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Aliases for TIAM1 Gene

Aliases for TIAM1 Gene

  • T-Cell Lymphoma Invasion And Metastasis 1 2 3 5
  • TIAM-1 3 4
  • Human T-Lymphoma Invasion And Metastasis Inducing TIAM1 Protein 3

External Ids for TIAM1 Gene

Previous GeneCards Identifiers for TIAM1 Gene

  • GC21M029069
  • GC21M031411
  • GC21M031412
  • GC21M031414
  • GC21M032361
  • GC21M017900
  • GC21M032490

Summaries for TIAM1 Gene

GeneCards Summary for TIAM1 Gene

TIAM1 (T-Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include Lymphoma and Colorectal Cancer. Among its related pathways are Arf6 downstream pathway and cAMP signaling pathway. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for TIAM1 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Gene Wiki entry for TIAM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAM1 Gene

Genomics for TIAM1 Gene

Regulatory Elements for TIAM1 Gene

Enhancers for TIAM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TIAM1 on UCSC Golden Path with GeneCards custom track

Promoters for TIAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TIAM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIAM1 Gene

Chromosome:
21
Start:
31,118,416 bp from pter
End:
31,559,977 bp from pter
Size:
441,562 bases
Orientation:
Minus strand

Genomic View for TIAM1 Gene

Genes around TIAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAM1 Gene

Proteins for TIAM1 Gene

  • Protein details for TIAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13009-TIAM1_HUMAN
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 1
    Protein Accession:
    Q13009
    Secondary Accessions:
    • B7ZLR6
    • F5GZ53
    • Q17RT7

    Protein attributes for TIAM1 Gene

    Size:
    1591 amino acids
    Molecular mass:
    177508 Da
    Quaternary structure:
    • Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for TIAM1 Gene

    Alternative splice isoforms for TIAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAM1 Gene

Proteomics data for TIAM1 Gene at MOPED

Post-translational modifications for TIAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIAM1 Gene

No data available for DME Specific Peptides for TIAM1 Gene

Domains & Families for TIAM1 Gene

Suggested Antigen Peptide Sequences for TIAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13009

UniProtKB/Swiss-Prot:

TIAM1_HUMAN :
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
  • Belongs to the TIAM family.
Domain:
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 2 PH domains.
  • Contains 1 RBD (Ras-binding) domain.
Family:
  • Belongs to the TIAM family.
genes like me logo Genes that share domains with TIAM1: view

Function for TIAM1 Gene

Molecular function for TIAM1 Gene

GENATLAS Biochemistry:
murine T lymphoma invasion and metastasis inducing gene 1 (Tiam1) homolog,overexpressed in bone marrow of Down syndrome children during the acute phase of AML (M7),involved in neural cell development
UniProtKB/Swiss-Prot Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
genes like me logo Genes that share phenotypes with TIAM1: view

Animal Models for TIAM1 Gene

MGI Knock Outs for TIAM1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAM1 Gene

Localization for TIAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM1 Gene

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIAM1 Gene COMPARTMENTS Subcellular localization image for TIAM1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 4
cytoskeleton 3
endosome 1

Gene Ontology (GO) - Cellular Components for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA 23109420
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA 20361982
GO:0036477 somatodendritic compartment IEA --
genes like me logo Genes that share ontologies with TIAM1: view

Pathways & Interactions for TIAM1 Gene

genes like me logo Genes that share pathways with TIAM1: view

SIGNOR curated interactions for TIAM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007160 cell-matrix adhesion IMP 20361982
GO:0007411 axon guidance TAS --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0016601 Rac protein signal transduction IMP 20361982
genes like me logo Genes that share ontologies with TIAM1: view

Drugs & Compounds for TIAM1 Gene

(3) Drugs for TIAM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(9) Additional Compounds for TIAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAM1: view

Transcripts for TIAM1 Gene

Unigene Clusters for TIAM1 Gene

T-cell lymphoma invasion and metastasis 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for TIAM1 Gene

GeneLoc Exon Structure for
TIAM1
ECgene alternative splicing isoforms for
TIAM1

Expression for TIAM1 Gene

mRNA expression in normal human tissues for TIAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIAM1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.6) and Brain - Cerebellum (x10.3).

