity    chondrosarcoma    conjunctivitis    fibrosarcoma
    sinusitis    retinoblastoma    intellectual disability    t-cell leukemia
    lateral sclerosis    amyotrophic lateral sclerosis    nasopharyngitis    down syndrome
    colorectal cancer    esophageal squamous cell carcinoma    osteosarcoma    cystic fibrosis

    1 disease from the University of Copenhagen DISEASES database for TIAM1:
    Lymphoma

    TIAM1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TIAM1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 53.9 83 15295645 (4), 17132223 (3), 19923095 (3), 19218104 (3) (see all 33)
    colorectal carcinoma 44.4 22 15655826 (6), 16536281 (5), 19246286 (3), 19276682 (2)
    tumors 33.4 61 17027002 (6), 16249175 (4), 10636882 (4), 19082465 (4) (see all 24)
    lymphoma 33.2 11 17376711 (1), 12974090 (1), 16801538 (1), 17132223 (1) (see all 9)
    colon tumor 24.2 4 17086355 (3)
    retinoblastoma 19.8 3 17027002 (3)
    colorectal cancer 18.2 20 17132223 (5), 17376711 (3), 17822624 (3), 16249175 (1) (see all 5)
    prostate cancer 6.96 1 17003780 (1)
    leukemia 0 3 17352239 (2), 10229192 (1)
    breast cancer 0 5 11328805 (3), 14999151 (1), 10636882 (1)

    Genetic Association Database (GAD): TIAM1
    Human Genome Epidemiology (HuGE) Navigator: TIAM1 (3 documents)

    Export disorders for TIAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TIAM1 gene, integrated from 10 sources (see all 177):
    (articles sorted by number of sources associating them with TIAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. (PubMed id 15899863)1, 2, 9 Connolly B.A.... Buchsbaum R.J. (Mol. Cell. Biol. 2005)
    2. Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. (PubMed id 8595894)1, 3, 9 Chen H. and Antonarakis S.E. (Genomics 1995)
    3. Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. (PubMed id 7731688)1, 2, 9 Habets G.G.M....Collard J.G. (Oncogene 1995)
    4. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. (PubMed id 20361982)1, 2, 9 Shepherd T.R....Fuentes E.J. (J. Mol. Biol. 2010)
    5. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. (PubMed id 15340013)1, 3, 9 Uhlenbrock K....Ahmadian M.R. (J. Cell. Sci. 2004)
    6. Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study. (PubMed id 22044751)1, 4 Foster M.C....Fox C.S. (BMC Med. Genet. 2011)
    7. EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor. (PubMed id 20496116)1, 2 Yoo S.... Park S. (Mol. Cells 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. (PubMed id 20801718)1, 4 Laaksovirta H....Traynor B.J. (Lancet Neurol 2010)
    10. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7074 HGNC: 11805 AceView: TIAM1 Ensembl:ENSG00000156299 euGenes: HUgn7074
    ECgene: TIAM1 Kegg: 7074 H-InvDB: TIAM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TIAM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TIAM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TIAM1 gene:
    Search GeneIP for patents involving TIAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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