Protein differential expression in normal tissues from HIPED for TIAM1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.5) and Plasma (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIAM1 Gene



SOURCE GeneReport for Unigene cluster for TIAM1 Gene Hs.517228

mRNA Expression by UniProt/SwissProt for TIAM1 Gene

Q13009-TIAM1_HUMAN
Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
genes like me logo Genes that share expression patterns with TIAM1: view

Primer Products

No data available for Protein tissue co-expression partners for TIAM1 Gene

Orthologs for TIAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TIAM1 35
  • 90.49 (n)
  • 95.06 (a)
TIAM1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIAM1 35
  • 91.31 (n)
  • 95.73 (a)
TIAM1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tiam1 35
  • 89.38 (n)
  • 95.47 (a)
Tiam1 16
Tiam1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TIAM1 35
  • 99.69 (n)
  • 99.81 (a)
TIAM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tiam1 35
  • 88.87 (n)
  • 95.16 (a)
oppossum
(Monodelphis domestica)
Mammalia TIAM1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIAM1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIAM1 35
  • 79.32 (n)
  • 87.05 (a)
TIAM1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIAM1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiam1 35
  • 72.57 (n)
  • 78.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25648 35
zebrafish
(Danio rerio)
Actinopterygii LOC100330358 35
  • 65.03 (n)
  • 66.75 (a)
TIAM1 (1 of 3) 36
  • 64 (a)
OneToMany
TIAM1 (3 of 3) 36
  • 17 (a)
OneToMany
tiam1a 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sif 37
  • 35 (a)
sif 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
Species with no ortholog for TIAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAM1 Gene

ENSEMBL:
Gene Tree for TIAM1 (if available)
TreeFam:
Gene Tree for TIAM1 (if available)

Paralogs for TIAM1 Gene

(2) SIMAP similar genes for TIAM1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIAM1: view

Variants for TIAM1 Gene

Sequence variations from dbSNP and Humsavar for TIAM1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_035977 A colorectal cancer sample
VAR_035978 A colorectal cancer sample
rs2070418 - 31,266,234(+) CCCCC(A/C/T)GTTTG reference, missense
rs2070417 - 31,266,233(+) GCCCC(A/C)CGTTT reference, missense
rs16987932 - 31,195,267(+) ATGCT(C/G)TGAGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TIAM1 Gene

Variant ID Type Subtype PubMed ID
esv32755 CNV Gain 17666407
esv2723329 CNV Deletion 23290073
esv2668093 CNV Deletion 23128226
nsv819990 CNV Loss 19587683
nsv828862 CNV Loss 20364138
esv2723330 CNV Deletion 23290073
nsv459238 CNV Gain 19166990
esv2659845 CNV Deletion 23128226
nsv828863 CNV Loss 20364138
nsv913678 CNV Loss 21882294
nsv525026 CNV Loss 19592680
nsv913679 CNV Gain 21882294
nsv519899 CNV Gain 19592680
esv2671245 CNV Deletion 23128226
esv2723331 CNV Deletion 23290073
esv1536810 CNV Deletion 17803354

Variation tolerance for TIAM1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.44; 96.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TIAM1 Gene

Disorders for TIAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TIAM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TIAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TIAM1

Genetic Association Database (GAD)
TIAM1
Human Genome Epidemiology (HuGE) Navigator
TIAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIAM1
genes like me logo Genes that share disorders with TIAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIAM1 Gene

Publications for TIAM1 Gene

  1. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. (PMID: 15899863) Connolly B.A. … Buchsbaum R.J. (Mol. Cell. Biol. 2005) 3 4 23 67
  2. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. (PMID: 15340013) Uhlenbrock K. … Ahmadian M.R. (J. Cell. Sci. 2004) 2 3 23
  3. Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. (PMID: 8595894) Chen H. … Antonarakis S.E. (Genomics 1995) 2 3 23
  4. CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. (PMID: 20215110) Masuda M. … Murakami Y. (J. Biol. Chem. 2010) 3 23
  5. Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). (PMID: 20360004) Rajagopal S. … Buchsbaum R.J. (J. Biol. Chem. 2010) 3 23

Products for TIAM1 Gene

Sources for TIAM1 Gene

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